FORM 2 THE PATENTS ACT 1970 COMPLETE SPECIFICATION (SECTION 10) NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Glenmark Pharmaceuticals Limited an Indian Company having its registered office at B/2 Mahalaxmi Chambers 22, Bhulabhai Desai Road Mumbai- 400 026, India THE FOLLOWING SPECIFICATION DESCRIBES THE NATURE OF THE INVENTION: AND THE MANNER IN, WHICH IT IS TO BE PERFORMED Field of the Invention The present invention relates to novel heterocyclic compounds. More particularly the present invention relates to novel phosphodiesterase type 4 (PDE4) inhibitors having a heterocyclic structure, pharmaceutical compositions including such compounds, methods for their preparation and method for their use. Background of the Invention Airway inflammation characterizes a number of severe lung diseases including asthma and chronic obstructive pulmonary disease (COPD). Events leading to airway obstruction include edema of airway walls, infiltration of inflammatory cells into the lung, production of various inflammatory mediators and increased mucous production. The airways of asthmatic patients are infiltrated by inflammatory leukocytes, of which the eosinophil is the most prominent component. The magnitude of asthmatic reactions is correlated with the number of eosinophils present in lungs. The accumulation of eosinophils is found dramatically in the lungs of asthmatic patients although there are very few in the lungs of a normal individual. They are capable of lysing and activating cells and destroying tissues. When activated, they synthesize and release inflammatory cytokines such as IL-1, IL-3, TNF-a and inflammatory mediators such as PAF, LTD4 and related oxygen species that can produce edema, broncho-constriction. Tumor necrosis factor (TNF-a) was also known to be involved in the pathogenesis of a number of autoimmune and inflammatory diseases. Consequently, manipulation of the cytokine signaling or biosynthetic pathways associated with these proteins may provide therapeutic benefit in those disease states. It has been well demonstrated that TNF-a production in pro-inflammatory cells becomes attenuated by an elevation of intracellular cyclic adenosine 3',5'-monophosphate (cAMP). This second messenger is regulated by the phosphodiesterase (PDE) family of enzymes. The phosphodiesterase enzymes play an integral role in cell signaling mechanisms by hydrolyzing cAMP and cGP to their inactive 5' forms. Inhibition of PDE enzymes thus 2 results in an elevation of cAMP and /or cGP levels and alters intracellular responses to extra cellular signals by affecting the processes mediated by cyclic nucleotides. Since eosinophilis are believed to be a critical proinflammatory target for asthma, identification of the expression of PDE 4 gene family in eosinophils led to the PDE 4 as potential therapeutic target for asthma [Rogers, D.F., Giembycz, M.A., Trends Pharmacol. Set, 19, 160-164(1998); Barnes, P.J., Trends Pharmacol. ScL, 19, 415-423 (1998) herein incorporated by reference in their entirety]. The mammalian cyclic nucleotide phosphodiesterases (PDEs) are classified into ten families on the basis of their amino acid sequences and/or DNA sequence, substrate specificity and sensitivity to pharmacological agents [Soderling, S.H., Bayuga, S.J., and Beavo, J.A., Proc. Natl. Acad. Sci., USA, 96,7071-7076 (1999); Fujishige, K, Kotera, J., Michibata, H., Yuasa, K., Takebayashi, Si, Okamura, K. and Omori, K., J. Biol. Chem., 274, 18438-18445 (1999) herein incorporated by reference in their entirety]. Many cell types express more than one PDE and distribution of isoenzymes between the cells varies markedly. Therefore development of highly isoenzyme selective PDE inhibitors provides a unique opportunity for selective manipulation of various pathophysiological processes. Phosphodiesterase type 4 (PDE4) is an enzyme which regulates activities in cells which lead to inflammation in the lungs. PDE4, a cAMP-specific and Ca+2-independent enzyme, is a key isozyme in the hydrolysis of cAMP in mast cells, basophils, eosinophils, monocytes and lymphocytes. The association between cAMP elevation in inflammatory cells with airway smooth muscle relaxation and inhibition of mediator release has led to widespread interest in the design of PDE4 inhibitors[Trophy,T.J., Am. J. Respir. Crit. Care Med., 157, 351-370 (1998) herein incorporated by reference in their entirety]. Excessive or unregulated TNF-a production has been implicated in mediating or exacerbating a number of undesirable physiological conditions such as diseases including osteoarthritis, and other arthritic conditions; septic shock, ecdotoxic shock, respiratory distress syndrome, bone resorption diseases ; Since TNF-a also participates in the onset and progress of autoimmune diseases, PDE4 inhibitors may find utility as therapeutic agents for rheumatoid arthritis, multiple sclerosis and Crohn's disease. [Nature Medicine, \, 211-214 (1995) and ibid., 244-248 herein incorporated by reference in their entirety]. 3 Strong interest in Drugs capable of selective inhibition of PDE 4 is due to several factors such as (a) the tissue distribution of PDE-4 suggests that pathologies" related to the central nervous and immune systems could be treated with selective PDE-4 inhibitors (b) the increase in intracellular cAMP concentration, the obvious biochemical consequence of PDE-4 inhibition, has been well characterized in immuno-competent cells where it acts as a deactivating signal. Recently the PDE4 family has grown to include four subtypes - PDE4A to PDE4D, each encoded by a distinct gene {British Journal of Pharmacology; 1999; v.128; p. 1393-1398), herein incorporated by reference in its entirety. It has been demonstrated that increasing cAMP levels within these cells results in suppression of cell activation which in turn inhibits the production and release of pro¬inflammatory cytokines such as TNF-a. Since eosinophilis are believed to be a critical pro-inflammatory target for asthma, identification of the expression of the PDE-4 gene family in eosinophils led to the PDE-4 as potential therapeutic target for asthma. The usefulness of several PDE-4 inhibitors, unfortunately, is limited due to their undesirable side effect profile which include nausea and emesis (due to action on PDE-4 in the central nervous system) and gastric acid secretion due to action on PDE-4 in parietal cells in the gut. Barnette, M.S., Grous, M., Cieslinsky, L.B., Burman, M., Christensen, S.B., Trophy, T J., J. Pharmacol. Exp. Ther., 273,1396-1402 (1995) herein incorporated by reference in their entirety. One of the earliest PDE-4 inhibitor, Rolipram, was withdrawn from the clinical development because of its severe unacceptable side effect profile. Zeller E. et. al., Pharmacopsychiatry L7, 188-190 (1984) herein incorporated by reference in their entirety. The cause of severe side effects of several PDE-4 inhibitor molecules in human clinical trials has recently become apparent. There exist two binding sites on mammalian PDE-4 at which inhibitor molecules may bind. Also PDE-4 exists in two distinct forms which represent different conformations. They are designated as High affinity Rolipram binding site PDE-4H and Low affinity Rolipram binding site PDE-4L [Jacobitz, S., McLaughlin, M.M., Livi, G.P., Burman, M., Trophy, T.J., Mol. Pharmaco., 50, 891-899 (1996) herein incorporated by 4 reference in their entirety]. It was shown that certain side effects vomiting and gastric acid secretion) are associated with inhibition of PDE-4H whereas.some beneficial actions are associated with PDE-4L inhibition. It was also found that human recombinant PDE-4 exists in 4 isoforms A, B, C and D [Muller, T., Engels, P., Fozard, J.R., Trends Pharmacol. Sci., J7, 294-298 (1996) herein incorporated by reference in their entirety]. Accordingly, compounds displaying more PDE-4D isoenzyme selectivity over the A, B or C are found to have less amount of side effects than Rolipram [Hughes. B et.al., Br. J. Pharmacol 1996, 118, 1183-1191 herein incorporated by reference in their entirety]. Therefore, selective inhibitors of PDE-4 isozymes would have therapeutic effects in inflammatory diseases such as asthma and other respiratory diseases. Although several research groups all over the world are working to find highly selective PDE-4 isozyme inhibitors, so far success is limited. Various compounds have shown PDE-4 inhibition. 5 SmithKline Beecham's "Ariflo" which has the formula A, Byk Gulden's Roflumilast which has the formula U and Bayer's Bay-19-8004 which has the formula E have reached advanced stage of human clinical trials. Other compounds which have shown potent PDE-4 inhibitory activity include Celltech's CDP-840 of the formula B, Schering Plough's D-4418 of the formula C, Pfizer's 5CP-220,629 which has the formula F, Parke Davis's PD-168787 which has the formula G and Wyeth's Filaminast which has the formula H. However, recently due to efficacy and side effects problems, Ariflo, CDP-840 and Bay-19-8004 were discontinued from clinical trials as a treatment for asthma. Other compounds of the formulae C and F are presently undergoing phase-1 clinical trials. WO 9524381, herein incorporated by reference in its entirety, describes the compounds represented by the general formula 1 which have potent PDE4 inhibition activity. 6 (1) wherein Ri is OH or an ether or ester thereof, X is YR2, halogen, nitro, NR4R5 or formyl amine; Y is O or S(0)m, where m is 0,1 or 2; R2 is methyl or ethyl where either methyl or ethyl optionally substituted by 1 or more halogens; R3 is hydrogen, halogen, CM alkyl, CH2NHC(0)C(0)NH2, halo-substituted CM alkyl, -CH=CHR81R81,cyclopropyl optionally substituted by Rg1, CN, OR8, CH2OR8, NR8Rio, CH2NR8Rio, C(Z')H, C(0)ORs, C(O)NR8Ri0, or -C = CRg1; R4 and R5 are independently hydrogen or CI-2 alkyl; R7 is -(CR4R5)qRi2 or C1-6 alkyl wherein R]2 or Ci_6 alkyl group is optionally substituted one or more times by Ci_2 alkyl optionally substituted one to three groups selected from - F,-Br, -CI, -N02,-NRiORn,-C(=0)R8, -C(O)0R8, OR8,-CN, -C(=O)NR10R„ -OC(=O)NR10Ri,, -OC(=0)R8, -NR,OC(=0)NRioRii,NRioC(-0)OR9, NR10C(=O)Ri3, -C(=NR,o)NRioRii, -C(=N-CN)NRioRn, -C(=N-CN)SR9, -NRioC(=N-CN)NR10Rn, -NR10S(=O)2R9, -SCO^'Rg, -NR10C(=O)C(=O)NR10Rii, -NRioC(=0)C(=0)Rio, thiazolyl, imidazolyl, oxazolyl, pyrazolyl, triazolyl, or tetrazolyl; Rg is ~H or R9; R8' is R8 or fluorine; R9 is C1-4 alkyl optionally substituted by one to three -F; Rio is OR8, hydrogen, or C1.4 alkyl optionally substituted by one to three fluorines; Rn is -H or C1-4 alkyl optionally substituted by one to three -F; or when R[0 and Rn are as NRioRn may together with the nitrogen from 5 to 7 membered ring optionally containing at least one additional heteroatom selected from 0,N or S; R12 is C3.7 cycloalkyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyrimidyl, pyrazolyl, 1-imidazolyl, 2-imidazolyl, thiazolyl, triazolyl, pyrrolyl, piperazinyl, piperidinyl, morpholinyl, furanyl, 2-thienyl, 3-thienyl, 4-thiazolyl, quinolinyl, naphthyl or phenyl; 7 R13 is heterocyclic ring selected from oxazolidinyl, oxazolyl, thiazolyl, pyrazolyl, triazolyl, tetrazolyl, imidazolyl, imidazolidinyl, thiazoHdinyl, isoxazolyl, oxadiazolyl or thiadiazolyl, where R)3 is appended to a compound of formula (I) through a carbon of heterocyclic ring ,and where each heterocyclic ring may be unsubstituted or substituted by one or two Ci_2 alkyl groups; R14 is H or R7 or when R10 and R14 are as NR10R14, they may together with the nitrogen atom form a 5 to 7 membered ring optionally containing at least one additional heteroatom selected from O, N or S; m1 is 0,1 or 2; q is 0,1 or 2; Y1 is O or S Z is C^Y^Rn, C(=O)0R14, C(=Yl)NRioRi4,C(=NRio)NRioRi4,CN C(=NOR8)RI4, C(=0)NR8NR8C(=0)R8, C(=O)NR8NRi0Ri4, -C(=NORi4)R8, C(=NR8)NR10NR,4j C(=NRi4)NR8R8i C(=N-CN)NR,0Ri4, C(=N-CN)SR9, 2-imidazolyl, 4-imidazolyl,5- imidazolyl, 3-pyrazolyl, 4-pyrazolyl 5-pyrazolyl,4-triazolyl[l,2,3], 5-triazolyl[1,2,3], 3- triazolyl[ 1,2,4], 5-triazolyl[ 1,2,4], 5-tetrazolyl,2-oxazolyl,4-oxazolyl, 5-oxazolyl,3- isoxazolyl, 4-isoxazolyl, 5-isoxazolyl,3-oxadiazolyl[l,2,4], 5-oxadiazolyl[ 1,2,4], 2- oxadiazolyl[l,3,4], 2-thiazolyl[l,3,4], 2-thiazolyl, 4-thiazolyl, 5-thiazolyl,2-oxazolidinyl, 4-oxazolidinyl, 5-oxazoIidinyl, 2-thiazolidinyl, 4-thiazolidinyl or 5-thiazolidinyl,2- imidazolidinyl, 4-imidazolidinyl, or 5-imidazolidinyl; wherein all of the heterocyclic ring systems may be optionally substituted one or more times by R14; Z'is 0, NR9NOR8, NCN, C(-CN)2, CR8CN,CR8N02, CR8C(0)OR8, CR8C(0)NR8R8, C(- CN)N02, C(-CN)C(0)OR9, or C(-CN)C(0)NR8R8; US Patent. 4,012,495, herein incorporated by reference in its entirety, describes compounds of formula 2, which relates to racemic and optically active 4-(polyalkoxyphenyl)-2-pyrrolidones of general formula 2, which have potent PDE-4 inhibition activity. 