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Novel Resorcinol Derivatives

Abstract: New 4-substituted resorcinol derivatives of general formula (I) and/or B and process for synthesizing same, cosmetic compositions and methods of using same, particularly for skin lightening and/or reducing the appearance of oily or greasy skin: wherein, X1 and/or X2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl, alkenyl, or acyl groups; preferably X1 and/or X2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl or acyl groups; R1 and/or R2 represents hydrogen (H), linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12 alkyl, alkenyl, cycloalkyl, or cycloalkenyl group; n represents 0, 1; and when n = 0, the ring is a cyclopentyl with or without one heteroatom from O, N or S and/or with or without one double bond; and when n = 1, the ring is a cyclohexyl with or without one heteroatom from O, N or S and/or with or without one double bond; and m represents an integer between 1 and 6.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
13 September 2007
Publication Number
44/2007
Publication Type
INA
Invention Field
PHARMACEUTICALS
Status
Email
Parent Application

Applicants

HINDUSTAN UNILEVER LIMITED
HINDUSTAN LEVER HOUSE, 165/166 BACKBAY RECLAMATION, MUMBAI.

Inventors

1. HARICHIAN BIJAN
UNILEVER HOME & PERSONAL CARE USA, 40 MERRITT BOULEVARD TRUMBULL, CONNECTICUT 06611.
2. JOSE GUILLERMO ROSA
UNILEVER HOME & PERSONAL CARE USA, 40 MERRITT BOULEVARD TRUMBULL, CONNECTICUT 06611.
3. JOHN STEVEN BAJOR
UNILEVER HOME & PERSONAL CARE USA, 40 MERRITT BOULEVARD TRUMBULL, CONNECTICUT 06611.

Specification

J6954/C FORM - 2 THE PATENTS ACT, 1970 (39 of 1970) & The Patents Rules, 2003 COMPLETE SPECIFICATION (See Section 10 and Rule 13) NOVEL RESORCINOL DERIVATIVES HINDUSTAN UNILEVER LIMITED, a company incorporated under the Indian Companies Act, 1913 and having its registered office at Hindustan Lever House, 165/166, Backbay Reclamation, Mumbai -400 020, Maharashtra, India The following specification particularly describes the invention and the manner in which it is to be performed WO 2006/097223 PCT/EP2006/002072 NOVEL RESORCINOL DERIVATIVES FIELD OF THE INVENTION The invention relates to new 4-substituted resorcinol derivatives, cosmetic compositions containing same, and cosmetic methods of using and making same. More specifically, the present invention relates to new 4-substituted resorcinol derivatives as skin cosmetic actives, cosmetic compositions and methods of using same for skin lightening, reducing the appearance of oily or greasy skin and/or other cosmetic skin benefits. BACKGROUND OF THE INVENTION Many people are concerned with the degree of pigmentation of their skin. For example, people with age spots or freckles may wish such pigmented spots to be less pronounced. Others may wish to reduce the skin darkening caused by exposure to sunlight or to lighten their natural skin color. To meet this need, many attempts have been made to develop products that reduce the pigment production in the melanocytes. However, the substances identified thus far tend to have either low efficacy or undesirable side effects, such as, for example, toxicity or skin irritation. Therefore, there is a continuing need for new skin lightening agents, with improved overall effectiveness. Sebum is skin oil which is produced by sebocytes (cells of the sebaceous glands in the skin) and is then secreted to the skin surface. Sebum is made up of a number of components, with about 57 % being triglycerides, or fatty acids. About 12 % of sebum is squalene, about 3 % of sebum are sterol esters, about 25 % wax esters, and about 1 to about 2 % cholesterol. A frequent and undesirable skin condition is ‘oily skin," the condition which results from the excessive amount of sebum on" the skin. Oily skin is associated with a shiny, undesirable WO 2006/097223 PCT/EP2006/002072 appearance and a disagreeable tactile sensation and affects various age groups. Excessive sebum production is cosmetically undesirable and has been associated with the skin condition acne. Therefore, cosmetic products and methods that provide sebum control or reduce the appearance of oily or greasy skin are highly desirable. Resorcinol derivatives are generally known compounds and can be readily obtained, for example, by a method wherein a saturated carboxylic acid and resorcinol are condensed in the presence of zinc chloride and the resultant condensate is reduced with zinc amalgam/hydrochloric acid (Lille. J. Bitter, LA. Peiner. V, Tr. Nauch-Issled. Inst, slantsev 1969, No. IB, 127), or by a method wherein resorcinol and a corresponding alkyl alcohol are reacted in the presence of an alumina catalyst at a high temperature of from 200 to 400° C

