DESC:FIELD OF THE INVENTION:

The present invention relates to synergistic pesticidal composition comprising A) Methoxyfenozide B) at least one insecticide selected from Indoxacarb and Emamectin Benzoate C) at least one more insecticide selected from Bifenthrin, Cypermethrin, Deltamethrin, Fenpropathrin, Lambda cyhalotrhin, Acephate, Chlorpyrifos, Profenofos, Quinalphos, Triazophos, Acetamiprid, Clothianidin, Imidacloprid, Thiamethoxam, Novaluron, Lufenuron, Chlorfluazuron, Pyriproxyfen, Chlorantraniliprole, Cyantraniliprole, Flubendiamide, Abamectin, Spinetoram, Spinosad, Chlorfenapyr, Diafenthiuron, Fipronil, Pyridalyl and Tolfenpyrad with one or more inactive excipients. The present invention also relates to process for preparing the said composition and its use in crops.

BACKGROUND OF THE INVENTION

Pesticides are substances meant for attracting, seducing, and then destroying any pest. They are a class of biocide. The most common use of pesticides is as plant protection products (also known as crop protection products), which in general protect plants from damaging influences such as weeds, fungi, or insects. In some cases, pesticidal active ingredients have been shown to be more effective in combination than when applied individually and this is referred to as "synergism." Synergism is an interaction of two or more factors such that the effect when combined is greater than the predicted effect based on the response of each factor applied separately."

The effectiveness of pesticide depends inter alia on the nature of the pesticide employed, its application rate, the preparation, the respective to the harmful plants, the climatic and soil conditions and the like. Another criterion is the duration of the action, or the degradation rate of the pesticide. Considerations include if appropriate, changes in the sensitivity of harmful plants to an active compound which may occur on prolonged use or geographically limited. Such changes manifest themselves as more or less pronounced loss in activity and can be only partially offset by higher pesticide application rates.

Because of the large number of possible influencing factors, there is virtually no individual active compound which, combined the desired properties for different requirements, in particular with regard to the harmful plants and the climatic zones in itself. Then there is the constant need to achieve the effect with ever lower pesticide application rates. A lower application rate reduces not only the required for the application amount of a pesticide, but usually reduces the amount of formulation auxiliaries required. Both reduce the economic expense and improve the ecological compatibility of the pesticide treatment.

Methoxyfenozide was first disclosed in US 5530028. The patent claimed an insecticidal compound having the formula N-(2-Ra -3-Rb -4-Rh -benzoyl)-N'-(2-Rc -3-Rd -4-Re -5-Rf -benzoyl)-N'-Rg -hydrazine wherein Ra is a halo or lower alkyl; Rb is lower alkoxy; Rc is selected from hydrogen, halo and lower alkyl; Rd, Re and Rf are each independently selected from hydrogen, bromo, chloro, fluoro and lower alkyl; Rg is a (C4 -C6)alkyl; Rh is hydrogen or lower alkyl. Chemical structure of Methoxyfenozide is as provided below;

Methoxyfenozide is available as Intrepid (Dow AgroSci.); Runner (Bayer CropSci.); Prodigy (Dow AgroSci.).

Methoxyfenozide is a chemical compound from the group of diacylhydrazines. Methoxyfenozide acts as ecdysone - agonist that causes a premature molting of the insect. The effect depends highly selective butterflies; the insecticide is used against pests such as the codling moth, the monovalent and crossed grape, the European corn borer or the horse chestnut leaf mine.

Indian patent application 1318/CHENP/2014 describes arthropod pest control composition according to the present invention comprises an amide compound represented by formula (1) at least one insect growth regulator compound selected from group (A) and at least one planthopper control compound selected from group (B) and has an excellent controlling effect on arthropod pests. Group (A): a group consisting of methoxyfenozide, chromafenozide and tebufenozide. Group (B): a group consisting of clothianidin, nitenpyram, buprofezin and ethiprole.

Indian patent application 7932/CHENP/2013 discloses arthropod pest control composition comprising a cyanamide compound represented by the formula (1): one or more insect growth regulating compounds selected from Group (A), and one or more sheath blight control compounds selected from Group (B): Group (A): a group consisting of methoxyfenozide, chromafenozide, and tebufenozide, and Group (B): a group consisting of flutolanil, pencycuron, N- [2-(1,3-dimethylbutyl)phenyl]-5-fluoro-l,3-dimethyl-lH- pyrazole-4-carboxamide, furametpyr, and validamycin A.

Indian patent application 1006/MUM/2003 describes compositions comprising mixtures of N²-[1,1-dimethyl-2-(methylsuphonyl)-ethyl]-3-iodo-N¹-{2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-phenyl}phthalamide of the formula (I) and at least one of the compound listed below: triflumuron, flufenoxuron, methoxyfenozide, tebufenozide, thiacloprid, thiamethoxam, dinotefuran, clothianidin, deltamethrin, ethiprole, fipronil, indoxacarb, emamectin-benzoate, abamectin, spinosad.

CN 103461333 A discloses an insecticide composition containing flubendiamide and methoxyfenozide with a weight ratio of 50: 1 to 1:50, 25: 1 to 1:25, 10: 1 to 1:10 and 5: 1 to 1: 5.

CN 104186474 A discloses an insecticide composition containing chlorine chlorfenapyr and methoxyfenozide and weight percentage of the sum of the pesticidal composition of 2-80%.

CN 103355297 A discloses an insecticide composition containing methoxyfenozide and flubendiamide with ratio 1~50: 50~1.

CN 101268783 A discloses an insecticide composition containing Chlorpyrifos and acephate with Chlorpyrifos: 10 to 45%, acephate: 1 to 10% efficiency Additives: from 0.05% to 10%, Emulsifier: 1 to 20%, and the balance of the solvent; starting material was 100% by weight.

WO 2012170836 A1 discloses insecticide composition containing indoxacarb and deltamethrin with the ratio of indoxacarb to deltamethrin is between 1 to 10 and 10 to 1.

Indian patent application 14/MUMNP/2004 describes insecticidal composition comprising gamma-cyhalothrin and one or more further active ingredients having insecticidal, nematicidal or acaricidal activity wherein the further active ingredient is one or more of thiamethoxam, Abamectin, spinosad, chlorpyrifos, chlorpyrifos-methyl, profenofos, lufenuron, indoxacarb, lambda-cyhalothrin, pymetrozine, methidathion, imidacloprid, acetamiprid, thiacloprid, fipronil, methoxyfenozide, chlorfenapyr, pyridaben, novaluron, pyridalyl and piperonyl butoxide, an insecticidally inert carrier or diluent and, optionally, one or more surface active agents, wherein the ingredients gamma-cyhalothrin and second insecticide are present in the ratio 1:100 to 100:1 weight/weight.
However still there is a need for a pesticidal composition which overcomes some of the existing problems and can be prepared easily without much complex manufacturing process.

Inventors of the present invention have surprisingly found that the pesticidal composition comprising synergistically effective amounts of A) Methoxyfenozide B) insecticide selected from Indoxacarb and Emamectin Benzoate C) at least one more insecticide selected from Bifenthrin, Cypermethrin, Deltamethrin, Fenpropathrin, Lambda cyhalotrhin, Acephate, Chlorpyrifos, Profenofos, Quinalphos, Triazophos, Acetamiprid, Clothianidin, Imidacloprid, Thiamethoxam, Novaluron, Lufenuron, Chlorfluazuron, Pyriproxyfen, Chlorantraniliprole, Cyantraniliprole, Flubendiamide, Abamectin, Spinetoram, Spinosad, Chlorfenapyr, Diafenthiuron, Fipronil, Pyridalyl and Tolfenpyrad with one or more inactive excipients described herein in can provide solution to the above mentioned problems.

SUMMARY OF THE INVENTION

It is an aspect of the present invention is to provide, with a view to effective resistance management and effective control of phytopathogenic harmful pests, at application rates which are as low as possible, compositions which, at a reduced total amount of active compounds applied, have improved activity against the harmful pests and a broadened activity spectrum, in particular for certain indications.

We have accordingly found that this object is achieved by the present pesticidal compositions, defined herein, comprising A) Methoxyfenozide B) at least one insecticide selected from Indoxacarb and Emamectin Benzoate C) at least one more insecticide selected from Bifenthrin, Cypermethrin, Deltamethrin, Fenpropathrin, Lambda cyhalotrhin, Acephate, Chlorpyrifos, Profenofos, Quinalphos, Triazophos, Acetamiprid, Clothianidin, Imidacloprid, Thiamethoxam, Novaluron, Lufenuron, Chlorfluazuron, Pyriproxyfen, Chlorantraniliprole, Cyantraniliprole, Flubendiamide, Abamectin, Spinetoram, Spinosad, Chlorfenapyr, Diafenthiuron, Fipronil, Pyridalyl and Tolfenpyrad.

Accordingly, in a main aspect of the present invention provides a pesticidal composition comprising A) Methoxyfenozide B) at least one insecticide selected from Indoxacarb and Emamectin Benzoate C) at least one more insecticide selected from Bifenthrin, Cypermethrin, Deltamethrin, Fenpropathrin, Lambda cyhalotrhin, Acephate, Chlorpyrifos, Profenofos, Quinalphos, Triazophos, Acetamiprid, Clothianidin, Imidacloprid, Thiamethoxam, Novaluron, Lufenuron, Chlorfluazuron, Pyriproxyfen, Chlorantraniliprole, Cyantraniliprole, Flubendiamide, Abamectin, Spinetoram, Spinosad, Chlorfenapyr, Diafenthiuron, Fipronil, Pyridalyl and Tolfenpyrad with one or more inactive excipient.

Accordingly, in a second aspect, the present invention provides a method of preparing the pesticidal composition comprising A) Methoxyfenozide B) insecticide selected from Indoxacarb and Emamectin Benzoate C) at least one more insecticide selected from Bifenthrin, Cypermethrin, Deltamethrin, Fenpropathrin, Lambda cyhalotrhin, Acephate, Chlorpyrifos, Profenofos, Quinalphos, Triazophos, Acetamiprid, Clothianidin, Imidacloprid, Thiamethoxam, Novaluron, Lufenuron, Chlorfluazuron, Pyriproxyfen, Chlorantraniliprole, Cyantraniliprole, Flubendiamide, Abamectin, Spinetoram, Spinosad, Chlorfenapyr, Diafenthiuron, Fipronil, Pyridalyl and Tolfenpyrad with one or more inactive excipients.

Accordingly, in a third aspect, the present invention provides a method of protecting a plant propagation material, a plant, parts of a plant and/or plant organs that grow at a later point in time against pathogenic damage or pest damage by applying to the plant propagation material a pesticidal composition defined in the first aspect.

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides solution to all the problems mentioned above by providing the pesticidal composition.

The present invention provides a pesticidal composition comprising A) Methoxyfenozide B) insecticide selected from Indoxacarb and Emamectin Benzoate C) at least one more insecticide selected from Bifenthrin, Cypermethrin, Deltamethrin, Fenpropathrin, Lambda cyhalotrhin, Acephate, Chlorpyrifos, Profenofos, Quinalphos, Triazophos, Acetamiprid, Clothianidin, Imidacloprid, Thiamethoxam, Novaluron, Lufenuron, Chlorfluazuron, Pyriproxyfen, Chlorantraniliprole, Cyantraniliprole, Flubendiamide, Abamectin, Spinetoram, Spinosad, Chlorfenapyr, Diafenthiuron, Fipronil, Pyridalyl and Tolfenpyrad with one or more inactive excipients.

"Effective amounts” as mentioned herein means that amount which, when applied treatment of crops, is sufficient to effect such treatment.

The term “formulation” and “composition” as used herein conveys the same meaning and can be used interchangeably.