8 Wherein Ri and R2 each are alike or different and are hydrocarbon of up to 18 carbon atoms or alkyl of 1-5 carbon atoms which are substituted by one or more of halogen atoms, hydroxyl, carboxy, alkoxy, alkoxycarbonyl, carboxamide and amino or substituted amino or collectively are alkylene of 1-3 carbon atoms; R3 is a hydrogen atom or methoxy; R4 is a hydrogen atom, alkyl, aryl or acyl; X is an oxygen atom or a sulfur atom. US Patent 5,128,358, herein incorporated by reference in its entirety, describes the compounds are represented by formula 3 , Wherein R is a polycycloalkyl group having from 7 to 11 carbon atoms; R2 is methyl or ethyl; XisOorNH;and Y comprises a 5- or 6- membered heterocyclic ring, especially a saturated or unsaturated 5- or 6- membered heterocyclic ring having one or two nitrogen atoms, said ring being optionally substituted with =0 or =S, provided that when said optional group is present and the heterocyclic ring comprises one nitrogen atom the optional group is located on a carbon atom adjacent to the said nitrogen atom ,and when the heterocyclic ring comprises two nitrogen atoms in a 1,3-position to one another said optional group is located on the carbon atom between the two nitrogen atoms; the nitrogen atoms of the heterocyclic rings 9 which bear a hydrogen atom being optionally substituted with (Ci_5)alkylv(G2-5)alkenyl, (Ci-s)alkanoyl, benzyl, phenlethyl or benzoyl; 1,2,3-thiadiazolyl 2,2 dioxide, the-nltrpgen atom of which are optically substituted with (Ci.5)alkyl,(C2-5)alkenyl,(Ci-5)alkanoyl, benzyl, pheylethyl or benzoyl; bicyclic heterocyclic moiety rings containing a total of three nitrogen atoms, one in each of the rings and one common to each ring (anular nitrogen). US Patent 5,814,651, herein incorporated by reference in its entirety, describes the comDounds reDresented bv formula 4. Wherein R1 is selected from the group consisting of methyl, ethyl, difluoromethyl, and trifluoroethyl; R2 is selected from the group consisting of (Ci-6) alkyl, alkoxyalkyl having 3 to7 carbons in the alkoxy portion and 2 to 4 carbons in the alkyl portion, phenoxyalkyl having 2 to 6 carbons in alkyl portion, (C3_7)cycloalkyl, (C8-9)polycycloalkyl, phenyl alkyl having 1 to 8 carbons in the alkyl portion. Phenyl amino alkyl having 2 to 6 carbons in alkyl portion and amino may be optionally substituted with (C1.4) alkyl and indanyl. Where the alkyl portion of the said alkyl, phenoxy alkyl cycloalkyl, polycycloalkyl, phenylalkyl and indanyl may optionally substituted with one or more fluorine atoms, -OH or (Ci_4) alkoxy, and the aryl portion of the phenylalkyl, phenoxyalkyl and indanyl may optionally be substituted with (Ci^)alkyl, (Ci.4)alkoxy or halogen; A and B are independently, selected from the group consisting of a covalent bond, optionally substituted (Ci_5) alkylene, optionally substituted (C2-5) alkenyl and optionally substituted phenylene, where the optionally substituted alkylene may be mono-substituted with (Ci.4)aIkoxy or C02R6 and hydroxyl. The optionally substituted alkenyl may be mono-substituted with (CM)alkoxy or C02R6 10 The optionally substituted phenylene may be mono-substituted with (CM)alkoxy, CO2R or hydroxyl wherein R6 is hydrogen or (Ci-4)alkyl Y is selected from the group consisting of a covalent bond, O, NR6 and S wherein R6 is as defined above; Z is selected from the group consisting of where Q1, Q2, Q3 and Q4 are independently N, CH or when also bonded-to B, C and provided that at least two of Q1, Q2, Q3 and Q4 are not N; : ' ; ,-■ X is selected from the group consisting of O, NR4 and S; and X1, X2, X3 and X4 are independently selected from the group consisting of O, NR4, S, C=0,CH2 and, when also bonded to B, CH; b is an integer from 1 to 2; e is an integer from 1 to 3; g is an integer from 1 to 4; j is an integer from 1 to 5; m is an integer from 1 to 7; each R3 is independently selected from the group consisting of hydrogen, halogen,(Ci_ 5)alkyl, CH(R7)C02R4, (C,.6)alkoxy,C02R4, CONR4R5, CONHOH, CH2NR4R5, NR4R5, nitro, hydroxyl, CN, S03H phenyl alkyl having 1 to 4 carbon atoms in alkyl portion, S02NR4R5, N(S02R5)2 and NHS02R5, Where R4 for each occurrence is independently selected from the group consisting of hydrogen,(Ci-6)alkyl, phenyl, optionally substituted with (Ci.C^alkyl or halogen, CH(R7)C02R5, (C3-C7)cycloalkyl, phenylalkyl having 1 to 4 carbon atoms in alkyl portion and dialkylaminoalkyl having a total of 5 carbons in the dialkylamino portion and having 2 to5 carbon atoms in alkyl portion where R6 is as defined above, R5 for each occurrence is independently selected from the group consisting of hydrogen, (Ci_6)alkyl, (C3_C7)cycloalkyl, phenylalkyl having 1 to 4 carbons in the alkyl portion, phenyl, pyridyl, pyrimidyl, thiazolyl and oxazolyl; or R4 and R3 are taken together with nitrogen to which they are attached and form an optionally substituted saturated or unsaturated 5- or 6-membered ring, a saturated or unsaturated 6-membered heterocyclic ring containing two hetero atoms or a quinoline ring optionally substituted with fluoro, where said optionally substituted saturated or unsaturated 5-or6-membered ring may be mono or di-substituted and each substituent is independently selected from the group consisting of alkyl having 1 to 4 carbons,C02R7 wherein R7 is as defined below, C0NH2, CON(CH3)2, oxo, hydroxyl, NH2, and N(CH3)2 and said saturated or unsaturated 6- 12 membered heterocyclic ring containing two heteroatoms has the second heteroatom selected from the group consisting of O, S, NH, NCH3, NCOCH3 and NCH2Ph; R7 for each occurrence is independently selected from the group consisting of*hydrogen and (CM)alkyl; and R8 is selected from the group consisting of (Ci-C6)alkyl, (C3-C7) cycloalkyl, phenyl and phenylalkyl having 1 to 4 carbons in the alkyl position; Accordingly we have prepared a novel series of compounds having the general formula I as defined below. We have examined the in vitro efficacy of these novel compounds against human PDE-4 enzyme and they have been found to show excellent PDE-4 enzyme inhibition activity. The compounds of the present invention are useful as therapeutic agents for inflammatory allergic diseases particularly bronchial asthma, allergic rhinitis and nephritis ; Since these compounds also inhibit the production of tumor necrosis factor (TNF), they may also find use in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, Crohn's disease, psoriasis ; diseases of the central nervous system such as depression amnesia, and dementia, Alzheimers disease, cardiac failure, shock, and cerebrovascular disease and the like; and insulin-resistant diabetes. Summary of the Invention Accordingly, the present invention provides novel heterocyclic compounds of the general formula (I), 13 wherein, R1 is independently selected for each occurrence from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstitued alkynyl, substituted or unsubstituted cycloalkyl, substituted, or unsubstituted cycloalkylakyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heterocyclic group, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted heteroarylalkyl,-C(0)-R',-C^O-R1, -C(0)NR1R1 and -S(0)m-R]; preferably R1 is substituted or unsubstituted cycloalkyl; R1 is further preferred to be cyclopentyl; wherein P is selected from the group consisting of direct bond, oxygen, sulfur or NR ; preferably P is oxygen; wherein P1 is selected from the group consisting of hydrogen, halogen atom, -OR , -S(0)m R], -CCOjR1 , formyl amine, nitro or -NRxRy (wherein Rx and Ry independently represents hydrogen atom, substituted or unsubstituted alkyl, haloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heteroarylalkyl ; preferably P1 is substituted or unsubstituted alkoxy; P is further preferred to be wherein m is 0,1 or 2; R is selected from the group consisting of hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, -CN, -CH=CR3R3, - C=C(R3), -CH2NHC(0)C(0)NH2, -(0)R3,CH20R3, -NR3R4, -N02, -CH2NR3R4, -C(Z)H, -C(0)OR3, -C(0)NR3R4 Z is 0, -NR5, -NOR3, -NCN, -C(-CN)2, -CR3CN, -CR3N02, -CR3C(0)OR3, 14 -CR3C(0)NR3R3, -C(-CN)N02, ~C(-CN)C(0)OR5, or -C(-gM)C(0)NRjRi; preferably R^ is-CN; \ ' where R4 is OR3 or R5 R3 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl and halogen; R5 is selected from the group consisting of hydrogen and substituted or unsubstituted alkyl; The ring 'A' is selected from the group consisting of substituted or unsubstituted aryl ring and optionally substituted saturated or unsaturated five to seven membered heterocyclic ring which contains one or more heteroatoms selected from the group consisting of O, S and NR1 ; the preferable rings can be selected from 15 wherein R6, R7 and R8 are independently chosen from the group consisting of hydrogen, hydroxy, halogen, cyano, nitro, formyl, substituted or unsubstituted : alk^l/:,, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted' or gnsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted heterocyclylalkyl ring, substituted or unsubstituted amino, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted cyclic ring, substituted or unsubstituted alkylcarbonyl, 'substituted or unsubstituted alkylcarbonyloxy, substituted or unsubstituted carboxylic acid or S(0)mR6 where m is 0,1 or 2 and R6 is as described above. R9 and R10 are independently selected from the group consisting of hydrogen, hydroxy, halogen, nitro, cyano, formyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted heterocyclylalkyl ring, substituted or unsubstituted amino, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted cyclic ring, substituted or unsubstituted alkylcarbonyl, 'substituted or unsubstituted alkylcarbonyloxy, substituted or unsubstituted carboxylic acid or R9 and R10 may be joined to a form a optionally substituted saturated or unsaturated cyclic ring, which may optionally include up to two heteroatoms selected from 0, NR6 or S; and R11, R , and R1J are independently selected from the group consisting of hydrogen, hydroxy, halogen, cyano, nitro, formyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted 16 arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted^'heterocyclylalkyl ring, substituted or unsubstituted amino, substituted or unsubstituted alkokycarbonyl, substituted or unsubstituted cyclic ring, substituted or unsubstituted alkylcarbonyl, 'substituted or unsubstituted alkylcarbonyloxy, substituted or unsubstituted carboxylic acid or S(0)mR6 where m is 0,1 or 2 and R6 is as described above. The A ring is further preferred to be selected from the group consisting of The substructure; would correspond to a structural formula of 17 represents the A ring apended to the cyclohexyl ring of formula I. For example, where A represents according to formula I. Compounds according to formula I further include their analogs, their tautomers, their regioisomers, their diasteromers, their stereoisomers, their geometrical isomers, their N-oxides, their polymorphs, their pharmaceutical ly acceptable salts, and their pharmaceutically acceptable solvates thereof. Detailed Description of the Invention The term 'alkyl' refers to a straight or branched hydrocarbon chain radical having from one to eight carbon atoms, and which is attached to the rest of the molecule by a single bond, examples include but are not limited to methyl, ethyl, n-propyl, and 1-methylethyl (isopropyl), n-butyl, n-pentyl, 1,1-dimethylethyl (t-butyl). The term "alkenyl" refers to aliphatic hydrocarbon group containing a carbon-carbon double bond and which may be a straight or branched chain radical having 2 to 10 carbon atoms which is attached to the rest of the molecule by a single bond. Examples include but are not limited to ethenyl, 1-propenyl, 2-propenyl (allyl), iso-propenyl, 2-methyl-1-propenyl, 1-butenyl, and 2-butenyl and the like. The term "alkynyl" refers to straight or branched chain hydrocarbon radicals having at least one carbon-carbon triple bond, having 2 to 12 carbon atoms (with radicals having in the range of about 2 up to 10 carbon atoms preferred) which is attached to the rest of the molecule by a single bond. Examples include but is not limited to ethynyl, propynyl, and butnyl. 18 The term "alkoxy" denPtes alkyl group as defined above attached via oxygen linkage to the rest of the molecule. Examples include but are not limited to -OGH3, -and -OC2H5. The term "alkylcarbonyl" denotes alkyl group as defined above attached via carbonyl linkage to the rest of the molecule. Examples include but are not limited to -C(0)CH3, and - C(0)C2H5. The term "alkoxycarbonyl" denotes alkoxy group as defined above attached via carbonyl linkage to the rest of the molecule. Examples include but are not limited to -C(0)-OCH3, and - C(0)-OC2H5- The term "alkylcarbonyloxy" denotes alkylcarbonyl group as defined above attached via oxygen linkage to the rest of the molecule. Examples include but are not limited to -0-C(0)CH3; and - 0-C(0)C2H5. The term "alkylamino" denotes alkyl group as defined above attached via amino linkage to the rest of the molecule- Examples include but are not limited to -NHCH3, -N(CH3)2 and N(CH3)(CH2CH3) The term "cycloalkyl" denotes a non-aromatic mono or multicyclic ring system of 3 to about 14 carbon atoms attached via a single bond to the rest of the molecule. Examples of monocyclic ring system include but are not limited to cyclopropyl, cyclobutyl, cyclopentyl and, cyclohexyl. Examples of multicyclic ring system include but are not limited to perhydronapththyl, adamantyl and norbornyl groups bridged cyclic group or sprirobicyclic groups e-g- sprio (4,4) non-2-yl. The term "cycloalkylalkyl" refers to cyclic ring-containing radical containing 3 to about 8 carbon atoms directly attached to alkyl group which is then attached to the main structure at any carbon from alkyl group that results in the creation of a stable structure, such as cyclopropylmethyl, cyclobutylethyl, cyclopentylethyl, and the like. The term "cycloalkenyl" refers to cyclic ring-containing radicals containing in the range of about 3 up to 8 carbon atoms with at least one carbon- carbon double bond. Examples include but are not liniited to cyclopropenyl, cyclobutenyl and cyclopentenyl. 