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Novel Phenylamine Compounds

Abstract: The present invention relates to 4-substituted phenylamidine derivatives of the general formula (I) wherein R5-R6 ArA4 D G B Q and an integer m have the meanings as defined in the description. The invention further relates to methods for their preparation and use of said compounds for controlling undesired phytopathogenic microorganisms and agents for said purpose comprising said phenylamine derivatives. This invention further relates to a method for controlling undesired phytopathogenic microorganisms by application of said 4-substituted phenylamidine derivatives of general formula (I) to such undesired microorganisms and/or to their habitat according to the invention.

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Patent Information

Application #
Filing Date
17 October 2019
Publication Number
49/2019
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
PRABHAKAR@VUTTS.COM
Parent Application
Patent Number
Legal Status
Grant Date
2023-02-06
Renewal Date

Applicants

PI INDUSTRIES LTD.
5th Floor, Vipul Square, B Block, Sushant Lok, Phase -1, Gurgaon 122009

Inventors

1. NAIK, Maruti
Bunder Road 6th Cross, Hanuman Nagar, Bhatkal, Karnataka 581320
2. MAHAJAN, Vishal A.
A-102, Neco Skypark, Vishal Nagar, Pimple Nilakh, Pune Maharashtra 411027
3. WALUNJ, Gulab E.
A/P Khanderaywadi, Post: Pimpalgaon Depa, Tal. Sangamner Dist: Ahmednagar Maharashtra 422605
4. NIVDUNGE, Dipak D.
Nivdungewadi, Post: Takali Dhokeshwar; Tal.: Parner, Dist: Ahmednagar, Maharashtra 414304
5. MANJUNATHA, Sulur G
E-714, Golden Magic, Brigade Gardenia, JP Nagar, 7th Phase, Bangalore 560078
6. GARG, Ruchi
B 38/47 C-1-K, Tulsipur, Mahmoorganj, Varanasi Uttar Pradesh 221010
7. AUTKAR, Santosh Shridhar
Post, Vyala, Taluka, Balapur, Dist. Akola, Maharashtra 444302
8. TEMBHARE, Nitin Ramesh
Mendha, PO-Thanegaon, Tehsil-Tirora, District-Gondia Maharashtra 441911
9. VENKATESHA, Hagalavadi M
#8, 2nd Main Road, Byraveshwaranagar, Nagarbhavi Road, Bengaluru Karnataka 560072
10. POSCHARNY, Konstantin
Mendelssohnstr. 25, 40233 Duesseldorf
11. KLAUSENER, Alexander G.M.
Schiffgesweg 18, 50259 Pulheim

Specification

The present invention relates to compounds intended to protect crops by fighting undesired phytopatliogenic microorganisms. More precisely, the subject of the present invention relates to novel phenylamine compounds used to protect crops by fighting undesired phytopatliogenic microorganisms. BACKGROUND OF THE INVENTION The control of damages to crops caused by phytopatliogenic microorganisms is extremely important in achieving high crop efficiency. For instance, plant disease damage to ornamental, vegetable, field, cereal, and fruit crops can cause significant reduction in productivity and thereby result in increased costs to the consumer. Many products are commercially available to control such damages. The need continues for new compounds which are more effective, less costly, less toxic, and environmentally safer and/or have different modes of action. Certain phenylamine derivatives are disclosed in literature as microbiocidally active ingredients in pesticides. For example, WO2000046184, WO2003093224 WO2005120234 WO2007031507 WO2007031526 WO200703 1 524 WO2007031523 WO2007031513 WO2007031 508 WO2007031512 WO2007061 966 WO2007093227 WO2008064780 WO20081 10314 WO20081 103 13 WO20081 10315 WO20081 10278 WO20081 10279 WO20081 10280 WO20081 10281 WO20081 1031 2 WO2008128639 WO2009053250 WO2009083105 WO2009088103 WO2009156098 WO2009156074 WO20100861 18 WO20101 1 5758 WO201 1082941 WO201 1 120912 WO2012019998 WO2012025450 WO2012060401 WO2012090969 WO2013018735 WO2013 136275 WO20140373 15 WO20140373 14 WO20141 1 9617 WO2014157596 WO2015025962 WO2015121231 WO201 5121 802 WO2016202742 WO2016202688 WO2017005710 WO2017063973 WO2017067839 WO201 7067837 WO201 7102635 and CN 107200712 discloses the phenylamidine derivatives and their use, either alone or as part of composition, as fungicides. ; The effectiveness of the phenylamidine derivatives described in the prior art is good, but leaves something to be desired in various cases. Therefore, it is always of high interest in agriculture to use novel pesticidal compounds in order to avoid and/or control the development of microorganisms such as fungal or bacterial pathogens or pests being resistant to known active ingredients. It is therefore of high interest to use novel compounds being more active than those already known, with the aim of decreasing the amounts of active compound to be used, whi lst at the same time maintaining an effectiveness at least equivalent to the already known compounds. We have now found a new family of compounds which possess the above mentioned effects or advantages. A new fami ly of compounds namely, novel phenylamidine derivatives wherein the phenyl ring is substituted according to the invention thus allowing an unexpected and significantly higher activity against undesired microorganisms such as fungal or bacterial pathogens or pests. SUMMARY OF THE INVENTION This present invention relates to 4-substituted phenylamine derivatives of the general formula (I) wherein the substituents of (I) are as defined in the description and claims. The present invention also relates to agriculturally acceptable salts, structural isomers, stereo-isomers, diastereomers, enantiomers, tautomers, metal complexes, polymorphs, compositions or N-oxides of the compound of formula (I). The present invention also relates to a composition comprising at least one compound of the present invention and optionally at least one other active compound selected from fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, plant growth regulators, antibiotics, fertilizers and or mixtures thereof. The present invention further relates to the use of the compound, the combination or the composition of the present invention and method of using the same, particularly in the field of agriculture mainly for protecting plants. The compounds of the present invention are novel and have enhanced activity against microbials, particularly phytopathogenic fungi. The compounds of the present invention have application in the field of agriculture or may be used as intermediates for synthesizing compounds having wider appl ications. DETAILED DESCRIPTION OF THE INVENTION The present invention relates to compounds of general formula (I) wherein R ' is selected from the group consisting of hydrogen, CN, SR", OR", C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkynyl, C2-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, cyclic C3-C8-alkyl, cyclic C4-C8-alkeny!, cyclic C4_C8-a!kynyl; wherein one or more carbon atoms in cycl ic ring system may be replaced by heteroatoms selected from the group consisting of N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2; R2 and R3 are independently selected from the group consisting of hydrogen, CN, S(0)nR", OR", (C=0)-R", C2-C12-alkyl, C2-C12-alkenyl, C2-C12-alkynyl, C1-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, cyclic C3.Cg-alkyl, cyclic C4-C8-alkenyl, cyclic C4-C8-alkynyl, C5-C18-aryl, C7-C 19-aralkyl, ; wherein one or more carbon atoms in cyclic ring system may be replaced by heteroatoms selected from the group consisting of N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2; or R 1 and R2, R2 or R3 or R ' and R3 together with the atoms to which they are attached or together with further atoms selected from the group consisting of C, N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2 may form a three to seven membered ring, which for its part may be substituted by one or more X, R', OR', SR', NR'2, SiR'3, COOR', CN or CONR'2; wherein, each of R1, R2 ;and R3 may optionally be substituted by one or more groups selected from the group consisting of X, R', OR', SR', NR'2, SiR'3, COOR', CN or CONR'2; A i_ A2. A3 and A4 represent CR4 or nitrogen; with the proviso that no more than two of A K A2 A3 and A4 are to be nitrogen simultaneously. R4 is independently selected from the group consisting of hydrogen, X, CN, NR"2. SCN, SF5, S(0)nR", SiR'j, OR", (C=0)-R", CR'=NR", C1-C12-alkyl, C2-C12-alkenyI, C2-C12-alkynyl, C1-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, cyclic C3-C8-alkyl, cyclic C4-C8-alkenyl, cyclic C4-C8-alkynyl, C5.C 18- aryl, C7-C19-aralkyl; wherein one or more carbon atoms in cyclic ring system may be replaced by heteroatoms selected from the group consisting of N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2; or two R4 together with the atom to which they are attached or together with further atoms selected from the group consisting of C, N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2 may form a four to seven membered ring, which for its part may be substituted by one or more X, R', OR', SR', NR'2, SiR'j, COOR', CN or CONR'2; G and B represent O, S, NR'" or