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“P70 S6 Kinase Inhibitor And Mtor Inhibitor Combination Therapy”
Abstract: The present invention provides a combination therapy comprising the compound 4-[4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine, or a pharmaceutically acceptable salt thereof, and an EGFR inhibitor for use in the treatment of glioblastoma multiforme, adenocarcinomas of the colon, non-small-cell lung cancer, small-cell lung cancer, cisplatin-resistant small-cell lung cancer, ovarian cancer, leukemia, pancreatic cancer, prostate cancer, mammary carcinoma, renal cell carcimoma, multiple myeloma, Kaposis Sarcoma, Hodgkins lymphoma, lymphangioleiomyomatosis, Non-Hodgkins lymphoma or sarcoma.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
04 April 2011
Publication Number
51/2011
Publication Type
INA
Invention Field
PHARMACEUTICALS
Status
Email
Parent Application
Applicants
ELI LILLY AND COMPANY
Lilly Corporate Center Indianapolis Indiana 46285 United States of America
Inventors
1. GEEGANAGE Sandaruwan
Eli Lilly and Company Lilly Corporate Center Indianapolis Indiana 46285 United States of America
2. DONOHO Gregory Paul
Eli Lilly and Company Lilly Corporate Center Indianapolis Indiana 46285 United States of America
Specification
PLEASE SEE THE SPECIFICATION ATTACHED
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 653 - MUMNP - 2011 FORM 26 02-09-2009.pdf | 2009-09-02 |
| 1 | 653 - MUMNP - 2011 PCT DOCUMENTS.pdf | 2023-10-25 |
| 2 | 653 - MUMNP - 2011 ASSIGNMENT - 24-03-2011.pdf | 2011-03-24 |
| 2 | 653-MUMNP-2011-CLAIMS(MARKED COPY)-(11-4-2011).pdf | 2018-08-11 |
| 3 | 653-MUMNP-2011-CORRESPONDENCE(11-4-2011).pdf | 2018-08-11 |
| 3 | 653 - MUMNP - 2011 FORM 5 - 04-04-2011.pdf | 2011-04-04 |
| 4 | 653-MUMNP-2011-CORRESPONDENCE(16-6-2011).pdf | 2018-08-11 |
| 4 | 653 - MUMNP - 2011 FORM 3 - 04-04-2011.pdf | 2011-04-04 |
| 5 | 653-MUMNP-2011-CORRESPONDENCE(7-4-2011).pdf | 2018-08-11 |
| 5 | 653 - MUMNP - 2011 FORM 2 04-04-2011.pdf | 2011-04-04 |
| 6 | 653-MUMNP-2011-CORRESPONDENCE(9-8-2011).pdf | 2018-08-11 |
| 6 | 653 - MUMNP - 2011 FORM 1 - 04-04-2011.pdf | 2011-04-04 |
| 7 | 653-MUMNP-2011-CORRESPONDENCE(IPO)-(24-6-2014).pdf | 2018-08-11 |
| 7 | 653 - MUMNP - 2011 CORRESPONDENCE - 04-04-2011.pdf | 2011-04-04 |
| 8 | 653-MUMNP-2011-CORRRESPONDENCE(1-8-2012).pdf | 2018-08-11 |
| 8 | 653 - MUMNP - 2011 CORRESPONDENCE - 07-04-2011.pdf | 2011-04-07 |
