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Neutrophil Depleting Material And Method For Producing Neutrophil Depleting Material

Abstract: The purpose of the present invention is to provide a neutrophil depleting material that inhibits platelet depletion. Provided is a neutrophil depleting material that is a knitted fabric or a woven fabric containing fibers having a fiber diameter of 10-60 µm, the thickness of the knitted fabric or the woven fabric being 0.10-0.400 mm and the porosity being 10-30%.

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Patent Information

Application #
Filing Date
23 July 2024
Publication Number
31/2024
Publication Type
INA
Invention Field
BIO-MEDICAL ENGINEERING
Status
Email
Parent Application

Applicants

TORAY INDUSTRIES, INC.
1-1, Nihonbashi-Muromachi 2-chome, Chuo-ku, Tokyo 1038666

Inventors

1. KUGA Chisa
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 5208558
2. NAKANISHI Megumi
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 5208558
3. TAKAHASHI Hiroshi
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 5208558

Specification

WE CLAIM:
1. A material for removing neutrophils, the material being a knitted fabric or a woven fabric comprising a fiber having a fiber diameter of 10 to 60 pm, wherein the knitted fabric or the woven fabric has a thickness of 0.10 to 0.40 mm and a porosity of 10 to 30%.
2. The material for removing neutrophils, according to claim 1, wherein the knitted fabric or the woven fabric has a bulk density of 0.26 to 0.40 g/cm3.
3. The material for removing neutrophils, according to claim 1 or 2, wherein the knitted fabric or the woven fabric has an amino group content of 0.3 to 1.2 mmol per 1.0 g of dry mass.
4. The material for removing neutrophils, according to claim 1 or 2, wherein the knitted fabric or the woven fabric has an amide group content of 2.0 to 4.0 mmol per 1.0 g of dry mass.
5. The material for removing neutrophils, according to claim 1 or 2, wherein the knitted fabric or the woven fabric contains the fiber as a bundle of 30 to 45 filaments.
6. The material for removing neutrophils, according to claim 1 or 2, wherein the fiber is a sea-island type composite fiber.
7. The material for removing neutrophils, according to claim 6, wherein the sea-island type composite fiber contains polystyrene or a polystyrene derivative as a
sea component, and polypropylene as an island component.
8. A column for removing neutrophils comprising the material for removing neutrophils, according to claim 1 or 2. the material being packed at 0.1 to 0.4 g/cmJ.
9. A method of producing the material for removing neutrophils, according to claim 1 or 2, the method comprising a step of binding a compound to a knitted fabric or a woven fabric containing a fiber having a fiber diameter of 10 to 60 pm while a tension is applied to the fabric such that an elongation rate of 1 to 20% is achieved in the longitudinal direction and/or transverse direction.

Documents

Application Documents

# Name Date
1 202447055963-STATEMENT OF UNDERTAKING (FORM 3) [23-07-2024(online)].pdf 2024-07-23
2 202447055963-REQUEST FOR EXAMINATION (FORM-18) [23-07-2024(online)].pdf 2024-07-23
3 202447055963-PROOF OF RIGHT [23-07-2024(online)].pdf 2024-07-23
4 202447055963-PRIORITY DOCUMENTS [23-07-2024(online)].pdf 2024-07-23
5 202447055963-FORM 18 [23-07-2024(online)].pdf 2024-07-23
6 202447055963-FORM 1 [23-07-2024(online)].pdf 2024-07-23
7 202447055963-DRAWINGS [23-07-2024(online)].pdf 2024-07-23
8 202447055963-DECLARATION OF INVENTORSHIP (FORM 5) [23-07-2024(online)].pdf 2024-07-23
9 202447055963-COMPLETE SPECIFICATION [23-07-2024(online)].pdf 2024-07-23
10 202447055963-FORM-26 [25-07-2024(online)].pdf 2024-07-25
11 202447055963-FORM 3 [12-12-2024(online)].pdf 2024-12-12