The formulation or composition of the present invention can be in various physical forms, for example in the form of a dustable powder (DP), a gel, a wettable powder (WP), a granule (GR) (such as an emulsifiable granule (EG) or more particularly a water-dispersible granule (WG)), a water-dispersible tablet (WT), an emulsifiable concentrate (EC), a micro- emulsifiable concentrate, an oil-in-water emulsion (EW), an oil flowable (a spreading oil (SO)), an aqueous dispersion ( aqueous suspension concentrate (SC)), an oily dispersion (OD), a suspo-emulsion (SE), a capsule suspension (CS), a soluble liquid, a water-soluble concentrate (with water or a water-miscible organic solvent as carrier.

One or more of the active ingredients is encapsulated for various purposes, such as to increase the residual biological activity, or to reduce the acute toxicity, or to obtain a physical or chemically stable water-based formulation. The purpose determines whether the “free” active ingredient and the “release rate” are relevant properties of a specific product.

As per one embodiment, the synergistic pesticidal composition comprises A) Methoxyfenozide B) at least one insecticide selected from Indoxacarb and Emamectin Benzoate C) at least one more insecticide selected from Bifenthrin, Cypermethrin, Deltamethrin, Fenpropathrin, Lambda cyhalotrhin, Acephate, Chlorpyrifos, Profenofos, Quinalphos, Triazophos, Acetamiprid, Clothianidin, Imidacloprid, Thiamethoxam, Novaluron, Lufenuron, Chlorfluazuron, Pyriproxyfen, Chlorantraniliprole, Cyantraniliprole, Flubendiamide, Abamectin, Spinetoram, Spinosad, Chlorfenapyr, Diafenthiuron, Fipronil, Pyridalyl and Tolfenpyrad with one or more inactive excipients wherein active ingredients are present in concentration as described below;

Compound A Compound B Compound C

Active ingredients Methoxyfenozide



























Indoxacarb
Emamectin Benzoate


























Bifenthrin
Cypermethrin
Deltamethrin
Fenpropathrin
Lambda cyhalotrhin
Acephate
Chlorpyrifos
Profenofos
Quinalphos
Triazophos
Acetamiprid
Clothianidin
Imidacloprid
Thiamethoxam
Novaluron
Lufenuron
Chlorfluazuron
Pyriproxyfen
Chlorantraniliprole
Cyantraniliprole
Flubendiamide
Abamectin
Spinetoram
Spinosad
Chlorfenapyr
Diafenthiuron
Fipronil
Pyridalyl
Tolfenpyrad
Concentration 0.1-40% 0.1-20% 0.1-40%

In another embodiment of the present invention the pesticidal composition comprising A) Methoxyfenozide B) insecticide selected from Indoxacarb and Emamectin Benzoate C) at least one more insecticide selected from Bifenthrin, Cypermethrin, Deltamethrin, Fenpropathrin, Lambda cyhalotrhin, Acephate, Chlorpyrifos, Profenofos, Quinalphos, Triazophos, Acetamiprid, Clothianidin, Imidacloprid, Thiamethoxam, Novaluron, Lufenuron, Chlorfluazuron, Pyriproxyfen, Chlorantraniliprole, Cyantraniliprole, Flubendiamide, Abamectin, Spinetoram, Spinosad, Chlorfenapyr, Diafenthiuron, Fipronil, Pyridalyl and Tolfenpyrad with one or more inactive excipients effective for control of Insect-pests in Cotton (Gossypium spp.), Jute (Corchorus oliotorus), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Ragi (Eleusine coracana), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum) , Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus) , Mustard (Brassica juncea), Rape seed (Brassica napus), Linseed (Linum usitatissimum), Sesame (Sesamum indicum), Castor (Ricinus communis), Green gram (Vigna radiate), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa subsp rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Litchi (Litchi chinensis), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum) , Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum), Ajwain (Trachyspermum ammi), Psyllium (Plantago ovate), Black Pepper (Piper nigrum), Stevia (Stevia rebaudiana), Safed musli (Chlorophytum tuberosum), Drum stick (Moringa oleifera), Coconut (Coco nucifera), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold ( Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera ( Gerbera jamesonii), Carnation (Dianthus caryophyllus).

In one embodiment of the present invention, the pesticidal composition of present invention controls pests and insects listed below;

Insects from the order of the Lepidoptera, for example Agrotis ypsilon, Alabama argillacea, Anticarsia gemmatalis, Cacoecia murinana, Capua reticulana, Chilo partellus, Chilo suppressalis, Choristoneura fumiferana, Choristoneura occidentalis, Cirphis unipuncta, Cnaphalocrocis medinalis, Cydia pomonella, Diatraea saccharalis, Dendrolimus pini, Diaphania nitidalis, Earias vittella, Earias insulana, Elasmopalpus lignosellus, Eupoecilia ambiguella, Evetria bou-liana, Exelastis atomosa, Feltia subterranea, Galleria mellonella, Grapholitha funebrana, Helicoverpa armigera, Helicoverpa virescens, Helicoverpa zea, Hellula undalis, Hibernia defoliaria, Hyphantria cunea, Hyponomeuta malinellus, Keiferia lycopersicella, Laphygma exigua, Leucinodes orbonalis, Leucoptera coffeella, Leucoptera scitella, Lithocol-letis blancardella, Lobesia botrana, Loxostege sticticalis, Lymantria dispar, Lymantria monacha, Lyonetia clerkella, Malacosoma neustria, Mamestra brassicae, Marasmia pantalis, Maruca vitrata, Maruca testulalis, Mythimna separata, Orgyia pseu-dotsugata, Ostrinia nubilalis, Panolis flammea, Pectinophora gossypiella, Peridroma saucia, Phalera bucephala, Phthorimaea operculella, Phyllocnistis citrella, Pieris bras-sicae, Plathypena scabra, Plutella xylostella, Pseudoplusia includens, Rhyacionia frus-trana, Scirpophaga incertulas, Scirpophaga innotata, Scrobipalpula absoluta, Sesamia inferens, Sitotroga cerealella, Sparganothis pilleriana, Spilosoma obliqua, Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Thaumatopoea pityocampa, Tortrix viridana, Trichoplusia ni, Tuta absolutaand Zeiraphera Canadensis.

Beetles (Coleoptera), for example Adoretus bicolor, Agrilus sinuatus, Agriotes lineatus, Agriotes obscu-rus, Amphimallus solstitialis, Anisandrus dispar, Anthonomus grandis, Anthonomus pomorum, Anomala benghalensis, Aphthona euphoridae, Apogonia aerea, Athous haemorrhoidalis, Atomaria linearis, Blasto-phagus piniperda, Blitophaga undata, Bruchus rufimanus, Bruchus pisorum, Bruchus lentis, Byctiscus betulae, Cassida nebulosa, Cerotoma trifurcata, Cetonia aurata, Ceuthorrhynchus assimilis, Ceuthorrhynchus napi, Chaetocnema tibialis, Chiloloba acuta, Conoderus vespertinus, Crioceris asparagi, Ctenicera ssp., Diabrotica longicornis, Diabrotica semipunctata, Diabrotica punctata, Diabrotica speciosa, Diabrotica virgifera, Dicladispa armigera, Epila-chna varivestis, Epitrix hirtipennis, Eutinobothrus brasiliensis, Holotrichia bicolor, Holotrichia consanguinea, Holotrichia serrata, Hylobius abietis, Hypera brunneipennis, Hypera postica, Ips typographus, Lema bilineata, Lema melanopus, Leptinotarsa decemlineata, Lepidiota stigma, Limonius califomicus, Lissorhoptrus oryzophilus, Maladera indica, Melanotus communis, Meligethes aeneus, Melolontha hippocastani, Melolontha melolontha, Oberea brevis, Oulema oryzae, Ortiorrhynchus sulcatus, Otiorrhynchus ovatus, Phaedon cochleariae, Phyllobius pyri, Phyllotreta chrysocephala, Phyllophaga sp., Phyllopertha horticola, Phyllotreta nemorum, Phyllotreta striolata, Popillia japonica, Sitona lineatus and Sitophilus granaria, flies, mosquitoes (Diptera), Atherigona orientalis, Calliphora vicina, Ceratitis capitata, Chrysomya bezziana, Chrysomya hominivorax, Chrysomya macellaria, Chrysops discalis, Chrysops silacea, Chrysops atlanticus, Cochliomyia hominivorax, Contarinia sorghicola Cordylobia anthropophaga, Culicoides furens, Culiseta inornata, Culiseta melanura, Dacus cucurbi-tae, Dacus oleae, Dasineura brassicae, Delia antique, Delia coarctata, Delia platura, Delia radicum, Dermatobia hominis, Fannia canicularis, Geomyza Tripunctata, Gaster-ophilus intestinalis, Glossina morsitans, Glossina palpalis, Glossina fuscipes, Glossina tachinoides, Haematobia irritans, Haplodiplosis equestris, Hippelates spp., Hylemyia platura, Hypoderma lineata, Leptoconops torrens, Liriomyza sativae, Liriomyza trifolii, Lucilia caprina, Lucilia cuprina, Lucilia sericata, Lycoria pectoralis, Mansonia titillanus, Mayetiola destructor, Melanagromyza obtuse, Muscina stabulans, Oestrus ovis, Ophiomyia phaseli, Opomyza florum, Orseolia oryzae, Oscinella frit, Pegomya hysocyami, Phorbia antiqua, Phorbia brassicae, Phor-bia coarctata, Phlebotomus argentipes, Psorophora columbiae, Psila rosae, Psoro-phora discolor, Prosimulium mixtum, Rhagoletis cerasi, Rhagoletis pomonella, Sar-cophaga haemorrhoidalis, Sarcophaga sp., Simulium vittatum, Stomoxys calcitrans, Tabanus bovinus, Tabanus atratus, Tabanus lineola, and Tabanus similis, Tipula ol-eracea, and Tipula paludosa, thrips (Thysanoptera), Dichromothrips corbetti, Dichromothrips ssp , Frankliniella fusca, Frankliniella occidentalis, Frankliniella tritici, Scirtothrips citri, Scirtothrips dorsalis, Thrips oryzae, Thrips palmi and Thrips tabaci, termites (Isoptera), Calotermes flavicollis, Coptotermes formosanus, Heterotermes aureus, Leucotermes flavipes, Microtermes obesi, Odontotermes obesus, Reticulitermes flavipes, Termes natalensis.

