Specification
BACKGROUND OF THE INVENTION
Arthritic disorders, including rheumatism, osteoarthritis, dysplasia, lupus, bursitis, and gout are all characterized by inflammation and pain in bones, joints, muscles, and related connective tissues. Most of the forms are progressive. Inflammation is the end result of long term oxidative stress. Bone and joint inflammation is a scourge of both animals and humans. Those who suffer from inflammation experience pain and discomfort and may, in advanced cases, lose the effective use of inflamed joints. Thus, the goal of therapeutic methods for treating bone or joint inflammation is the relief of pain and discomfort and the restoration of the use of inflamed joints.
Certain enzymes appear to play a role in causing inflammation. One of the features of inflammation is increased oxygenation of arachidonic acid which is metabolized by two enzymatic pathways—the cyclooxygenase (CO) and the 5-lipoxygenase (5-LO) pathways—leading to the production of prostaglandins and leukotrienes, respectively. Prostaglandins and leukotrienes are mediators of inflammation. Therapies designed to inhibit cyclooxygenase and/or lipoxygenase activity are therefore of great interest.
There are two forms of the cyclooxygenase enzyme: cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). The latter form, i.e., COX-2, appears to play a key role in inflammatory processes. Recent scientific studies suggest that inhibiting the COX-2 enzyme may be an effective way to reduce inflammation without the side effects associated with irreversible COX-1 inhibition. In addition, recent scientific studies also suggest that COX-2 inhibition may serve an important function in promoting normal cell growth in the colon, pancreas, breast tissue and other organ systems.
Drugs are being developed which are intended to selectively inhibit COX-2 with minimal effect on COX-1. However, despite the emphasis on COX-2 inhibition, these drugs appear to have serious side effects, e.g., a breakdown in digestive protective mucus and prevention of normal healing processes. For example, non-steroidal anti-inflammatory drugs (NSAIDS) can have a variety of toxic side effects such as, e.g., gastric erosion and adverse effects on kidneys and liver, and may inadequately regulate the cellular immune functions and secretions of various cytokines.
Herbal therapies have been used in medical practice for centuries. Herbal therapies may increase the effectiveness of modern drug treatments or replace them completely. The compositions and methods of the present invention may be used for preventing and treating diseases in which inflammation is a common basis or contributing cause to the disease. In particular, the compositions and methods of the present invention may be used as both pharmaceutically active and supplement preparations to prevent or treat inflammation and the various diseases that, result from inflammationr.
This invention relates to herbal pharmaceutical compositions and supplements comprising Scutellaria baicalensis, Acacia catechu and compounds selected from Collagen peptide type-I & type-II5 Chondroitin sulphate, MSM, Sodium Hyaluronate, Curcumin & Curcumin bio active forms, Rosehip powder & Rosehip extracts, Ascorbic acid, Vitamin D3, Calcium salt, Boseweillia Serrata, Devils claw, Super oxide dismutase, Glucosamine, Vitamins, Probiotics, Amino acids and Minerals such as Copper, sulphate, Selenium, Zinc, Calcium, Magnesium and others that can be used to prevent and treat inflammation. The present invention further relates to methods of using such herbal composition to reduce inflammation in bones and joints. In particular, the present invention is based on novel combinations of herbal extracts to prepare herbal pharmaceutical compositions and herbal supplements for treating inflammation.
Scutellaria baicalensis (of the Labiatae family) is a plant sometimes referred to as Huang qin or Scutellaria radix (when referring to the root) and has usage in Traditional Chinese Medicine (TCM) for the treatment of cardiovascular disease, bleeding disorders (hematemesis, hematuria, and metrorrhagia). The related plant, Scutellaria lateriflora, is commonly referred to as Skullcap; this term is sometimes also applied to Scutellaria baicalensis along, with the names 'Golden Root' (this name also applies to Rhodiola Rosea by pure chance).