CR5R6; m represents an integer of 1 or 2; R5 and R6 are independently selected from the group consisting of hydrogen, X, CN, NR"2 SCN, S(0)„R", SiR'j, OR', (C=0)-R", CR'=NR", C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkynyl, C1-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, cyclic C3-C8-alkyl, cyclic C4-C8-alkenyl, cyclic C4-C8-alkynyl, C5-C18-aryl, C7_C19-aralkyl; wherein one or more carbon atoms in cyclic ring system may be replaced by heteroatoms selected from the group consisting of N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2; or R5 and R6 together with the atom to which they are attached or together with further atoms selected from the group consisting of C, N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2 may form a three to seven membered ring, which for its part may be substituted by one or more X, R', OR', SR', NR'2, SiR'3s COOR', CN or CONR'2; or R5 and R6 together represent group selected from =S, =0; Q is selected from the group consisting of fused or non-fused C3.C]5- carbocyclyl or C3.C15- heterocyclyl; which may be optionally substituted by one or more groups of R7; wherein R7 is selected from the group consisting of hydrogen, X, CN, SCN, SF5, OR", N02, NR"2, SiR'3, (C=0)-R", S(0)„R", C ,.Cg-alkyl-S(0)„R", C ,.C8-alkyl-(C=0)-R", CR'=NR", S(0)n C5-C18-aryl, S(0)n C7-C19-aralkyl, C1-C12-a!kyl, C2-C12-alkenyl, C2-C12-alkynyl, C2-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, C1-C12-alkoxy, C1-C12-alkylthio, C1-C12-haloalkoxy, C1-C12-haloalkylthio, cyclic C3-C8-alkyl, cyclic C3-C8-haloal kyl, cycl ic C4-C8-alkenyl, cyclic C4-C8-aIkynyl, bicyclic C5.12-alkyl, C7.C |2-alkenyl, C6. C |5-aryl, C7_C19-aralkyl, C3-C6-heterocyclyl, C3-C8-heterocyclylalkyl, C3-C6-heterocyclyloxy, C3-C6-heterocyclylthio; wherein one or more carbon atoms in cyclic ring system may be replaced by heteroatoms selected from the group consisting of N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2; or two R7 together with the atom to which they are attached or together with further atoms selected from the group consisting of C, N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2 may form a three to seven membered ring, which for its part may be substituted by one or more X, R', OR', SR', NR'2, SiR'3, COOR', CN or CONR'2; wherein, each one of R4, R3, R6, and R7 may optionally be substituted by one or more groups selected from the group consisting of X, R', R", SR', SiR'3, COOR', CN or CONR'2; wherein X represents halogen; R' represents hydrogen, C,.C|2-alkyl or cyclic C3.Ci0-alkyl which may be optionally substituted by one or more X; R" represents hydrogen, NR'2, CONR'2, OR', C].C,2-alkyl, C1-C12-haloalkyl, cyclic C3-C8-alkyl which may be optionally substituted by one or more groups selected from the group consisting of X, R', OR', SR', NR'2, SiR'3s COOR', CN or CONR'2, C5-C18-aryl which may be optionally substituted by one or more X, R', OR', SR', NR'2, SiR'3, COOR', CN or CONR'2; wherein one or more carbon atoms in cyclic ring system may be replaced by heteroatoms selected from the group consisting of N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2; R'" is selected from the groups consisting of hydrogen, R", CN, OR', (C=0)-R', COOR', CONR'2, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkynyl, cyclic C3-C8-alkyl, cyclic C4-C8-alkenyl, cyclic C4. C8-alkynyl, C5-C18-aryl, C7-C19-aralkyl ; wherein one or more carbon atoms in cyclic ring system may be replaced by heteroatoms selected from the group consisting of N, 0, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2; each of the above groups may be substituted by one or more groups selected from the group consisting of X, R', OR', SR', NR'2, SiR'3, COOR', CN or CONR'2; n represents an integer ranging from 0 to 2; According to an embodiment, R1 is selected from hydrogen, C^Qralkyl, C1-C6-alkoxy, C1-C6.alkylthio, C jXVhaloalkyl or C3-C8-cycloalkyl. According to a more preferred embodiment, R1 is selected from hydrogen, C1-C6-alkyl or C3.C5-cycloalkyl. According to an embodiment, R2 and R3 are independently selected from CN, C1-C6-aIkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-haloalkyI, C3-C8-cycloalkyl or non aromatic C3-C8-heterocyclyl. According to one another embodiment R1 and R2or R3 or R1 and R3 together with the atoms to which they are attached or together with further atoms selected from the group consisting of C, N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)1T1 and SiR'2 may form a three to seven membered non aromatic ring, which for its part may be substituted by one or more X, R', OR', SR', (C=0)-R", or CN. According to one another embodiment the substitutions R1 and R2, R2 and R3 or R1 and R3 together with the atoms to which they are attached form a optionally substituted cyclic ring system selectd from azetidine, pyrrolidine, imidazolidine, oxazolidine, piperidine, morpholine, thiomorpholine, piperazine, 1 -methylpiperazine, l -methylpyrrolidine, 1 -methylpiperidine, 3-methyl- l ,3-thiazinane. According to an embodiment, R4 is independently selected from hydrogen, X, CN, S(0)nR", NR'R", (C=0)-R", CR'=NR", C1-C6-alkyl, C2-C6-alkenyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkylthio, C3_ C8-cycloalkyl or C3-C8-cycloalkylthio. According to an embodiment, R5 and R6 are independently selected from hydrogen, X, CN, S(0)nR", NR'R", (C=0)-R", CR'=NR", C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C3-C8-cycloalkyl, C3_C8-cycloalkoxy, C3-C8-cycloalkylthio. According to an embodiment R5 and R6 together with the atom to which they are attached or together with further atoms selected from the group consisting of C, N, O, S may form a three to six membered ring, which for its part may be substituted by one or more X, R', OR', SR', NR'2, SiR'3, COOR', CN, or CONR'2. According to an embodiment, R7 is selected from hydrogen, X, CN, SCN, SF5, R", OR", N02, NR"2, SiR'3, (C=0)-R", S(0)„R", C,.C8-alkyl-S(0)nR", C1-C6-alkyl-(C=0)-R", CR'=NR", C2_C6-alkenyl, C2-C6-alkynyl, C1-C6 haloalkyl, C2-C6-haloalkenyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-haloalkoxy, C1-C6-haloalkylthio, C3-C8-cycloaIkyl, C4-C8-cycloalkenyl, C3-C8-cycloalkyloxy or C3-C8-cycloalkylthio. In one another embodiment two R7 together with the atom to which they are attached or together with further atoms selected from the group consisting of C, N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0),„ and SiR'2 may form a four to ten membered ring, which for its part may be substituted by one or more X, R', OR', SR', NR'2, SiR'3, COOR', CN or CONR'2 In one another embodiment Q is selected from cyclopropyl, cyclobutyl, phenyl , napthalenyl, furyl, thienyl, pyrrolyl, isoxazolyl, isothiazolyl, pyrazolyl, oxazolyl, imidazolyl, oxadiazolyl, triazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, indolyl, benzimidazolyl, indazolyl, benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl, quinolinyl, isoquinolinyl, quinazolinyl, cinnonyl, indolizinyl, pyrazo!o[ l ,5-a]pyridinyI, imidazo[ l ,2-a]pyridinyl, pyrrolo[ l ,2-a]pyrimidinyl, pyrazolo[ l ,5-ajpyrimidinyl, imidazo[ l ,2-a]pyrimidinyl, pyrrolo[ l ,2-a]pyrazinyl, pyrazolo[l ,5-a]pyrazinyl, imidazo[ l ,2-a]pyrazinyl ; substituted with one or more R7. According to preferred embodiment Q is selected from cyclopropyl, phenyl, napthalenyl, thienyl, isothiazolyl, thiazolyl, thiadiazolyl, pyrazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl; substituted with one or more R7. Another embodiment provides, the use of compound of formula (I) and compositions thereof, for controlling or preventing against phytopathogenic fungi of agricultural crops and or horticultural crops. A preferred embodiment provides, the use of compounds of formula (I) and compositions thereof, foicontrolling plant diseases: Puccinia spp. (rusts) on various plants, selected from, but not limited to P. triticina (brown or leaf rust), P. striiformis (stripe or yellow rust), P. hordei (dwarf rust), P. graminis (stem or black rust) or P. recondita (brown or leaf rust) on cereals, selected from wheat, barley or rye and Phakopsoraceae spp. on various plants, in particular Phakopsora pachyrhiziand P. meibomiae (soybean rust) on soybeans. A preferred embodiment provides for, the use of compound of formula (I) and compositions thereof, more precisely for controlling and/or preventing against phytopathogenic fungi such as Phakopsora pachyrhizi, Phakopsora meibomiae, of agricultural crops and or horticultural crops. A further preferred embodiment provides for the use of compound of formula (I) and compositions thereof, that are particularly suitable for controlling and/or preventing against diseases of the agricultural crops such as cereals, corn, soybean and other leguminous plants; fruits and fruit trees; nuts and nut trees; citrus and citrus trees; any horticultural plants; oleaginous plants; coffee, tea, and other