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Nutraceutical And Antioxidant Formulation And The Process Of Preparation Thereof

Abstract: ABSTRACT NUTRACEUTICAL AND ANTIOXIDANT FORMULATION AND THE PROCESS OF PREPARATION THEREOF A nutraceutical composition consists of a dried powder of ingredients Fructooligosaccharides, Extracts of Gooseberry, Acai Berry, Xanthone, Cranberry, Strawberry, Gojiberry, Cherry, Raspberry, Bilberry, Black Currant, Blueberry, Redberry, Elderberry, Huckle Berry, Mulberry, Stone Berry, Sea Buckthorn and Grape comprising a combination of the pulp, pericarp, bark and roots of the ingredients with essential minerals such as Magnesium Carbonate, Magnesium Sulphate, Tri-Sodium Citrate, Potassium Chloride, Sodium Chloride, Acidity Regulator (E330), Sucralose (E955) and added flavour of natural flavouring substances, berries and lemon to make taste.with flavoring agents to prepare different drug delivery system. The nutraceutical composition is prepared by a process comprising the steps of grinding or powdering the dried ingredient(s); extracting the crushed or powdered herb with aqueous alcohol in the range of 5 to 95% v/v water to alcohol for 5 to 48 hours at a temperature of 20 to 50° C.; filtering and distilling said alcohol under reduced pressure at 20 to 80° C in order to obtain extract the ingredient; mixing extracts of all the ingredients in definite proportion with flavoring agents to obtain the product.

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Patent Information

Application #
Filing Date
29 March 2023
Publication Number
40/2024
Publication Type
INA
Invention Field
BIOTECHNOLOGY
Status
Email
Parent Application

Applicants

RENATUS WELLNESS PRIVATE LIMITED
212, Biswa Bangla Sarani, PS IXL Building, Atgarha, Kolkata , West Bengal, India

Inventors

1. DUTTA, Rajdeep
212, Biswa Bangla Sarani, PS IXL Building, Atgarha, Kolkata – 700136,

Specification

Description:FIELD OF THE INVENTION
The present invention relates to nutraceutical formulations derived from the ingredients including Fructooligosaccharides, Extracts of Gooseberry, Acai Berry, Xanthone, Cranberry, Strawberry, Gojiberry, Cherry, Raspberry, Bilberry, Black Currant, Blueberry, Redberry, Elderberry, Huckle Berry, Mulberry, Stone Berry, Sea Buckthorn and Grape. More particularly, the present invention relates to nutraceutical formulations comprising a combination of the pulp, pericarp, bark and roots of the ingredients with essential minerals such as Magnesium Carbonate, Magnesium Sulphate, Tri-Sodium Citrate, Potassium Chloride, Sodium Chloride, Acidity Regulator (E330), Sucralose (E955) and added flavour of natural flavouring substances, berries and lemon to make taste.
BACKGROUND ART
The nutraceutical food or parts of food may provide medical health benefits including the prevention and or treatment of diseases. Nutraceuticals, are foods or bioactive ingredients in foods that protect or promote health whether delivered in raw agricultural commodities, processed foods, dietary supplements, extracts, beverages or other products and occurs at the intersection of food and pharmaceutical industries. The development of next generation nutraceutical “super foods” or products consist of value-addition in the traditional natural diets. Their ingredients have tremendous impact on the health care system and may provide medical health benefits including the prevention and or treatment of diseases. Nutraceuticals have potential to be used as food supplement, preventive medicine and the growing evidence points in the direction that certain foods fight and or prevent against diseases.
The word Nutraceuticals combine ‘nutrition’ and ‘pharmaceuticals’ to mean that they can be used as preventive drugs or food supplements. The entire concept is based on the disease preventing/treating phytonutrients present in foodstuffs of the diet in combating diseases e.g. phytosterols compete with dietary cholesterol for uptake in intestine thereby blocking cholesterol absorption into the body and can also prevent the development of tumor in breast and prostate glands. Phenols a large group of phytonutrients, have profound importance in preventive medicine. Phytochemicals can enhance the efficacy of vitamin C, can also act against allergies, ulcers, tumors, platelet aggregation, controlling hypertension and reduce the risk of estrogen induced cancer.
SUMMARY OF THE INVENTION
An extract combination is formulated to improve a person's wellbeing, with possible implications to enhance immunity and further lowering the risks of several diseases and/or lowering blood sugar using natural ingredients. A mixture formulation of the present invention may be used as a food or a drink or a supplement. Numerous ratios may be formulated for aroma, color, flavor, flow (viscosity), taste and uniformity. The mixture may be diluted with water, beverages and/or milk.
Therefore such as herein described there is provided a nutraceutical mixture formulation, the formulation consisting essentially of a dried mixture of ingredients including Fructooligosaccharides, Extracts of Gooseberry, Acai Berry, Xanthone, Cranberry, Strawberry, Gojiberry, Cherry, Raspberry, Bilberry, Black Currant, Blueberry, Redberry, Elderberry, Huckle Berry, Mulberry, Stone Berry, Sea Buckthorn and Grape in a definite proportion with added flavoring agents in a concentrated / diluted syrup, tablet or capsule as a drug delivery system. Some extracts in nano form are used to increase the cell assimilation rate i.e. to increase the drug delivery system quickly and without any side effects.
Being the nano form of nutraceutical, the essentials elements can directly assimilate on cellular structure without any hazards and also not increasing blood density level. Due to nano form, it can travel anywhere even in the case of Thrombosis it will pass through clot due to its nano form and not hampering the blood density level and also, targets to lowering insulin resistance level to correct auto immune disorder.
The blend of the ingredients provides more nutritional benefits due to high fibre and high antioxidant content. The deliciously blend of berries provides nutritional benefits that fight against free radicals from the body cells and reduce the damage caused by oxidation.
In a preferred embodiment, there is provided a nutraceutical composition consists of a dried powder of ingredients Fructooligosaccharides, Extracts of Gooseberry, Acai Berry, Xanthone, Cranberry, Strawberry, Gojiberry, Cherry, Raspberry, Bilberry, Black Currant, Blueberry, Redberry, Elderberry, Huckle Berry, Mulberry, Stone Berry, Sea Buckthorn and Grape with flavoring agents to prepare different drug delivery system.
The present invention also provides a method of preparing a formulation by way of drying a product of ingredients including Fructooligosaccharides, Extracts of Gooseberry, Acai Berry, Xanthone, Cranberry, Strawberry, Gojiberry, Cherry, Raspberry, Bilberry, Black Currant, Blueberry, Redberry, Elderberry, Huckle Berry, Mulberry, Stone Berry, Sea Buckthorn and Grape comprising heating the proportionate weight in the mixer of the ingredients.
The present invention also provides a dried product produced by the method of claim 1. In some embodiments, the ratio of the components in the product to be dried is retained throughout the dried product.
The present invention also provides a homogeneous formulation comprising dried alone and at least one items selected from the group consisting of foods, food extracts, herbs, herb extracts, vitamins, and supplements. In some embodiments, the homogeneity of the formulation is retained in such a way so that the self-life of the final product retain for at least three years.