19 The term "aryl" refers to aromatic radicals having 6 to 14 carbon atoms. Examples include but are not limited to phenyl, naphthyl, tetrahydronapthyl, indanyl and biphenyl. The term "arylalkyl" refers to an aryl ring as defined above directly bonded to an alkyl group as defined above. Examples include but are not limited to -CH2C6H5, and -C2H5C6H5. The term "heterocyclic ring" refers to a stable 3- to 15 membered ring which consists of carbon atoms and from one to five heteroatoms selected from the group consisting of nitrogen, phosphorus, oxygen and sulfur. For purpose of this invention, the heterocyclic ring radical may be a monocyclic, bicyclic or tricyclic ring system, which may include fused, bridged or spiro ring systems, and the nitrogen, phosphorus, carbon, oxygen or sulfur atoms in the heterocyclic ring radical may be optionally oxidized to various oxidation states. In addition, the nitrogen atom may be optionally quaternized; and the heterocyclic ring radical may be partially or fully saturated or aromatic (heteroaryl). Examples of such heterocyclic ring radicals include, but are not limited to, azetidinyl, acridinyl, benzodioxolyl, benzodioxanyl, benzofurnyl, carbazolyl, cinnolinyl, dioxolanyl, indolizinyl, naphthyridinyl, perhydroazepinyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pyridyl pteridinyl, purinyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrazoyl, imidazolyl, tetrahydroisouinolyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 2-oxoazepinyl, azepinyl, pyrrolyl, 4-piperidonyl, pyrrolidinyl, pyrazinyl, pyrimidinyl, pyridazinyl, oxazolyl, oxazolinyl, oxasolidinyl, triazolyl, indanyl, isoxazolyl, isoxasolidinyl, morpholinyl, thiazolyl, thiazolinyl, thiazolidinyl, isothiazolyl, quinuclidinyl, isothiazolidinyl, indolyl, isoindolyl, indolinyl, isoindolinyl, octahydroindolyl, octahydroisoindolyl, quinolyl, isoquinolyl, decahydroisoquinolyl, benzimidazolyl, thiadiazolyl, benzopyranyl, benzothiazolyl, benzooxazolyl, furyl, tetrahydrofurtyl, tetrahydropyranyl, thienyl, benzothienyl, thiamorpholinyl, thiamorpholinyl sulfoxide thiamorpholinyl sulfone, dioxaphospholanyl, oxadiazolyl, chromanyl and isochromanyl. The term "heteroarylalkyl" refers to heteroaryl ring radical as defined above directly bonded to alkyl group. The heteroarylalkyl radical may be attached to the main 20 structure at any carbon atom from alkyl group that results/in the creation of a stable structure. !-:: ,'■; :. ' i' J' / * •* The term "heterocyclylalkyl" refers to a heterocylic ring as defined above directly bonded to alkyl group. The heterocyclylalkyl radical may be attached to the main structure at carbon atom in the alkyl group that results in the creation of a stable structure. The term "cyclic ring" refers to a cyclic group containing 3-10 carbon atoms The term "Halogen" refers to radicals of Fluorine, Chlorine, Bromine, Iodine The substituents in the 'substituted alkyl', 'substituted alkoxy' 'substituted alkenyP ' substituted alkynyl' 'substituted cycloalkyP substituted cycloalkylalkyl' substituted cyclocalkenyl' 'substituted arylalkyl' 'substituted aryl' 'substituted heterocyclic ring', 'substituted heteroaryl ring,' 'substituted heteroarylalkyl', 'substituted heterocyclylalkyl ring', 'substituted amino', 'substituted alkoxycarbonyl', 'substituted cyclic ring' 'substituted alkylcarbonyP, 'substituted alkylcarbonyloxy' and 'substituted carboxylic acid' may be the same or different which one or more selected from the groups such as hydrogen, hydroxy, halogen, carboxyl, cyano, amino, nitro, oxo (=0), thio (=S), or optionally substituted groups selected from alkyl, alkoxy, alkenyl, alkynyl, aryl, arylalkyl, cycloalkyl, aryl, heteroaryl, heteroarylalkyl, heterocyclic ring, -COORx, -C(0)Rx, -C(S)RX, -C(0)NRxRy, -C(0)ONRxRy, -NRxCONRyRz, -N(Rx)S0Ry, -N(Rx)S02Ry, -(=N-N(Rx)Ry), - NRxC(0)ORy, -NRxRy, -NRxC(0)Ry-, -NRxC(S)Ry -NRxC(S)NRyRz, -SONRxRy-, -S02NRxRy-, -ORx, -ORxC(0)NRyRz, -ORxC(0)ORy~, -OC(0)Rx, -OC(0)NRxRy, -RxNRyRz, -RxRyRz, -RXCF3, -RxNRyC(0)Rz, -RxORy, -RxC(0)ORy, -RxC(0)NRyRz, -RxC(0)Rx, -RxOC(0)Ry, -SRx, -SORx, -S02Rx, -0N02,(wherein Rx, Ry and Rz in each of the above groups can be hydrogen atom, substituted or unsubstituted alkyl, haloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl substituted or unsubstitued heterocyclic ring, substituted or unsubstitued heterocyclylalkyl, substituted or unsubstitued heteroaryl or substituted or unsubstitued heteroarylalkyl) 21 Pharmaceutical ly acceptable salts forming part of this invention include salts derived from inorganic bases such as Li, Na, K, Ca, Mg, FeV.Gu, Zn, Mn; salts of organic bases such as N,N'-diacetylethylenediamine, glucamine, tfiethylamine, choline, choline hydroxide, dicyclohexylamine, metformin, benzylamine/ trialkylamine, thiamine, spermidine, and the like; alkyl halides such as methyl halide, ethyl halide and the like; Aryl alkyl halide such as benzylhalide and the like; chiral bases like alkylphenylamine, glycinol, phenyl glycinol and the like, salts of natural amino acids such as glycine, alanine, valine, leucine, isoleucine, norleucine, tyrosine, cystine, cysteine, methionine, proline, hydroxy proline, histidine, ornithine, lysine, arginine, serine, and the like; unnatural amino acids such as D-isomers or substituted amino acids; guanidine, substituted guanidine wherein the substituents are selected from nitro, amino, alkyl, alkenyl, alkynyl, ammonium or substituted ammonium salts and aluminum salts. Salts may include acid addition salts where appropriate which are, sulphates, nitrates, phosphates, perchlorates, borates, hydrohalides, acetates, trifluroacetate, tartrates, maleates, citrates, succinates, palmoates, methanesulphonates, benzoates, salicylates, benzenesulfonates, ascorbates, glycerophosphates, ketoglutarates and the like. Pharmaceutical ly acceptable solvates may be hydrates or comprise other solvents of crystallization such as alcohols. Another object of the invention is a method of treating inflammatory diseases, disorders and conditions characterized by or associated with an undesirable inflammatory immune response and all disease and conditions induced by or associated with an excessive secretion of TNF-a and PDE-4 which comprises administering to a subject a therapeutically affective amount of a compound according to claim 1. Another object of the invention is a method of treating inflammatory conditions and immune disorders in a subject in need thereof which comprises administering to said subject a therapeutically effective amount of a compound according to Formula I. Preferred inflammatory conditions and immune disorders are chosen from the group consisting of asthma, bronchial asthma, chronic obstructive pulmonary disease, allergic rhinitis, eosinophilic granuloma, nephritis, rheumatoid arthritis, cystic fibrosis, 22 chronic bronchitis, multiple sclerosis, Crohns disease, psoraisisV uticaria, adult vernal cojunctivitis, respiratory distress syndrome, rhematoid spondylitis, osteoarthritis, gouty arthritis, uteltis, allergic conjunctivitis, inflammatory bowel conditions, ulcerative coalitis, eczema, atopic dermatitis and chronic inflammation, Further preferred is when the inflammatory condition is an allergic inflammatory condition. Further preferred is when the inflammatory conditions and immune disorders are selected from the group consisting of inflammatory conditions or immune disorders of the lungs, joints, eyes, bowels, skin and heart. Further preferred is when the inflammatory condition is chosen from the group consisting of bronchial asthma, nepritis, and allergic rhinitis. Another object of the invention is a method for abating inflammation in an affected organ or tissue comprising delivering to said organ or tissue a therapeutically effective amount of a compound represented by a compound according to Formula 1. Another object of the invention is a method of treating diseases of the central nervous system in a subject in need thereof which comprises administering to said subject a therapeutically effective amount of a compound according to Formula 1. Preferred diseases of the central nervous system are chosen from the group consisting of depression, amnesia, dementia, Alzheimers disease, cardiac failure, shock and cerebrovascular disease. Another object of the invention is a method of treating insulin resistant diabetes in a subject in need thereof which comprises administering to said subject a therapeutically effective amount of a compound according to Formula 1. 23 "Treating" or "treatment" of a state, disorder or condition includes: (1) preventing or delaying the appearance of clinical sympto/ms, of the state, disorder or condition developing in a mammal that may be afflicted with tir predisposed to the state, disorder or condition but does not yet experience or display clinical or subclinical symptoms of the state, disorder or condition, (2) inhibiting the state, disorder or condition, i.e., arresting or reducing the development of the disease or at least one clinical or subclinical symptom thereof, or (3) relieving the disease, i.e., causing regression of the state, disorder or condition or at least one of its clinical or subclinical symptoms. The benefit to a subject to be treated is either statistically significant or at least perceptible to the patient or to the physician A "therapeutically effective amount" means the amount of a compound that, when administered to a mammal for treating a state, disorder or condition, is sufficient to effect such treatment. The "therapeutically effective amount" will vary depending on the compound, the disease and its severity and the age, weight, physical condition and responsiveness of the mammal to be treated. The four classic symptoms of acute inflammation are redness, elevated temperature. Swelling, and pain in the affected area, and loss of function of the affected organ. Symptoms and signs of inflammation associated with specific conditions include: • rheumatoid arthritis- pain, swelling, warmth and tenderness of the involved joints; generalized and morning stiffness; • insulin-dependent diabetes mellitus- insulitis; this condition can lead to a variety of complications with an inflammatory component, including: retinopathy, neuropathy, nephropathy; coronary artery disease, peripheral vascular disease, and cerebrovascular disease; 24 • autoimmune thyroiditis- wealoiess, constipation, shortness of breath, puffiness of the face, hands and feet, peripheral edema, bradycardia; • multiple sclerosis- spasticity, blurry vision, vertigo, limb weakness, paresthesias; • uveoretinitis-decreased night vision, loss of peripheral vision; • lupus erythematosus-joint pain, rash, photosensitivity, fever, muscle pain, puffiness of the hands and feet, abnormal urinalysis (hematuria, cylinduria, proteinuria), glomerulonephritis, cognitive dysfunction, vessel thrombosis, pericarditis; • scleroderma- Raynaud's disease; swelling of the hands, arms, legs and face; skin thickening; pain, swelling and stiffness of the fingers and knees, gastrointestinal dysfunction, restrictive lung disease; pericarditis,; renal failure; • other arthritic conditions having an inflammatory component such as rheumatoid spondylitis, osteoarthritis, septic arthritis and polyarthritis- fever, pain, swelling, tenderness; • other inflammatory brain disorders, such as meningitis, Alzheimer's disease, AIDS dementia encephalitis- photophobia, cognitive dysfunction, memory loss; • other inflammatory eye inflammations, such as retinitis- decreased visual acuity; • inflammatory skin disorders, such as , eczema, other dermatites (e.g., atopic, contact), psoriasis, burns induced by UV radiation (sun rays and similar UV sources)- erythema, pain, scaling, swelling, tenderness; • inflammatory bowel disease, such as Crohn's disease, ulcerative colitis- pain, diarrhea, constipation, rectal bleeding, fever, arthritis; • asthma- shortness of breath, wheezing; • other allergy disorders, such as allergic rhinitis- sneezing, itching, runny nose • conditions associated with acute trauma such as cerebral injury following stroke-sensory loss, motor loss, cognitive loss; • heart tissue injury due to myocardial ischemia- pain, shortness of breath; • lung injury such as that which occurs in adult respiratory distress syndrome-shortness of breath, hyperventilation, decreased oxygenation, pulmonary infiltrates; 25 • inflammation