vegetables, and ornamentals. DEFINITIONS: The following definitions provided for the terminologies used in the present disclosure are for illustrative purpose only and in no manner limit the scope of the present invention disclosed in the present disclosure. The transitional phrase "comprises", "comprising", "includes", "including", "has", "having", "contains", "containing", "characterized by" or any other variation thereof, are intended to cover a non-exclusive inclusion, subject to any limitation explicitly indicated. For example, a composition, mixture, process or method that comprises a list of elements is not necessarily l imited to only those elements but may include other elements not expressly listed or inherent to such composition, mixture, process or method. The transitional phrase "consisting of excludes any element, step or ingredient not specified. If in the claim, such would close the claim to the inclusion of materials other than those recited, except for impurities ordinarily associated therewith. When the phrase "consisting of appears in a clause of the body of a claim, rather than immediately following the preamble, it l imits only the element set forth in that clause; other elements are not excluded from the claim as a whole. The transitional phrase "consisting essentially of is used to define a composition or method that includes materials, steps, features, components or elements, in addition to those l iterally disclosed, provided that these additional materials, steps, features, components or elements do not materially affect the basic and novel characteristic(s) of the claimed invention. The term "consisting essentially of occupies a middle ground between "comprising" and "consisting of. Further, unless expressly stated to the contrary, "or" refers to an inclusive "or" and not to an exclusive "or". For example, a condition "A" or "B" is satisfied by any one of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and both A and B are true (or present). Also, the indefinite articles "a" and "an" preceding an element or component of the present invention are intended to be nonrestrictive regarding the number of instances (i.e. occurrences) of the element or component. Therefore "a" or "an" should be read to include one or at least one, and the singular word form of the element or component also includes the plural unless the number is obviously meant to be singular. As referred to in this disclosure, the term "pesticide" in each case also always comprises the term "crop protection agent". The term "undesired microorganisms" or "phytopathogenic microorganisms" such as fungal or bacterial pathogens includes namely Plasmodiophoromycetes, Oomycetes, Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes and Pseudomonadaceae, Rhizobiaceae, Enterobacteriaceae, Corynebacteriaceae and Slreptomycelaceae respectively. The term "agronomic" refers to the production of field crops such as for food, fuels, biofuels, any biomaterials and fiber and includes namely the growth of corn, soybeans and other legumes, rice, cereal (e.g., wheat, oats, barley, rye, rice, maize), leafy vegetables (e.g., lettuce, cabbage, and other cole crops), fruiting vegetables (e.g., tomatoes, pepper, eggplant, crucifers and cucurbits), potatoes, sweet potatoes, grapes, cotton, tree fruits (e.g., pome, stone and citrus), small fruit (berries, cherries), biofuel production crops such as corn, sugar/starch crops, sugar-beet and sweet sorghum, cellulosic crops such as switchgrass, miscanthus, corn stover, poplar, biodiesel crops rapeseed (canola), soybeans, palm oil, mustard, camelina, safflower, sunflower and jatropha and other specialty crops (e.g., canola, sunflower, olives). The term "nonagronomic" refers to other than field crops, such as horticultural crops (e.g., greenhouse, nursery or ornamental plants not grown in a field), residential, agricultural, commercial and industrial structures, turf (e.g., sod farm, pasture, golf course, lawn, sports field, etc.), wood products, stored product, agro-forestry and vegetation management, public health (i.e. human) and animal health (e.g., domesticated animals such as pets, livestock and poultry, undomesticated animals such as wildlife) applications. Alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl and heteroaryl groups, as defined herein, are optionally substituted (e.g., "substituted" or "unsubstituted" alkyl, "substituted" or "unsubstituted" alkenyl, "substituted" or "unsubstituted" alkynyl, "substituted" or "unsubstituted" carbocyclyl, "substituted" or "unsubstituted" heterocyclyl, "substituted" or "unsubstituted" aryl or "substituted" or "unsubstituted" heteroaryl group). In general, the term "substituted", whether preceded by the term "optionally" or not, means that at least one hydrogen present on a group (e.g., a carbon or nitrogen atom etc.) is replaced with a permissible substituent, e.g., a substituent which upon substitution results in a stable compound, e.g., a compound which does not spontaneously undergo transformation such as by rearrangement, cyclization, elimination, or other reaction under normal conditions (temperature, pressure, air etc.). Unless otherwise indicated, a "substituted" group has a substituent at one or more substitutable positions of the group, and when more than one position in any given structure is substituted, the substituent is either the same or different at each position. Any of the compounds according to the invention can exist in one or more optical, geometric or chiral isomer forms depending on the number of asymmetric centres in the compound. The invention thus relates equally to all the optical isomers and to their racemic or scalemic mixtures (the term "scalemic" denotes a mixture of enantiomers in different proportions), and to the mixtures of all the possible stereoisomers, in all proportions. The diastereomers and/or the optical isomers can be separated according to the methods which are known per se by a person ordinary skilled in the art. Any of the compounds according to the invention can also exist in one or more geometric isomer forms depending on the number of double bonds in the compound. The invention thus relates equally to all geometric isomers and to all possible mixtures, in all proportions. The geometric isomers can be separated according to general methods, which are known per se by a person ordinary ski lled in the art. Any of the compounds according to the invention, can also exist in one or more amorphic or isomorphic or polymorphic forms, depending on their preparation, purification storage and various other influencing factors. The invention thus relates all the possible amorphic, isomorphic and polymorphic forms, in all proportions. The amorphic, isomorphic and polymorphic forms can be prepared and/or separated and/or purified according to general methods, which are known per se by a person ordinary skil led in the art. The term "alkyl ", used either alone or in compound words such as "alkylthio" or "haloalkyl " or -N(alkyl) or alkylcarbonylalkyl or alkylsuphonylamino includes straight-chain or branched C i to C2 OR", (C=0)-R", CR'=NR", C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkynyl, C1-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, cyclic C3-C8-alkyl, cyclic C4.Cg-alkenyl, cyclic C4-C8-alkynyl, C5. C |R-aryl, C7_C l 9-aralkyl; wherein one or more carbon atoms in cyclic ring system may be replaced by heteroatoms selected from the group consisting of N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2; or two vicinal R4 together with the atom to which they are attached or together with further atoms selected from the group consisting of C, N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and Si R'2 may form a four to seven membered ring, which for its part may be substituted by one or more X, R', OR', SR', NR'2, SiR'3, COOR', CN or CONR'2; G and B represent O, S, NR'" or CR5R6; m represents an integer of 1 or 2; R5 and R6 are independently selected from the group consisting of hydrogen, X, CN, NR"2 SCN, S(0)nR", SiR'3, OR', (C=0)-R", CR'=NR", C1-C12-alkyl, C2_C12-alkenyl, C2-C12-alkynyl, C1-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, cyclic C3.Cg-alkyl, cyclic C4-C8-alkenyl, C5.C |8-aryl, C7_C19-aralkyl; wherein one or more carbon atoms in cyclic ring system may be replaced by heteroatoms selected from the group consisting of N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)„, and SiR'2; or R5 and R6 together with the atom to which they are attached or together with further atoms selected from the group consisting of C, N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2 may form a three to seven membered ring, which for its part may be substituted by one or more X, R', OR', SR', NR'2j SiR'3, COOR', CN or CONR'2; or R5 and R6 together represent group selected from =0, =S; Q is selected from the group consisting of fused or non-fused C3.C15-carbocycle or C3.C |5-heterocycle; which may be optionally substituted by one or more groups of R7; wherein R7 is selected from the group consisting of hydrogen, X, CN, SCN, SF5, OR", N02, NR"2, SiR'3, (C=0)-R", S(0)nR", C ,.C8-alkyl-S(0)nR", C,.C8-alkyl-(C=0)-R", CR'=NR", S(0)nC5.C18-aryl, S(0)nC7-C ,9-aralkyl, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkynyl, C].C ]2-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, C1-C12-alkoxy, C1-C12-alkylthio, C1-C12-haloalkoxy, C1-C12-haloalkylthio, cyclic C3-C8-alkyl, cyclic C3_C8-haloalkyl, cyclic C4-C8-alkenyI, cyclic C4-C8-alkynyl, bicyclic C5.