DETAILED DESCRIPTION OF THE INVENTION

Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties

Hexylresorcenol is a white to off-white powder, freely soluble in ether and acetone; very slightly soluble in water.

Benzalkonium chloride is an organic salt called a quaternary ammonium compound.

Benzalkonium chloride solution is a topical antiseptic. It works by preventing infection. It is a clear, colourless or slightly yellowish liquid, miscible with water and with alcohol. It froths copiously when shaken.

The present invention relates to a taste masked Hexylresorcenol and Benzalkonium chloride formulation in the form of compressed lozenges (troche composition) which imparts a favorable oral sensation. An attempt was made to formulate and evaluate lozenges of Hexylresorcenol and Benzalkonium chloride using different sugars, flavours & colours for optimization.

The pharmaceutical compositions according to the present invention are in the form of compressed lozenges containing sugar (Saccharose, Fructose, or other crystallizable sugars) or without sugar, based on polyalcohols (Sorbitol, Xylitol, Mannitol, Isomalt, Maltitol and the like) in combination with artificial sweeteners(Aspartame, Sucralose, Saccharin, Neotame, Acesulfame K, Cyclamate).

According to the present invention, the process for preparation of said lozenges comprises the following steps:

a) Granulating Hexylresorcenol and Benzalkonium chloride and Mannitol/Glucose powder with binder.
b) Dry the wet mass till required LoD is achieved.
c) Mill the dried granules using suitable mesh.
d) Lubricate the dried sifted granules with remaining materials.
e) Compress the lubricated granules at high hardness using suitable punch set.
The prepared lozenges were evaluated for various parameters like thickness, Hardness, &

CLAIMS:
1. A Novel Solid oral lozenges pharmaceutical compositions comprises Hexylresorcinol and Benzalkonium Chloride.
2. A novel solid oral lozenges of claim 1, comprises of Sweetner, Binding agent, Colours and Flavours.
3. A novel solid oral lozenges of claim 2, wherein sugar is selected from Sugar
(Sucrose, Glucose, Dextrose, Fructose), Sugar Alcohols
(Sorbitol, Xylitol, Mannitol, Maltitol, Erythritol, Isomalt, Lactitol, Glycerol) or Artificial
Sweeteners (Aspartame, Sucralose, Saccharin, Neotame, Acesulfame K, Cyclamate).
4. A novel solid oral lozenges of claim 3, wherein binding agent is Ethyl cellulose/Polyvinyl pyrrolidone/ Methacrylic Acid Copolymers/ Hypromellose.
5. A novel solid oral lozenges of claim 4, wherein contain suitable Colours and Flavours.
6. A novel solid oral lozenges of claim 5, is in the form of compressed tablet.