Cockroaches (Blattaria - Blattodea), Blattella germanica, Penplaneta americana, Periplaneta japonica and Blatta orientalis, true bugs (Hemiptera), Acrosternum hilare, Acyrtho-siphon pisum, Acyrthosiphon onobrychis, Adelges laricis, Amrasca biguttula biguttula, Amrasca devastans, Amritodus atkinsoni, Aphidula nasturtii, Aphis fabae, Aphis forbesi, Aphis pomi, Aphis gossypii, Aphis crassivora, Aphis grossulariae, Aphis schneideri, Aphis spiraecola, Aphis sambuci, Aulacorthum solani, Bemisia argentifolii, Bemisia tabaci, Brachycaudus cardui, Brachy-caudus helichrysi, Brachycaudus persicae, Brachycaudus prunicola, Brevicoryne brassicae, Capitophorus horni, Cerosipha gossypii, Chaetosiphon fragaefolii, Cicadulina spp., Clavigralla gibbosa, Cryptomyzus ribis, Dreyfusia nordmannianae, Dreyfusia piceae, Dysdercus cingulatus, Dysaphis radicola, Dysaulacorthum pseudosolani, Dysaphis plantaginea, Dysaphis pyri, Empoasca fabae, Hyalopterus pruni, Hyperomyzus lactucae, Idioscopus spp. Leptoglossus phyllopus, Leptocorisa acuta, Lygus lineolaris, Lygus pratensis, Macrosiphum avenae, Macrosiphum euphorbiae, Ma-crosiphon rosae, Megoura viciae, Melanaphis pyrarius, Metopolophium dirhodum, My-zus persicae, Myzus ascalonicus, Myzus cerasi, Myzus varians, Nezara viridula, Nasonovia ribis-nigri, Nilaparvata lugens, Nephotettix virescens, Nephotettix nigropictus, Pemphigus bursarius, Perkinsiella saccharicida, Peregrinus maidis, Phorodon humuli, Planococcus spp., Pseudococcus spp., Pyrilla perpusilla, Psylla mail, Psylla piri, Rhopalomyzus ascalonicus, Rhopalosiphum maidis, Rhopalosi-phum padi, Rhopalosiphum insertum, Sappaphis mala, Sappaphis mail, Schizaphis graminum, Schizoneura lanuginosa, Sitobion avenae, Sogatella furcifera, Trialeurodes vaporariorum, Toxoptera aurantiia, Psylla spp., Rhopalosiphum spp., Sitobion spp., Ants, bees, wasps, sawflies (Hymenoptera), Athalia rosae, Atta cephalotes, Atta capiguara, Atta cephalotes, Atta laevigata, Atta robusta, Atta sexdens, Atta texana, Crematogaster spp., Hoplocampa minuta, Hoplocampa testudinea, Monomorium pha-raonis, Solenopsis geminata, Solenopsis invicta, Solenopsis richteri, Solenopsis xyloni, Pogonomyrmex barbatus, Pogonomyrmex californicus, Pheidole megacephala, Dasy-mutilla occidentalis, Bombus spp. Vespula squamosa, Paravespula vulgaris, Paraves-pula pennsylvanica, Paravespula germanica, Dolichovespula maculata, Vespa crabro, Polistes rubiginosa, Camponotus floridanus, and Linepithema humile, Crickets, grasshoppers, locusts (Orthoptera), Acheta domestica, Gryllotalpa gryllo-talpa, Locusta migratoria, Melanoplus bivittatus, Melanoplus femurrubrum, Melanoplus mexicanus, Melanoplus sanguinipes, Melanoplus spretus, Nomadacris septemfasciata, Schistocerca americana, Schistocerca gregaria, Dociostaurus maroccanus, Tachycines asynamorus, Oedaleus senegalensis, Zonozerus variegatus, Hieroglyphus daganensis, Kraussaria angulifera, Calliptamus italicus, Chortoicetes terminifera, and Locustana pardalina, Arachnoidea, such as arachnids (Acarina), of the families Argasidae, Ixodidae and Sarcoptidae, such as Amblyomma americanum, Amblyomma variegatum, Ambryomma maculatum, Argas persicus, Boophilus annulatus, Boophilus decoloratus, Boophilus microplus, Dermacentor silvarum, Dermacentor andersoni, Dermacentor variabilis, Hyalomma truncatum, Ixodes ricinus, Ixodes rubicundus, Ixodes scapularis, Ixodes holocyclus, Ixodes pacificus, Ornithodorus moubata, Ornithodorus hermsi, Ornithodo-rus turicata, Ornithonyssus bacoti, Otobius megnini, Dermanyssus gallinae, Psoroptes ovis, Rhipicephalus sanguineus, Rhipicephalus appendiculatus, Rhipicephalus evertsi, Sarcoptes scabiei, and Eriophyidae spp. such as Aculus schlechtendali, Phyllocoptrata oleivora and Eriophyes sheldoni; Tarsonemidae spp. such as Phytonemus pallidus and Polyphagotarsonemus latus; Tenuipalpidae spp. such as Brevipalpus phoenicis; Tetra-nychidae spp. such as Tetranychus cinnabarinus, Tetranychus kanzawai, Tetranychus pacificus, Tetranychus telarius and Tetranychus urticae, Panonychus ulmi, Panony-chus citri, and Oligonychus pratensis; Araneida, Latrodectus mactans, and Loxos-celes reclusa, fleas (Siphonaptera), Ctenocephalides felis, Ctenocephalides canis, Xenopsylla cheopis, Pulex irritans, Tunga penetrans, and Nosopsyllus fasciatus, silverfish, firebrat (Thysanura), Lepisma saccharina and Thermobia domestica, centipedes (Chilopoda), Scutigera coleoptrata, millipedes (Diplopoda), Narceus spp., Earwigs (DermapteraJ, forficula auricularia, lice (Phthiraptera), Pediculus humanus capitis, Pediculus humanus corporis, Pthi-rus pubis, Haematopinus eurystemus, Haematopinus suis, Linognathus vituli, Bovicola bovis, Menopon gallinae, Menacanthus stramineus and Solenopotes capillatus, plant parasitic nematodes such as root-knot nematodes, Meloidogyne arenaria, Meloi-dogyne chitwoodi, Meloidogyne exigua, Meloidogyne hapla, Meloidogyne incognita, Meloidogyne javanica and other Meloidogyne species; cyst nematodes, Globodera rostochiensis, Globodera pallida, Globodera tabacum and other Globodera species, Heterodera avenae, Heterodera glycines, Heterodera schachtii, Heterodera trifolii, and other Heterodera species; seed gall nematodes, Anguina funesta, Anguina tritici and other Anguina species; stem and foliar nematodes, Aphelenchoides besseyi, Aphelen-choides fragariae, Aphelenchoides ritzemabosi and other Aphelenchoides species; sting nematodes, Belonolaimus longicaudatus and other Belonolaimus species; pine nematodes, Bursaphelenchus xylophilus and other Bursaphelenchus species; ring ne-matodes, Criconema species, Criconemella species, Criconemoides species, and Me-socriconema species; stem and bulb nematodes, Ditylenchus destructor, Ditylenchus dipsaci, Ditylenchus myceliophagus and other Ditylenchus species; awl nematodes, Dolichodorus species; spiral nematodes, Helicotylenchus dihystera, Helicotylenchus multicinctus and other Helicotylenchus species, Rotylenchus robustus and other Roty-lenchus species; sheath nematodes, Hemicycliophora species and Hemicriconemoides species; Hirshmanniella species; lance nematodes, Hoplolaimus columbus, Hoplolai-mus galeatus and other Hoplolaimus species; false root-knot nematodes, Nacobbus aberrans and other Nacobbus species; needle nematodes, Longidorus elongates and other Longidorus species; pin nematodes, Paratylenchus species; lesion nematodes, Pratylenchus brachyurus, Pratylenchus coffeae, Pratylenchus curvitatus, Pratylenchus goodeyi, Pratylencus neglectus, Pratylenchus penetrans, Pratylenchus scribneri, Pratylenchus vulnus, Pratylenchus zeae and other Pratylenchus species; Radinaphelenchus cocophilus and other Radinaphelenchus species; burrowing nematodes, Radopholus similis and other Radopholus species; reniform nematodes, Rotylenchulus reniformis and other Rotylenchulus species; Scutellonema species; stubby root nematodes, Tri-chodorus primitivus and other Trichodorus species; Paratrichodorus minor and other Paratrichodorus species; stunt nematodes, Tylenchorhynchus claytoni, Tylenchorhyn-chus dubius and other Tylenchorhynchus species and Merlinius species; citrus nematodes, Tylenchulus semipenetrans and other Tylenchulus species; dagger nematodes, Xiphinema americanum, Xiphinema index, Xiphinema diversicaudatum and other Xi-phinema species; and other plant parasitic nematode species.

The pesticidal composition according to the invention can be applied to any and all developmental stages of pests, such as egg, larva, pupa, and adult. The pests may be controlled by contacting the target pest, its food supply, habitat, breeding ground or its locus with an effective amount of the composition of present invention.

The composition of the present invention comprising A) Methoxyfenozide B) at least one insecticide selected from Indoxacarb and Emamectin Benzoate C) at least one more insecticide selected from Bifenthrin, Cypermethrin, Deltamethrin, Fenpropathrin, Lambda cyhalotrhin, Acephate, Chlorpyrifos, Profenofos, Quinalphos, Triazophos, Acetamiprid, Clothianidin, Imidacloprid, Thiamethoxam, Novaluron, Lufenuron, Chlorfluazuron, Pyriproxyfen, Chlorantraniliprole, Cyantraniliprole, Flubendiamide, Abamectin, Spinetoram, Spinosad, Chlorfenapyr, Diafenthiuron, Fipronil, Pyridalyl and Tolfenpyrad with one or more inactive excipients.

One or more inactive excipient is selected from including but not limited to dispersant, anti-freezing agent, anti-foam agent, wetting agent, suspension aid, anti-microbial agent, thickener, quick coating agent or sticking agents (also referred to as “stickers” or “binders”) and buffering agent.

Surfactants that are used as dispersants have the ability to adsorb strongly onto a particle surface and provide a charged or stearic barrier to re-aggregation of particles. The most commonly used surfactants are anionic, non-ionic, or mixtures of the two types. For wettable powder formulations, the most common dispersants are sodium lignosulphonates. For suspension concentrates, very good adsorption and stabilization are obtained using polyelectrolytes, such as sodium naphthalene sulphonate formaldehyde condensates. Tristyrylphenolethoxylate phosphate esters are also used. Nonionics such as alkylarylethylene oxide condensates and EO-PO block copolymers are sometimes combined with anionics as dispersants for suspension concentrates. In recent years, new types of very high molecular weight polymeric surfactants have been developed as dispersants. These have very long hydrophobic ‘backbones’ and a large number of ethylene oxide chains forming the ‘teeth’ of a ‘comb’ surfactant. These high molecular weight polymers can give very good long-term stability to suspension concentrates because the hydrophobic backbones have many anchoring points onto the particle surfaces. Examples of dispersants used herein include but not limited to sodium lignosulphonates; sodium naphthalene sulphonate formaldehyde condensates; tristyrylphenolethoxylate phosphate esters; aliphatic alcohol ethoxylates; alky ethoxylates; EO-PO block copolymers; and graft copolymers or mixtures thereof.

Anti-freezing agent as used herein can be selected from the group consisting of polyethylene glycols, methoxypolyethylene glycols, polypropylene glycols, polybutylene glycols, glycerin and ethylene glycol.

Water-based formulations often cause foam during mixing operations in production. In order to reduce the tendency to foam, anti-foam agents are often added either during the production stage or before filling into bottles. Generally, there are two types of anti-foam agents, namely silicones and non-silicones. Silicones are usually aqueous emulsions of dimethyl polysiloxane while the non-silicone anti-foam agents are water-insoluble oils, such as octanol and nonanol, or silica. In both cases, the function of the anti-foam agent is to displace the surfactant from the air-water interface.

A wetting agent is a substance that when added to a liquid increases the spreading or penetration power of the liquid by reducing the interfacial tension between the liquid and the surface on which it is spreading. Wetting agents are used for two main functions in agrochemical formulations: during processing and manufacture to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates; and during mixing of a product with water in a spray tank or other vessel to reduce the wetting time of wettable powders and to improve the penetration of water into water-dispersible granules. Examples of wetting agents used in wettable powder, suspension concentrate, and water-dispersible granule formulations include but not limited to sodium lauryl sulphate; sodium dioctylsulphosuccinate; alkyl phenol ethoxylates; and aliphatic alcohol ethoxylates and the salts thereof which are standard in agricultureor mixtures thereof.

Suspension aid in the present description denotes a natural or synthetic, organic or inorganic material with which the active substance is combined in order to facilitate its application to the plant, to the seeds or to the soil. This carrier is hence generally inert, and it must be agriculturally acceptable, in particular to the plant being treated. The carrier may be solid (clays, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, and the like or mixtures thereof) or liquid (water, alcohols, ketones, petroleum fractions, aromatic or paraffinic hydrocarbons, chlorinated hydrocarbons, liquefied gases, and the like or mixtures thereof).