OBJECT OF THE INVENTION
A primary object of the present invention is to provide a nutraceutical formulation that contributes to general human wellness and good health through a novel mixture of the pericarp, pulp, juice, bark, and root of the ingredients including Fructooligosaccharides, Extracts of Gooseberry, Acai Berry, Xanthone, Cranberry, Strawberry, Gojiberry, Cherry, Raspberry, Bilberry, Black Currant, Blueberry, Redberry, Elderberry, Huckle Berry, Mulberry, Stone Berry, Sea Buckthorn and Grape. The effectiveness of this mixture is heightened through the addition of flavoring in varying amounts as required.
Another object of the present invention is to provide a nutraceutical formulation that offers the holistic benefits of the ingredients including Fructooligosaccharides, Extracts of Gooseberry, Acai Berry, Xanthone, Cranberry, Strawberry, Gojiberry, Cherry, Raspberry, Bilberry, Black Currant, Blueberry, Redberry, Elderberry, Huckle Berry, Mulberry, Stone Berry, Sea Buckthorn and Grape and is an efficacious source of natural highly absorbing vitamin, minerals and compounds (not synthetic compounds) with antimicrobial, anti-inflammatory, antioxidative, antibacterial and nutritional properties.
The foregoing and other objects, advantages and characterizing features will become apparent from the following description of certain illustrative embodiments of the invention.
While the methods and processes of the present invention have proven to be particularly useful in the area of nutritional health supplements, those skilled in the art can appreciate that the methods and processes can be used in a variety of different applications and in a variety of different areas of manufacture to satisfy a wide-ranging variety of food / dietary supplement, pharmaceutical and medicinal needs.

DETAILED DESCRIPTION OF THE INVENTION
The present invention relates to nutraceutical formulations derived from the ingredients Fructooligosaccharides, Extracts of Gooseberry, Acai Berry, Xanthone, Cranberry, Strawberry, Gojiberry, Cherry, Raspberry, Bilberry, Black Currant, Blueberry, Redberry, Elderberry, Huckle Berry, Mulberry, Stone Berry, Sea Buckthorn and Grape. In particular, the formulations of the invention described herein uniquely provide natural compounds through the combination of the pulp, pericarp, bark and root of the aforesaid ingredients and other phytochemical ingredients. The invention also relates to processes for manufacturing the nutraceutical formulations described herein in an economical manner.
Unless defined otherwise, all technical and scientific terms used herein have the same meanings as commonly understood by one of ordinary skill in the art to which this invention belongs. Preferred methods, formulations, and materials of the present invention are described herein, although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention. All references cited herein are incorporated by reference in their entirety.

Brief description of the ingredients and their uses:

FRUCTOOLIGOSACCHARIDES (FOS)
Fructooligosaccharides (FOS) are composed of short fructose chains. They are a type of carbohydrate called oligosaccharides. FOS occur naturally in many plants, which include:
• blue agave
• yacon root
• garlic
• onion
• leeks
• chicory root
• Jerusalem artichokes
• asparagus
• bananas
Fructooligosaccharides are subtly sweet and low-calorie. They are nondigestible, so they don’t have an effect on blood sugar levels. FOS may also have multiple health benefits.
FOS are used primarily as a low-calorie, alternative sweetener. People can eat and drink products made with FOS instead of those containing sugar, which spike glucose levels in the blood, and cause weight gain. FOS may also be preferable to artificial sweeteners, some of which have been linked to everything from weight gain, to diabetes.
The FOS are pre-biotic because they are not digestible, FOS travels intact through the small intestine to the colon (large intestine), where they support the growth of healthy bacteria in the digestive tract.

GOOSEBERRY
Indian gooseberry is known by two scientific names — Phyllanthus emblica and Emblica officinalis. It’s also commonly called amla.
This small tree has yellow-green flowers that blossom into round, edible fruits of the same color. The fruits are about the size of a golf ball with a pit and thin peel. Their taste has been described as sour, bitter, and astringent. The fruit is used in cooking in India, and most supplements on the market today are made only from the powdered, dried fruit or fruit extracts. However, the whole plant including the fruit, leaves, and seeds is utilized in traditional Indian medicine.

