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Novel Process Of Cross Reacting Material 197 (Crm197) Purification
Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using media supplemented with a mixture of glycerol, nitrogen salts & trace elements whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; ( 2) adding a stabilizer mixture of atleast one Sugar,atleast one detergent & atleast one protease inhibitor during purification; and (3) operating two chromatographic separation steps wherein ion exchange chromatography is followed by hydrophobic interaction chromatography hydrophobic matrix, and eluting a fraction containing the toxin having purity of more than 99%.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
22 April 2009
Publication Number
45/2010
Publication Type
INA
Invention Field
BIOTECHNOLOGY
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2016-12-09
Renewal Date
Applicants
Serum Institute of India Ltd.
212/2 Off Soli Poonawalla Road Hadapsar Pune 411 028 Maharashtra India.
Inventors
1. KAPRE Subhash V.
c/o Serum Institute of India Ltd. of 212/2 Off Soli Poonawalla Road Hadapsar Pune 411 028 Maharashtra India.
2. SHALIGRAM Umesh
c/o Serum Institute of India Ltd. of 212/2 Off Soli Poonawalla Road Hadapsar Pune 411 028 Maharashtra India.
Specification
attached
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 1075-MUM-2009-FORM 18(14-11-2011).pdf | 2011-11-14 |
| 1 | 1075-MUM-2009-FORM-27 [27-09-2024(online)].pdf | 2024-09-27 |
| 2 | 1075-MUM-2009-CORRESPONDENCE(14-11-2011).pdf | 2011-11-14 |
| 2 | 1075-MUM-2009-RELEVANT DOCUMENTS [27-09-2023(online)].pdf | 2023-09-27 |
| 3 | 1075-MUM-2009-RELEVANT DOCUMENTS [30-09-2022(online)].pdf | 2022-09-30 |
| 3 | 1075-MUM-2009-CORRESPONDENCE(IPO)-(FER)-(08-05-2015).pdf | 2015-05-08 |
| 4 | 1075-MUM-2009-RELEVANT DOCUMENTS [28-09-2021(online)].pdf | 2021-09-28 |
| 4 | 1075-MUM-2009-FORM 13-(04-01-2016).pdf | 2016-01-04 |
| 5 | Other Document [05-01-2016(online)].pdf | 2016-01-05 |
| 5 | 1075-MUM-2009-RELEVANT DOCUMENTS [19-03-2020(online)].pdf | 2020-03-19 |
| 6 | Form 13 [05-01-2016(online)].pdf | 2016-01-05 |
| 6 | 1075-MUM-2009-RELEVANT DOCUMENTS [26-02-2019(online)].pdf | 2019-02-26 |
| 7 | OTHERS [06-05-2016(online)].pdf | 2016-05-06 |
| 7 | 1075-MUM-2009-ABSTRACT(22-4-2010).pdf | 2018-08-10 |
| 8 | Examination Report Reply Recieved [06-05-2016(online)].pdf | 2016-05-06 |
| 8 | 1075-MUM-2009-CLAIMS(22-4-2010).pdf | 2018-08-10 |
| 9 | 1075-MUM-2009-CORRESPONDENCE(17-6-2009).pdf | 2018-08-10 |
| 9 | Description(Complete) [06-05-2016(online)].pdf | 2016-05-06 |
| 10 | 1075-MUM-2009-CORRESPONDENCE(22-4-2010).pdf | 2018-08-10 |
| 10 | Claims [06-05-2016(online)].pdf | 2016-05-06 |
| 11 | 1075-MUM-2009-Correspondence-180416.pdf | 2018-08-10 |
