We Claims:
1. A process for the preparation of 5-chloro-N4-[2-[(l-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(l -methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine compound of formula-1, comprising of:
a) Reacting l-chloro-5-isopropoxy-2-methyl-4-nitrobenzene compound of formula-24 with pyridin-4-ylboronic acid in presence of suitable palladium catalyst and a suitable base in a suitable solvent to provide 4-(5-isopropoxy-2-methyl-4-nitrophenyl)pyridine compound of formula-25,
b) optionally purifying the compound of formula-25 using a suitable solvent,
c) reduction of compound of formula-25 with a suitable reducing agent in a suitable solvent to provide 2-isopropoxy-5-methyl-4-(piperidin-4-yl)aniline compound of formula-21,
d) treating the compound of formula-21 with a suitable hydrochloric acid source in a suitable solvent to provide 2-isopropoxy-5-methyl-4-(piperidin-4-yl)aniline hydro chloride salt hydrate compound of general formula-21,
e) reacting the compound of general formula-21 with a suitable amino protecting agent in presence of a suitable base in a suitable solvent to provide N,N'-protected 2-isopropoxy-5-methyl-4-(piperidin-4-yl)aniline compound of general fromula-19,
f) optionally treating the compound of general formula-19 with a suitable acid in a suitable solvent to provide its corresponding acid addition salts of N,N'-protected 2-isopropoxy-5-methyl-4-(piperidin-4-yl)aniline compound of general formula-19,
g) reacting compound of general formula-19 or its acid addition salt with 2,5-dichloro-N-(2-(isopropylsulfonyl) phenyl)pyrimidin-4-amine compound of formula-4 in presence of a suitable acid source in a suitable solvent to provide N-protected acid addition salt of compound of general formula-7,
h) reacting the acid addition salt of compound of general formula-7 with a suitable acid in a suitable solvent to provide corresponding acid addition salt of 5-chloro-N4-[2-[(l-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(l-methyl ethoxy)-4-(4-piperidinyl) phenyl]-2,4-pyrimidinediamine compound of formula-1,
i) treating the acid addition salt compound of formula-1 with a suitable base in a suitable

solvent to provide compound of formula-1.
2. The process as claimed in claim-1, wherein, in step-a) the suitable palladium catalyst is selected from the group consisting of tetrakis(triphenylphosphine)palladium(0), tetrakiss(tri(tolyl)phosphine) palladium(O), palladium acetate (Pd(OAc)2), Tris(dibenzyli deneacetone)dipalladium (Pd2dba3), [1,1 'Bis(diphenylphosphino)ferrocene]dichloro palladium (Pd(dppf)Cl2), Bis(triphenylphosphine)palladium (II) dichloride (PdCb (PPh3)2), trans-bis(benzonitrile) palladium (II) dichloride (Pd(PhCN)2Cl2) and mixtures thereof and the suitable base is selected from organic base or inorganic base; in step-c) the suitable reducing agent is selected from Pd/C, Fe, Fe in acidic media like NH4C1, ammonium acetate or HC1 or acetic acid, Sn in acidic media like HC1, Zn dust, Zn in acidic media like HC1 or NH4CI, ammonium acetate or acetic acid, stannous chloride (SnCb), NaBFLi, LiAlFLi, LiBFLi, diborane, borane-THF complex, hydrazine hydrate, hydrogenation catalysts such as Rhodium, sulfides, alkali metal dithionite, alkali metal dithionate and sodium amalgam; in step-d) the suitable hydrochloric acid source which is selected from hydrochloric acid source is selected from HC1 gas, aqueous HC1, dry HC1, ethyl acetate-HCl, IPA-HC1, ethanol-HCl, methanol-HCl;
in step-e) the suitable amino protecting group is selected from benzyloxycarbonyl (Cbz), 2,2,2-trichloroethoxycarbonyl (Troc), 2-(trimethylsilyl)ethoxy carbonyl (Teoc), 2-(4-trifluoro methylphenylsulfonyl)ethoxycarbonyl (Tsc), t-butoxy carbonyl (BOC), 2-tetrahydropyranyl (TUP), l-(ethoxy)ethyl, p-methoxybenzyl, Acetyl (Ac) group, Benzoyl (Bz) group, Benzyl (Bn) group, p-methoxybenzyl (PMB), 3,4-Dimethoxybenzyl (DMPM) and vinylethyl ether; -C(0)OCi-C6 alkyl, such as, for example, carboethoxy, carbomethoxy and t-butoxycarbonyl; optionally substituted -C(0)OCi-C6 aryl, such as, for example, benzyloxy- carbonyl and p-methoxybenzyloxycarbonyl; benzyl, phenethyl, p-methoxy benzyl, 2,3-dimethoxybenzyl, 2,4-dimethoxybenzyl and 9-fluorenylmethyl; benzoyl; C1-C6 alkanoyl, such as, for example, formyl and propionyl; C1-C6 alkylsulfonyl, such as, for example, mesyl; substituted phenyl sulfonyl, such as, for example, benzenesulfonyl, toluenesulfonyl (tosyl) and 3-nitrobenzenesulfonyl; -C1-C6 alkylcarbamoyl, such as for example-dimethyl carbamoyl; and optionally substituted -C7-C10 arylalkyl carbamoyl, such as, for example, benzyl carbamoyl and suitable base is

