DESC:FIELD OF THE INVENTION:

The present invention relates to pesticidal composition comprising of an Anthranilamide and at least one fungicide. The present invention also relates to the method of preparing the said composition, wherein Anthranilamide may be selected from Chlorantraniliprole or Flubendiamide and fungicide is selected from Azoxystrobin, Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole, and Prothioconazole with the proviso that Azoxystrobin will not be combined with Chlorantraniliprole. The present invention also provides a method of controlling or preventing pathogenic damage or pest damage in a plant propagation material, a plant, parts of a plant and/or plant organs that grow at a later point in time with the use of pesticidal composition of present invention.

BACKGROUND OF THE INVENTION

Anthranilic diamides, alternatively called anthranilamides, are a recently discovered class of insecticides having activity against numerous insect pests of economic importance. PCT Publication WO 2003/024222 discloses treatment with anthranilic diamides being useful for protecting propagules from phytophagous invertebrate pests. Furthermore, because of the ability of anthranilic diamides to translocate within plants, not only the propagules, but also new growth developing from the propagules can be protected.

Although anthranilic diamides have properties making them suitable for protecting propagules and developing growth, achieving sufficient absorption of anthranilic diamides into the propagule and developing roots to cause insecticidally effective concentrations in parts of the developing plant for which protection is desired can be problematical. Although anthranilic diamide coatings on propagules are exposed to moisture from the propagules and surrounding plant growing medium (e.g., soil), the low water solubility of anthranilic diamide insecticides impedes their mobilization through moisture. Also, until the anthranilic diamides are absorbed into the propagules and developing roots, they are vulnerable to absorption and dissipation through the growing medium.

Achieving insecticidally effective concentrations of anthranilic diamides in foliage by treating propagules requires greater amounts of anthranilic diamide to be available for transport greater distances within the plant. Because the rapidly expanding volume of plant tissue in growing foliage inherently dilutes anthranilic diamide concentrations, absorption of increased amounts of anthranilic diamide is required for protection of foliage, particularly if protection of foliage beyond the first couple leaves and during a substantial part of the growing season is desired.

Fungi serve as the planet's decomposers by breaking down organic material in nature, while many form healthy symbiotic relationships with plants in the soil. Unfortunately some fungi develop parasitic relationships with plants where the plant is harmed making it important to have the proper fungicide to minimize those effects.

Fungi are plants which obtain their nutrition from an organic carbon source. The body of the fungus secretes enzymes which degrade the organic substrate on which they are growing and yield smaller entities. These in turn are absorbed into the body of the fungus and are metabolized and provide energy to carry on vital processes.

Fungicides can either be contact, translaminar or systemic. Contact fungicides are not taken up into the plant tissue, and protect only the plant where the spray is deposited; translaminar fungicides redistribute the fungicide from the upper, sprayed leaf surface to the lower, unsprayed surface; systemic fungicides are taken up and redistributed through the xylem vessels. Few fungicides move to all parts of a plant. Some are locally systemic, and some move upwardly.

Fungicides also can be classified based upon their chemical composition. Chemically, organic molecules are those that contain carbon atoms in their structure whereas inorganic molecules do not. Many of the first fungicides developed were inorganic compounds based on sulfur or metal ions such as copper, tin, cadmium and mercury that are toxic to fungi. Copper and sulfur are still widely used. Most other fungicides used today are organic compounds and thus contain carbon. The term "organic" as used here is based on chemistry terminology and differs from "organic" used to describe a system of agriculture that strives to be holistic and to enhance agro ecosystem health.

Fungicides kill fungi by damaging their cell membranes, inactivating critical enzymes or proteins, or by interfering with key processes such as energy production or respiration. Others impact specific metabolic pathways such as the production of sterols or chitin. In recent developments, the newly developed fungicides are unique in that they do not directly affect the pathogen itself. Many of new fungicides elicit a response from the host plant known as "systemic acquired resistance" (SAR). These SAR inducers basically mimic chemical signals in plants that activate plant defense mechanisms such as the production of thicker cell walls and anti-fungal proteins. The utility of SAR inducers, however, has been limited so far since many pathogens are capable of over-powering such defenses.

Fungicide resistance is a stable, heritable trait that results in a reduction in sensitivity to a fungicide by an individual fungus. This ability is obtained through evolutionary processes. Fungicides with single-site mode of action are at relatively high risk for resistance development compared to those with multi-side mode of action. Most fungicides being developed today have a single-site mode of action because this is associated with lower potential for negative impact on the environment, including non-target organisms.

When fungicide resistance results from modification of a single major gene, pathogen subpopulations are either sensitive or highly resistant to the pesticide. Resistance in this case is seen as complete loss of disease control that cannot be regained by using higher rates or more frequent fungicide applications. This type of resistance is commonly referred to as "qualitative resistance."

The control of phytopathogenic fungi is of great economic importance since fungal growth on plants or on parts of plants inhibits production of foliage, fruit or seed, and the overall quality of a cultivated crop.

Flubendiamide was first disclosed in US6603044 and IN 225112. Flubendiamide is known as3-iodo-N'-(2-mesyl-1,1-dimethylethyl)-N-{4-[1,2,2,2-tetrafluoro-1-trifluoromethyl) ethyl] -o-tolyl} phthalamide.

Chlorantraniliprole was first disclosed WO 03/015518. Chlorantraniliprole is chemically known as 3-bromo-4'-chloro-1-(3-chloro-2-pyridyl)-2'-methyl-6'-(methylcarbamoyl) pyrazole-5-carboxanilide. Chlorantraniliprole has efficient mechanism which is activated by ryanodine receptor, excessive release of intracellular stores of calcium ions, resulting in the death of the insect paralysis. Chlorantraniliprole is efficient broad-spectrum, for the purpose of Noctuidae phosphorus wing, bore fruit moth, leaf roller Branch, flour moth and other mouth Coleoptera Curculionidae, Chrysomelidae, Diptera Agromyzidae etc. are good control effect.

Difenoconazole was first disclosed in GB 2098607. Difenoconazole is chemically known as 1-[[2-[2-Chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole.

Flusilazole was first disclosed in US 4510136. Flusilazole is chemically known as 1-[[Bis(4-fluorophenyl)methylsilyl]methyl]-1H-1,2,4-triazole.

Cyproconazole was first disclosed in US 4664696. Cyproconazole is chemically known as a-(4-Chlorophenyl)- a -(1-cyclopropylethyl)-1H-1,2,4-triazole-1-ethanol.

Epoxiconazole was first disclosed in US 4906652. Epoxiconazole is chemically known as rel-1-[[(2R,3S)-3-(2-Chlorophenyl)-2-(4-fluorophenyl)oxiranyl]methyl]-1H-1,2,4-triazole.

Azoxystrobin was first disclosed in US 5395837. Azoxystrobin is chemically known as (aE)-2-[[6-(2-Cyanophenoxy) -4-pyrimidinyl]oxy]-a-(methoxymethylene) benzeneacetic acid methyl ester.

Prothioconazole was first disclosed in US 5789430. Prothioconazole is chemically known as 2-[2-(1-Chlorocyclopropyl) -3-(2-chlorophenyl)-2-hydroxypropyl] -1,2-dihydro-3H-1,2,4-triazole-3-thione.

The main concern with the use of insecticide and/or fungicide is the development of resistance by the insects for that particular insecticide and at the end one has to apply more concentrated formulation of the insecticide and/or fungicide. The high amount of insecticide and/or fungicide may results in the toxicity to human beings as well as has bad effect on environment.

Previously people have tried many alternatives and option to overcome this problem and as a result developed poly mixture of insecticide, use of non-toxic ingredients and developing novel formulations which provides effective amount of the insecticide and/or fungicide and at the required part only. However the use of poly mixture containing large number of insecticide and/or fungicide poses a problem in many was like preparing formulation of multiple insecticide and/or fungicide with different chemical properties and behavior and physical properties. It also creates challenge for the formulator in term of compatibility and stability of all the insecticides along with the used excipients in the formulation.

US20100310518 discloses a composition comprising Flubendiamide and at least one beneficial species selected from the group consisting of predatory mites, nematodes, fungi, bacteria, virus strains, Araneae, Acari, Dermaptera, Hymenoptera, Coleoptera, Neuroptera, Thysanoptera, Heteroptera, Diptera, Hemiptera, DermapteraParasitiformes, and Plannipennia.

CN103461333 describes a pesticide composition containing flubendiamide and methoxyfenozide. The pesticide composition is effective for preventing and controlling pests. The pesticide composition is characterized by comprising active constituents, namely flubendiamide and methoxyfenozide, wherein the weight ratio of the flubendiamide to the methoxyfenozide is (50 to 1) to (1 to 50). According to the pesticide composition containing the flubendiamide and the methoxyfenozide, the flubendiamide and the methoxyfenozide are combined for effectively preventing or controlling the pests. The pest control activity of the combination of the active constituents is greatly higher than the total performance of single active constituents, and the pesticide composition has a real synergistic effect.

CN102318611 discloses a synergistic insecticidal composition which is a mixture of a compound (A) Flubendiamide and a compound (B) Chlorantraniliprole. The insecticidal composition can be processed in missible oils, suspending agents, wettable powders and water dispersible granules. The weight ratio of the compound (A) flubendiamide to the compound (B) chlorantraniliprole is (1-100) :( 1-100). The insecticidal composition is high in insecticidal efficiency and can be used for preventing and treating various injurious insects on various crops such as rice, cottons, vegetables and the like effectively. The preventing and treating efficiency of the synergistic insecticidal composition is superior to that obtained by independently using the compound (A) flubendiamide or the compound (B) chlorantraniliprole, and the dosage of each active material can be reduced greatly. The insecticidal composition has not only ecological meanings but also important environmentally-friendly meanings.

CN104872171 mentions a paddy field composite bactericide containing flutriafol, isoprothiolane and flusilazole, and the application thereof. The bactericide comprises three main effective ingredients, namely flutriafol, isoprothiolane and flusilazole in the mass ratio of 0.1-20:0.1-30:0.1-15 correspondingly. Based on a large number of special researches, the inventor of the invention mixes flutriafol, isoprothiolane and flusilazole in a suitable ratio to successfully play the advantages of the three effective ingredients to the limit. Meanwhile, the comprehensive prevention and control defects of a single-dosage bactericide to crop diseases, such as banded sclerotial blight, rice blast, bakanae disease and the like, can be overcome.