Heartburn - Researchers observed that the amla fruit group experienced greater reductions in the frequency and severity of heartburn and vomiting than those in the placebo group.
Anti-aging - Due to its high vitamin C content, Indian gooseberry may have some promising anti-aging benefits. Vitamin C is an antioxidant that can help prevent cellular damage, which may help slow your body’s natural aging process.
Some anti-aging benefits of Indian gooseberry include:
• Skin - In addition to its antioxidant activity, Indian gooseberry may help prevent the breakdown of collagen, which forms the firm but flexible protein matrix in your skin and soft
• Hair - Indian gooseberry extract is commonly used in Thailand to promote hair growth, and some evidence shows that it may inhibit an enzyme that contributes to hair loss.
• Vision - In test-tube studies, Indian gooseberry extract protected against age-related macular degeneration (AMD) by improving the mitochondrial health of eye cells.
Cancer - In test-tube and animal studies, Indian gooseberry extracts have killed certain types of cancer cells, including breast, cervical, ovarian, and lung cancers.
Additionally, Indian gooseberry extracts may play a role in cancer prevention due to their antioxidant activity. It appears that Indian gooseberry may also help prevent cell mutations that lead to tumor growth and cancer development.
It’s thought that the many phytochemicals, such as tannins and flavonoids, in Indian gooseberries play a role in cancer prevention, along with its vitamin C and antioxidant content.
Heart health - One of the most common uses of Indian gooseberry is to promote heart health. There are many ways in which Indian gooseberry may decrease your risk of heart disease, including:
• Antioxidant effects - Indian gooseberry extracts may protect against oxidative damage that’s associated with heart injury. This has been noted in several animal studies.
• Regulates endothelial function - A study in people with type 2 diabetes found taking 1,000 mg of Indian gooseberry daily improved endothelial function to the same extent as the drug atorvastatin.
• Anti-inflammatory effects - Human studies have noted that Indian gooseberry can significantly reduce inflammation, which is considered a key factor in the development of heart disease.
• Normalizes blood fat levels - Human studies have observed improved blood fat profiles after supplementing with Indian gooseberry, including lower triglyceride and total and LDL (bad) cholesterol, as well as increased HDL (good) cholesterol.
• Reduces blood pressure - Indian gooseberry may help reduce high blood pressure levels by acting as a vasodilator, or by widening the blood vessels. High blood pressure is a risk factor for heart disease.
• Anti-platelet effects - Finally, supplementing with Indian gooseberry may help prevent the formation of blood clots, which may cause a heart attack or stroke if they block an artery.
Liver damage - In rat studies, Indian gooseberry extract protected against liver damage caused by either a high fat diet or N-nitrosodiethylamine, a substance that’s toxic to the liver. This is likely due to its anti-inflammatory and antioxidant activity.
Immune health - Indian gooseberry may have some immune-strengthening effects due to its vitamin C content. A single Indian gooseberry contains approximately 600–800% of the Daily Value (DV) for this vitamin.
Vitamin C can optimize immune health in several ways. It’s an antioxidant, so it works to decrease cellular damage and inflammation.
It may also help your body develop protective antibodies against perceived threats.

ACAI BERRY
Acai (Euterpe oleracea) is a palm tree found throughout South America. Its berries are dark purple and used to make medicine.
Acai contains antioxidants which are thought to protect cells from damage. Acai berries are believed to have more antioxidant content than cranberry, raspberry, blackberry, strawberry, or blueberry. Chemicals in acai might also reduce swelling, lower blood sugar levels, and stimulate the immune system.
People commonly use acai for athletic performance, high cholesterol, erectile dysfunction (ED), obesity, aging skin, metabolic syndrome, and many other conditions.

XANTHONE (Mangosteen)
Xanthones, from the pericarp, whole fruit, heartwood, and leaf of mangosteen (Garcinia mangostana Linn., GML), are known to possess a wide spectrum of pharmacologic properties, including antioxidant, anti-tumor, anti-allergic, anti-inflammatory, anti-bacterial, anti-fungal, and anti-viral activities.
Mangosteen is also called the "QUEEN OF FRUITS" & Food of Gods and is a rich source of antioxidants and vitamin C. It has been found that its extract can neutralise up to 20–30 times more free radicals than any other natural sources. Mangosteen is good in vitamin C which is a powerful water soluble ANTIOXIDANTS. Mangosteen helps to strengthen the immunity system.
It promotes joint & cartilage function supports a strong respiratory system and help in maintaining good health. The active therapeutic compound found in Mangosteen is called “XANTHONES”. Xanthones are a family of phytonutrients loaded with potent of health benefits and antioxidants properties. Xanthones in Mangosteen have the ability to eradicate and destroy cancer cells. The mangosteen fruit is said to containsatleast 43 known Xanthones, majority of which are found in the fruit wall or pericarp of the fruit.
Xanthones work to reduce oxidative stress caused by free radicals. By damaging the free radicals, these antioxidants protect the body from various diseases, ranging from common cold and Flu, Cancer risk and Heart disorders.
There are over 200 XANTHONES found in nature. Mostly in wood, lichens and moss, which are mostly unpalatable and inedible. But 43 of them are in the Mangosteen, 3 in pulp and 40 in the pericarp. The highest recorded amount of XANTHONES present in Mangosteen than anything else. Xanthones represents the very latest that nutritional science has to offer. Much more than a great Antioxidants, Xanthones are a class of multi-functional phytonutrients poised to raise the bar in the nutritional arena ! At our company, we have not only launched a category creator, we are the next generation of supplementation.
Mangosteen provides powerful support for every organ system in the human body. This fact is being confirmed on a daily basis by clinical experience.
“Mangosteen is the most successful food supplement ever." - J. Frederic Temple man, M.D., a primary care physician for more than 20 years and board certified in both the United States and Canada.
"Mangosteen provides huge health benefits for every organ in our bodies."- Sam Walters, N.M.D., a family practitioner trained as a specialist in both traditional and natural medicine, with more than 30 years of comprehensive practical experience in the medical profession, and formulated nutritional products for companies and institutions including the NASA Space Center for the astronauts.
Mangosteen contains more than 40 biologically-active, natural chemical compounds called Xanthones. While all these Xanthones have similar molecular structures, each one has its own unique chemical formulation that permits it to perform a specific function. Alpha-mangostin, for example, is a very potent antioxidant. Gamma-mangostin is a powerful anti-inflammatory. Garcinone E is a strong anti-tumor agent. These and the other Xanthones found in the Mangosteen provide a virtual medicine chest of natural healing compounds that address a wide variety of health issues.
Centuries of Mangosteen use has helped Southeast Asians maintain or regain their health and cure their diseases. Traditional Asian healers use the fruit to stop infection, treat inflammation, and increase one's energy, among others.
Modern scientists and a growing number of health practitioners now agree on the medical benefits of Mangosteen. They have found that the fruit is helpful in preventing and possibly even stopping a wide range of diseases such as diabetes, heart disease, Alzheimer's disease, cancer and other chronic diseases.
Those who have taken the time to do their own research on the validity of each health benefit of Mangosteen will find that there is real and solid science behind the "Queen of Fruits".
Mangosteen contains powerful antioxidants and immune system boosters called Xanthones, natural chemical compounds which were proven to possess a variety of potent medicinal properties.
Xanthones occupy a special place in the Mangosteen's arsenal of healing compounds. They have been shown to have more potent antioxidant activity than vitamin E, one of nature's most powerful known antioxidants.
A laboratory test known as ORAC (Oxygen Radical Absorbance Capacity), for example, showed that an ounce of Mangosteen extract provides 20 to 30 times more capacity to absorb free radicals than an ounce of most fruits and vegetables.
Mangosteen also contains other potent natural compounds like catechism, polysaccharides, quinines, stilbenes and polyphenols.
Catechism were discovered to be five times more potent as antioxidants than vitamin C.
Polysaccharides are highly potent anti-cancer and anti-bacterial plant compounds. They help block a mutated cells ability to stick to healthy cells to help stop the spread of cancer, and are especially effective against intracellular bacteria.
Quinones are known for their anti-bacterial properties and also are strong antioxidants. Stilbenes in plants defend these plants against fungi. Interestingly, stilbenes also maintain their anti-fungal properties even when ingested. They also are strong antioxidants.
Polyphenols were found to be far more potent as antioxidants than vitamin E, considered one of the most powerful known antioxidants.
• Anti-aging - helps prevent aging
• Anti-allergenic - helps prevent allergic reactions
• Anti-arthritic – helps prevent arthritis
• Anti-atherosclerotic - helps prevent the hardening of the arteries
• Antibiotic - prevents or modulates bacterial infections
• Anti-calculi tic - helps prevent kidney stones
• Anti-cataract - helps prevent cataracts
• Antidepressant – helps with depression
• Anti-diarrheal – helps with diarrhea
• Anti-fatigue - helps relieve fatigue
• Antifungal - prevents or modulates fungal infections
• Anti-glaucoma - helps prevent glaucoma
• Anti-Inflammatory – helps with inflammation
• Anti-lipid emic - helps lower blood fat
• Anti-neuralgic - helps in nerve pain
• Anti-obesity - helps in weight loss
• Anti-osteoporosis - helps prevent the loss of bone mass
• Antioxidant-rich – rich in antioxidants
• Anti-Oxo lytic - anti-anxiety
• Anti-Parkinson - helps with Parkinson's disease
• Anti-periodontics - helps prevent gum disease
• Antipyretic - helps lower fever
• Anti-tumor and cancer-preventive
• Anti-vertigo - helps prevent dizziness
• Antiviral - prevents or modulates viral infections
• Cardio-protective - helps in the protection of the heart
• Hypoglycemic - helps stabilize blood sugar
• Hypotensive - helps lower blood pressure
• Immunostimulant – helps the immune system fight infection