Biocides / Microorganisms cause spoilage of formulated products. Therefore anti-microbial agents are used to eliminate or reduce their effect. Examples of such agents include, but are not limited to: propionic acid and its sodium salt; sorbic acid and its sodium or potassium salts; benzoic acid and its sodium salt; p-hydroxy benzoic acid sodium salt; methyl p-hydroxy benzoate; and biocide such as sodium benzoate, 1,2-benzisothiazoline-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, potassium sorbate, parahydroxy benzoates or mixtures thereof.

Thickeners or gelling agents are used mainly in the formulation of suspension concentrates, emulsions and suspo-emulsions to modify the rheology or flow properties of the liquid and to prevent separation and settling of the dispersed particles or droplets. Thickening, gelling, and anti-settling agents generally fall into two categories, namely water-insoluble particulates and water-soluble polymers. It is possible to produce suspension concentrate formulations using clays and silicas. Examples of these types of materials, include, but are limited to, montmorillonite, bentonite; magnesium aluminum silicate; and attapulgite. Water-soluble polysaccharides have been used as thickening-gelling agents for many years. The types of polysaccharides most commonly used are natural extracts of seeds and seaweeds are synthetic derivatives of cellulose or mixtures thereof. Examples of these types of materials include, but are not limited to, guar gum; locust bean gum; carrageenam; xanthan gum; alginates; methyl cellulose; sodium carboxymethyl cellulose (SCMC); hydroxyethyl cellulose (HEC) or mixtures thereof. Other types of anti-settling agents are based on modified starches, polyacrylates, polyvinyl alcohol and polyethylene oxide or mixtures.

The quick coating agent can be a conventionally available sticker, for example polyesters, polyamides, poly- carbonates, polyurea and polyurethanes, acrylate polymers and copolymers, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose derivatives, vinylalcohol, vinylacetate and vinylpyrrolidone polymers and copolymers, polyethers, epoxy, phenolic and melamine resins, polyolefins and define copolymersand mixtures thereof. Examples of preferred polymers are acrylate polymers such as poly(methacrylate), poly(ethyl methacrylate), poly(methylmethacrylate), acrylate copoylmers and styrene-acrylic copolymers as defined herein below, poly(styrene-co maleic anhydride), cellulosic polymers such as ethyl cellulose, cellulose acetate, cellulose acetatebutyrate, acetylated mono, di, and triglycerides, poly(vinylpyrrolidone), vinyl acetate polymers and copolymers, poly(alkylene glycol), styrene butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more of these. Polymers that are biodegradable are also useful in the present invention. As used herein, a polymer is biodegradable if is not water soluble, but is degraded over a period of several weeks when placed in an application environment. Examples of biodegradable polymers that are useful in the present invention include biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch esteraliphatic polyester blends, modified corn starch, polycaprolactone, poly(namylmethacrylate), wood rosin, polyanhydrides, polyvinylalcohol, polyhydroxybutyratevalerate, biodegradable aliphatic polyesters, and polyhydroxybutyrate or mixtures thereof.

Buffering agent as used herein is selected from group consisting of calcium hydroxyapatite, Potassium Dihydrogen Phosphate, Sodium Hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphates, carbonated calcium phosphates, amine monomers, lactate dehydrogenase and magnesium hydroxide.

The solvent for the formulation of the present invention may include water, water-soluble alcohols and dihydroxy alcohol ethers. The water-soluble alcohol which can be used in the present invention may be lower alcohols or water-soluble macromolecular alcohols. The term "lower alcohol", as used herein, represents an alcohol having 1-4 carbon atoms, such as methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol, etc. Macromolecular alcohol is not limited, as long as it may be dissolved in water in a suitable amount range, polyethylene glycol, sorbitol, glucitol, etc. The examples of suitable dihydroxy alcohol ethers used in the present invention may be dihydroxy alcohol alkyl ethers or dihydroxy alcohol aryl ethers. The examples of dihydroxy alcohol alkyl ether include ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether, dipropylene glycol ethyl ether, etc. The examples of dihydroxy alcohol aryl ethers include ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, dipropylene glycol phenyl ether, and the like. Any of the above mentioned solvent can be used either alone or in combination thereof.

The wettable dry granules (WDG) can be applied after disintegration and dispersion in water. Water dispersible granules can be formed by a) agglomeration, b) spray drying, or c) extrusion techniques.

WDG formulations offer a number of advantages in packaging, ease of handling and safety. The WDG are preferably of uniform size and which are free flowing, low dusting and readily disperse in water to form a homogenous solution of very small particles which may pass through conventional spray nozzles. Ideally WDG formulations when dispersed in water under gentle agitation for five minutes have residues of less than 0.01% on a 150 µm sieve screen and less than 0.5% on a 53 µm screen. The granules can usually be measured accurately by volume which is convenient for the end user.

The SC formulation can be prepared by below described method;
STEP-I: Adding anti-microbial agent and gum in water under continuous stirring followed by slow addition. Continuing stirring until homogeneous dispersion is formed.

STEP-II: Mixing anti-freezing agent, dispersant, wetting agent, anti-microbial agent and anti-foaming agent in water for 30 minute until homogeneous solution is formed. Finally add A) Methoxyfenozide B) insecticide selected from Indoxacarb and Emamectin Benzoate C) at least one more insecticide selected from Bifenthrin, Cypermethrin, Deltamethrin, Fenpropathrin, Lambda cyhalotrhin, Acephate, Chlorpyrifos, Profenofos, Quinalphos, Triazophos, Acetamiprid, Clothianidin, Imidacloprid, Thiamethoxam, Novaluron, Lufenuron, Chlorfluazuron, Pyriproxyfen, Chlorantraniliprole, Cyantraniliprole, Flubendiamide, Abamectin, Spinetoram, Spinosad, Chlorfenapyr, Diafenthiuron, Fipronil, Pyridalyl and Tolfenpyrad which are standard in agriculture or mixture thereof is added slowly under continuous stirring at 30 minute till homogeneous dispersion is obtained. Milling the slurry through bead mill until required particle size is achieved.

Step-III: Adding rest of water, anti-foaming agent and gum solution under continuous stirring to get desired viscosity of the suspension. Continue stirring for about 4 hr. to obtain homogeneous formulation.

The process for preparing the present pesticidal composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However all such variation and modification is still covered by the scope of present invention.

List of inactive agent which may be used in the present invention are listed below but not limited to:

Inactive excipients used in SC formulation
Excipients Function
Acrylic graft copolymer, Alkylated naphthalene sulfonate, sodium salt, Sodium salt of naphthalene sulfonate condensate, Sodium ligno sulfonate Dispersing agent
Polyalkoxy alkyl ether, Ethylene oxide/propylene oxide block copolymer Dispersing agent, Emulsifier
Polyarylphenyl ether phosphate, Ethoxylated Fatty Alcohol Dispersing agent & Wetting agent
Trisiloxane ethoxylate Wetting agent & Spreader
Sodium dioctyl sulfosuccinate Wetting agent & Emulsifier
Silicone antifoam emulsion Antifoam
Polysaccharide Rheology Modifier,Thickner
Glycol (Monoethylene glycol, Diethylene glycol, Polypropylene glycol, Polyethylene glycol), Glycerene Antifreezing Agent
1,2-benzisothiazolin-3-one, Sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, Formaldehyde, Sodium o-phenylphenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one Biocide/Preservative
Aluminum Magnesium Silicate Suspending aid
Silicone dioxide Suspending aid, Anticaking agent
Polydimethyl siloxane Antifoaming agent
Organo modified Trisiloxane Spreader
Poly glycerol ester Sticker, Penetrant
Poly ether Deposition aid

Inactive excipients used in WG formulation
Excipients Function
Sodium salt of naphthalene sulfonate condensate, Modified polyacrylate copolymer, Sodium polycarboxylate, Sodium Ligno sulfonate, Alkyl naphthalene sulfonate condensate, sodium salt, Dispersing Agent
Polyacrylate co-polymer Dispersing Agent, Stabilizer, Emulsifier
Alcohol block co-polymer Co-dispersant
Blend of naphthalene sulfonate condensate & phenol sulfonate condensate Wetting Agent & Dispersing Agent
blend of naphthalene sulfonate condensate, Sodium dodecylbenzene sulfonate, Sodium lauryl sulfate, Blend of alkyl naphthalene sulfonate and anionic wetting agent, Sodium n-butyl naphthalene sulfonate, Sodium isopropyl naphthalene sulfonate, Blend of sodium alkyl aryl sulfonates Wetting Agent
Corn starch Binder, Filler
Silicon dioxide Suspending agent, Anti-caking Agent, Filler
Urea formaldehyde resin / Urea-methanol Anti caking agent
Lactose, China clay/ Kaolin, Titanium dioxide, Talcum powder, Diatomaceous earth Filler
Polyvinylpyrrolidone Binder
Silicone antifoam emulsion Defoaming agent
Fatty amine ethoxylate Wetting agent, Dispersing agent, Stabilizers, Sanitizers, Defoaming agent

Inactive excipients used in SE Formulation
Excipients Function
n- Octanol Solvent
Octyl Phenol Ethoxylate, Polyoxyethylene (8) nonyl phenol, Sodium dioctyl sulfosuccinate Wetting agent & Emulsifier
Acrylic graft copolymer Dispersing agent
Polyalkoxy alkyl ether, Ethylene oxide/propylene oxide block copolymer, Sodium salt of naphthalene sulfonate condensate Dispersing agent & Emulsifier
Polyarylphenyl ether phosphate Dispersing agent & Wetting agent
Ethoxylated Fatty Alcohol Co-dispersant/Wetting agent
Trisiloxane ethoxylate Spreader & Wetting agent
Silicone antifoam emulsion Antifoam
Silicone dioxide Suspending aid, Ant caking agent
Polysaccharide Rheology Modifier,Thickner
Glycol (Monoethylene glycol, Diethylene glycol, Polypropylene glycol, Polyethylene glycol) Antifreezing Agent
1,2-benzisothiazolin-3-one, Sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, Formaldehyde Biocide/Preservative

Inactive excipients used in EC (Emulsifiable Concentrate) formulation
Excipients Function
Mixture of heavy aromatic hydrocarbons / C IX, Xylene, n-Butanol (NBA), Solvent - C-9, N-Methyl-2-pyrrolidone Solvent
Polyaryl Phenol Ethoxylate Emulsifiers, Wetting agents, Dispersants, Stabilizers
Calcium Dodecyl Benzene Sulphonate, Blend of Polyaryl phenol ethoxylate & calcium dodecyl benzene sulfonate Emulsifier
Alkyl polyethylene glycol ether Spreader, Sticker, Penetrant, Surface tension reducer
Polyvinylpyrrolidone Sticker, Surface tension reducer, Binder

The process for preparing the present agrochemical composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the composition. However all such variation and modification is still covered by the scope of present invention.

EXAMPLES
Example 1 Methoxyfenozide 20%+ Indoxacarb 7.5%+Bifenthrin 5% SC
Chemical Composition Percent (% w/w)
Methoxyfenozide a.i. 20.0
Indoxacarb a.i. 7.5
Bifenthrin a.i. 5.0
Ethoxylated Fatty Alcohol 2.0
Acrylic graft copolymer 3.0
Alkylated naphtalene sulfonate, sodium salt 0.5
Silicone antifoam 0.5
1,2-benzisothiazolin-3-one 0.20
Mono Ethylene Glycol 5.0
Polysaccharides 0.15
Trisiloxane ethoxylate 2.0
Water QS
TOTAL 100.0

Process: Manufacturing process
Step 1 Gum Solution should be made 12-18 hour prior to use. Take required quantity of water, biocide, and defoamer and homogenise, then slowly add gum powder to it and stir till complete dissolution.
Step 2 Charge required quantity of DM water need to be taken in designated vessel for Suspension concentrate production.
Step 3 Add required quantity of Wetting agent, anti-freezing, dispersing agent & suspending agents and homogenise the contents for 45 – 60 minutes using high shear homogeniser.
Step 4 Then add technical and other remaining adjuvants excluding ‘thickener’ are added to it and homogenised to get uniform slurry ready for grinding.
Step 5 Before grinding half the quantity of antifoam was added and then material was subjected to grinding in Dyno mill till desired particle size is achieved.
Step 6 Half quantity of the antifoam was added after grinding process completes and before sampling for in process analysis.
Step 7 Finally add gum solution to this formulation and send to QC for quality check.

