ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER CROSS REFERENCE TO RELATED APPLICATION This application claims priority from United States the organic layer separated, washed once with water, once with saturated sodium chloride solution, filtered through a short pad of silica gel, and concentrated in vacuo to provide 1.1 g (91%) of the title compound as a colorless oil. 1H NMR (CDCl3) d 7.88 (d. J = 9 Hz, 1H) . 7.38 (t. J = 8 Hz, 1H), 7.22 (s 1H) , 7.12 (d, J = 9 Hz, 1H), 7.08 (d, J = 2 Hz, 1H), 6.80 (d, J = 9 Hz, 1H), 6.69 (d, J = 9 Hz, 1H). 6.45 (d, J = 9 Hz, 1H), 6.40 (s, 1H), 4.20 (t, J = 6 Hz, 2H), 4.11 (t, J = 6 Hz, 2H), 3.83 (s, 3H), 2.64 (t, J = 8 Hz, 2H), 2.54 (q, J = 7 Hz. 2H), 2.32 (quintet, J = 6 Hz, 2H), 1.54 (hextet, J = 8 Hz. 2H) , 1.13 (t, J = 7 Hz, 3H) , 1.03 (s, 9H), 0.89 (t, J = 7 Hz, 3H) , 0.23 (s, 6H). C. Preparation of 2-{3-[3-(2-ethyl-4-furan-2-yl-5- hydrophenoxy)propoxy]-2-propyl-phenoxy)benzoic acid methyl estar. A mixture of 2-(3-{3-[4-bromo-5-(tert- butyldimethylsilanyloxy) -2-ethylphenoxy]propoxy} -2- propylphenoxy)benzoic acid methyl ester (1.05 g, 1.60 mmol), furan-2-boronic acid (0.358 g, 3.20 mmol), tetrakis(triphenylphosphine)palladium(0) (0.185 g. 0.160 nsncl), and 2 M aqueous sodium carbonate solution (8 mL) in tetrahydrofuran (20 mL) was heated at reflux for 18 h. The mixture was cooled to room temperature, diluted with water, and extracted with ethyl acetate. The organic layer was separated, washed once with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 10% ethyl acetate/90% hexane) of the residue provided 0.8 g (94%) of the title compound as a colorless oil. 1H NMR (CDCl3) d 7.90 (d, J = 9 Hz, 1H), 7.48 (s, 1H), 7.38 (t, J = 8 Hz, 1H), 7.21 (s 1H), 7.13 (8, 1H), 7.10 (d, J = 9 Hz. 1H), 7.07 (d, J = 2 Hz, 1H), 6.81 (d, J = 9 Hz, 1H), 6.69 (d, J = 9 Hz, 1H), 6.52 (m, 3H), 6.44 (d, J = 9 Hz, 1H), 4.20 (m, 4H). 3.83 (s, 3H), 2.67 (t, J = 8 Hz, 2H), 2.59 (q, J = 7 Hz, 2H). 2.32 (quintet, J = 6 Hz, 2H), 1.55 (hextet, J = 8 Hz. 2H), 1.18 (t, J = 7 Hz, 3H), 0.91 (t, J = 7 Hz, 3H); MS ES- m/z = 589 (p + AcO-). Anal. Calcd for C32H34O7: C, 72.43; H, 6.46. Found: C, 72.21; H, 6.15. D- Preparation of 2-{3-[3-(2-ethyl-4-furan-2-yl-5- hydroxyphenoxy)propoxy]-3-propylphenoxy)benzoic acid sodium salt. 2-(3-[3-(2-Ethyl-4-furan-2-yl-5-hydroxyphenoxy)propoxy]-2- propylphenoxy}benzoic acid methyl ester (250 mg, 0.47 mmol) was dissolved in tetrahydrofuran (4 mL) and treated with 1 N lithium hydroxide solution (2 mL) at 50 °C for 16 h. The mixture was concentrated in vacuo and the residue diluted with water and extracted twice with ethyl acetate. The combined organic extracts were washed once with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. The residue was dissolved in ethyl acetate and shaken with 1 N hydrochloric acid. The organic layer was dried (sodium sulfate), filtered, and concentrated in vacuo. The residue was dissolved in diethyl ether and treated with 1 N aqueous sodium hydroxide solution (0.32 mL). The mixture was concentrated in vacuo and azeotroped successively with diethyl ether, chloroform, and diethyl ether and dried to provide 168 mg (66%) of the title product as a cream solid. 1H NMR (DMSO-d6) d 7.56 (s, 1H), 7.44 (d, J = 8 Hz, 1H) , 7.35 (s, 1H), 7.13 (m, 1H). 