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Peroxisome Proliferator Activated Receptor Alpha Agonist Compounds.
Abstract: The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C1-C8 alkyl, aryl-CO-2-alkyl, heteroaryl-CO-2-alkyl, C3-C6 cycloalkylaryl-CO-2-alkyl or phenyl. W is O or S. R2 is H or a substituted or unsubstituted group selected from C1-C6 alkyl, C3-C6 cycloalkyl and heteroaryl. X is a C2-C5 alkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S. Y is C, O, S, NH or a single bond. Furthermore, E is (CH2)nCOOH, wherein n is 0, 1, 2 or 3, or C(R3)(R4)A, wherein A is an acidic functional group such as carboxyl, carboxamide substituted or unsubstituted sulfonamide, or substituted or unsubstituted tetrazole. R3 is H, saturated or unsaturated C1-C5 alkyl, C1-C5 alkoxy. Additionally, R4 is H, halo, a substituted or unsubstituted group selected from C1-C5 alkyl, C1-C5 alkoxy, C3-C6 cycloalkyl, arylCO-C4alkyl and phenyl, or R3 and R4 are combined to form a C3-C4 cycloalkyl.
Notices, Deadlines & Correspondence
Patent Information
Applicants
ELI LILLY AND COMPANY
Inventors
1. 1] MANTLO, NATHAN, BRYAN
2. 2] COLLADO CANO, IVAN
3. 3] DOMINIANNI, SAMUEL, JAMES
4. 4] ETGEN, GARRET, JAY, JUNIOR
5. 5] GARCIA-PAREDES, CRISTINA
6. 6] JOHNSTON, RICHARD, DUANE
7. 7] LETOURNEAU, MICHAEL, EDWARD
8. 8] MARTINELLI, MICHAEL, JOHN
9. 9] MAYHUGH, DANIEL, RAY
10. 10] SAEED, ASHRAF
11. 11] THOMPSON, RICHARD, CRAIG
12. 12] WANG, XIADONG
13. 13] COFFEY, DAVID, SCOTT
14. 14] SCHMID, CHRISTOPHER, RANDALL
15. 15] VICENZI, JEFFREY, THOMAS
16. 16] XU, YANPING
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 278-KOLNP-2003-24-01-2023-ALL DOCUMENTS.pdf | 2023-01-24 |
| 1 | 278-kolnp-2003-granted-translated copy of priority document.pdf | 2011-10-06 |
| 2 | 278-KOLNP-2003-CORRESPONDENCE-1.pdf | 2018-09-20 |
| 2 | 278-kolnp-2003-granted-specification.pdf | 2011-10-06 |
| 3 | 278-kolnp-2003-granted-reply to examination report.pdf | 2011-10-06 |
| 3 | 278-kolnp-2003-granted-abstract.pdf | 2011-10-06 |
| 4 | 278-kolnp-2003-granted-letter patent.pdf | 2011-10-06 |
| 4 | 278-kolnp-2003-granted-claims.pdf | 2011-10-06 |
| 5 | 278-kolnp-2003-granted-gpa.pdf | 2011-10-06 |
| 5 | 278-kolnp-2003-granted-correspondence.pdf | 2011-10-06 |
| 6 | 278-kolnp-2003-granted-form 5.pdf | 2011-10-06 |
| 6 | 278-kolnp-2003-granted-description (complete).pdf | 2011-10-06 |
| 7 | 278-kolnp-2003-granted-form 3.pdf | 2011-10-06 |
| 7 | 278-kolnp-2003-granted-form 1.pdf | 2011-10-06 |
| 8 | 278-kolnp-2003-granted-form 13.pdf | 2011-10-06 |
| 8 | 278-kolnp-2003-granted-form 26.pdf | 2011-10-06 |
| 9 | 278-kolnp-2003-granted-form 2.pdf | 2011-10-06 |
| 10 | 278-kolnp-2003-granted-form 26.pdf | 2011-10-06 |
| 10 | 278-kolnp-2003-granted-form 13.pdf | 2011-10-06 |
| 11 | 278-kolnp-2003-granted-form 3.pdf | 2011-10-06 |
| 11 | 278-kolnp-2003-granted-form 1.pdf | 2011-10-06 |
| 12 | 278-kolnp-2003-granted-form 5.pdf | 2011-10-06 |
| 12 | 278-kolnp-2003-granted-description (complete).pdf | 2011-10-06 |
| 13 | 278-kolnp-2003-granted-gpa.pdf | 2011-10-06 |
| 13 | 278-kolnp-2003-granted-correspondence.pdf | 2011-10-06 |
| 14 | 278-kolnp-2003-granted-letter patent.pdf | 2011-10-06 |
| 14 | 278-kolnp-2003-granted-claims.pdf | 2011-10-06 |
| 15 | 278-kolnp-2003-granted-reply to examination report.pdf | 2011-10-06 |
| 15 | 278-kolnp-2003-granted-abstract.pdf | 2011-10-06 |
| 16 | 278-kolnp-2003-granted-specification.pdf | 2011-10-06 |
| 16 | 278-KOLNP-2003-CORRESPONDENCE-1.pdf | 2018-09-20 |
| 17 | 278-kolnp-2003-granted-translated copy of priority document.pdf | 2011-10-06 |
| 17 | 278-KOLNP-2003-24-01-2023-ALL DOCUMENTS.pdf | 2023-01-24 |