|2-alkyl, bicycl ic C7.C 12-alkenyl, C6.C |5-aryl, C7_C19-aralkyl, C3-C6-heterocyclyl, C3-C8-heterocyclylalkyl, C3-C6-heterocyclyloxy, C3-C6-heterocyclylthio; wherein one or more carbon atoms in cyclic ring system may be replaced by heteroatoms selected from the group consisting of N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0),„ and SiR'2; or two R7 together with the atom to which they are attached or together with further atoms selected from the group consisting of C, N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2 may form a three to seven membered ring, which for its part may be substituted by one or more X, R', OR', SR', NR'2, SiR'3) COOR', CN or CONR'2; wherein, each one of R4, R5, R6 and R7 may optionally be substituted by one or more groups selected from the group consisting of X, R', R", SR', SiR'3, COOR', CN or CONR'2; wherein X represents halogen; R' represents hydrogen, C1-C6-alkyl or cyclic C3-C8-alkyl which may be optionally substituted by one or more X; R" represents hydrogen, CONR'2, NR'2, OR', C1-C6-alkyl, C1-C6-haloalkyl or cyclic C3-C8-alkyl which may be optional ly substituted by one or more groups selected from the group consisting of X, R', OR', SR', NR'2, SiR'3> COOR', CN or CONR'2; or C6.C 12-aryl which may be optionally substituted by one or more X, R', OR', SR', NR'2, SiR'3, COOR', CN or CONR'2; wherein one or more carbon atoms in cyclic ring system may be replaced by heteroatoms selected from the group consisting of N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2; R'" is selected from the groups consisting of hydrogen, R", OR", (C=0)-R', S(0)nR", COOR', CONR'2, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, cyclic C3-C8-alkyl, Cc.C i2-aryI, C7.C |2-aralkyl; wherein one or more carbon atoms in cyclic ring system may be replaced by heteroatoms selected from the group consisting of N, O, S, and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2; and each of the above groups may be substituted by one or more groups selected from the group consisting of X, R', OR', SR', NR'2, SiR'j, COOR', CN or CONR'2; n represents an integer ranging from 0 to 2; and agronomically acceptable salts, metallic complexes, isomers/structural isomers, stereo-isomers, diastereomers, enantiomers, tautomers, polymorphs, or N-oxides of said compounds. 2. A compound of general formula (1) according to claim 1 wherein: R1 is selected from hydrogen, C1-C6-alkyl, C : -C6-alkoxy, C1-C6.alkylthio, C1-C6-haloalkyl, or C3-C8-cycloalkyl; R2 and R3 are independently selected from CN, C1-C6-alkyl, C2-C6-alkenyl, C2-C6- alkynyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-haloalkyl, C3-C8-cycloalkyl or non aromatic C3_C8-heterocyclyl; or R1 and R2, R2 and R3 or R1 and R3 together with the atoms to which they are attached or together with further atoms selected from the group consisting of C, N, O, S and optionally including 1 to 3 ring members selected from the group consisti ng of C(=0), C(=S), S(0)m and SiR'2 may form a four to seven membered non-aromatic ring, which for its part may be substituted by one or more X, R', OR', SR' and CN; R4 is seleccted from hydrogen, X, CN, S(0)„R", N(R'R"), (C=0)-R", CR -NR", C1-C6-alkyl, C2-C6-alkenyl C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkylthio C1-C6-haloalkylthio, C3-C8-cycloalkyl, C3_C8-cycloalkylthio, C3-C8-heterocyclyl; or two vicinal R4 together with the atom to which they are attached or together with further atoms selected from the group consisting of C, N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2 may form a three to seven membered ring, which for its part may be substituted by one or more X, R', OR', SR', NR'2, SiR'3, COOR', CN or CONR'2; G and B represent O, S or NR"; R5 and R6 are independently selected from hydrogen, X, CN, S(0)nR", NR'R", (C=0)-R", CR'=NR", C,. C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C1-C6-alkoxy, C1-C6haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C3-C8-cycloalkyl, C3-C8-cycloalkoxy, C3-C8-cycloalkylthio or R5 and R6 together with the atom to which they are attached or together with further atoms selected from the group consisting of C, N, O, S may form a three to six membered ring, which for its part may be substituted by one or more X, R', OR', SR', NR'2, SiR'3, COOR', CN or CONR'2; R7 is selected hydrogen, X, CN, SCN, SF5, R", OR", N02, NR"2, SiR'3, OS(0)„R", OSiR'3, NR'S(0)nR", (C=0)-R", S(0)nR", C1-8-alkyl-S(0)„R", C1-C6-alkyl-(C=0)-R", CR'=NR", C1-C12-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C2-C6-haloalkenyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-haloalkoxy, C ,. C6-haloalkylthio, C3-C8-cycloalkyl, C4-8-cycloaIkenyl, C3-C8-cycloalkyloxy, C3-C8-cycloalkylthio; or two R7 together with the atom to which they are attached or together with further atoms selected from the group consisting of C, N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2 may form a four to ten membered ring, which for its part may be substituted by one or more X, R', OR', SR', NR'2, SiR'3, COOR', CN or CONR'2; Q is cyclopropyl, cyclobutyi, phenyl, napthalenyl, furyl, thienyl, pyrrolyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrazolyl, oxazolyl, imidazolyl, oxadiazolyl, triazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, indolyl, benzimidazolyl, indazolyl, benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl, quinolinyl, isoquinolinyl, iquinazolinyl, cinnonyl, indolizinyl, pyrazolo[ l ,5-a]pyridinyl, imidazo[l ,2-a]pyridinyl, pyrrolo[ l ,2-a]pyrimidinyl, pyrazolo[ l ,5-a]pyrimidinyl, imidazo[ l ,2-a]pyrimidinyl, pyrrolo[ l ,2-a]pyrazinyl, pyrazolo[l ,5-a]pyrazinyl, imidazo[l ,2-a]pyrazinyl substituted with one or more R7; wherein R1, R2, R3 R4, R5, R6 and R7 may further optionally substituted by one or more groups selected from the group consisting of X, R", OR', SR', NR'2, SiR'3, COOR', CN or CONR'2; and agronomically acceptable salts, isomers/structural isomers, stereo-isomers, diastereoisomers, enantiomers, tautomers, or N-oxides of said compounds 3. A compound of general formula (I) according to claim 1 or 2 wherein: R1 is selected from hydrogen or C1-C6-alkyl, C3-C8-cycloalkyl; R2 and R3 are independently selected from C1-C6-alkyl, C1_C6-haloalkyl or C3-C8-cycloalkyl; R4 is selected from hydrogen X, CN, S(0)nR', OR", N(R'R"), C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl; R5 and R6 are hydrogen, X, C1-C6-alkyI, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C3-C8-cycloalkyl or R5 and R6 together with the atom to which they are attached or together with further atoms selected from the group consisting of C, N, O, S may form a three to four membered ring, which for its part may be substituted by one or more X, R', OR', SR', NR'2, SiR'3, COOR', CN or CONR'2; R7 is selected from hydrogen, X, CN, SCN, SF5, R", OR", N02, NR"2, SiR'3, (C=0)-R", S(0)„R", OS(0)„R", NR'S(0)nR", OSiR'3, C ,.8-alkyl-S(0)nR", C1-C6-alkyl-(C=0)-R", CR'=NR", SC1-C6-alkyl, C2_ C6-alkenyl, C2-C6-alkynyl, C1-C6-ha!oalkyl, C2-C6-haloalkenyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-holoalkoxy, C1-C6-haloalkylthio, C3-C8-cycloalkyl, C4-8-cycloalkenyl, C3-C8-cycloalkyloxy, C3_C8-cycloalkylthio or two Rl(l together with the atom to which they are attached or together with further atoms selected from the group consisting of C, N, O, S and optionally including 1 to 3 ring members selected from the group consisting of C(=0), C(=S), S(0)m and SiR'2 may form a four to ten membered ring, which for its part may be substituted by one or more X, R', OR', SR', NR'2, SiR'3, COOR', CN, and CONR'2; Q is cyclopropyl, phenyl, napthalenyl, thieny, thiazole, thiadiazole, isothiazolyl, pyrazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and quinolinyl substituted with one or more R7; wherein R1 to R7 may further optionally substituted by one or more groups selected from the group consisting of X, R", OR', SR', NR'2, SiR'3, COOR', CN or CONR',; and agronomically acceptable salts, metallic complexes, isomers/structural isomers, stereo-isomers, diastereomers, enantiomers, tautomers, polymorphs, or N-oxides of said compounds. 