Documents

Application Documents

# Name Date
1 1418-MUMNP-2007- PUBLICATION REPORT.pdf 2022-02-02
1 1418-MUMNP-2007-PCT-OTHER(15-07-2008).pdf 2008-07-15
2 1418-MUMNP-2007-ASSIGNMENT(13-9-2007).pdf 2018-08-09
2 1418-MUMNP-2007-PCT-IPEA-416(15-07-2008).pdf 2008-07-15
3 1418-MUMNP-2007-PCT-IPEA-409(15-07-2008).pdf 2008-07-15
3 1418-mumnp-2007-assignment.pdf 2018-08-09
4 1418-MUMNP-2007-CORRESPONDENCE(15-07-2008).pdf 2008-07-15
4 1418-mumnp-2007-cancelled pages(25-9-2009).pdf 2018-08-09
5 1418-MUMNP-2007-CORRESPONDENCE(24-11-2009).pdf 2009-11-24
5 1418-mumnp-2007-claims(13-9-2007).pdf 2018-08-09
6 abstract1.jpg 2018-08-09
6 1418-MUMNP-2007-CLAIMS(24-2-2009).pdf 2018-08-09
7 1418-MUMNP-2007_EXAMREPORT.pdf 2018-08-09
7 1418-MUMNP-2007-CLAIMS(25-9-2009).pdf 2018-08-09
8 1418-MUMNP-2007-CLAIMS(29-6-2009).pdf 2018-08-09
8 1418-mumnp-2007-wo international publication report (13-9-2007).pdf 2018-08-09
9 1418-mumnp-2007-pct-search report.pdf 2018-08-09
10 1418-mumnp-2007-claims.pdf 2018-08-09
10 1418-MUMNP-2007-GENERAL POWER OF ATTORNEY(24-2-2009).pdf 2018-08-09
11 1418-mumnp-2007-correspondence 1(16-1-2008).pdf 2018-08-09
11 1418-mumnp-2007-form-pct-separate sheet-409.pdf 2018-08-09
12 1418-mumnp-2007-correspondence 2(23-9-2009).pdf 2018-08-09
12 1418-mumnp-2007-form-ipea-409.pdf 2018-08-09
13 1418-MUMNP-2007-CORRESPONDENCE 2-7-2008.pdf 2018-08-09
13 1418-mumnp-2007-form-5.pdf 2018-08-09
14 1418-MUMNP-2007-CORRESPONDENCE(23-9-2009).pdf 2018-08-09
14 1418-mumnp-2007-form-3.pdf 2018-08-09
15 1418-MUMNP-2007-CORRESPONDENCE(24-2-2009).pdf 2018-08-09
15 1418-mumnp-2007-form-2.pdf 2018-08-09
16 1418-MUMNP-2007-CORRESPONDENCE(29-6-2009).pdf 2018-08-09
17 1418-mumnp-2007-form-1.pdf 2018-08-09
17 1418-mumnp-2007-correspondence(ipo)-(16-9-2010).pdf 2018-08-09
18 1418-mumnp-2007-correspondence-others.pdf 2018-08-09
18 1418-MUMNP-2007-FORM 5(24-2-2009).pdf 2018-08-09
19 1418-mumnp-2007-description (complete).pdf 2018-08-09
19 1418-MUMNP-2007-FORM 5(13-9-2007).pdf 2018-08-09
20 1418-mumnp-2007-description(complete)-(13-9-2007).pdf 2018-08-09
20 1418-MUMNP-2007-FORM 2(TITLE PAGE)-(29-6-2009).pdf 2018-08-09
21 1418-MUMNP-2007-DESCRIPTION(COMPLETE)-(24-2-2009).pdf 2018-08-09
21 1418-MUMNP-2007-FORM 2(TITLE PAGE)-(24-2-2009).pdf 2018-08-09
22 1418-MUMNP-2007-DESCRIPTION(COMPLETE)-(29-6-2009).pdf 2018-08-09
22 1418-mumnp-2007-form 2(title page)-(13-9-2007).pdf 2018-08-09
23 1418-MUMNP-2007-FORM 1(13-9-2007).pdf 2018-08-09
23 1418-mumnp-2007-form 2(29-6-2009).pdf 2018-08-09
24 1418-mumnp-2007-form 2(24-2-2009).pdf 2018-08-09
24 1418-MUMNP-2007-FORM 1(29-6-2009).pdf 2018-08-09
25 1418-mumnp-2007-form 18(16-1-2008).pdf 2018-08-09
25 1418-mumnp-2007-form 2(13-9-2007).pdf 2018-08-09