selected from inorganic base or organic base;
in step-f), step-g) & step h) the suitable acid is selected from inorganic acids such as hydrochloric acid, hydro bromic acid, sulfuric acid, nitric acid or phosphoric acid; and organic acids such as oxalic acid, maleic acid, malonic acid, tartaric acid, fumaric acid, citric acid, malic acid, succinic acid, mandelic acid, lactic acid, acetic acid, propionic acid, 2-chloromandelate, p-toluene sulfonic acid, ethane-1,2-disulfonic acid, camphor sulfonic acid, ethane sulfonic acid, methane sulfonic acid, naphthalene-2-sulfonic acid, benzene sulfonic acid, adipic acid, glutaric acid, glutamic acid, palmitic acid or aspartic acid; suitable acid source is selected from ethyl acetate-HCl, IPA-HC1, ethanol-HCl, methanol-HC1; in step-i) the suitable base is selected from organic or inorganic base; in step-a) to step-j) the suitable solvent is selected from hydrocarbon solvents, ketone solvents, ester solvents, chloro solvents, nitrile solvents, alcohol solvents, ether solvents, polar aprotic solvents and polar solvents like water and mixture thereof.
. The process as claimed in claim-1 & 2, wherein, a process for the preparation of 5-chloro-N4-[2-[(l-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(l-methylethoxy)-4-(4-piperidinyl) phenyl]-2,4-pyrimidinediamine compound of formula-1, comprising of:
a) Reacting l-chloro-5-isopropoxy-2-methyl-4-nitrobenzene compound of formula-24 with pyridin-4-ylboronic acid in presence of bis(triphenylphosphine)palladium (II) dichloride and potassium carbonate in a mixture of water and 2-butanol to provide 4-(5-isopropoxy-2-methyl-4-nitrophenyl)pyridine compound of formula-25,
b) purifying the compound of formula-25 using a mixture of isopropanol and n-heptane,
c) reducing the compound of formula-25 with Pd/C in presence of acetic acid in isopropanol to provide 2-isopropoxy-5-methyl-4-(piperidin-4-yl)aniline compound of formula-21,
d) treating the compound of formula-21 with isopropanolic hydrochloric acid in methyl tert-butyl ether to provide 2-isopropoxy-5-methyl-4-(piperidin-4-yl)aniline hydrochloride salt monohydrate compound of formula-21 a,
e) reacting the compound of formula-21 a with acetic anhydride in presence of triethyl amine in dichloromethane to provide N-(4-(l-acetylpiperidin-4-yl)-2-isopropoxy-5-methylphenyl) acetamide compound of formula-19a,
f) treating the compound of formula-19a with isopropanolic HC1 in a mixture of

isopropanol and methyl tert-butyl ether to provide N-(4-(l-acetylpiperidin-4-yl)-2-isopropoxy-5-methylphenyl)acetamide hydrochloride salt compound of formula-19a,
g) reacting the compound of formula-19a with 2,5-dichloro-N-(2-(isopropylsulfonyl) phenyl)pyrimidin-4-amine compound of formula-4 in presence of isopropanolic hydrochloric acid in isopropanol to provide l-(4-(4-(5-chloro-4-(2-(isopropylsulfonyl) phenylamino)pyrimidin-2-ylamino)-5-isopropoxy-2-methylphenyl)piperidin-l-yl) ethanone hydrochloride salt compound of formula-7a
h) reacting the compound of formula-7a with isopropanolic hydrochloric acid in isopropanol to provide 5-chloro-N4-[2-[(l-methylethyl) sulfonyl]phenyl]-N2-[5-methyl-2-(l-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine dihydrochloride salt compound of formula-Id followed by purifying the compound of formula-Id using a mixture of isopropanol and water and then followed by dimethyl formamide to provide pure compound of formula-Id,
i) treating the compound of formula-Id with aqueous sodium hydroxide in a mixture of water, acetone and dichloromethane to provide compound of formula-1,
j) dissolving the compound of formula-1 in dichloromethane and adding the reaction mixture to a pre-cooled n-heptane and then followed by purifying the obtained compound using n-heptane to provide 5-chloro-N4-[2-[(l-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(l -methyl ethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine compound of formula-1.
4. A process for the preparation of 5-chloro-N4-[2-[(l-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(l-methyl ethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine compound of formula-1, comprising of:
a) Reduction of l-chloro-5-isopropoxy-2-methyl-4-nitrobenzene compound of formula-2 with a suitable reducing agent in a suitable solvent to provide 4-chloro-2-isopropoxy-5-methylaniline compound of formula-3,
b) reacting the compound of formula-3 with 2,5-dichloro-N-(2-(isopropyl sulfonyl) phenyl)pyrimidin-4-amine compound of formula-4 in presence of a suitable acid source in a suitable solvent to provide 5-chloro-N2-(4-chloro-2-isopropoxy-5-methyl phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine compound of

