Ophthalmic Solution Of Difluprednate

Abstract: The present invention provides an ophthalmic solution comprising therapeutically effective concentration of difluprednate, a crystal growth inhibitor and pharmaceutically acceptable amounts of a solubilizer comprising a mixture of quaternary ammonium compound and polyethoxylated castor oil, in an aqueous vehicle. The present invention further provides a method of enhancing the ocular bioavailability of difluprednate, said method comprising instilling an ophthalmic solution comprising therapeutically effective concentration of difluprednate, a crystal growth inhibitor and pharmaceutically acceptable amounts of a solubilizer comprising a mixture of quaternary ammonium compound and polyethoxylated castor oil, in an aqueous vehicle.

Patent Information

Application #

Filing Date

16 October 2015

Publication Number

16/2017

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

vinita.Kulkarni@sunpharma.com

Parent Application

Applicants

SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED

17/B, MAHAL INDUSTRIAL ESTATE, OFF MAHAKALI CAVES ROAD, ANDHERI (EAST), MUMBAI

Inventors

1. KHOPADE AJAY JAYSINGH

SPARC LTD., NIMA COMPOUND, NEAR PRATHAM ENCLAVE, TANDALJA, ROAD, BARODA-390 020, INDIA

2. HALDER ARINDAM

SPARC LTD. NIMA COMPOUND, NEAR PRATHAM ENCLAVE, TANDALJA, ROAD, BARODA-390 020

3. SHAH ANKIT SHAILESHKUMAR

SPARC LTD. NIMA COMPOUND, NEAR PRATHAM ENCLAVE, TANDALJA, ROAD, BARODA-390 020

Specification

Claims: , Description:

Documents

Application Documents

#	Name	Date
1	3932-MUM-2015-FORM-26 [26-11-2019(online)].pdf	2019-11-26
1	Description(Provisional) [16-10-2015(online)].pdf	2015-10-16
2	CERTIFIED COPIES TRANSMISSION TO IB [07-11-2016(online)].pdf	2016-11-07
2	3932-MUM-2015-PETITION UNDER RULE 137 [26-11-2019(online)].pdf	2019-11-26
3	CERTIFIED COPIES TRANSMISSION TO IB [08-11-2016(online)].pdf	2016-11-08
3	3932-MUM-2015-Response to office action (Mandatory) [26-11-2019(online)].pdf	2019-11-26
4	3932-MUM-2015-Form 5-171016.pdf	2018-08-11
4	3932-MUM-2015-Correspondence-251019.pdf	2019-10-28
5	3932-MUM-2015-Form 3-171016.pdf	2018-08-11
5	3932-MUM-2015-Abstract-171016.pdf	2018-08-11
6	3932-MUM-2015-Form 2-171016.pdf	2018-08-11
6	3932-MUM-2015-Claims-171016.pdf	2018-08-11
7	3932-MUM-2015-Form 2(Title Page)-171016.pdf	2018-08-11
7	3932-MUM-2015-CORRESPONDENCE-171016.pdf	2018-08-11
8	3932-MUM-2015-Description(Complete)-171016.pdf	2018-08-11
9	3932-MUM-2015-Form 2(Title Page)-171016.pdf	2018-08-11
9	3932-MUM-2015-CORRESPONDENCE-171016.pdf	2018-08-11
10	3932-MUM-2015-Claims-171016.pdf	2018-08-11
10	3932-MUM-2015-Form 2-171016.pdf	2018-08-11
11	3932-MUM-2015-Form 3-171016.pdf	2018-08-11
11	3932-MUM-2015-Abstract-171016.pdf	2018-08-11
12	3932-MUM-2015-Form 5-171016.pdf	2018-08-11
12	3932-MUM-2015-Correspondence-251019.pdf	2019-10-28
13	CERTIFIED COPIES TRANSMISSION TO IB [08-11-2016(online)].pdf	2016-11-08
13	3932-MUM-2015-Response to office action (Mandatory) [26-11-2019(online)].pdf	2019-11-26
14	CERTIFIED COPIES TRANSMISSION TO IB [07-11-2016(online)].pdf	2016-11-07
14	3932-MUM-2015-PETITION UNDER RULE 137 [26-11-2019(online)].pdf	2019-11-26
15	Description(Provisional) [16-10-2015(online)].pdf	2015-10-16
15	3932-MUM-2015-FORM-26 [26-11-2019(online)].pdf	2019-11-26