6.97 (m. 2H), 6.77 (d, J = 2 Hz, 1H), 6.65 (m, 4H), 6.48 (d, J = 2 Hz, 1H), 6.24 (d, J = 9 Hz, 1H), 4.15 (t, J = 6 Hz, 2H), 3.96 (t, J = 6 Hz. 2H), 2.66 (t, J = 8 Hz, 2H), 2.42 (q, J = 7 Hz, 2H), 2.13 (quintet, J = 6 Hz, 2H), 1.48 (hextet, J = 8 Hz, 2H), 1.09 (t, J = 7 Hz, 3H) . 0.84 (t, J = 7 Hz, 3H) ; TOF MS ES exact mass calculated for C31H33O7 (p+1): m/z = 517.2226. Found: 517.2230. IR (KBr, cm-1) 3400, 2961, 1599, 1460. Example 14 Preparation of 2-(3-{3-[2-Ethyl-5-hydroxy-4-furan-3- yl]phenoxy]propoxy)-2-propylphenoxy)benzoic acid. A. Preparation of 2-{3-[3-(2-ethyl-4-furan-3-yl-5- hydroxyphenoxy)propoxy]-3-propyl-phenoxy)benxoic acid methyl eater. A mixture of 2-(3-{3-[4-bromo-5-(tert- butyldimethylsilanyloxy) -2-ethylphenoxy] propoxy} -2- propylphenoxy)benzoic acid methyl ester (2.10 g, 3.19 mmol), furan-3-boronic acid (0.722 g, 6.45 mmol), tetrakis(triphenylphosphine)palladium(0) (0.37 g, 0.32 mmol), and 2 M aqueous sodium carbonate solution (16 mL) in tetrahydrofuran (30 mL) was heated at reflux for 48 h. The mixture was cooled to room temperature, diluted with water, and extracted with ethyl acetate. The organic layer was separated, washed once with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 15% ethyl acetate/85% hexane) of the residue provided 0.29 g (17%) of the title compound as a yellow oil. TOF MS ES+ exact mass calculated for C32H35O7 (p+1): m/z = 531.2383. Found: 531.2396. B. Preparation of 2-{3-[3-(2-ethyl-4-furan-3-yl-5- hydroxyphenoxy)propoxy]-2-propylphenoxy)benzoic acid sodium salt. 2-{3-{3-(2-Ethyl-4-furan-3-yl-5-hydroxyphenoxy)propoxy]-2- propylphenoxy}benzoic acid methyl ester (170 mg, 0.32 mmol) was dissolved in tetrahydrofuran (4 mL) and methanol (1 mL) and treated with 1 N lithium hydroxide solution (4 mL) at 50 °C for 2 h. The mixture was concentrated in vacuo and the residue acidified with hydrochloric acid and the resulting mixture extracted twice with ethyl acetate. The combined organic extracts were washed once with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 2% methanol/98% chloroform) of the residue gave 45 mg of material that was again submitted to chromatography (silica gel, 1% methanol/99% chloroform) to provide 25 mg (15%) of the title compound as an oil. TOF MS ES+ exact mass calculated for C32H33O7 (p+1): m/z = 517.226. Found: 517.2230. Example 15 Preparation of 2-(3-{3-[2-Ethyl-5-hydroxy-4- (tetrahydrofuran-3-yl)phenoxy]propoxy}-2- propylphenoxy)benzoic acid sodium salt hemihydrate. A. Preparation of 2-{3-[3-(5-benzyloxy-2-ethyl-4-furan-3- yl-phenoxy)propoxy] -2-propylphenoxy)benzoic acid methyl ester. A mixture of 2-{3-[3-(5-benzyloxy-4-bromo-2- ethylphenoxy)propoxy]-2-propylphenoxy}-benzoic acid methyl ester (3.00 g, 4.73 mmol), furan-3-boronic acid (1.06 g, 9.47 mmol), tetrakis(triphenylphosphine)palladium(0) (0.54 g, 0.47 mmol), and 2 M aqueous sodium carbonate solution (20 mL) in tetrahydrofuran (40 mL) was heated at 100 °C for 48 h. The mixture was cooled to room temperature, diluted with water, and extracted with ethyl acetate. The organic layer was separated, washed once with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 10% ethyl acetate/90% hexane) of the residue provided 1.9 g (65%) of the title compound as a yellow oil. 1H NMR (CDCl3) d 7.88 (dd, J = 8, 2 Hz, 1H), 7.87 (s. 1H), 7.40 (m, 7H), 7.26 (s 1H), 7.05 (m, 2H), 6.80 (d, J = 9 Hz. 1H), 6.76 (d. J = 2 Hz, 1H), 6.67 (d, J = 9 Hz, 1H), 6.60 (s, 1H), 6.43 (d, J = 9 Hz, 1H), 5.11 (s, 2H), 4.18 (m, 4H), 3.83 (s, 3H), 2.66 (t, J = 8 Hz, 2H), 2.62