TITLE: Novel anthranilamides, their use as insecticide and processes for preparing the same.

FIELD OF THE INVENTION:

The present invention relates to novel anthranilamides, to their use as insecticides and acaricides, to their combination with other active compounds, and to processes for their preparation.

BACKGROUND:

Anthranilic acid derivatives having insecticidal properties have already been described in the literature. For example in W02001070671, W02003015518, W02003015519, W02003016284,

W 02003024222, W02003016282, W02003016283, W02003062226, W02003027099, W 02004027042, W02004033468, WO 2004046129, W02004067528, W02005118552, W02005077934, W02005085234, W02006023783, W02006000336, W02006040113, W02006062978, W02006111341, W02007009661, W02007006670, W 02007020050, W02007024833, W02007020877, W02007144100, W02007043677, W02007093402, W02008010897, W02008070158, W02008072743, W02008072745, W02008082502, W02008126889, W02008126890, W02008126933, WO2010069502, WO2011157778, WO2011157654, WO2011157651, WO2011157663, WO2011157664, W02012010525, WO2012004221, WO2013007604, W02013030100, W02014079820, WO2014135588,

CN103450154, CN106588870 and CN106810535 the various anthranilic acid derivatives have been described.

The active compounds reported in the above literature have disadvantages in certain aspects, such as that they exhibit a narrow spectrum of application or they do not have satisfactory insecticidal or acaricidal activity.

SUMMARY:

The present invention relates to anthranilamides which have now been found to be advantages over the compounds reported in the literature in either of improved insecticidal or acaricidal activity, biological or environmental properties, broader spectrum of application or enhanced plant compatibility.

The anthranilamides of the present invention can be used in combination with other biologically active compounds for improving the efficacy particularly against insects which are difficult to control. The present invention also relates to a plurality of processes for the preparation of anthranilamides. Accordingly, the present invention provides novel anthranilamides of Formula I,

wherein,

the definition of W1, W2, B1, B2, D, Z1, E, R1, R3, R4, m is as described in the following description.

DETAILED DESCRIPTION OF THE INVENTION:

DEFINITIONS:

The definitions provided herein for the terminologies used in the present disclosure are for illustrative purpose only and in no manner limit the scope of the present invention disclosed in the present disclosure.

As used herein, the terms “comprises”, “comprising”, “includes”, “including”, “has”, “having”, “contains”,“containing”,“characterized by” or any other variation thereof, are intended to cover a non-exclusive inclusion, subject to any limitation explicitly indicated. For example, a composition, mixture, process or method that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, mixture, process or method.

The transitional phrase“consisting of’ excludes any element, step or ingredient not specified. If in the claim, such would close the claim to the inclusion of materials other than those recited except for impurities ordinarily associated therewith. When the phrase“consisting of’ appears in a clause of the body of a claim, rather than immediately following the preamble, it limits only the element set forth in that clause; other elements are not excluded from the claim as a whole.

The transitional phrase“consisting essentially of’ is used to define a composition or method that includes materials, steps, features, components or elements, in addition to those literally disclosed, provided that these additional materials, steps, features, components or elements do not materially affect the basic and novel characteristic(s) of the claimed invention. The term“consisting essentially of’ occupies a middle ground between“comprising” and“consisting of’.

Further, unless expressly stated to the contrary,“or” refers to an inclusive“or” and not to an exclusive “or”. For example, a condition A“or” B is satisfied by any one of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and both A and B are true (or present).

Also, the indefinite articles“a” and“an” preceding an element or component of the present invention are intended to be nonrestrictive regarding the number of instances (i.e. occurrences) of the element or component. Therefore“a” or“an” should be read to include one or at least one, and the singular word form of the element or component also includes the plural unless the number is obviously meant to be singular.

As referred to in this disclosure, the term“invertebrate pest” includes arthropods, gastropods and nematodes of economic importance as pests. The term“arthropod” includes insects, mites, spiders, scorpions, centipedes, millipedes, pill bugs and symphylans. The term“gastropod” includes snails, slugs and other Stylommatophora. The term“nematode” refers to a living organism of the Phylum Nematoda. The term ''helminths'' includes roundworms, heartworms, phytophagous nematodes (Nematoda), flukes (Tematoda), acanthocephala and tapeworms (Cestoda).

In the context of this disclosure“invertebrate pest control” means inhibition of invertebrate pest development (including mortality, feeding reduction, and/or mating disruption), and related expressions are defined analogously.

The term“agronomic” refers to the production of field crops such as for food and fiber and includes the growth of corn, soybeans and other legumes, rice, cereal (e.g., wheat, oats, barley, rye, rice, maize), leafy vegetables (e.g., lettuce, cabbage, and other cole crops), fruiting vegetables (e.g., tomatoes, pepper, eggplant, crucifers and cucurbits), potatoes, sweet potatoes, grapes, cotton, tree fruits (e.g., pome, stone and citrus), small fruit (berries, cherries) and other specialty crops (e.g., canola, sunflower, olives).

The term “nonagronomic” refers to other than field crops, such as horticultural crops (e.g., greenhouse, nursery or ornamental plants not grown in a field), residential, agricultural, commercial and industrial structures, turf (e.g., sod farm, pasture, golf course, lawn, sports field, etc.), wood products, stored product, agro-forestry and vegetation management, public health (i.e. human) and animal health (e.g., domesticated animals such as pets, livestock and poultry, undomesticated animals such as wildlife) applications.

Nonagronomic applications include protecting an animal from an invertebrate parasitic pest by administering a parasiticidally effective (i.e. biologically effective) amount of a compound of the present invention, typically in the form of a composition formulated for veterinary use, to the animal to be protected. As referred to in the present disclosure and claims, the terms“parasiticidal” and “parasiticidally” refers to observable effects on an invertebrate parasite pest to provide protection of an animal from the pest. Parasiticidal effects typically relate to diminishing the occurrence or activity of the target invertebrate parasitic pest. Such effects on the pest include necrosis, death, retarded growth, diminished mobility or lessened ability to remain on or in the host animal, reduced feeding and inhibition of reproduction. These effects on invertebrate parasite pests provide control (including prevention, reduction or elimination) of parasitic infestation or infection of the animal.

The compounds of the present disclosure may be present either in pure form or as mixtures of different possible isomeric forms such as stereoisomers or constitutional isomers. The various stereoisomers include enantiomers, diastereomers, chiral isomers, atropisomers, conformers, rotamers, tautomers, optical isomers, polymorphs, and geometric isomers. Any desired mixtures of these isomers fall within the scope of the claims of the present disclosure. One skilled in the art will appreciate that one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other isomer(s) or when separated from the other isomer(s). Additionally, the person skilled in the art knows processes or methods or technology to separate, enrich, and/or to selectively prepare said isomers.

The meaning of various terms used in the description shall now be illustrated.

The term“alkyl”, used either alone or in compound words such as“alkylthio” or“haloalkyl” or -N(alkyl) or alkylcarbonylalkyl or alkylsuphonylamino includes straight-chain or branched Ci to C24 alkyl, preferably Ci to C15 alkyl, more preferably Ci to C10 alkyl, most preferably Ci to C6 alkyl. Non limiting examples of alkyl include methyl, ethyl, propyl, 1 -methyl ethyl, butyl, 1 -methylpropyl, 2-methylpropyl, 1,1 -dimethyl ethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl- 1-methylpropyl and l-ethyl-2-methylpropyl or the different isomers. If the alkyl is at the end of a composite substituent, as, for example, in alkylcycloalkyl, the part of the composite substituent at the start, for example the cycloalkyl, may be mono- or polysubstituted identically or differently and independently by alkyl. The same also applies to composite substituents in which other radicals, for example alkenyl, alkynyl, hydroxyl, halogen, carbonyl, carbonyloxy and the like, are at the end.

The term“alkenyl”, used either alone or in compound words includes straight-chain or branched C2 to C24 alkenes, preferably C2 to C15 alkenes, more preferably C2 to C10 alkenes, most preferably C2 to C6 alkenes. Non limiting examples of alkenes include ethenyl, 1-propenyl, 2-propenyl, 1 -methyl ethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1 -methyl- 1-propenyl, 2-methyl-l-propenyl, l-methyl-2 -propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1 -methyl- 1-butenyl, 2-methyl- 1-butenyl, 3-methyl-l-butenyl, l-methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, l-methyl-3-butenyl, 2-methyl-3-butenyl, 3-methyl-3-butenyl, l, l-dimethyl-2-propenyl, 1,2-dimethyl- 1-propenyl, l,2-dimethyl-2 -propenyl, 1 -ethyl- 1-propenyl, l-ethyl-2 -propenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1 -methyl- 1-pentenyl, 2-methyl- 1-pentenyl, 3-methyl- 1-pentenyl, 4-methyl-l-pentenyl, l-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4-methyl-2-pentenyl, 1-methyl-3-pentenyl, 2-methyl-3-pentenyl, 3-methyl-3-pentenyl, 4- methyl-3 -pentenyl, l-methyl-4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1 , 1 -dimethyl-2-butenyl, l,l-dimethyl-3-butenyl, 1,2-dimethyl-l-butenyl, l,2-dimethyl-2-butenyl, l,2-dimethyl-3-butenyl, 1,3-dimethyl- 1-butenyl, l,3-dimethyl-2-butenyl, l,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl- 1-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 3,3-dimethyl-l-butenyl, 3,3-dimethyl-2-butenyl, 1-ethyl-l-butenyl, l-ethyl-2-butenyl, l-ethyl-3-butenyl, 2-ethyl- 1-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl, l,l,2-trimethyl-2-propenyl, l-ethyl-l-methyl-2-propenyl, l-ethyl-2-methyl-l-propenyl and l-ethyl-2-methyl-2-propenyl and the different isomers.“Alkenyl” also includes polyenes such as 1,2-propadienyl and 2,4-hexadienyl. This definition also applies to alkenyl as a part of a composite substituent, for example haloalkenyl and the like, unless defined specifically elsewhere.

Non limiting examples of alkynes include ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, l-methyl-2 -prop ynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, l-methyl-2 -butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-l-butynyl, 1,1 -dimethyl-2 -prop ynyl, 1-ethyl -2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1 -methyl-2 -pentynyl, l-methyl-3-pentynyl, l-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-l-pentynyl, 3-methyl-4-pentynyl, 4-methyl-l-pentynyl, 4-methyl-2-pentynyl, 1,1 -dimethyl-2 -butynyl, l,l-dimethyl-3-butynyl, l,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-l-butynyl, l-ethyl-2 -butynyl, 1-ethyl-3-butynyl, 2-ethyl-3 -butynyl and l-ethyl-l-methyl-2-propynyl and the different isomers. This definition also applies to alkynyl as a part of a composite substituent, for example haloalkynyl etc., unless specifically defined elsewhere. The term“ Alkynyl” can also include moieties comprised of multiple triple bonds such as 2,5-hexadiynyl.

The term“cycloalkyl” means alkyl closed to form a ring. Non limiting examples include cyclopropyl, cyclopentyl and cyclohexyl. This definition also applies to cycloalkyl as a part of a composite substituent, for example cycloalkylalkyl etc., unless specifically defined elsewhere.

The term “cycloalkenyl” means alkenyl closed to form a ring including monocyclic, partially unsaturated hydrocarbyl groups. Non limiting examples include cyclopropenyl, cyclopentenyl and

cyclohexenyl. This definition also applies to cycloalkenyl as a part of a composite substituent, for example cycloalkenylalkyl etc., unless specifically defined elsewhere.

The term “cycloalkynyl” means alkynyl closed to form a ring including monocyclic, partially unsaturated groups. Non limiting examples include cyclopropynyl, cyclopentynyl and cyclohexynyl. This definition also applies to cycloalkynyl as a part of a composite substituent, for example cycloalkynylalkyl etc., unless specifically defined elsewhere.

The terms“cycloalkoxy”, “cycloalkenyloxy” and the like are defined analogously. Non limiting examples of cycloalkoxy include cyclopropyloxy, cyclopentyloxy and cyclohexyloxy. This definition also applies to cycloalkoxy as a part of a composite substituent, for example cycloalkoxy alkyl etc., unless specifically defined elsewhere.