CN104642376 discloses a bactericidal composition containing prothioconazole and flusilazole and application thereof. The bactericidal composition uses prothioconazole and flusilazole as the main effective components. The insecticidal composition can be applied to control of diseases of cereal, fruit tree and vegetables, has high synergetic effects and overcomes and delays pathogen resistance; the bactericidal composition has the advantages of high insecticidal speed, long effective period, reduced application cost and control effect obvious better than that of single dose usage.

US8101772 relates to novel active compound combinations comprising a known oxime ether derivative (trifloxystrobin) and imidacloprid, which combinations are highly suitable for controlling phytopathogenic fungi and insects.

However, the biological properties of these mixtures of known compounds are not completely satisfactory in the field of pest control.

In general use, the pesticide actives are used in the form of a dilute aqueous composition because it can attain a good interaction with the target organism, such as plants, fungi and insects. However, most active pesticide compounds that are used as pesticides are only sparingly or even insoluble in water. The low solubility of such compounds present the challenges and difficulties to formulator in formulating pesticide compounds in stable formulations that can be easily stored for a long time and which still have a high stability and effective activity until end use.

For the reasons mentioned above there does a need to provide further formulation of combinations comprising Chlorantraniliprole or Flubendiamide and fungicide is selected from Azoxystrobin, Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole, and Prothioconazole with the proviso that Azoxystrobin will not be combined with Chlorantraniliprole This object is achieved according to the invention by providing the present formulation.

SUMMARY OF THE INVENTION

Accordingly, in a first aspect, the present invention provides a pesticidal composition comprising an Anthranilamide selected from Flubendiamide or Chlorantraniliprole and at least one fungicide, wherein fungicide can be selected from Azoxystrobin, Difenoconazole, Flusilazole, Cyproconazole, Prothioconazole and Epoxiconazole and one or more inactive excipients, with the proviso that Azoxystrobin will not be combined with Chlorantraniliprole.

Accordingly, in a second aspect, the present invention provides a method of controlling or preventing pathogenic damage or pest damage in a plant propagation material, a plant, parts of a plant and/or plant organs that grow at a later point in time, which comprises applying on the plant propagation material a composition comprising a formulated mixture defined in the first aspect.

According to another aspect of the present invention there is provided a composition comprising Anthranilamide selected from Flubendiamide or Chlorantraniliprole and at least one fungicide, wherein fungicide can be selected from Azoxystrobin, Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole and Prothioconazole in a specified % weight of the total formulation and at least one or more adjuvants.

According to another aspect of the present invention is disclosed composition comprising Anthranilamide selected from Flubendiamide or Chlorantraniliprole and at least one fungicide, wherein fungicide can be selected from Azoxystrobin, Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole and Prothioconazole in any of the form selected from wettable powder (WP), Water dispersible granules (WG/WDG), soil applied granules (SAG), dustable powder (DP), a gel, a wettable powder (WP), a granule (GR) (such as an emulsifiable granule (EG) or more particularly a water-dispersible granule (WG)), a water-dispersible tablet (WT), an emulsifiable concentrate (EC), a micro- emulsifiable concentrate, an oil-in-water emulsion (EW), an oil flowable (e.g. a spreading oil (SO)), an aqueous dispersion (e.g. aqueous suspension concentrate (SC)), an oily dispersion (OD), a suspo-emulsion (SE), a capsule suspension (CS), a soluble liquid, a water-soluble concentrate (with water or a water-miscible organic solvent as carrier), an impregnated polymer film, Flowable Slurry (FS) / Flowable Suspension(FS) / Suspension Concentrate (SC), Water dispersible powder for slurry seed treatment (WS), ZC ( A mixed formulation of CS and SC), ZE (A mixed heterogeneous formulation of CS and SE), ZW( A mixed heterogeneous formulation CS and EW) having synergistic effect.

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides synergistic insecticidal compositions comprising anthranilic diamide insecticides and at least one fungicide, wherein anthranilic diamide insecticide is Flubendiamide or Chlorantraniliprole; and fungicide is selected from Azoxystrobin, Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole and Prothioconazole with at least one inactive excipient with the proviso that Azoxystrobin will not be combined with Chlorantraniliprole.

The term “pesticide” or “pesticidal” is similar to “insecticide” or “insecticidal” and used interchangeably in this whole specification.
The term “formulation” and “composition” as used herein conveys the same meaning and can be used inter changeably.

Synergism is the cooperative action encountered in combinations of two or more biologically active compounds in which the combined activity of the two compounds exceeds the sum of the activities of the compounds when used alone.

The present invention provides inclusion complexes of anthranilic diamide insecticides with at least one fungicide, wherein fungicide can be selected from Azoxystrobin, Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole and Prothioconazole, a process for their preparation and the use thereof. In order to improve water-solubility of the anthranilic diamide insecticides, they are complexed with fungicide to prepare various solid and liquid formulations. Accordingly, the active ingredient anthranilic diamide insecticide in the form of an inclusion complex can be directly applied in solid or liquid dosage forms.

Anthranilic diamide insecticides, also known as Anthranilamide insecticides, are members of a class of insecticidal compounds characterized chemically by molecular structures comprising vicinal carboxamide substituents bonded to the carbon atoms of an aryl ring, typically phenyl, wherein one carboxamide moiety is bonded through the carbonyl carbon and the other carboxamide moiety is bonded through the nitrogen atom and characterized biologically by binding to ryanodine receptors in insect muscle cells, causing the channel to open and release calcium ions into the cytoplasm. Depletion of calcium ion stores results in insect paralysis and death. Anthranilic diamide insecticides are selected from Flubendiamide or Chlorantraniliprole.

The pesticidal or insecticidal formulations can be classified as below:
Dry – Sprayable: WP – Wettable powders: A solid pesticide formulation – micronized to powder form and typically applied as suspended particles after dispersion in water. WG or WDG – Water dispersible granule: A pesticidal formulation consisting of granules to be applied after disintegration and dispersion in water. Water dispersible granules can be formed by a) agglomeration, b) spray drying, or c) extrusion techniques.
Liquid Sprayable: SL – Soluble Concentrate: soluble concentrate is in powder form intended for dilution with water or directly in solution from. In both the case, the end result will be clear solution of the insecticide in the water without any visible un-dissolved particles. SC – Suspension Concentrate: A stable suspension of solid pesticide(s) in a fluid usually intended for dilution with water before use. For a good formulation or ideal SC formulation, it should be stable and do not sediment over time. EC – Emulsifiable Concentrate: A solution of a pesticide with emulsifying agents in a water insoluble organic solvent which will form an emulsion when added to water. In most of the case it is oil in water type emulsion to make it easy for application. EC formulation should be storage stable without any visible cracking of emulsion. ME – Microemulsion: A solution of a pesticide with emulsifying agents in a water insoluble organic solvent which will form a solution/emulsion when added to water. The difference between EC and ME is the particle size of the actives in the final form. OD – Oil dispersions (OD) are one type of liquid formulation which is stable suspensions of active ingredients in a water-immiscible fluid which may contain other dissolved active ingredients and is intended for dilution with water before use. CS – Capsule Suspension of micro-encapsulated active ingredient in an aqueous continuous phase, intended for dilution with water before use. SE- Suspension emulsion or suspo emulsion (SE) consists of an organic phase with a dissolved active ingredient and an aqueous suspension phase, in which the active ingredient is dispersed in water.

Dry – Spreadable Granule Dry spreadable granules are dry granules which can be applied with a dry spreader to a target area and later when such granules get exposed to water via, for example, rain or irrigation, will not only readily disintegrate, but actively spread on solid substrates so as to achieve disintegration area diameter to original granule diameter ratios. Dry spreadable granules should possess good hardness and an ability to maintain integrity upon normal, commercial handling in a dry spreading operation and yet be capable of quickly disintegrating or scattering upon what may be a minimal exposure to water, such as, for example, a light rain.
d) GR – Soil applied Granule on inert or fertilizer carrier this formulation is in the form of granules which can be applied on inert carrier or the carrier which is fertilizer.
Mixed formulation ZC Formulation (Mix of CS and SC): “ZC formulation” is the international denominations adopted by the FAO (Food and Agricultural Organization of the United Nations) to designate "stable aqueous suspension of microcapsules and solid fine particles". ZC is a mixed formulation of CS and SC and is a stable aqueous suspension of microcapsules and solid fine particles, each of which contains one or more active ingredients. The formulation is intended for dilution into water prior to spray application. Formulating the active ingredients together eliminates the need for tank mixing, which can lead to incompatibility, and facilitates control of a wider range of pests with fewer applications. Like other aqueous liquid formulations, ZC formulations are easy to handle and measure, dust free, non-flammable and offer good miscibility with water.

One or more of the active ingredients is encapsulated for various purposes, such as to increase the residual biological activity, or to reduce the acute toxicity, or to obtain a physical or chemically stable water-based formulation. The purpose determines whether the “free” active ingredient and the “release rate” are relevant properties of a specific product.

This invention relates to a composition for protecting plants, economically important crops. The present invention relates to plant-protecting active ingredient mixtures having synergistically enhanced action and to a method of improving the health of plants by applying said mixtures to the plants or the locus thereof. One typical problem arising in the Field of pest control lies in the need to reduce the dosage rates of the active ingredient in order to reduce or avoid unfavorable environmental or toxicological effects whilst still allowing effective pest and pathogen control.

Another problem encountered concerns the need to have available pest control agents which are effective against a broad spectrum of pests and pathogens.

Another problem underlying the present invention is the desire for compositions that improve plants, a process which is commonly and hereinafter referred to as “plant health”. For example, advantageous properties that may be mentioned are improved crop characteristics including: emergence, crop yields, protein content, more developed root system (improved root growth), tilering increase, increase in plant height, bigger leaf blade, less dead basal leaves, stronger tillers, greener leaf color, pigment content, photosynthetic activity, less fertilizers needed, less seeds needed, more productive tillers, earlier lowering, early grain maturity, less plant verse (lodging), increased shoot growth, enhanced plant vigor, increased plant stand and early germination; or any other advantages familiar to a person skilled in the art.

