Phenyl Alkanoic Acid Derivatives As Gpr Agonists

Abstract: The present invention relates to phenyl alkanoic acid derivatives (the compounds of Formula (I)); and their isotopic forms stereoisomeric and tautomeric forms and mixtures thereof in all ratios or pharmaceutically acceptable salts pharmaceutically acceptable solvates prodrugs polymorphs N oxides S oxides or carboxylic acid isosteres thereof. The invention also relates to processes for the preparation of compounds of Formula (I) and pharmaceutical compositions comprising one or more of the compounds of Formula (I). The said compounds and the pharmaceutical composition function as GPR (G protein coupled receptor) agonists particularly as GPR40 agonists and are useful in the treatment of diseases or conditions mediated by GPR40. The present invention further relates to a method of treatment of diseases or conditions mediated by GPR40comprising administering to a subject in need thereof a therapeutically effective amount of the compounds of Formula (I).

Patent Information

Application #

Filing Date

18 September 2014

Publication Number

27/2015

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

PIRAMAL ENTERPRISES LIMITED

Piramal Tower Ganpatrao Kadam Marg Lower Parel Mumbai 400013 India

Inventors

1. KUMAR Sanjay

1 Nirlon Complex Off Western Express Highway Goregaon (East) Mumbai 400063

2. SHARMA Rajiv

1 Nirlon Complex Off Western Express Highway Goregaon (East) Mumbai 400063

3. MAHAJAN Vishal Ashok

1 Nirlon Complex Off Western Express Highway Goregaon (East) Mumbai 400063

4. SAWARGAVE Sangameshwar Prabhakar

1 Nirlon Complex Off Western Express Highway Goregaon (East) Mumbai 400063

Specification

Documents

Application Documents

#	Name	Date
1	1839-MUMNP-2014-AbandonedLetter.pdf	2018-12-04
1	1839-MUMNP-2014-CORRESPONDENCE(16-10-2014).pdf	2014-10-16
2	1839-MUMNP-2014-ANNEXURE TO FORM 3(16-10-2014).pdf	2014-10-16
2	1839-MUMNP-2014-Correspondence-040416.pdf	2018-08-11
3	Other Patent Document [04-03-2017(online)].pdf	2017-03-04
3	1839-MUMNP-2014-Correspondence-161214.pdf	2018-08-11
4	PCTIB2013051555-IB 304 - PRIORITY DOCUMENT.pdf	2018-08-11
4	1839-MUMNP-2014-Correspondence-280115.pdf	2018-08-11
5	GPA of Piramal Enterprises Limited.pdf	2018-08-11
5	1839-MUMNP-2014-FER.pdf	2018-08-11
6	Form-18(Online).pdf	2018-08-11
6	1839-MUMNP-2014-Form 3-040416.pdf	2018-08-11
7	FORM 5.pdf	2018-08-11
7	1839-MUMNP-2014-Form 3-161214.pdf	2018-08-11
8	FORM 3.pdf	2018-08-11
8	1839-MUMNP-2014-OTHERS-040416.pdf	2018-08-11
9	1839-MUMNP-2014-OTHERS-280115.pdf	2018-08-11
9	FORM 2 - COMPLETE SPECIFICATON AS FILED.pdf	2018-08-11
10	1839-MUMNP-2014.pdf	2018-08-11
10	ABSTRACT1.jpg	2018-08-11
11	1839-MUMNP-2014.pdf	2018-08-11
11	ABSTRACT1.jpg	2018-08-11
12	1839-MUMNP-2014-OTHERS-280115.pdf	2018-08-11
12	FORM 2 - COMPLETE SPECIFICATON AS FILED.pdf	2018-08-11
13	1839-MUMNP-2014-OTHERS-040416.pdf	2018-08-11
13	FORM 3.pdf	2018-08-11
14	1839-MUMNP-2014-Form 3-161214.pdf	2018-08-11
14	FORM 5.pdf	2018-08-11
15	1839-MUMNP-2014-Form 3-040416.pdf	2018-08-11
15	Form-18(Online).pdf	2018-08-11
16	1839-MUMNP-2014-FER.pdf	2018-08-11
16	GPA of Piramal Enterprises Limited.pdf	2018-08-11
17	1839-MUMNP-2014-Correspondence-280115.pdf	2018-08-11
17	PCTIB2013051555-IB 304 - PRIORITY DOCUMENT.pdf	2018-08-11
18	Other Patent Document [04-03-2017(online)].pdf	2017-03-04
18	1839-MUMNP-2014-Correspondence-161214.pdf	2018-08-11
19	1839-MUMNP-2014-Correspondence-040416.pdf	2018-08-11
19	1839-MUMNP-2014-ANNEXURE TO FORM 3(16-10-2014).pdf	2014-10-16
20	1839-MUMNP-2014-CORRESPONDENCE(16-10-2014).pdf	2014-10-16
20	1839-MUMNP-2014-AbandonedLetter.pdf	2018-12-04

Search Strategy

1	SEARCHSTRATEGY_17-05-2018.pdf