The term“halogen”, either alone or in compound words such as “haloalkyl”, includes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as“haloalkyl”, said alkyl may be partially or fully substituted with halogen atoms which may be the same or different. Non limiting Examples of “haloalkyl” include chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl, 1, l-dichloro-2,2,2-trifluoroethyl, and l, l,l-trifluoroprop-2-yl. This definition also applies to haloalkyl as a part of a composite substituent, for example haloalkylaminoalkyl etc., unless specifically defined elsewhere.

The terms“haloalkenyl”,“haloalkynyl” are defined analogously except that, instead of alkyl groups, alkenyl and alkynyl groups are present as a part of the substituent.

The term“haloalkoxy” means straight- chain or branched alkoxy groups where some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as specified above. Non-limiting examples of haloalkoxy include chloromethoxy, bromomethoxy, dichloromethoxy, trichloromethoxy, fluoromethoxy, difluoromethoxy, trifluoromethoxy, chlorofluoromethoxy, dichlorofluoromethoxy, chlorodifluoromethoxy, 1-chloroethoxy, 1-bromoethoxy, 1 -fluoroethoxy, 2-fluoroethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, 2-chloro-2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro-2-fluoroethoxy, 2,2,2-trichloroethoxy, pentafluoroethoxy and l,l,l-trifluoroprop-2-oxy. This definition also applies to haloalkoxy as a part of a composite substituent, for example haloalkoxyalkyl etc., unless specifically defined elsewhere.

The term“haloalkylthio” means straight-chain or branched alkylthio groups where some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as specified above. Non-limiting

examples of haloalkylthio include chloromethylthio, bromomethylthio, dichloromethylthio, trichloromethylthio, fluoromethylthio, difluoromethylthio, trifluoromethylthio, chlorofluoromethylthio, dichloro fluoromethylthio, chlorodifluoromethylthio, 1 -chloroethylthio, 1-bromoethylthio, 1- fluoroethylthio, 2-fluoroethylthio, 2,2-difluoroethylthio, 2,2,2-trifluoroethylthio, 2-chloro-2- fluoroethylthio, 2-chloro-2,2-difluoroethylthio, 2,2-dichloro-2-fluoroethylthio, 2,2,2-trichloroethylthio, pentafluoroethylthio and l,l,l-trifluoroprop-2-ylthio. This definition also applies to haloalkylthio as a part of a composite substituent, for example haloalkylthioalkyl etc., unless specifically defined elsewhere.

Non limiting examples of “haloalkylsulfinyl” include CF3S(0), CChS(O), CF3CH2S(0) and CF3CF2S(0). Examples of “haloalkylsulfonyl” include CF3S(0)2, CC13S(0)2, CF3CH2S(0)2 and CF3CF2S(0)2.

The trerm“hydroxy” means -OH, Amino means -NRR, wherein R can be H or any possible substituent such as alkyl. Carbonyl means -C(O)- , carbonyloxy means -OC(O)-, sulfinyl means SO, sulfonyl means S(0)2.

The term“alkoxy” used either alone or in compound words included Ci to CM alkoxy, preferably Ci to C15 alkoxy, more preferably Ci to Cio alkoxy, most preferably Ci to C6 alkoxy. Examples of alkoxy include methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy, 1,1-dimethyl ethoxy, pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexoxy, 1,1-dimethylpropoxy, 1,2-dimethylpropoxy, 1-methylpentoxy, 2-methylpentoxy, 3-methylpentoxy, 4-methylpentoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, 1,1,2-trimethylpropoxy, 1,2,2-trimethylpropoxy, 1 -ethyl- 1-methylpropoxy and l-ethyl-2-methylpropoxy and the different isomers. This definition also applies to alkoxy as a part of a composite substituent, for example haloalkoxy, alkynylalkoxy, etc., unless specifically defined elsewhere.

The term“alkoxyalkyl” denotes alkoxy substitution on alkyl. Examples of “alkoxyalkyl” include CH3OCH2, CH3OCH2CH2, CH3CH2OCH2, CH3CH2CH2CH2OCH2 and CH3CH2OCH2CH2.

The term“alkoxyalkoxy” denotes alkoxy substitution on alkoxy.

The term“alkylthio” includes branched or straight-chain alkylthio moieties such as methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2-methylpropylthio, 1,1-dimethylethylthio, pentylthio, 1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 2,2-dimethylpropylthio, 1 -ethylpropylthio, hexylthio, 1,1-dimethylpropylthio, 1,2-dimethylpropylthio, 1-methylpentylthio, 2-methylpentylthio, 3-methylpentylthio, 4-methylpentylthio, 1,1-dimethylbutylthio, 1,2-dimethylbutylthio, 1,3-dimethylbutylthio, 2,2-dimethylbutylthio, 2,3-dimethylbutylthio, 3,3-dimethylbutylthio, 1-ethylbutylthio, 2-ethylbutylthio, 1,1,2-trimethylpropylthio, 1,2,2-trimethylpropylthio, 1 -ethyl- 1-methylpropylthio and l-ethyl-2-methylpropylthio and the different isomers.

The terms Halocycloalkyl, halocycloalkenyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkoxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, haloalkylcarbonyl, cycloalkylcarbonyl, haloalkoxylalkyl, and the like, are defined analogously to the above examples.

The term “alkylthioalkyl” denotes alkylthio substitution on alkyl. Non limiting examples of “alkylthioalkyl” include -CH2SCH2, -CH2SCH2CH2, CH3CH2SCH2, CH3CH2CH2CH2SCH2 and CH3CH2SCH2CH2. “Alkylthioalkoxy” denotes alkylthio substitution on alkoxy. The term “cycloalkylalkylamino” denotes cycloalkyl substitution on alkyl amino.

The terms alkoxyalkoxyalkyl, alkylaminoalkyl, dialkylaminoalkyl, cycloalkylaminoalkyl, cycloalkylaminocarbonyl and the like, are defined analogously to “alkylthioalkyl” or cycloalkylalkylamino.

The term“alkoxycarbonyl” is an alkoxy group bonded to a skeleton via a carbonyl group (-CO-). This definition also applies to alkoxycarbonyl as a part of a composite substituent, for example cycloalkylalkoxycarbonyl and the like, unless specifically defined elsewhere.

The term “alkoxycarbonylalkylamino” denotes alkoxy carbonyl substitution on alkyl amino. “Alkylcarbonylalkylamino” denotes alkyl carbonyl substitution on alkyl amino. The terms alkylthioalkoxycarbonyl, cycloalkylalkylaminoalkyl and the like are defined analogously.

Non limiting examples of“alkylsulfinyl” include methylsulphinyl, ethylsulphinyl, propylsulphinyl, 1-methylethylsulphinyl, butylsulphinyl, 1-methylpropylsulphinyl, 2-methylpropylsulphinyl, 1,1-dimethylethylsulphinyl, pentylsulphinyl, 1-methylbutylsulphinyl, 2-methylbutylsulphinyl, 3-methylbutylsulphinyl, 2,2-dimethylpropylsulphinyl, 1-ethylpropylsulphinyl, hexylsulphinyl, 1,1-dimethylpropylsulphinyl, 1,2-dimethylpropylsulphinyl, 1-methylpentylsulphinyl, 2-methylpentylsulphinyl, 3-methylpentylsulphinyl, 4-methylpentylsulphinyl, 1,1-dimethylbutylsulphinyl, 1,2-dimethylbutylsulphinyl, 1,3-dimethylbutylsulphinyl, 2,2-dimethylbutylsulphinyl, 2,3-dimethylbutylsulphinyl, 3,3-dimethylbutylsulphinyl, 1-ethylbutylsulphinyl, 2-ethylbutylsulphinyl, 1, 1,2-trimethylpropylsulphinyl, 1,2,2-trimethylpropylsulphinyl, 1 -ethyl- 1-methylpropylsulphinyl and l-ethyl-2-methylpropylsulphinyl and the different isomers. The term“arylsulfinyl” includes Ar-S(O), wherein Ar can be any carbocyle or heterocylcle. This definition also applies to alkylsulphinyl as a part of a composite substituent, for example haloalkylsulphinyl etc., unless specifically defined elsewhere.

Non limiting examples of“alkylsulfonyl” include methylsulphonyl, ethylsulphonyl, propylsulphonyl, 1 -methyl ethylsulphonyl, butylsulphonyl, 1 -methylpropylsulphonyl, 2-methylpropylsulphonyl, 1,1-dimethylethylsulphonyl, pentylsulphonyl, 1-methylbutylsulphonyl, 2-methylbutylsulphonyl, 3-methylbutylsulphonyl, 2,2-dimethylpropylsulphonyl, 1-ethylpropylsulphonyl, hexylsulphonyl, 1,1-dimethylpropylsulphonyl, 1,2-dimethylpropylsulphonyl, 1-methylpentylsulphonyl, 2-methylpentylsulphonyl, 3-methylpentylsulphonyl, 4-methylpentylsulphonyl, 1,1-dimethylbutylsulphonyl, 1,2-dimethylbutylsulphonyl, 1,3-dimethylbutylsulphonyl, 2,2-dimethylbutylsulphonyl, 2,3-dimethylbutylsulphonyl, 3,3-dimethylbutylsulphonyl, 1-ethylbutylsulphonyl, 2-ethylbutylsulphonyl, 1, 1,2-trimethylpropylsulphonyl, 1,2,2-trimethylpropylsulphonyl, 1 -ethyl- 1-methylpropylsulphonyl and 1-ethyl -2-methylpropylsulphonyl and the different isomers. The term“arylsulfonyl” includes Ar-S(0)2, wherein Ar can be any carbocyle or heterocylcle. This definition also applies to alkylsulphonyl as a part of a composite substituent, for example alkylsulphonylalkyl etc., unless defined elsewhere.

The term“alkylamino”,“dialkylamino”, and the like, are defined analogously to the above examples.

The term“carbocycle” includes“aromatic carbocyclic ring system” and“nonaromatic carbocylic ring system” or polycyclic or bicyclic (spiro, fused, bridged, nonfused) ring compounds in which ring may be aromatic or non-aromatic (where aromatic indicates that the Huckel rule is satisfied and non aromatic indicates that the Huckel rule is not statisfied).

The term“hetero” in connection with rings refers to a ring in which at least one ring atom is not carbon and which can contain 1 to 4 heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulfur, provided that each ring contains no more than 4 nitrogens, no more than 2 oxygens and no more than 2 sulfurs.

The term “heteroaryl” or “aromatic heterocyclic” means 5 or 6-membered, fully unsaturated monocyclic ring system containing one to four heteroatoms from the group of oxygen, nitrogen and sulphur; if the ring contains more than one oxygen atom, they are not directly adjacent; 5-membered heteroaryl containing one to four nitrogen atoms or one to three nitrogen atoms and one sulphur or oxygen atom: 5-membered heteroaryl groups which, in addition to carbon atoms, may contain one to four nitrogen atoms or one to three nitrogen atoms and one sulphur or oxygen atom as ring members, for example (but not limited thereto) furyl, thienyl, pyrrolyl, isoxazolyl, isothiazolyl, pyrazolyl, oxazolyl, thiazolyl, imidazolyl, 1,2,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1,2,4-triazolyl, 1,3,4-oxadiazolyl, 1,3,4-thiadiazolyl, 1,3,4-triazolyl, tetrazolyl; nitrogen-bonded 5-membered heteroaryl containing one to four nitrogen atoms, or benzofused nitrogen-bonded 5-membered heteroaryl containing one to three nitrogen atoms: 5-membered heteroaryl groups which, in addition to carbon atoms, may contain one to four nitrogen atoms or one to three nitrogen atoms as ring members and in which two adjacent carbon ring members or one nitrogen and one adjacent carbon ring member may be bridged by a buta-

l,3-diene-l,4-diyl group in which one or two carbon atoms may be replaced by nitrogen atoms, where these rings are attached to the skeleton via one of the nitrogen ring members, for example (but not limited to) 1-pyrrolyl, 1-pyrazolyl, 1,2,4-triazol-l- yl, 1-imidazolyl, 1,2,3-triazol-l-yl and 1,3,4-triazol-1-yL.