accompanying infection, such as sepsis, septic-shock, toxic shock syndrome- fever, respiratory failure, tachycardia, hypo'tensicin, leukocytosis; • other inflammatory conditions associated with particular organs or tissues, such as nephritis (e.g., glomerulonephritis)-oliguria, abnormal urinalysis; inflamed appendix- fever, pain, tenderness, leukocytosis; gout- pain, tenderness, swelling and erythema of the involved joint, elevated serum and/or urinary uric acid; inflamed gall bladder- abdominal pain and tenderness, fever, nausea, leukocytosis; chronic obstructive pulmonary disease- shortness of breath, wheezing; congestive heart failure- shortness of breath, rales, peripheral edema; Type II diabetes- end organ complications including cardiovascular, ocular, renal, and peripheral vascular disease lung fibrosis- hyperventilation, shortness of breath, decreased oxygenation; vascular disease, such as atherosclerosis and restenosis- pain, loss of sensation, diminished pulses, loss of function and alloimmunity leading to transplant rejection- pain, tenderness, fever. Subclinical symptoms include without limitation diagnostic markers for inflammation the appearance of which may precede the manifestation of clinical symptoms. One class of subclinical symptoms is immunological symptoms, such as the invasion or accumulation in an organ or tissue of proinflammatory lymphoid cells or the presence locally or peripherally of activated pro-inflammatory lymphoid cells recognizing a pathogen or an antigen specific to the organ or tissue. Activation of lymphoid cells can be measured by techniques known in the art. "Delivering" a therapeutically effective amount of an active ingredient to a particular location within a host means causing a therapeutically effective blood concentration of the active ingredient at the particular location. This can be accomplished ,e.g., by local or by systemic administration of the active ingredient to the host. 26 "A subject" or "a patient" or "a host" refers to mammalian animals, preferably human. , ■ ^ Some of the representative compounds according to the present invention are specified below but should not Construed to be limited thereto; 1 5-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5,6,7-hexahydro-li:f-indazole-5-carbonitrile. 2. 5-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-3-oxo-2,3,4,5,6,7-hexahydro-l//-indazole-5-carbonitrile. 3. 5-(3-Cyclopentyloxy-4-methoxyphenyl)-4,5,6,7-tetrahydro-li/-5-indazole-carbonitrile. 4. 5-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-4,5,6,7-tetrahydro-lff-5-indazolecarbonitrile. 5. 5-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-2-phenyl-4,5,6,7-tetrahydro-2//-indazole-5-carbonitrile. 6. 5-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-l-phenyl-4,5,6,7-tetrahydro-2H-indazole-5-carbonitrile. 7. 5-(3-Cyclopentyloxy-4-m^thoxyphenyl)-2-(2-pyidyl)-4,5,6,7-tetrahydro-2i:/-5-indazole-carbonitrile. 8. 5-(3-Cyclopentyloxy-4-methoxyphenyl)-l-methyl-4,5,6,7-tetrahydro-liJ-5-indazolecarbonitrile. 8B.5-(3-Cyclopentyloxy-4-methoxyphenyl)-l-methyl-4,5,6,7-tetrahydro-2//-5-indazolecarbonitrile. 9. 2-[5-Cyano-5-(3-Cyclopentyloxy-4-methoxyphenyl)-4,5,6,74etrahydro-li[/-l- indazoyl] acetic acid. 9B.2-[5-Cyano-5-(3-Cyclopentyloxy-4-methoxyphenyl)-4,5,6,7-tetrahydro-2i/-l-indazoyl] acetic acid. 10. 5-(3-CyclopentyIoxy-4-m6thoxyphenyl)-4,5,6,7-tetrahydrobenzo[c]isoxazole-5- carbonitrile. 27 11. 5-(3-Cyclopentyloxy-4-methoxyphenyl)-3-methyl-2-oxo-2,3,455,6,7-hexahydro-benzo[d][l,3]oxazole-5-carbonitrile. 12. 5-(3-Cyclopentyloxy-4-methoxyphenyl)-l-vinyl-4,5,6,7-tetrahydro-li/-5-indole-carbonitrile. 13. 5-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-l-vinyl-4,5,6J7-tetrahydro-l//-5-indolecarbonitrile. 14. S^S-Cyclopentyloxy^-methoxyphenyO^.S^J-tetrahydro-liZ-S-indole-carbonitrile. 15. 5-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-4,5,6,7-tetrahydro-li/-5-indazole-carbonitrile. 16. 5-(3-Cyclopentyloxy-4-methoxyphenyl)-l-methyl-4,5,6J7-tetrahydro-l//-5-indole-carbonitrile. 17. Ethyl 6-Cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-2-methyl-5,6,7,8-tetrahydro-3-quinolinecarboxylate. 18. 6-Cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-2-methyl-5,6,7,8-tetrahydro-3-quinolinecarboxylic acid. 19. 6-(3-Cyclopentyloxy-4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazoline-carbonitrile. 20. 6-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-4-oxo-3,4,5,637,8-hexahydro-6-quinazolinecarbonitrile. 21. 6-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazoline-carbonitrile. 22. 6'(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-2-methyl-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazolinecarbonitrile. 23. 2-Amino-6-(3-Cyclopentyloxy-4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazolinecarbonitrile. 24. 2-Amino-6-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazolinecarbonitrile. 25. 6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-methyl-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazolinecarbonitrile. 28 26. Ethyl 2-[6-cyano-6-(3-cyclopentyIoxy-4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-3-quinazolinyl]acetate. 27. 2-[6-Cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-3-quinazolinyl]acetic acid. 28. Ethyl 2-[6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-2-methyl-4-oxo-3,4,5,6,7,8-hexahydro-3-quinazolinyl]acetate. 28B.Ethyl 2-[6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-2-methyl-5,6,7,8-tetrahydro-4-quinazolinyloxy]acetate. 29. 6-(3-Cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-6- quinazol inecarbonitri le. 29A.6-(3-Cyclopentyloxy-4-methoxyphenyl)-l-oxo-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile. 30. 6-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-5,6,7,8-tetrahydro-6-quinazoline- carbonitrile. 31.6-(3-CycIopentyloxy-4-methoxyphenyl)-2-methyl-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile. 32. 2-Amino-6-(3-cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile. 33. 2-Amino-6-(3-cyclopentyloxy-4-difluoromethoxyphenyl)-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile. 34.Arl-[6-Cyano-6-(3-Cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-2-quinazolinylj-acetamide. 35. 2-[6-Cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-2-quinazolinylamino]-acetic acid. 36. 2-Methylthio-6-(3-cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-6-quinazoline-carbonitrile. 37. 2-Methanesulfonyl-6-(3-cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-6-quinazoline-carbonitrile. 38. 6-(3-Cyclopentyloxy-4-methoxyphenyl)-4-methoxy-5,6,7,8-tetrahydro-6-quinazoline-carbonitrile. 29 39. 6-(3-Cyclopentyloxy-4-methoxyphenyl)-4-methylamino-;5,,6J,8-tetra;hydro-6-quinazolinecarbonitrile. 40. 6-(3-Cyclopentyloxy-4-methoxyphenyl)-4-dimethylamino-5,67,84etfahydto-i6-quinazolinecarbonitrile. 41.4-«-Butylamino-6-(3-cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile. 42.6-0-C^dop^v^lo^-4-m^tb.o^yiph^^ylV4-mQ':ph'iU,?.o-5,6,7 ,&-teteahyd<:Hz, 2 H), 4.66 (dd, J = 8.8, 1.0 Hz, 1 H), 4.78-4.81 (m, 1 H), 5.05 (dd, J= 15.4, 1.0 Hz, 1 H), 6.07 (d, J= 2.8 Hz, 1 H), 6.55 (t, J= 75.3 Hz, 1 H), 6.79 (dd, J= 15.4, 8.9 Hz, 1 H), 6.94 (d„./ = 2.8 Hz, 1 H), 7.01 (dd, J= 8.4, 2.4 Hz, 1 H), 7.02-7.17 (m, 2 H). Example 14 5-(3-CyclopentyIoxy-4-methoxyphenyl)-4,5,6,7-tetrahydro-l/T-5-indole-carbonitrile To a well-stirred solution of 1-vinyl indole 12 (100 mg, 0.275 mmol) in THF-water (1:1) mixture (10 ml) was added mercuric acetate (96 mg, 0.301 mmol) and the mixture was stirred at room temperature for 2h to result a white precipitate. The mixture was treated with sodium borohydride (22 mg, 0.581 mmol) and stirred at room temperature for 10 min. The mixture was filtered through a celite bed to remove mercury salts. The filtrate was diluted with water and extracted with ethyl acetate (2 x 50 ml). The combined ethyl acetate extracts were washed with water (2 x 100 ml) and brine (50 ml). The EtOAc solution was dried (Na2S04) and evaporated under reduced pressure to give a brown residue. Purification of the product using silica gel chromatography using 20 % ethyl acetate in petroleum ether gave 65 mg (70 %) of the product as low melting solid. IR (neat) 3320, 2958, 2929, 2855, 2236, 1605, 1511, 1270, 1049 cm"1; !H NMR (300 MHz, CDCI3) 8 1.57-1.95 (m, 8 H), 2.30-2.36 (m, 2 H), 2.69 (dt, J= 12.0, 4.5 Hz, 1 H), 2.92-3.04 (m, 1 H), 3.13 (d, J= 15.6 Hz, 1 H), 3.19 (d, 15.6 Hz, 1 H), 3.85 (s, 3 H), 4.72-4.77 (m, 1 H), 6.01 (t, 7- 2.4 Hz, 1 H), 6.68 (t, J= 2.4 Hz, 1 H), 6.84 (d, J = 8.7 Hz, 1 H), 7.01-7.04 (m, 2 H), 7.86 (brs, 1 H) 61 Example 15 5-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-4,5,6,7-tetrahydr6-l^-5-indazole-carbonitrile Reaction of oxime intermediate 8 (500 mg, 1.372 mmol) with acetylene gas in presence of potassium hydroxide (60 mg, 1.069 mmol) in DMSO (10 ml) was stirred at 60-70°C 24hrs in sealed tube under acetylene gas, then cooled to RT and diluted with water (100ml) then extracted with ethyl acetate (2 X 100ml) then combined ethyl acetate solution was washed with water (3 X 300ml) followed by brine (100ml) dried over Na2S04 and evoparatation of ethyl acetate to give crude. This crud was purified by 60-120mesh silica gel column chromatography using 10% ethyl acetate in pet ether as solvent to give lOOmg as semi solid. IR (neat) 3329, 2959, 2929, 2236, 1511, 1270, 1049 cm"1; 'H NMR (300 MHz, CDC13) 8 1.63-1.95 (m, 8 H), 2.28-2.37 (m, 2 H), 2.65-2.74 (m, 1 H), 2.90-3.04 (m, 1 H), 3.08 (d, J= 15.9 Hz, 1 H), 3.19 (d, J= 15.7 Hz, 1 H), 4.76-4.81 (m, 1 H), 6.03 (t, J = 2.4 Hz, 1 H), 6.54 (t, J= 75.6 Hz, 1 H), 6.70 (t,J= 2.4 Hz, 1 H), 7.02 (dd, J= 8.1, 2.4 Hz, 1 H), 7.10-7.17 (m, 2 H), 7.87 (brs, 1 H). Example 16 62 5-(3-Cyclopentyloxy-4-methoxyphenyl)-l-methyl-4,5,6,7-tetrahydro-l/T-5-indole-carbonitrile To a stirred and cooled (0 °C) suspension of 50 % sodium hydride (8 mg, 0.166 mmol) in THF (5 ml) was added compound of example 14 (50 mg, 0.148 mmol) and the mixture was stirred at the sane temperature to result a brown solution. Methyl iodide (30 mg, 0.211 mmol) was then added and the mixture was stirred at 0 °C for 2 h. The mixtfurewas quenched with ice cold water (25 ml) and extracted with EtOAc (2 x 50 ml). The ethyl acetate solution was washed with water (2 x 50 ml), brine (50 ml) and dried (Na2S04). The residue obtained after evaporation of the solvent was purified by column chromatography on silica gel using 1 % methanol in chloroform to give 40 mg (76.8 %) of the product as white solid, mp 142-145 °C; IR(KBr) 3433, 2936, 2841, 2234, 1519, 1266, 1148, 1031 cm"1; 'H NMR (300 MHz,. CDC13) 5 1.59-1.93 (m, 8 H), 2.28-2.37 (m, 2 H), 2.62-2.68 (m, 1 H), 2.86-3.20 (m, 1 H), 3.05 (d, J= 15.6 Hz, 1 H), 3.06 (d, J= 15.6 Hz, 1 H), 3.50 (s, 3 H), 3.84 (s, 3 H), 4.72-4.76 (m, 1 H), 5.91 (d, ./= 3.0 Hz, 1 H), 6.52 (d, J= 2:4 Hz, 1 H), 6.83 (d, J= 9.3 Hz, 1 H), 7.01-7.04 (m, 2 H). Example 17 Ethyl 6-Cyano-6-(3-cyclopentyIoxy-4-methoxyphenyl)-2-methyl-5,6,7,8-tetrahydro-3-quinolinecarboxylate CO2C2H5 CH3 A mixture of intermediate 5 (300 mg, 0.814 mmol), ethylacetoacetate (127 mg, 0.971 mmol) and ammonium acetate (500 mg, 6.486 mmol) in acetic acid (10 ml) was stirred at 100-110 °C for 3 h under nitrogen atmosphere. The mixture was cooled to room temperature and diluted with water (100 ml). The mixture was extracted with ethyl acetate (2 x 100 ml), washed with water (2 x 100 ml) and dried over anhydrous Na2S04 and concentrated. The residue was purified by silica gel column chromatography using 25 % ethyl acetate in petroleum ether to give 200 mg (56.4 %) of the product as colorless liquid, 63 IR(Neat) 2957, 2230, 1722,1517, 1260,1146, 1021,781cm-1; /" 'H NMR (300 MHz, CDC13) 8 1.41 (t, J= 7.2 Hz, 3 H), 1.59-1.97;(m, 8 H), 2.32-2.43 (m, 1 H), 2.53-2.55 (m, 1 H), 2.81 (s, 3 H), 3.08-3.16 (m, 1 H), 3.25-3.41 (m, 3-H),3.86 (s, 3 H), 4.37 (q, J= 12 Hz, 2 H), 4.76-4.79 (m, 1 H), 6.86 (d, J= 8.4 Hz, 1 H), 6.96-7.CJ2 (m, 2 H), 7.96 (s, 1 H). Example 18 6-Cyano-6-(3-cycIopentyloxy-4-methoxyphenyl)-2-methyI-5,6,7,8-tetrahydro-3-quinolinecarboxylic acid COOH CH3 To a stirred solution of ester 17 (120 mg, 0.276 mmol) in ethanol (5 ml), was added IN aqueous NaOH solution (5 ml) and the mixture was stirred at room temperature for 16 h. Most of the solvent was evaporated under reduced pressure and the residue was diluted with water (15 ml). The basic aqueous solution was washed with ether (2 x 25 ml) and then acidified with 1 N HC1 solution to pH 2. The free acid was extracted into ethyl acetate and washed with water (50 ml). The organic extract was dried (Na2S04) and evaporated give 89 mg (79.2 %) the product as white solid, mp. 155-185 °C; IR(KBr) 3419, 2961, 2230, 1712, 1519, 1418, 1264, 1167, 1028,974,761cm"1; 'H NMR (300 MHz, CDC13) 8 1.59-1.99 (m, 8 H), 2.34-2.44 (m, 1 H), 2.50-2.57 (m, 1 H), 2.87 (s, 3 H), 3.15-3.42 (m, 4 H), 3.85 (s, 3 H), 4.75-4.79 (m, 1 H), 6.85 (d, J= 8.1 Hz, 1 H), 6.96-7.02 (m, 2 H), 8.10 (s, 1 H). 64 Example 19 ? 