PHOTOPROTECTIVE COMPOSITION
The present invention relates to a photoprotective composition for topical use containing
an association of baicalin or an extract containing same with at least one system filtering
UVA radiation. The invention particularly relates to the field of cosmetics and/or beauty
products.
The present invention also relates to the cosmetic, non-therapeutic, use of baicalin, or
an extract containing same, in association with at least one system filtering UVA
radiation comprising at least one bis-resorcinyl triazine for protecting the skin and/or lips
and/or hair against solar radiation.
It is known that UV-A rays, having wavelengths between 320 and 400 nm, which cause
the skin to tan, are liable to induce damage thereof, particularly in the case of sensitive
skin or skin continually exposed to solar radiation. UV-A rays particular cause a loss of
skin elasticity and the appearance of wrinkles giving rise to premature skin ageing. In
this way, for esthetic and cosmetic reasons, such as preserving natural skin elasticity,
for example, an increasing number of people are seeking to control the effect of UV-A
rays on their skin. It is thus desirable to filter UV-A radiation.
It is also known that light radiation with wavelengths between 280 nm and 400 nm
enables tanning of the human epidermis, and that rays having wavelengths more
specifically between 280 and 320 nm, known as UV-B, impede the development of a
natural tan. For these reasons and for esthetic reasons, there is a constant demand for
means for controlling natural tanning with a view to controlling skin color; it is thus
necessary to filter UV-B radiation.
In order to protect the skin and keratin material against UV radiation, sunscreen
compositions comprising organic filters, active in the UV-A range and active in the UV-B
range, are generally used. The majority of these filters are lipophilic, although they also
include hydrophilic compounds.
State of the related art
There is scope for further enhancement of existing photoprotective compositions in
respect of protecting the skin against UV radiation, particularly in respect of UVA, but
also UVB, radiation.
The development of cosmetic compositions suitable for combating premature skin
ageing effectively involves the use of sun filters, particularly those absorbing in the UVA
range. These filters make it possible to reduce excess photoinduced free radicals.
However, with the majority of compositions containing UV filters, particularly UVA filters,
complete protection is not provided. In this way, following repeated exposure, the
residual amount of free radicals persisting in spite of UVA filter protection may, in the
long-term, cause photoactinic ageing phenomena. One solution may consist of
increasing the amounts of UVA filters, but it is not recommended to use excessively
high levels of filters in cosmetic products for everyday use.
Indeed, with the majority of filters, a maximum protection factor is reached, which is very
difficult to improve by increasing the proportion of filters.
In this way, research on solutions, aiming to find a means other than that consisting of
using large amounts of UV filters, particularly UVA filters, for protecting the skin against
sun rays and combating premature skin ageing effectively under conditions of use and
in concentrations acceptable for those skilled in the art, is still of interest.
In the prior art, the use of baicalin in cosmetic compositions, and particularly in
photoprotective compositions, has already been suggested. This particularly stems from
a number of publications and patents such as the patent application JP 63083017
relating to the filtering action of some compounds including baicalin.
The publications by Shengzhao et al. (Study of application of baicalin in functional
cosmetics, Shengzhao Gong; Yuke Jie; Shuiming Yuan, Riyong Huaxue Gongye (2003),
33(3), 200-203) and Feng-jiao et al. (Technology for preparation of sunscreen cream
containing baicalin, Feng-jiao Sun; Ke-jian Liao; Yu-feng Cong; Yue-ling Dai; Feng Yan,
Riyong Huaxue Gongye (2009), 39(4), 257-259) also relate to cosmetic compositions, and
more specifically sun protection compositions, containing baicalin.
The patent application DE1 02009037900 also describes a cosmetic composition
comprising baicalin in association with various active ingredients. This document also
describes the possible additional presence of UV filtering agents, but with no particular
conclusion in this respect.
The international application WO 98/196651 describes a composition comprising mineral
(non-chemical) filters in the presence of proanthocyanidins, ferulic acid oryzanol and/or an
ester containing same and optionally a Scutellaria extract. The possibility of using baicalin
is mentioned; however, it is clear from the examples that the very specific association of
ethyl ferulate, pycnogenol, oryzanol and Scutellaria extract improves the skin protection
factor (SPF). However, these photoprotective compositions comprising baicalin require
further enhancement in terms of protecting the skin against solar radiation, particularly UV.
