Peroxisome Proliferator Activated Receptor Alpha Agonist Compounds

Abstract: The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C0-2-alkyl, heteroaryl-C0-2-alkyl, C3-C6 cycloalkylaryl-C0-2-alkyl or phenyl. W is O or S. R2 is H or a substituted or unsubstituted group selected from C1-C6 alkyl, C3-C6 cycloalkyl and heteroaryl. X is a C2-C5 alkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S. Y is C, O, S, NH or a single bond. Furthermore, E is (CH2)nCOOH, wherein n is 0, 1, 2 or 3, or C(R3)(R4)A, wherein A is an acidic functional group such as carboxyl, carboxamide substituted or unsubstituted sulfonamide, or substituted or unsubstituted tetrazole. R3 is H, saturated or unsaturated C1-C5 alkyl, C1-C5 alkoxy. Additionally, R4 is H, halo, a substituted or unsubstituted group selected from C1-C5 alkyl, C1-C5 alkoxy, C3-C6 cycloalkyl, arylC0-C4alkyl and phenyl, or R3 and R4 are combined to form a C3-C4 cycloalkyl.

Patent Information

Application #

Filing Date

07 June 2007

Publication Number

32/2007

Publication Type

INA

Invention Field

PHARMACEUTICALS

Status

Email

Parent Application

Applicants

ELI LILLY AND COMPANY

LILLY CORPORATE CENTER, DC 1104, INDIANAPOLIS, IN

Inventors

1. MANTLO, NATHAN, BRYAN

7325 EAST 800 NORTH, BROWNSBURG, IN 46112

2. COLLADO CANO, IVAN

LILLY S.A., AVDA. INDUSTRIA, 30, E-28108 ALCOBENDAS-MADRID

3. DOMINIANNI, SAMUEL, JAMES

7873 CLEARWATER COVE, DRIVE, INDIANAPOLIS, IN 46240

4. ETGEN, GARRET, JAY, JUNIOR

13763 ADIOS PASS, CARMEL, IN 46032

5. GARCIA-PAREDES, CRISTINA

LILLY S.A., AVDA. INDUSTRIA, 30, E-28108 ALCOBENDAS-MADRID

6. JOHNSTON, RICHARD, DUANE

3712 FOREST LANE, GREENFIELD, IN 46140

7. LETOURNEAU, MICHAEL, EDWARD

6024 MCCLELLAN COURT, INDIANAPOLIS, IN 46254

8. MARTINELLI, MICHAEL, JOHN

1935 MULSANNE DRIVE, ZIONSVILLE, IN 46077

9. MAYHUGH, DANIEL, RAY

9681 TROON COURT, CARMEL, IN 46032

10. SAEED, ASHRAF

1500 WORCESTER ROAD, APARTMENT 428, FRAMINGHAM, MA 01702

11. THOMPSON, RICHARD, CRAIG

763 NORTH 900 WEST, FRANKFORT, IN 46041

12. WANG, XIADONG

14066 HONEY TREE DRIVE, CARMEL, IN 46032

13. COFFEY, DAVID, SCOTT

6246 TENNISON WAY, INDIANAPOLIS, IN 46236

14. SCHMID, CHRISTOPHER, RANDALL

6235 CENTRAL AVENUE, INDIANAPOLIS, IN 46220

15. VICENZI, JEFFREY, THOMAS

49 TIMBER LANE, BROWNSBURG, IN 46112

16. XU, YANPING

13832 BARNETT PLACE, FISHERS, IN 46038

Specification

The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C0-2-alkyl, heteroaryl-C0-2-alkyl, C3-C6 cycloalkylaryl-C0-2-alkyl or phenyl. W is O or S. R2 is H or a substituted or unsubstituted group selected from C1-C6 alkyl, C3-C6 cycloalkyl and heteroaryl. X is a C2-C5 alkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S. Y is C, O, S, NH or a single bond. Furthermore, E is (CH2)nCOOH, wherein n is 0, 1, 2 or 3, or C(R3)(R4)A, wherein A is an acidic functional group such as carboxyl, carboxamide substituted or unsubstituted sulfonamide, or substituted or unsubstituted tetrazole. R3 is H, saturated or unsaturated C1-C5 alkyl, C1-C5 alkoxy. Additionally, R4 is H, halo, a substituted or unsubstituted group selected from C1-C5 alkyl, C1-C5 alkoxy, C3-C6 cycloalkyl, arylC0-C4alkyl and phenyl, or R3 and R4 are combined to form a C3-C4 cycloalkyl.