formula-5,
c) reacting the compound of formula-5 with N-protected piperidine compound of general formula-6 in the presence of a suitable acid source or palladium catalyst and a suitable base in a suitable solvent to provide acid addition salts of N-protected 5-chloro-N4-[2-[(l-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(l-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine compound of general formula-7,
d) reacting the compound of general formula-7 with a suitable acid in a suitable solvent to provide corresponding acid addition salt of 5-chloro-N4-[2-[(l-methylethyl) sulfonyl]phenyl]-N2-[5-methyl-2-(l-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine compound of formula-1,
e) treating the acid addition salt compound of formula-1 with a suitable base in a suitable solvent to provide compound of formula-1.

5. The process as claimed in claim-4, wherein, in step-a) the suitable reducing agents is same as defined in step-c) of the first aspect of the present invention; in step-b) the suitable acid is ethyl acetate-HCl, IPA-HC1, ethanol-HCl, methanol-HCl; in step-c) the suitable palladium catalyst is same as defined in step-a) of the first aspect of the present invention and the suitable base is selected from inorganic base or organic base; in step-d) the suitable acid is selected from trifluoroacetic acid, methanesulfonic acid, p-toluene sulfonic acid, acetyl chloride and tri(Ci-C6 alkyl)silylhalides, ethyl acetate-HCl, IPA-HC1, ethanol-HCl, methanol-HCl; in step-e) the suitable base is selected from organic base or inorganic base; in step-a) to step-e) the suitable solvent is selected from hydrocarbon solvents, ketone solvents, ester solvents, chloro solvents, nitrile solvents, alcohol solvents, ether solvents, polar aprotic solvents and polar solvents like water and mixture thereof.
6. The process as claimed in claim-4 & 5, wherein, a process for the preparation of 5-chloro-N4-[2-[(l-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(l-methyl ethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine compound of formula-1, comprising of:

a) Reduction of l-chloro-5-isopropoxy-2-methyl-4-nitrobenzene compound of formula-2 with FeMHjCl in a mixture of methanol and water to provide 4-chloro-2-isopropoxy-5-methylaniline compound of formula-3,
b) reacting the compound of formula-3 with 2,5-dichloro-N-(2-(isopropylsulfonyl)

phenyl)pyrimidin-4-amine compound of formula-4 in presence of isopropanolic hydrochloride in isopropanol to provide 5-chloro-N2-(4-chloro-2-isopropoxy-5-methyl phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine compound of formula-5,
c) reacting the compound of formula-5 with tert butyl 4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)piperidine-l-carboxylate compound of formula-6b in presence of tetrakis(triphenylphosphine)palladium(0) and sodium carbonate in a mixture of water and 1,4-dioxane to provide tert-butyl 4-(4-(5-chloro-4-(2-(isopropylsulfonyl)phenyl amino)pyrimidin-2-ylamino)-5-isopropoxy-2-methylphenyl)piperidine-l-carboxylate compound of formula-7b,
d) reacting the compound of formula-7b with isopropanolic hydrochloric acid and isopropanol to provide 5-chloro-N4-[2-[(l-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(l -methyl ethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine dihydrochloride salt compound of formula-Id followed by purifying the compound of formula-Id using a mixture of isopropanol and water and then followed by dimethyl formamide to provide pure compound of formula-Id,
e) treating the compound of formula-Id with aqueous sodium hydroxide in a mixture of water, acetone and dichloromethane to provide compound of formula-1,
f) dissolving the compound of formula-1 in dichloromethane and adding the reaction mixture to a pre-cooled n-heptane and followed by purifying the obtained compound using n-heptane to provide pure crystalline 5-chloro-N4-[2-[(l-methylethyl)sulfonyl] phenyl]-N2-[5-methyl-2-(l -methyl ethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidine diamine compound of formula-1.
7. Crystalline form of compounds, which includes:
a) Crystalline form-Mi of 4-(5-isopropoxy-2-methyl-4-nitrophenyl)pyridine compound of formula-25, characterized by its powder x-ray diffraction pattern having peaks 9.6, 10.4, 13.1, 13.3, 14.5, 15.1, 15.3, 17.4, 18.0, 18.6, 21.0, 21.2, 21.8, 22.5, 23.2, 23.7, 24.2, 25.9, 26.6, 28.8 and 30.5 ±0.2 degrees two theta and its P-XRD pattern as depicted in figure-1.
b) Crystalline form-M2 of 2-isopropoxy-5-methyl-4-(piperidin-4-yl)aniline