Storage stability study of example-1 Methoxyfenozide 20%+ Indoxacarb 7.5%+Bifenthrin 5% SC

Parameters Specification (In house) Initial Stability (for 14 days)
At 54±2 0C At 0±2 0C
Description White colour flowable liquid Complies Complies Complies
Methoxyfenozide content percent by mass 19.0 to 21.0 20.19 20.16 20.18
Indoxacarb content percent by mass 7.125 to 8.25 7.57 7.55 7.57
Bifenthrin content percent by mass 4.75 to 5.5 5.13 5.05 5.07
Methoxyfenozide suspensibility percent mini. 80 98.95 97.10 98.80
Indoxacarb suspensibility percent mini. 80 97.72 95.80 96.95
Bifenthrin suspensibility percent mini. 80 96.98 95.10 95.85
pH range (1% aq. Suspension) 5.5 to7.5 7.15 7.13 7.15
Pourability 95 % min 98.50 97.70 97.60
Specific gravity 1.05 – 1.15 1.07 1.08 1.07
Viscosity at spindle no.62, 20 rpm 350 -800 cps 450 480 485
Particle size (micron) D50 <3, D90 <10 2.2, 7.9 2.4, 8.1 2.7, 8.5
Persistent foam ml (after 1 minute) max. 60 5 5 5

Room temperature storage data
Parameters Specification (In house) Study Duration
1 month 6 month 12 months 24 months
Description White colour flowable liquid Complies Complies Complies Complies
Methoxyfenozide content percent by mass 19.0 to 21.0 20.19 20.19 20.18 20.17
Indoxacarb content percent by mass 7.125 to 8.25 7.57 7.57 7.56 7.55
Bifenthrin content percent by mass 4.75 to 5.5 5.13 5.12 5.11 5.09
Methoxyfenozide suspensibility percent mini. 80 98.89 98.85 98.51 98.05
Indoxacarb suspensibility percent mini. 80 97.70 97.65 97.51 97.09
Bifenthrin suspensibility percent mini. 80 96.95 96.51 96.05 95.81
pH range (1% aq. Suspension) 5.5 to7.5 7.15 7.15 7.14 7.14
Pourability 95 % min 98.50 98.40 97.20 96.40
Specific gravity 1.05 – 1.15 1.07 1.07 1.08 1.08
Viscosity at spindle no.62, 20 rpm 350 -800 cps 450 455 460 480
Particle size (micron) D50 <3, D90 <10 2.2, 8 2.2, 8.1 2.3, 8.1 2.4, 8.1
Persistent foam ml (after 1 minute) max. 60 5 5 5 5

Example 2: Methoxyfenozide 20%+Indoxacarb 7.5%+Bifenthrin 5% ZE
Chemical Composition Percent (% w/w)
Methoxyfenozide a.i. 20.0
Indoxacarb a.i. 7.50
Bifenthrin a.i. 5.00
Polyurathane polymer 1.00
Solvent C-9 5.00
Ethoxylated polypropylene oxide 0.15
Sodium salt of naphthalene sulfonate condensate 0.50
1,2-benzisothiazolin-3-one 0.10
Mono Ethylene Glycol 3.00
Octylphenol Ethoxylate 4.00
Ethoxylated polyarylphenol 1.00
PolyarylPhenyl Ether Sulphate 0.50
Acrylic Polymer Amine Salt 0.15
Polysaccharides 0.15
Silicone antifoam 0.50
Water QS
TOTAL 100.0

Process: Manufacturing process
Part 1 Preparation of CS (Capsule suspension) formulation
Step 1 Oil Phase: Take required quantity C-9 Solvent in vessel then add required quantity of Technical and Add Polyurathene polymer, homogenise for approx. for 1 hours.
Step 2 Aqueous Phase: Take required quantity of water Add required quantity of Wetting agent, dispersing agent & Monoethylene Glycol and homogenise the contents for 1 hour.
Step 3 Now mix the oil phase slowly in aqueous phase then stir for another 1 hours.
Step 4 Finally add required quantity of 2% of xanthum gum solution to this formulation
Step 5 Final product is sent for QC approval.
Part 2 Preparation of SE (Suspo emulsion) formulation
Step 1 Gum Solution should be made 12-18 hour prior to use. Take required quantity of water, biocide, and defoamer and homogenise, then slowly add gum powder to it and stir till complete dissolution.
Step 2 Oil phase is made by mixing required quantity of oil soluble emulsifier in required quantity of solvent and technical
Step 3 Simultaneously make aqueous phase by mixing surfactants, antifreeze, antifoam, suspending agent in water. Once homogenise add technical to this solution and form a slurry using high shear homogeniser for 60 minutes and then milled through Bead Mill.
Step 4 Once both phases are ready add Oil phase to aqueous phase slowly under high shear homogenization.
Step 5 After complete addition stir the mixture for 60 more minutes under high shear stirring.
Step 6 Now Final Formulation is sent for quality check.
Part 3 Mixing of Capsule Suspesion (CS) and Suspo emulsion (SE)
Step 1 After getting approval from QC department SE part is added in CS Vessel and homogenised for 30 minutes.
Step 2 Finally remaining 2% Xanthum Gum is added to it and homogenised for 20 minutes.
Step 3 Now Final Formulation is sent for quality check.
Step 4 After approval material is packed in required pack sizes.

Storage stability Study-Methoxyfenozide 20% + Indoxacarb 7.5% + Bifenthrin 5% ZE
Parameters Specification (In house) Initial Stability (for 14 days)
At 54±2 0C At 0±2 0C
Description White colour flowable liquid Complies Complies Complies
Methoxyfenozide content percent by mass 19.0 to 21.0 20.25 20.16 20.24
Indoxacarb content percent by mass 7.125 to 8.25 7.59 7.51 7.57
Bifenthrin content percent by mass 4.75 to 5.5 5.17 5.05 5.16
Methoxyfenozide suspensibility percent mini. 80 98.98 97.01 98.87
Indoxacarb suspensibility percent mini. 80 97.87 95.08 97.54
Bifenthrin suspensibility percent mini. 80 96.92 95.05 95.98
pH range (1% aq. Suspension) 5.5 to7.5 7.08 7.07 7.08
Pourability 95 % min 98.50 97.70 97.60
Specific gravity 1.05 – 1.15 1.09 1.08 1.09
Viscosity at spindle no.62, 20 rpm 350 -800 cps 510 550 560
Particle size (micron) D50 <3, D90 <10 2.2, 7.9 2.8, 9.2 2.7, 8.5
Persistent foam ml (after 1 minute) max. 60 3 3 3

Room temperature storage data
Parameters Specification (In house) Study Duration
1 month 6 month 12 months 24 months
Description White colour flowable liquid Complies Complies Complies Complies
Methoxyfenozide content percent by mass 19.0 to 21.0 20.25 20.24 20.22 20.19
Indoxacarb content percent by mass 7.125 to 8.25 7.59 7.57 7.56 7.54
Bifenthrin content percent by mass 4.75 to 5.5 5.16 5.15 5.11 5.08
Methoxyfenozide suspensibility percent mini. 80 98.88 98.81 98.53 98.07
Indoxacarb suspensibility percent mini. 80 97.75 97.57 97.45 97.02
Bifenthrin suspensibility percent mini. 80 96.91 96.57 96.14 95.15
pH range (1% aq. Suspension) 5.5 to7.5 7.08 7.08 7.08 7.08
Pourability 95 % min 98.50 98.40 97.20 96.40
Specific gravity 1.05 – 1.15 1.09 1.09 1.09 1.08
Viscosity at spindle no.62, 20 rpm 350 -800 cps 510 516 522 536
Particle size (micron) D50 <3, D90 <10 2.2, 8 2.2, 8.1 2.8, 8.9 2.8, 9.1
Persistent foam ml (after 1 minute) max. 60 3 3 3 3

Example 3- Methoxyfenozide 14% +Indoxacarb 5% +Profenofos 20% EC
Chemical Composition Percent (% w/w)
Methoxyfenozide a.i. 14.00
Indoxacarb a.i. 5.00
Profenofos a.i. 20.00
Polyaryl phenol ethoxylate & calcium dodecyl benzene sulfonate 8.00
N-Methyl-2-pyrrolidone 7.00
Solvent - C-9 Q.S.
TOTAL 100.00

Process: Manufacturing process Methoxyfenozide 14% +Indoxacarb 5% +Profenofos 20% Emulsifiable Concentration (EC)
Step 1 Charge required quantity of solvent and then mix the technical into this solvent till its completely dissolved
Step 2 Now add surfactants dose as per screening ration.
Step 3 Final product is sent for QC approval.
Step 4 After approval material is packed in requied pack sizes.

Storage stability Study-Methoxyfenozide 14% +Indoxacarb 5% +Profenofos 20% EC
Parameters Specification (In house) Initial Stability (for 14 days)
At 54±2 0C At 0±2 0C
Description Yellowish stable clear liquid. Complies Complies Complies
Methoxyfenozide content percent by mass 13.3 to 14.7 14.05 14.03 14.05
Indoxacarb content percent by mass 4.75 to 5.5 5.04 5.01 5.04
Bifenthrin content percent by mass 19.0 to 21.0 20.06 20.04 20.06
Emulsion stability Max. 2ml creaming or sediment after 1 hour Complies Complies Complies
pH (5% in DM water) 6.0 - 8.0 7.08 7.05 7.08
Flash point Above 24.5 0C 43 43 43
Cold test Separation or creaming max. 2 ml after 1 hour Complies Complies Complies

Room temperature storage data
Parameters Specification (In house) Study Duration
1 month 6 month 12 month 24 month
Description Yellowish stable clear liquid. Complies Complies Complies Complies
Methoxyfenozide content percent by mass 13.3 to 14.7 14.05 14.04 14.04 14.03
Indoxacarb content percent by mass 4.75 to 5.5 5.04 5.04 5.03 5.02
Bifenthrin content percent by mass 19.0 to 21.0 20.06 20.05 20.04 20.04
Emulsion stability Max. 2ml creaming or sediment after 1 hour Complies Complies Complies Complies
pH (5% in DM water) 6.0 - 8.0 7.08 7.08 7.07 7.05
Flash point Above 24.5 0C Complies Complies Complies Complies
Cold test Separation or creaming max. 2 ml after 1 hour 43 43 43 43

Example 4-Methoxyfenozide 35% + Indoxacarb 12% + Emamectin Benzoate 2% WG
Chemical Composition Percent (% w/w)
Methoxyfenozide a.i. 35.0
Indoxacarb a.i. 12.0
Emamectin Benzoate a.i. 2.0
Alkylated naphthalene sulfonate, sodium salt 6.0
Sodium lauryl sulfate 4.0
Silicone antifoam 1.0
Precipitated silica
Lactose 2.0
Corn starch 15.0
China Clay QS
TOTAL 100.0

Manufacturing process: Methoxyfenozide 35% + Indoxacarb 12% + Emamectin Benzoate 2% Water Dispersible Granules (WG) by extrusion method
Step 1 Charge the required quantity of filler, wetting agent, dispersing agent, and suspending agent, & technical in premixing blender for homogenization for 30 minutes.
Step 2 Pre-blended material is then grinded through Jet mill/ air classifier mills. Finely grinded material is blended in post blender till it becomes homogeneous. (for approx 1.5 hr)
Step 3 Finely grinded powder is mixed with required quantity of water to form extrudable dough.
Step 4 Dough is passed through extruder to get granules of required size.
Step 5 Wet granules are passed through Fluidized bed drier and further graded using vibrating screens.
Step 6 Final product is sent for QC approval.
Step 7 After approval material is packed in required pack sizes.