6-membered heteroaryl which contains one to four nitrogen atoms: 6-membered heteroaryl groups which, in addition to carbon atoms, may contain, respectively, one to three and one to four nitrogen atoms as ring members, for example (but not limited thereto) 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 3-pyridazinyl, 4-pyridazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2-pyrazinyl, l,3,5-triazin-2-yl, l,2,4-triazin-3-yl and l,2,4,5-tetrazin-3-yl; benzofused 5-membered heteroaryl containing one to three nitrogen atoms or one nitrogen atom and one oxygen or sulphur atom: for example (but not limited to) indol-l-yl, indol-2-yl, indol-3-yl, indol-4-yl, indol-5-yl, indol-6-yl, indol-7-yl, benzimidazol-l-yl, benzimidazol-2-yl, benzimidazol-4-yl, benzimidazol-5-yl, indazol-l-yl, indazol-3-yl, indazol-4-yl, indazol-5-yl, indazol-6-yl, indazol-7-yl, indazol-2-yl, l-benzofuran-2-yl, 1-benzofuran-3-yl, l-benzofuran-4-yl, l-benzofuran-5-yl, 1-benzofuran- 6-yl, l-benzofuran-7-yl, 1-benzothiophen-2-yl, l-benzothiophen-3-yl, l-benzothiophen-4-yl, 1- benzothiophen-5-yl, 1-benzothiophen-6-yl, l-benzothiophen-7-yl, l,3-benzothiazol-2-yl, 1,3- benzothiazol-4-yl, 1,3-benzothiazol-5-yl, l,3-benzothiazol-6-yl, l,3-benzothiazol-7-yl, l,3-benzoxazol-2-yl, l,3-benzoxazol-4-yl, l,3-benzoxazol-5-yl, l,3-benzoxazol-6-yl and l,3-benzoxazol-7-yl; benzofused 6-membered heteroaryl which contains one to three nitrogen atoms: for example (but not limited to) quinolin-2-yl, quinolin-3-yl, quinolin-4-yl, quinolin-5-yl, quinolin-6-yl, quinolin-7-yl, quinolin-8-yl, isoquinolin-1-yl, isoquinolin-3-yl, isoquinolin-4-yl, isoquinolin-5-yl, isoquinolin-6-yl, isoquinolin-7-yl and isoquinolin-8-yl.

This definition also applies to heteroaryl as a part of a composite substituent, for example heteroarylalkyl etc., unless specifically defined elsewhere.

The term“aromatic” indicates that the Huckel rule is satisfied and the term“non-aromatic” indicates that the Huckel rule is not satisfied.

The term“heterocycle” or“heterocyclic” includes“aromatic heterocycle” or“heteroaryl ring system” and“nonaromatic heterocycle ring system” or polycyclic or bicyclic (spiro, fused, bridged, non-fused) ring compounds in which ring may be aromatic or non-aromatic, wherein the heterocycle ring contains at least one heteroatom selected from N, O, S(0)o-2, and or C ring member of the heterocycle may be replaced by C(=0), C(=S), C(=CR*R*) and C=NR*, * indicates integers.

The term “non-aromatic heterocycle” or “non-aromatic heterocyclic” means three- to fifteen-membered, preferably three- to twelve-membered, saturated or partially unsaturated heterocycle containing one to four heteroatoms from the group of oxygen, nitrogen and sulphur: mono, bi- or

tricyclic heterocycles which contain, in addition to carbon ring members, one to three nitrogen atoms and/or one oxygen or sulphur atom or one or two oxygen and/or sulphur atoms; if the ring contains more than one oxygen atom, they are not directly adjacent; for example (but not limited to) oxetanyl, oxiranyl, aziridinyl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydrothienyl, 3-tetrahydrothienyl, 1 -pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 3-isoxazolidinyl, 4-isoxazolidinyl, 5-isoxazolidinyl, 3-isothiazolidinyl, 4-isothiazolidinyl, 5-isothiazolidinyl, 1-pyrazolidinyl, 3-pyrazolidinyl, 4-pyrazolidinyl, 5-pyrazolidinyl, 2-oxazolidinyl, 4-oxazolidinyl, 5-oxazolidinyl, 2-thiazolidinyl, 4-thiazolidinyl, 5-thiazolidinyl, 1-imidazolidinyl, 2-imidazolidinyl, 4-imidazolidinyl, 1,2,4-oxadiazolidin-3-yl, l,2,4-oxadiazolidin-5-yl, l,2,4-thiadiazolidin-3-yl, l,2,4-thiadiazolidin-5-yl, 1,2,4-triazolidin-l-yl, l,2,4-triazolidin-3-yl, l,3,4-oxadiazolidin-2-yl, l,3,4-thiadiazolidin-2-yl, 1,3,4-triazolidin-l-yl, l,3,4-triazolidin-2-yl, 2,3-dihydrofur-2-yl, 2,3-dihydrofur-3-yl, 2,4-dihydrofur-2-yl,

2.4-dihydrofur-3-yl, 2,3-dihydrothien-2-yl, 2,3-dihydrothien-3-yl, 2,4-dihydrothien-2-yl, 2,4-dihydrothien-3-yl, pyrrolinyl, 2-pyrrolin-2-yl, 2-pyrrolin-3-yl, 3-pyrrolin-2-yl, 3-pyrrolin-3-yl, 2-isoxazolin-3-yl, 3-isoxazolin-3-yl, 4-isoxazolin-3-yl, 2-isoxazolin-4-yl, 3-isoxazolin-4-yl, 4-isoxazolin-4-yl, 2-isoxazolin-5-yl, 3-isoxazolin-5-yl, 4-isoxazolin-5-yl, 2-isothiazolin-3-yl, 3-isothiazolin-3-yl, 4-isothiazolin-3-yl, 2-isothiazolin-4-yl, 3-isothiazolin-4-yl, 4-isothiazolin-4-yl, 2-isothiazolin-5-yl, 3-isothiazolin-5-yl, 4-isothiazolin-5-yl, 2,3-dihydropyrazol-l-yl, 2,3-dihydropyrazol-2-yl, 2,3-dihydropyrazol-3-yl, 2,3-dihydropyrazol-4-yl, 2,3-dihydropyrazol-5-yl, 3,4-dihydropyrazol- 1-yl, 3,4-dihydropyrazol-3-yl, 3,4-dihydropyrazol-4-yl, 3,4-dihydropyrazol-5-yl, 4,5-dihydropyrazol-l-yl, 4,5-dihydropyrazol-3-yl, 4,5-dihydropyrazol-4-yl, 4,5-dihydropyrazol-5-yl, 2,3-dihydrooxazol-2-yl, 2,3-dihydrooxazol-3-yl, 2,3-dihydrooxazol-4-yl, 2,3-dihydrooxazol-5-yl, 3,4-dihydrooxazol-2-yl,

3.4-dihydrooxazol-3-yl, 3,4-dihydrooxazol-4-yl, 3,4-dihydrooxazol-5-yl, 3,4-dihydrooxazol-2-yl, 3,4-dihydrooxazol-3-yl, 3,4-dihydrooxazol-4-yl, piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, pyrazynyl, morpholinyl, thiomorphlinyl, l,3-dioxan-5-yl, 2-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tetrahydrothienyl, 3-hexahydropyridazinyl, 4-hexahydropyridazinyl, 2-hexahydropyrimidinyl, 4-hexahydropyrimidinyl, 5-hexahydropyrimidinyl, 2-piperazinyl, l,3,5-hexahydrotriazin-2-yl, 1,2,4-hexahydrotriazin-3-yl, cycloserines, 2,3,4,5-tetrahydro[lH]azepin-l- or -2- or -3- or -4- or -5- or -6-or -7- yl, 3,4,5,6-tetra-hydro[2H]azepin-2- or -3- or -4- or -5- or -6- or-7-yl, 2, 3, 4, 7-tetrahydro[lH]azepin-l- or -2- or -3- or -4- or -5- or -6- or-7- yl, 2,3,6,7-tetrahydro[lH]azepin-l- or - 2- or -3- or -4- or -5- or -6- or -7- yl, hexahydroazepin-1- or -2- or -3- or -4- yl, tetra- and hexahydrooxepinyl such as 2,3,4,5-tetrahydro[l H]oxepin-2- or -3- or -4- or -5- or -6- or -7- yl, 2,3,4,7-tetrahydro[lH]oxepin-2- or -3- or -4- or -5- or -6- or -7- yl, 2,3,6,7-tetrahydro[lH]oxepin-2-or -3- or -4- or -5- or -6- or -7- yl, hexahydroazepin-1- or -2- or -3- or -4- yl, tetra- and hexahydro-1,3-diazepinyl, tetra- and hexahydro-l,4-diazepinyl, tetra- and hexahydro-l,3-oxazepinyl, tetra- and hexahydro-l,4-oxazepinyl, tetra- and hexahydro-l,3-dioxepinyl, tetra- and hexahydro-l,4-dioxepinyl. This definition also applies to heterocyclyl as a part of a composite substituent, for example heterocyclylalkyl etc., unless specifically defined elsewhere.

The term“trialkylsilyl” includes 3 branched and/or straight-chain alkyl radicals attached to and linked through a silicon atom such as trimethylsilyl, triethylsilyl and t-butyl-dimethylsilyl. The term “halotrialkylsilyl” denotes at least one of the three alkyl radicals is partially or fully substituted with halogen atoms which may be the same or different. The term“alkoxytrialkylsilyl” denotes at least one of the three alkyl radicals is substituted with one or more alkoxy radicals which may be the same or different. The term“trialkylsilyloxy” denotes a trialkylsilyl moiety attached through oxygen.

Non limiting examples of“alkylcarbonyl” include C(0)CH3, C(0)CH2CH2CH3 and C(0)CH(CH3)2. Examples of “alkoxycarbonyl” include CH3OC(=0), CH3CH20C(=0), CH3CH2CH20C(=0), (CH3)2CH0C(=0) and the different butoxy -or pentoxycarbonyl isomers. Examples of “alkylaminocarbonyl” include CH3NHC(=0), CH3CH2NHC(=0), CH3CH2CH2NHC(=0), (CH3)2CHNHC(=0) and the different butylamino -or pentylaminocarbonyl isomers. Non limiting examples of “dialkylaminocarbonyl” include (CH3)2NC(=0), (CH3CH2)2NC(=0),

CH3CH2(CH3)NC(=0), CH3CH2CH2(CH3)NC(=0) and (CH3)2CHN(CH3)C(=0). Examples of “alkoxyalkylcarbonyl” include CH30CH2C(=0), CH30CH2CH2C(=0), CH3CH20CH2C(=0),

CH3CH2CH2CH20CH2C(=0) and CTTCHzOCHzCHzCt^O). Non limiting examples of “alkylthioalkyl carbonyl” include CH3SCH2C(=0), CH3SCH2CH2C(=0), CH3CH2SCH2C(=0), CH3CH2CH2CH2SCH2C(=0) and CH3CH2SCH2CH2C(=0). The term haloalkylsufonylaminocarbonyl, alkylsulfonylaminocarbonyl, alkylthioalkoxycarbonyl, alkoxycarbonylalkyl amino and the like are defined analogously

Non limiting examples of “alkylaminoalkylcarbonyl” include CH3NHCH2C(=0), CH3NHCH2CH2C(=0), CH3CH2NHCH2C(=0), CH3CH2CH2CH2NHCH2C(=0) and CH3CH2NHCH2CH2C(=0).

The term“amide” means A-R'C=ONR"-B, wherein R' and R" indicates substituents and A and B indicate any group.

The term“thioamide” means A-R'C=SNR"-B, wherein R' and R" indicates substituents and A and B indicate any group.