Scutellaria baicalensis comprising Baicalin (Baicalein-7-glucuronide) and its aglycone baicalein, as well asanother glycoside known as baicalein-7-O-glucoside, Wogonoside (wogonin-7-glucuronide) and itsaglycone, Wogoninas well as another glycoside known as Wogonin-5-O-glucoside, Oroxylin A {5,7-dihydroxy-6-methoxyflavone) and its 7-O-glucoside, Neobaicalein, Scutellarin and Isoscutellarein' Chrysin,Viscidulin I and Visdulin III, Skullcapflavone I and II, (2R,3R)-2',3,5,6',7-pentahydroxyflavanone, (2S)-5,7,2',6'-tetrahydroxyflavanone, (2S)-5,7-dihydroxy-6-methoxyflavanone,5,7,2'-trihydroxy-658-dimethoxyflavone (K36), 6,2'-dihydroxy-5,7,8?6'-tetramethoxyflavone? 5?7,4'-trihydroxy-8-methoxyflavone, Apigenin (as 6-C-glucoside 8-C-arabinoside), Luteolin and 6-hydroxyluteolin, Carthamidin (as 7-0-glucuronic acid) and Isocarthamidin-7-O-glucuronic acid.
Flavonoids or bioflavonoids are a widely distributed group of natural products, which have been reported to have antibacterial, anti-inflammatory, antiallergic, antimutagenic, antiviral, antineoplastic, anti-thrombic and vasodilatory activity. The structural unit common to this group of compounds includes two benzene rings on either side of a 3-carbon ring as illustrated by the following general structural formula:
The flavonoids wogonin and baicalein (as well as their glycosides) are commonly seen as the main active ingredients of Scutellaria baicalensis, although there are some other unique flavonoids (namely Oroxylin A and K36) that underlie some of the benefits of this plant. The main bioactives are highly present in the roots while not in high levels in the aerial parts (stem and leaves). Due to having higher concentrations of the . unique bioactives, the main part of the plant that is consumed is the root extract.
The Acacia catechu is known as Cutch tree,. Terra Japonica as well as Black Catechu. This herb was previously known as Kat or Cacho. The tree of Acacia catechu is found all throughout India. The main areas for its habitat in the country are the eastern slopes of the Western Ghats and the Himalayan tracts. The Acacia catechu Plant is known to have the following medicinal properties such as astringent, Bactericide. Refrigerant, Stimulant, Masticator and Expectorant. The plant of Acacia catechu contains tannins and Flavonoids majorly. The extract of heartwood, flowering tops, young shoots, the bark, fruits and the gum of the plant are used to create products for use. These extracts are used as an anodyne, bactericide, refrigerant, detergent, astringent, styptic, masticatory, expectorant, stimulant and as an antiphlogistic. This invention further relates to the new combination therapy for inflammatory disorders comprising Scutellaria, Acacia catechu and the compounds as whole or any one of the compound selected from Collagen peptide type-I & type-II, Chondroitin sulphate, Methyl sulfonyl Methane, Sodium Hyaluronate, Curcumin & Curcumin bio active forms, Rosehip powder & Rosehip extracts, Ascorbic acid, Vitamin D3, Calcium salt, Boseweillia Serrata, Devils claw, Super oxide dismutase, Glucosamine, Vitamins, Probiotics, Amino acids and Minerals such as Copper sulphate/Selenium/Zinc/Calcium/Magnesium and others.
The invention also relates to methods for using such herbal pharmaceutical compositions and supplements to treat a variety of diseases which have an inflammatory component.
A variety of chronic diseases have inflammation as an underlying or additional component. Treatment of the inflammation may therefore be useful, and sometimes essential, to cure the disease. In particular, a variety of > ^oigOpiigf^i^pj^tery diseases, -cardiovascular diseases, neurological diseases, bone and joint diseases, muscular and skeletal diseases, cancers and diabetes and obesity related complications have inflammatory components.
The present invention provides novel compositions of herbal extracts such as chewable tablets, film coated tablets, mouth melt granules, Liquid suspension, Dry suspension and Gummies that is easily administered to an infant or adult. Till now new dosage forms of Scutellaria, Acacia Catechu and new combinations were not reported anywhere. These new compositions of herbal extracts enhance the therapeutic efficacy of herbal compositions treating inflammatory disorders.