Storage stability study-Methoxyfenozide 35% + Indoxacarb 12% + Emamectin Benzoate 2% WG
Parameters Specification (In house) Initial Stability (for 14 days)
At 54±2 0C At 0±2 0C
Description Off white colour granules Complies Complies Complies
Methoxyfenozide content percent by mass 33.25 to 36.75 35.12 35.08 35.12
Indoxacarb content percent by mass 11.4 to 12.6 12.12 12.06 12.11
Emamectin Benzoate content percent by mass 1.9 to 2.2 2.11 2.09 2.11
Methoxyfenozide suspensibility percent min. 70 96.52 95.12 96.36
Indoxacarb suspensibility percent min. 70 95.45 94.58 95.14
Emamectin Benzoate suspensibility percent min. 70 96.88 96.01 96.25
pH range (1% aq. Suspension) 5.5 to7.5 7.2 7.0 7.1
Wettability sec. max. 60 8 9 9
Wet Sieve(45 micron ) percent by mass min. 98.5 99.6 99.3 99.5
Bulk density (g/ml) 0.45 to 0.75 0.51 0.51 0.51
Moisture content percent by mass max. Max. 2.0% 1 0.8 1

Room temperature storage data
Parameters Specification (In house) Study Duration
1 month 6 month 12 months 24 months
Description Off white colour granules Complies Complies Complies Complies
Methoxyfenozide content percent by mass 33.25 to 36.75 35.12 35.11 35.11 35.09
Indoxacarb content percent by mass 11.4 to 12.6 12.11 12.10 12.09 12.07
Emamectin Benzoate content percent by mass 1.9 to 2.2 2.11 2.11 2.10 2.10
Methoxyfenozide suspensibility percent min. 70 96.47 96.35 96.26 95.44
Indoxacarb suspensibility percent min. 70 95.12 94.89 94.65 94.61
Emamectin Benzoate suspensibility percent min. 70 96.74 96.69 96.45 96.31
pH range (1% aq. Suspension) 5.5 to7.5 7.2 7.2 7.1 7.0
Wettability sec. max. 60 8 8 9 9
Wet Sieve(45 micron ) percent by mass min. 98.5 99.6 99.5 99.5 99.4
Bulk density (g/ml) 0.45 to 0.75 0.51 0.51 0.51 0.51
Moisture content percent by mass max. Max. 2.0% 0.8 0.7 0.6 0.4

Example 5-Methoxyfenozide 17.5% + Emamectin benzoate 1% + Bifenthrin 7.5% SC
Chemical Composition Percent (% w/w)
Methoxyfenozide a.i. 17.5
Emamectin benzoate a.i. 1.0
Bifenthrin a.i. 7.5
Acrylic graft copolymer 3.0
Polyalkoxylated Butyl Ether 2.0
Alkylated naphtalene sulfonate, sodium salt 0.5
Silicone antifoam 0.5
1,2-benzisothiazolin-3-one 0.20
Mono Ethylene Glycol 5.0
Polysaccharides 0.15
Water QS
TOTAL 100.0

Manufacturing process
Step 1 Gum Solution should be made 12-18 hour prior to use. Take required quantity of water, biocide, and defoamer and homogenise, then slowly add gum powder to it and stir till complete dissolution.
Step 2 Charge required quantity of DM water need to be taken in designated vessel for Suspension concentrate production.
Step 3 Add required quantity of Wetting agent, anti-freezing, dispersing agent & suspending agents and homogenise the contents for 45 – 60 minutes using high shear homogeniser.
Step 4 Then add technical and other remaining adjuvants excluding ‘thickener’ are added to it and homogenised to get uniform slurry ready for grinding.
Step 5 Before grinding half the quantity of antifoam was added and then material was subjected to grinding in Dyno mill till desired particle size is achieved.
Step 6 Half quantity of the antifoam was added after grinding process completes and before sampling for in process analysis.
Step 7 Finally add gum solution to this formulation and send to QC for quality check.

Storage stability Study-Methoxyfenozide 17.5% + Emamectin benzoate 1% + Bifenthrin 7.5% SC
Parameters Specification (In house) Initial Stability (for 14 days)
At 54±2 0C At 0±2 0C
Description White colour flowable liquid Complies Complies Complies
Methoxyfenozide content percent by mass 16.625 to 18.375 17.58 17.54 17.57
Emamectin Benzoate content percent by mass 0.95 to 1.1 1.05 1.03 1.05
Bifenthrin content percent by mass 7.125 to 8.25 7.61 7.55 7.60
Methoxyfenozide suspensibility percent mini. 80 98.55 96.52 98.80
Emamectin Benzoate suspensibility percent mini. 80 97.86 95.88 97.56
Bifenthrin suspensibility percent mini. 80 95.54 94.50 95.51
pH range (1% aq. Suspension) 5.5 to7.5 7.13 7.11 7.13
Pourability 95 % min 98.50 97.70 97.60
Specific gravity 1.05 – 1.15 1.07 1.08 1.08
Viscosity at spindle no.62, 20 rpm 350 -800 cps 460 490 495
Particle size (micron) D50 <3, D90 <10 2.2, 7.9 2.4, 8.1 2.7, 8.5
Persistent foam ml (after 1 minute) max. 60 5 5 5

Room temperature storage data
Parameters Specification (In house) Study Duration
1 month 6 month 12 months 24 months
Description White colour flowable liquid Complies Complies Complies Complies
Methoxyfenozide content percent by mass 16.625 to 18.375 17.57 17.56 17.55 17.54
Emamectin Benzoate content percent by mass 0.95 to 1.1 1.05 1.05 1.04 1.03
Bifenthrin content percent by mass 7.125 to 8.25 7.60 7.59 7.57 7.55
Methoxyfenozide suspensibility percent mini. 80 98.35 98.85 98.65 96.88
Emamectin Benzoate suspensibility percent mini. 80 97.81 97.65 97.05 96.74
Bifenthrin suspensibility percent mini. 80 95.45 95.32 95.28 95.21
pH range (1% aq. Suspension) 5.5 to7.5 7.13 7.13 7.12 7.11
Pourability 95 % min 98.50 98.40 97.20 96.40
Specific gravity 1.05 – 1.15 1.07 1.07 1.08 1.08
Viscosity at spindle no.62, 20 rpm 350 -800 cps 460 465 470 487
Particle size (micron) D50 <3, D90 <10 2.2, 8 2.2, 8.1 2.4, 8.1 2.4, 8.1
Persistent foam ml (after 1 minute) max. 60 5 5 5 5

Example 6-Methoxyfenozide 17.5% + Emamectin benzoate 1% + Profenofos 30% EC
Composition Percentage (w/w)
Methoxyfenozide a.i. 17.50
Emamectin Benzoate a.i. 1.00
Profenofos a.i. 30.00
Polyaryl phenol ethoxylate & calcium dodecyl benzene sulfonate 8.00
N-Methyl-2-pyrrolidone 7.00
Solvent - C-9 Q.S.
TOTAL 100.00

Manufacturing Process Methoxyfenozide 17.5% + Emamectin benzoate 1% + Profenofos 30% Emulsifiable Concentration (EC)
Step 1 Charge required quantity of solvent and then mix the technical into this solvent till its completely dissolved
Step 2 Now add surfactants dose as per screening ration.
Step 3 Final product is sent for QC approval.
Step 4 After approval material is packed in requied pack sizes.

Storage stability Study: Methoxyfenozide 17.5% + Emamectin benzoate 1% + Profenofos 30% EC
Parameters Specification (In house) Initial Stability (for 14 days)
At 54±2 0C At 0±2 0C
Description Yellowish stable clear liquid. Complies Complies Complies
Methoxyfenozide content percent by mass 16.625 to 18.375 17.55 17.51 17.55
Emamectin Benzoate content percent by mass 0.95 to 1.1 1.09 1.03 1.08
Profenofos content percent by mass 28.5 to 31.5 30.21 30.17 30.19
Emulsion stability Max. 2ml creaming or sediment after 1 hour Complies Complies Complies
pH (5% in DM water) 6.0 - 8.0 7.05 7.04 7.05
Flash point Above 24.5 0C 43 43 43
Cold test Separation or creaming max. 2 ml after 1 hour Complies Complies Complies

Room temperature storage data
Parameters Specification (In house) Study Duration
1 month 6 month 12 month 24 month
Description Yellowish stable clear liquid. Complies Complies Complies Complies
Methoxyfenozide content percent by mass 16.625 to 18.375 17.54 17.54 17.54 17.53
Emamectin Benzoate content percent by mass 0.95 to 1.1 1.09 1.08 1.07 1.05
Profenofos content percent by mass 28.5 to 31.5 30.20 30.19 30.18 30.17
Emulsion stability Max. 2ml creaming or sediment after 1 hour Complies Complies Complies Complies
pH (5% in DM water) 6.0 - 8.0 7.05 7.05 7.05 7.04
Cold test Above 24.5 0C Complies Complies Complies Complies
Flash point Separation or creaming max. 2 ml after 1 hour 43 43 43 43

Example 7-Methoxyfenozide 35% + Emamectin Benzoate 2% +Thiamethoxam 25% WG

Chemical Composition Percent (% w/w)
Methoxyfenozide a.i. 35.0
Emamectin Benzoate a.i. 2.0
Thiamethoxam a.i. 25.0
Alkylated naphthalene sulfonate, sodium salt 6.0
Sodium lauryl sulfate 4.0
Silicone antifoam 1.0
Lactose 10.0
Corn starch 17.0
China Clay QS
TOTAL 100.0

Manufacturing Process Methoxyfenozide 35% + Emamectin Benzoate 2% +Thiamethoxam 25% Water Dispersible Granules (WG) by extrusion method
Step 1 Charge the required quantity of filler, wetting agent, dispersing agent, and suspending agent, & technical in premixing blender for homogenization for 30 minutes.
Step 2 Pre-blended material is then grinded through Jet mill/ air classifier mills. Finely grinded material is blended in post blender till it becomes homogeneous. (for approx 1.5 hr)
Step 3 Finely grinded powder is mixed with required quantity of water to form extrudable dough.
Step 4 Dough is passed through extruder to get granules of required size.
Step 5 Wet granules are passed through Fluidized bed drier and further graded using vibrating screens.
Step 6 Final product is sent for QC approval.
Step 7 After approval material is packed in required pack sizes.