4. A compound according to any one of claims 1 , 2 or 3 wherein compound of general formula (I) are: N'-(2,5-dimethyl-4-(2-(phenylthio)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-phenoxyacetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(3-bromophenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N-efhyl-N'-(4-(2-((3-fluorophenyl)thio)acetyl)-2,5-dimethylphenyl)-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-(m-tolylthio)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-((3-bromophenyl)thio)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N-ethyl-N'-(4-(2-((4-methoxyphenyl)thio)acetyl)-2,5-dimethylphenyl)-N-methylformimidamide; N'-(4-(2-((3,4-dichlorophenyl)thio)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N-ethyl-N'-(4-(2-(3-fiuorophenoxy)acetyl)-2,5-dimethylphenyl)-N-methylformimidamide; N-ethyl-N'-(4-(2-(4-methoxyphenoxy)acetyl)-2,5-dimethyIphenyl)-N-methylformimidamide; N'-(4-(2-((3,4-dimethylphenyl)thio)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-(m-tolyloxy)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(3-chlorophenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-(4-(trifluoromethoxy)phenoxy)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-(p-tolyloxy)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(4-chlorophenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-(3-(methylthio)phenoxy)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-5-methyl-4-(2-phenoxyacetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-(2-(3-chlorophenoxy)acetyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-(2-(4-chlorophenoxy)acetyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-((4-bromophenyl)thio)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(3-bromophenoxy)acetyl)-2-chloro-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-(2-(3-fluorophenoxy)acetyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-5-methyl-4-(2-(p-tolyloxy)acetyl)phenyl)-N-ethyl-N- methylformimidamide; N'-(2-chloro-5-methyl-4-(2-(m-tolyloxy)acetyl)phenyl)-N-ethyl-N-methylformimidamide: N-ethyl-N'-(4-(2-((3-methoxyphenyl)thio)acetyl)-2,5-dimethylphenyl)-N-methylformimidamide: N-ethyl-N'-(4-(2-((4-fluorophenyl)thio)acetyl)-2,5-dimethylphenyl)-N-methylformimidamide: N'-(4-(2-((4-chlorophenyI)thio)acetyI)-2,5-dimethyIphenyl)-N-ethyl-N-methylformimidamide: N'-(4-(2-((2-bromophenyl)thio)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide: N'-(4-(2-(2-bromophenoxy)acetyl)-2-chloro-5-methylphenyl)-N-ethyl-N-methylformimidamide: N-ethyl-N'-(4-(2-(2-fluorophenoxy)acetyl)-2,5-dimethylphenyl)-N-methyl for m i m i d am i de; N-ethyl-N'-(4-(2-(4-fluorophenoxy)acetyl)-2,5-dimethylphenyl)-N-methylformimidamide: N'-(4-(2-(2-bromophenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide: N'-(2-chloro-5-methyl-4-(2-(m-tolylthio)acetyl)phenyl)-N-ethyl-N-methylformimidamide: N'-(4-(2-((3-bromophenyl)thio)acetyl)-2-chloro-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-(2-((3-fluorophenyl)thio)acetyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-(2-((4-chlorophenyl)thio)acetyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-((2-bromophenyl)thio)acetyl)-2-chloro-5-methylphenyl)-N-ethyl-N-methyl form i m i dam i de: 2-(3-chlorophenoxy)- ] -(2,5-dimethyl-4-((morpholinomethylene)amino)phenyl)ethan- l-one; 2-(3-chlorophenoxy)- l -(2,5-dimethyl-4-((piperidin-l -ylmethylene)amino)phenyl)ethan-l -one; N'-(4-(2-(3-chlorophenoxy)acetyl)-2,5-dimethylphenyl)-N-isopropyl-N-methylformimidamide; N-allyl-N'-(4-(2-(3-chlorophenoxy)acetyl)-2,5-dimethylphenyl)-N-methylformimidamide; N'-(2-chloro-4-(2-(2-fluoiOphenoxy)acetyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-(2-(4-fluorophenoxy)acetyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(3-chlorophenoxy)acetyl)-2,5-dimethylphenyl)-N-cyanoformimidamide; N'-(4-(2-((3,4-dimethylphenyl)thio)acetyl)-2,5-dimethylphenyl)-N-isopropyl-N-methylformimidamide; N-allyl-N'-(4-(2-((3,4-dimethylphenyl)thio)acetyl)-2,5-dimethylphenyl)-N-methylformimidamide; l -(2,5-dimethyl-4-((morpholinomethylene)amino)phenyl)-2-((3,4-dimethylphenyl)thio)ethan-l -oneN'-(2-chloro-4-(2-((3,4-dichlorophenyl)thio)acetyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro- 4- (2-((3,5-dichlorophenyl)thio)acetyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro- 5- methyl-4-(2-(3-(methylthio)phenoxy)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-5-methyl-4-(2-(4-(trifluoromethoxy)phenoxy)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-(2-((4-fluorophenyl)thio)acetyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-((4-bromophenyl)thio)acetyl)-2-chloro-5-niethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-(2-((3-methoxyphenyl)thio)acetyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; ]\l'-(2-chloro-5-methyl-4-(2-(phenylthio)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(2-chIoro-4-(2-((2-fluorophenyl)thio)acetyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N-ethyl-N'-(4-(2-((2-iluorophenyl)thio)acetyl)-2,5-dimethylphenyl)-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-((3- (trifluoromethyI)phenyl)thio)acetyl)phenyl)-N-ethyl-N-methylformimidamide; 2-(3-chlorophenoxy)- l -(2,5-dimethyl-4-((thiomorpholinomethylene)amino)phenyl)ethan-l -one; l -(2,5-dimethyl-4-((thiomorpholinomethylene)amino)phenyl)-2-((3,4-dimethylphenyl)thio)ethan- l -one; N'-(4-(2-((3-chlorophenyl)thio)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-((4-(methylthio)phenyl)thio)acetyl)phenyl)-N-ethy!-N-methylformimidamide; N'-(2-chloro-4-(2-((3-chlorophenyl)thio)acetyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-5-methyl-4-(2-((3-(trifluoromethyl)phenyl)thio)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyi-4-(2-(3-((perfluoroethy])thio)phenoxy)acetyl)phenyl)-N-ethyl-N-methylformimidarnide; N'-(2,5-dimethyl-4-(2-(3-((trifluoromethy])thio)phenoxy)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(3-(dimethylamino)phenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformirnidamide; N'-(2,5-dimethyl-4-(2-methy]-2-(m-tolyloxy)propanoyl)pheny])-N-ethyl-N-rnethylforrnimidamide; N'-(2,5-dimethyl-4-(2-(o4olyloxy)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-(3-(trifluoromethyl)phenoxy)acety])phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(3,4-dichlorophenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(2,6-dimethylphenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(2-(tert-butyl)phenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(3,4-dimethylphenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-(m-tolyloxy)propanoyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-(3-((3,4,4-trifluorobut-3-en-l -yl)thio)phenoxy)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-(4-((trifluoromethyl)thio)phenoxy)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(3-bromo-4-methylphenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylforrnimidamide; N'-(4-(2-(2-bromo-4-methylphenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-((2,6-dimethylphenyl)thio)acetyl)-2,5-dimethy]phenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-methy]-2-(m4olylthio)propanoyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(N-(4-chlorophenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidami N'-(2,5-dimethyl-4-(N-methyl-N-phenylglycyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(2,6-dichlorophenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(2,6-dibromophenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(2-biOmo-6-methylphenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidarnide; N'-(4-(2-(2-biOmo-4,6-dimethyIphenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformiiTiidarnide; N'-(4-(2-(2-bromo-5-methylphenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylforrnimidamide; N'-(4-(2-(2-chloro-6-methy]phenoxy)acety])-2,5-dimethy]phenyl)-N-ethy]-N-methylformirnidamide; N'-(2,5-dimethyl-4-(N-methyI-N-(p-tolyl)g]ycyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(2-chloro-4-methylphenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylforrnimidaiTiide; N'-(4-(2-(2,4- dichlorophenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(2,5-dimethylphenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(5-chloro-2-methylphenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylfonTiimidamide; N'-(4-(2-(3,5-dichloiOphenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(4-chloro-3-(trifluoromethyl)phenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(2,3-dimethylphenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methyIformimidamide; N'-(4-(2-((2-chloro-6-methylphenyl)thio)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-((3,5-dichlorophenyl)thio)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-((2,4-difluorophenyl)thio)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide N'-(4-(2-((2,6-difluorophenyl)thio)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide N'-(4-(2-((2-bromophenyl)thio)acetyl)-2-chloro-5-methylphenyl)-N,N-dimethylformimidamide