| 9 | 653 - MUMNP - 2011 FORM 13 - 11-04-2011.pdf | 2011-04-11 |
| 9 | 653-MUMNP-2011-FORM 1(1-8-2012).pdf | 2018-08-11 |
| 10 | 653 - MUMNP - 2011 FORM 13 - 01-08-2011.pdf | 2011-08-01 |
| 10 | 653-MUMNP-2011-FORM 13(1-8-2012).pdf | 2018-08-11 |
| 11 | 653-mumnp-2011-form 13(11-4-2011).pdf | 2018-08-11 |
| 11 | Form-5.pdf | 2018-08-11 |
| 12 | 653-MUMNP-2011-FORM 18(7-4-2011).pdf | 2018-08-11 |
| 12 | Form-3.pdf | 2018-08-11 |
| 13 | 653-MUMNP-2011-FORM 3(9-8-2011).pdf | 2018-08-11 |
| 13 | Form-1.pdf | 2018-08-11 |
| 14 | 653-MUMNP-2011-FORM PCT-IB-373(16-6-2011).pdf | 2018-08-11 |
| 14 | 653-MUMNP-2011_EXAMREPORT.pdf | 2018-08-11 |
| 15 | 653-MUMNP-2011-FORM PCT-ISA-237(16-6-2011).pdf | 2018-08-11 |
| 16 | 653-MUMNP-2011-FORM PCT-IB-373(16-6-2011).pdf | 2018-08-11 |
| 16 | 653-MUMNP-2011_EXAMREPORT.pdf | 2018-08-11 |
| 17 | Form-1.pdf | 2018-08-11 |
| 17 | 653-MUMNP-2011-FORM 3(9-8-2011).pdf | 2018-08-11 |
| 18 | Form-3.pdf | 2018-08-11 |
| 18 | 653-MUMNP-2011-FORM 18(7-4-2011).pdf | 2018-08-11 |
| 19 | 653-mumnp-2011-form 13(11-4-2011).pdf | 2018-08-11 |
| 19 | Form-5.pdf | 2018-08-11 |
| 20 | 653 - MUMNP - 2011 FORM 13 - 01-08-2011.pdf | 2011-08-01 |
| 20 | 653-MUMNP-2011-FORM 13(1-8-2012).pdf | 2018-08-11 |
| 21 | 653 - MUMNP - 2011 FORM 13 - 11-04-2011.pdf | 2011-04-11 |
| 21 | 653-MUMNP-2011-FORM 1(1-8-2012).pdf | 2018-08-11 |
| 22 | 653 - MUMNP - 2011 CORRESPONDENCE - 07-04-2011.pdf | 2011-04-07 |
| 22 | 653-MUMNP-2011-CORRRESPONDENCE(1-8-2012).pdf | 2018-08-11 |
| 23 | 653 - MUMNP - 2011 CORRESPONDENCE - 04-04-2011.pdf | 2011-04-04 |
| 23 | 653-MUMNP-2011-CORRESPONDENCE(IPO)-(24-6-2014).pdf | 2018-08-11 |
| 24 | 653 - MUMNP - 2011 FORM 1 - 04-04-2011.pdf | 2011-04-04 |
| 24 | 653-MUMNP-2011-CORRESPONDENCE(9-8-2011).pdf | 2018-08-11 |
| 25 | 653-MUMNP-2011-CORRESPONDENCE(7-4-2011).pdf | 2018-08-11 |
| 25 | 653 - MUMNP - 2011 FORM 2 04-04-2011.pdf | 2011-04-04 |
| 26 | 653-MUMNP-2011-CORRESPONDENCE(16-6-2011).pdf | 2018-08-11 |
| 26 | 653 - MUMNP - 2011 FORM 3 - 04-04-2011.pdf | 2011-04-04 |
| 27 | 653-MUMNP-2011-CORRESPONDENCE(11-4-2011).pdf | 2018-08-11 |
| 27 | 653 - MUMNP - 2011 FORM 5 - 04-04-2011.pdf | 2011-04-04 |
| 28 | 653-MUMNP-2011-CLAIMS(MARKED COPY)-(11-4-2011).pdf | 2018-08-11 |
| 28 | 653 - MUMNP - 2011 ASSIGNMENT - 24-03-2011.pdf | 2011-03-24 |
| 29 | 653 - MUMNP - 2011 PCT DOCUMENTS.pdf | 2023-10-25 |
| 29 | 653 - MUMNP - 2011 FORM 26 02-09-2009.pdf | 2009-09-02 |