CRANBERRY
Cranberries are small, round, deep-red berries related to the blueberry. They have a very sharp, sour taste, so are rarely eaten raw. They are more commonly enjoyed dried or juiced.
Cranberries grow on vine-like plants similar to strawberries and typically come from North America or eastern Europe.
There are several health benefits in Cranberries which are given hereunder:
1. Rich in antioxidant compounds - Cranberries contain plant compounds that have a protective antioxidant effect. Most of these are found in the skin of the berry and may as a result be lost during the juicing process.
2. Prevent urinary tract infections - Cranberry juice is probably most well-known for its management of urinary tract infections (UTIs). Cranberries contain compounds known as proanthocyanidins, which have natural antibacterial and may help prevent the bacteria Escherichia coli from attaching to the inner surface of the bladder and urinary tract, causing an infection.
3. Support heart health - A number of human studies support regular consumption of the juice or an extract of the berry to be beneficial for heart health, reducing a number of the key risk factors for heart disease. These include improving cholesterol balance, lowering blood pressure and reducing a compound called homocysteine, which is known to damage the lining of the blood vessels. However, it’s worth noting that some conflicting findings have been reported from other similar studies.
4. Protect against gastric ulcer and stomach cancer - Cranberries contain a plant compound that may reduce the risk of gastric ulcers and stomach cancer caused by the bacterium Helicobacter pylori. Consuming cranberry products, which are naturally rich in this compound (known as A-type pro-anthocyanidins), appears to suppress the growth of the bacteria and as a result reduce the risk of developing stomach cancer.
5. Protect against certain cancers - Cranberries are one of the best food sources of ursolic acid, a plant compound with antioxidant, anti-inflammatory and potential anti-cancer effects. It has been seen to be particularly useful in prostate cancer.

STRAWBERRY
Strawberries are rich in vitamin C and other antioxidants, which help reduce the risk of serious health conditions like cancer, diabetes, stroke, and heart disease. It's also an excellent source of Magnesium.
Health Benefits:
The vitamins, minerals, and antioxidants in strawberries can provide important health benefits. For example, strawberries are rich in vitamin C and polyphenols which are antioxidant compounds that may help to prevent the development of some diseases.
Insulin sensitivity:
The polyphenols in strawberries have been shown to improve insulin sensitivity in non-diabetic adults. Not only are strawberries low in sugar themselves, but they may also help you metabolize other forms of glucose.
Skin protection:
Strawberries have anti-inflammatory effects that may prevent skin damage when applied topically. In one small study, strawberry-based cosmetic treatments protected skin exposed to harmful ultraviolet A (UVA)-radiation, especially in combination with coenzyme Q10.
Osteoarthritis management:
One small study showed the anti-inflammatory benefits of strawberries can also protect other parts of the body, including the joints. For people with osteoarthritis and knee pain, strawberries can help reduce pain and swelling and improve quality of life. In one study, adults who ate 50 grams of strawberries each day for 24 weeks experienced an overall reduction in pain and inflammation.

GOJIBERRY
The gojiberry, also called the wolfberry is a bright orange-red berry that comes from a shrub that's native to China. In Asia, gojiberries have been eaten for generations in the hope of living longer.
Over time, people have used gojiberries to try to treat many common health problems like diabetes, high blood pressure, fever, and age-related eye problems. Gojiberries, which some brand a “superfood,” are eaten raw, cooked, or dried (like raisins) and are used in herbal teas, juices, wines, and medicines.
Health Benefits of Gojiberries:
Gojiberries are rich in nutrients. Some early studies using gojiberry juice found there may be some possible benefits that included:
• A feeling of well-being and calmness
• Better athletic performance
• Better sleep
• Weight loss
• A boost to your immune system
• Higher antioxidant levels

CHERRY
Cherries are small stone fruits that come in a variety of colors and flavors. There are two major categories — tart and sweet cherries, or Prunus cerasus L. and Prunus avium L., respectively.
All varieties are highly nutritious and packed with fiber, vitamins, and minerals.
One cup (154 grams) of sweet, raw, pitted cherries provides (1Trusted Source):
• Calories: 97
• Protein: 2 grams
• Carbs: 25 grams
• Fiber: 3 grams
• Vitamin C: 18% of the Daily Value (DV)
• Potassium: 10% of the DV
• Copper: 5% of the DV
• Manganese: 5% of the DV
These nutrients, particularly fiber, vitamin C, and potassium, benefit health in many ways. Vitamin C is essential for maintaining your immune system and skin health while potassium is needed for muscle contraction, nerve function, blood pressure regulation, and many other critical bodily processes.
Cherries are also a good source of fiber, which helps keep your digestive system healthy by fueling beneficial gut bacteria and promoting bowel regularity. They provide B vitamins, manganese, copper, magnesium, and vitamin K.

