Sign In to Follow Application
View All Documents & Correspondence

Oral Composition With An Improved Teeth Whitening Effect

Abstract: The present invention relates to oral care compositions with an improved teeth whitening effect. This effect is achieved by inclusion in the oral care compositions of certain organic peroxy compounds as teeth whitening/bleaching agents, particularly peroxyamidophthalamides, sulphoperbenzoic acid, monoperoxyphthalic acid, and (per)acetylatedperboric acid with imine quaternary salts as catalysts for the peroxy compounds

Get Free WhatsApp Updates!
Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
22 March 2001
Publication Number
52/2006
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2007-08-09
Renewal Date

Applicants

HINDUSTAN UNILEVER LIMITED
HINDUSTAN LEVER HOUSE, 165-166 BACKBAY RECLAMATION, MUMBAI- 400 020,

Inventors

1. JOINER ANDREW
UNILEVER RESEARCH PORT SUNLIGHT, QUARRY ROAD EAST, BEBINGTON, WIRRAL, MERSEYSIDE, L63 3JW,
2. THORNTHWAITE DAVID WILLIAM
UNILEVER RESEARCH PORT SUNLIGHT, QUARRY ROAD EAST, BEBINGTON, WIRRAL, MERSEYSIDE, L63 3JW,

Specification

FORM-2 THE PATENTS ACT, 1970 (39 OF 1970) COMPLETE SPECIFICATION (See Section 10; rule 13) 1. TITLE OF INVENTION ORAL COMPOSITION WITH AN IMPROVED TEETH WHITENING EFFECT HINDUSTAN LEVER LIMITED, a company incorporated under the Indian Companies Act. 1913 and having its registered office at Hindustan Lever house, 165/166, Backbay Reclamation, Mumbai -400 020, Maharashtra, India The following specification particularly describes the nature of the invention and the manner in which it is to be performed. The present invention related to an oral composition with an improved teeth whitening effect. More particularly, it relates to an oral composition with an improved teeth whitening effect comprising a safe and effective amount of certain organic peroxy compounds and certain catalysts, which are capable of reacting with the organic peroxy compounds to generate more reactive oxygen species. The use of peroxy compounds in oral care compositions has already been proposed in the prior art. Many peroxy compounds have been suggested for whitening/ bleaching human teeth, and representative examples of such peroxy compounds are hydrogen peroxide, urea peroxide, organic peracids such as perphathalic acid, diperoxycarboxylic acids, 1,12- dodecanedioic peroxy acid, peroxy acetic acid and systems comprising a peroxy compound and a peroxy acid precursor which generate peroxy acetic acid in situ, such as sodium perborate and tetraacetylethylene diamine (TAED). The use of peroxy acetic acid is suggested in particular in e.g. EP-A-0545,594 (Colgate), which also sets out the various prior proposals, made in the art for several peroxy compounds as bleaching/whitening agent for human teeth. In our WO-A-96/05802 we have described the use of various organic peroxyacids as teeth whitening agents. We have now found that certain organic peroxy compounds, which will be defined hereinafter, when used together with certain catalysts, defined hereinafter, are much more effective than the organic peroxy compounds above, even in the absence of a peroxy acid precursor (bleach precursor) , producing a teethwhitening effect much more rapidly. These certain organic peroxy compounds are selected from the group consisting of: 1) peroxy amido phthalamides having the structural formula: in which R = hydrogen or C1-C4 alkyl; n = I to 5; and X = C=0 or SO; 2) sulphoperbenzoic acid ("SPB"), 3) monoperoxyphthalic acid ("MPP"), and 4) (per)acetylperoxyboric acid and/or salts thereof. The peroxy amido phthalamides of formula 1) are known per se and have been described in EP-A-325,288 and EP-A-325,289^ A preferred compound of this formula is N-phthalimido hexanoic peroxy acid ("PAP") of formula 1), in which B = H, n = 5 and X = C=0. An example of a compound according to formula 1) wherein X - S02 is saccharin-perhexanoic acid ("saccharin PAP"), as described in EP-A-^85,927. The salts of these peroxyacids are preferably the alkalimetal salts. The salts of sulphoperbenzoic are preferably the alkalimetal salts, particularly preferably the potassium salt ("KSPB"). This peroxyacid has been described in EP-A-124,968 and EP-A-212,913. The salts of monoperoxyphthalic acid are preferably the alkalimetal and alkaline earth metal salts, particularly preferably the magnesium salt. The use of magnesium monoperoxyphthalate in oral care products has been described in US-A-4,670,252. (Per)acetylperoxyboric acid and salts thereof are also known per se from EP-A-212,913. Preferably, the peroxy compound is PAP and/or KSPB. The amount of the peroxy compounds,used in the present invention, may vary from 0.01 to 99 % by weight of the oral composition, preferably from 0.1 to 30 % by weight, particularly preferably from 0.1-5 % by weight. The catalysts, used in the present invention are imine quaternary salts as described in"US-A-5,360, 568 yand US-A-5,3 60,569, which are hereby incorporated by way of Reference. Suitable examples of these imine quaternary salts are of the formula: (formula I) wherein Ri is hydrogen or a Ci-C8 alkyl group, R2 is hydrogen, or a phenyl group or a keto group, R3/ R-i and R5 are hydrogen or -0-R1, whereby R1 is a C1-C4 alkyl group, R6 and R7 are hydrogen or a C\-Ct alkyl group and X is a counterion, stable in the presence of oxidizing agents, comprising Br", BF4", CI", CH3S (H48) (3.6 x 10-2M) with IQ200 (3.6 x 10-3M) % stain removed Time H48 (s.d.) H48 + IQ200 (s.d.) (mins) 0 0 0 0.5 27 (5) 89 (4) 1.0 62 (5) 97 (2) 2.0 80 (6) — Example V Bovine enamel slabs were stained with Stookey type stain and brushed with a conventional toothpaste (RDA = 100), with or without PAP/IQ200 (1 %/0.11 % w/w) in a brushing machine for 2,100 strokes. The increase in L* was measured WE Claims 1. An oral composition with an improved teeth whitening effect, comprising a safe and effective amount of an organic peroxy compound, selected from the group consisting of: 1) peroxy amido phthalamides having the structural formula: in which R = hydrogen or N-(CHR)n-CChH Ci-C< alkyl; n = 1 to 5; and X = C=0 or S02 sulphoperbenzoic acid 3) monoperoxyphthalic acid, and per)acetylperoxyboric acid, and/or salts thereof, characterised in that the composition further comprises an imine quaternary salt of the formula (formula I) wherein Ri is hydrogen or a Ci-Cs alkyl group, R2 is hydrogen, or a phenyl group or a keto group, R3, R4 and R5 are hydrogen or -O-R1, whereby R1 is a C1-C4 alkyl group and X is a counterion, stable in the presence of oxidizing agents, comprising Br"' BF4", CI", CH3SO4~, tosylate , PF6", F , fluorophosphate cations and Ci2_ alkylsulphate cations; and a humectant. 2. A composition according to claim 1, characterised in that the organic peroxy compound is N-phthalimido hexanoic peroxy acid or sulphoperbenzoic acid. 3. A composition according to claim 1 or 2, characterised in that the imine quaternary salt is a compound according to formula (I) wherein R1 is methyl, R2-R6 are all hydrogen and X is tosylate DR. SANCHITA GANGULI OF S. MAJUMDAR & CO. (APPLICANT'S AGENT)