Advantageous invention relates to a composition of Anthranilamide selected from Flubendiamide or Chlorantraniliprole and at least one fungicide, wherein fungicide can be selected from Azoxystrobin, Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole and Prothioconazole in ratios by weight of the active ingredients are 1:10 to 10:1 with the proviso that Azoxystrobin is not combined with Chlorantraniliprole.

The novel active ingredient mixtures have very advantageous curative, preventive and systemic pesticidal properties for protecting cultivated plants. As has been mentioned, said active ingredient mixtures can be used to inhibit or destroy the pathogens that occur on plants or parts of plants (fruit, blossoms, leaves, stems, tubers, roots) of different crops or useful plants, while at the same time those parts of plants which grow later are also protected from attack by such pathogens. Active ingredient mixtures have the special advantage of being highly active against diseases in the soil that mostly occur in the early stages of plant development.

The term "health of a plant" or "plant health" is defined as a condition of the plant and/or its products. As a result of the improved health, yield, plant vigor, quality and tolerance to abiotic or biotic stress are increased. Noteworthy, the health of a plant when applying the method according to the invention, is increased independently of the pesticidal properties of the active ingredients used because the increase in health is not based upon the reduced pest pressure but instead on complex physiological and metabolic reactions which result for example in an activation of the plant's own natural defense system. As a result, the health of a plant is increased even in the absence of pest pressure.

The improvement of the plant vigor according to the present invention particularly means that the improvement of any one or several or all of the above mentioned plant characteristics are improved independently of the pesticidal action of the mixture or active ingredients (components).Another indicator for the condition of the plant is the "quality" of a plant and/or its products.

The list of crops which can be suitable for protection by the present composition are Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Maize (Zea mays), Sorghum (Sorghum bicolor), Sugarcane (Saccharum officinarum) , Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus) , Green gram (Vigna radiate), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Chilly (Capsicum annum), Apple (Melus domestica), Grape (Vitis vinifera), Pomegranate (Punica granatum),Tea (Camellia sinensis) and its GMO derivatives.

The composition of the present invention can be used to control insect pests from the following orders: from the order of the lepidopterans (Lepidoptera), for example Agrotis ypsilon, Cnaphalocrocis medinalis, Cydia pomonella, Earias vittella, Heliothis armigera, Hellula undalis, Pectinophora gossypiella, Pieris bras-sicae, Plutella xylostella, Scirpophaga incertulas, Sesamia inferens, Chilo suppressalis, Chilo partellus, Chilo infescatellus, Sitotroga cerealella, Maruca spp., Leucinoides orbonalis, Spodoptera exigua, Spodoptera litura, Trichoplusia ni, beetles, (Coleoptera), Anthonomus grandis, Diabrotica semipunctata, Epila-chna varivestis, Leptinotarsa decemlineata, Melanotus communis, Melolontha hippocastani, Phyllotreta chrysocephala, Popillia japonica, flies, mosquitoes (Diptera), e.g. Liriomyza sativae, Liriomyza trifolii, ants, bees, wasps, sawflies (Hymenoptera), Athalia lugen proxima. Plant parasitic nematodes such as root-knot nematodes, Meloidogyne incognita, Meloidogyne javanica and other Meloidogyne species; cyst nematodes, Globodera rostochiensis, and other Globodera species, Heterodera avenae, and other Heterodera species.

The composition of the present invention can be used to control fungal diseases like Wheat - Tilletia tritici, Neovossia indica, Puccinia triticina, Puccinia recondite, Erysiphe graminis, Blumeria graminis. Rice- Pyricularia oryzae, Ustilaginoidea virens, Rhizoctonia solani, Sclerotium rolfsii, Rhizoctonia solani, Maize : Anthracnose leaf blight, ear and kernel rot, Aspergillus flavus, Aspergillus niger, Fusarium kernel, root and stalk rot, seed rot and seedling blight Fusarium moniliforme, Peanut : Aspergillus crown rot Aspergillus niger, Cercospora arachidicola, Cercosporidium personatum, Rust Puccinia arachidis, Sclerotinia blight Sclerotinia minor, Sunflower- Alternaria leaf blight, stem spot and head rot Alternaria alternate, Cotton- Areolate mildew Ramularia gossypii, Boll rot Ascochyta gossypii , Colletotrichum gossypii, Leaf spot Alternaria macrospora, Capsicum spp -Anthracnose Colletotrichum gloeosporioides, C. capsici, Glomerella cingulata, Cercospora (frogeye) leaf spot Cercospora capsici, Damping-off and root rot Rhizoctonia solani, Phytophthora spp., Fusarium spp., Pythium spp., Powdery mildew Oidiopsis sicula, Leveillula taurica, Potato- Alternaria solani, Botrytis cinerea, Phytophthora infestans, Tomato- Alternaria alternate f. sp. Lycopersici, Phytophthora capsici, Stemphylium botryosum f. sp. Lycopersici, Phytophthora infestans, Apple- Aternaria mali, Venturia inaequalis, Marssonina blotch, Grape- Botrytis cinerea, Plasmopara viticola, Uncinula necator.

The composition of the present invention can be used to control Rice Diseases: Sheath blight (Rhizoctoniasolani), Blast (Pyriculariaoryzae), Helminthosporium leaf spot, Bakanae disease (Gibberellafujikuroi). Wheat diseases: powdery mildew (Erysiphegraminis), Fusarium head blight (Fusariumgraminearum), rust (Pucciniastriiformis, Pucciniagraminis, Pucciniarecondita), loose smut (Ustilagotritici), eye spot disease (Pseudocercosporellaherpotrichoides), leaf blight (Mycosphaerellagraminicola), yellow leaf blotch (Pyrenophoratritici-repentis). Corn Diseases: smut (Ustilagomaydis), Gomaha blight (Cochliobolusheterostrophus), southern rust (Pucciniapolysora), gray leaf spot disease (Cercosporazeae-maydis), seedling wilt (Rhizoctonia solani). Diseases of citrus: black spot disease (Diaporthecitri), fruit rot (Penicilliumdigitatum), Phytophthora disease (Phytophthoraparasitica). Apple diseases: blossom disease (Moniliniamali), canker (Valsaceratosperma), powdery mildew (Podosphaeraleucotricha), speckled leaf fall disease (Alternariaalternata apple pathotype), scab (Venturiainaequalis), anthracnose (Colletotrichumacutatum) , plague (Phytophtora cactorum), brown spot (Diplocarponmali), early blight (Botryosphaeriaberengeriana), Marssonia leaf blotch, Grapes of disease: evening rot (Glomerellacingulata), powdery mildew (Uncinulanecator), rust (Phakopsoraampelopsidis), black lot disease (Guignardiabidwellii), downy mildew (Plasmoparaviticola), cucurbits diseases: anthracnose (Colletotrichumlagenarium), powdery mildew (Sphaerothecafuliginea), vine blight (Mycosphaerellamelonis), Fusarium disease (Fusarium oxysporum), downy mildew (Pseudoperonosporacubensis), late blight (Phytophthora sp. ), seedling blight (Pythium sp), tomato diseases: early blight (Alternaria solani), leaf mold disease (Cladosporiumfulvum), late blight (Phytophthorainfestans), Eggplant disease: Phoma blight (Phomopsisvexans), powdery mildew (Erysiphecichoracearum), Diseases of cruciferous vegetables: black spot (Alternaria japonica), white spot disease (Cercosporellabrassicae), clubroot (Plasmodiophora brassicae), downy mildew (Peronosporaparasitica), Peanut Diseases: Southern blight (Sclerotium rolfsii), Rhizoctonia root rot, Fusarium root rot. Diseases of potato: early blight (Alternaria solani), late blight (Phytophthorainfestans), scarlet rot (Phytophthoraerythroseptica), powdery scab (Spongospora subterranean f spsubterranea), black scurf (Rhizoctonia solani), Diseases of rapeseed: rot (Sclerotiniasclerotiorum), seedling wilt caused by bacteria of the genus Rhizoctonia (Rhizoctonia solani). Cotton diseases : Rhizoctonia seedling damping-off disease caused by Rhizoctonia solani, wilt by Fusarium oxysporum.

The composition of the present invention also can be used to control Alternaria leaf spot in cereals, fruit and vegetables, Ascochyta blight in pulse crops, Botrytis cinerea (gray mold) in strawberries, tomatoes, sunflower and grapes, Cercospora leaf spot, Cercosporaarachidicola in groundnuts, Clavicepspurpurea in oilseeds,cereals, millets, Cochliobolussativus in cereals, Colletotrichum species in cereals, pulses, fruits, vegetables, Erysiphecichoracearum and Sphaerothecafuiiginea in cucurbits, Erysiphegraminis in cereals, Fusarium species in cereals, grains, fruits and vegetables, Gaumannomycesgraminis in cereals and lawns, Helminthosporium species in maize, rice and other cereals, Hemileiavastatrix on coffee, Leucostoma canker of stone fruits, Macrophomina disease in pulses, oilseeds and cereals, Monilinia disease in stone fruits, pome fruits, rose and other flower crops, Monosporascus Root Rot and Vine Decline of Melons, Mycosphaerella disease in banana, Penicillium disease in citrus, pome fruits and vegetables, Phakopsorapachyrhizi in pulses and oilseeds, Phragmidiummucronatum in roses, Phytophthorainfestans in potatoes and tomatoes, Plasmoporaviticola in grapes, Podosphaeraleucotricha in apples, Pseudocercosporellaherpotrichoides in wheat and barley, Puccinia species in cereals, Pythium spp., in vegetables, pulses and cereals, Pyrenophoragraminea in small grain cereals, wheat, barley, Pyriculariaoryzae in rice, Rhizoctonia species in cotton, soybean, cereals, maize, potatoes, rice and lawns, Septorianodorum in wheat, Sclerotiniahomeocarpa in lawns, Sphacelothecareilliana in maize, Tilletia species in cereals, Typhulaincarnata in bartey, Uncinulanecator, Guignardlabidwellii and Phomopsisviticola in vines, Urocystis spp., in cereals and oilseeds rape, Ustilago species in cereate and maize, Venturiainaequalis (scab) in apples, Verticillium wilt in potato, tomato and trees.