Storage stability study-Methoxyfenozide 35% + Emamectin Benzoate 2% +Thiamethoxam 25% WG
Parameters Specification (In house) Initial Stability (for 14 days)
At 54±2 0C At 0±2 0C
Description Off white colour granules Complies Complies Complies
Methoxyfenozide content percent by mass 33.25 to 36.75 35.22 35.10 35.20
Emamectin Benzoate content percent by mass 1.9 to 2.2 2.15 2.06 2.14
Thiamethoxam content percent by mass 23.75 to 26.25 25.14 25.03 25.12
Methoxyfenozide suspensibility percent min. 70 96.62 95.22 96.61
Emamectin Benzoate suspensibility percent min. 70 98.55 96.05 97.95
Thiamethoxam suspensibility percent min. 70 97.45 95.35 97.26
pH range (1% aq. Suspension) 5.5 to7.5 7.2 7.0 7.1
Wettability sec. max. 60 8 10 9
Wet Sieve(45 micron ) percent by mass min. 98.5 99.5 99.3 99.5
Bulk density (g/ml) 0.45 to 0.75 0.53 0.53 0.53
Moisture content percent by mass max. Max. 2.0% 1.4 0.8 1

Room temperature storage data
Parameters Specification (In house) Study Duration
1 month 6 month 12 months 24 months
Description Off white colour granules Complies Complies Complies Complies
Methoxyfenozide content percent by mass 33.25 to 36.75 35.20 35.18 35.16 35.11
Emamectin Benzoate content percent by mass 1.9 to 2.2 2.14 2.13 2.11 2.08
Thiamethoxam content percent by mass 23.75 to 26.25 25.13 25.11 25.08 25.04
Methoxyfenozide suspensibility percent min. 70 96.45 96.37 96.28 95.29
Emamectin Benzoate suspensibility percent min. 70 98.11 98.05 97.86 96.31
Thiamethoxam suspensibility percent min. 70 97.38 97.26 96.65 95.88
pH range (1% aq. Suspension) 5.5 to7.5 7.2 7.2 7.1 7.0
Wettability sec. max. 60 8 9 9 10
Wet Sieve(45 micron ) percent by mass min. 98.5 99.5 99.5 99.5 99.4
Bulk density (g/ml) 0.45 to 0.75 0.53 0.53 0.53 0.53
Moisture content percent by mass max. Max. 2.0% 1.4 0.8 0.6 0.4

Example 8- Methoxyfenozide 17.5% + Emamectin benzoate 1%+ Thiamethoxam 12.5% SC
Chemical Composition Percent (% w/w)
Methoxyfenozide a.i. 17.5
Emamectin benzoate a.i. 1.0
Thiamethoxam a.i. 12.5
Acrylic graft copolymer 3.0
Polyalkoxylated Butyl Ether 2.0
Alkylated naphtalene sulfonate, sodium salt 0.5
Silicone antifoam 0.5
1,2-benzisothiazolin-3-one 0.20
Mono Ethylene Glycol 5.0
Polysaccharides 0.15
Water QS
TOTAL 100.0

Manufacturing Process Methoxyfenozide 17.5% + Emamectin benzoate 1%+ Thiamethoxam 12.5% Suspension Concentrate (SC) :
Step 1 Gum Solution should be made 12-18 hour prior to use. Take required quantity of water, biocide, and defoamer and homogenise, then slowly add gum powder to it and stir till complete dissolution.
Step 2 Charge required quantity of DM water need to be taken in designated vessel for Suspension concentrate production.
Step 3 Add required quantity of Wetting agent, anti-freezing, dispersing agent & suspending agents and homogenise the contents for 45 – 60 minutes using high shear homogeniser.
Step 4 Then add technical and other remaining adjuvants excluding ‘thickener’ are added to it and homogenised to get uniform slurry ready for grinding.
Step 5 Before grinding half the quantity of antifoam was added and then material was subjected to grinding in Dyno mill till desired particle size is achieved.
Step 6 Half quantity of the antifoam was added after grinding process completes and before sampling for in process analysis.
Step 7 Finally add gum solution to this formulation and send to QC for quality check.

Storage stability Study-Methoxyfenozide 17.5% + Emamectin benzoate 1%+ Thiamethoxam 12.5% SC
Parameters Specification (In house) Initial Stability (for 14 days)
At 54±2 0C At 0±2 0C
Description White colour flowable liquid Complies Complies Complies
Methoxyfenozide content percent by mass 16.625 to 18.375 17.57 17.53 17.57
Emamectin Benzoate content percent by mass 0.95 to 1.1 1.07 1.02 1.06
Thiamethoxam content percent by mass 11.875 to 13.125 12.62 12.54 12.61
Methoxyfenozide suspensibility percent mini. 80 98.14 96.02 97.65
Emamectin Benzoate suspensibility percent mini. 80 97.25 95.21 97.18
Thiamethoxam suspensibility percent mini. 80 98.88 96.05 98.85
pH range (1% aq. Suspension) 5.5 to7.5 7.13 7.11 7.13
Pourability 95 % min 98.70 97.70 97.60
Specific gravity 1.05 – 1.15 1.09 1.09 1.09
Viscosity at spindle no.62, 20 rpm 350 -800 cps 460 490 495
Particle size (micron) D50 <3, D90 <10 2.2, 7.9 2.6, 8.5 2.7, 8.5
Persistent foam ml (after 1 minute) max. 60 5 5 5

Room temperature storage data
Parameters Specification (In house) Study Duration
1 month 6 month 12 months 24 months
Description White colour flowable liquid Complies Complies Complies Complies
Methoxyfenozide content percent by mass 16.625 to 18.375 17.57 17.56 17.55 17.54
Emamectin Benzoate content percent by mass 0.95 to 1.1 1.07 1.06 1.05 1.03
Thiamethoxam content percent by mass 11.875 to 13.125 12.61 12.60 12.58 12.55
Methoxyfenozide suspensibility percent mini. 80 98.39 98.87 98.54 96.65
Emamectin Benzoate suspensibility percent mini. 80 97.75 97.68 97.15 96.45
Thiamethoxam suspensibility percent mini. 80 98.45 98.63 98..52 97.55
pH range (1% aq. Suspension) 5.5 to7.5 7.13 7.13 7.12 7.11
Pourability 95 % min 98.70 98.60 98.30 97.50
Specific gravity 1.05 – 1.15 1.09 1.09 1.09 1.09
Viscosity at spindle no.62, 20 rpm 350 -800 cps 460 465 470 485
Particle size (micron) D50 <3, D90 <10 2.2, 8 2.2, 8.1 2.3, 8.2 2.5, 8.5
Persistent foam ml (after 1 minute) max. 60 5 5 5 5

Further preferred formulations:

Following formulations may be prepared as per the procesees disclosed above:

ExNo. Active Ingredient I Active Ingredient II Active Ingredient III A.I.(%) in formulation Preferred Formulation type Formulation per Hectare (g or ml)
A.I. I A.I. II A.I. III
9 Methoxyfenozide Indoxacarb Bifenthrin 20.0% 7.5% 5.0% SC 1000
10 Methoxyfenozide Indoxacarb Bifenthrin 20.0% 7.5% 5.0% ZE 1000
11 Methoxyfenozide Indoxacarb Profenofos 14.0% 5.0% 20.0% EC 1250
12 Methoxyfenozide Indoxacarb Emamectin Benzoate 35.0% 12.0% 2.0% WG 500
13 Methoxyfenozide Emamectin Benzoate Bifenthrin 17.5% 1.0% 7.5% SC 1000
14 Methoxyfenozide Emamectin Benzoate Profenofos 17.5% 1.0% 30.0% EC 1000
15 Methoxyfenozide Emamectin Benzoate Thiamethoxam 35.0% 2.0% 25.0% WG 500
16 Methoxyfenozide Emamectin Benzoate Thiamethoxam 17.5% 1.0% 12.5% SC 1000

Example 17-Biological Examples:
The synergistic pesticide action of the inventive mixtures can be demonstrated by the experiments below. A synergistic effect exists wherever the action of a combination (ready-mix) of active ingredient is greater than the sum of the action of each of the components alone. Therefore a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticide activity than the sum of the pesticide activities of the individual components. In the field of agriculture, it is often understood that the term “synergy” is as defined by Colby S.R. in an article entitled “ Calculation of the synergistic and antagonistic responses of herbicide combinations” published in the journal Weeds, 1967, 15, p.20-22, incorporated herein by reference in its entirety. The action expected for a given combination of two active components can be calculated as follows:
Colby’s Formula:

To study the synergistic effect of combination of Methoxyfenozide, Indoxacarb and Bifenthrin, various sets of experiments were conducted in different crops like rice, tomato and chilli.
Example A: Synergism
The synergistic action of Methoxyfenozide+ Indoxacarb+ Bifenthrin, Methoxyfenozide+ Indoxacarb+ Emamectin benzoate, Methoxyfenozide+ Emamectin benzoate +Bifenthrin and Methoxyfenozide +Emamectin benzoate +Profenofos was studied by conducting Bioefficacy experiments on different crops.
Details of Experiment: Laboratory bio assay
a) Test Insects : Helicoverpa armiger (3rd Instar) Laboratory culture
b) Experiment design : Randomized Block Design
c) Replication : Four
d) Treatments : Twelve
e) Number of larvae per replication : 16 (One HIS tray with 16 cells)
a) Evaluation Method :
Cotton leaves collected from the farm (unsprayed plant) and cut in to 2x2 sq.cm.size. Such 48 cut pieces of cotton leaves, dip in desired solution of insecticides as per the details given. After dipping, it placed on tissue paper and allow to dry for 15 minutes. Each treated cut piece of cotton leave, placed in to each cell of HIS tray (16 cell stay) with moist filter paper. The 3rd instar larvae from laboratory reared culture were released. One larvae in each cell and it covered with plastic lead with ventilation hole. Such 3 HIS tray were taken as 3 replication per treatment. These Trays should be kept in incubator at 30 degree C temperature and 14 : 10 hrs L:D. Evaluation at 96 hrs after release for % mortality (dead + moribund) and % feeding. Larval mortality was calculated as below :
Number of dead larvae in treatment (out of 16)
% Larval mortality = ----------------------------------------------------------- X 100
Number of larvae treated (16)

If any larval mortality observed in untreated tray, the % corrected larval mortality should be calculated by below mention formula :
Henderson-Tilton's formula
Corrected % = (1 - n in Co before treatment * n in T after treatment

n in Co after treatment * n in T before treatment
) * 100
Where : n = Insect population , T = treated , Co = control

Table 1: Synergistic larval control of Helicoverpa armigera
Treatment details % Larval Control, Helicoverpa armigera
Observed Value Calculated Value Ratio
Methoxyfenozide+Indoxacarb+Bifenthrin-80+20+20 ppm 100 43.47 2.30
Methoxyfenozide+Indoxacarb+E.B.-80+20+10 ppm 100 49.49 2.02
Methoxyfenozide+Indoxacarb-80+20 ppm 38.86 39.98 0.97
Methoxyfenozide+Bifenthrin-80+20 ppm 28.6 29.23 0.98
Methoxyfenozide+E.B.-80+10 ppm 36.5 36.76 0.99
Indoxacarb+Bifenthrin-20+20 ppm 24.5 24.77 0.99
Indoxacarb+E.B.-20+10 ppm 30.68 32.77 0.94
Methoxyfenozide- 80 ppm 24.86
Indoxacarb- 20 ppm 20.12
Bifenthrin- 20 ppm 5.82
E. B.- 10 ppm 15.84
Untreated Check (UTC) 0.00
E.B. Emamectin Benzoate, ppm Parts per million

The laboratory bioassay of feeding test on Helicoverpa armigera shows that Methoxyfenozide +Indoxacarb +Bifenthrin and Methoxyfenozide +Indoxacarb +Emamectin benzoate shows synergism in terms of larval control compared to the other prior art treatments.