Documents

Application Documents

# Name Date
1 in-pct-2001-00318-mum-form-pct-isa-210(29-08-2003).pdf 2003-08-29
2 in-pct-2001-00318-mum-form-pct-ipea-409(29-08-2003).pdf 2003-08-29
3 in-pct-2001-00318-mum-form 2(granted)-(23-12-2003).pdf 2003-12-23
5 in-pct-2001-00318-mum-claims(granted)-(23-12-2003).pdf 2003-12-23
7 in-pct-2001-00318-mum-cancelled pages(23-12-2003).pdf 2003-12-23
8 in-pct-2001-00318-mum-power of attorney(28-9-1998).pdf 2018-08-08
9 in-pct-2001-00318-mum-form 3(22-3-01).pdf 2018-08-08
10 in-pct-2001-00318-mum-form 1a(23-12-03).pdf 2018-08-08
11 in-pct-2001-00318-mum-form 19(23-6-03).pdf 2018-08-08
12 in-pct-2001-00318-mum-correspondence2(23-3-01).pdf 2018-08-08
13 in-pct-2001-00318-mum-correspondence1(27-11-07).pdf 2018-08-08
14 in-pct-2001-00318-mum-correspondence(ipo)-(17-1-06).pdf 2018-08-08
15 208772-FORM 27-2010.pdf 2024-03-04

ERegister / Renewals

3rd: 12 Sep 2007

From 20/09/2001 - To 20/09/2002

4th: 12 Sep 2007

From 20/09/2002 - To 20/09/2003

5th: 12 Sep 2007

From 20/09/2003 - To 20/09/2004

6th: 12 Sep 2007

From 20/09/2004 - To 20/09/2005

7th: 12 Sep 2007

From 20/09/2005 - To 20/09/2006

8th: 12 Sep 2007

From 20/09/2006 - To 20/09/2007

9th: 12 Sep 2007

From 20/09/2007 - To 20/09/2008

10th: 29 Aug 2008

From 20/09/2008 - To 20/09/2009

11th: 13 Aug 2009

From 20/09/2009 - To 20/09/2010