The composition according to the invention can be applied to any and all developmental stages of pests, such as egg, larva, pupa, and adult. The pests may be controlled by contacting the target pest, its food supply, habitat, breeding ground or its locus with a pesticidally effective amount of the inventive mixtures or of compositions comprising the mixtures

As per one embodiment, the pesticidal composition of the present invention is to be applied as foliar spray with the help of manual operated knap sack sprayer, battery or power operated or machine or tractor operated sprayer with the spray volume of 250 to 750 liters per hectare.

The compositions are applied in an amount of from 0.1 ml or g/ha to 2000 ml or g/ha as foliar spray, soil drench, soil broadcast, through drip irrigation.

The ratio of Anthranilamide selected from Flubendiamide or Chlorantraniliprole and at least one fungicide, wherein fungicide is selected from Azoxystrobin, Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole and Prothioconazole, and the total amount of the mixture, depends on many factors, including the type and the occurrence of the pests to be controlled. For each application, the optimum ratios and total amounts to be employed can in each case be determined by routine experimentation.

Accordingly, in one embodiment a pesticide comprises a mixture including a pesticidally effective amount of Anthranilamide selected from Flubendiamide or Chlorantraniliprole and at least one fungicide, wherein fungicide is selected from Azoxystrobin, Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole and Prothioconazole with at least one agriculturally acceptable adjuvant and/or carrier. A “pesticidally effective amount” is an amount of active ingredient or a combination of active ingredients that is effective to prevent or reduce damage to a plant caused by any pest or to repel, deter or destroy a pest or to cause an adverse effect to an individual insect or an insect population, including, for example, deviations from natural development, killing, regulation, and the like. Suitable adjuvants or carriers should not be phytotoxic to valuable crops, particularly at the concentrations employed in applying the compositions for pest control in the presence of crops, and should not react chemically with pesticidal components of the mixture or other composition ingredients. Such mixtures can be designed for application directly to seeds or to a field locus or can be concentrates or formulations that are normally diluted with additional carriers and/or adjuvants before application as described further herein below. Solid forms of the pesticide can be, for example, dusts, granules, water dispersible granules, or wettable powders. Liquid forms of the pesticide can be, for example, emulsifiable concentrates, solutions, emulsions or suspensions, as discussed further herein below.

Examples of suitable solid carriers include talc, pyrophyllite clay, silica, attapulgus clay, kaolin clay, kieselguhr, chalk, diatomaceous earth, lime, calcium carbonate, bentonite clay, Fuller's earth, cottonseed hulls, wheat flour, soybean flour, pumice, wood flour, walnut shell flour, lignin, and the like or mixtures thereof.

Other ingredients, or customary adjuvants or inactive excipients, that are often used in agrochemical compositions, and that can be included in various compositions described herein, include, but are not limited to, dispersing agents, wetting agent, antifoam agents, biocide, anti-freezing agent, suspension aid, thickening agents (also referred to as “thickeners”), quick coating agent or sticking agents (also referred to as “stickers” or “binders”).

Pesticide compositions can be frequently applied as aqueous suspensions or emulsions prepared from concentrated formulations of such compositions. Such water-soluble, water-suspendable, or emulsifiable formulations are either solids, usually known as wettable powders, or water dispersible granules, or liquids usually known as emulsifiable concentrates, or aqueous suspensions. Wettable powders, which may be compacted to form water dispersible granules, comprise an intimate mixture of the pesticide composition, a carrier, and surfactants. The carrier is usually chosen from among the attapulgite clays, the montmorillonite clays, the diatomaceous earths, or the purified silicates. Effective surfactants, which can comprise from about 0.5% to about 10% of the wettable powder, are found among sulfonatedlignins, condensed naphthalenesulfonates, naphthalenesulfonates, alkylbenzenesulfonates, alkyl sulfates, and nonionic surfactants such as ethylene oxide adducts of alkyl phenols.

Emulsifiable concentrates comprise a convenient concentration of a pesticide composition dissolved in a carrier that is either a water miscible solvent or a mixture of water-immiscible organic solvent and emulsifiers. Useful organic solvents include aromatics, especially xylenes and petroleum fractions, especially the high-boiling naphthalenic and olefinic portions of petroleum such as heavy aromatic naphtha. Other organic solvents may also be used, such as the terpenic solvents including rosin derivatives, aliphatic ketones such as cyclohexanone, and complex alcohols such as 2-ethoxyethanol. Suitable emulsifiers for emulsifiable concentrates are chosen from conventional anionic and nonionic surfactants.

Aqueous suspensions comprise suspensions of water-insoluble pesticide compositions dispersed in an aqueous carrier. Suspensions are prepared by finely grinding the pesticide composition and vigorously mixing it into a carrier comprised of water and surfactants. Ingredients, such as inorganic salts and synthetic or natural gums, may also be added, to increase the density and viscosity of the aqueous carrier. It is often most effective to grind and mix the pesticide composition at the same time by preparing the aqueous mixture and homogenizing it in an implement such as a sand mill, ball mill, or piston-type homogenizer.

Pesticide compositions may also be applied as granular formulations that are particularly useful for applications to the soil. Granular formulations include the pesticide composition dispersed in a carrier such as, for example, a carrier that comprises clay or a similar substance. Such formulations are usually prepared by dissolving the pesticide composition in a suitable solvent and applying it to a granular carrier which has been pre-formed to the appropriate particle size, in the range of from about 0.5 to 3 mm. Such formulations may also be formulated by making a dough or paste of the carrier and pesticide composition and crushing and drying to obtain the desired granular particle size.

It is equally practical to apply a pesticide composition in the form of a solution in an appropriate organic solvent, usually petroleum oil, such as the spray oils, which are widely used in agricultural chemistry.

Pesticide compositions can also be applied in the form of an aerosol formulation. In such formulations, the pesticide composition is dissolved or dispersed in a carrier, which is a pressure-generating propellant mixture. The aerosol formulation is packaged in a container from which the mixture is dispensed through an atomizing valve.

Pesticide baits are formed when the pesticide composition is mixed with food or an attractant or both. When the pests eat the bait they also consume the pesticide composition. Baits may take the form of granules, gels, flowable powders, liquids, or solids. They may be used in or around pest harborages.

Fumigants are pesticides that have a relatively high vapor pressure and hence can exist as a gas in sufficient concentrations to kill pests in soil or enclosed spaces. The toxicity of the fumigant is proportional to its concentration and the exposure time. They are characterized by a good capacity for diffusion and act by penetrating the pest's respiratory system or being absorbed through the pest's cuticle. Fumigants are applied to control stored product pests under gas proof sheets, in gas sealed rooms or buildings or in special chambers.

Generally, with baits, the baits are placed in the ground where the pests can come into contact with the bait. Baits can also be applied to a surface of a building, (horizontal, vertical, or slant, surface) where, for example, ants, termites, cockroaches, and flies, can come into contact with the bait.

Because of the unique ability of the eggs of some pests to resist pesticides repeated applications may be desirable to control newly emerged larvae.

The present compositions can be applied to a locus by the use of conventional ground or aerial dusters, sprayers, and granule applicators, by addition to irrigation or paddy water, and by other conventional means known to those skilled in the art.

A dispersant is a substance which adsorbs onto the surface of particles and helps to preserve the state of dispersion of the particles and prevents them from re-aggregating. Dispersants are added to agrochemical formulations to facilitate dispersion and suspension during manufacture, and to ensure the particles re-disperse into water in a spray tank. They are widely used in wettable powders, suspension concentrates and water-dispersible granules. Surfactants that are used as dispersants have the ability to adsorb strongly onto a particle surface and provide a charged or steric barrier to re-aggregation of particles. The most commonly used surfactants are anionic, non-ionic, or mixtures of the two types. For wettable powder formulations, the most common dispersants are sodium lignosulphonates. For suspension concentrates, very good adsorption and stabilization are obtained using polyelectrolytes, such as sodium naphthalene sulphonate formaldehyde condensates. Tristyrylphenolethoxylate phosphate esters are also used. Non-ionics such as alkylarylethylene oxide condensates and EO-PO block copolymers are sometimes combined with anionics as dispersants for suspension concentrates. In recent years, new types of very high molecular weight polymeric surfactants have been developed as dispersants. These have very long hydrophobic ‘backbones’ and a large number of ethylene oxide chains forming the ‘teeth’ of a ‘comb’ surfactant. These high molecular weight polymers can give very good long-term stability to suspension concentrates because the hydrophobic backbones have many anchoring points onto the particle surfaces. Examples of dispersants used herein include but not limited to sodium lignosulphonates; sodium naphthalene sulphonate formaldehyde condensates; tristyrylphenolethoxylate phosphate esters; aliphatic alcohol ethoxylates; alky ethoxylates; EO-PO block copolymers; and graft copolymers or mixtures thereof.

Anti-freezing agent as used herein can be selected from the group consisting of polyethylene glycols, methoxypolyethylene glycols, polypropylene glycols, polybutylene glycols, glycerin and ethylene glycol.

Water-based formulations often cause foam during mixing operations in production. In order to reduce the tendency to foam, anti-foam agents are often added either during the production stage or before filling into bottles. Generally, there are two types of anti-foam agents, namely silicones and non-silicones. Silicones are usually aqueous emulsions of dimethyl polysiloxane while the non-silicone anti-foam agents are water-insoluble oils, such as octanol and nonanol, or silica. In both cases, the function of the anti-foam agent is to displace the surfactant from the air-water interface.