N'-(2,5-dimethyl-4-(2-(3-(methylthio)phenoxy)acetyl)phenyl)-N,N-dimethylformimidamide; N'-(4-(2-((3-fluorophenyl)thio)acetyl)-2,5-dimethylplienyl)-N,N-dimethylformimidamide; N'-(4-(2-((2,6-dimethylphenyl)thio)acetyl)-2,5-dimethylphenyl)-N,N-dimethylforiTiiniidamide; N'-(4-(2-(2-chlorophenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(2-chlorophenoxy)acetyl)-2,5-dimethylphenyl)-N,N-dirnethylformimidamide; N-ethyl-N'-(4-(2-(2-methoxyphenoxy)acetyl)-2,5-dimethylpheny])-N-methylformimidamide; N-ethyl-N'-(4-(2-(3-(ethylthio)phenoxy)acetyl)-2,5-dimethylphenyl)-N-methylformimidamide; N'-(24Dromo-4-(2-((3-fluorophenyl)thio)acetyl)-3,6-dimethylphenyl)-N-ethyl-N-methy]formimidamide; N'-(2,5-dimethyl-4-(2-(3-(trifluoromethoxy)phenoxy)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(4H-l ,2,4-triazol-4-yl)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-(3-(trifluoiOmethoxy)phenoxy)acetyl)phenyl)-N,N-dimethylformimidamide; N'-(4-(2-(benzo[d]thiazol-2-ylthio)acetyl)-2,5-dimethylphenyl)-N,N-dimethylformimidamide; N'-(4-(2-(4H- l ,2,4-triazol-4-yl)acetyl)-2,5-dimethylphenyl)-N,N-dimethylformimidamide; N'-(2,5-dimethyl-4-(2-(4-(trifluoromethyl)phenoxy)acetyl)phenyl)-N,N-dimethylformimidamide; N'-(2-chloro-4-(2-(2,5-dimethylphenoxy)acetyl)-5-methy]phenyl)-N-ethyl-N-methylfonTiimidamide; N'-(4-(2-(2-bromo-4-methylphenoxy)acetyl)-2-chloro-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-(2-(5-chloiO-2-methylphenoxy)acetyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(2-bromo-4-methoxyphenoxy)acetyl)-2-chloro-5-methylphenyl)-N-ethyl-N-methylformimidamide; ; N-ethyl-N'-(4-(3-(4-fluorophenyl)propanoyl)-2,5-dimethylphenyl)-N-methylformimidamide; N'-(4-((2-chloiOphenyl)glycyl)-2,5-dimethylphenyl)-N-ethy!-N-methyIformimidamide; N-ethyl-N'-(2-fluoro-5-methyl-4-(3-(o-tolyl)propanoyl)phenyl)-N-methylformimidamide; N'-(4-((4-chlorophenyl)glycyl)-2,5-dimethylphenyl)-N-ethy!-N-methylformimidamide; N'-(5-chloro-4-(3-(2-fluorophenyl)piOpanoyl)-2- methylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-( l H-benzo[d]imidazol- l -yl)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-(3-(3-fluorophenyl)propanoyl)-5-methylpheny])-N-ethyl-N-methylformimidamide; N'-(4-(2-( l H-indol- l -yl)acetyl)-2, 5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N-ethyl-N'-(5-fluoro-4-(2-((2-fluoiOphenyl)thio)acetyl)-2-methylphenyl)-N-methylformimidamide; N'-(4-(2-( l H-imidazo[4,5-b]pyridin- l -yl)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N-ethyl-N'-(5-fluoiO-4-(2-(3-fluorophenoxy)acetyl)-2-methylphenyl)-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-(3-methyl- l H-pyrrol- l -yl)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N-ethyl-N'-(5-fluoro-4-(2-((4-fluorophenyl)thio)acetyl)-2-methylphenyl)-N-methylformimidamide; N'-(4-(2-(2H-isoindol-2-yl)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N-ethyl-N'-(5-fluoro-4-(2-((2-fluoro-6-methylphenyl)thio)acetyl)-2-methylphenyl)-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-(2-oxopyridin- l (2H)-yl)acetyl)phenyl)-N-ethyl-N-methy]formimidamide; N-ethyl-N'-(5-fluoro-4-(N-(2-f]uorophenyl)-N-methylglycy])-2-methylphenyl)-N-methylformimidamide; N'-(4-(2-( l H-pyrazol- l -yl)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N-ethyl-N'-(5-fluoro-4-(N-(3-fluorophenyl)-N-methylglycyl)-2-methylphenyl)-N-methylformirnidamide; N'-(2,5-dimethyl-4-(2-(4,5,6,7-tetrahydro- l H-indazol- l -yl)acetyl)phenyl)-N-ethyl-N-methylfonTiimidarnide; N-ethyl-N'-(5-fluoro-4-(N-(4-fluorophenyl)-N-methylglycyl)-2-methylphenyl)-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-(4,5,6,7-tetrahydro- 1 H-indol- 1 -yl)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N-ethyl-N'-(5-fluoro-4-(N-(2-fluoiO-6-methylphenyl)-N-methyIglycyl)-2-methylphenyl)-N-methylformimidamide; N'-(2,5-dimethyl-4-(2-(4,5,6,7-tetrahydro-2H-isoindol-2-yl)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N-ethyl-N'-(2-fluoro-4-(N-(2-fluorophenyl)-N-methylglycyl)-5-methylphenyl)-N-methylformimidamide; N'-(4-(2-(benzo[d]thiazol-3(2H)-yl)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N-ethyl-N'-(2-fluoro-4-(N-(3-fluorophenyl)-N-methylglycyl)-5-methylphenyl)-N-methylformimidamide; N-ethyl-N'-(4-(2-(3-fluorophenoxy)- l -(methylimino)ethyl)-2,5-dirnethylphenyl)-N-methylforrnirnidamide; N-ethyl-N'-(2-fluoro-4-(N-(4-fluorophenyl)-N-methylglycyl)-5-methylphenyl)-N-methylformimidamide; N-ethyl-N'-(4-(2-(4-methoxyphenoxy)- l -(methyl imino)ethyl)-2,5-dimethylphenyl)-N-methylformirnidamide; N-ethyl-N'-(2-fluoro-4-(N-(2-fluoro-6-methylphenyl)-N-methylglycyl)-5-methylphenyl)-N-methylformimidam N'-(4-(2-((3,4-dimethylphenyl)thio)- l -(methylimino)ethyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(5-chloro-4-(N-(2-fluorophenyl)-N-methylglycyl)-2-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-( l -(methylimino)-2-(m-tolyloxy)ethyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(5-chloro-4-(N-(3-fluorophenyl)-N-methylglycyl)-2-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(3-chlorophenoxy)- l -(methylimino)ethyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(5-chloiO-4-(N-(4-fluorophenyl)-N-methylglycyl)-2-methylphenyl)-N-ethyl- N-methylformimidamide; N'-(2,5-dimethyl-4-( 1 -(methylimino)-2-(4- (trifluoromethoxy)phenoxy)ethyi)phenyl)-N-ethyl-N-methylformimidamide; N'-(5-chloro-4-(N-(2-fluoiO-6-methylphenyl)-N-methylglycyl)-2-methylphenyI)-N-ethyl-N-methylformimidamide; N'-(2,5-dimediyl-4-( l -(methylimino)-2-(p-tolyloxy)ethyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(2-Fluoro-4-((2-fluorophenyl)glycyl)-5-methylphenyl)-N-ethyl-N-methylforrniiTiidarnide; N'-(4-(2-(4-chlorophenoxy)-l -(methylimino)ethyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-Fluoro-4-((3-fluoiOphenyl)glycy])-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-( ] - (methylimino)-2-(3-(methylthio)phenoxy)ethyl)phenyI)-N-ethyl-N-methylformimidarnide; N'-(2-Fluoro-4-((4-fluorophenyl)glycyl)-5-methyIphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)- l -(methylimino)ethyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-Fluoro-4-((2-fluoiO-6-methylphenyl)glycyl)-5-methy]phenyl)-N-ethyl-N-methylformimidamide; N'-(2-chIoro-5-inethyl-4-( l -(methylimino)-2-phenoxyethyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloiO-4-((2-fluoiOphenyl)glycyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloiO-4-(2-(3-chlorophenoxy)- l -(methylimino)ethyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-((3-fluorophenyl)glycyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloiO-4-(2-(4-chlorophenoxy)- l -(methylimino)ethyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-((4-fluorophenyl)glycyl)-5-methylphenyl)-N-ethy]-N-methylformimidamide; N'-(4-(2-((4-biOmopheny])thio)- l -(methylimino)ethyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-((2-fluoro-6-methylphenyl)glycyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(3-bromophenoxy)-l -(methylimino)ethyl)-2-chloro-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-(N-(2-fluorophenyl)-N-methylglycyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-(2-(3-fluorophenoxy)- l -(methylimino)ethyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-(N-(3-fluorophenyl)-N-methylglycyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-5-methyl-4-( l -(methylimino)-2-(p4olyloxy)ethyl)phenyl)-N-ethyl-N-methylforrnimidamide; N'-(2-chloro-4-(N-(4-fluoropheny])-N-methylglycyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-5Hnethyl-4-( ] -(methylimino)-2-(m4o]yloxy)ethyl)phenyl)-N-ethy]-N-methylformimi N'-(2-chloro-4-(N-(2-fluoro-6-methylphenyl)-N-methylglycyl)-5-methylphenyl)-N-ethyl-N-methylformimidamide; N-ethyl-N'-(4-(2-((3-methoxyphenyl)thio)-l -(methylimino)ethyl)-2,5-dimethylphenyI)-N-methylformimidamide; N-ethyl-N'-(4-(N-(2-fluorophenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-methylformimidamide; N-ethyl-N'-(4-(2-((4-fluorophenyl)thio)- l -(methylimino)ethyl)-2,5-dimethylphenyl)-N-methylformimidamide; N-ethyI-N'-(4-(N-(3-fluorophenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-methylformimidamide; N'-(4-(2-((4-chlorophenyl)thio)- l -(methylimino)ethyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N-ethyl-N'-(4-(N-(4- fluorophenyl)-N-methylgIycyl)-2,5-dimethylphenyl)-N-methyiformimidamide; N'-(4-(2-((2-bromophenyl)thio)-r^methylimino)ethyl)-2,5-dimethyIphenyl)-N-ethyl-N-methylfomii N-ethyl-N'-(4-(N-(2-fluoro-6-methylphenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-methylformimidamide; N'-(4-(2-(2-bromophenoxy)- l -(methylimino)ethyl)-2-chloro-5-methy]phenyl)-N-ethyl-N-methylformimidamide; N-ethyl-N'-(4-(N-(5-flluotO-2-methylphenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-methylformimidamide; N-ethyl-N'-(4-(2-(2-f!uoiOphenoxy)- l -(methylimino)ethyl)-2,5-dimethylphenyl)-N-methy]formimidamide; N-ethyl-N'-(4-(N-(4-fluoro-2-methylphenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-methylformiiTiidamide; N-ethyl-N'-(4-(2-(4-fluorophenoxy)-l -(methylimino)ethyl)-2,5-dimethylphenyl)-N-methylformimidamide; N-ethyl-N'-(4-(N-(3-fluoro-2-methylphenyl)-N-methylglycyl)-2,5-dimethylphenyI)-N-methylformimidamide; N'-(4-(2-(2-bromophenoxy)-l-(methylimino)ethyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(N-(2-chloro-6-fluorophenyl)-N-methylglycyl)-2,5-dimethylphenyI)-N-ethyl-N-methylformimidarnide; N'-(2-chloro-5-methyl-4-(l -(methylimino) N-ethyl-N'-(4-(N-(3-fluoro-4-methylphenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-methylformimidamide; N'-(4-(2-((3-bromophenyl)thio)- l -(methylimino)ethyl)-2-chloro-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(N-(4-chloro-3-fluorophenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-((Z)-2-((3-fluorophenyl)thio)-l -(methylimino)ethyl)-5-methylphenyl)-N-ethyl-N-methylforrnimidamide; N'-(4-(N-(2-chloro-5-fluorophenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2-chloro-4-((Z)-2-((4-chlorophenyl)thio)- l -(methylimino)ethyl)-5-methylphenyl)-N-ethyl-N-methylformi N'-(4-(N-(2-chloro-4-fluorophenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-((Z)-2-((2-bromophenyl)thio)- l -(methylimino)ethyl)-2-chloro-5-methylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(N-(2-chloro-3-fluorophenyl)-N-methylgIycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-( l -(m-tolyloxy)cyclopropane- 1 - carbonyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(N-(4-bromo-3-fluorophenyl)-N-methylglycyl)-2,5-dirnethylphenyl)-N-ethyl-N-methylformimidarnide; N'-(2,5-dimethyl-4-( l -(o-tolyloxy)cyclopropane-l -carbonyl)phenyl)-N-ethyl-N-methylformimidarnide; N'-(4-(N-(4-bromo-2-methylphenyl)-N-methylglycyl)-2,5-dimethylphenyI)-N-ethyl-N-methylformiiTiidarnide; N'-(4-(2-cyano- 2- ((2,6-dimethylphenyl)thio)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylfonriimi N'-(4-(N-(4-bromo-2-fluorophenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidami N'-(4-(2-cyano-2-(m4olylthio)propanoyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(N-(2,4-difluorophenyl)-N-methylglycyl)-2,5-dimethylphenyI)-N-ethyl-N-methylformimidamide; N'-(4-(2-((4-chlorophenyl)(methyl)amino)-2-cyanoacetyl)-2,5-dimethylphenyl)-N-ethy]-N-methy]formimi NX4-(N-(2,6-difluorophenyl)-N-methyIglycyl)-2,5-dimethylphenyI)-N-ethyl-N-methylformimidami N'-(4-(2-cyano-2-(methyl(phenyl)amino)acetyl)-2,5-dimethylphenyl)-N-ethyI-N-methylformimidai^ N'-(4-(N-(3,4-difluorophenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-cyano-2-(2,6-dichlorophenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidam N'-(4-(N-(3,5-difluorophenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-cyano-2-(2,6-dibromophenoxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(N-(3,5-dimethoxyphenyl)-N-methylglycyl)-2,5-dimethyIphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(2-biOmo-6-methylphenoxy)-2-cyanoacetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(N-(3-chloro-5-methoxyphenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(dimethylamino)-2-(p-tolyloxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(N-(5-chloro-2-methoxyphenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidaiTiide; N'-(4-(2-(dimethylamino)-2-(m-toIyloxy)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(N-(3-chloro-2-methoxyphenyl)-N-methylglycy])-2,5-dimethyIphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-(dimethylamino)-2-phenoxyacetyl)-2,5-dimethylphenyl)-N-ethyi-N-methylformimidamide; N'-(4-(N-(3-chloro-4-methoxyphenyl)-N-methylglycyl)-2,5-dim N'-(2,5-dimethyl-4-(2-methyl-2-(phenylamino)propanoy])phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(N-(3-chlorophenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-( l -(methyl(phenyl)amino)cyclopropane- l -carbonyl)phenyl)-N-ethyl-N-methylformimidamide N'-(4-(N-(2-chlorophenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide N'-(2, 5-dimethyl-4-( 1 -phenoxycyclopropane- 1 -carbonyl)phenyl)-N-ethyl-N-methylformimidamide N'-(4-(N-(4-chlorophenyl)-N-methylglycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide N'-(2,5-dimethyl-4-(2-methyl-2-phenoxypropanoyl)phenyl)-N-ethyl-N-methylformimidamide N-ethyl-N'-(4-((3-fluorophenyl)glycyl)-2,5-dimethylphenyl)-N-methylformimidamide N'-(4-(2,2-difluoro-2-phenoxyacetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide N-ethyl-N'-(4-((2-fluorophenyl)glycyl)-2,5-dimethylphenyl)-N-methylformimidamide N'-(4-(2-(4-chlorophenoxy)-2,2-difluoroacetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide N-ethyl-N'-(4-((4-fluoiOphenyl)glycyl)-2,5-dimethylphenyl)-N-methylformimidamide N-ethyl-N'-(4-(2-fluoiO-2-phenoxyacetyl)-2,5-dimethylphenyl)-N-methylformimidamide N-ethyl-N'-(4-((2-fluoro-6-methylphenyl)glycyl)-2,5-dimethylphenyl)-N-methylformimidamide N'-(4-(2,2-difluoro-2-(phenylthio)acetyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide N-ethyl-N'-(4-((4-fluoro-2-methylphenyl)glycyl)-2,5-dimethylphenyl)-N-methylformimidamide N'-(4-( l , l -difluoro-3-phenoxyprop- l -en-2-yl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide: N-ethyl-N'-(4-((3-fluoiO-2-methylphenyl)glycyl)-2,5-dimethylphenyl)-N-methylformimidamide: N'-(4-( l , l -difluoro-3-(phenylthio)prop- l -en-2-yl)-2,5-dimethylphenyl)-N-ethyl- N-methylformimidamide; N-ethyl-N'-(4-((3-fluoro-4-methylphenyl)glycyl)-2,5-dimethyIphenyl)-N-methylformimidamide; N-ethyl-N'-(4-(2-(2-fluorophenoxy)ethanethioyl)-2,5-dimethylphenyl)-N-methylformimidamide: N-ethyl-N'-(4-((5-fluoro-2-methylphenyl)glycyl)-2,5-dimethylphenyl)-N-methylformimidamide: N'-(2,5-dimethyl-4-(2-(o-tolyloxy)ethanethioyI)phenyl)-N-ethyl-N-methylformimidamide: N'-(4-((2-chloro-6-fluorophenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide: N'-(4-(2-(2-bromophenoxy)ethanethioyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide: N'-(4-((2-chloro-5-fluorophenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide: N'-(4-(2-((4-bromo-2-methylphenyl)amino)ethanethioyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-((2-chloro-4-fluorophenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-((4-bromo-2-fluorophenyl)amino)ethanethioyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-((2-chloro-3-fluorophenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-((2,4-difluorophenyl)amino)ethanethioyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-((4-chloro-3-fluorophenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-((2,6-difluorophenyl)amino)ethanethioyI)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-((4-bromo-3-fluorophenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(2-((3,4-difluorophenyl)amino)ethanethioyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-((4-bromo-2-methylphenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide N'-(2-(2-((3-chlorophenyl)thio)acetyl)-4-methylpyrimidin-5-yl)-N-ethyl-N-methylformimidamide: N'-(4-((4-bromo-2-fluorophenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide N-ethyl-N'-(2-(2-(3-fluorophenoxy)acetyl)-4-methylpyrimidin-5-yl)-N-methylformimidamide: N'-(4-((2,4-difluorophenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide N-ethyl-N'-(2-(2-((4-fluorophenyl)thio)acetyl)-4-methylpyrimidin-5-yl)-N-methylformimidamide N'-(4-((2,6-difluorophenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide N'-(5-chloro-6-(2-((3-chlorophenyl)thio)acetyl)-2-methylpyridin-3-yl)-N-ethyl-N-methylformimidamide N'-(4-((3,4-difluorophenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide N'-(5-chloro-2-methyl-6-(2-(3-(methylthio)phenoxy)acetyl)pyridin-3-yl)-N-ethyl-N-methylformimidamide; N'-(4-((3,5-difluorophenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(5-chloro-2-methyl-6-(2-(4-(trifluoromethoxy)phenoxy)acetyl)pyridin-3-yl)-N-ethyl-N-methylformimidamide; N'-(4-((3,5-dimethoxyphenyl)glycyl)-2,5-dimethylphenyl)-N-ethy!-N-methylformimidamide N'-(5-chloro-6-(2-((4-fluorophenyl)thio)acetyl)-2-methylpyridin-3-yl)-N-ethyl-N-methylformimidamide N'-(4-((3-chloro-5-methoxyphenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide. N'-(5-chloro-2-methyl-6-(2-(phenylthio)acetyl)pyridin-3-yl)-N-ethyl-N-methylformimidamide N'-(4-((5-chloro-2-methoxyphenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide. N'-(2,5-dimethyl-6-(2-(phenylthio)acetyl)pyridin-3-yl)-N-ethyl-N- methylformimidamide; N'-(4-((3-chloro-2-methoxyphenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; l -(5-chloro-2-methyl-4-(( l -methylpyn lidin-2-ylidene)amino)phenyl)-2-(3-chlorophenoxy)ethan- l -one;N'-(4-((3-chloro-4-methoxyphenyl)glycyl)-2,5-dimethylphenyl)-N-ethy]-N-methylformimidamide; l -(5-chloro-2-methyl-4-(( l -methylpyrrolidin-2-ylidene)amino)phenyl)-2-(4-chIorophenoxy)ethan- l -one;N'-(4-((3-chlorophenyl)glycyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; l -(5-chloro-2-methyl-4-(( l -methylpyrrolidin-2-ylidene)amino)phenyl)-2-(3-fluorophenoxy)ethan- l -one; l -(5-chloro-2-methyl-4-(( l -methylpyrrolidin-2-ylidene)amino)phenyl)-2-((4-chlorophenyl)thio)ethan- l -one; N'-(2,5-dimethyl-4-(2-(piperidin-l -yl)acetyl)phenyl)-N-ethyl-N-methylformimidamide; 2-((4-bromophenyl)thio)- l -(2,5-dimethyl-4-(( l -methylpyrrolidin-2-yIidene)amino)phenyl)ethan- l -one; N-ethyl-N'-(4-(2-(isoindolin-2-yl)acetyl)-2,5-dimethylphenyl)-N-methylformimidamide; l -(5-chloro-2-methyl-4-(( l -methylpyrrolidin-2-ylidene)amino)phenyl)-2-((3-fluorophenyl)thio)ethan-l -one; N'-(2,5-dimethyl-4-(2-(l -oxoisoindolin-2-yl)acetyl)phenyl)-N-ethyl-N-methylformimidamide; N'-(2,5-dimethyl-4-(3-methyl-l -(methyl(phenyl)amino)but-2-en-2-yl)phenyl)-N-ethyl-N-methylformimidamide; N'-(4-(3-((2,6-difiuorophenyl)thio)- l , l -difluoroprop- l -en-2-yl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(3-((2,6-difluorophenyl)(methyl)amino)prop- l -en-2-yl)-2,5-dimethylphenyl)-N-ethyl-N-methylformimidamide; N'-(4-(3-((2-bromophenyl)thio)-l , l -difluoroprop-l -en-2-yl)-2-chloro-5-methylphenyl)-N,N-dimethylformimidamide; 5. The compounds of general formula (I) according to claim 1 , in a composition with one or more inert carriers for controlling or preventing phytopathogenic microorganisms. 