RASPBERRY
Raspberries are a small, sweet fruit with a tart undertone. Their cheerful pop of color and delicious flavor can make any ordinary meal feel special. And, each delicate raspberry is packed with vitamins, minerals, antioxidants, and fiber.
Raspberries can be found in four different colors: red, black, purple, and gold. Red raspberries are the most common type found at the grocery store. Fresh raspberries are generally available from June to October, but frozen raspberries are available year-round and contain the same amount of vitamins and minerals.
In addition, raspberries can also offer substantial health benefits.
Health Benefits:
Raspberries pack a lot of nutrition into a small space. They provide potassium, essential to heart function, and proven to lower blood pressure. The omega-3 fatty acids in raspberries can help prevent stroke and heart disease. They also contain a mineral called manganese, which is necessary for healthy bones and skin and helps regulate blood sugar.
Diabetes Management:
Raspberries contain much less sugar than most fruits — just 5 grams in an entire cup, making them less likely to raise your blood sugar levels.
Raspberries add a sweet taste to dishes, which can reduce your desire to sweeten food with artificial preservatives helping you lose weight and control your bood sugar levels.
Disease Prevention:
Raspberries are high in antioxidants that can protect cells from damage by free radicals. Free radicals are unstable atoms that injure your cells as they try to stabilize. The damage they cause may play a role in the aging process, arthritis, cancer, heart disease, alzheimer’s disease, and many other conditions.
Antioxidants stabilize free radicals, making them harmless. Fresh raspberries are among the top sources of antioxidants for your diet. Black raspberries offer the most antioxidants, followed by red and then golden raspberries. The deeper the color, the more antioxidants the berry contains.
Healthy Skin:
Raspberries also contain Vitamin C, which is vital to collagen production, a protein that makes up 75% of your skin. As you age, collagen decreases, causing wrinkles and sagging.
Raspberries are loaded with Vitamin C, which may also help prevent and repair skin damage from the sun.

BILBERRY
Bilberry is a type of dark blue-skinned berry native to Europe. It is sometimes called whortleberry, huckleberry, or blaeberry. Today, the bilberry grows in countries outside of Europe, including certain regions of the United States.
At first glance, the bilberry looks similar to the blueberry. The two berries are closely related and share similar nutritional values, but they do have some distinct traits.
One of the most noticeable differences between the two berries is the color of the flesh when they’re in season. Where blueberries have a greenish color inside their dark blue skins, bilberries have a red or purple color. In addition to their differences in color, bilberries also have a more acidic flavor than blueberries.
These berries might be small, but they provide many amazing health benefits.
Health Benefits
Like other types of berries, bilberries have many health benefits. Bilberries contain several plant compounds that can help fight inflammation, improve heart health, prevent diabetes, reduce the risk of cancer, and more.
The health benefits of bilberries include:
Eye health - If left untreated, glaucoma can eventually lead to a gradual loss of eyesight. The anthocyanins in bilberries can help improve eye function for people with normal-tension glaucoma. Some studies suggest bilberries may help with eye fatigue, which can lead to eye strain, headaches, shoulder tension, and blurred or double vision.
Reduced risk of diabetes
Bilberry and bilberry extract can help lower blood sugar levels in people with diabetes. The berries may also help increase insulin secretion in people with metabolic syndrome.
Reduced risk of heart disease
Bilberries contain vitamin K, which can help prevent blood clots that could cause a heart attack or stroke. The anthocyanins in bilberries may also help reduce cholesterol and lower blood pressure. Managing your cholesterol levels and blood pressure can reduce your risk for artherosclerosis and other heart-related problems.
Cancer prevention
Bilberry is full of vitamin C, anthocyanins, and other antioxidants that help fight free radicals in your body. By protecting against free radicals and cell damage, bilberries may help reduce your risk of developing certain types of cancer.

BLACK CURRANT
Black Currant is very popular in preventing Alzheimer’s disease, arthritis, gout and liver problems also helpful in the menopause, painful periods, PMS and also against diarrhoea.
It has antibacterial, antioxidant and antiviral properties which may useful in slowing the growth of cancer, helps in preventing eye disease, strengthen immune system.
Health benefits of Black Currant:
• Rich in Anthocyanins
• Helps Reduce Cancer Growth
• Promotes Eye Health
• Boosts Immunity
• Protects Against Pathogens
• May Prevent Herpes Outbreaks
• Keeps Our Cardiovascular System Healthy
• Helps in Controlling High Blood Pressure
• Is a high Source of Omega-3 Fatty Acid
• Provides Anticarcinogenic Benefits
• Helps in Fighting Infections
• Provides Antibacterial Benefits
• Good for Our Brain
• Reduces the Risk of Anemia
• Provides Relief From From Gastrointestinal and Cardiovascular
Inflammation
• Good for Our Eyes
• Assist in Energy Production
• Provides Herbal Benefits
• Provides Anti-Inflammatory Benefits
• Excellent Source of Vitamin C
• Helps in Controlling Blood Sugar Level
• Provides Relief from Insomnia
• Provides Relief from Constipation
• Provides Anti-viral Benefits
• Beneficial For Individuals Suffering From PAD (Peripheral Arterial
Disease) Provides Relief from Circulatory problems

BLUEBERRY
The blueberry (vaccinium myrtillus) was one of the first foods to be titled a ‘superfood’. There are many varieties growing in different regions of the world; the berries grow in clusters on shrubby bushes and can range in size.
1. Prevent heart disease:
Research has shown that anthocyanidins, which are found in berry fruits, may support the cardiovascular system. They appear to do this by supporting the health of blood vessels and reducing the arterial stiffness which is associated with ageing.
2. Regulate blood sugar:
Blueberries are both low in sugar and a good source of fibre, as a result they have a low Glycaemic Index (GI). This, together with their high flavonoid content, may help improve insulin sensitivity which is important for managing blood sugar levels.
3. Maintain eye health:
Including blueberries regularly in your diet may improve vision and guard against age-related macular degeneration. This is thought to be thanks to the improved blood and oxygen flow to the eyes and the antioxidant protection which may help reduce the likelihood of cataract and macular degeneration.
4. Alleviate gastrointestinal issues and UTIs:
Traditional medicine suggests blueberries may be a useful remedy for both gastrointestinal conditions and urinary tract infections.