Example B - Residual larval control
The residual efficacy of synergistic combinations of Methoxyfenozide+ Indoxacarb+ Bifenthrin, Methoxyfenozide+ Indoxacarb+ Emamectin benzoate, Methoxyfenozide +Indoxacarb +Profenofos, Methoxyfenozide+ Emamectin benzoate +Bifenthrin and Methoxyfenozide +Emamectin benzoate +Profenofos were studied by conducting lab-field bioassay against diamond back moth, Plutella xylostella on cabbage crop.
Details of Experiment: A Lab.-field bioassay to study the residual control
a) Experiment design : Complete Block Design
(3 middle rows to be considered as 3 replications)
b) Treatments : Eight (including untreated check)
c) Plot size : 20 m2.
d) Spacing : 30 cm X 30 cm
e) Test Crop & Variety : Cabbage, Sutton Express
f) Spray method : CO2 Sprayer fitted with hollow cone nozzle (TXVS-4 green) Spray volume-500 liter per hectare

g) Evaluation Method: Immediately after spraying, wet (sprayed) leaves should be marked by clipping the tip with scissors. Treated leaves from each treatment should be collected at 1, 5, 10, 15 and 20 days after treatment. Collected leaves should be cut in to pieces of 1 sq inch and placed in HIS trays with moist filter paper. 2nd instar diamond backmoth (Plutella xylostella) larvae from lab culture to be used for experiment. One tray for each rep, so total 48 larvae per 3 reps per treatment. Trays should be kept in incubator at 26 degree C temperature and 14: 10 hrs L: D. Evaluation at 72 hrs after release for % mortality (dead + moribund) and % feeding. Larval mortality was calculated as below :

h)
Number of dead larvae in treated plot
% Larval mortality = ---------------------------------------------------- X 100
Number of dead larvae in untreated plot

Table 2: Residual larval control of Diamond back moth, Plutella xylostella
Treatments details Formulation (g or ml/h) Rate (g.a.i/h) % Larval Control
1 DAA 5 DAA 10 DAA 15 DAA 20 DAA
Methoxyfenozide 20%+Indoxacarb 7.5% + Bifenthrin 5% SC 1000 200+75+50 100.00 99.92 96.64 90.64 80.42
Methoxyfenozide 35% + Indoxacarb 12% + Emamectin Benzoate 2% WG 500 175+60+10 100.00 98.84 96.10 89.60 75.62
Methoxyfenozide 14% + Indoxacarb 5% + Profenofos 20% WG 1250 175+62.5+250 100.00 98.64 95.82 88.46 76.82
Methoxyfenozide 17.5% + Emamectin benzoate 1% + Bifenthrin 7.5% SC 1000 175+10+75 100.00 98.10 95.24 88.36 74.24
Methoxyfenozide 17.5% + Emamectin benzoate 1% + Profenofos 30% EC 1000 175+10+300 100.00 98.82 96.32 89.64 77.64
Methoxyfenozide 20% + Indoxacarb 7.5% SC 1000 200+75 92.84 80.74 68.58 30.64 16.86
Methoxyfenozide 17.5% + Emamectin benzoate 1% SC 1000 175+10 90.28 78.88 65.92 28.60 14.52
Methoxyfenozide 20% + Bifenthrin 5% SC 1000 200+50 80.26 70.82 52.84 18.64 0.00
Methoxyfenozide 14% + Profenofos 20% WG 1250 175+250 77.52 65.38 46.26 12.60 0.00
Indoxacarb 7.5% + Bifenthrin 5% SC 1000 75+60 75.84 62.30 40.12 8.64 0.00
Emamectin benzoate 2% + Indoxacarb 12% WG 500 10+60 89.16 76.40 64.78 22.68 12.2
Emamectin benzoate 1% + Bifenthrin 7.5% SC 1000 10+75 70.48 58.82 38.64 11.62 0.00
Emamectin benzoate 1% + Profenofos 30% EC 1000 10+300 68.74 53.44 32.64 0.00 0.00
Methoxyfenozide 20% SC 1000 200 58.48 31.76 10.82 0.00 0.00
Indoxacarb 7.5% SC 1000 75 52.38 28.92 6.48 0.00 0.00
Emamectin benzoate 2% WG 500 10 43.60 24.38 8.36 0.00 0.00
Bifenthrin 7.5% SC 1000 75 38.16 18.48 0.00 0.00 0.00
Profenofos 30% EC 1000 300 40.36 20.38 2.68 0.00 0.00
Untreated Check (Water spray) 0 0 0.00 0.00 0.00 0.00 0.00
SC Suspension Concentrate, WG Water Dispersible Granules, EC Emulsifiable Concentrate.

The test result of a lab field bioassay shows the excellent residual efficacy of synergistic combinations of Methoxyfenozide+ Indoxacarb+ Bifenthrin, Methoxyfenozide+ Indoxacarb+ Emamectin benzoate, Methoxyfenozide +Indoxacarb +Profenofos, Methoxyfenozide+ Emamectin benzoate +Bifenthrin and Methoxyfenozide +Emamectin benzoate +Profenofos against larvae of Diamond back moth Plutella xylostella compared to all the prior art treatments, which ultimately helps the farmer to reduce the number of sprays and there by reducing the active ingredient loading in to the environment.
,CLAIMS:We claim;
[CLAIM 1]. A pesticidal composition comprises A) Methoxyfenozide B) at least one insecticide selected from Indoxacarb and Emamectin Benzoate C) at least one more insecticide selected from Bifenthrin, Cypermethrin, Deltamethrin, Fenpropathrin, Lambda cyhalotrhin, Acephate, Chlorpyrifos, Profenofos, Quinalphos, Triazophos, Acetamiprid, Clothianidin, Imidacloprid, Thiamethoxam, Novaluron, Lufenuron, Chlorfluazuron, Pyriproxyfen, Chlorantraniliprole, Cyantraniliprole, Flubendiamide, Abamectin, Spinetoram, Spinosad, Chlorfenapyr, Diafenthiuron, Fipronil, Pyridalyl and Tolfenpyrad.

[CLAIM 2]. A pesticidal composition composition as claimed in claim 1 wherein most preferred composition are selected from:
a) Methoxyfenozide : Indoxacarb : Bifenthrin;
b) Methoxyfenozide : Indoxacarb : Profenofos
c) Methoxyfenozide : Emamectin Benzoate :Bifenthrin
d) Methoxyfenozide : Emamectin Benzoate : Profenofos
e) Methoxyfenozide : Emamectin Benzoate : Thiamethoxam

[CLAIM 3]. A pesticidal composition composition as claimed in claim 1 wherein
I. A) Methoxyfenozide is in range of 0.1-40%;
II. B) at least one insecticide selected from Indoxacarb and Emamectin Benzoate is in range of 0.1-20%; and
III. C) at least one more insecticide selected from Bifenthrin, Cypermethrin, Deltamethrin, Fenpropathrin, Lambda cyhalotrhin, Acephate, Chlorpyrifos, Profenofos, Quinalphos, Triazophos, Acetamiprid, Clothianidin, Imidacloprid, Thiamethoxam, Novaluron, Lufenuron, Chlorfluazuron, Pyriproxyfen, Chlorantraniliprole, Cyantraniliprole, Flubendiamide, Abamectin, Spinetoram, Spinosad, Chlorfenapyr, Diafenthiuron, Fipronil, Pyridalyl and Tolfenpyrad is in range of 0.1-40%.

[CLAIM 4]. A pesticidal composition composition as claimed in claim 1 or 2, wherein inactive excipients are selected from the group consisting of dispersant, anti-freezing agent, anti-foam agent, wetting agent, suspension aid, anti-microbial agent, thickener, quick coating agent or sticking agents and buffering agent.

[CLAIM 5]. A pesticidal composition composition as claimed in claim 1 -4, wherein the composition are selected from formulations comprising of dustable powder (DP), a gel, a wettable powder (WP), a granule (GR) (such as an emulsifiable granule (EG) or more particularly a water-dispersible granule (WG)), a water-dispersible tablet (WT), an emulsifiable concentrate (EC), a micro- emulsifiable concentrate, an oil-in-water emulsion (EW), an oil flowable ( a spreading oil (SO)), an aqueous dispersion (aqueous suspension concentrate (SC)), an oily dispersion (OD), a suspo-emulsion (SE), a capsule suspension (CS), a soluble liquid, a water-soluble concentrate (with water or a water-miscible organic solvent as carrier), ZE formulation .

[CLAIM 6]. A pesticidal composition composition as claimed in claim 5, wherein the preferable formulations are suspension concentrate (SC), emulsifiable concentrate (EC), Water Dispersible Granules (WG), ZE formulation (ZE).

[CLAIM 7]. A pesticidal composition composition as claimed in claim 6, wherein suspension concentrate (SC) formulation comprises:
a) Methoxyfenozide in range of 0.1-40%;
b) at least one insecticide selected from Indoxacarb and Emamectin Benzoate in range of 0.1-20%;
c) at least one more insecticide selected from Bifenthrin, Cypermethrin, Deltamethrin, Fenpropathrin, Lambda cyhalotrhin, Acephate, Chlorpyrifos, Profenofos, Quinalphos, Triazophos, Acetamiprid, Clothianidin, Imidacloprid, Thiamethoxam, Novaluron, Lufenuron, Chlorfluazuron, Pyriproxyfen, Chlorantraniliprole, Cyantraniliprole, Flubendiamide, Abamectin, Spinetoram, Spinosad, Chlorfenapyr, Diafenthiuron, Fipronil, Pyridalyl and Tolfenpyrad in range of 0.1-40% ;
d) Wetting agent and Spreader as Trisiloxane ethoxylate;
e) Filler, Absorbent, Emulsifier, Dispersants & Stabilizers, Anti-caking and Free-flow agent.

[CLAIM 8]. A pesticidal composition composition as claimed in claim in any of the preceding claims, wherein the said composition effective amount is from about 500 grams / ml of pesticidal composition per hectare to about 1250 grams / ml of pesticidal composition per hectare

[CLAIM 9]. A pesticidal composition composition as claimed in claim in any of the preceding claims, wherein the said composition is used for effective control of Insect-pests in Cotton (Gossypium spp.), Jute (Corchorus oliotorus), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Ragi (Eleusine coracana), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum) , Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus) , Mustard (Brassica juncea), Rape seed (Brassica napus), Linseed (Linum usitatissimum), Sesame (Sesamum indicum), Castor (Ricinus communis), Green gram (Vigna radiate), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa subsp rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Litchi (Litchi chinensis), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum) , Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum), Ajwain (Trachyspermum ammi), Psyllium (Plantago ovate), Black Pepper (Piper nigrum), Stevia (Stevia rebaudiana), Safed musli (Chlorophytum tuberosum), Drum stick (Moringa oleifera), Coconut (Coco nucifera), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold ( Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera ( Gerbera jamesonii), Carnation (Dianthus caryophyllus)

[CLAIM 10]. A pesticidal composition composition as claimed in in any preceding claims, wherein the composition is used for effective control of pests and insects Agrotis ypsilon, Alabama argillacea, Anticarsia gemmatalis, Cacoecia murinana, Capua reticulana, Chilo partellus, Chilo suppressalis, Choristoneura fumiferana, Choristoneura occidentalis, Cirphis unipuncta, Cnaphalocrocis medinalis, Cydia pomonella, Diatraea saccharalis, Dendrolimus pini, Diaphania nitidalis, Earias vittella, Earias insulana, Elasmopalpus lignosellus, Eupoecilia ambiguella, Evetria bou-liana, Exelastis atomosa, Feltia subterranea, Galleria mellonella, Grapholitha funebrana, Helicoverpa armigera, Helicoverpa virescens, Helicoverpa zea, Hellula undalis, Hibernia defoliaria, Hyphantria cunea, Hyponomeuta malinellus, Keiferia lycopersicella, Laphygma exigua, Leucinodes orbonalis, Leucoptera coffeella, Leucoptera scitella, Lithocol-letis blancardella, Lobesia botrana, Loxostege sticticalis, Lymantria dispar, Lymantria monacha, Lyonetia clerkella, Malacosoma neustria, Mamestra brassicae, Marasmia pantalis, Maruca vitrata, Maruca testulalis, Mythimna separata, Orgyia pseu-dotsugata, Ostrinia nubilalis, Panolis flammea, Pectinophora gossypiella, Peridroma saucia, Phalera bucephala, Phthorimaea operculella, Phyllocnistis citrella, Pieris bras-sicae, Plathypena scabra, Plutella xylostella, Pseudoplusia includens, Rhyacionia frus-trana, Scirpophaga incertulas, Scirpophaga innotata, Scrobipalpula absoluta, Sesamia inferens, Sitotroga cerealella, Sparganothis pilleriana, Spilosoma obliqua, Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Thaumatopoea pityocampa, Tortrix viridana, Trichoplusia ni, Tuta absolutaand Zeiraphera Canadensis.