Compositions such as Chewable tablets, Mouth melt granules, Dry suspension, Liquid suspension and Gummies are a convenient alternative to conventional tablets. When taken directly by mouth or added to food or infant formula, the composition has a desirably bland flavor and is easy to consume. They have the great advantage of not requiring water, which means that they can be taken at any time and in any place. When used in combination with other dosage forms, these compositions offer additional variety for patients, improving the experience and ensuring better compliance. Compositions such as Chewable tablets, Mouth melt granules and Gummies can be made with a 'fizzy5 effect which stimulates saliva and makes the experience more enjoyable. For people with dysphagia (difficulty swallowing), these compositions are an excellent alternative to conventional tablets. In addition, these compositions reduce the risk of drug-induced esophagitis - when a tablet is caught in the esophagus and dissolves while remaining in contact with the sensitive esophagus lining. Chewable tablets can help to avoid this problem. The benefits of chewable tablets create a more 'user-friendly5 experience, eliminate need to take water with tablets, increase compliance, convert poorly soluble APIs into user-friendly form, overcome swallowing difficulties and reduce the risk of esophagitis.
A Mouth dissolving granules results with more rapid drug absorption from the pre-gastric area i.e. mouth, pharynx and oesophagus which may produce rapid onset of action. This dosage form allow high drug loading and have sufficient strength to withstand the rigors of the manufacturing process and post manufacturing handling. The advantages of mouth dissolving granules includes ease of administration to the patient who cannot swallow, no need of water to swallow the dosage form, rapid dissolution and absorption of the drug which will produce quick onset of action. Pre-gastric absorption from Mouth dissolving granules can result in improved bioavailability, reduced dose and improved clinical performance by reducing side effects..
Gummy bears contain medication in a flavored gummy candy and Good for children. Gummies are generally gelatin based dosage forms and can be considered as lozenges and troches. One has to only go to the local pharmacy or discount store to find numerous types of gummy bear supplements containing a wide range of active ingredients including vitamins, minerals, omega-3 oils, fibers, Echinacea and other dietary supplement actives. The dosage form has become exceedingly popular; The forms generally contain gelatin, natural or artificial sweeteners, natural or artificial colors, citric acid as an acidulent, flavors and materials such as coconut oil, beeswax, or starch to prevent sticking.
SUMMARY OF THE INVENTION
The present invention relates to an herbal pharmaceutical composition or herbal supplement composition which comprises a water extract or standardized hydroalcoholic extract of Scutellaria baicalensis and Acacia catechu.
The present invention relates to an herbal pharmaceutical composition or herbal supplement composition further comprises a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract, a bark extract, a flower extract, a fruit extract of Acacia catechu and a whole plant or roots of Scutellaria baicalensis.
In one aspect of the present invention, an herbal composition for treatment of inflammatory disorders, the composition comprising: a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract,.a bark extract, a flower extract, a fruit extract of Acacia catechu, a whole plant or roots of Scutellaria baicalensis and Collagen peptide type-I & type-II - peptide.
In another aspect, the present invention provides an herbal composition for treatment of inflammatory disorders, the composition comprising a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract, a bark extract, a flower extract, a fruit extract of Acacia catechu, a whole plant or roots of Scutellaria baicalensis and Chondroitin sulphate.
Additional embodiments of the compositions of the present invention include a herbal composition for treatment of inflammatory disorders, the composition comprising: a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract, a bark extract, a flower extract, a fruit extract of Acacia catechu, a whole plant or roots of Scutellaria baicalensis and methyl sulfonyl methane.
Yet another aspect, the present invention provides a herbal composition for treatment of inflammatory disorders, the composition comprising: a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract, a bark extract, a flower extract, a fruit extract of Acacia catechu, a whole plant or roots of Scutellaria baicalensis and Sodium hyaluronate.
Additional embodiments of the compositions of the present invention provide an herbal composition for treatment of inflammatory disorders, the composition comprising: a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract, a bark extract, a flower extract, a fruit extract of Acacia catechu, a whole plant or roots of Scutellaria baicalensis and Curcumin.