REDBERRY
Red berry fruits such as elderberry, chokeberry and bilberry have been used for centuries to cure a wide range of problems such as dysentery, stomach ailments, scurvy and rheumatism, but several recent studies have focused primarily on their effects on the arteries.

ELDERBERRY
Elderberry fruit contains high levels of flavonoids, which means it might have anti-inflammatory and antioxidant properties. These help to protect healthy cells from harmful free radicals that play a role in skin problems.
Used for its antioxidant activity to lower cholesterol, improve vision, boost the immune system, improve heart health and for coughs, colds, flu, bacterial and viral infections and tonsillitis. Elderberries have been a folk remedy for centuries in North America, Europe, Western Asia, and North Africa, hence the medicinal benefits of elderberries are being investigated and rediscovered. Bioflavonoids and other proteins in the extract destroy the ability of cold and flu viruses to infect a cell. People with the flu who took elderberry extract reported less severe symptoms and felt better much faster than those who did not.
Elderberries contain organic pigments, tannin, amino acids, carotenoids, flavonoids, sugar, rutin, viburnic acid, vitamin A and B and a large amount of vitamin C. They are also mildly laxative, a diuretic, and diaphoretic. Flavonoids, including quercetin, are believed to account for the therapeutic actions of the elderberry flowers and berries. According to test tube studies these flavonoids include anthocyanin’s that are powerful antioxidants and protect cells against damage.
Elderberries were listed in the CRC Handbook of Medicinal Herbs as early as 1985, and are listed in the 2000 Mosby's Nursing Drug reference for colds, flu, yeast infections, nasal and chest congestion, and hay fever. In Israel, Hadassah’s Oncology Lab has determined that elderberry stimulates the body's immune system and they are treating cancer and AIDS patients with it.
Elderberries contain high levels of vitamin A, which helps soothe the skin, help ease the appearance of age spots, and prevent or lessen wrinkles.
People have used elderberries for their potential health-boosting properties for many years, most notably to fight colds and the flu.
Elderberries contain high levels of fibre. Consuming elderberries as part of a healthful diet may lead to some health benefits, including protection from cardiovascular disease and colorectal cancer.

HUCKLE BERRY
Huckleberries are small blue berries that look very similar to blueberries. Like other berries, huckleberries are rich sources of vitamin A, B vitamins and vitamin C, as well as various antioxidants.
Research shows that huckleberry has a very high phytochemical content, especially the antioxidants called anthocyanin and polyphenols.
One study found that huckleberries contain up to 15 anthocyanins, including
• galactoside
• glucoside
• arabinoside of delphinidin
• cyanidin
• petunidin
• peonidin
• malvidin
The darker blue- and purple-colored varieties seem to be especially rich in these antioxidants.

MULBERRY
Mulberries are the fruits of mulberry trees (Morus sp.) and related to figs and breadfruit. They carry colorful berries — most commonly black, white, or red.
Mulberries are often consumed dried, similar to raisins. In this form, they contain 70% carbs, 14% fiber, 12% protein, and 3% fat — making them fairly high in protein compared to most berries.
Mulberries are rich in many vitamins and minerals, particularly vitamin C and iron.

STONE BERRY
Like other berries Stone Berry are high-antioxidant foods, which are important compounds that can help fight free radicals to protect against cell damage and disease. In fact, studies show that antioxidants may play a central role in the development of chronic conditions, such as heart disease, cancer and diabetes.

SEA BUCKTHORN
Sea buckthorn is a shrub native to China and areas of Europe. It contains many medicinal compounds, as well as nutrients that include Vitamins, Amino acids, Fatty acids, Minerals.
Sea buckthorn is thought to remove free radicals -- molecules that can damage cells. Most scientific evidence is from animal studies. Though not proven in human clinical trials, people say they take sea buckthorn specifically to try to:
• Treat stomach or intestinal problems
• Improve blood pressure or blood cholesterol
• Prevent or manage blood vessel or heart disease
• Complement cancer treatment
• Boost immunity and prevent infections
• Treat obesity
• Improve symptoms of cirrhosis
• Improve eyesight or dry eyes
• Treat respiratory problems such as asthma, colds, and pneumonia
People also use sea buckthorn as a sunscreen or cosmetic, and for a variety of skin problems such as radiation damage, exanthemata, a skin rash usually found in children, Bedsores, burns, or cuts, Acne, dermatitis, or dry skin.