Documents

Application Documents

#	Name	Date
1	2065-KOLNP-2007-ABSTRACT-1.pdf	2018-09-20
1	abstract-02065-kolnp-2007.jpg	2011-10-07
2	02065-kolnp-2007-pct request form.pdf	2011-10-07
2	2065-KOLNP-2007-CLAIMS-1.pdf	2018-09-20
3	2065-KOLNP-2007-DESCRIPTION (COMPLETE)-1.pdf	2018-09-20
3	02065-kolnp-2007-international search report.pdf	2011-10-07
4	2065-KOLNP-2007-DESCRIPTION (COMPLETE)-2.pdf	2018-09-20
4	02065-kolnp-2007-international publication.pdf	2011-10-07
5	2065-KOLNP-2007-DESCRIPTION (COMPLETE)-3.pdf	2018-09-20
5	02065-kolnp-2007-form 5.pdf	2011-10-07
6	2065-KOLNP-2007-DESCRIPTION (COMPLETE)-4.pdf	2018-09-20
6	02065-kolnp-2007-form 3.pdf	2011-10-07
7	2065-KOLNP-2007-ABSTRACT.pdf	2017-03-10
7	02065-kolnp-2007-form 3 1.1.pdf	2011-10-07
8	2065-KOLNP-2007-CLAIMS.pdf	2017-03-10
8	02065-kolnp-2007-form 2.pdf	2011-10-07
9	02065-kolnp-2007-form 18.pdf	2011-10-07
9	2065-KOLNP-2007-ABANDONED LETTER.pdf	2017-01-19
10	02065-kolnp-2007-form 1.pdf	2011-10-07
10	2065-KOLNP-2007-FIRST EXAMINATION REPORT.pdf	2017-01-19
11	2065-KOLNP-2007-ABANDONED LETTER.pdf	2016-10-05
12	02065-kolnp-2007-correspondence others.pdf	2011-10-07
12	2065-KOLNP-2007_EXAMREPORT.pdf	2016-06-30
13	02065-kolnp-2007-abstract.pdf	2011-10-07
13	02065-kolnp-2007-correspondence others 1.1.pdf	2011-10-07
14	02065-kolnp-2007-claims.pdf	2011-10-07
15	02065-kolnp-2007-abstract.pdf	2011-10-07
15	02065-kolnp-2007-correspondence others 1.1.pdf	2011-10-07
16	02065-kolnp-2007-correspondence others.pdf	2011-10-07
16	2065-KOLNP-2007_EXAMREPORT.pdf	2016-06-30
17	2065-KOLNP-2007-ABANDONED LETTER.pdf	2016-10-05
18	2065-KOLNP-2007-FIRST EXAMINATION REPORT.pdf	2017-01-19
18	02065-kolnp-2007-form 1.pdf	2011-10-07
19	2065-KOLNP-2007-ABANDONED LETTER.pdf	2017-01-19
19	02065-kolnp-2007-form 18.pdf	2011-10-07
20	02065-kolnp-2007-form 2.pdf	2011-10-07
20	2065-KOLNP-2007-CLAIMS.pdf	2017-03-10
21	02065-kolnp-2007-form 3 1.1.pdf	2011-10-07
21	2065-KOLNP-2007-ABSTRACT.pdf	2017-03-10
22	02065-kolnp-2007-form 3.pdf	2011-10-07
22	2065-KOLNP-2007-DESCRIPTION (COMPLETE)-4.pdf	2018-09-20
23	02065-kolnp-2007-form 5.pdf	2011-10-07
23	2065-KOLNP-2007-DESCRIPTION (COMPLETE)-3.pdf	2018-09-20
24	02065-kolnp-2007-international publication.pdf	2011-10-07
24	2065-KOLNP-2007-DESCRIPTION (COMPLETE)-2.pdf	2018-09-20
25	02065-kolnp-2007-international search report.pdf	2011-10-07
25	2065-KOLNP-2007-DESCRIPTION (COMPLETE)-1.pdf	2018-09-20
26	2065-KOLNP-2007-CLAIMS-1.pdf	2018-09-20
26	02065-kolnp-2007-pct request form.pdf	2011-10-07
27	abstract-02065-kolnp-2007.jpg	2011-10-07
27	2065-KOLNP-2007-ABSTRACT-1.pdf	2018-09-20