The total number of carbon atoms in a substituent group is indicated by the“Ci-Cj” prefix where i and j are numbers from 1 to 21. For example, C1-C3 alkylsulfonyl designates methylsulfonyl through propylsulfonyl; C2 alkoxyalkyl designates CH3OCH2; C3 alkoxyalkyl designates, for example, G-TCH/OCTE), CH3OCH2CH2 or CH3CH2OCH2; and C4 alkoxyalkyl designates the various isomers of an alkyl group substituted with an alkoxy group containing a total of four carbon atoms, examples including CH3CH2CH2OCH2 and CH3CH2OCH2CH2. In the above recitations, when a compound of Formula I is comprised of one or more heterocyclic rings, all substituents are attached to these rings through any available carbon or nitrogen by replacement of a hydrogen on said carbon or nitrogen.

When a compound is substituted with a substituent bearing a subscript that indicates the number of said substituents can exceed 1, said substituents (when they exceed 1) are independently selected from the group of defined substituents. Further, when the subscript m in (R)m indicates an integer ranging from for example 0 to 4 then the number of substituents may be selected from the integers between 0 and 4 inclusive.

When a group contains a substituent which can be hydrogen, then, when this substituent is taken as hydrogen, it is recognized that said group is being un-substituted.

The embodiments herein and the various features and advantageous details thereof are explained with reference to the non-limiting embodiments in the description. Descriptions of well-known components and processing techniques are omitted so as to not unnecessarily obscure the embodiments herein. The examples used herein are intended merely to facilitate an understanding of ways in which the embodiments herein may be practiced and to further enable those of skilled in the art to practice the embodiments herein. Accordingly, the examples should not be construed as limiting the scope of the embodiments herein.

The description of the specific embodiments will so fully reveal the general nature of the embodiments herein that others can, by applying current knowledge, readily modify and/or adapt for various applications such specific embodiments without departing from the generic concept, and, therefore, such adaptations and modifications should and are intended to be comprehended within the meaning and range of equivalents of the disclosed embodiments. It is to be understood that the phraseology or terminology employed herein is for the purpose of description and not of limitation. Therefore, while the embodiments herein have been described in terms of preferred embodiments, those skilled in the art will recognize that the embodiments herein can be practiced with modification within the spirit and scope of the embodiments as described herein.

Any discussion of documents, acts, materials, devices, articles and the like that has been included in this specification is solely for the purpose of providing a context for the disclosure. It is not to be taken as an admission that any or all of these matters form a part of the prior art base or were common general knowledge in the field relevant to the disclosure as it existed anywhere before the priority date of this application.

The numerical values mentioned in the description and the description/claims though might form a critical part of the present invention of the present invention, any deviation from such numerical values shall still fall within the scope of the present invention if that deviation follows the same scientific principle as that of the present invention disclosed in the present invention.The inventive compounds of the present invention may, if appropriate, be present as mixtures of different possible isomeric forms, especially of stereoisomers, for example E and Z, threo and erythro, and also optical isomers, but if appropriate also of tautomers. Both the E and the Z isomers, and also the threo and erythro isomers, and the optical isomers, any desired mixtures of these isomers and the possible tautomeric forms are disclosed and claimed.

WE CLAIM:

1. A compound of formula I,

wherein,

R1 is NR10Rn;

R10 is selected from hydrogen, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C4-C8 cycloalkylalkyl, Ci-Ce haloalkyl, C3-C6 halocycloalkyl, Ci-Ce alkoxy, or Ci-Ce haloalkoxy;

R11 is 5-, 6- or 7- membered heterocyclic ring attached to N of R1 through a C atom of respective ring, said heterocyclic ring containing at least two hetero atoms selected from N, O and S(0)o-2; and at least one C of the heterocyclic ring may be optionally replaced with C, C(=0), C(=S), C(=CR6aR7a) and C(=NR5); said heterocyclic ring may be optionally substituted with one or more different or identical R16a;

wherein R16a is selected from the group of hydrogen, halogen, cyano, nitro, hydroxy, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, Ci-Ce haloalkyl, Ci-Ce alkoxyalkyl, Ci-Ce hydroxyalkyl, C2- C6 haloalkenyl, C2-C6 haloalkynyl, C3-C6 halocycloalkyl, Ci-Ce alkoxy, Ci-Ce haloalkoxy, Ci-Ce haloalkoxycarbonyl, Ci-Ce alkylthio, Ci-Ce haloalkylthio, Ci-Ce haloalkylsulfinyl, Ci-Ce haloalkylsulfonyl, Ci-Ce alkylsulfinyl, Ci-Ce alkylsulfonyl, Ci-Ce alkylamino, Ci-Ce dialkylamino, C3-C6 cycloalkylamino, Ci-Ce alkyl-C3-C6-cycloalkylamino, Ci-Ce alkylcarbonyl, Ci-Ce alkoxycarbonyl, Ci-Ce alkylaminocarbonyl, Ci-Ce dialkylaminocarbonyl, Ci-Ce alkoxycarbonyloxy, Ci-Ce alkylaminocarbonyloxy, Ci-Ce dialkylaminocarbonyloxy or Ci-Ce trialkylsilyl,

Rn is hydrogen, Ci-Cs alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C5-C15 multicyclic ring or ring system, C3-C8 cycloalkylalkyl, C3-C10 heterocyclic ring, or NRcRd; wherein the heteroatoms of the heterocyclic ring are selected from N, O, and S(0)o-2, and C ring member of the heterocyclic ring may be optionally replaced with C(=0) and C(=S); each optionally substituted with one or more different or identical substituents selected from halogen, cyano, nitro, hydroxy, Ci-Ce alkyl, C3-C8 cycloalkyl, Ci-Ce alkoxy, Ci-Ce haloalkoxy, Ci-Ce alkylthio, Ci-Ce alkylsulfinyl, Ci-C6 alkylsulfonyl, Ci-Ce alkoxycarbonyl, Ci-Ce alkylcarbonyl, Ci-Ce tri alkylsilyl, C3-C6 heterocyclic ring; wherein the heteroatoms of the heterocyclic ring are selected from N, O, and S(0)o-2, and C ring member of the heterocyclic ring may be optionally replaced with C(=0) and C(=S); phenyl, benzoyl, phenoxy, 5- or 6- membered heteroaromatic rings;

each phenyl, benzoyl, phenoxy and 5- or 6 membered heteroaromatic ring is optionally substituted with one or more different or identical substituents independently selected from Ci-Ce alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, Ci-Ce haloalkyl, C2-C4 haloalkenyl, C2-C4 haloalkynyl, C3-C6 halocycloalkyl, halogen, cyano, nitro, Ci-Ce alkoxy, Ci-Ce haloalkoxy, Ci-Ce alkylthio, Ci-Ce alkylsulfinyl, Ci-Ce alkylsulfonyl, Ci-Ce alkylamino, Ci-Cs dialkylamino, C3-C8 cycloalkylamino, C3-Cs-cycloalkyl- Cl-C6-alkylamino, Ci-Ce alkylcarbonyl, Ci-Ce alkoxycarbonyl, Ci-Ce alkylaminocarbonyl, Ci-Cs dialkylaminocarbonyl and Ci-Ce tri alkylsil yl ; Ci- C6 alkoxy; Ci-Ce alkylamino; Ci-Cs dialkylamino; C3-C8 cycloalkylamino; Ci-Ce alkoxycarbonyl or Ci-Ce alkylcarbonyl; or

R10 and Rn together with N atom to which they are attached may form a 3 to 8-membered heterocyclic ring; wherein the heteroatoms of the heterocyclic ring are selected from N, O, and S(0)o-2, and C ring member of the heterocyclic ring may be optionally replaced with C(=0), C(=S) or C(=NR5a); said heterocyclyl ring may be optionally substituted with one or more substituent R16b;

wherein R16b is selected from the group consisting of hydrogen, halogen, cyano, nitro, hydroxy, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, Ci-Ce haloalkyl, Ci-Ce alkoxyalkyl, Ci-Ce hydroxyalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C6 halocycloalkyl, Ci-Ce alkoxy, Ci-Ce haloalkoxy, Ci-Ce haloalkoxycarbonyl, Ci-Ce alkylthio, Ci-Ce haloalkylthio, Ci-Ce haloalkylsulfinyl, Ci-Ce haloalkylsulfonyl, Ci-Ce alkylsulfinyl, Ci-Ce alkylsulfonyl, Ci-Ce alkylamino, Ci-Ce dialkylamino, C3- C6 cycloalkylamino, Ci-Ce alkyl-C3-C6-cycloalkylamino, Ci-Ce alkylcarbonyl, Ci-Ce alkoxycarbonyl, Ci-Ce alkylaminocarbonyl, Ci-Ce dialkylaminocarbonyl, Ci-Ce alkoxycarbonyloxy, Ci-Ce

alkylaminocarbonyloxy, Ci-Ce dialkylaminocarbonyloxy and Ci-Ce tri alkyl sil yl ;

R12 and R13 are independently selected from hydrogen, C1-C10 alkyl, C3-C8 cycloalkyl, C2-C10 alkenyl, C2-C10 alkynyl, or Ci-Ce alkylcarbonyl, wherein said aliphatic and cycloaliphatic groups may be optionally substituted with one or more different or identical Re,

each Re is independently selected from halogen, cyano, nitro, hydroxy, -SH, - SCN, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, or C3-C8 cycloalkyl, wherein one or more CH2 groups may be replaced by a C(=0) group, said aliphatic and cycloaliphatic groups may be optionally substituted with halogen, Ci-Ce alkoxy; Ci-Ce alkoxy, Ci-Ce haloalkoxy, Ci-Ce alkylthio, Ci-Ce alkylsulfinyl, Ci-Ce alkylsulfonyl, Ci-C6 haloalkylthio, -ORa, -NRcRd, -S(0)aRa, - )Ra, -C(=S)NRcRd,
phenyl, benzyl, phenoxy and 4 - to 6- membered heterocyclic ring; each of phenyl, benzyl, phenoxy and 4 - to 6- membered heterocyclic ring optionally substituted with halogen, Ci-Ce alkyl, Ci-Ce haloalkyl, Ci-Ce alkoxy and Ci-Ce haloalkoxy; or two vicinal radicals Re taken together form a group =0, =CH(CI-C6 alkyl), =C(Ci-C6 alkyl)Ci-C4-alkyl, =N(Ci-C6-alkyl) or =NO(Ci-C6-alkyl); or R12 and R13 represent phenyl, benzyl, phenoxy and 4 - to 6- membered heterocyclic ring optionally substituted with halogen, cyano, nitro, hydroxy, -SH, -SCN, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, or C3-C8 cycloalkyl, wherein one or more C¾ groups may be replaced by a C(=0) group, said aliphatic and cycloaliphatic groups may be optionally substituted with halogen, Ci-Ce alkoxy; Ci-Ce alkoxy, Ci-Ce haloalkoxy, Ci-Ce alkylthio, Ci-Ce alkylsulfinyl, Ci-Ce alkylsulfonyl, Ci-Ce haloalkylthio, -ORa, -NRcRd, -S(0)aRa, -S(0)aNRcRd, -C(=0)Ra, -C(=0)NRcRd, - C(=0)0Rb, -C(=S)Ra, -C(=S)NRcRd, -C(=S)ORb, -C(=S)SRb, -C(=NRc)Rb, or - C(=NRc)NRcRd; or

R12 and R13 together represent a C2-C7 alkylene, C2-C7 alkenylene, C6-C9 alkynylene, 3 to 10 membered ring or ring system together with the sulfur atom to which they are attached, wherein 1 to 4 of the C¾ groups in the C2-C7 alkylene chain or 1 to 4 of any of the CH2 or CH groups in the C2-C7 alkenylene chain or 1 to 4 of any of the CH2 groups in the C6-C9 alkynylene chain may be replaced by 1 to 4 groups independently selected from C(=0), C(=S), O, S, N, NO, SO, SO2 or NH, and wherein the carbon and/or nitrogen atoms in the C2-C7 alkylene, C2-C7 alkenylene or C6-C9 alkynylene ring may be optionally substituted with one or more different or identical substituents independently selected from halogen, cyano, Ci-C6-alkyl, Ci-Ce haloalkyl, Ci-Ce alkoxy, Ci-Ce haloalkoxy, Ci-Ce alkylthio, Ci-Ce haloalkylthio, C3-C8 cycloalkyl, C3-Cs halocycloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl or C2-C6 haloalkynyl;