There is thus still a need to identify compositions, particularly cosmetic compositions
protecting the skin against damage induced by sun rays.
Aims of the invention
The aim of the invention is that of solving the technical problem consisting of providing a
photoprotective composition for topical use and particularly a cosmetic composition.
The aim of the invention is also that of solving the technical problem consisting of
improving photoprotective compositions in terms of protection of the skin and/or hair
and/or lips against solar radiation, particularly UV.
A further aim of the invention is that of finding a means other than that consisting of
using large amounts of UV filters, particularly UVA filters, for combating premature
ageing of the skin and/or lips and/or hair effectively under conditions of use and in
concentrations acceptable for those skilled in the art.
A further aim of the invention is that of preventing and/or combating premature ageing of
the skin and/or lips due to ultraviolet radiation and protecting the skin and/or lips and/or
hair against this form of radiation and free radicals.
The invention thus proposes to solve these various technical problems
Description of the invention
The Applicant has now discovered, surprisingly, that, by associating baicalin, or an
extract containing same, with at least one system filtering UVA radiation comprising at
least one bis-resorcinyl triazine derivative, it was possible to enhance the protection of
the skin and/or lips and/or hair against UV, particularly in respect of UVA radiation.
In this way, according to one of the aims of the present invention, a photoprotective
composition for topical use comprising baicalin or an extract containing same, and at
least one system filtering UVA radiation comprising at least one bis-resorcinyl triazine
derivative. The invention particularly relates to a cosmetic composition. The system
filtering UVA radiation advantageously further comprises at least one UVA filter selected
from a dibenzoylmethane derivative, a compound filtering UVA derived from
benzylidene camphor and a mixture of these two types of derivatives.
According to one preferred embodiment, the composition according to the invention
further comprises at least one UVB filter, particularly of the b,b'-diphenylacrylate type.
The composition according to the invention more specifically covers a composition
comprising baicalin, or an extract containing same; at least one system filtering UVA
radiations comprising at least one bis-resorcinyl triazine derivative, at least one
dibenzoylmethane derivative, and at least one compound filtering UVA derived from
benzylidene camphor; and at least one UVB filter particularly of the b,b'-diphenylacrylate
type, and preferably a composition comprising baicalin, or an extract containing same;
and at least one system filtering UVA radiations comprising at least Bis-
Ethylhexylphenol Methoxyphenyltriazine, Avobenzone, Terephthalylidene Dicamphor
Sulfonic Acid; said composition further comprising octocrylene.
The composition according to the invention more specifically further comprises
compounds filtering UVA and/or UVB. The composition according to the invention
preferably further comprises cosmetically acceptable excipients.
The invention also relates to a multi-constituent agent for the photoprotection of human
keratin material (skin, lips, hair, eyelashes, eyebrows, nails) comprising a composition A
and a composition B packaged separately; said composition A comprising, in a
cosmetically acceptable medium, at least baicalin or an extract;
said composition B comprising, in a cosmetically acceptable medium, at least one
system filtering UVA radiation comprising at least one bis-resorcinyl triazine derivative;
said composition A and said composition B being applied either simultaneously or
sequentially on the surface of the keratin material.
In the case of sequential application, composition A comprising baicalin is preferably
applied first. The time interval between the applications of composition A and
composition B preferably varies from 1 hour to 48 hours and more preferentially from 1
hour to 24 hours. The filtering composition B could be applied immediately prior to UV
and particularly solar radiation exposure.
The system filtering UVA radiation advantageously further comprises at least one UVA
filter selected from a dibenzoylmethane derivative, a compound filtering UVA derived
from benzylidene camphor and a mixture of these two types of derivatives.
Composition B according to the invention specifically contains at least one system
filtering UVA radiation comprising at least one bis-resorcinyl triazine derivative, at least
one dibenzoylmethane derivative, and at least one compound filtering UVA derived from
benzylidene camphor.