6-(3-Cyclopentyloxy-4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazoline-carbonitrile To a mixture of intermediate 1 (1.0 g, 2.692 mmol), formamidine acetate (980 mg, 9.413 mmol) and sodium methoxide (645 mg, 11.944 mmol) in methanol (30 ml) was stirred at 60-70 °C for 18 h under nitrogen. Most of the methanol was evaporated under reduced pressure and the residue was diluted with EtOAc (100 ml) and water (100 ml). The layers were separated and the organic layer was washed with water (3 x 50 ml), dried (Na2S04) and evaporated. The residue was purified by silica gel column chromatography using 2 % methanol in chloroform as eluent to afford 550 mg (55.9 %) of the product as white solid; mp 190-195 °C; IR(KBr) 3137, 2922,2233, 1652, 1639, 1619, 1522, 1418, 1276, 1154 1002 cm"1; 'H NMR (300 MHz, CDC13) 5 1.63-1.97 (m, 8 H), 2.23-2.31 (m, 1 H), 2.04-2.46 (m, 1 H), 2.84-2.93 (overlapping m, 1 H), 2.89 (d, 7= 17.8 Hz, 1 H), 3.10-3.24 (m, 1 H), 3.34 (d, J= 17.9 Hz, 1 H), 3.85 (s, 3 H), 4.73-4.82 (m, 1 H), 6.86 (d, J= 7.8 Hz, 1 H), 6.97-7.02 (m, 2 H), 8.06 (s,l H), 12.79 (brs, 1 H). Example 20 This was prepared as described in example 19 using intermediate 3 (200 mg, 0.490 mmol) and formamidine acetate (127 mg, 1.219 mmol) in presence of sodium methoxide 65 6-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazolinecarbonitrile (100 mg, 1.851 mmol). The product was purified by silica gel coluniri chromatography using 1 % methanol in chloroform to afford 60 mg (30.4 %) of the product as white solid; mp 110-115 °C; IR(KBr) 3154, 2963, 2237, 1655, 1614, 1514, 1420, 1270, 1124, 1046, 997 cm"1; 'HNMR (300 MHz, CDC13) 51.61-1.97 (m, 8 H), 2.23-2.33 (m, 1 H), 2.41-2.48 (m, 1 H), 2.86-2.96 (m, 2 H), 3.14-3.25 (m, 1 H), 3.36 (d, J= 17.4 Hz, 1 H), 4.82-4.89 (m, 1 H), 6.55 (t, J= 75.0 Hz, 1 H), 6.99 (dd, J= 8.1, 2.1 Hz, 1 H), 7.15 (d, J= 2.3 Hz, 1 H), 7.18 (d, J= 8.4 Hz, 1 H), 8.05 (s, 1 H), 12.41 (brs, 1 H). Example 21 6-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazoline-carbonitrile This was prepared as described in example 19 using intermediate 1 (200 mg, 0.538 mmol) and acetamidine hydrochloride (127 mg, 1.343 mmol) in presence of sodium methoxide (100 mg, 1.851 mmol). The product was purified by crystallization from EtOAc-hexane to give 125 mg (61.1 %) of the product as white solid; mp 208-210 °C; IR(KBr) 3432, 2916, 2235, 1651, 1518, 1257, 1147, 1026 cm"1; 'H NMR (300 MHz, DMSO-<4) § 1.62-1.97 (m, 8 H), 2.19-2.29 (m, 1 H), 2.37-2.44 (m, 1 H), 2.45 (s, 3 H), 2.76-2.87 (m, 1 H), 2.86 (d, J= 16.0 Hz, 1 H), 3.05-3.14 (m, 1 H), 3.31 (d, J= 16.8 Hz, 1 H), 3.85 (s, 3 H), 4.78-4.83 (m, 1 H), 6.86 (d, J= 8.4 Hz, 1 H), 6.99-7.03 (m, 2 H), 12.63 (brs, 1 H). 66 Example 22 6-(3-Gyclopentyloxy-4-difluoromethoxyphenyI)-2-methyl-4-oxd-3,4,S,6,7,85 ;; .4 hexahydro-6-quinazolinecarbonitrile F^o CN 0 F J- \#^ 0 Ti NH N CH3 This was prepared as described in example 19 using intermediate 3 (100 mg, 0.245 mmol) and acetamidine hydrochloride (28 mg, 0.296 mmol)) in presence of triethylamine (50 mg, 0.495 mmol). The crude product was purified by crystalization from EtOAc-hexane to give 90 mg (88.2 %) of the product as white solid; mp 188-189 °C; IR (KBr) 2962, 2238, 1647, 1609, 1515, 1420, 1270, 1117, 1044, 852 cm"1; 'H NMR (300 MHz, CDC13) 5 1.65-1.95 (m, 8 H), 2.20-2.43 (m, 2 H), 2.45 (s, 3 H), 2.84 (overlapping d, J= 17.1 Hz, 2 H), 3.00-3.19 (m,l H), 3.32 (d, J= 17.1 Hz, 1 H), 4.80-4.89 (m, 1 H), 6.53 (t, J= 75.3 Hz, 1 H), 6.99 (d, J= 8.4 Hz, 1 H), 7.14-7.18 (m, 2 H), 12.57 (s, 1 H). Example 23 2-Amino-6-(3-Cyclopentyloxy-4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazolinecarbonitrile H3C'°V^ _.. O This was prepared as described in example 19 using intermediate 1 (200 mg, 0.538 mmol) and guanidine hydrochloride (128 mg, 1.339 mmol)) in presence of sodium methoxide (100 mg, 1.851 mmol). The crude product was purified by crystallization from EtOAc-hexane to give 80 mg (39 %) of the product as white solid; mp 310-315 °C; IR (KBr) 3330, 2959, 2236, 1654, 1516, 1267, 1144, 1028 cm-1; 67 'H NMR (300 MHz, DMSO-4) 8 1.55-1.90 (m, 8 H), 2.24-2.46 (m, 3 H),. 2.59-2.68 (m, 1 H), 2.69 (d, J = 16.8 Hz, 1 H), 2.91 (d, J= 16.7 Hz, 1 H), 3.74 (s, 3 H), 4.75-4.85 (m, 1 H), 3.38 (brs, 2 H), 6.94-7.03 (m, 3 H), 10.88 (brs, 1 H) Example 24 2-Amino-6-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazolinecarbonitrile This was prepared as described in example 19 using intermediate 3 (100 mg, 0.245 mmol) and guanidine hydrochloride (59 mg, 0.617 mmol)) in presence of sodium methoxide (45 mg, 0.833 mmol). The crude product was purified by crystallization from EtOAc-hexane to give 45 mg (44 %) of the product as white solid; mp 315-320 °C; IR (KBr) 3331, 3098, 2968, 2347, 1654, 1495, 1170, 1019 cm"1; 'H NMR (300 MHz, DMSO-d6) 5 1.65-1.94 (m, 8 H), 2.23-2.72 (m, 4 H), 2.73 (d, ./ = 15.9 Hz, 1 H), 2.95 (d, J = 15.9 Hz, 1 H), 4.90-4.96 (m, 1 H), 6.31 (brs, 2 H), 7.00 (t, J = 1AA Hz, 1 H), 7.10 (d, J= 8.4 Hz, 1 H), 7.19-7.22 (m, 2 H), 10.87 (brs, 1 H). Example 25 6-(3-CycIopentyIoxy-4-methoxyphenyl)-3-methyl-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazolinecarbonitrile To a well-stirred slurry of compound 19 (150 mg, 0.410 mmol) and cesium carbonate (150 mg, 0.460 mmol) in dry DMF (10 ml), was added iodomethane (76 mg, 0.535 mmol) and the mixture was stirred at room temperature for 1 h under nitrogen. Then reaction was quenched with ice-cold water (100 ml) then extracted with ethyl acetate 68 (100 ml). The organic layer was washed with water (3 x 100 ml), brine (50 ml) and dried (Na2S04). The residue obtained after evaporation of the solvent was purified by silica gel column chromatography using 2 % methanol in chloroform as eluent to give 100 mg (86.3 %) of the product as white solid; mp 59-63 °C; IR (KBr) 2957, 2234, 1661, 1552, 1517, 1417, 1259, 1165, 1027, 1003,770 cm"1; 'H NMR (300 MHz, CDCI3) § 1.63-1.92 (m, 8 H), 2.16-2.26 (m, 1 H), 2.37-2.44 (m, 1 H), 2.79-2.95 (m, 2 H), 3.06-3.15 (m, 1 H), 3.34 (d, J= 17'.7 Hz, 1 H), 3.52 (s, 3 H), 3.85 (s, 3 H), 4.77-4.80 (m, 1 H), 6.85 (d, J = 8.1 Hz, 1 H), 6.97-7.00 (m, 2 H), 8.01 (s, 1 H). Example 26 Ethyl 2-[6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-3-quinazoIinyl]acetate Alkylation reaction was carried out as described in example 25 using of compound 19 (300 mg, 0.820 mmol) with ethyl bromoacetate (151 mg, 0.904 mmol) and cesium carbonate (348 mg, 1.068 mmol) in dry DMF (10 ml) at room temperature. The product was purified by silica gel column chromatography using 40 % EtOAc in chloroform to afford afforded 250 mg (67.4 %) of the product as white solid; mp 55-64 °C; IR(KBr) 2959, 2235, 1749, 1667, 1613, 1518, 1417, 1374, 1258, 1145, 1026 cm"1; 'HNMR(300 MHZ, CDC13) 8 1.31 (t, J= 6.6 Hz, 3 H), 1.61-1.96 (m, 8 H), 2.21-2.27 (m, 1 H), 2.37-2.44 (m, 1 H), 2.80-2.93 (d and m, 2 H), 3.03-3.21 (m, 1 H), 3.33 (d, J= 18.0 Hz, 1 H), 3.84 (s, 3 H), 4.26 (q, J= 7.2 Hz, 2 H), 4.45 (d, J= 17.1 Hz, 1 H), 4.75 (d, J = 17.0 Hz, 1 H), 4.76-4.78 (m, 1 H), 6.84 (d, J= 8.7 Hz, 1 H), 6.96-6.99 (m, 2 H), 7.95 (s, 1H). 69 To a stirred solution of compound 26 (170 mg, 0.376 mmol) in ethanol (5 ml) was added 1.0 N aqueous sodium hydroxide solution (3.0 ml) and the mixture was stirred at room temperature for 4 h. The reaction mixture was diluted with water (20 ml) and washed with 3 x 25 ml diethyl ether. The aqueous layer was acidified with IN aqueous HCl to pH 3 and extracted with ethyl acetate (2 x 50 ml). The combined extracts were washed with water (3 x 50 ml), brine (50 ml) and dried (Na2S04). The residue obtained after evaporation of the solvent was triturated with ether to give 100 mg (62.7 %) of the product as white solid; mp 134-136 °C; IR (KBr) 3444, 2958, 2235, 1736, 1666, 1518, 1418, 1257, 1145, 1026 cm"1; 'H NMR (300 MHz, CDC13) 5 1.61-1.92 (m, 8 H), 2.19-2.25 (m, 1 H), 2.28-2.44 (m, 1 H), 2.80-3.22 (m, 3 H), 3.33 (d,J= 16.0 Hz, 1 H), 3.84 (s, 3 H), 4.55 (d, J= 17.1 Hz, 1 H), 4.74-4.76 (m, 2 H), 5.15 (brs, 1 H), 6.85 (d, J= 8.1 Hz, 1 H), 6.96-6.99 (m, 2 H), 8.20 (s, 1 H) Example 28 Ethyl 2-[6-cyano-6-(3-cyclopentyIoxy-4-methoxyphenyl)-2-methyl-4-oxo-3,4,5,6,7,8- hexahydro-3-quinazolinyl]acetate (28A)& Ethyl 2-[6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyI)-2-methyl-5,6,7,8- tetrahydro-4-quinazolinyloxy]acetate(28B) 70 Alkylation reaction was carried out as described in example 19 using of compound 21 (300 mg, 0.790 mmol) with ethyl bromoacetate (146 mg, 0.874 mmol) and cesium carbonate (310 mg, 0.951 mmol) in dry DMF (10ml) at room temperature. The reaction gives a mixture of N-alkylated and O-alkylated products 28A and 28B respectively. Silica gel column chromatography using 50 % EtOAc in chloroform afforded 70 mg (19 %) of the N-alkylated product 28A as viscous liquid; IR (KBr) 2960, 2235, 1749, 1667, 1555, 1419, 1258, 1024, 777 cm"1; 'HNMR (300 MHz, CDC13) 51.31 (t, J= 6,9 Hz, 3 H), 1.58-1.96 (m, 8 H), 2.19-2.41 (m, 2 H), 2.46 (s, 3 H), 2.71-2.82 (m, 1 H), 2.88 (d, J = 17.4 Hz, 1 H), 3.05-3.16 (m, 1 H), 3.28 (d, J = 17.4 Hz, 1 H), 3.84 (s, 3 H), 4.26 (q, J= 6.9 Hz, 2 H), 4.60 (d, J=17.1 Hz, 1 H), 4.76-4.80 (m, 1 H), 4.95 (d, J= 17.4 Hz, 1 H), 6.84 (d, J= 8.7 Hz, 1 H), 6.96-6.99 (m, 2 H). Further elution with 60 % EtOAc in chloroform afforded 96 mg (26 %) of O-alkylated product 28B as a semisolid, IR (KBr) 2960, 2235, 1749, 1667, 1517, 1419, 1145, 1024,756 cm-1; 'H NMR (300 MHz, CDCI3) 8 1.31 (t, J= 6.9 Hz, 3 H), 1.58-1.96 (m, 8 H), 2.19-2.41 (m, 2 H), 2.46 (s, 3 H), 2.71-2.82 (m, 1 H), 2.88 (d,J= 17.4 Hz, 1 H), 3.05-3.16 (m, 1 H), 3.28 (i,J= 17.4 Hz, 1 H), 3.84 (s, 3 H), 4.23 (q, J= 6.9 Hz, 2 H), 4.79 (d, J= 15.6 Hz, 1 H), 4.77-4.81 (m, 1 H), 5.02 (d,J= 15.6 Hz, 1 H), 6.45 (d, J= 7.8 Hz, 1 H), 6.97- 7.00 (m, 2 H). 71 Example 29 6-(3-Cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-6-quinazolinecarbonitriIe A solution of intermediate 5 (250 mg, 0.678 mmol) and formamidine acetate (100 mg, 0.960 mmol) in dry ethanol (10 ml) was stirred at 70-80 °C for 2 h. The solvent was evaporated under reduced pressure and the residue was diluted with EtOAc (100 ml) and water (100 ml). The layers were separated and the organic layer was washed with water (3 x 50 ml), brine (50 ml), dried (Na2S04) and evaporated. The residue was purified by column chromatography on silica gel using 1 % methanol in chloroform to afford 80 mg (33.7 %) of the product as viscous oil; IR (neat) 3366, 2957, 2233, 1646, 1517, 1239, 754 cm"1; 'H NMR (300 MHz, CDC13) 6 1.60-1.97 (m, 8 H), 2.32-2.71 (m, 2 H), 3.08-3.49 (m, 4 H), 3.86 (s, 3 H), 4.76-4.80 (m, 1 H), 6.87 (d, J= 8.1 Hz, 1 H), 6.86-7.01 (m, 2 H), 8.49 (s, 1 H), 9.03 (s, 1 H). Example 29A 6-(3-Cyclopentyloxy-4-methoxyphenyl)-l-oxo-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile To a stirred solution of compound 29 (100 mg, 0.286 mmol) in chloroform (10 ml) was added 50 % ra-CPBA (250 mg, 0.724 mmol) and the mixture was stirred at room temperature for 5 h. The mixture was diluted with chloroform (50 ml) and washed with \N aqueous sodium hydroxide solution. The chloroform layer was washed with water (2x100 ml), brine (50 ml) and dried (Na2S04). The crude product obtained after evaporation of the solvent was purified by silica gel column chromatography using 1-2 % 72 methanol in chloroform as eluent to give 30 mg of the product as white solid, mp 120- 123 °C; ■'.'■:■.:■' j ■ '/, IR (KBr) 2959, 2236, 1518, 1417, 1382, 1266, 1145 cm"1; lH nmr (300 MHz, CDC13) 5 1.80-1.94 (m, 8 H), 2.28-2.39 (m, 1 H), 2.56-2.63 (m, 1 H), 3.19-3.43 (m, 4 H), 3.87 (s, 3 H), 4.78-4.81 (m, 1 H), 6.89 (d, J= 8.4 Hz, 1 H), 6.95 (dd, J= 8.7, 2.4 Hz, 1 H), 7.01 (d, J= 2.4 Hz, 1 H), 8.06 (s, 1 H), 8.96 (s, 1 H). 'H NMR (300 MHz, CDC13) 5 1.60-1.97 (m, 8 H), 2.32-2.71 (m, 2 H), 3.08-3.49 (m, 4 H), 3.86 (s, 3 H), 4.76-4.80 (m, 1 H), 6.87 (d, J= 8.1 Hz, 1 H), 6.86-7.01 (m, 2 H), 8.49 (s, 1 H), 9.03 (s, 1 H). Example 30 6-(3-Cyclopentyloxy-4-difluoromethoxyphenyI)-5,6,7,8-tetrahydro-6-quinazoline-carbonitrile. This product was prepared as described in example 29 using of intermediate 6 (200 mg, 0.494 mmol) and formamidine acetate (150 mg, 1.44 mmol) to give 20 mg (10.4 %) of the product as viscous oil; 'H NMR (300 MHz, CDCI3) 81.63-1.96 (m, 8 H), 2.33-2.52 (m, 2 H), 3.09-3.40 (m, 4 H), 4.80-4.85 (m, 1 H), 6.54 (t, J= 75.2 Hz, 1 H), 6.97 (dd, 7 = 8.0, 2.1 Hz, 1 H), 7.13 (d, J= 1.8 Hz, 1 H), 7.19 (d, J= 8.4 Hz, 1 H), 8.49 (s, 1 H), 9.04 (s, 1 H). 