We Claim:
1. Crystalline form-M of N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide diphosphate compound of formula-1 characterized by its X-ray powder diffractogram having peaks at 4.9, 10.0, 12.7, 13.7, 15.1, 16.1, 17.3, 17.9, 18.7, 20.3, 21.8, 24.0 and 26.3 ± 0.2 degrees two-theta as illustrated in figure-1.
2. N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide monophosphate.
3. Crystalline form-S of N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide monophosphate compound of formula-2 characterized by its X-ray powder diffractogram having peaks at 5.0, 9.7, 10.1, 11.8, 12.6, 14.7, 15.4, 16.0, 16.4, 17.2, 18.4, 18.9, 19.3, 19.6, 20.3, 21.2, 21.8, 22.4, 24.2, 25.0, 25.6, 26.3, 26.5 and 29.6 ± 0.2 degrees two-theta as illustrated in figure-2.
4. A process for the preparation of crystalline form-M of N-[6-(cis-2,6-dimethyl morpholin-4-yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide diphosphate compound of formula-1, comprising of the following steps:
a. Adding suitable solvent to N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-
methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide,
b. heating the reaction mixture to suitable temperature,
c. adding phosphoric acid to the reaction mixture,
d. stirring the reaction mixture,
e. cooling the reaction mixture to suitable temperature,
f. stirring the reaction mixture and filtering the precipitated solid to get crystalline
form-M of N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4’-
(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide diphosphate compound of
formula-1.

Wherein, in step-a) the suitable solvent is selected from alcohol solvents, ketone solvents, ester solvents, chloro solvents, ether solvents, nitrile solvents, polar aprotic solvents, hydrocarbon solvents and polar solvents like water or mixture thereof;
in step-b) the suitable temperature is ranging from 25°C to the reflux temperature of solvent used in the reaction;
in step-c) the amount of phosphoric acid is about 2.0 to 3.0 per mole of N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide; in step-e) the temperature is ranging from 0°C to 10°C.
A process for the preparation of crystalline form-M of N-[6-(cis-2,6-dimethylmorpholin-
4-yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide
diphosphate compound of formula-1, comprising of the following steps:
a. Adding methanol to N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-
4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide,
b. heating the reaction mixture to 40-45°C,
c. adding phosphoric acid to the reaction mixture,
d. stirring the reaction mixture,
e. cooling the reaction mixture to 0-5°C,
f. stirring the reaction mixture and filtering the precipitated solid to get crystalline form-
M of N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4’-(trifluoro
methoxy) [1,1’-biphenyl]-3-carboxamide diphosphate compound of formula-1.
A process for the preparation of crystalline form-S of N-[6-(cis-2,6-dimethylmorpholin-4-
yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide
monophosphate compound of formula-2, comprising of the following steps:
a. Adding a suitable solvent to N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-
methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide,
b. heating the reaction mixture to a suitable temperature and stirring the reaction mixture,
c. optionally, filtering the reaction mixture through hyflow bed,
d. adding phosphoric acid to the filtrate obtained in step-c),

e. cooling the reaction mixture to a suitable temperature,
f. stirring the reaction mixture and filtering the precipitated solid to get crystalline form¬
S of N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4’-(trifluoro
methoxy) [1,1’-biphenyl]-3-carboxamide monophosphate compound of formula-2.
Wherein, in step-a) the suitable solvent is selected from alcohol solvents; ketone solvents; ester solvents, chloro solvents, ether solvents, polar aprotic solvents, nitrile solvents and polar solvents like water or mixture thereof;
in step-b) the suitable temperature is ranging from 25°C to the reflux temperature of solvent used in the reaction;
in step-d) the amount of phosphoric acid is about 1.2 to 1.6 per mole of N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide; in step-f) the temperature is ranging from 0°C to 25°C.
. A process for the preparation of crystalline form-S of N-[6-(cis-2,6-dimethylmorpholin-4-
yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide
monophosphate compound of formula-2, comprising of the following steps:
a. Adding acetonitrile to N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-
4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide,
b. heating the reaction mixture to 55-60°C and stirring the reaction mixture,
c. filtering the reaction mixture through hyflow bed,
d. adding phosphoric acid to the filtrate obtained in step-c),
e. cooling the reaction mixture to 0-5°C,
f. stirring the reaction mixture and filtering the precipitated solid to get crystalline form¬
S of N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4’-(trifluoro
methoxy) [1,1’-biphenyl]-3-carboxamide monophosphate compound of formula-2.
. A process for the preparation of crystalline form-S of N-[6-(cis-2,6-dimethylmorpholin-4-
yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide
monophosphate compound of formula-2, comprising of the following steps:

a. Adding a mixture of isopropanol and methanol to N-[6-(cis-2,6-dimethylmorpholin-4-
yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide,
b. heating the reaction mixture to 55-60°C and stirring the reaction mixture,
c. adding phosphoric acid to the reaction mixture,
d. cooling the reaction mixture to 0-5°C,
e. stirring the reaction mixture and filtering the precipitated solid to get crystalline form¬
S of N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4’-(trifluoro
methoxy) [1,1’-biphenyl]-3-carboxamide monophosphate compound of formula-2.
9. A process for the preparation of crystalline form-S of N-[6-(cis-2,6-dimethylmorpholin-4-
yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide
monophosphate compound of formula-2, comprising of the following steps:
a. Adding a suitable solvent to N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-
methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide diphosphate,
b. heating the reaction mixture to a suitable temperature and stirring the reaction mixture,
c. cooling the reaction mixture to a suitable temperature,
d. filtering the precipitated solid to get crystalline form-S of N-[6-(cis-2,6-dimethyl
morpholin-4-yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-
carboxamide monophosphate compound of formula-2.
Wherein, in step-a) the suitable solvent is selected from alcohol solvents;
in step-b) the suitable temperature is ranging from 25°C to the reflux temperature of
solvent used in the reaction;
in step-d) the temperature is ranging from 25-30°C.
10. A process for the preparation of crystalline form-S of N-[6-(cis-2,6-dimethylmorpholin-4-
yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide
monophosphate compound of formula-2, comprising of the following steps:
a. Adding methanol to N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-
4’-(trifluoromethoxy) [1,1’-biphenyl]-3-carboxamide diphosphate,
b. heating the reaction mixture to 55-60°C and stirring the reaction mixture,
c. cooling the reaction mixture to 25-30°C,

d. filtering the precipitated solid to get crystalline form-S of N-[6-(cis-2,6-dimethyl
morpholin-4-yl)pyridine-3-yl]-2-methyl-4’-(trifluoromethoxy) [1,1’-biphenyl]-3-
carboxamide monophosphate compound of formula-2.