According to one preferred embodiment, the composition according to the invention
further comprises at least one UVB filter, particularly of the b,b'-diphenylacrylate type.
According to one preferred embodiment, composition B according to the invention
comprises at least one system filtering UVA radiation comprising at least Bis-
Ethylhexylphenol Methoxyphenyltriazine, Avobenzone, Terephthalylidene Dicamphor
Sulfonic Acid; said composition further comprising octocrylene.
Composition B according to the invention more specifically further comprises
compounds filtering UVA and/or UVB. The composition according to the invention
preferably further comprises cosmetically acceptable excipients.
A further aim of the invention relates to the cosmetic, non-therapeutic, use of baicalin, or
an extract containing same, in association with at least one system filtering UVA
radiation comprising at least one bis-resorcinyl triazine for protecting the skin and/or lips
and/or hair against solar radiation, and/or for combating or preventing photoinduced
premature ageing of the skin and/or lips and/or hair.
The present invention also relates to a cosmetic and/or beauty treatment method
comprising the topical application on human keratin material (skin, lips, hair, eyelashes,
eyebrows, nails) of a composition or a multi-constituent agent according to the
invention, for combating or preventing photoinduced premature ageing of human keratin
material (skin, lips, hair, eyelashes, eyebrows, nails).
The present invention also relates to a cosmetic and/or beauty treatment method
comprising the topical application on human keratin material (skin, lips, hair, eyelashes,
eyebrows, nails) of a composition or a multi-constituent agent as defined, for protecting
the human keratin material (skin, lips, hair, eyelashes, eyebrows, nails) against solar
radiation.
Further features, aspects and advantages of the invention will emerge on reading the
detailed description hereinafter.
Definitions
The term system filtering UV (UVA and/or UVB) radiation refers to a substance capable
of absorbing at least a portion of UV (UVA and/or UVB) radiation emitted by the sun for
protecting the skin and/or lips and/or hair against the harmful effects of this radiation.
UVA radiation wavelengths are different to UVB radiation wavelengths. UVA radiation
wavelengths are between 400 nm and 315 nm and for UVB between 315 nm and
280 nm.
The term "associate" compounds or "association" of compounds refers to the presence,
in the same composition, or in separate compositions applied sequentially or
simultaneously, of the compounds to which reference is made.
The term "cosmetically acceptable" means compatible with the skin and/or integuments
thereof, having a pleasant color, odor and texture and not giving rise to unacceptable
discomfort (tingling, tightness, redness), liable to dissuade the consumer from using the
composition.
The compositions according to the invention, particularly compositions A and/or B, may
additionally comprise further complementary organic or inorganic UV filters active in the
UVA and/or UVB range, which are hydrophilic or lipophilic or insoluble in routine
cosmetic solvents.
The term "lipophilic UV filter" refers to any cosmetic or dermatological filter liable to be
completely dissolved in the molecular state in a liquid fat phase or be solubilized in
colloidal form (for example in micellar form) in a liquid fat phase.
The term "hydrophilic UV filter" refers to any cosmetic or dermatological filter liable to be
completely dissolved in the molecular state in a liquid aqueous phase or be solubilized
in colloidal form (for example in micellar form) in a liquid aqueous phase.
The term "insoluble UV filter" refers to any cosmetic or dermatological filter which is not
defined as a lipophilic UV filter or as a hydrophilic UV filter, in particle form in liquid
aqueous or fat phase.
Detailed description of the invention
The invention is detailed hereinafter with reference to the more general description of the
invention.
Baicalin has the following formula:
Baicalin is available from MMP or Guilin Layn Natural Ingredients Corp. for example. This
compound is particularly described in the application WO 2008/140440 particularly in
stable solution form. Baicalin may be used in stable solution form comprising a glycol alkyl
having 2 to 7 carbon atoms, a polyol ether, and at least one anti-oxidant.
Such an organic compound may be obtained as described in EP 1 400 579
(US2004/0067894) relating to the synthesis of tetrahydroxyflavones wherein the general
formula comprises baicalin.