In another aspect, the present invention provides a herbal composition for treatment of inflammatory disorders, the composition comprising: a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract, a bark extract, a flower extract, a fruit extract of Acacia catechu, a whole plant or roots of Scutellaria baicalensis and Rosehip powder & Rosehip extracts.
Yet another aspect, the present invention provides an herbal composition for treatment of inflammatory disorders, the composition comprising: a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract, a bark extract, a flower extract, a fruit extract of Acacia catechu, a whole plant or roots of Scutellaria baicalensis and Ascorbic acid.
Yet another aspect, the present invention provides an herbal composition for treatment of inflammatory disorders, the composition comprising: a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract, a bark extract, a flower extract, a fruit extract of Acacia catechu, a whole plant or roots of Scutellaria baicalensis and Vitamin D3.
In one aspect of the present invention, a herbal composition for treatment of inflammatory disorders, the composition comprising: a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract, a bark extract, a flower extract, a fruit extract of Acacia catechu, a whole plant or roots of Scutellaria baicalensis and Calcium salt.
In another aspect, the present invention provides a herbal composition for treatment of inflammatory disorders, the composition comprising: a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract, a bark extract, a flower extract, a fruit extract of Acacia catechu, a whole plant or roots of Scutellaria baicalensis and Boseweillia Serrata- he resin of Boswellia species.
Yet another aspect of the invention provides composition comprising a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract, a bark extract, a flower extract, a fruit extract of Acacia catechu, a whole plant or roots of Scutellaria baicalensis and Devils claw.
In another aspect, the present invention provides an herbal composition for treatment of inflammatory disorders, the composition comprising: a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract, a bark extract, a flower extract, a fruit extract of Acacia catechu, a whole plant or roots of Scutellaria baicalensis and Glucosamine.
In another aspect, the present invention provides a herbal composition for treatment of inflammatory disorders, the composition comprising: a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract, a bark extract, a flower extract, a fruit extract of Acacia.catechu, a whole plant or roots of Scutellaria baicalensis and Vitamins or probiotics or amino acids or Minerals such as copper sulphate. Selenium, Zinc, Calcium, Magnesium and others.
In another aspect, the present invention provides a herbal composition comprising Scutellaria baicalensis, Acacia catechu and compounds such as Collagen peptide type-I & type-II, Chondroitin sulphate, Methyl sulfonyl Methane, Sodium Hyaluronate, Curcumin & Curcumin bio active forms, Rosehip powder & Rosehip extracts, Ascorbic acid, Vitamin D3, Calcium salt, Boseweillia Serrata, Devils claw, Super oxide-dismutase, Glucosamine, Vitamins B Group, Probiotics, Amino acids and Minerals such as Copper sulphate, Selenium, Zinc, Calcium, Magnesium and others.
The methods of the present invention may be used to prevent or treat an inflammation-associated cardiovascular and muscular disease selected from the group consisting of coronary artery disease, carotid artery disease, peripheral artery disease, cerebral artery disease, migraine, fibromyalgia, hypertension, stroke, erectile dysfunction, cardiomyopathy, and heart failure.
In another aspect, the methods of the present invention may be used to prevent or treat an inflammation-associated neurological and neurodegenerative disease selected from the group consisting of depression, chronic fatigue syndrome, sleep disorders, Alzheimer's disease, dementia, Parkinson's disease, and amyotrophic lateral sclerosis.
In another aspect, the methods of the present invention may be used to prevent or treat an inflammation-associated disease selected from the group consisting of inflammatory bowel disease (IBD), chronic obstructive pulmonary disease (COPD), rheumatoid arthritis (RA), psoriasis, lupus, chronic pancreatitis, hepatitis, fatty . liver disease, cirrhosis, nephritis, kidney dysfunction, cervicitis, pelvic and vaginal inflammation, prostatitis, and benign prostatic hyperplasia.