| 11 | Abstract [06-05-2016(online)].pdf | 2016-05-06 |
| 12 | 1075-MUM-2009-CORRESPONDENCE(IPO)-(HEARING NOTICE)-(29-09-2016).pdf | 2016-09-29 |
| 12 | 1075-MUM-2009-DESCRIPTION(COMPLETE)-(22-4-2010).pdf | 2018-08-10 |
| 13 | 1075-MUM-2009-DRAWING(22-4-2010).pdf | 2018-08-10 |
| 13 | HEARING ADJOURNMENT [18-10-2016(online)].pdf | 2016-10-18 |
| 14 | 1075-MUM-2009-FORM 1(17-6-2009).pdf | 2018-08-10 |
| 14 | Other Patent Document [03-11-2016(online)].pdf | 2016-11-03 |
| 15 | 1075-MUM-2009-Form 1-180416.pdf | 2018-08-10 |
| 15 | HEARING ADJOURNMENT [09-11-2016(online)].pdf | 2016-11-09 |
| 16 | 1075-MUM-2009-CORRESPONDENCE(IPO)-(HEARING NOTICE)-(11-11-2016).pdf | 2016-11-11 |
| 16 | 1075-mum-2009-form 2(22-4-2010).pdf | 2018-08-10 |
| 17 | Other Patent Document [21-11-2016(online)].pdf | 2016-11-21 |
| 17 | 1075-MUM-2009-FORM 2(TITLE PAGE)-(22-4-2010).pdf | 2018-08-10 |
| 18 | 1075-MUM-2009-Form 2(Title Page)-180416.pdf | 2018-08-10 |
| 18 | Other Patent Document [05-12-2016(online)].pdf | 2016-12-05 |
| 19 | 1075-MUM-2009-FORM 2-(GRANTED)-(09-12-2016).pdf | 2016-12-09 |
| 19 | 1075-MUM-2009-FORM 5(22-4-2010).pdf | 2018-08-10 |
| 20 | 1075-MUM-2009-FORM 2(TITLE PAGE)-(GRANTED)-(09-12-2016).pdf | 2016-12-09 |
| 20 | 1075-MUM-2009-OTHERS-180416.pdf | 2018-08-10 |
| 21 | 1075-MUM-2009-DRAWING(GRANTED)-(09-12-2016).pdf | 2016-12-09 |
| 21 | 1075-MUM-2009-Power of Attorney-180416.pdf | 2018-08-10 |
| 22 | 1075-MUM-2009-DESCRIPTION(GRANTED)-(09-12-2016).pdf | 2016-12-09 |
| 22 | 1075-MUM-2009-POWER OF AUTHORITY(17-6-2009).pdf | 2018-08-10 |
| 23 | 1075-MUM-2009-CORRESPONDENCE(IPO)-(ORDER)-(09-12-2016).pdf | 2016-12-09 |
| 23 | 1075-MUM-2009_EXAMREPORT.pdf | 2018-08-10 |
| 24 | Form-1.pdf | 2018-08-10 |
| 24 | 1075-MUM-2009-CORRESPONDENCE(IPO)-(09-12-2016).pdf | 2016-12-09 |
| 25 | 1075-MUM-2009-CLAIMS(GRANTED)-(09-12-2016).pdf | 2016-12-09 |
| 25 | Form-3.pdf | 2018-08-10 |
| 26 | 1075-MUM-2009-ABSTRACT(GRANTED)-(09-12-2016).pdf | 2016-12-09 |
| 26 | 1075-MUM-2009-RELEVANT DOCUMENTS [07-03-2018(online)].pdf | 2018-03-07 |
| 27 | Form 27 [07-02-2017(online)].pdf | 2017-02-07 |
| 28 | 1075-MUM-2009-ABSTRACT(GRANTED)-(09-12-2016).pdf | 2016-12-09 |
| 28 | 1075-MUM-2009-RELEVANT DOCUMENTS [07-03-2018(online)].pdf | 2018-03-07 |
| 29 | 1075-MUM-2009-CLAIMS(GRANTED)-(09-12-2016).pdf | 2016-12-09 |
| 29 | Form-3.pdf | 2018-08-10 |
| 30 | 1075-MUM-2009-CORRESPONDENCE(IPO)-(09-12-2016).pdf | 2016-12-09 |
| 30 | Form-1.pdf | 2018-08-10 |
| 31 | 1075-MUM-2009-CORRESPONDENCE(IPO)-(ORDER)-(09-12-2016).pdf | 2016-12-09 |
| 31 | 1075-MUM-2009_EXAMREPORT.pdf | 2018-08-10 |
| 32 | 1075-MUM-2009-DESCRIPTION(GRANTED)-(09-12-2016).pdf | 2016-12-09 |
| 32 | 1075-MUM-2009-POWER OF AUTHORITY(17-6-2009).pdf | 2018-08-10 |
| 33 | 1075-MUM-2009-DRAWING(GRANTED)-(09-12-2016).pdf | 2016-12-09 |