26 1418-mumnp-2007-form 18(16-1-2008).pdf 2018-08-09
26 1418-mumnp-2007-form 2(13-9-2007).pdf 2018-08-09
27 1418-MUMNP-2007-FORM 1(29-6-2009).pdf 2018-08-09
27 1418-mumnp-2007-form 2(24-2-2009).pdf 2018-08-09
28 1418-MUMNP-2007-FORM 1(13-9-2007).pdf 2018-08-09
28 1418-mumnp-2007-form 2(29-6-2009).pdf 2018-08-09
29 1418-MUMNP-2007-DESCRIPTION(COMPLETE)-(29-6-2009).pdf 2018-08-09
29 1418-mumnp-2007-form 2(title page)-(13-9-2007).pdf 2018-08-09
30 1418-MUMNP-2007-DESCRIPTION(COMPLETE)-(24-2-2009).pdf 2018-08-09
30 1418-MUMNP-2007-FORM 2(TITLE PAGE)-(24-2-2009).pdf 2018-08-09
31 1418-mumnp-2007-description(complete)-(13-9-2007).pdf 2018-08-09
31 1418-MUMNP-2007-FORM 2(TITLE PAGE)-(29-6-2009).pdf 2018-08-09
32 1418-mumnp-2007-description (complete).pdf 2018-08-09
32 1418-MUMNP-2007-FORM 5(13-9-2007).pdf 2018-08-09
33 1418-mumnp-2007-correspondence-others.pdf 2018-08-09
33 1418-MUMNP-2007-FORM 5(24-2-2009).pdf 2018-08-09
34 1418-mumnp-2007-form-1.pdf 2018-08-09
34 1418-mumnp-2007-correspondence(ipo)-(16-9-2010).pdf 2018-08-09
35 1418-MUMNP-2007-CORRESPONDENCE(29-6-2009).pdf 2018-08-09
36 1418-MUMNP-2007-CORRESPONDENCE(24-2-2009).pdf 2018-08-09
36 1418-mumnp-2007-form-2.pdf 2018-08-09
37 1418-MUMNP-2007-CORRESPONDENCE(23-9-2009).pdf 2018-08-09
37 1418-mumnp-2007-form-3.pdf 2018-08-09
38 1418-MUMNP-2007-CORRESPONDENCE 2-7-2008.pdf 2018-08-09
38 1418-mumnp-2007-form-5.pdf 2018-08-09
39 1418-mumnp-2007-correspondence 2(23-9-2009).pdf 2018-08-09
39 1418-mumnp-2007-form-ipea-409.pdf 2018-08-09
40 1418-mumnp-2007-correspondence 1(16-1-2008).pdf 2018-08-09
40 1418-mumnp-2007-form-pct-separate sheet-409.pdf 2018-08-09
41 1418-mumnp-2007-claims.pdf 2018-08-09
41 1418-MUMNP-2007-GENERAL POWER OF ATTORNEY(24-2-2009).pdf 2018-08-09
42 1418-mumnp-2007-pct-search report.pdf 2018-08-09
43 1418-MUMNP-2007-CLAIMS(29-6-2009).pdf 2018-08-09
43 1418-mumnp-2007-wo international publication report (13-9-2007).pdf 2018-08-09
44 1418-MUMNP-2007-CLAIMS(25-9-2009).pdf 2018-08-09
44 1418-MUMNP-2007_EXAMREPORT.pdf 2018-08-09
45 1418-MUMNP-2007-CLAIMS(24-2-2009).pdf 2018-08-09
45 abstract1.jpg 2018-08-09
46 1418-MUMNP-2007-CORRESPONDENCE(24-11-2009).pdf 2009-11-24
46 1418-mumnp-2007-claims(13-9-2007).pdf 2018-08-09
47 1418-MUMNP-2007-CORRESPONDENCE(15-07-2008).pdf 2008-07-15
47 1418-mumnp-2007-cancelled pages(25-9-2009).pdf 2018-08-09
48 1418-MUMNP-2007-PCT-IPEA-409(15-07-2008).pdf 2008-07-15
48 1418-mumnp-2007-assignment.pdf 2018-08-09
49 1418-MUMNP-2007-PCT-IPEA-416(15-07-2008).pdf 2008-07-15
49 1418-MUMNP-2007-ASSIGNMENT(13-9-2007).pdf 2018-08-09
50 1418-MUMNP-2007- PUBLICATION REPORT.pdf 2022-02-02
50 1418-MUMNP-2007-PCT-OTHER(15-07-2008).pdf 2008-07-15