dihydrochloride salt monohydrate compound of formula-21a, characterized by its powder x-ray diffraction pattern having peaks 10.5, 12.7, 13.5, 16.0, 17.3, 18.5, 18.4,
19.6, 19.9, 20.3, 20.4, 21.0, 21.4, 22.0, 22.7, 23.4, 23.7, 24.6, 25.4, 25.9, 26.3, 27.1,
27.6, 27.9, 28.3, 29.5, 31.0, 31.5, 32.3, 32.8, 33.6, 34.4, 35.0, 35.4, 36.2, 39.3, 40.3, 41.0, 41.4 and 43.5 ±0.2 degrees two theta and its P-XRD pattern as depicted in figure-2.
c) Crystalline form-M3 of N-(4-(l-acetylpiperidin-4-yl)-2-isopropoxy-5-methylphenyl)
acetamide hydrochloride salt compound of formula-19a, characterized by its powder
x-ray diffraction pattern having peaks 9.1, 10.2, 10.4, 10.6, 12.2, 12.5, 13.1, 13.3,
13.8, 14.7, 15.8, 16.3, 17.1, 18.3, 18.8, 19.9, 20.2, 20.7, 21.4, 21.9, 22.1, 22.9, 24.1,
25.0, 25.2, 25.6, 26.0, 26.5, 26.7, 27.6, 28.1, 28.6, 30.3, 31.5, 31.9, 32.8 and 34.6 ±0.2
degrees two theta and its P-XRD pattern as depicted in figure-3.
d) Crystalline form-M4 of tert-butyl 4-(4-(tert-butoxycarbonylamino)-5-isopropoxy-2-
methylphenyl)piperidine-l-carboxylate compound of formula-19b, characterized by its
powder x-ray diffraction pattern having peaks 7.3, 10.3, 10.7, 12.9, 14.4, 16.5, 17.4,
18.9, 18.4, 20.0, 20.4, 21.0, 21.5, 21.9, 23.4, 23.6, 25.0, 28.0, 28.2, 28.9, 30.1 and 30.6
±0.2 degrees two theta and its P-XRD pattern as depicted in figure-5.
e) Crystalline form-N5 of 5-chloro-N4-[2-[(l-methylethyl)sulfonyl]phenyl]-N2-[5-
methyl-2-(l -methyl ethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine
dihydrochloric acid salt compound of formula-Id is characterized by its P-XRD
pattern as depicted in figure-4.
8. Compounds having the structural formulae or its salts:
9. A process for the preparation of amorphous form of 5-chloro-N4-[2-[(l-methylethyl) sulfonyl]phenyl]-N2-[5-methyl-2-(l-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine compound of formula-1, comprising of:

a) Adding a suitable base and a suitable solvent to 5-chloro-N4-[2-[(l-methylethyl)
sulfonyl]phenyl]-N2-[5-methyl-2-(l-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-
pyrimidinediamine dihydrochloride compound of formula-Id,
b) stirring the reaction mixture,
c) distilling off the solvent completely from the reaction mixture to get the amorphous form of 5-chloro-N4-[2-[(l-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(l-methyl ethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine compound of formula-1.
Wherein, in step-a) the suitable base is selected from organic or inorganic base and a suitable solvent is selected from hydrocarbon solvents, ketone solvents, ester solvents, chloro solvents, nitrile solvents, alcohol solvents, ether solvents, polar aprotic solvents and polar solvents like water and mixture thereof.
10. Acid addition salts of N,N'-protected 2-isopropoxy-5-methyl-4-(piperidin-4-yl)aniline compound of general formula-19.
Wherein, Pg is an amino protecting group
Wherein the "Acid" is selected from inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid or phosphoric acid; and organic acids such as oxalic acid, maleic acid, malonic acid, tartaric acid, fumaric acid, citric acid, malic acid, succinic acid, mandelic acid, lactic acid, acetic acid, propionic acid, 2-chloromandelate, p-toluene sulfonic acid, ethane-1,2-disulfonic acid, camphor sulfonic acid, ethane sulfonic acid, methane sulfonic acid, benzene sulfonic acid, adipic acid and palmitic acid.