Ra, Rb, Rc, Rd, R5 and R5a are selected from the group consisting of Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, Ci-Ce alkoxy, Ci-Ce alkylthio, Ci-Ce alkylsulfinyl, or Ci-Ce alkylsulfonyl, wherein one or more CH2 groups may be replaced by a C(=0) group, and optionally substituted with halogen, Ci-Ce alkoxy, phenyl, benzyl, pyridyl or phenoxy, wherein phenyl, benzyl, pyridyl and phenoxy may be optionally substituted with halogen, Ci-Ce alkyl, Ci-Ce haloalkyl, Ci-Ce alkoxy, Ci-Ce haloalkoxy, Ci-Ce alkoxycarbonyl, Ci-Ce alkylamino or di-(Ci-Ce-alkyl)amino; or

Rc and Rd, together with the nitrogen atom to which they are bound may form a 3-, 4-, 5-, 6- or 7-membered saturated, partially unsaturated or unsaturated heterocyclic ring or ring system which may contain one or more ring members selected from N, O, S, SO and SO2, where the heterocyclic ring or ring system optionally may be substituted with halogen, Ci-Ce haloalkyl, Ci-Ce alkoxy or Ci-Ce haloalkoxy;

R14 is hydrogen, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ci-Ce alkylcarbonyl, Ci-C6 alkylaminocarbonyl, Ci-Ce alkoxycarbonyl, each of which is optionally substituted with one or more different or identical group selected from halogen, Ci-Ce alkoxy, Ci-Ce alkylthio, cyano, nitro, formyl, Ci-Ce alkylcarbonyl, Ci-Ce alkoxycarbonyl, Ci-C6 alkylaminocarbonyl, di(Ci-C4alkyl)aminocarbonyl, Ci-Ce alkylsulfinyl, Ci-Ce alkylsulfonyl, C3-C8 cycloalkyl, phenyl or naphthyl, wherein phenyl or naphthyl is optionally substituted with one or more different or identical group selected from halogen, Ci-Ce alkyl, Ci-Ce alkoxy, Ci-Ce haloalkyl, Ci-Ce alkyloxycarbonyl, trifluoromethylsulfonyl, formyl, nitro and cyano; or

R14 is Ci-Ce haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C10 cycloalkenyl, phenyl, naphthyl, 3- to 8- membered ring or ring system which may contain at least one ring member selected from C, N, O, S, SO and SO2; each of which is optionally substituted with one or more different or identical group selected from halogen, Ci-Ce alkyl, Ci-Ce alkoxy, Ci-Ce haloalkyl, Ci-Ce alkyloxycarbonyl, trifluoromethylsulfonyl, formyl, nitro or cyano;

B1 and B2 both are C, or

B1 and B2 together represent a fragment
wherein B1 and B2 in the fragment Ie are independently C or N; provided that both of B1 and B2 simultaneously cannot be N; and A1, A2 and A3 are independently C or N, provided that all of A1, A2 and A3 simultaneously cannot be N;

W1 and W2 are independently O or S;

when B1 and B2 both are C then two R3 together with the carbon atoms to which they are attached may form a 5- to 11- membered carbocyclic, or aryl or heterocyclic or heteroaryl ring or ring system which may be optionally substituted with R2;

each of R2, R2a and R3 are independently selected from hydrogen, halogen, cyano, nitro, hydroxy, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, Ci-Ce haloalkyl, Ci-Ce alkoxyalkyl, Ci-Ce hydroxyalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C6 halocycloalkyl, Ci-Ce alkoxy, Ci-Ce haloalkoxy, Ci-Ce haloalkoxycarbonyl, Ci-Ce alkylthio, Ci-Ce haloalkylthio, Ci-Ce haloalkylsulfinyl, Ci-Ce haloalkylsulfonyl, Ci-Ce alkylsulfinyl, Ci-Ce alkylsulfonyl, Ci-Ce alkylamino, Ci-Ce dialkylamino, C3-C6 cycloalkylamino, Ci-Ce alkyl-C3-C6- cycloalkylamino, Ci-Ce alkylcarbonyl, Ci-Ce alkoxycarbonyl, Ci-Ce alkylaminocarbonyl, Ci-Ce dialkylaminocarbonyl, Ci-Ce alkoxycarbonyloxy, Ci-Ce alkylaminocarbonyloxy, Ci-Ce dialkylaminocarbonyloxy, Ci-Ce trialkylsilyl, Ci-Ce alkoxycarbonylamino, Ci-Ce alkylaminocarbonylamino, Ci-Ce dialkylaminocarbonylamino, Ci-Ce haloalkylcarbonyl or a group RxON=C(Ry)-; wherein Rx and Ry independently are hydrogen or Ci-Ce alkyl; phenyl, benzyl, phenoxy or 4- to 6- membered heterocyclic ring;

each of phenyl, benzyl, phenoxy or 4- to 6- membered heterocyclic ring substituted with one or more different or identical substituents selected from halogen, cyano, nitro, hydroxy, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3- C8 cycloalkyl, C3-C8 cycloalkylalkyl, Ci-Ce haloalkyl, Ci-Ce alkoxyalkyl, Ci- C6 hydroxyalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C6 halocycloalkyl, Ci-Ce alkoxy, Ci-Ce alkylthio, Ci-Ce haloalkylthio, Ci-Ce haloalkylsulfinyl, Ci-Ce haloalkylsulfonyl, Ci-Ce alkylsulfinyl, Ci-Ce alkylsulfonyl, Ci-Ce alkylamino, Ci-Ce dialkylamino, C3-C6 cycloalkylamino, Ci-Ce alkyl-C3-C6- cycloalkylamino, Ci-Ce alkylcarbonyl, Ci-Ce alkoxycarbonyl, Ci-Ce alkylaminocarbonyl, Ci-Ce dialkylaminocarbonyl, Ci-Ce alkoxycarbonyloxy,

Ci-C6 alkylaminocarbonyloxy, C1-C6 dialkylaminocarbonyloxy or C1-C6 tri alkyl sil yl ;

each of R2, R2a and R3 are independently selected from amino, formyl, C2-C6 cyanoalkenyl, C1-C6 alkylcarbonylamino, phenylcarbonylamino, phenyloxycarbonyl, 2-, 3- or 4 pyridylcarbonylamino; each of may be optionally substituted with one or more halogen, cyano, nitro, hydroxy, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, C1-C6 haloalkyl, C1-C6 alkoxyalkyl, C1-C6 hydroxyalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C6 halocycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 haloalkylsulfinyl, C1-C6 haloalkylsulfonyl, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 alkylamino, C1-C6 dialkylamino, C3-C6 cycloalkylamino, C1-C6 alkyl-C3-C6 cycloalkylamino, C1-C6 alkylcarbonyl, C1-C6 alkoxycarbonyl, C1-C6 alkylaminocarbonyl, C1-C6 dialkylaminocarbonyl, C1-C6 alkoxycarbonyloxy, C1-C6 alkylaminocarbonyloxy, C1-C6 dialkylaminocarbonyloxy or Ci-C6trialkylsilyl;

“m” is an integer ranging from 0 to 4;

“n” is an integer ranging from 0 to 3;

R4 is selected from hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, Ci-C6 alkylcarbonyl, C1-C6 alkoxycarbonyl; or each of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C1-C6 alkylcarbonyl, C1-C6 alkoxycarbonyl substituted by one or more different or identical substituents selected from halogen nitro, cyano, hydroxy, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 alkylamino, C1-C6 dialkylamino, C3-C8 cycloalkyl, C3-C6 cycloalkylamino or Ci-C6 alkyl-C3-C6 cycloalkylamino;

D is selected from the group consisting of;

the expression“ ^ “ indicates the point of attachment to either Z1 or to the carbon marked with 2; and

R8 and R9 may be attached to one or more possible position/s,

R8 is selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, C1-C6 haloalkyl, halogen, cyano, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkoxycarbonyl, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfinyl or C1-C6 haloalkylsulfonyl;

R9 is selected from a phenyl ring, a benzyl ring, a 5- or 6-membered heteroaromatic ring, a naphthyl ring system or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system, each ring or ring system optionally substituted with one or more different or identical substituents independently selected from halogen, C1-C6 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, C1-C6 haloalkyl, C2-C4 haloalkenyl, C2-C4 haloalkynyl, C3-C6 halocycloalkyl, cyano, nitro, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkoxycarbonyl, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfinyl, C1-C6 haloalkylsulfonyl, C1-C6 alkylamino, Ci-Cs dialkylamino, Ci-Ce cycloalkylamino, C3-C8 cycloalkyl-Ci-C6-alklyamino, Ci-Ce alkylcarbonyl, Ci-Ce alkoxycarbonyl, Ci-Ce alkylaminocarbonyl, Ci-Cs dialkylaminocarbonyl or Ci-Ce tri alkylsilyl;

Z1 is independently a direct bond or CR6R7 or C(=0) or C(=S) or NRC or O or S(0)o-2;

R6, R7, R6a, R7a, R6b, R7b, R6c, R7c, R6d and R7d are independently selected from hydrogen, halogen, cyano, hydroxy, -CHO, Ci-Ce alkyl, C2-C4 alkenyl, C2-C4 alkynyl, Ci-Ce haloalkyl, C2-C4 haloalkenyl, C2-C4 haloalkynyl, Ci-Ce alkoxyalkyl, Ci-Ce alkylthioalkyl, Ci-Ce alkylsulfinylalkyl, Ci-Ce alkylsulfonylalkyl, Ci-Ce alkylcarbonyl, Ci-Ce haloalkylcarbonyl, C1-C5 alkoxycarbonyl, Ci- C5 alkoxycarbonyl-Ci-C4-alkyl, C1-C5 alkylaminocarbonyl, Ci- C5 dialkylaminocarbonyl, Ci-Ce alkoxy, Ci-Ce haloalkoxy, C3-C8 cycloalkyl, C3- C8 cycloalkylalkyl, Ci-Ce alkylthio, Ci-Ce haloalkylthio, Ci-Ce alkylsulfinyl, Ci-Ce haloalkylsulfinyl, Ci-Ce alkylsulfonyl or Ci-Ce haloalkylsulfonyl;

E is a 4- to 7- membered carbocyclic ring; wherein the ring members of carbocyclic are selected from C, C(=0), C(=S), C(=CR6bR7b), or C(=NR5); or

E is a 3- to 4- membered heterocyclic ring, wherein the heteroatoms are selected from N, O, and S(O)0-2, and C ring member of the heterocyclic may be replaced with C(=0), C(=S), C(=CR6CR7c), C(=NR5), or -S(=0)o-i(=NR5)-; said 3- to 4- membered heterocyclic ring is attached to Z1 through C or N; and

said carbocyclic or said heterocyclic ring is optionally substituted with one or more identical or different R15;