Baicalin may be used in the form of an extract of plant origin. Baicalin is a polyphenol
(flavone) particularly extracted from skull cap root (Scutellaria and particularly Scutellaria
baicalensis), based on traditional Chinese medicine.
The bis-resorcinyl triazine compounds according to the present invention preferably
comply with the followin formula (I):
in which:
(i) the radicals R and R2, which are identical or different, refer to a C3-C 8 alkyl radical;
C2-C 8 alkenyl radical or a residue having the formula -CH2-CH(OH)-CH 2-OT where T
a hydrogen atom or a C C8 alkyl radical;
(ii) the radicals R and R2, which are identical or different, may also refer to a residue
having the following formula ( 1) :
in which:
- R6 refers to a covalent bond; a C1-C4 linear or branched alkyl radical or a residue having
the formula -Cm H2mi-0- where m is a number from 1 to 4;
- P is a number from 0 to 5;
- the radicals R7, R8 et R9, which are identical or different, refer to a
C1-C18 alkyl radical; a C -C 8 alkoxy radical or a residue having the formula:
R10
O Si— R (2)
10
R10
where R 0 is a C-|-C5 alkyl radical;
- A refers to a residue complyin with any of the following formulas:
in which:
- R3 refers to a hydrogen atom, a C-I-C-IO alkyl radical, a radical having the formula:
- (CH2CHR5-0) R4 where n i is a number from 1 to 16, or a residue having the structure
- CH2-CH-(OH)-CH 2OT where T has the same meaning as mentioned above.
- R4 refers to hydrogen, a metal cation M, a C C5 alkyl radical or a residue having the
formula -(CH 2)m2-OT where m2 is a number from 1 to 4 and T has the same meaning as
mentioned above.
- Qi is a CrC 18 alkyl radical.
In formulas (I) and (1) to (5) described above:
- the alkyl radicals are linear or branched and may be selected for example from methyl,
ethyl, n-propyl, isopropyl, n-butyl, sec. butyl, tert.butyl, amyl, isoamyl, tert.amyl, heptyl,
octyl, isooctyl, nonyl, decyl, undecyl, dodecyl, tetradecyl, pentadecyl, hexadecyl,
heptadecyl or octadecyl;
- the alkenyl radicals may be selected for example from allyl, methallyl, isopropenyl, 2-
butenyl, 3-butenyl, isobutenyl, n-penta-2,4-dienyl, 3-methyl-but-2-enyl, n-oct-2-enyl, ndodec-
2-enyl, iso-dodecenyl, n-octadec-4-enyl;
- the alkoxy radicals are linear or branched and may be selected for example from
methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, sec.-butoxy, tert.-butoxy, amyloxy,
isoamyloxy or tert. amyloxy;
- the C -C5 mono or dialkylamino radicals may be selected for example from
methylamino, ethylamino, propylamino, n-butylamino, sec.butylamino, tert.butylamino,
pentylamino, dimethylamino, diethylamino, dibutylamino or methylethylamino.
- the metallic cations are alkaline, alkaline-earth or metallic cations selected for example
from lithium, potassium, sodium, calcium, magnesium, copper and zinc.
The bis-resorcinyl triazine derivatives having formula (I) according to the invention are
filters already known per se. They are described and prepared according to the synthesis
processes given in the patent applications EP-A-0775 698.
Examples of compounds having formula (I) suitable for use include:
- 2,4-bis {[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxy-phenyl)-1 ,3,5-triazine;
- 2,4-bis{[4-(3-(2-propyloxy)-2-hydroxy-propyloxy)-2-hydroxy]-phenyl}-6-(4-
methoxyphenyl)-1 ,3,5-triazine;
- 2,4-bis {[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-[4-(2-methoxyethyl-carboxyl)-
phenylamino]-1 ,3,5-triazine;
- 2,4-bis {[4-tris(trimethylsiloxy-silylpropyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-
1,3,5-triazine;
- 2,4-bis {[4-(2"-methylpropenyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1 ,3,5-
triazine;
- 2,4-bis {[4-(1 ',1',1',3',5',5',5'-heptamethyltrisiloxy-2"-methylpropyloxy)-2-hydroxy]-
phenyl}-6-(4-methoxyphenyl)-1 ,3,5-triazine.