In yet another aspect, the methods of the present invention may be used to prevent or treat an inflammation-associated bone and skeletal disease selected from the group consisting of osteoporosis, osteoarthritis, degenerative disc disease, and muscular dystrophy.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
The present invention is directed to novel herbal pharmaceutical compositions and novel combinations which are used to treat and prevent variety of inflammatory disorders. The invention also provides methods for preparing and method for using these pharmaceutical compositions and combinations thereof.
This invention also relates to an novel combinations of herbal therapy comprising Scutellaria baicalensis, Acacia catechu and compounds selected from Collagen peptide type-I & type-II, Chondroitin sulphate, Methyl sulfonyl Methane, Sodium. Hyaluronate, Curcumin & Curcumin bio active forms, Rosehip powder & Rosehip extracts, Ascorbic acid, Vitamin D3, Calcium salt, Boseweillia Serrata, Devils claw, Super oxide dismutase, Glucosamine, Vitamins, Probiotics, Amino acids and Minerals such as Copper sulphate, Selenium, Zinc, Calcium, Magnesium and others.
In another embodiment, the present invention is directed to an herbal pharmaceutical composition comprising Scutellaria baicalensis, Acacia catechu and compounds selected from Collagen peptide type-I & type-II, Chondroitin sulphate, Methyl sulfonyl Methane, Sodium Hyaluronate, a standardized water or hydroalcoholic extract of Curcumin & Curcumin bio active forms, a standardized water or hydroalcoholic extract of Rosehip powder & Rosehip extracts.
Inflammation is a process by which the body's white blood cells and substances they produce protect us from infection with foreign organisms, such as bacteria and viruses. However, in some diseases, like arthritis, the body's defense system — the immune system — triggers an inflammatory response when there are no foreign invaders to fight off. In these diseases, called autoimmune diseases, the body's normally protective immune system causes damage to its own tissues. The body responds as if normal tissues are infected or somehow abnormal.
Accumulating evidence suggests that chronic inflammation may be a root cause of a wide range of progressive diseases, such as chronic inflammatory, cardiovascular, and neurological, bone, muscular and skeletal diseases, diabetes and metabolic diseases and cancer. The present invention relates to herbal pharmaceutical compositions and supplements which reduce or eliminate inflammation and therefore can be used to treat a variety of diseases having anti-inflammatory component.
In one embodiment, the present invention is directed to an herbal pharmaceutical composition comprising a water or hydroalcoholic extract of Scutellaria baicalensis and Acacia catechu.
Scutellaria baicalensis is also known as Chinese skullcap, Scute or Huang qin and most utilized herbs in >tfaditfDHa£(S|i|^^eXme4iQ|tit. Jts2r
Documents
Application Documents
| # |
Name |
Date |
| 1 |
6203-CHE-2015-AbandonedLetter.pdf |
2019-12-31 |
| 1 |
6203-CHE-2015-Form 5-181115.pdf |
2015-11-26 |
| 2 |
6203-CHE-2015-FER.pdf |
2019-06-28 |
| 2 |
6203-CHE-2015-Form 3-181115.pdf |
2015-11-26 |
| 3 |
6203-CHE-2015-Form 1-181115.pdf |
2015-11-26 |
| 3 |
6203-CHE-2015-Form 2(Title Page)-181115.pdf |
2015-11-26 |
| 4 |
6203-CHE-2015-Form 18-181115.pdf |
2015-11-26 |
| 5 |
6203-CHE-2015-Form 1-181115.pdf |
2015-11-26 |
| 5 |
6203-CHE-2015-Form 2(Title Page)-181115.pdf |
2015-11-26 |
| 6 |
6203-CHE-2015-FER.pdf |
2019-06-28 |
| 6 |
6203-CHE-2015-Form 3-181115.pdf |
2015-11-26 |
| 7 |
6203-CHE-2015-AbandonedLetter.pdf |
2019-12-31 |
| 7 |
6203-CHE-2015-Form 5-181115.pdf |
2015-11-26 |
Search Strategy
| 1 |
searchstrategy_26-06-2019.pdf |
| 1 |
TKDL_26-06-2019.pdf |
| 2 |
searchstrategy_26-06-2019.pdf |
| 2 |
TKDL_26-06-2019.pdf |