6. The compounds of general formula (I) according to the claim 1 in a composition comprising one or more active compatible compounds selected from fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, plant growth regulators, antibiotics, fertilizers and or mixtures thereof. 7. The compounds of general formula (I) according to the claim 1 in a composition, wherein the concentration of compounds having general formula (I) ranges from 1 to 90% by weight with respect to the total weight of the composition, preferably from 5 to 50% by weight with respect to the total weight of the composition. 8. Use of the compounds of general formula (1) according to claim 1 or its composition according to claim 6 for the control of phytopathogenic fungi, bacteria, insects, nematodes, mites of agricultural crops and or horticultural crops. 9. Use of the compounds of general formula (I) according to claim 1 for controlling or preventing against phytopathogenic fungi of agricultural crops and or horticultural crops. 10. Use of compounds of general formula (1) according to claim 1 , or compositions according to claim 5, for controll ing rust diseases of different crops. 1 1 . Use of compounds of general formula (I) according to claim 1 , or compositions according to claim 5, wherein the rust diseases of crops are Hemileia vastatrix (Coffee rust), Uromyces appendiculatus/fabae/ phaseoli (rust of beans) Piiccinia spp. (rusts) on various plants, selected from P. triticina (brown or leaf rust), P. striiformis (stripe or yellow rust), Puccinia melanocephala (sugarcane rust), P. hordei (dwarf rust), P. graminis (stem or black rust) or P. recondita (brown or leaf rust), on cereals, selected from wheat, barley or rye and Phakopsora spp. on various plants, in particular Phakopsora pachyrhizi and P. meibomiae (soybean rust) on soybeans. 12. Use of compounds of general formula (I) according to claim 1 , or compositions according to claim 5, for controlling or preventing against phytopathogenic fungi selected from Phakopsora pachyrhizi, Phakopsora meibomiae, of agricultural crops and or horticultural crops. 13. Use of the compounds of general formula (I) according to claim 1 , wherein the agricultural crops are cereals, corn, rice, soybean and other leguminous plants, fruits and fruit trees, nuts and nut trees, citrus and citrus trees, horticultural plants, cucurbitaceae, oleaginous plants, tobacco, coffee, tea, cacao, sugar beet, sugar cane, cotton, potato, tomato, onions, peppers and other vegetables, and ornamentals. 14. A method of controlling or preventing infestation of useful plants by phytopathogenic microorganisms in agricultural crops and or horticultural crops wherein the compounds of general formula (I) according to claim 1 is applied to the plants, to parts thereof or the locus thereof. 15. A method of controlling or preventing infestation of useful plants by phytopathogenic microorganisms in agricultural crops and or horticultural crops wherein the compounds of general formula (I) according to claim 1 is appl ied to the seeds of plants. 16. A method of controlling or preventing phytopathogenic microorganisms in agricultural crops and or horticultural crops using the compounds of general formula (I) according to claim 1 or compositions according to claim 5, which consists in applying effective dosages of compounds or compositions in amounts ranging from 1 g to 5 kg per hectare of agricultural or horticultural crops.

Documents

Application Documents

# Name Date
1 201917042008-RELEVANT DOCUMENTS [27-09-2023(online)].pdf 2023-09-27
1 201917042008.pdf 2019-10-17
2 201917042008-IntimationOfGrant06-02-2023.pdf 2023-02-06
2 201917042008-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [17-10-2019(online)].pdf 2019-10-17
3 201917042008-STATEMENT OF UNDERTAKING (FORM 3) [17-10-2019(online)].pdf 2019-10-17
3 201917042008-PatentCertificate06-02-2023.pdf 2023-02-06
4 201917042008-Written submissions and relevant documents [01-09-2022(online)].pdf 2022-09-01
4 201917042008-PRIORITY DOCUMENTS [17-10-2019(online)].pdf 2019-10-17
5 201917042008-FORM 1 [17-10-2019(online)].pdf 2019-10-17
5 201917042008-Correspondence to notify the Controller [12-08-2022(online)].pdf 2022-08-12
6 201917042008-US(14)-ExtendedHearingNotice-(HearingDate-17-08-2022).pdf 2022-07-21
6 201917042008-FIGURE OF ABSTRACT [17-10-2019(online)].pdf 2019-10-17
7 201917042008-DECLARATION OF INVENTORSHIP (FORM 5) [17-10-2019(online)].pdf 2019-10-17
7 201917042008-Correspondence to notify the Controller [05-07-2022(online)].pdf 2022-07-05
8 201917042008-FORM-26 [05-07-2022(online)].pdf 2022-07-05
8 201917042008-COMPLETE SPECIFICATION [17-10-2019(online)].pdf 2019-10-17
9 201917042008-FORM 3 [27-01-2020(online)].pdf 2020-01-27
9 201917042008-US(14)-HearingNotice-(HearingDate-12-07-2022).pdf 2022-06-01
10 201917042008-FORM 3 [18-03-2021(online)].pdf 2021-03-18
10 201917042008-FORM 3 [18-05-2022(online)].pdf 2022-05-18
11 201917042008-FER.pdf 2021-10-18
11 201917042008-FORM 18 [18-03-2021(online)].pdf 2021-03-18
12 201917042008-ABSTRACT [23-09-2021(online)].pdf 2021-09-23
12 201917042008-FORM-26 [09-08-2021(online)].pdf 2021-08-09
13 201917042008-CLAIMS [23-09-2021(online)].pdf 2021-09-23
13 201917042008-Proof of Right [23-09-2021(online)].pdf 2021-09-23
14 201917042008-COMPLETE SPECIFICATION [23-09-2021(online)].pdf 2021-09-23
14 201917042008-PETITION UNDER RULE 137 [23-09-2021(online)].pdf 2021-09-23
15 201917042008-FER_SER_REPLY [23-09-2021(online)].pdf 2021-09-23
15 201917042008-FORM 3 [23-09-2021(online)].pdf 2021-09-23
16 201917042008-FER_SER_REPLY [23-09-2021(online)].pdf 2021-09-23
16 201917042008-FORM 3 [23-09-2021(online)].pdf 2021-09-23
17 201917042008-PETITION UNDER RULE 137 [23-09-2021(online)].pdf 2021-09-23
17 201917042008-COMPLETE SPECIFICATION [23-09-2021(online)].pdf 2021-09-23
18 201917042008-CLAIMS [23-09-2021(online)].pdf 2021-09-23
18 201917042008-Proof of Right [23-09-2021(online)].pdf 2021-09-23
19 201917042008-ABSTRACT [23-09-2021(online)].pdf 2021-09-23
19 201917042008-FORM-26 [09-08-2021(online)].pdf 2021-08-09
20 201917042008-FER.pdf 2021-10-18
20 201917042008-FORM 18 [18-03-2021(online)].pdf 2021-03-18
21 201917042008-FORM 3 [18-03-2021(online)].pdf 2021-03-18
21 201917042008-FORM 3 [18-05-2022(online)].pdf 2022-05-18
22 201917042008-FORM 3 [27-01-2020(online)].pdf 2020-01-27
22 201917042008-US(14)-HearingNotice-(HearingDate-12-07-2022).pdf 2022-06-01
23 201917042008-COMPLETE SPECIFICATION [17-10-2019(online)].pdf 2019-10-17
23 201917042008-FORM-26 [05-07-2022(online)].pdf 2022-07-05
24 201917042008-DECLARATION OF INVENTORSHIP (FORM 5) [17-10-2019(online)].pdf 2019-10-17
24 201917042008-Correspondence to notify the Controller [05-07-2022(online)].pdf 2022-07-05
25 201917042008-US(14)-ExtendedHearingNotice-(HearingDate-17-08-2022).pdf 2022-07-21
25 201917042008-FIGURE OF ABSTRACT [17-10-2019(online)].pdf 2019-10-17
26 201917042008-FORM 1 [17-10-2019(online)].pdf 2019-10-17
26 201917042008-Correspondence to notify the Controller [12-08-2022(online)].pdf 2022-08-12
27 201917042008-Written submissions and relevant documents [01-09-2022(online)].pdf 2022-09-01
27 201917042008-PRIORITY DOCUMENTS [17-10-2019(online)].pdf 2019-10-17
28 201917042008-STATEMENT OF UNDERTAKING (FORM 3) [17-10-2019(online)].pdf 2019-10-17
28 201917042008-PatentCertificate06-02-2023.pdf 2023-02-06
29 201917042008-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [17-10-2019(online)].pdf 2019-10-17
29 201917042008-IntimationOfGrant06-02-2023.pdf 2023-02-06
30 201917042008.pdf 2019-10-17
30 201917042008-RELEVANT DOCUMENTS [27-09-2023(online)].pdf 2023-09-27

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1 SearchStrategy_201917042008E_26-03-2021.pdf

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