- 2,4-bis{[4-(3-(2-propyloxy)-2-hydroxy-propyloxy]-2-hydroxy]-phenyl}-6-[(4-
ethylcarboxyl)-phenylamino]-1 ,3,5-triazine;
- 2,4-bis {[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(1-methylpyrrol-2-yl)-1 ,3,5-triazine.
More specifically, at least the compound 2,4-bis {[4-(2-ethyl-hexyloxy)-2-hydroxy]-
phenyl}-6-(4-methoxy-phenyl)-1 ,3,5-triazine or Bis-Ethylhexyloxyphenol Methoxyphenyl
Triazine (INCI name) such as the product sold under the trade name "TINOSORB S" by
CIBA GElGY.
The bis-resorcinyl triazine compound(s) having formula (I) are generally present in the
filtering compositions according to the invention at a concentration ranging from 0.1 to
20% by weight and more preferentially from 1 to 10% by weight and more specifically
from 2 to 8% by weight with respect to the total weight of the composition.
The dibenzoylmethane derivatives particularly include, but are not limited to:
- 2-methyldibenzoylmethane,
- 4-methyldibenzoylmethane,
- 4-isopropyldibenzoylmethane,
- 4-tert.-butyldibenzoylmethane,
- 2,4-dimethyldibenzoylmethane,
- 2,5-dimethyldibenzoylmethane,
- 4,4'-diisopropyldibenzoylmethane,
- 4,4'-dimethoxydibenzoylmethane,
- 4-tert.-butyl-4'-methoxydibenzoylmethane,
- 2-methyl-5-isopropyl-4'-methoxydibenzoylmethane,
- 2-methyl-5-tert-butyl-4'-methoxydibenzoylmethane,
- 2,4-dimethyl-4'-methoxydibenzoylmethane,
- 2,6-dimethyl-4-tert-butyl-4'-methoxydibenzoylmethane.
Of the dibenzoylmethane derivatives mentioned above, 4-isopropyl-dibenzoylmethane,
sold under the trade name "EUSOLEX 8020" by MERCK, and complying with the
formula below is used for example:
Particular preference is placed on the use of at least 4-(ter.-butyl) 4'-methoxy
dibenzoylmethane or Butyl Methoxy Dibenzoylmethane or avobenzone, marketed under
the trade name "PARSOL 1789" by DSM Nutritional Products, Inc; this filter complies
with the following formula:
The dibenzoylmethane derivative(s) may be present in the compositions according to
the invention at contents preferably varying from 0.01 to 10% by weight and more
preferentially from 0.1 to 6% by weight with respect to the total weight of the
composition.
The benzylidene camphor derivatives include:
3-Benzylidene camphor manufactured under the name "MEXORYL SD" by CHIMEX,
4-Methylbenzylidene camphor sold under the name "EUSOLEX 6300" by MERCK,
Benzylidene Camphor Sulfonic Acid manufactured under the name "MEXORYL SL" by
CHIMEX,
Camphor Benzalkonium Methosulfate manufactured under the name "MEXORYL SO"
by CHIMEX,
Polyacrylamidomethyl Benzylidene Camphor manufactured under the name "MEXORYL
SW" by CHIMEX.
The use of at least Terephthalylidene Dicamphor Sulfonic Acid marketed under the
name MEXORYL SX by CHIMEX is preferred.
The invention may further comprise at least one UVB filter and particular at least one b,
b'-diphenylacrylate derivative. Lipophilic UVB filters are preferred.
The b ,b '-diphenylacrylate derivatives include etocrylene, particularly sold under the
trade name "UVINUL N35" by BASF. The use of at least octocrylene as a UVB filter is
preferred. Octocrylene is particularly sold under the trade name "UVINUL N539" by
BASF.
The compositions according to the invention may additional comprise complementary
organic or inorganic photoprotective agents, also known as filtering agents or filters,
filtering wavelengths within the UVA and/or UVB ranges, which are hydrophilic or lipophilic
or insoluble in routine cosmetic solvents.