| 33 | 1075-MUM-2009-Power of Attorney-180416.pdf | 2018-08-10 |
| 34 | 1075-MUM-2009-FORM 2(TITLE PAGE)-(GRANTED)-(09-12-2016).pdf | 2016-12-09 |
| 34 | 1075-MUM-2009-OTHERS-180416.pdf | 2018-08-10 |
| 35 | 1075-MUM-2009-FORM 2-(GRANTED)-(09-12-2016).pdf | 2016-12-09 |
| 35 | 1075-MUM-2009-FORM 5(22-4-2010).pdf | 2018-08-10 |
| 36 | Other Patent Document [05-12-2016(online)].pdf | 2016-12-05 |
| 36 | 1075-MUM-2009-Form 2(Title Page)-180416.pdf | 2018-08-10 |
| 37 | Other Patent Document [21-11-2016(online)].pdf | 2016-11-21 |
| 37 | 1075-MUM-2009-FORM 2(TITLE PAGE)-(22-4-2010).pdf | 2018-08-10 |
| 38 | 1075-MUM-2009-CORRESPONDENCE(IPO)-(HEARING NOTICE)-(11-11-2016).pdf | 2016-11-11 |
| 38 | 1075-mum-2009-form 2(22-4-2010).pdf | 2018-08-10 |
| 39 | 1075-MUM-2009-Form 1-180416.pdf | 2018-08-10 |
| 39 | HEARING ADJOURNMENT [09-11-2016(online)].pdf | 2016-11-09 |
| 40 | 1075-MUM-2009-FORM 1(17-6-2009).pdf | 2018-08-10 |
| 40 | Other Patent Document [03-11-2016(online)].pdf | 2016-11-03 |
| 41 | 1075-MUM-2009-DRAWING(22-4-2010).pdf | 2018-08-10 |
| 41 | HEARING ADJOURNMENT [18-10-2016(online)].pdf | 2016-10-18 |
| 42 | 1075-MUM-2009-CORRESPONDENCE(IPO)-(HEARING NOTICE)-(29-09-2016).pdf | 2016-09-29 |
| 42 | 1075-MUM-2009-DESCRIPTION(COMPLETE)-(22-4-2010).pdf | 2018-08-10 |
| 43 | 1075-MUM-2009-Correspondence-180416.pdf | 2018-08-10 |
| 43 | Abstract [06-05-2016(online)].pdf | 2016-05-06 |
| 44 | 1075-MUM-2009-CORRESPONDENCE(22-4-2010).pdf | 2018-08-10 |
| 44 | Claims [06-05-2016(online)].pdf | 2016-05-06 |
| 45 | 1075-MUM-2009-CORRESPONDENCE(17-6-2009).pdf | 2018-08-10 |
| 45 | Description(Complete) [06-05-2016(online)].pdf | 2016-05-06 |
| 46 | Examination Report Reply Recieved [06-05-2016(online)].pdf | 2016-05-06 |
| 46 | 1075-MUM-2009-CLAIMS(22-4-2010).pdf | 2018-08-10 |
| 47 | OTHERS [06-05-2016(online)].pdf | 2016-05-06 |
| 47 | 1075-MUM-2009-ABSTRACT(22-4-2010).pdf | 2018-08-10 |
| 48 | Form 13 [05-01-2016(online)].pdf | 2016-01-05 |
| 48 | 1075-MUM-2009-RELEVANT DOCUMENTS [26-02-2019(online)].pdf | 2019-02-26 |
| 49 | Other Document [05-01-2016(online)].pdf | 2016-01-05 |
| 49 | 1075-MUM-2009-RELEVANT DOCUMENTS [19-03-2020(online)].pdf | 2020-03-19 |
| 50 | 1075-MUM-2009-RELEVANT DOCUMENTS [28-09-2021(online)].pdf | 2021-09-28 |
| 50 | 1075-MUM-2009-FORM 13-(04-01-2016).pdf | 2016-01-04 |
| 51 | 1075-MUM-2009-CORRESPONDENCE(IPO)-(FER)-(08-05-2015).pdf | 2015-05-08 |
| 51 | 1075-MUM-2009-RELEVANT DOCUMENTS [30-09-2022(online)].pdf | 2022-09-30 |
| 52 | 1075-MUM-2009-CORRESPONDENCE(14-11-2011).pdf | 2011-11-14 |
| 52 | 1075-MUM-2009-RELEVANT DOCUMENTS [27-09-2023(online)].pdf | 2023-09-27 |
| 53 | 1075-MUM-2009-FORM 18(14-11-2011).pdf | 2011-11-14 |
| 53 | 1075-MUM-2009-FORM-27 [27-09-2024(online)].pdf | 2024-09-27 |