A wetting agent is a substance that when added to a liquid increases the spreading or penetration power of the liquid by reducing the interfacial tension between the liquid and the surface on which it is spreading. Wetting agents are used for two main functions in agrochemical formulations: during processing and manufacture to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates; and during mixing of a product with water in a spray tank or other vessel to reduce the wetting time of wettable powders and to improve the penetration of water into water-dispersible granules. Examples of wetting agents used in wettable powder, suspension concentrate, and water-dispersible granule formulations include but not limited to sodium lauryl sulphate; sodium dioctylsulphosuccinate; alkyl phenol ethoxylates; and aliphatic alcohol ethoxylates or mixtures thereof.

Suspension aid in the present description denotes a natural or synthetic, organic or inorganic material with which the active substance is combined in order to facilitate its application to the plant, to the seeds or to the soil. This carrier is hence generally inert, and it must be agriculturally acceptable, in particular to the plant being treated. The carrier may be solid (clays, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, and the like or mixtures thereof) or liquid (water, alcohols, ketones, petroleum fractions, aromatic or paraffinic hydrocarbons, chlorinated hydrocarbons, liquefied gases, and the like or mixtures thereof).

Biocides / Microorganisms cause spoilage of formulated products. Therefore anti-microbial agents are used to eliminate or reduce their effect. Examples of such agents include, but are not limited to: propionic acid and its sodium salt; sorbic acid and its sodium or potassium salts; benzoic acid and its sodium salt; p-hydroxy benzoic acid sodium salt; methyl p-hydroxy benzoate; and biocide such as sodium benzoate, 1,2-benzisothiazoline-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, potassium sorbate, parahydroxy benzoates or mixtures thereof.

Thickeners or gelling agents are used mainly in the formulation of suspension concentrates, emulsions and suspoemulsions to modify the rheology or flow properties of the liquid and to prevent separation and settling of the dispersed particles or droplets. Thickening, gelling, and anti-settling agents generally fall into two categories, namely water-insoluble particulates and water-soluble polymers. It is possible to produce suspension concentrate formulations using clays and silicas. Examples of these types of materials, include, but are limited to, montmorillonite, e.g. bentonite; magnesium aluminum silicate; and attapulgite. Water-soluble polysaccharides have been used as thickening-gelling agents for many years. The types of polysaccharides most commonly used are natural extracts of seeds and seaweeds are synthetic derivatives of cellulose or mixtures thereof. Examples of these types of materials include, but are not limited to, guar gum; locust bean gum; carrageenam; xanthan gum; alginates; methyl cellulose; sodium carboxymethyl cellulose (SCMC); hydroxyethyl cellulose (HEC) or mixtures thereof. Other types of anti-settling agents are based on modified starches, polyacrylates, polyvinyl alcohol and polyethylene oxide or mixtures.

The quick coating agent can be a conventionally available sticker, for example polyesters, polyamides, poly- carbonates, polyurea and polyurethanes, acrylate polymers and copolymers, styrene copolymers, butadiene copolymers, polsaccharides such as starch and cellulose derivatives, vinylal- cohol, vinylacetate and vinylpyrrolidone polymers and copolymers, polyethers, epoxy, phenolic and melamine resins, polyolefins and define copolymersand mixtures thereof. Examples of preferred polymers are acrylate polymers such as poly(methacrylate), poly( ethyl methacrylate ), poly(methylmethacrylate), acrylate copoylmers and styrene-acrylic copolymers as defined herein below , poly(styrene-co maleic anhydride), cellulosic polymers such as ethyl cellulose, cellulose acetate, cellulose acetatebutyrate, acetylated mono-, di-, and triglycerides, poly(vinylpyrrolidone), vinyl acetate polymers and copolymers, poly(alkylene glycol), styrene butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more of these. Polymers that are biodegradable are also useful in the present invention. As used herein, a polymer is biodegradable if is not water soluble, but is degraded over a period of several weeks when placed in an application environment. Examples of biodegradable polymers that are useful in the present method include biodegradable polyesters, starch, polylactic acid -starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch ester aliphatic polyester blends, modified corn starch, polycaprolactone, poly(n-amylmethacrylate), wood rosin, polyan- hydrides, polyvinylalcohol, polyhydroxybutyrate-valerate, biodegradable aliphatic polyesters, and polyhydroxybutyrate or mixtures thereof.

Buffering agent as used herein is selected from group consisting of calcium hydroxyapatite, Potassium Dihydrogen Phosphate, Sodium Hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphates, carbonated calcium phosphates, amine monomers, lactate dehydrogenase and magnesium hydroxide.

The solvent for the formulation of the present invention may include water, water-soluble alcohols and dihydroxy alcohol ethers. The water-soluble alcohol which can be used in the present invention may be lower alcohols or water-soluble macromolecular alcohols. The term "lower alcohol", as used herein, represents an alcohol having 1-4 carbon atoms, such as methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol, etc. Macromolecular alcohol is not limited, as long as it may be dissolved in water in a suitable amount range, e.g., polyethylene glycol, sorbitol, glucitol, etc. The examples of suitable dihydroxy alcohol ethers used in the present invention may be dihydroxy alcohol alkyl ethers or dihydroxy alcohol aryl ethers. The examples of dihydroxy alcohol alkyl ether include ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether, dipropylene glycol ethyl ether, etc. The examples of dihydroxy alcohol aryl ethers include ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, dipropylene glycol phenyl ether, and the like. Any of the above mentioned solvent can be used either alone or in combination thereof.

WDG formulations offer a number of advantages in packaging, ease of handling and safety. The WDG are preferably of uniform size and which are free flowing, low dusting and readily disperse in water to form a homogenous solution of very small particles which may pass through conventional spray nozzles. Ideally WDG formulations when dispersed in water under gentle agitation for five minutes have residues of less than 0.01% on a 150 µm sieve screen and less than 0.5% on a 53 µm screen. The granules can usually be measured accurately by volume which is convenient for the end user.

Wettable powders can be prepared by dissolving insecticide in sufficient solvent with or without heating to give a solution and spraying the resulting solution onto a solid carrier or diluent. Alternatively insecticides which are solid and of a friable nature may be blended and ground with mineral diluents. The carriers generally used for wettable powders are sorbent inorganic materials commonly of mineral origin such as the kaolinites, montmorillonites, attapulgites, diatomaceous earths and vermiculites. Diluents generally used in toxicant formulations are such inert solids as talc, pyrophyllite, frianite, pumice and as per the knowledge of a person skilled in the art.

The organic solvent is charged into a vessel and the clay or silica type rheology modifier is added into the vessel with high shear mixing to allow complete wetting of the rheology modifier. The insecticide, safener, dispersants, and emulsifier may then be added to the vessel under shearing conditions until the formation of uniform oil dispersion is achieved. The polymer or oligomer capable of hydrogen bonding may be introduced into the oil dispersion at a point where the desired thickening effect is achieved.

The SC composition can be prepared by below described method;
STEP-I: Adding anti-microbial agent and gum in water under continuous stirring followed by slow addition. Continuing stirring until homogeneous dispersion is formed.
STEP-II: Mixing anti-freezing agent, dispersant, wetting agent, anti-microbial agent and anti-foaming agent in water for 30 minute until homogeneous solution is formed. Finally add Flubendiamide or Chlorantraniliprole and at least one fungicide selected from Azoxystrobin, Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole and Prothioconazole (With proviso that Azoxystrobin is not combined with Chorantraniliprole) and at least one agrochemically acceptable excipient which is added slowly under continuous stirring at 30 minute till homogeneous dispersion is obtained. Milling the slurry through bead mill until required particle size is achieved.
Step-III: Adding rest of water, anti-foaming agent and gum solution under continuous stirring to get desired viscosity of the suspension. Continue stirring for about 4 hr to obtain homogeneous composition.

Emulsifiable concentrate (EC) formulations are a blend of insecticide, organic solvent, and surfactants. When the solution is diluted into water, a spontaneous milky emulsion forms with dispersed phase droplets. When sprayed, this dilute emulsion gives a uniform and accurate application of insecticide on the crop, which is essential for effective pest control. The formulation of the insecticide into an Emulsifiable Concentrate can ensure uniform spreading and wetting under normal spray and weather conditions.

ZC is a mixed formulation of CS and SC and is a stable aqueous suspension of microcapsules and solid fine particles, each of which contains Flubendiamide or Chlorantraniliprole and at least one fungicide, wherein fungicide can be selected from Azoxystrobin, Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole and Prothioconazoleand at least one agrochemically acceptable excipient. The formulation is intended for dilution into water prior to spray application. Formulating the active ingredients together eliminates the need for tank mixing, which can lead to incompatibility, and facilitates control of a wider range of pests with fewer applications. Like other aqueous liquid formulations, ZC formulations are easy to handle and measure, dust free, non-flammable and offer good miscibility with water.

Flubendiamide or Chlorantraniliprole and at least one fungicide, wherein fungicide can be selected from Azoxystrobin, Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole and Prothioconazole encapsulated for various purposes, such as to increase the residual biological activity, or to reduce the acute toxicity, or to obtain a physical or chemically stable water-based formulation. The purpose determines whether the “free” active ingredient and the “release rate” are relevant properties of a specific product.

The process for preparing the present agrochemical composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the composition. However all such variation and modification is still covered by the scope of present invention.

EXAMPLES
Example 1: Chlorantraniliprole 8% + Difenoconazole 20% SE (Suspo Emulsion)
Composition %
Chlorantraniliprole(95% purity) 8.63
Difenoconazole (95% purity) 21.26
n-Octanol 11.00
Copolymer butanol EO/PO 2.00
Tristrylphenol with 16 moles EO 2.00
Tristrylphenol polyethoxyester phosphate 1.50
Acrylic graft copolymer 1.00
Polydimethyl siloxane 0.50
1,2-benzisothiazol-3-one 0.10
Naphthalene sulfonic acid,sodium salt condensate with formaldehyde 0.50
Xanthan Gum 0.10
DL-propanediol-(1,2) 5.00
Water 46.41
TOTAL 100.00

Procedure:
Suspo Emulsion (SE) :
Step 1 Gum Solution should be made 12-18 hour prior to use. Take required quantity of water, biocide, and defoamer and homogenize, then slowly add gum powder to it and stir till complete dissolution.
Step 2 Oil phase is made by mixing required quantity of oil soluble emulsifier in required quantity of N-Octanol and technical
Step 3 Simultaneously make aqueous phase by mixing surfactants, antifreeze, antifoam, filler/ suspending agent in water. Once homogenize add technical (water insoluble) to this solution and form a slurry using high shear homogenizer for 60 minutes and then milled through Sand Mill
Step 4 Once both phases are ready add Oil phase to aqueous phase slowly under high shear homogenization.
Step 5 After complete addition stir the mixture for 60 more minutes under high shear stirring.
Step 6 Upon approval for particle form lab, gum solution was added and final sample is provided to QC for approval.
Step 7 After approval material is packed in required pack sizes.