R15 is selected from the group consisting of is hydrogen, halogen, cyano, nitro, hydroxyl, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, Ci-Ce alkoxy, C3-C8 cycloalkoxy, Ci-Ce hydroxyalkyl, Ci-Ce alkylthio, Ci-Ce alkylsulfinyl, Ci-Ce alkylsulfonyl, C3-C8 cycloalkylthio, Ci-Ce alkylamino, Ci-Ce dialkylamino, C3-C8 cycloalkylamino, Ci-Ce haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C8 halocycloalkyl, Ci-Ce haloalkoxy, Ci-Ce haloalkylthio, Ci-Ce haloalkylsulfinyl, Ci-Ce haloalkylsulfonyl, Ci-Ce alkoxy-Ci-C4-alkyl, C3-C8 cycloalkyl-Ci-C6 alkyl, C3-C8 cycloalkyl-Ci-C6-alkyl-amino, Ci-Ce alkylcarbonyl, Ci-Ce alkoxycarbonyl, Ci-Ce alkoxycarbonylamino, Ci-Ce haloalkoxycarbonyl, Ci-Ce alkylaminocarbonyl, Ci-Ce dialkylaminocarbonyl, Ci-Ce alkoxycarbonyloxy, Ci-Ce alkylaminocarbonyloxy, or Ci-Ce dialkylaminocarbonyloxy, Ci-Ce alkoxycarbonylamino; or

two geminal R15 together with the atom to which they are attached may form a substituted or unsubstituted spirocyclic ring or ring system, wherein the ring members of the spirocyclic ring or ring system are selected from C, N, O, and S(0)o-2, and C ring member of the spirocyclic ring or ring system may be replaced with C(=0), C(=S), C(=CR6dR7d), C(=NR5); or

two R15 together with the atoms to which they are attached may form a substituted or unsubstituted carbocyclic or heterocyclic ring or ring system, wherein the ring members of the carbocyclic ring or ring system are selected from C, C(=0), C(=S), C(=CR6dR7d), C(=NR5); and the ring members of the heterocyclic ring or ring system besides C include N, O, and S(0)o-2, and C ring member of the heterocyclic may be replaced with C(=0), C(=S), C(=CR6dR7d), C(=NR5);

wherein, the substituents on the spirocyclic ring or ring system formed by two geminal R15; or the carbocyclic ring or ring system the heterocyclic ring or ring system formed by two R15 are selected from the group consisting of hydrogen, halogen, cyano, nitro, hydroxyl, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, Ci-Ce alkoxy, C3-C8 cycloalkoxy, Ci-Ce hydroxyalkyl, Ci-Ce alkylthio, Ci-Ce alkylsulfinyl, Ci-Ce alkylsulfonyl, C3-C8 cycloalkylthio, Ci-Ce alkylamino, Ci- C6 dialkylamino, C3-C8 cycloalkylamino, Ci-Ce haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C8 halocycloalkyl, Ci-Ce haloalkoxy, Ci-Ce haloalkylthio, Ci-Ce haloalkylsulfinyl, Ci-Ce haloalkylsulfonyl, Ci-Ce alkoxy-Ci-C4-alkyl, C3-C8 cycloalkyl-Ci-C6 alkyl, C3-C8 cycloalkyl-Ci-C6-alkyl-amino, Ci-Ce alkylcarbonyl, Ci- C6 alkoxycarbonyl, Ci-Ce alkoxycarbonylamino, Ci-Ce haloalkoxycarbonyl, Ci-Ce alkylaminocarbonyl, Ci-Ce dialkylaminocarbonyl, Ci-Ce alkoxycarbonyloxy, Ci-Ce alkylaminocarbonyloxy, Ci-Ce dialkylaminocarbonyloxy, or Ci-Ce alkoxycarbonylamino;

or salts, metal complexes, N-oxides, isomers, or polymorphs thereof.

2. The compound according to claim 1,

wherein,

W1 and W2 are O;

“m” is an integer ranging from 0 to 2;

“n” is an integer ranging from 0 to 2;

R4 is hydrogen or Ci-Ce alkyl;

D is;

D4

wherein,

the expression“ ^ “ indicates the point of attachment to either Z1 or to the carbon marked with 2; and

R8 and R9 may be attached to one or more possible position/s,

R8 is selected from hydrogen, C1-C6 alkyl, halogen and cyano;

R9 is selected from 6- membered heteroaromatic ring, substituted with one or more halogen;

Z1 is independently a direct bond or CR6R7 or O or S(0)o-2; and

R6 and R7 are hydrogen;

E is a 3- to 4- membered heterocyclic ring, wherein the heteroatoms are selected from N, O, and S(0)o-2; said 3- to 4- membered heterocyclic ring is attached to Z1 through C or N; said heterocyclic ring is optionally substituted with one or more identical or different R15;

R15 is selected from the group consisting of is halogen, cyano, hydroxyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl and C3-C8 cycloalkylthio.

3. The compound according to claim 1, wherein said compound of formula (I) is selected from N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3- yloxy)-lH-pyrazole-5-carboxamide N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-l-(3- chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2- ((cyclopropylmethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3- yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(cyclopropylcarbamoyl)-6-methylphenyl)- l-(3-chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2- (butylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH- pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-methyl-6- (methylcarbamoyl)phenyl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2- (isopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH- pyrazole-5-carboxamide; N-(4-chloro-2-(ethylcarbamoyl)-6-methylphenyl)-l-(3- chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-(tert- butylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH- pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-(ethylcarbamoyl)-6- methylphenyl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N- (4-cyano-2-((cyclopropylmethyl)carbamoyl)-6-methylphenyl)-3-(oxetan-3-yloxy)-lH- pyrazole-5-carboxamide; N-(2-(butylcarbamoyl)-4-cyano-6-methylphenyl)-l-(3- chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2- yl)-N-(4-cyano-2-(isopropylcarbamoyl)-6-methylphenyl)-3-(oxetan-3-yloxy)-lH-pyrazole-5- carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-(cyclopropylcarbamoyl)-6- methylphenyl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-

(methylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyr azole-5-carboxamide; N-(4-chloro-2-((cyclopropylmethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2- (ethylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole- 5 -carboxamide; N-(4-chloro-2-(isopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(cyclopropylcarbamoyl)- 6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide;

N-(2-(butylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((cyclopropylmethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyri din-2- yl)-3-((l,l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(ethylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l,l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2- (isopropylcarbamoyl)-6-methylphenyl)-l -(3-chloropyridin-2-yl)-3-((l , 1 -dioxidothietan-3 -yl)oxy)-lH-pyrazole-5 -carboxamide; N-(4-chloro-2-(cyclopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyri din-2- yl)-3-((l,l -dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-(butylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l,l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6- (methylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l,l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(methylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(ethylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(cyclopropylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6- ((cyclopropylmethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(isopropylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-6- (butylcarbamoyl)-4-chlorophenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH-pyrazole-5 -carboxamide; N-(2-bromo-6-(tert-butylcarbamoyl)-4-chlorophenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-(tert-butylcarbamoyl)-4-cyano-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamide; 6-(l-(3-chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamido)-N-isopropyl-5-methyl- lH-indazole-7-carboxamide; 6-(l-(3-chloropyridin-2-yl)-3-(oxetan-3-yloxy)-lH-pyrazole-5-carboxamido)-N-ethyl-5-methyl-lH-indazole-7-carboxamide; N-(2-bromo-4-chloro-6-((cyclopropylmethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(cyclopropylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(isopropylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-

pyrazole-5-carboxamide; N-(2-bromo-6-(butylcarbamoyl)-4-chlorophenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-((cyclopropylmethyl)carbamoyl)-6-methylphenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-(cyclopropylcarbamoyl)-6-methylphenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-(isopropylcarbamoyl)-6-methylphenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-(butylcarbamoyl)-4-cyano-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-(tert-butylcarbamoyl)-4-cyano-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-6-(tert-butylcarbamoyl)-4-chlorophenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(methylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(ethylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((cyclopropylmethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((3-(trifluoromethyl)oxetan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(isopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((3-(tri£luoromethyl)oxetan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((3-(tri£luoromethyl)oxetan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((3-(trifluoromethyl)oxetan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(cyclopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((3-(tri£luoromethyl)oxetan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-(allylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((3-(trifluoromethyl)oxetan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(3,3-difluoroazetidine-l-carbonyl)-6-methylphenyl)- 1-(3-chloropyridin-2-yl)-3-((3-(trifluoromethyl)oxetan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((2-cyanoethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin- 2-yl)-3-((3-(trifluoromethyl)oxetan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((2-methoxyethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((3-(tri£luoromethyl)oxetan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((2-(methylthio)ethyl)carbamoyl)phenyl)-l-(3-chloropyri din-2- yl)-3-((3-(tri£luoromethyl)oxet an- 3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-methyl-6- (methylcarbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-(ethylcarbamoyl)-6-methylphenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(methylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((3-(trifluoromethyl)oxetan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(cyclopropylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((3-(tri£luoromethyl)oxetan-3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N- (4-cyano-2-methyl-6-(methylcarbamoyl)phenyl)-3-((3-(trifluoromethyl)oxetan-3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-(cyclopropylcarbamoyl)-6-methylphenyl)-3-((3-(trifluoromethyl)oxetan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylthio)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(cyclopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylthio)-lH-pyrazole-5-carboxamide; N-(4-chloro-2- ((cyclopropylmethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylthio)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(isopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylthio)-lH-pyrazole-5-carboxamide; N-(4-chloro-2- (ethylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylthio)-lH-pyrazole- 5 -carboxamide; rac-(R)-l-(3-chloropyridin-2-yl)-N-(4-cyano-2-methyl-6-((2-methyl-3-oxoisoxazolidin-4-yl)carbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((2-(methylthio)ethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylthio)-lH-pyrazole-5-carboxamide; N-(2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylthio)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((2-methoxyethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylthio)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6- (propylcarbamoyl)phenyl)-l-(3-chloropyri din-2- yl)-3-(oxetan-3-ylthio)-lH-pyrazole-5-carboxamide; N-(2-(allylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylthio)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(prop-2-yn-l-ylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylthio)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(3,3-difluoroazetidine- 1-carbon yl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylthio)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl- 6-(oxetan-3-ylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylthio)-lH-pyrazole- 5 -carboxamide; 6-(l-(3 -chloropyridin-2-yl)-3-(3 ,3 -difluoroazetidin- 1 -yl)-l H-pyrazole-5-carboxamido)-N-(cyclopropylmethyl)-5-methylpyrazolo[l,5-a]pyridine-7-carboxamide; 6-(l-(3-chloropyridin-2-yl)-3-(3,3-difluoroazetidin-l-yl)-lH-pyrazole-5-carboxamido)-N,5-dimethylpyrazolo[l,5-a]pyridine-7-carboxamide; 6-(l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamido)-N-(cyclopropylmethyl)-5-methylpyrazolo[l,5-a]pyridine-7-carboxamide; N-(tert-butyl)-6-(l-(3-chloropyridin-2-yl)-3-(3,3-difluoroazetidin-l-yl)-lH-pyrazole-5-carboxamido)-5-methylpyrazolo[l,5-a]pyridine-7-carboxamide; 6-(l-(3-chloropyridin-2-yl)-3-(3,3-difluoroazetidin-l-yl)-lH-pyrazole-5-carboxamido)-N-isopropyl-5-methylpyrazolo[l,5-a]pyridine-7-carboxamide; 6-(l-(3-chloropyridin-2-yl)-3-(3,3-difluoroazetidin-l-yl)-lH-pyrazole-5-carboxamido)-N-(diethyl-14-sulfaneylidene)-5-methylpyrazolo[l,5-a]pyridine-7-carboxamide; 6-(l-(3-chloropyridin-2-yl)-3-(3,3-difluoroazetidin- 1 -yl)- lH-pyrazole-5-carboxamido)-N-ethyl-5-methylpyrazolo[ 1 ,5 -a]pyridine-7-carboxamide; 6-(l-(3-chloropyridin-2-yl)-3-(3,3-di£luoroazetidin-l-yl)-lH-