GRAPE
Grapes offer a wealth of health benefits, primarily due to their high nutrient and antioxidant contents.
Grapes are a rich source of copper and vitamin K. Copper is an essential mineral involved in energy production, while vitamin K is vital for blood clotting and healthy bones (2 Trusted Source, 3 Trusted Source).
Grapes also provide good amounts of B vitamins like thiamine, riboflavin, and B6. Both thiamine and riboflavin are needed for growth and development, while B6 is mainly required for protein metabolism
It has been found that utilization of the above-mentioned method with combinations of products results in a dehydrated composition that is homogeneous and resistant to separation of the components. That is, the ratio of the components is retained in the dried product. The method produces a dehydrated product with a density similar to that obtained by spray-drying / sun drying and the like, but with retention in heat-labile constituents similar to that obtained via freeze-drying.
Products which may be utilized in the combinations for drying include but are not limited to berries, fruits, herbs, vitamins, barks, roots, nuts, legumes, and extracts or purified extracts of berries, fruits, herbs, vitamins, barks, roots, nuts, or legumes including Fructooligosaccharides, Extract (Gooseberry, Acai Berry, Xanthone, Cranberry, Strawberry, Gojiberry, Cherry, Raspberry, Bilberry, Black Currant, Blueberry, Redberry, Elderberry, Huckle Berry, Mulberry, Stone Berry, Sea Buckthorn, Grape),
The extracts of any of aforesaid ingredients may be liquefied by any process, filtered or unfiltered and combined. In some embodiment, the extracts are combined in a ratio of less than 1% to greater than 99% in the liquid form. The liquid combinations are then dried using the methods of the invention to form a gel, a film, a flake, or a powder that retains the original homogeneity of the liquid. The form of the dried product depends on several factors, such as composition of original components, temperature of drying, residence time on the dryer, moisture content of the product, and polysaccharide content of the product. For example, products with higher polysaccharide content tend to result in more filmlike products. In some embodiments of the invention, the form of the dried product may be controlled by controlling the above-mentioned factors. For example, if a film is desired, then polysaccharide may be added to the liquid composition. Films may be converted to flakes or powders, and flakes may be converted to powders with further processing of the dried product.
Homogeneity of the product may be determined by methods known to those skilled in the art. It is known in the art that dry blends containing different combinations of food, herbs, supplements or extracts of food or herbs can experience separation of constituents due to different densities even when particle size is similar. Such separations occur, for example, during transport of the mixtures. The present combinations of dried blends, however, do not undergo a separation of constituents under these circumstances. In some embodiments, the homogeneity of the dried product is retained for at least about three years.
The dried blends of the present invention can be used in a variety of applications. The combinations of ingredients or purified extracts of said ingredients remain homogeneous in dehydrated form will improve the ease of formulations and standardize the constituents of the product. Standardization of constituents will improve the dependability of sensory attributes, nutrients and bioactivities of the combinations. Bioavailability of nutrients may be improved in the presence of aloe and the nutritional value of the foods, supplements or extracts. The dried products may be reconstituted with water. The dried blends can be used as a preformulation for the preparation of food, supplemental, therapeutic or cosmetic products.
The dried blends of the present invention may be used in compositions for various uses, such as therapeutic, cosmetic, and nutritional uses. For example, the dried blends may be formulated in a composition that contains a therapeutic agent. The therapeutic agent may be present either as part of the dried blend, or as part of a further composition.
As noted above, the dried composition of the present invention can be present in various drug delivery system, including gels, films, flakes, and powders. The form of the dried composition will inform the addition of other components for a particular use. If necessary the composition may be milled at any suitable stage of the process. A suitable sterilization procedure may also be included if necessary. Alternatively raw materials are obtained in sterile condition and the compositions are produced aseptically.
In an another embodiment of the invention, the end-product(s) is suitable for use in the form of powder, granules, suspension, tablets or capsules etc.
One more embodiment of the invention, relates to a process for the preparation of herbal health protective, promotive and preventive nutraceutical composition(s) useful as food supplements to ameliorate the general health with optimum nutrients and also help to control the blood sugar level and disease related problems, the said process comprising:
a. selecting seed from the ingredients including Fructooligosaccharides, Extract (Gooseberry, Acai Berry, Xanthone, Cranberry, Strawberry, Gojiberry, Cherry, Raspberry, Bilberry, Black Currant, Blueberry, Redberry, Elderberry, Huckle Berry, Mulberry, Stone Berry, Sea Buckthorn, Grape),
b. drying the ingredients for 2 to 15 minutes under microwave conditions having frequency 1500–2500 MHz, powdering the roasted seeds to a mesh size of 50–400 and mixing the ingredient powders in definitive proportions.,
c. obtaining powder or extract of the said ingredients including selecting seed from the ingredients including Fructooligosaccharides, Extract (Gooseberry, Acai Berry, Xanthone, Cranberry, Strawberry, Gojiberry, Cherry, Raspberry, Bilberry, Black Currant, Blueberry, Redberry, Elderberry, Huckle Berry, Mulberry, Stone Berry, Sea Buckthorn, Grape), and
d. drying the extract to obtain a residue, mixing the plants extract residue with the base product to get the final nutraceutical product(s), and
e. optionally adding some additives selected from conventional flavoring agents to obtain nutraceutical product(s).
In another embodiment of the invention, the roasted seeds are powdered separately to pass through sieves having mesh size ranging from 50 to 400.
In another embodiment of the invention, the amount of dried ingredient powders are mixed in various proportions ranging up to 40% by weight and parts of plants used are selected from roots, fruits, seeds, leaves, wood and whole plant of herbs/medicinal plants ranging up to 40% by wt. are selected for use in the nutraceutical product(s).
In yet another embodiment of the invention, the said powdered ingredient mixture is extracted with aqueous alcohol in the range of 5 to 95% v/v thrice for 5 to 48 hours, at temperature ranging from 20 to 50° C.
In yet another embodiment of the invention, the alcohol is selected from methanol, ethanol, propanol, isopropanol and butanol.
In yet another embodiment of the invention, the said solvent from combined extractives is removed under reduced pressure ranging from 10 to 150 PSI at temperature ranging from 20 to 80°C. and the viscous residue thus obtained is called as plants extract.
In yet another embodiment of the invention, the plants extract is suspended in ethanol-water mixture from 0 to 90% v/v in the ratio ranging from 10 to 30% by stirring for 5 to 60 minutes.
In yet another embodiment of the invention, the mixture of ingredient powder’s are mixed thoroughly in a mixer grinder for a period of ranging from 5 to 60 minutes.
In yet another embodiment of the invention, the mixture is dried for a period of ranging from 5 to 50 hours at temperature ranging from 20 to 50° C.
In yet another embodiment of the invention, the amount of optional additives used are in the range of 0.5 to 4% by wt,
In yet another embodiment of the invention, the dried combination of the pulp, pericarp, bark and roots of the ingredients are repeatedly mixed thoroughly in a mixer grinder for a period of ranging from 5 to 60 minutes and the powder thus obtained is used to prepare final nutraceutical(s).
In yet another embodiment of the invention, the said dried ingredients are mixed with in the ratio ranging up to 90% and more by wt. excluding the weight of additives like flavoring agents
In yet another embodiment of the invention, the said said composition is prepared by a process comprising the steps of obtaining powder or extract of the ingredients; drying the extract to obtain a residue for each ingredient; and mixing the residue in definite proportion with flavoring agents.
In yet another embodiment of the invention, the said n formulation is prepared by a process comprising the steps of Grinding the dried ingredients independently; Extracting the powdered ingredient(s) with aqueous alcohol in the range of 5 to 95% v/v water to alcohol for 5 to 48 hours at a temperature of 20 to 50° C.; and Filtered and distilled said solvents under reduced pressure at 20 to 80° C. in order to obtain extract of the ingredients; and finally mixing the extracts of all the ingredients in definite proportion with flavoring agents.
In yet another embodiment of the invention, the said composition is prepared by a process comprising the steps of grinding or powdering the dried ingredient(s); extracting the crushed or powdered herb with aqueous alcohol in the range of 5 to 95% v/v water to alcohol for 5 to 48 hours at a temperature of 20 to 50° C d, distilling said alcohol under reduced pressure at 20 to 80° C. in order to obtain extract the ingredient; andmixing extracts of all the ingredients in definite proportion with flavoring agents to obtain the product.
In yet another embodiment of the invention, the said extraction is carried out three times under same condition and distilled the combined extracts for efficient extraction.
In yet another embodiment of the invention, alcohol is selected from the group consisting of methanol, ethanol, iso-propanol, and butanol.
In yet another embodiment of the invention, flavoring powder up to 4% by wt is added to the said mixture.
In yet another embodiment of the invention, the nutraceutical formulations, as herein described for the composition, methodology, preparation of base material for nutrition and fortified with selected herbs/medicinal plants in the form of powders/extracts to get the value added end nutraceutical product(s) which may be used as health protective, promotive, food supplements to ameliorate the general health of the individual and to control chronic ailments in the form of powder, granules, syrups, suspension, tablets or capsules etc.
Use of the present compositions may also be in food products, including those envisioned for use as a dietary supplement such as a health bar. Beverage compositions using dried blends of the present invention may comprise a beverage member such as water, fruit juice, tea solids, milk solids, fruit flavors, botanical flavors, and mixtures thereof. Water may be included in the compositions of the present invention, particularly wherein the compositions are beverage compositions. As used herein, the term “water” includes the total amount of water present in the composition. “Water” includes water from flavor agents, sugar syrups, and other sources, e.g., gum solutions.
Dietary foods can be made with the dried compositions to meet special dietary needs, for example, of persons who are obese, diabetic, or hypercholesterolemic. The present compositions can be used alone or in combination with drug therapy, nutritional therapy, or other therapy. Combinations of food or beverage products made with the compositions can be used as part of a total dietary management regimen, based on one or more of these products, containing the compositions alone or in combination with one or more of the above-mentioned ingredients, to provide one or more of the above-mentioned benefits.