Example 2: Flubendiamide 8% + Difenoconazole 10% SE (Suspo Emulsion)
Composition %
Flubendiamide (95% purity) 8.63
Difenoconazole ( % purity) 21.26
n-Octanol 11.00
Copolymer butanol EO/PO 2.00
Tristrylphenol with 16 moles EO 2.00
Tristrylphenol polyethoxyester phosphate 1.50
Acrylic graft copolymer 1.00
Polydimethyl siloxane 0.50
1,2-benzisothiazol-3-one 0.10
Naphthalene sulfonic acid, sodium salt condensate with formaldehyde 0.50
Xanthan Gum 0.10
DL-propanediol-(1,2) 5.00
Water 46.41
TOTAL 100.00

Procedure: As per example 1

Example 3: Chlorantraniliprole 6% + Flusilazole 25% SE (Suspo Emulsion)
Composition %
Chlorantraniliprole(95% purity) 6.53
Flusilazole (95% purity) 26.53
n-Octanol 11.00
Copolymer butanol EO/PO 2.00
Tristrylphenol with 16 moles EO 2.00
Tristrylphenol polyethoxyester phosphate 1.50
Acrylic graft copolymer 1.00
Polydimethyl siloxane 0.50
1,2-benzisothiazol-3-one 0.10
Naphthalene sulfonic acid,sodium salt condensate with formaldehyde 0.50
Xanthan Gum 0.10
DL-propanediol-(1,2) 5.00
Water 43.24
TOTAL 100.00
Procedure: As per example 1.

Example 4: Flubendiamide 6% + Flusilazole 12.5% SE (Suspo Emulsion)
Composition %
Flubendiamide (95% purity) 6.53
Flusilazole (95% purity) 13.37
n-Octanol 11.00
Copolymer butanol EO/PO 2.00
Tristrylphenol with 16 moles EO 2.00
Tristrylphenol polyethoxyester phosphate 1.50
Acrylic graft copolymer 1.00
Polydimethyl siloxane 0.50
1,2-benzisothiazol-3-one 0.10
Naphthalene sulfonic acid,sodium salt condensate with formaldehyde 0.50
Xanthan Gum 0.10
DL-propanediol-(1,2) 5.00
Water 56.40
TOTAL 100.00
Procedure: As per example 1

Example 5: Chlorantraniliprole 8% + Difenoconazole 20% SC
Composition %
Chlorantraniliprole(95% purity) 8.63
Difenoconazole (95% purity) 21.26
Acrylic graft copolymer 3.00
Block copolymer on butanol 4.00
Lignosulfonic acid, ethoxylated, sodium salts 1.00
Silicone antifoam 0.50
Benzisothiazoline 0.10
Glycol 5.00
Polysaccharides 0.10
DM water 56.41
TOTAL 100.00

Procedure:
Step 1 Gum Solution should be made 12-18 hour prior to use. Take required quantity of water, biocide, and defoamer and homogenize, then slowly add gum powder to it and stir till complete dissolution.
Step 2 Charge required quantity of DM water need to be taken in designated vessel for Flowable concentrate/ Suspension concentrate/ Flowable slurry production.
Step 3 Add required quantity of Wetting agent, dispersing agent & suspending agents, colourant/deye and homogenize the contents for 45 – 60 minutes using high shear homogenizer.
Step 4 Then add technical and other remaining adjuvants excluding ‘antifreeze & thickeners’ are added to it and homogenized to get uniform slurry ready for grinding.
Step 5 Before grinding half the quantity of antifoam was added and then material was subjected to three cycles of grinding in Dyno mill.
Step 6 Half quantity of the antifoam was added along with antifreeze after grinding process completes and before sampling for in process analysis.
Step 7 Finally add gum solution to this formulation and send to QC for quality check

Example 6: Flubendiamide 8% + Difenoconazole 10% SC
Composition %
Flubendiamide (95% purity) 8.63
Difenoconazole (95% purity) 10.74
Acrylic graft copolymer 3.00
Block copolymer on butanol 4.00
Lignosulfonic acid, ethoxylated, sodium salts 1.00
Silicone antifoam 0.50
Benzis
othiazoline 0.10
Glycol 5.00
Polysaccharides 0.10
DM water 66.93
TOTAL 100.00
Procedure: As per example 5

Example 7: Chlorantraniliprole 6% + Flusilazole 25% SC
Composition %
Chlorantraniliprole(95% purity) 6.53
Flusilazole (95% purity) 26.53
Acrylic graft copolymer 3.00
Block copolymer on butanol 4.00
Lignosulfonic acid, ethoxylated, sodium salts 1.00
Silicone antifoam 0.50
Benzisothiazoline 0.10
Glycol 5.00
Polysaccharides 0.10
DM water 53.24
TOTAL 100.00
Procedure: As per example 5

Example 8: Flubendiamide 6% + Flusilazole 12.5% SC
Composition %
Flubendiamide (95% purity) 6.53
Flusilazole (95% purity) 13.37
Acrylic graft copolymer 3.00
Block copolymer on butanol 4.00
Lignosulfonic acid, ethoxylated, sodium salts 1.00
Silicone antifoam 0.50
Benzisothiazoline 0.10
Glycol 5.00
Polysaccharides 0.10
DM water 66.40
TOTAL 100.00
Procedure: As per example 5

Example 9: Chlorantraniliprole 6% + Cyproconazole 20% SC
Composition %
Chlorantraniliprole(95% purity) 6.53
Cyproconazole (95% purity) 21.26
Acrylic graft copolymer 3.00
Block copolymer on butanol 4.00
Lignosulfonic acid, ethoxylated, sodium salts 1.00
Silicone antifoam 0.50
Benzisothiazoline 0.10
Glycol 5.00
Polysaccharides 0.10
DM water 71.60
TOTAL 113.09
Procedure: As per example 5

Example 10: Flubendiamide 6% + Cyproconazole 10% SC
Composition %
Flubendiamide (95% purity) 6.53
Cyproconazole (95% purity) 10.74
Acrylic graft copolymer 3.00
Block copolymer on butanol 4.00
Lignosulfonic acid, ethoxylated, sodium salts 1.00
Silicone antifoam 0.50
Benzisothiazoline 0.10
Glycol 5.00
Polysaccharides 0.10
DM water 68.50
TOTAL 99.47
Procedure: As per example 5

Example 11: Chlorantraniliprole 12% + Cyproconazole 40% WG
Composition %
Chlorantraniliprole(95%) 12.84
Cyproconazole (95% purity) 42.32
Sodium Polycarboxylate 7.00
Sodium Lauryl Sulfate 3.00
Sodium alkyl naphthalene sulfonate blend 3.00
Sodium alkylnaphthalenesulfonate, formaldehyde condensate 2.00
Silicone based antifoam 0.50
Starch 5.00
Lactose anhydrous 24.34
TOTAL 100.00

Procedure:
Step 1 Charge the required quantity of filler, wetting agent, dispersing agent, and suspending agent, & technical in premixing blender for homogenization for 30 minutes.
Step 2 Pre-blended material is than grinded through Jet mill/ air classifier mills. Finely grinded material is blended in post blender till it becomes homogeneous. (for approx. 1.5 hr)
Step 3 Homogeneous material is analysed. After getting approval from QC dept. material is unloaded into 25 kg. HDPE bag with LDPE liner inside.
Step 4 Finely grinded powder is mixer with required quantity of water to form extrudable dough.
Step 5 Dough is passed through extruder to get granules of required size.
Step 6 Wet granules are passed through Fluidised bed drier and further graded using vibrating screens.
Step 7 Final product is sent for QC approval.
Step 8 After approval material is packed in required pack sizes.

Example 12: Flubendiamide 12% + Cyproconazole 20% WDG
Composition %
Flubendiamide (95%) 12.84
Cyproconazole (95% purity) 21.26
Sodium Polycarboxylate 7.00
Sodium Lauryl Sulfate 3.00
Sodium alkyl naphthalene sulfonate blend 3.00
Sodium alkylnaphthalenesulfonate, formaldehyde condensate 2.00
Silicone based antifoam 0.50
Starch 5.55
Lactose anhydrous 44.85
TOTAL 100.00
Procedure: As per example 11

Example 13: Chlorantraniliprole 6% + Epoxyconazole 20% SC
Composition %
Chlorantraniliprole(95% purity) 6.53
Epoxyconazole (95% purity) 21.26
Acrylic graft copolymer 3.00
Block copolymer on butanol 4.00
Lignosulfonic acid, ethoxylated, sodium salts 1.00
Silicone antifoam 0.50
Benzisothiazoline 0.10
Glycol 5.00
Polysaccharides 0.10
DM water 58.51
TOTAL 100.00
Procedure: As per example 5

Example 14: Flubendiamide 6% + Epoxyconazole 10% SC
Composition %
Flubendiamide (95% purity) 6.53
Epoxyconazole (95% purity) 10.74
Acrylic graft copolymer 3.00
Block copolymer on butanol 4.00
Lignosulfonic acid, ethoxylated, sodium salts 1.00
Silicone antifoam 0.50
Benzisothiazoline 0.10
Glycol 5.00
Polysaccharides 0.10
DM water 69.03
TOTAL 100.00
Procedure: As per example 5

Example 15: Chlorantraniliprole 12% + Epoxyconazole 40% WG
Composition %
Chlorantraniliprole(95%) 12.84
Epoxyconazole (95% purity) 42.32
Sodium Polycarboxylate 7.00
Sodium Lauryl Sulfate 3.00
Sodium alkyl naphthalene sulfonate blend 3.00
Sodium alkylnaphthalenesulfonate, formaldehyde condensate 2.00
Silicone based antifoam 0.50
Starch 5.00
Lactose anhydrous 24.34
TOTAL 100.00
Procedure: As per example 11