pyrazole-5-carboxamido)-N-methoxy-5-methylpyrazolo[l,5-a]pyridine-7-carboxamide; 6-(l-(3-chloropyridin-2-yl)-3-(3,3-difluoroazetidin-l-yl)-lH-pyrazole-5-carboxamido)-N-cyclopropyl-5-methylpyrazolo[l,5-a]pyridine-7-carboxamide; N-allyl-6-(l-(3-chloropyridin-2-yl)-3-(3,3-difluoroazetidin-l-yl)-lH-pyrazole-5-carboxamido)-5-methylpyrazolo[l,5-a]pyridine-7-carboxamide; N-(2-bromo-4-chloro-6-((cyanomethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(3,3-difluoroazetidine-l-carbonyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-(azetidine-l-carbonyl)-6-bromo-4-chlorophenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(methoxycarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-(allylcarbamoyl)-6-bromo-4-chlorophenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((2- (methylthio)ethyl)carbamoyl)phenyl)-l-(3-chloropyri din-2- yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((2-methoxyethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(prop-2-yn-l-ylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5 -carboxamide; N-(2-bromo-4-chloro-6-((2-cyanoethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-(allylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l,l-dioxidothietan-3-yl)oxy)- 1 H-pyrazole-5 -carboxamide; N-(4-chloro-2-methyl-6-(propylcarbamoyl)phenyl)- 1 -(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((2-methoxyethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((diethyl-14-sulfaneylidene)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; tert-butyl 3-((5-((4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)carbamoyl)-l-(3-chloropyridin- 2-yl)-lH-pyrazol-3-yl)oxy)azetidine-l-carboxylate; tert-butyl 3-((5-((4-chloro-2- (isopropylcarbamoyl)-6-methylphenyl)carbamoyl)- 1-(3 -chloropyridin-2-yl)- lH-pyrazol-3-yl)oxy)azetidine-l-carboxylate; tert-butyl 3-((5-((2-(tert-butylcarbamoyl)-4-cyano-6-methylphenyl)carbamoyl)-l-(3-chloropyridin-2-yl)-lH-pyrazol-3-yl)oxy)azetidine-l-carboxylate; 6-(l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamido)-N,5-dimethylpyrazolo[l,5-a]pyridine-7-carboxamide; tert-butyl 3-((5-((2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl)carbamoyl)-l-(3-chloropyridin-2-yl)-lH-pyrazol- 3-yl)oxy)azetidine-l-carboxylate; 6-(l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamido)-5-methyl-N-propylpyrazolo[l,5-a]pyridine-7-carboxamide; l-(3- chloropyridin-2-yl)-N-(4-cyano-2-methyl-6-(propylcarbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((cyanomethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(methylcarbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(ethylcarbamoyl)phenyl)-3-(thietan-3 -yloxy)-lH-pyrazole-5 -carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6- (isopropylcarbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(cyclopropylcarbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6- ((cyclopropylmethyl)carbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; 1-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(propylcarbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(isopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-((2-methoxyethyl)carbamoyl)-6-methylphenyl)-3-(thietan-3 -yloxy)-lH-pyrazole-5 -carboxamide; N-(4-chloro-2-((l-cyclopropylethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(methoxycarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((2,2,2-trifluoroethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5 -carboxamide; N-(4-chloro-2-(ethoxycarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(isopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyri din-2- yl)-3-(oxetan-3-ylmethyl)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-(2,2,2-trifluoroethyl)azetidin-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2- (isopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l -(2,2,2-trifluoroethyl)azetidin-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6- (methylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(ethylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(cyclopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5 -carboxamide; N-(4-chloro-2-((cyclopropylmethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyri din-2- yl)-3-((l-oxidothietan-3-yl)oxy)- lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(propylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(methoxycarbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; 1-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-((2,2,2-trifluoroethyl)carbamoyl)phenyl)-3-(thietan-3 -yloxy)-lH-pyrazole-5 -carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-((2-

methoxyethyl)carbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-(methoxycarbamoyl)-6-methylphenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-methyl-6-(oxetan-3-ylcarbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-((cyanomethyl)carbamoyl)-6-methylphenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; 6-(l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamido)-N-ethyl-5-methylpyrazolo[l,5-a]pyridine-7-carboxamide; 6-(l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamido)-N-cyclopropyl-5-methylpyrazolo[l,5-a]pyridine-7-carboxamide; 6-(l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamido)-N-(l-cyclopropylethyl)-5-methylpyrazolo[l,5-a]pyridine-7-carboxamide; 6-(l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamido)-N-methoxy-5-methylpyrazolo[l,5-a]pyridine-7-carboxamide; N-(2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5 -carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-((2,2,2-trifluoroethyl)carbamoyl)phenyl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-((cyclopropylmethyl)carbamoyl)phenyl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(ethylcarbamoyl)phenyl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l-(2,2,2-trifluoroethyl)azetidin-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(ethylcarbamoyl)-6-methylphenyl)-l -(3-chloropyridin-2-yl)-3 -((1 -(2,2,2-trifluoroethyl)azetidin-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2- (isopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l -(2,2,2-trifluoroacetyl)azetidin-3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(methylcarbamoyl)phenyl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(propylcarbamoyl)phenyl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(isopropylcarbamoyl)phenyl)-3 -(( 1 -oxidothietan-3 -yl)oxy)- 1 H-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(cyclopropylcarbamoyl)phenyl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(prop-2-yn-l-ylcarbamoyl)phenyl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(methoxycarbamoyl)phenyl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-((2-methoxyethyl)carbamoyl)phenyl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-((l-cyclopropylethyl)carbamoyl)phenyl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; 6-(l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamido)- N-(2-methoxyethyl)-5-methylpyrazolo[l,5-a]pyridine-7-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(ethoxycarbamoyl)phenyl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5 -carboxamide; N-(2-(tert-butylcarbamoyl)-4,6-dichlorophenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; tert -butyl 3-((l -(3-chloropyridin-2-yl)-5-((4-cyano-2-methyl-6-(methylcarbamoyl)phenyl)carbamoyl)-lH-pyrazol-3-yl)oxy)azetidine-l-carboxylate; tert-butyl 3-((l-(3-chloropyridin-2-yl)-5-((4-cyano-2-(isopropylcarbamoyl)-6-methylphenyl)carbamoyl)-lH-pyrazol-3-yl)oxy)azetidine-l-carboxylate; tert-butyl 3-((l-(3-chloropyridin-2-yl)-5-((4-cyano-2-(cyclopropylcarbamoyl)-6-methylphenyl)carbamoyl)-lH-pyrazol-3-yl)oxy)azetidine-l-carboxylate; tert-butyl 3-((l-(3-chloropyridin-2-yl)-5-((4-cyano-2-((l-cyclopropylethyl)carbamoyl)-6-methylphenyl)carbamoyl)-lH-pyrazol-3-yl)oxy)azetidine-l-carboxylate; tert-butyl 3-((l-(3-chloropyridin-2-yl)-5-((4-cyano-2-(methoxycarbamoyl)-6-methylphenyl)carbamoyl)-lH-pyrazol-3-yl)oxy)azetidine-l-carboxylate; tert-butyl 3-((l-(3-chloropyridin-2-yl)-5-((4-cyano-2-methyl-6-((2,2,2-trifluoroethyl)carbamoyl)phenyl)carbamoyl)-lH-pyrazol-3-yl)oxy)azetidine-l-carboxylate; N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylmethyl)-lH-pyrazole -5-carboxamide; N-(2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylmethyl)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(propylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylmethyl)-lH-pyrazole -5-carboxamide; N-(4-chloro-2-(ethylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylmethyl)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(cyclopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylmethyl)-lH-pyrazole -5-carboxamide; N-(4-chloro-2-((cyclopropylmethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylmethyl)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((l-cyclopropylethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyri din-2- yl)-3-(oxetan-3-ylmethyl)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(methoxycarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(oxetan-3-ylmethyl)- lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6- (isopropylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((2-methoxyethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(cyclopropylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5 -carboxamide; N-(2-(tert-butylcarbamoyl)-4,6-dichlorophenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; tert-butyl 3-((l-(3-chloropyridin-2-yl)-5-((2,4-dichloro-6-(methylcarbamoyl)phenyl)carbamoyl)-lH-pyrazol-3-yl)oxy)azetidine-l-carboxylate; tert-butyl 3-((l-(3-chloropyridin-2-yl)-5-((2,4-dichloro-6-(isopropylcarbamoyl)phenyl)carbamoyl)- 1 H-pyrazol-3-yl)oxy)azetidine- 1 -carboxylate; tert-butyl 3-((l-(3-chloropyridin-2-yl)-5-((2,4-dichloro-6-

(cyclopropylcarbamoyl)phenyl)carbamoyl)-lH-pyrazol-3-yl)oxy)azetidine-l-carboxylate; tert-butyl 3-((5-((2-(tert-butylcarbamoyl)-4,6-dichlorophenyl)carbamoyl)-l-(3-chloropyridin- 2-yl)-lH-pyrazol-3-yl)oxy)azetidine-l-carboxylate; tert-butyl 3-((l-(3-chloropyridin-2-yl)-5- ((2,4-dichloro-6-(methoxycarbamoyl)phenyl)carbamoyl)-lH-pyrazol-3-yl)oxy)azetidine-l-carboxylate; tert-butyl 3-((l-(3-chloropyridin-2-yl)-5-((2,4-dichloro-6-((l-cyclopropylethyl)carbamoyl)phenyl)carbamoyl)-lH-pyrazol-3-yl)oxy)azetidine-l-carboxylate; tert-butyl 3-((l-(3-chloropyridin-2-yl)-5-((2,4-dichloro-6-((2,2,2-trifluoroethyl)carbamoyl)phenyl)carbamoyl)-lH-pyrazol-3-yl)oxy)azetidine-l -carboxylate; N-(2-bromo-4-chloro-6-(propylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6- ((cyclopropylmethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5 -carboxamide; N-(2-bromo-6-(tert-butylcarbamoyl)-4-chlorophenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((2,2,2-tri£luoroethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((2,2,2-trifluoroethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole- 5 -carboxamide; N-(2-bromo-6-(tert-butylcarbamoyl)-4-chlorophenyl)-l-(3-chloropyridin-2-yl)-3-((l, l-dioxidothietan-3-yl)oxy)- lH-pyrazole-5 -carboxamide; N-(4-chloro-2-methyl-6-((2,2,2-tri£luoroethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)- lH-pyrazole-5 -carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-methyl-6- ((2,2,2-trifluoroethyl)carbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; 1-(3-chloropyridin-2-yl)-N-(4-cyano-2-methyl-6-((2,2,2-trifluoroethyl)carbamoyl)phenyl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-(tert-butylcarbamoyl)-4-cyano- 6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l,l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-(tert-butylcarbamoyl)-4-cyano-6-methylphenyl)-l-(3-chloropyridin-2-yl)- 3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((l-methylcyclopropyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((3-methyloxetan-3-yl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-(((3s,5s,7s)-adamantan-l-yl)carbamoyl)-6-bromo-4-chlorophenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((l-methoxy-2-methylpropan-2-yl)carbamoyl)phenyl)- 1 -(3-chloropyridin-2-yl)-3 -(thietan-3 -yloxy)- lH-pyrazole-5 -carboxamide; N-(2-bromo-4-chloro-6-(ethylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6- (methylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((l-hydroxy-2-methylpropan-2-yl)carbamoyl)phenyl)- 1 -(3-chloropyridin-2-yl)-3 -(thietan-3 -yloxy)- lH-pyrazole-5-

carboxamide; N-(2-bromo-4-chloro-6-((l-cyanocyclopropyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-methyl-6-((2,2,2-trifluoroethyl)carbamoyl)phenyl)-3-((l,l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(isobutylcarbamoyl)phenyl)- 1-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((2,2,2-trifluoroethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l,l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((2,2,2-trifluoroethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l,l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(thietan-3-ylcarbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2- (methoxycarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l,l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5 -carboxamide; N-(2-(((3s,5s,7s)-adamantan-l-yl)carbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-(((lr,3r,5r,7r)-adamantan-2-yl)carbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l, l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((l-hydroxy-2-methylpropan-2-yl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin- 2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((l-methylcyclopropyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((l-methylcyclopropyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l,l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((3,3-dimethylbutyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((l, l,l-trifluoropropan-2-yl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(neopentylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((3,3-dimethylbutan-2-yl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((2-methylbutyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(pentan-2-ylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((2,2-difluoroethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-((l-hydroxy-2-methylpropan-2-yl)carbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-(((3R,5S)-adamantan-l-yl)carbamoyl)-4,6-dichlorophenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; 1-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-((l-methoxy-2-methylpropan-2-yl)carbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-((3-methyloxetan-3-yl)carbamoyl)phenyl)-3-(thietan-3-yloxy)-lH- pyrazole-5-carboxamide; N-(2-(tert-butylcarbamoyl)-4,6-dichlorophenyl)-l-(3-chloropyridin- 2-yl)-3-((l, l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(thietan-3-ylcarbamoyl)phenyl)- l-(3 -chi oropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyr azole-5-carboxamide; N-(4-chloro-2-(methoxycarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)- 3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((l-hydroxy-2-methylpropan-2-yl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((l-methylcyclopropyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(pentan-3-ylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(pentan-3-ylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(pentan-3-ylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l, l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((3,3-dimethylbutyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((3,3-dimethylbutyl)carbamoyl)-6-methylphen yl)-l-(3-chlorop yri din-2- yl)-3-((l -oxidothietan-3-yl)oxy)- 1 H-pyrazole-5 -carboxamide; N-(2-bromo-4-chloro-6-(isopentylcarbamoyl)phenyl)- 1 -(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((3,3-dimethylbutyl)carbamoyl)-6-methylphenyl)-l-(3-chlorop yri din-2- yl)-3-((l, l -dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((l-methoxybutan-2-yl)carbamoyl)phenyl)- 1 -(3-chloropyridin-2-yl)-3 -(thietan-3 -yloxy)- lH-pyrazole-5 -carboxamide; N-(2-bromo-4-chloro-6-(((tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((2,2-difluoroethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((2,2-difluoroethyl)carbamoyl)-6-methylphenyl)- 1 -(3-chloropyridin-2-yl)-3 -(( 1 -oxidothietan-3 -yl)oxy)- lH-pyrazole-5 -carboxamide; N-(4-chloro-2-((2,2-di£luoroethyl)carbamoyl)-6-methylphenyl)-l-(3-chlorop yri din-2- yl)-3-((l, l -dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(neopentylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6- (neopentylcarbamoyl)phenyl)- l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(neopentylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l, l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((3,3-dimethylbutan-2-yl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((3,3-dimethylbutan-2-yl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((3,3-dimethylbutan-2-yl)carbamoyl)-6-