NUTRITIONAL FACTS:
The following table of the nutritional values are provided for illustrative purposes only and are not intended to limit the scope of the invention.

Particulars Per serve 6.2g in 200ml Per 100ml serve
Energy (Kcal) 10.52 05.26
Protein (g) 00.35 00.17
Fat (g) 00.00 00.00
Carbohydrates (g) 02.52 01.26
Added Sugar (g) 00.00 00.00
Fibre (g) 03.61 01.80

The above detailed description is to illustrate the specific best-mode embodiment of the present invention, but it is not intended to be limiting. Numerous modifications are possible within the scope of the present invention. The present invention is set forth in the accompanying claims.
, Claims:We Claim:

1. A nutraceutical composition consists of:
a dried powder of ingredients Fructooligosaccharides, Extracts of Gooseberry, Acai Berry, Xanthone, Cranberry, Strawberry, Gojiberry, Cherry, Raspberry, Bilberry, Black Currant, Blueberry, Redberry, Elderberry, Huckle Berry, Mulberry, Stone Berry, Sea Buckthorn and Grape comprising a combination of the pulp, pericarp, bark and roots of the ingredients with essential minerals such as Magnesium Carbonate, Magnesium Sulphate, Tri-Sodium Citrate, Potassium Chloride, Sodium Chloride, Acidity Regulator (E330), Sucralose (E955) and added flavour of natural flavouring substances, berries and lemon to make taste with pharmaceutically acceptable salts, and flavoring agents to prepare different drug delivery system.
2. The nutraceutical composition as claimed in claim 1, wherein the part of the herbal ingredients is pulp, pericarp, bark and roots.
3. The nutraceutical composition as claimed in claim 1, wherein the flavoring agents are conventional esters and carriers.
4. The nutraceutical composition as claimed in claim 1, wherein said composition is prepared by
a process comprising the steps of:
obtaining powder or extract of the ingredients;
Drying the extract to obtain a residue for each ingredient; and
Mixing the residue in definite proportion with flavoring agents as stated above.
5. The nutraceutical composition as claimed in claim 1, wherein composition is prepared by a process comprising the steps of:
a) Grinding the dried ingredients independently;
b) Extracting the powdered herb(s) with aqueous alcohol in the range of 5 to 95% v/v water to alcohol for 5 to 48 hours at a temperature of 20 to 50° C.; and
c) Filtering and distilling said solvents under reduced pressure at 20 to 80° C. in order to obtain extract of the ingredients; and
d) Mixing the extracts of all the ingredients in definite proportion with flavoring agents
6. The nutraceutical composition as claimed in claim 6, wherein the extraction is carried out three times under same condition and distilled the combined extracts for efficient extraction.
7. The nutraceutical composition as claimed in claim 6, wherein said alcohol is selected from the group consisting of methanol, ethanol, 2-propanol, and butanol or a mixture thereof.

Documents

Application Documents

# Name Date
1 202331023212-STATEMENT OF UNDERTAKING (FORM 3) [29-03-2023(online)].pdf 2023-03-29
2 202331023212-POWER OF AUTHORITY [29-03-2023(online)].pdf 2023-03-29
3 202331023212-FORM 1 [29-03-2023(online)].pdf 2023-03-29
4 202331023212-DECLARATION OF INVENTORSHIP (FORM 5) [29-03-2023(online)].pdf 2023-03-29
5 202331023212-COMPLETE SPECIFICATION [29-03-2023(online)].pdf 2023-03-29