Example 16: Flubendiamide 12% + Epoxyconazole 20% WG
Composition %
Flubendiamide (95%) 12.84
Epoxyconazole (95% purity) 21.26
Sodium Polycarboxylate 7.00
Sodium Lauryl Sulfate 3.00
Sodium alkyl naphthalene sulfonate blend 3.00
Sodium alkylnaphthalenesulfonate, formaldehyde condensate 2.00
Silicone based antifoam 0.50
Starch 5.55
Lactose anhydrous 44.85
TOTAL 100.00
Procedure: As per example 11

Example 17: Chlorantraniliprole 6% + Prothioconazole 25% SE (Suspo Emulsion)
Composition %
Chlorantraniliprole(95% purity) 6.53
Prothioconazole (97% purity) 25.98
n-Octanol 11.00
Copolymer butanol EO/PO 2.00
Tristrylphenol with 16 moles EO 2.00
Tristrylphenol polyethoxyester phosphate 1.50
Acrylic graft copolymer 1.00
Polydimethyl siloxane 0.50
1,2-benzisothiazol-3-one 0.10
Naphthalene sulfonic acid,sodium salt condensate with formaldehyde 0.50
Xanthan Gum 0.10
DL-propanediol-(1,2) 5.00
Water 43.79
TOTAL 100.00
Procedure: As per example 1

Example 18: Flubendiamide 6% + Prothioconazole 12.5% SE (Suspo Emulsion)
Composition %
Flubendiamide (95% purity) 6.53
Prothioconazole (97% purity) 13.09
n-Octanol 11.00
Copolymer butanol EO/PO 2.00
Tristrylphenol with 16 moles EO 2.00
Tristrylphenol polyethoxyester phosphate 1.50
Acrylic graft copolymer 1.00
Polydimethyl siloxane 0.50
1,2-benzisothiazol-3-one 0.10
Naphthalene sulfonic acid,sodium salt condensate with formaldehyde 0.50
Xanthan Gum 0.10
DL-propanediol-(1,2) 5.00
Water 56.68
TOTAL 100.00
Procedure: As per example 11

Example 19: Chlorantraniliprole 6% + Prothioconazole 25% Suspension Concentrate
Composition %
Chlorantraniliprole(95% purity) 6.53
Prothioconazole (97% purity) 25.98
Acrylic graft copolymer 3.00
Block copolymer on butanol 4.00
Lignosulfonic acid, ethoxylated, sodium salts 1.00
Silicone antifoam 0.50
Benzisothiazoline 0.10
Glycol 5.00
Polysaccharides 0.10
DM water 53.79
TOTAL 100.00
Procedure: As per example 5

Example 20: Flubendiamide 6% + Prothioconazole 12.5% Suspension Concentrate
Composition %
Flubendiamide (95% purity) 6.53
Prothioconazole (97% purity) 13.09
Acrylic graft copolymer 3.00
Block copolymer on butanol 4.00
Lignosulfonic acid, ethoxylated, sodium salts 1.00
Silicone antifoam 0.50
Benzisothiazoline 0.10
Glycol 5.00
Polysaccharides 0.10
DM water 66.68
TOTAL 100.00
Procedure: As per example 5

Example 23: Chlorantraniliprole 0.4% + Difenoconazole 1% GR (Granules)
Composition %
1 Chlorantraniliprole (95%) 0.463
2 Difenoconazole (95%) 1.157
3 Bentonite 80.38
4 China Clay 7
5 Alcohol Ethoxylates 0.5
6 Copolymer butanol EO/PO 0.5
7 Dimethyl sulfoxide 10
TOTAL 100

Procedure:
Step 1 Charged required quantity of carrier into the booth mixture with help of bucket elevator, then add other raw material (as technical, solvent, Surfactant, stabilizer, and binder) into the booth mixture and at this point add filler and allow mixing for another 20 minutes for homogenization.
Step 2 After completion of raw material addition and proper mixing, stop booth mixture for sampling.
Step 3 Sample is sent for QC approval and approved material is unloaded in 25 Kg HDPE woven bags.

Example 24: Flubendiamide 0.6% + Difenoconazole 1% GR (Granules)
Composition %
1 Flubendiamide (95%) 0.684
2 Difenoconazole (95%) 1.157
3 Dimethyl sulfoxide 10
4 China Clay 7
5 ALCOHOL ETHOXYLATES 0.5
6 Copolymer butanol EO/PO 0.5
7 Bentonite 80.159
TOTAL 100
Procedure: As per example 23

Example 25: Flubendiamide 0.6% + Azoxystrobin 1.5% GR (Granules)
Composition %
1 Flubendiamide (95%) 0.684
2 Difenoconazole (95%) 1.684
3 Dimethyl sulfoxide 10
4 China Clay 7
5 ALCOHOL ETHOXYLATES 0.5
6 Copolymer butanol EO/PO 0.5
7 Bentonite 79.632
TOTAL 100
Procedure: As per example 23

Example 26: Storage stability
Storage stability analysis has been performed on all of the above formulations as disclosed in the above examples as per below conditions
Initial Heat stability study at 54 + 2 0C for 14 days Cold storage stability at 0 + 2 0C for 14 days Room Temperature storage up to 12 months

All the storage stability data were satisfactory and complied as per specification mentioned below;
Specification
Parameters In House
Description The material shall be in the form of pourable white to brown colour liquid suspension devoid of any lumps and sediment and clear liquid on top
Anthranilamide Content 5.70 - 6.6
Anthranilamide Suspensibility Mini 80%
Fungicide Content 23.75 - 26.25
Flusilazole Suspensibility Mini 80%
pH 5 to 9
Particle size D50 <3, D90 <10
Pourability 95 % min
Specific gravity 1.05 – 1.15
Viscosity 350 -900 cps

Example 24: Field efficacy trial
The synergistic pesticidal action of the inventive mixtures can be demonstrated by the experiments below. A synergistic effect exists wherever the action of a combination (ready-mix) of active ingredient is greater than the sum of the action of each of the components alone. Therefore a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater fungicidal activity than the sum of the fungicidal activities of the individual components. In the field of agriculture, it is often understood that the term “synergy” is as defined by Colby S.R. in an article entitled “ Calculation of the synergistic and antagonistic responses of herbicide combinations” published in the journal Weeds, 1967, 15, p.20-22, incorporated herein by reference in its entirety. The action expected for a given combination of two active components can be calculated as follows:
Colby’s Formula :
XY
E = X + Y - -------
100
in which E represents the expected percentage of Insecticidal or fungicidal control for the combination of the two insecticide or fungicides at defined dose (for example equal to X and Y respectively), X is the percentage of insecticidal or fungicidal control observed by active ingredient I at defined dose (equal to X) and Y is the percentage of insecticidal or fungicidal control observed by Active Ingredient II (equal to Y). When the percentage of insecticidal or fungicidal control observed for the combination is greater than the expected percentage, there is a synergistic effect. (Ratio of O/E > 1, means synergism observed.).
Trial 1
To study the synergistic effect of Chlorantraniliprole with fungicides, Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole and Prothioconazole various sets of experiments were conducted in micro plot (4m x 2.5m). The paddy seedlings were transplanted (average 2 seedlings per hill) and raised as per the normal agronomic practices. The insects, Leaffolder Cnaphalocrosis medinalis and diseases Sheath blight Rhizoctonia solani were allow to build up, multiply and establish on paddy seedlings. Two sprays were applied with knapsack sprayer with 500 liter water per hectare at 15 days interval at 50 and 65 days after transplanting the seedlings in to micro plots. Each treatment was replicated 3 times. The assessment was done by counting the number of insect at before and 10 days after spraying. The percent insect control calculated as below:

% Insect control = 100 – 100 x (Number of insect observed in treated / Number of Insect in Untreated check.

The synergistic effect was calculated by Colby’s formula.
The observations on sheath blight disease severity were recorded at 10 days after foliar application and percent disease index calculated by below formula. The percent disease controls were calculated by disease severity in untreated plot.
Assessment for Sheath Blight :
Observed 100 tillers per plot and rated visually as per the ratings below.
Score Description
0 No infection
1 Vertical spread of the disease up to 20% of plant height
3 Vertical spread of the disease up to 21-30% of plant height
5 Vertical spread of the disease up to 31- 45% of plant height
7 Vertical spread of the disease up to 46 - 65% of plant height
9 Vertical spread of the disease more than 66% of plant height

Sum of numerical rating x 100
% Disease Index = --------------------------------------------------------------
Total number of tiller observed x Maximum rating

% Disease Control = 100–(100-Disease Index in treatment/Disease index in Untreated plot)

Table 1 : Synergistic effect of Chlorantraniliprole and fungicide on Paddy Leaffolder and Sheath blight control
Treatments % Leaf folder control Sheath blight Control (%)
Obs value Exp Value Ratio O/E Obs value Exp Value Ratio O/E
Chlorantraniliprole 60 ppm 87.2 0
Difenoconazole 150 ppm 0 64.8
Flusilazole 250 ppm 0 69.6
Cyproconazole 200 ppm 0 65.6
Epoxiconazole 200 ppm 0 75.4
Prothioconazole 250 ppm 0 69.2
Chlorantraniliprole+ Difenoconazole 60 +150ppm 98.6 87.2 1.13 77.2 64.8 1.19
Chlorantraniliprole+ Flusilazole 60+250 ppm 99.2 87.2 1.14 80.6 69.6 1.16
Chlorantraniliprole+ Cyproconazole 60+200 ppm 97.8 87.2 1.12 76.6 65.6 1.17
Chlorantraniliprole+ Epoxiconazole 60+200 ppm 98.4 87.2 1.13 83.2 75.4 1.10
Chlorantraniliprole+ Prothioconazole 60+250 ppm 98.8 87.2 1.13 82.6 69.2 1.19
A synergistic action of Chlorantraniliprole with one more fungicide from Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole or Prothioconazole has been observed in terms of Leaf folder and Sheath blight control as compared to their individual applications.

