Sign In to Follow Application
View All Documents & Correspondence

Novel Formulations Of Vasopressin

Abstract: The present invention relates to novel parenteral formulations of vasopressin, comprising of vasopressin, stabilizers, solvent and other pharmaceutically acceptable excipients.

Get Free WhatsApp Updates!
Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
22 December 2017
Publication Number
26/2019
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2022-08-30
Renewal Date

Applicants

LEIUTIS PHARMACEUTICALS PVT LTD
Plot No 23, V S R Complex, TIE 1st Phase, Balanagar, Hyderabad

Inventors

1. KOCHERLAKOTA CHANDRASHEKHAR
Plot-13, Sonali Cooperative Housing Society,Bhavana Enclave, Bowenpally, Tarbund, Secunderabad-500009
2. BANDA NAGARAJU
Flat 301, Kamalakar Rao Classic, Sapthagiri Colony, Kukatpally, Hyderbad-500072

Specification

1. A parenteral formulation of vasopressin comprising:
a) vasopressin
b) stabilizer comprising
(i) one or more buffers and
(ii) one or more excipients selected from amino acids or chelating agents and
c) one or more additional excipients
wherein the formulation is free of acetate buffer
2. The formulation of claim 1, wherein the amino acid is selected from the group comprising of aspartic acid, isoleucine, arginine and combinations thereof.
3. The formulation of claim 1, wherein the buffers are selected from the group comprising of tris, phosphate buffer, citrate buffer, sodium carbonate, sodium bicarbonate, tartarate, benzoate, aspartic acid, ascorbic acid, succinic acid, lactic acid, glutaric acid, malic acid, boric acid, orthophosphoric acid and carbonic acid and combinations thereof.
4. The formulation of claim 1, wherein chelating agent is selected from the group comprising DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), DTPA (diethylene triamine-N,N,N',N",N"-pentaacetate)/pentetic acid, EDTA (Ethylenediamine tetraacetic acid), calcium disodium edetate or their salts and combinations thereof.
5. The formulation of claim 1, wherein the formulation is a ready to use solution.

6. The formulation of claim 1, wherein the formulation is a ready to dilute solution.
7. A ready to use parenteral formulation of vasopressin comprising:
a) vasopressin
b) stabilizer comprising
(i) one or more buffers and
(ii) one or more excipients selected from amino acids or chelating agents and
c) one or more additional excipients
wherein the formulation is free of acetate buffer
8. The formulation of claim 7, wherein the concentration of vasopressin ranges from 0.01 units/ml to 2.5 units/ml.
9. A ready to dilute parenteral formulation of vasopressin comprising:
a) vasopressin
b) stabilizer comprising
(i) one or more buffers and
(ii) one or more excipients selected from amino acids or chelating agents and
c) one or more additional excipients
wherein the formulation is free of acetate buffer
10. The formulation of claim 9, wherein the concentration of vasopressin
ranges from 2.5units/ml to 100 units/ml.

Documents

Orders

Section Controller Decision Date
section 15 RAMESH VANAPARTHI 2022-08-30
section 15 RAMESH VANAPARTHI 2022-08-30

Application Documents

# Name Date
1 201741046283-PROVISIONAL SPECIFICATION [22-12-2017(online)].pdf 2017-12-22
2 201741046283-FORM 1 [22-12-2017(online)].pdf 2017-12-22
3 201741046283-FORM 3 [21-12-2018(online)].pdf 2018-12-21
4 201741046283-ENDORSEMENT BY INVENTORS [21-12-2018(online)].pdf 2018-12-21
5 201741046283-COMPLETE SPECIFICATION [21-12-2018(online)].pdf 2018-12-21
6 Form 5_After Filling_17-01-2019.pdf 2019-01-17
7 Form 3_After Filling_17-01-2019.pdf 2019-01-17
8 Form 1_After Filling_17-01-2019.pdf 2019-01-17
9 Correspondence by Applicant_F1, F3 and F5_17-01-2019.pdf 2019-01-17
10 Correspondence by Applicant_Demand Draft_17-01-2019.pdf 2019-01-17
11 201741046283-FORM FOR SMALL ENTITY [09-03-2021(online)].pdf 2021-03-09
12 201741046283-EVIDENCE FOR REGISTRATION UNDER SSI [09-03-2021(online)].pdf 2021-03-09
13 201741046283-RELEVANT DOCUMENTS [01-07-2021(online)].pdf 2021-07-01
14 201741046283-RELEVANT DOCUMENTS [01-07-2021(online)]-1.pdf 2021-07-01
15 201741046283-PETITION UNDER RULE 137 [01-07-2021(online)].pdf 2021-07-01
16 201741046283-FORM 13 [01-07-2021(online)].pdf 2021-07-01
17 201741046283-AMENDED DOCUMENTS [01-07-2021(online)].pdf 2021-07-01
18 201741046283-FORM 18 [28-09-2021(online)].pdf 2021-09-28
19 201741046283-FER.pdf 2021-11-12
20 201741046283-POA [11-05-2022(online)].pdf 2022-05-11
21 201741046283-FORM-26 [11-05-2022(online)].pdf 2022-05-11
22 201741046283-FORM FOR SMALL ENTITY [11-05-2022(online)].pdf 2022-05-11
23 201741046283-FORM 13 [11-05-2022(online)].pdf 2022-05-11
24 201741046283-EVIDENCE FOR REGISTRATION UNDER SSI [11-05-2022(online)].pdf 2022-05-11
25 201741046283-AMENDED DOCUMENTS [11-05-2022(online)].pdf 2022-05-11
26 201741046283-Information under section 8(2) [12-05-2022(online)].pdf 2022-05-12
27 201741046283-FORM 3 [12-05-2022(online)].pdf 2022-05-12
28 201741046283-FER_SER_REPLY [12-05-2022(online)].pdf 2022-05-12
29 201741046283-CORRESPONDENCE [12-05-2022(online)].pdf 2022-05-12
30 201741046283-COMPLETE SPECIFICATION [12-05-2022(online)].pdf 2022-05-12
31 201741046283-CLAIMS [12-05-2022(online)].pdf 2022-05-12
32 201741046283-ABSTRACT [12-05-2022(online)].pdf 2022-05-12
33 201741046283-US(14)-HearingNotice-(HearingDate-17-08-2022).pdf 2022-06-06
34 201741046283-FORM-26 [16-08-2022(online)].pdf 2022-08-16
35 201741046283-Correspondence to notify the Controller [16-08-2022(online)].pdf 2022-08-16
36 201741046283-Written submissions and relevant documents [23-08-2022(online)].pdf 2022-08-23
37 201741046283-PatentCertificate30-08-2022.pdf 2022-08-30
38 201741046283-IntimationOfGrant30-08-2022.pdf 2022-08-30
39 201741046283-FORM-27 [30-09-2024(online)].pdf 2024-09-30

Search Strategy

1 search201741046283E_10-11-2021.pdf
2 InpassE_10-11-2021.pdf

ERegister / Renewals

3rd: 26 Oct 2022

From 22/12/2019 - To 22/12/2020

4th: 26 Oct 2022

From 22/12/2020 - To 22/12/2021

5th: 26 Oct 2022

From 22/12/2021 - To 22/12/2022

6th: 26 Oct 2022

From 22/12/2022 - To 22/12/2023

7th: 21 Dec 2023

From 22/12/2023 - To 22/12/2024

8th: 30 Nov 2024

From 22/12/2024 - To 22/12/2025

9th: 20 Sep 2025

From 22/12/2025 - To 22/12/2026

10th: 20 Sep 2025

From 22/12/2026 - To 22/12/2027