methylphenyl)-l-(3-chloropyri din-2- yl)-3-((l,l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((2-methylbutyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((2-methylbutyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((2-methylbutyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l, l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(pentan-2-ylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(pentan-2-ylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(pentan-2-ylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l, l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(pentan-3-ylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyr azole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(pentan-3-ylcarbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-((2-methylbutyl)carbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-(pentan-2-ylcarbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(2,4-dichloro-6-((3,3-dimethylbutyl)carbamoyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((5-methylhexan-2-yl)carbamoyl)phenyl)-l-(3-chloropyri din-2- yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-(((lr,3r,5r,7r)-adamantan-2-yl)carbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5 -carboxamide; N-(4-chloro-2-methyl-6-((3-methylbutan-2-yl)carbamoyl)phenyl)- 1 -(3-chloropyridin-2-yl)-3 -(thietan-3 -yloxy)- lH-pyrazole-5 -carboxamide; N-(4-chloro-2-methyl-6-((3-methylbutan-2-yl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((3-methylbutan-2-yl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l,l-dioxidothietan-3-yl)oxy)- lH-pyrazole-5-carboxamide; N-(4-chloro-2-((l -methoxybutan-2-yl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((l-methoxybutan-2-yl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-((l-methoxybutan-2-yl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-((l,l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(isopentylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; (S)-N-(4-chloro-2-methyl-6-(((tetrahydrofuran-2-yl)methyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2- ((cyclopentylmethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyri din-2- yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(((tetrahydro-2H-pyran-2-

yl)methyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(((tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((thiazol-2-ylmethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((2-(4-methylthiazol-5-yl)ethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((5-methylhexan-2-yl)carbamoyl)phenyl)- 1 -(3-chloropyridin-2-yl)-3 -(thietan-3 -yloxy)- lH-pyrazole-5 -carboxamide; N-(4-chloro-2-methyl-6-((5-methylhexan-2-yl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((3-methylbutan-2-yl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)- lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6- ((cyclopentylmethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(((tetrahydro-2H-pyran-2-yl)methyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((2-(5-methylthiazol-4-yl)ethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2- (isopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-ylmethyl)-lH-pyrazole-5-carboxamide; N-(2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-ylmethyl)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((5-methylhexan-2-yl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-((l,l-dioxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-((l, l,l-trifluoropropan-2-yl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; (S)-N-(2-bromo-4-chloro-6-(((tetrahydrofuran-2-yl)methyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((thiazol-2-ylmethyl)carbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-methyl-6-(methylcarbamoyl)phenyl)-3-(thietan-3-ylmethyl)- lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-(isopropylcarbamoyl)-6-methylphenyl)-3-(thietan-3-ylmethyl)-lH-pyrazole-5-carboxamide; N-(2-(tert-butylcarbamoyl)-4-cyano-6-methylphenyl)-l-(3-chloropyri din-2- yl)-3-(thietan-3-ylmethyl)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-(cyclopropylcarbamoyl)-6-methylphenyl)-3-(thietan-3-ylmethyl)-lH-pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2- ((cyclopropylmethyl)carbamoyl)-6-methylphenyl)-3-(thietan-3-ylmethyl)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-ylmethyl)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(cyclopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyri din-2- yl)-3-(thietan-3-ylmethyl)-lH-pyrazole-5-carboxamide;

N-(4-chloro-2-((cyclopropylmethyl)carbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3- (thietan-3-ylmethyl)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(methoxycarbamoyl)-6- methylphenyl)-l-(3-chloropyri din-2- yl)-3-(thietan-3-ylmethyl)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-((l-hydroxy-2-methylpropan-2-yl)carbamoyl)phenyl)-l-(3- chloropyridin-2-yl)-3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(2-bromo-4- chloro-6-(thietan-3-ylcarbamoyl)phenyl)-l-(3-chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH- pyrazole-5-carboxamide; l-(3-chloropyridin-2-yl)-N-(4-cyano-2-methyl-6-((l, 1,1- trifluoropropan-2-yl)carbanioyl)phenyl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N- (4-chloro-2-(3-methoxy-3-(trifluoromethyl)azetidine-l-carbonyl)-6-methylphenyl)-l-(3- chloropyridin-2-yl)-3-(thietan-3-yloxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2-(3- methoxy-3-(trifluoromethyl)azetidine- 1-carbon yl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)- 3-((l-oxidothietan-3-yl)oxy)-lH-pyrazole-5-carboxamide; N-(4-chloro-2- (isopropylcarbamoyl)-6-methylphenyl)-l-(3-chloropyridin-2-yl)-3-(3,3-difluoroazetidin-l- yl)-lH-pyrazole-5-carboxamide; N-(2-bromo-4-chloro-6-(isopropylcarbamoyl)phenyl)-l-(3- chloropyridin-2-yl)-3-(3,3-difluoroazetidin-l-yl)-lH-pyrazole-5-carboxamide and l-(3- chloropyridin-2-yl)-N-(4-cyano-2-(isopropylcarbamoyl)-6-methylphenyl)-3-(3,3- difluoroazetidin-l-yl)-lH-pyrazole-5-carboxamide.

4. A composition for controlling or preventing insects and/or mite pests comprising a biologically effective amount of compound of formula (I) or salts, metal complexes, N- oxides, isomers, or polymorphs thereof according to claim 1 and at least one additional component selected from the group consisting of surfactants and auxiliaries.

5. The composition according to claim 4, wherein said composition is used for agricultural, horticultural, veterinary, household and vector control applications.

6. The composition according to claim 4, wherein said composition additionally comprises at least one additional biological active compatible compound selected from fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, plant growth regulators, antibiotics, fertilizers or nutrients.

7. The composition according to claim 4, wherein said biologically effective amount of compound of formula (I) ranges from 0.1 % to 99% by weight with respect to the total weight of the composition, preferably ranges from 5 to 50% by weight with respect to the total weight of the composition.

8. A combination comprising a biologically effective amount of the compound according to claim 1 and at least one additional biological active compatible compound selected from fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, plant growth regulators, antibiotics, fertilizers and nutrients.

9. A method of combating insects and mite pests comprising contacting the insects and mite pests, their habit, breeding ground, food supply, plant, seed, soil, area, material or environment in which the insect and mite pests are growing or may grow, or the materials, plants, seeds, soils, surfaces or spaces to be protected from pest attack or infestation with a biologically effective amount of compound of formula (I) or salts, metal complexes, N- oxides, isomers, polymorphs, composition or combination thereof according to claim 1 or 4 or

7.

10. A method for protecting crops from attack or infestation by insects and mite pests comprises contacting the crop with a biologically effective amount of the compound or salts, metal complexes, N-oxides, isomers, polymorphs, composition or combination thereof according to claim 1 or 4 or 7.

11. The method according to claim 10, wherein said method comprises applying effective dosages of compound of formula (I) in amounts ranging from 1 gai to 5000 gai per hectare in agricultural or horticultural crops.

12. A method for the protection of seeds, plants and plant parts from soil insects and of the seedlings roots and shoots from soil and foliar insects comprising contacting the seeds before sowing and/or after pre- germination with the compound of formula (I) or salts, metal complexes, N-oxides, isomers, polymorphs, composition or combination thereof according to claim 1 or 4 or 7.

13. A method for treating or protecting animals against infestation or infection by parasites which comprises orally, topically or parenterally administering or applying to the animals a biologically effective amount of the compound of formula (I) or salts, metal complexes, N- oxides, isomers, polymorphs, composition or combination thereof according to claim 1 or 4 or

7.

14. Use of the compound of formula (I) or salts, metal complexes, N-oxides, isomers, polymorphs, composition or combination thereof according to claim 1 or 4 or 7, for combating insects and mite pests in agricultural crops, horticultural crops, household and vector control and parasites on animals.

15. The use of the compound of formula (I) according 14, for the preparation of a medicament for treating or protecting animals against infestation or infection by insect and mite pests or parasites.

16. The use of the compound of formula (I) according 14, wherein said agricultural crops are cereals, corn, sorghum, bajra, rice, soybean, oil seeds and other leguminous plants, fruits and fruit trees, grapes, nuts and nut trees, citrus and citrus trees, any horticultural plants, cucurbitaceae, oleaginous plants, tobacco, coffee, tea, cacao, sugar beet, sugar cane, cotton, potato, tomato, onions, peppers, other vegetables and ornamentals.

17. A seed comprising a compound of formula (I) or salts, metal complexes, N-oxides, isomers, polymorphs, composition or combination thereof according to claim 1 or 4 or 7, wherein the

amount of compound of formula (I) in said seed ranging from about 0.0001% to about 1% by weight.

18. A process for preparing compound of formula (I) according to claim 1, said process

comprising the steps of:

a. reacting a substituted tetrahydro-pyrazolone (II) with an halogenating reagent to obtain an halogenated dihydro pyrazole (III);

b. reacting the halogenated dihydro pyrazole (III) with an 4- to 7- membered carbocyclic or 3- to 4- membered heterocyclic compound (IV) to obtain a compound of formula (V);

c. aromatizing the compound of formula (V) using acid/base to obtain a compound of formula (lb), wherein R18= -OCi-Ce alkyl;

d. hydrolyzing the compound of formula (lb), wherein R18= -OC1-C6 alkyl, to obtain a compound of formula (lb), wherein R18= OH or X;

e. reacting the compound of formula (lb), wherein R18 = OH or X with anthranilic acid of formula VI to obtain a compound of formula Ic; and

f. reacting the compound of formula Ic with an amine to obtain the compound of formula I.

19. A compounds of formulae la, lb and Ic;

wherein, R17 and R18 are OH, or halo or -0(Ci-C6 alkyl); W1, B1, B2, W2, D, Z1, E, R3, R4, and m are as defined in claim 1.

page 1 of 4 INTERNATIONAL SEARCH REPORT International application No

WO 2019/150220 PCT/ I PCT/IB2019/050470

C(Continuation). DOCUMENTS CONSIDERED TO BE RELEVANT

Form PCT/ISA/210 (continuation of second sheet) (April 2005)

page 2 of 4

INTERNATIONAL SEARCH REPORT International application No

WO 2019/150220 PCT/ I PCT/IB2019/050470

C(Continuation). DOCUMENTS CONSIDERED TO BE RELEVANT

Form PCT/ISA/210 (continuation of second sheet) (April 2005)

page 3 of 4

INTERNATIONAL SEARCH REPORT International application No

WO 2019/150220 PCT/ I PCT/IB2019/050470

Form PCT/ISA/210 (continuation of second sheet) (April 2005)

page 4 of 4