Trial 2
The desired concentration of Flubendiamide and fungicides mixture were sprayed on tomato plant in poly house with the help of knap sack sprayer. The plot size was taken as 1 plant and with 4 replications. The laboratory reared 2nd Instar, 5 larvae of fruit borer, Helicoverpa armigera were released per plant and allow to adapt the condition for 72 hrs before spraying. The lab culture of Early blight fungus, Alternaria solani also sprayed with hand atomizer allow to infect the tomato plant for 72 hrs. The larval mortality and PDI for Early blight were recorded at 4 days after spraying. The percent larval control and Percent disease control were calculated and presented in below table as observed value.

The Early blight disease severity calculated by below rating scale:
Score Symptoms
0 No symptom on the leaf
1 Small irregular brown spots covering 1% or less of the leaf area
3 Small, irregular, brown spots with concentric rings covering 1 – 10% of the leaf area
5 Lesions enlarging, irregular, brown with concentric rings, cover 11 – 25% of leaf area
7 Lesions coalesce to form irregular, dark brown patches with concentric rings covering 26 – 50% of leaf area. Lesions on stems and petioles
9 Lesions coalesce to form irregular, dark brown patches with concentric rings covering more than 51% of leaf area. Lesions on stems and petioles

Table 2 : Control of Fruit borer Helicoverpa armigera and Early Blight Alternaria solani on tomato
Treatments % Fruit borer control Early Blight Control (%)
Obs value Exp Value Ratio O/E Obs value Exp Value Ratio O/E
Flubendiamide 120 ppm 86.6 0
Difenoconazole 150 ppm 0 78.6
Flusilazole 250 ppm 0 77.2
Cyproconazole 200 ppm 0 80.4
Epoxiconazole 200 ppm 0 75.2
Prothioconazole 250 ppm 0 72.6
Flubendiamide+ Difenoconazole 120+150 ppm 96.2 86.6 1.11 92.4 78.6 1.18
Flubendiamide+ Flusilazole 120+250 ppm 97.4 86.6 1.12 90.4 77.2 1.17
Flubendiamide+ Cyproconazole 120+200 ppm 95.8 86.6 1.11 93.6 80.4 1.16
Flubendiamide+ Epoxiconazole 120+200 ppm 94.6 86.6 1.09 94.2 75.2 1.25
Flubendiamide+ Prothioconazole 120+250 ppm 96.2 86.6 1.11 91.6 72.6 1.26
Flubendiamide with one more fungicides from Difenoconazole, Flusilazole, Cyproconazole, Epoxiconazole or Prothioconazole shows synergistic action against Tomato fruit borer, Helicoverpa armigera and Early blight Alternaria solani control.

Trial 3
Cabbage (Brassica oleracea) leaf- discs are sprayed with a preparation of the active ingredient at the desired concentration. Once dry, the leaf discs are infested with larvae of the tobacco leaf eating caterpillar (Spodoptera litura). After the specified period of time, mortality in % is determined. 100 % means that all the caterpillars have been killed; 0 % means that none of the caterpillars have been killed. The mortality values thus determined are recalculated using the Colby-formula (as per Trial 1).

Table: 3 Test on Tobacco Leaf eating caterpillar, Spodoptera litura
Treatments % Spodoptera Larval control
Obs value Exp Value Ratio O/E
Flubendiamide,120 ppm 70.8
Azoxystrobin, 250 ppm 0
Flubendiamide + Azoxystrobin, 120+250 ppm 89.6 70.8 1.27

The combination of Flubendiamide and Azoxystrobin shows synergic effect on larval mortality of Spodoptera litura.
Trial 4
In Vitro study: The synergistic effect of compositions of Flubendiamide and Azoxystrobin on growth of the pathogen in vitro was studied by poison food technique. Different concentrations of active ingredients were prepared by dissolving the requisite quantity of each active ingredient in warm potato dextrose agar medium before autoclaving. After autoclaving the medium was then dispensed uniformly into 90 mm diameter petriplate and inoculated at the 2 mm mycelial discs of pathogen taken from 7 day old culture. Pathogen inoculated in unamended medium served as control. Each treatment was maintained in four replications. The inoculated plates were incubated at 28 +/- 2 C for 3 days and the diameter of the fungal colony was measured by measuring the two opposite circumference of the colony growth at 3 days interval for 15 days. The growth of fungus was monitored by measuring the radial growth (in mm) every 72 h till the fungus covers the plate completely in control plates. The percent inhibition (PI) of the fungus over the control was calculated using the following formula :

PI = A-B X 100/A
Where A= Colony diameter of fungus in control plates (mm)
B= Colony diameter of fungus in treated plates (mm)
The synergistic pesticidal action of the inventive mixtures calculated as follows:
For mixture of two active ingredients,
E = [ A + B] – [AB/ 100]
in which,
E = Expected percentage of Insecticidal or fungicidal control for the combination of three active ingredient,
A is the percentage of insecticidal or fungicidal control observed by active ingredient I at defined dose,
B is the percentage of insecticidal or fungicidal control observed by Active Ingredient II at defined dose, When the percentage of insecticidal or fungicidal control observed for the combination is greater than the expected percentage, there is a synergistic effect. (Ratio of O/E > 1, means synergism observed.)

Table 4 : Effect of Flubendiamide+Azoxystrobin combination on growth inhibition of Aspergillus niger
Treatments % Growth Inhibition of
Aspergillus niger
Obs value Exp Value Ratio O/E
Flubendiamide, 50 ppm 6.26
Azoxystrobin, 100 ppm 68.82
Flubendiamide +Azoxystrobin, 50+100 ppm 94.32 70.8 1.33

In vitro studies show that the synergism was observed between Flubendiamide+Azoxystrobin in terms of excellent suppressive effect on radial growth of Aspergillus niger.
,CLAIMS:We claim;
1. A pesticidal composition comprising an Anthranilamide selected from Flubendiamide or Chlorantraniliprole and at least one fungicide, wherein fungicide is selected from Azoxystrobin, Difenoconazole, Flusilazole, Cyproconazole, Prothioconazole and Epoxiconazole and one or more inactive excipients, with the proviso that Azoxystrobin is not combined with Chlorantraniliprole.

2. A pesticidal composition as claimed in claim 1, wherein the ratio of Anthranilamide and at least one fungicide, wherein fungicide is 1:10 to 10:1.

3. A pesticidal composition as claimed in claim 1-2, wherein inactive excipients is selected from the group consisting of dispersant, anti-freezing agent, anti-foam agent, wetting agent, suspension aid, anti-microbial agent, thickener, quick coating agent or sticking agents and buffering agent.

4. A pesticidal composition as claimed in claim 1-3, wherein the composition are selected from wettable powder (WP), Water dispersible granules (WG/WDG), soil applied granules (SAG), dustable powder (DP), a gel, a wettable powder (WP), a granule (GR) (such as an emulsifiable granule (EG) or more particularly a water-dispersible granule (WG)), a water-dispersible tablet (WT), an emulsifiable concentrate (EC), a micro- emulsifiable concentrate, an oil-in-water emulsion (EW), an oil flowable (e.g. a spreading oil (SO)), an aqueous dispersion (e.g. aqueous suspension concentrate (SC)), an oily dispersion (OD), a suspo-emulsion (SE), a capsule suspension (CS), a soluble liquid, a water-soluble concentrate (with water or a water-miscible organic solvent as carrier), an impregnated polymer film, Flowable Slurry (FS) / Flowable Suspension(FS) / Suspension Concentrate (SC), Water dispersible powder for slurry seed treatment (WS), ZC ( A mixed formulation of CS and SC), ZE (A mixed heterogeneous formulation of CS and SE), ZW( A mixed heterogeneous formulation CS and EW) having synergistic effect.

5. A pesticidal composition as claimed in claim 1, wherein the composition to be used for crop selected from Cotton(Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Maize (Zea mays), Sorghum (Sorghum bicolor), Sugarcane (Saccharum officinarum) , Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus) , Green gram (Vigna radiate), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Chilly (Capsicum annum), Apple (Melus domestica), Grape (Vitis vinifera), Pomegranate (Punica granatum),Tea (Camellia sinensis) and its GMO derivatives.

6. A pesticidal composition claimed in claim 1 or 6, wherein the composition to be used control fungal disease including Wheat - Tilletia tritici, Neovossia indica, Puccinia triticina, Puccinia recondite, Erysiphe graminis, Blumeria graminis. Rice- Pyricularia oryzae, Ustilaginoidea virens, Rhizoctonia solani, Sclerotium rolfsii, Rhizoctonia solani, Maize : Anthracnose leaf blight, ear and kernel rot, Aspergillus flavus, Aspergillus niger, Fusarium kernel, root and stalk rot, seed rot and seedling blight Fusarium moniliforme, Peanut : Aspergillus crown rot Aspergillus niger, Cercospora arachidicola, Cercosporidium personatum, Rust Puccinia arachidis, Sclerotinia blight Sclerotinia minor, Sunflower- Alternaria leaf blight, stem spot and head rot Alternaria alternate, Cotton- Areolate mildew Ramularia gossypii, Boll rot Ascochyta gossypii , Colletotrichum gossypii, Leaf spot Alternaria macrospora, Capsicum spp -Anthracnose Colletotrichum gloeosporioides, C. capsici, Glomerella cingulata, Cercospora (frogeye) leaf spot Cercospora capsici, Damping-off and root rot Rhizoctonia solani, Phytophthora spp., Fusarium spp., Pythium spp., Powdery mildew Oidiopsis sicula, Leveillula taurica, Potato- Alternaria solani, Botrytis cinerea, Phytophthora infestans, Tomato- Alternaria alternate f. sp. Lycopersici, Phytophthora capsici, Stemphylium botryosum f. sp. Lycopersici, Phytophthora infestans, Apple- Aternaria mali, Venturia inaequalis, Marssonina blotch, Grape- Botrytis cinerea, Plasmopara viticola, Uncinula necator.

7. The pesticidal composition according to any proceeding claims, wherein the use of said composition exhibits improvement in plant health, vigor and yield.