73 Example 31 6-(3-CycIopentyloxy-4-methoxyphenyl)-2-methyI-5,6,7,8-tetrahydro-6-nuinaznlinecarhonitrile This product was prepared as described in example 29 using of intermediate 5 (100 mg, 0.271 mmol), acetamidine hydrochloride (31 mg, 0.327 mmol) and sodium methoxide (18 mg, 0.333 mmol) in methanol (10 ml) at 60-70 °C for 10 h. The product was purified by silica gel column chromatography using 2 % methanol in chloroform to afford afforded 80 mg (81.1 %) of the product as white solid; mp 133-136 °C; IR(KBr) 3430, 2953, 2233, 1583, 1517,1 443, 1246, 802 cm"1; 'H NMR (300 MHz, CDC13) 8 1.60-1.99 (m, 8 H), 2.31-2.55 (m, 2 H), 2.71 (s, 3 H), 3.01-3.36 (m, 4 H), 3.86 (s, 3 H), 4.75-4.79 (m, 1 H), 6.87 (d, J= 9.0 Hz, 1 H), 6.97-7.02 (m, 2 H), 8.04 (s, 1 H). Example 32 2-Amino-6-(3-cyclopentyIoxy-4-methoxyphenyI)-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile This product was prepared as described in example 29 using of intermediate 5 (200 mg, 0.542 mmol), guanidine hydrochloride (68 mg, 0.711 mmol) and sodium ethoxide (50 mg, 0.734 mmol) in ethanol (10 ml) at 70-80 °C for 1 h. The mixture was cooled to room temperature and the solid precipitated was collected by filtration. The crude product was crystallized from ethanol to give 167 mg (85 %) of the product as white solid, mp 215-219 °C; IR (KBr) 3316, 3163, 2957, 2237, 1667, 1523, 1276, 1144 cm "'; 74 'H NMR (300 MHz, CDCI3) 5 1.59-1.97 (m, 8 H), 2.26-2.46 (m, 2 H), 2.82-2.90 (m, 1 H), 3.01-3.23 (m, 3 H), 3.85 (s, 3 H), 4.76-4.79 (m, 1 H), 4.95 (brs, 2 H), 6^5 (d, J= 8.4 Hz, 1 H), 6.96 (dd, J- 8.4, 2.1 Hz, 1 H), 7.01 (s, 1 H), 8.06 (s, 1 H); m/z 365 (MH+, 100 %),297(40). Example 33 2-Amino-6-(3-cyclopentyloxy-4-difluoromethoxyphenyl)-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile This product was prepared as described in example 29 using of intermediate 6 (200 mg, 0.494 mmol), guanidine hydrochloride (63 mg, 0.659 mmol) and sodium methoxide (36 mg, 0.666 mmol) in methanol (10 ml) at 70-80 °C for 1 h. The mixture was cooled to room temperature and the solid precipitated was collected by filtration. The crude product was crystallized from ethanol to give 110 mg (61 %) of the product as white solid, mp 123-126 °C; IR(KBr)3323, 3179, 2961,2235, 1600, 1514, 1269, 1127, 1047 cm"1; 'H NMR (300 MHz, CDC13) 8 1.76-1.97 (m, 8 H), 2.27-2.49 (m, 2 H), 2.85-2.95 (m, 1 H), 3.05-3.26 (m, 3 H), 4.82-4.86 (m, 1 H), 5.01 (brs, 2 H), 6.55 (t, J= 75.0 Hz, 1 H), 6.98 (dd, J= 8.7, 2.4 Hz, 1 H), 7.14 (d, J = 2.1 Hz, 1 H), 7.19 (d, J= 8.7 Hz, 1 H), 8.08 (s, 1 H). 75 Example 34 M-[6-Cyano-6-(3-Cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-2-quinazolinyl]-acetamide To a stirred' solution of compound 32 (100 mg, 0.274 mmoi) and trietnyiami'ne ($6 mg, 0.851 mmol) in dichlorornethane (10 ml) was added acetyl chloride (42 mg, 0.535 mmol) and the mixture was refluxed for 3 h. The reaction mixture was cooled to room temperature and diluted with 100 ml dichlorornethane. The dichlorornethane solution was washed with water (3 x 50 ml), brine (50 ml) and dried (Na2S04). The residue obtained after evaporation of the solvent was purified by chromatography on silica gel using 2 % methanol in chloroform to give* 30 mg (26.8 %) of the product as white solid, mp 105-108 °C; IR (KBr) 3427, 2958, 2233, 1727, 1561, 1580, 1419, 1369, 1255, 1147, 1027 cm'1; 'H NMR (300 MHz, CDC13) 5 1.58-1.90 (m, 8 H), 2.31 (s, 3 H), 2.36-2.52 (m, 2 H), 3.15-3.46 (m, 4 H), 3.86 (s, 3 H), 4.75-4.85 (m, 1 H), 6.89 (d, J= 8.4 Hz, 1 H), 6.98-7.02 (m, 2 H), 8.58 (s, 1 H) Example 35 2-[6-Cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-2-quinazolinylamino]-acetic acid. This product was prepared as described in example 29 using intermediate 5 (100 mg, 0.271 mmol), guanidine acetic acid (32 mg, 0.35 mmol) and sodium methoxide (55 mg, 1.018 mmol) in methanol (10 ml) at 60-70 °C for 8 h. The product was extracted into EtOAc after acidifying the mixture with 0.1 N aqueous HCl to pH 2. The crude product 76 was crystallised from hexane to give 60 mg (52.3 %) of the product as off-white solid; mp 85-90 °C; ■; , , . IR (KBr) 3306, 2951, 2234, 1724, 1602, 1517, 1471, 1257, 1144, 1021 cm*1; - ; > ■;, "H NMR (300 MHz, CDC13) 8 1.61-1.98 (m, 8 H), 2.30-2.51 (m, 2 H), 2.58-3.28 (m, 4 H), 3.81 (s, 3 H), 2.26 (d, J= 3.3 Hz, 2 H), 4.80 (d, J= 3.3 Hz, 1 H), 6.87 (d, J- 8.4 Hz, 1 H), 6.97-7.02 (m, 2 H), 8.00 (brs, 1 H), 8.09 (s, 1 H). Example 36 2-Methylthio-6-(3-cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-6-quinazoline-carbonitrile This product was prepared as described in example 29 using intermediate 5 (500 mg, 1.356 mmol), S-methylthiouranium sulphate (454 mg, 1.6 mmol) and sodium methoxide (88 mg, 1.629mmol) in methanol (20 ml) at 60-70 °C for 3 h. The crude product was purified by chromatography on silica gel using 2 % methanol in chloroform to give 250 mg (46.5%) of the product as white solid; mp 125-128 °C; IR (KBr) 3433, 2963, 2238, 1573, 1541, 1412, 1229, 1143, 803 cm"l; 'HNMR (300 MHz, CDC13) 6 1.57-1.99 (m, 8 H), 2.29-2.54 (m, 2 H), 3.09 (s, 3 H), 3.02-3.31 (m, 4 H), 3.85 (s, 3 H), 4.74-4.80 (m, 1 H), 6.85 (d, J= 8.5 Hz, 1 H), 6.94-7.03 (m, 2 H), 8.27 (s, 1 H). 77 Example 37 2-MethanesuIfonyl-6-(3-cyclopentyIoxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-6-quinazoline-carbonitrile H3C'°- To a stirred and cooled (0 °C) solution of compound 36 (100 mg, 0.252 mmoi) in dichloromethane (25 ml) was added m-CPBA (173 mg, 1.002 mmol) and the mixture was stirred at the same temperature for 2 h. The mixture was treated with 10 % aqueous Na2S03 solution (5 ml) and filtered. The filtrate containing the product was washed with 10 % aqueous NaHC03 solution (2 x 25 ml), water (25 ml) and brine (25 ml) and dried. The crude product obtained after evaporation of the solvent was purified by chromatography on silica gel to give 40 mg (37 %) of the product as white solid; mp 75-78 °C; IR (KBr) 3436, 2960, 2235, 2186, 1714, 1518, 1315, 1145, 778 cm'1; 'HNMR (300 MHz, CDC13) 8 1.56-1.99 (m, 8 H), 2.34-2.61 (m, 2 H), 3.17-3.49 (m, 4 H), 3.34 (s, 3 H), 3.85 (s, 3 H), 4.75-4.79 (m, 1 H), 6.85 (d, J= 8.7 Hz, 1 H), 6.92-7.00 (m, 2 H), 8.63 (s, 1 H). Freshly distilled phosphorus oxychloride (10 ml) was added to compound 19 (200 mg, 0.547 mmol) and the mixture is stirred at 105-110 °C for 30 min under nitrogen. Excess POCI3 was removed under reduced pressure then dried under high vacuum to give 250 mg of 6-(3-Cyclopentyloxy-4-methoxyphenyl)-4-chloro-5,6,7,8-tetrahydro-6-quinazo-linecarbonitrile as a brown residue. This above residue was dissolved in methanol (5 ml) 78 and treated with potassium methoxide (115 mg, 1.639 mmol) and stirred at room temperature for 1 h. The reaction mixture was diluted with EtOAc (100 ml), washed with water (3 x 100 ml), brine (50 ml) and dried (Na2S04). The residue obtained after evaporation of the solvent was purified by chromatography on silica gel using 20 % EtOAc in chloroform to give 40 mg (19 %) of the product as a low-melting solid; IR (KBr) 3415, 2957, 2235,1708, 1580, 1469, 1258, 1014 cm"1; 'H NMR (300 MHz, CDC13) 5 1.59-1.66 (m, 2 H), 1.77-1.98 (m, 6 H), 2.27-2.48 (m, 2 H), 2.96-3.05 (m, 1 H), 2.98 (d, J= 18.4 Hz, 1 H), 3.21-3.30 (m, 1 H), 3.34 (d, J= 18.6 Hz, 1 H), 3.86 (s, 3 H), 4.01 (s, 3 H), 4.75-4.81 (m, 1 H), 6.88 (d, J= 8.4 Hz, 1 H), 6.97-7.03 (m, 2 H), 8.62 (s, 1 H). Example 39 6-(3-Cydopentytoxy-4-methoxyphenyI)-4-methyfomino-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile Freshly distilled phosphorus oxychloride (10 ml) was added to compound 19 (200 mg, 0.547 mmol) and the mixture is stirred at 105-110 °C for 30 min under nitrogen. Excess POCI3 was removed under reduced pressure then dried under high vacuum to give 250 mg of 6-(3-Cyclopentyloxy-4-methoxyphenyl)-4-chIoro-5,6,7,8-tetrahydro-6-quinazo-line-carbonitrile as a brown residue. This intermediate was used as such for the next step without further purification. The above residue was treated with ethanolic methyl amine solution (8 ml, 15 %) and the mixture was stirred at 10-15 °C for 2 h. The mixture was diluted with water (200 ml), extracted with ethyl acetate (2 x 50 ml), washed with water (3 x 50 ml), brine (30 ml) and dried (NaaSO^. The residue obtained after evaporation of the solvent was purified by chromatography on silica gel using 2 % methanol in chloroform as eluent to give 50 mg (24.1 %) of the product as white solid, mp 149-152 °C; IR (KBr) 3378, 2958, 2234, 1591, 1518, 1387, 1264, 1146, 1034,805 cm"1; 79 'HNMR(300 MHZ, CDC13) 5 1.58-1.95 (m, 8 H), 2.25-2.42 (m, 2 H),2.77 (d,J= 16.5 H, 1 H), 2.86-2.89 (m, 1 H), 2.93 (d,J= 16.2 Hz, 1 H), 3.10-3.18{m, 1 H), 3.04 (d, 4.8 Hz, 3 H), 3.10-3.18 (m, 1 H), 3.84 (s, 3 H), 4.55 (brs, 1 H), 4.73-4,77 (m, 1 H), 6.84 (d, J = 8.4 Hz, 1 H,), 6.94-6.97 (m, 2 H), 8.49 (s, 1 H). Example 40 6-(3-Cyclopentyloxy-4-methoxyphenyI)-4-dimethyIamino-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile The 4- chloro derivative was prepared as example 39 from pyrimidinone 19 (200 mg, 0.547 mmol) was treated with dimethylamine (54 mg, 1.20 mmol) in methanol (10 ml) and the mixture was stirred at room temperature for 6 h. Work-up and purification of the as described in example 24 gave 105 mg (48.8 %) of the product as off-white solid, mp 52-57 °C; IR (KBr) 3363, 2928, 2233, 1746, 1571, 1398, 1144, 1022 cm'1; 'H NMR (300 MHz, CDCb) 5 1.75-1.98 (m, 8.H), 2.35-2.47 (m, 2 H), 2.92-3.06 (m, 2 H), 3.01 (s, 6 H), 3.10-3.25 (m, 2 H), 3.85 (s, 3 H), 4.70-4.75 (m, 1 H), 6.85 (d, J= 8.4 Hz, 1 H), 6.90-7.00 (m, 2 H), 8.51 (s, 1 H). 80 Example 41 4-«-Butylamino-6-(3-cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrah^dro-6- quinazolinecarbonitrile ' '"''_■'■ H3C'°- The 4-chloro derivative was prepared as example 39 from pyrimidinone 19 (200 mg, 0.547 mmol) was treated with «-butylamine (400 mg, 5.479 mmol) in ethanol (10 ml) and the mixture was stirred at room temperature for 18 h. Work-up and purification of the crude material by chromatography on silica gel using 30 % ethyl acetate in chloroform gave 75 mg (32.5 %) of the product as off-white solid; mp 122-128 °C; IR (KBr) 3398, 2959, 2230, 1590, 1518, 1414, 1256, 1146, 1024,774 cm"1; 'H NMR (300 MHz, CDC13) 6 0.95 (t, J= 7.2 Hz, 3 H), 1.40 (q, J= 8.1 Hz, 2 H), 1.55-1.67 (m, 4 H), 1.76-1.95 (m, 6 H), 2.26-2.43 (m, 2 H), 2.85 (dd, J= 17.1, 5.8 Hz, 2 H), 2.82-2.87 (m, 1 H), 3.10-3.22 (m, 1 H), 3.46-3.53 (m, 2 H), 3.85 (s, 3 H), 4.41 (t, J = 5.1 Hz, 1 H), 4.74-4.78 (m, 1 H), 6.86 (d, J= 8.4 Hz, 1 H), 6.97-7.00 (m, 2 H), 8.47 (s, 1 H). Example 42 6-(3-Cydopentyloxy-4-methoxyphenyl)-4-morphoIino-5,6,7,8-tetrahydro-6-quinazoline-carbonitrile The 4- chloro derivative was prepared as described in example 39 from pyrimidinone 19 (150 mg, 0.410 mmol) was treated with morpholine (5.0 ml) and the mixture was stirred at room temperature for 4 h. Work-up and purification of the crude material by chromatography on silica gel using 2 % methanol in chloroform gave 110 mg (61.6 %) of the product as off-white solid; mp 55-59 °C; 81 IR(KBr)2959, 1566, 1518, 1427, 1258,1116,105,995,855 cm'1; 'H NMR (300 MHz, CDC13) 6 1.59-1.93 (m, 8 H), 2.36-2.54 (m.i H), 2.95-3.01 (m, 4 H), 3.25-3.42 (m, 4 H), 3.74-3.83 (m, 4 H), 3.85 (s, 3 H), 4.72-4.75 (m, 1 H), 6.86 (d, J-8.4 Hz, 1 H), 6.88-6.97 (m, 2 H), 8.16 (s, 1 H). Example 43 6-(3-Cyclopentyloxy-4-methoxyphenyI)-4-phenyIamino-5,6,7,8,-tetrahydro-6-quinazolinecarbonitile The 4- chloro derivative was prepared as described in example 39 from pyrimidinone 19 (150 mg, 0.410 mmol) was treated with aniline (382 mg, 4.107 mmol) and the mixture was stirred at room temperature for 18 h. Work-up and purification of the crude material by chromatography on silica gel using 15 % EtOAc in chloroform gave 30 mg (16.5 %) of the product as off-white solid; mp 192-198 °C; IR (KBr) 3381, 2962, 2236, 1607, 1574, 1517, 1443, 1256, 1146, 1016, 752 cm"1; 'HNMR (300 MHz, CDCI3) 81.66-1.96 (m, 8 H), 2.34-2.45 (m, 2 H), 2.93-3.26 (m, 4 H), 3.86 (s, 3 H), 4.76-4.78 (m, 1 H), 6.27 (brs, 1 H), 6.88 (d, J= 8.4 Hz, 1 H), 7.01-7.03 (m, 2 H), 7.12 (t, J= 7.5 Hz, 1 H), 7.35 (t, J= 7.5 Hz, 2 H), 7.53 (d, J- 7.8 Hz, 2 H), 8.57 (s, 1H). 82 Example 44 4-Benzylamino-6-(3-cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile The 4-chloro derivative was prepared as described in example 39 from pyrimidinone 19 (250 mg, 0.684 mmol) was treated with benzylamine (1.3 g, 12.149 mmol) and the mixture was stirred 80-90 °C for 18 h. Work-up and purification of the crude material by chromatography on silica gel using 15 % EtOAc in chloroform gave 100 mg (32.1 %) of the product as off-white solid; mp 65-70 °C; IR (KBr) 3391, 2957, 1590, 1517, 1453, 1355, 1259, 1146, 1022, 700 cm-1; *H NMR (300 MHz, CDC13) 81.68-2.04 (m, 8 H), 2.39-2.59 (m, 2 H), 2.86-3.07 (m, 3 H), 3.26-3.39 (m, 1 H), 3.84 (s, 3 H), 4.80 (s, 2 H), 4.82-4.98 (m, 2 H), 6.64 (d, J= 8.4 Hz, 1 H), 7.05-7.08 (m, 2 H), 7.38-7.45 (m, 5 H), 8.65 (s, 1 H). Example 45 6-(3-Cyclopentyloxy-4-methoxyphenyI)-4-phenethylamino-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile The 4-chloro derivative was prepared as described in example 39 from pyrimidinone 19 (150 mg, 0.410 mmol) was treated with 2-phenylethylamine (1.0 g, 8.264 mmol) and the mixture was refluxed at 80-90 °C for 18 h. Work-up and purification of the crude material 83 by chromatography on silica gel using 25 % EtOAc in chloroform gave/;60 mg (39.6 %) of the product as off-white solid; mp 110-120 °C; " -'-■'■■•'? ., IR (KBr) 3283, 1961, 2237, 1595, 1518, 1262, 1023, 701 cm-1; 'H NMR (300 MHz, CDC13) 5 1.62-1.95 (m, 8 H), 2.23-2.43 (m, 2 H), 2.62-2.95 (m, 5 H), 3.10-3.21 (m, 1 H), 3.70-3.85 (m, 2 H), 3.84 (s, 3 H), 4.49 (brs, 1 H), 4.72-4.78 (m, 1 H), 6.83-6.94 (m, 3 H), 7.15-7.32 (m, 5 H), 8.50 (s, 1 H). The present invention provides a novel series of heterocyclic compounds having potential therapeutic activity and medical use against several allergic disorders, particularly in asthma. In vitro Studies Inhibition of Phosphodiesterase Enzymes (PDE4) In this assay, PDE4 enzyme converts [3H] cAMP to the corresponding [3H] 5'-AMP in proportion to the amount of PDE4 present. The [3H] 5'-AMP then was quantitatively converted to free [3H] adenosine and phosphate by the action of snake venom 5'-nucleotidase. Hence, the amount of [3H] adenosine liberated is proportional to PDE4 activity. The assay was performed with modification of the method of Thompson and Appleman (Biochemistry; 1971; 10; 311-316) and Schwartz and Passoneau (Proc. Natl. Acad. Sci. U.S.A. 1974; 71; 3844-3848), both references incorporated herein by reference in their entirety, at 34°C. In a 200 :1 total reaction mixture, the reaction mixture contained 12.5mM of Tris, 5 mM MgCl2, 1:M cAMP (cold) and 3H cAMP (0.1 :Ci), (Amersham). Stock solutions of the compounds to be investigated were prepared in DMSO in concentrations such that the DMSO content in the test samples did not exceed 0.05 % by volume to avoid affecting the PDE4 activity. Drug samples were then added in the reaction mixture (25 :l/tube). The assay was initiated by addition of enzyme mix (75 :L) and the mixture was incubated for 20 minutes at 34° C. Then the reaction was stopped by boiling the tubes for 2 mins at 100°C in a water bath. After cooling on ice for 5 minutes and addition of 50 ug/reaction of 5'-nucleotidase snake venom from Crotalus 84 atrox incubation was carried out again for 20 min. at 34°C. The unreacted substrate was separated from (3H) Adenosine by addition of Dowex AG 1X-8 ( Biorad Lab), (400 ul) which was prequilibrated (1:1:1) in water and ethanol. Reaction mixture was then thoroughly mixed, placed on ice for 15 minutes, vortexed and centrifuged at 14,000 r.p.m. for 2 mins. After centrifugation, a sample of the supernatant was taken and added in 24 well optiplates containing Scintillant (1 ml) and mixed well. The samples in the plates were then determined for radioactivity in a Top Counter and the PDE4 activity was calculated. PDE4 enzyme was present in quantities that yield <30% total hydrolysis of substrate (linear assay conditions). Additionally, activity of the compounds were tested against other Phosphodiesterase enzymes, namely, PDEl(Ca.sup.2+/calmodulin-dependent), PDE2(cGP-stimulated), PDE3 (cGP-inhibited), PDE5 (cGP-specific) and PDE6 (cGP-specific, photoreceptor). Results were expressed as percent inhibition (ICso) in nM concentrations. The IC50 values were determined from the concentration curves by nonlinear regression analysis. 85 Example No. IC50(in nM) 1 62.24 2 14.86 4 11.49 7 >lnM 9 85.89 11 123.23 12 176 13 143.5 14 20.1 15 134.6 19 92.18 20 33.78 25 656.2 26 577.2 27 594.2 28B 439.20 29 21.21 30 3.13 31 948.4 32 17.92 33 21.69 35 775.9 36 luM 37 1 \M 38 267.4 40 136.2 45 232.9 86 We Claim: 1. A compound of the general formula (I) wherein, R1 is independently selected for each occurrence from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstitued alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylakyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heterocyclic group, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted heteroarylalkyl, -C(0)-R', -CCOJO-R1, -C(0)NR1R1 and -S(0)m-R]; wherein P is selected from the group consisting of bond, oxygen, sulfur and NR1; wherein P1 is selected from the group consisting of hydrogen, halogen atom , -OR , -S(0)m R1, -C(0)R1 , formyl amine, nitro and -NRxRy wherein Rx and Ry are independently selected from the group consisting of hydrogen substituted or unsubstituted alkyl, haloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heterocyclylalkyl, and substituted or unsubstituted heteroarylalkyl; m is 0,1 or 2 87 R2 is selected from the group consisting of hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, CN, -GH=CR R , - c =c (R3), CH2NHC(0)C(0)NH2, (0)R3,CH20R3, NR3R4, N02, CH2NR3R4, C(Z)H, C(0)OR3, and C(0)NR3R4; Z is selected from the group consisting of O, NR5, NOR3, NCN, C(-CN)2, CR3CN, CR3N02, CR3C(0)OR3, CR3C(0)NR3R3, C(-CN)N02, C(-CN)C(0)0R5, and C(- CN)C(0)NR3R3 R4 is selected from the group consisting of OR and R ; R3 is selected from the group consisting of hydrogen or substituted or unsubstituted alkyl, and halogen; R5 is selected from the group consisting of hydrogen, and substituted unsubstituted alkyl; The ring 'A' is selected from the group consisting of substituted or unsubstituted aryl ring, and optionally substituted saturated or unsaturated five to seven membered heterocyclic ring containing one or more heteroatoms selected from the group consisting ofO, SandNR1; and their analogs, their tautomers, their regioisomers, their diasteromers, their stereoisomers, their geometrical isomers, their N-oxides, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutical^ acceptable solvates thereof. 2. The compound according to claim 1 wherein the substituents in the 'substituted alkyl', 'substituted alkoxy' 'substituted alkenyP 'substituted alkynyl' 'substituted cycloalkyl' substituted cycloalkylalkyl' substituted cyclocalkenyP 'substituted arylalkyl' 'substituted aryl' 'substituted heterocyclic ring', 'substituted heteroaryl alkyl', 'substituted heterocyclylalkyl ring', 'substituted amino', 'substituted alkoxycarbonyP, 'substituted cyclic ring' 'substituted alkylcarbonyl', 'substituted alkylcarbonyloxy' and 'substituted carboxylic acid' may be the same or different which one or more selected from the group consisting of hydrogen, hydroxy, halogen, carboxyl, cyano, amino, nitro, oxo (=0), thio (=S), or optionally substituted groups selected from alkyl, alkoxy, alkenyl, alkynyl, aryl, arylalkyl, cycloalkyl, aryl, heteroaryl, heteroarylalkyl, heterocyclic ring, -C00Rx, -C(0)Rx, -C(S)Rx, -C(0)NRxRy, -C(0)ONRxRy, -NRxCONRyRz, -N(Rx)SORy, -N(Rx)S02Ry, -(=N-N(Rx)Ry), - NRxC(0)0Ry, -NRxRy, -NRxC(0)Ry-, -NRxC(S)Ry - 88 NRxC(S)NRyRz, -SONRxRy-, -S02NRxRy-, -ORx, -ORxC(0)^RyRz, ^QRxCp)ORy-, -OC(0)Rx, -OC(0)NRxRy, -RxNRyRz, -RxRyRz, -RXCF3, -RxNRyC(0)Rz, -R^ORy, -RxC(0)ORy, -RxC(0)NRyRz, -RxC(0)Rx, -RxOC(0)Ry, -SRx, -SORx, -S02Rx, and -ONO2, wherein Rx, Ry and Rz are independently chosen from the group consisting of hydrogen atom, substituted or unsubstituted alkyl, haloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl substituted or unsubstitued heterocyclic ring, substituted or unsubstitued heterocyclylalkyl, substituted or unsubstitued heteroaryl and substituted or unsubstitued heteroarylalkyl. 3. The compound according to claim 1 wherein R2 is cyano. 4. The compound according to claims 1,2 or3 wherein A is chosen from the group consisting of 89 wherein R6, R7 and R8 are independently chosen from the group consisting of hydrogen, hydroxy, halogen, cyano, nitro, formyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted heterocyclylalkyl ring, substituted or unsubstituted amino, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted cyclic ring, substituted or unsubstituted alkylcarbonyl, 'substituted or unsubstituted alkylcarbonyloxy, substituted or unsubstituted carboxylic acid and S(0)mR6; 90 R9 and R10 are independently selected from the group consisting of hydrogen, hydroxy, halogen, nitro, cyano, formyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted heterocyclylalkyl ring, substituted or unsubstituted amino, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted cyclic ring, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkylcarbonyloxy, and substituted or unsubstituted carboxylic acid; or R9 and R10 may be joined to a form a optionally substituted saturated or unsaturated cyclic ring, which may optionally include up to two heteroatoms selected from the group consisting of O, NR6 and S; and R", R12, and R13 are independently selected from the group consisting of hydrogen, hydroxy, halogen, cyano, nitro, formyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted heterocyclylalkyl ring, substituted or unsubstituted amino, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted cyclic ring, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkylcarbonyloxy, substituted or unsubstituted carboxylic acid and S(0)mR6; m is 0,1 or 2. 5. The compound according to claims 1,2 3,or 4 wherein A is chosen from the group consisting of 91 6. The compound according to claims 1,2,3,4, or 5 wherein P1 is unsubstituted or substituted alkoxy. 7. The compound according to claims 1,2,3,4,5, or 6 wherein P1 is .,0, 8. The compound according to claims 1,2,3,4,5,6 or 7 wherein P is O. 9. The compound according to claims 1,2,3,4,5,6, 7 or 8 wherein R1 is unsubstituted cycloalkyl. 10. The compound according to claim 1,2,3,4,5,6,7,8, or 9 wherein R1 is cyclopentyl. 11. The compound according to claim 1; 5-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-3-oxo-2,3,4,5,6,7-hexahydro-l//-indazole-5-carbonitrile. 12. The compound according to claim 1; 5-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-4,5,6,7-tetrahydro-lJ:/-5-indazolecarbonitrile. 13. The compound according to claim 1; 5-(3-Cyclopentyloxy-4-methoxyphenyl)-4,5,6,7-tetrahydro-177-5-indole-carbonitrile. 92 14. The compound according to claim 1; 6-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-5,6,7,8-tetrahydro-6-quinazoline-carbonitfile. 15. The compound according to claim 1 selected from the group consisting of. ... 5-(3-Cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5,6,7-hexahydro-l//-indazole-5-carbonitrile; 5-(3~Cyclopentyloxy-4-methoxyphenyl)-4,5,6,7-tetrahydro-l//-5-indazole-carbonitrile; 5-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-2-phenyl-4,5,6,7-tetrahydro-2//-indazole-5-carbonitrile; 5-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-l-phenyl-4,5,6,7-tetrahydro-2H-indazole-5-carbonitrile; 5-(3-Cyclopentyloxy-4-methoxyphenyl)-2-(2-pyidyl)-4,5,6,7-tetrahydro-2//'-5-indazole-carbonitrile; 5-(3-Cyclopentyloxy-4-methoxyphenyl)-l-methyl-4,5,6,7-tetrahydro-l//-5-indazolecarbonitrile; 5-(3-Cyclopentyloxy-4-methoxyphenyl)-l-methyl-4,5,6,7-tetrahydro-2//-5-indazolecarbonitrile; 2-[5~Cyano-5-(3-Cyclopentyloxy-4-methoxyphenyl)-4,5,6,7-tetrahydro-l//-l-indazoyl] acetic acid; 2-[5-Cyano-5-(3-Cyclopentyloxy-4-methoxyphenyl)-4,5,6,7-tetrahydro-2i/-l-indazoyl] acetic acid; 5-(3-Cyclopentyloxy-4-methoxyphenyl)-4,5,6,7-tetrahydrobenzo[c]isoxazole-5-carbonitrile; 93 5-(3-Cyclopentyloxy-4-methoxyphenyl)-3-methyl-2-oxo-23,4,5;j6,7-he^ahydro- benzo[c/][l,3]oxazole-5-carbonitrile; \' -/'*•.-.. \\ ■: ' . ^% 5-(3-Cyclopentyloxy-4-methoxyphenyl)4-vinyl4,5,67-tetrahydro-lW-5-indoiA- s carbonitrile; " • ' 5-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-l-vinyl-4,5,6,7-tetrahydro-li/-5-indolecarbonitrile; 5-(3-CyclopentyIoxy-4-difluoromethoxyphenyl)-4,5,6,7-tetrahydro-l/f-5-indazole-carbonitrile; 5-(3-Cyclopentyloxy-4-methoxyphenyl)-l-methyl-4,5,6,7-tetrahydro-li/-5-indole-carbonitrile; Ethyl 6-Cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-2-methyl-5,6,7,8-tetrahydro-3-quinolinecarboxylate; 6-Cyano-6-(3-cyclopentyloxy~4-methoxyphenyl)-2-methyl-5,6,7,8-tetrahydro-3-quinolinecarboxylic acid; 6-(3-Cyclopentyloxy-4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazoline-carbonitrile; 6-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazolinecarbonitrile; 6-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazoline-carbonitrile; 6-(3-Cyclopentyloxy-4-difluoromethoxyphenyI)-2-methyl-4-oxo-3,4,5,6,7,8-hexahydro-6-quinazofi'necarbonitn'Ie; 94 2-Amino-6-(3-Cyelopentyloxy-4-methoxyphenyl)-4-oxo-3,4,5,6,7,84iexahydro-6- quinazolinecarbonitrile; 2-Amino-6-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-4-oxo-3,4,5:,6,7,8- .,. hexahydro-6-quinazolinecarbonitrile; e-CS-Cyclopentyloxy^-methoxyphenyO^-methyl^-oxo-S^^^J^-hexahydro-e-quinazolinecarbonitrile; Ethyl 2-[6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-3-quinazolinyl]acetate; 2-[6-Cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro-3-quinazolinyl]acetic acid.; Ethyl 2-[6-cyano-6-(3-cycIopentyloxy-4-methoxyphenyl)-2-methyl-4-oxo-3,4,5,6,7,8-hexahydro-3-quinazolinyl]acetate; Ethyl 2-[6-cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-2-methyI-5,6,7,8-tetrahydro-4-quinazolinyloxy]acetate; 6-(3-Cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile; 6-(3-Cyclopentyloxy-4-methoxyphenyl)-l-oxo-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile; 6-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-5,6,7,8-tetrahydro-6-quinazoline-carbonitrile; 2-Amino-6-(3-cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile; 2-Amino-6-(3-cyclopentyloxy-4-difluoromethoxyphenyl)-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile; 95 A^l-[6-Cyano-6-(3-Cyclopentyloxy-4-metnoxypnenyl)-5,6,7,8-tetrahydroT2' quinazolinyl]-acetamide; ^ 2-[6-Cyano-6-(3-cyclopentyloxy-4-methoxyphenyl)-5,6,7,8itetrahydro-2-quinazolinylamino]-acetic acid; 2-Methylthio-6-(3-cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-6-quinazoline-carbonitrile; 2-Methanesulfonyl-6-(3-cyclopentyloxy-4-methoxyphenyI)-5,6,7,8-tetrahydro-6-quinazoline-carbonitrile; 6-(3-Cyclopentyloxy-4-methoxyphenyl)-4-methoxy-5,6,7,8-tetrahydro-6-quinazoline-carbonitrile; 6-(3-Cyclopentyloxy-4-methoxyphenyl)-4-methylamino-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile; 6-(3-Cyclopentyloxy-4-methoxyphenyl)-4-dimethylamino-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile; 4-«-Butylamino-6-(3-cycIopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile; 6-(3~Cyclopentyloxy-4-methoxyphenyl)-4-moq)holmo-5,6,7,8-tetrahydro-6-quinazoline-carbonitrile; 6-(3-Cyclopentyloxy-4-methoxyphenyI)-4-phenylamino-5,6,7,8,-tetrahydro-6-quinazolinecarbonitile; 4-Benzylamino-6-(3-cyclopentyloxy-4-methoxyphenyl)-5,6,7,8-tetrahydro-6-quinazolinecarbonitrile; and 96 6-(3-Cyclopentyloxy-4-methoxyphenyl)-4-phenethylamino-5,6,7,5--tetrahydro-6- quinazolinecarbonitrile. $■■ ■ '■ ':"' 16. A process for the preparation of a compound of the general formula 1A wherein R1 is chosen independently selected for each occurrence from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstitued alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylakyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heterocyclic group, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted heteroarylalkyl , -C(0)-R\ -C(0)0-R\ -C(0)NR1RI and -SCOVR1; wherein P is selected from the group consisting of bond, oxygen, sulfur and NR1; wherein P1 is selected from the group consisting of hydrogen, halogen atom , -OR1 , -S(0)m R1, -C(0)R' , formyl amine, nitro and -NRxRy wherein RX and Ry are independently selected from the group consisting of hydrogen substituted or unsubstituted alkyl, haloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heteroarylalkyl; m is 0,1 or 2 97 R2 is selected from the group consisting of hydrogen, halogen, substituted or 3r,3 unsubstituted alkyl, substituted or unsubstituted cycloalkyl, CN, -CH=CR R >3T>4 - c =c (R^ CH2NHC(0)C(0)NH2, (0)R3,CH2ORj, NR3R4, N02, CH2NRJR\ C(Z)H, C(0)OR3, and C(0)NR3R4; Z is selected from the group consisting of O, NR5, NOR3, NCN, C(-CN)2, CR3CN, CR3N02, CR3C(0)OR3, CR3C(0)NR3R3, C(-CN)N02, C(-CN)C(0)0R5, and C(-CN)C(0)NR3R3; R4 is selected from the group consisting of OR3 and R5; R3 is selected from the group consisting of hydrogen or substituted or unsubstituted alkyl, and halogen; R5 is selected from the group consisting of hydrogen, and substituted unsubstituted alkyl; comprising reacting a compound of the formula 9 p' (9) wherein P1, R1, R2 and P have the meanings as described above with hydrazine in a solvent at a temperature of about 25°C to about 200°C. 17. The process according to claim 16 wherein said solvent is an alcoholic solvent. 18. The process according to claim 17 wherein said alcoholic solvent is methanol. 19. The process according to claim 18 wherein the reaction is conducted at a temperature of about 65°C. 20. A process for the preparation of a compound of the general formula IE 98 R6 (IE) wherein R1 is chosen independently selected for each occurrence from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstitued alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylakyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heterocyclic group, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted heteroarylalkyl , -C(0)-R', -C(0)0-R', -C(0)NR'R' and -S(0)m-R'; wherein P is selected from the group consisting of bond, oxygen, sulfur and NR ; wherein P1 is selected from the group consisting of hydrogen, halogen atom , -OR , -S(0)m R1, -C(0)R' , formyl amine, nitro and -NRxRy wherein RX and Ry are independently selected from the group consisting of hydrogen substituted or unsubstituted alkyl, haloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heteroarylalkyl; m is 0,1 or 2 R is selected from the group consisting of hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, CN, -CH=CR3R3, - c ^c (R3)? CH2NHC(0)C(0)NH2, (0)R3,CH2OR3, NR3R4, N02, CH2NR3R4, C(Z)H, C(0)OR3, and C(0)NR3R4; 99 Z is selected from the group consisting of O, NR5, NOR3,s-NCN, C(-CN)2, CR3CN, CR3N02, CR3C(0)OR3, CR3C(0)NR3R3, C(-CN)N02i. C(-CN)C(0)OR5, and C(-CN)C(0)NR3R3 ' '; "■■',; R4 is selected from the group consisting of OR3 and R5; R3 is selected from the group consisting of hydrogen or substituted or unsubstituted alkyl, and halogen; R5 is selected from the group consisting of hydrogen, and substituted or unsubstituted alkyl; R6 is independently chosen from the group consisting of hydrogen, hydroxy, halogen, cyano, nitro, formyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heteroaryl ring, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted heterocyclylalkyl ring, substituted or unsubstituted amino, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted cyclic ring, substituted or unsubstituted alkylcarbonyl, 'substituted or unsubstituted alkylcarbonyloxy, substituted or unsubstituted carboxylic acid and S(0)mR6; m is 0,1 or 2; comprising (12) 100 (a) reacting a compound of the formula 12 wherein P1, R1, R2 and P are as defined above, with an alkali base and; acetylene in a polar aprotic solvent to produce a mixture of reaction products =and . ;•■,,, (b) isolating from step (a)a compound of formula IE. 21. The process according to claim 20 further comprising reacting said mixture of reaction products with Hg(II)OAc followed by reaction with a reagent chosen from the group consisting of Na BH4 and NaCNBUj. 22. The process according to claim 20 wherein said alkali base is KOH. 23. The process according to claim 20 wherein said polar aprotic solvent is DMSO. 24. The process according to claim 21 wherein said reagent is NaBK-t. 25. A process for the preparation of a compound of the general formula IB R6 (IB) wherein R1 is chosen independently selected for each occurrence from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstitued alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylakyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heterocyclic group, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted heteroarylalkyl , -C(0)-R', -C(0)0-R1, -C(0)NR1R1 and ■S(0)m-R'; 101 wherein P is selected from the group consisting of bond, oxygen, sulfur and NR ; wherein P1 is selected from the group consisting of hydrogen, halogen atom , -OR , -S(0)m R1, -C(0)R' , formyl amine, nitro and -NRxRy wherein RX and Ry are independently selected from the group consisting of hydrogen substituted or unsubstituted alkyl, haloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heterocyclylalkyl, and substituted or unsubstituted heteroarylalkyl; m is 0,1 or 2 R2 is selected from the group consisting of hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, CN, -CH=CR3R3, - c = c (R3)3 CH2NHC(0)C(0)NH2, (0)R3,CH2OR3, NR3R4, N02, CH2NR3R4, C(Z)H, C(0)OR3, and C(0)NR3R4 Z is selected from the group consisting of 0, NR5, NOR3, NCN, C(-CN)2, CR3CN, CR3N02, CR3C(0)OR3, CR3C(0)NR3R3, C(-CN)N02, C(-CN)C(0)0R5, and C(- CN)C(0)NR3R3 R4 is selected from the group consisting of OR3 and R5; R3 is selected from the group consisting of hydrogen or substituted or unsubstituted alkyl, and halogen; R3 is selected from the group consisting of hydrogen, and substituted or unsubstituted alkyl; R is chosen independently from the group consisting of hydrogen, hydroxy, halogen, cyano, nitro, formyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heteroaryl ring, substituted or unsubstituted heteroarylalkyl, 102 substituted or unsubstituted heterocyclylalkyl ring, substituted or unsubstituted amino, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted cyclic ring,, substituted or unsubstituted alkylcarbonyl, 'substituted, or unsubstituted alkylcarbonyloxy, substituted or unsubstituted carboxylic acid and S(0)mR ; m is 0,1 or 2; comprising reacting a compound of the formula 11 (11) wherein P1, R1, R2 and P have meanings as described above; with a compound of the formula H2N-NHR6 in an alcoholic solvent at a temperature of about 20 to about 60°C. 26. A process accoding to claim 25 wherein said alcoholic solvent is chosen from the group consisting of methanol and ethanol. 27. A process for the preparation of a compound of the general formula 103 unsubstituted heterocyclic group, substituted or unsubstituted/-heterocyclylalkyl, substituted or unsubstituted heteroarylalkyl , -C(0)-R\ -C(0)QrR1,'-C(0)NR1R1 and wherein P is selected from the group consisting of bond, oxygen, sulfur and NR ; wherein P1 is selected from the group consisting of hydrogen, halogen atom , -OR , -S(0)m R1, -C(0)R' , formyl amine, nitro and -NRxRy wherein RX and Ry are independently selected from the group consisting of hydrogen substituted or unsubstituted alkyl, haloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heteroarylalkyl; m is 0,1 or 2 R2 is selected from the group consisting of hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, CN, -CH=CR3R3, - c = c (R3)? CH2NHC(0)C(0)NH2, (0)R3,CH2OR3, NR3R4, N02, CH2NR3R4, C(Z)H, C(0)OR3, and C(0)NR3R4; Z is selected from the group consisting of 0, NR5, NOR3, NCN, C(-CN)2, CR3CN, CR3N02, CR3C(0)OR3, CR3C(0)NR3R3, C(-CN)N02, C(-CN)C(0)0R5, and C(- CN)C(0)NR3R3; R4 is selected from the group consisting of OR3 and R5; R is selected from the group consisting of hydrogen or substituted or unsubstituted alkyl, and halogen; R5 is selected from the group consisting of hydrogen, and substituted unsubstituted alkyl; R° and R' are independently chosen from the group consisting of hydrogen, hydroxy, halogen, cyano, nitro, formyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted 104 cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heteroaryl ring, substituted or unsubstituted heteroarylal-kyl, substituted or unsubstituted heterocyclylalkyl ring, substituted or unsubstituted amino, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted cyclic ring, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkylcarbonyloxy, substituted or unsubstituted carboxylic acid and S(0)mR6; where m is 0,1 or 2 and R ; comprising reacting a compound of the formula 11 wherein P1, R1, R2 and P have meanings as described above with a compound of formula (16) (16) in an alcoholic solvent in the presence of a base at a temperature of about 20 to about 70°C. 28. The process according to claim 27 wherein said alcoholic solvent is chosen from the group consisting of ethanol and methanol. 29. A process for the preparation of novel compounds of the general formula (I) as defined in claim 1 their analogs, their tautomers, their regioisomers, their 105 diasteromers, their stereoisomers, their geometrical isomers", their N-oxides, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutical^ acceptable solvates substantially as herein described with reference to the Examples. 30. A pharmaceutical composition comprising a compound according to claims 1-14 or 15 and pharmaceutically acceptable salts or solvates thereof as well as pharmaceutically acceptable diluents or carriers. 31. A method of treating inflammatory diseases, disorders and conditions characterized by or associated with an undesirable inflammatory immune response and all disease and conditions induced by or associated with an excessive secretion of TNF-a and PDE-4 which comprises administering to a subject a therapeutically effective amount of a compound according to claims 1-14 or 15. 32. A method of treating inflammatory conditions and immune disorders in a subject in need thereof which comprises administering to said subject a therapeutically effective amount of a compound according to claims 1-14 or 15. 33. The method according to claim 32 wherein said inflammatory conditions and immune disorders is chosen from the group consisting of asthma, bronchial asthma chronic obstructive pulmonary disease, allergic rhinitis, eosinophilic granuloma, nephritis, rheumatoid arthritis, cystic fibrosis, chronic bronchitis, multiple sclerosis, Crohns disease, psoraisis, uticaria, adult vernal cojunctivitis, respiratory distress syndrome, rhematoid spondylitis, osteoarthritis, gouty arthritis, uteltis, allergic conjunctivitis, inflammatory bowel conditions, ulcerative coalitis, eczema, atopic dermatitis and chronic inflammation. 34. The method according to claim 32 wherein said inflammatory condition is an allergic inflammatory condition. 35. The method according to claim 32 wherein said inflammatory conditions and immune disorders are selected from the group consisting of inflammatory conditions or immune disorders of the lungs, joints, eyes, bowels, skin and heart. 106 36. The method according to claim 33 whrein said inflammatory,condition is chosen from the group consisting of bronchial asthma, nepritis, and allergic, rhinitis. 37. A method for abating inflammation in an affected organ or tissue comprising delivering to said organ or tissue a therapeutically effective amount of a compound represented by a compound according to claims 14 or 15. 38. A method of treating diseases of the central nervous system in a subject in need thereof which comprises administering to said subject a therapeutically effective amount of a compound according to claims 1-14 or 15. 39. The method according to claim 37 wherein said diseases of the central nervous system are chosen from the group consisting of depression, amnesia, dementia, Alzheimers disease, cardiac failure, shock and cerebrovascular disease. 40. A method of treating insulin resistant diabetes in a subject in need thereof which comprises administering to said subject a therapeutically effective amount of a compound according to claims 1-14 or 15. N4K 2003 Dated this Effih'tee.n C\S) dayof ^v^wst Signed_ GLENN SALDANHA Managing Director Glenmark Pharmaceuticals Limited 107