The complementary organic filters are particularly selected from anthranilics; cinnamic
derivatives; salicylic derivatives; benzophenone derivatives; phenyl
benzotriazole derivatives; benzalmalonate derivatives particularly those cited in the
patent US5624663; phenyl benzimidazole derivatives; imidazolines; 4,4-diarylbutadiene
derivatives; bis-benzoazolyle derivatives as described in the patents EP669323 and US
2,463,264; p-aminobenzoic acid (PABA) derivatives; methylene bis-(hydroxyphenyl
benzotriazole) derivatives as described in the applications US5,237,071 , US 5,166,355,
GB2303549, DE 197 26 184 and EP8931 19; benzoxazole derivatives as described in
the patent applications EP0832642, EP1 027883, EP1300137 and DE1 0 162844; filter
polymers and filter silicones such as those particularly described in the application WO-
93/04665; dimers derived from a-alkylstyrene such as those described in the patent
application DE1 9855649; 4,4-diarylbutadienes as described in the applications
EP0967200, DE1 9746654, DE1 9755649, EP-A-1 008586, EP1 133980 and EP1 33981 ;
merocyanine derivatives such as those described in WO04006878, WO05058269 and
WO06032741 and the mixtures thereof.
Examples of organic UV filters include those referred to hereinafter using the INCI name
thereof:
Classification according to UVA and/or UVB radiation wavelength range
I/ Lipophilic UV-A filters
Dibenzoylmethane derivatives:
Isopropyl Dibenzoylmethane;
Aminobenzophenones:
n-hexyl 2-(4-diethylamino-2-hydroxybenzoyl)-benzoate particularly sold under the trade
name "UVINUL A +" by BASF;
1,1'-(1 ,4-piperazinediyl)bis[1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methanone
(CAS 919803-06-8)
Anthranilic derivatives:
Menthyl anthranilate particularly sold under the trade name "NEO HELIOPAN MA" by
SYMRISE;
4,4-diarylbutadiene derivatives:
1,1-dicarboxy (2,2'-dimethyl-propyl)-4,4-diphenylbutadiene;
Merocvanine derivatives:
Octyl-5-N,N-diethylamino-2-phenysulfonyl-2,4-pentadienoate;
Within the scope of the invention, and according to one particular embodiment, the
following lipophilic filters are used:
Butyl Methoxydibenzoylmethane
II/ Hvdrophilic UV-A filters
The bis-benzoazolyl derivatives as described in the patents EP 669 323, and US
2,463,264 and more specifically the compound Disodium Phenyl Dibenzimidazo tetrasulfonate
sold under the trade name "NEO HELIOPAN AP" by SYMRISE;
The preferred hydrophilic UVA filter is Terephthalylidene Dicamphor Sulfonic Acid.
III/ Lipophilic UV-B filters
Para-aminobenzoates:
Ethyl PABA;
Ethyl Dihydroxypropyl PABA;
Ethylhexyl Dimethyl PABA (ESCALOL 507 from ISP);
Salicylic derivatives:
Homosalate particularly sold under the name "Eusolex HMS" by Rona/EM Industries;
Ethylhexyl Salicylate particularly sold under the name "NEO HELIOPAN OS" by
SYMRISE;
Dipropyleneglycol Salicylate particularly sold under the name "DIPSAL" by SCHER;
TEA Salicylate sold under the name "NEO HELIOPAN TS" by SYMRISE;
Cinnamates
Ethylhexyl Methoxycinnamate particularly sold under the trade name "PARSOL MCX"
by DSM Nutritional Products, Inc.;
Isopropyl Methoxy cinnamate;
Isoamyl Methoxy cinnamate particularly sold under the trade name "NEO HELIOPAN E
1000" by SYMRISE;
Diisopropyl Methylcinnamate;
Cinnoxate;
Glyceryl Ethylhexanoate Dimethoxycinnamate;
b,b'-diphenylacrylate derivatives:
Etocrylene, particularly sold under the trade name "UVINUL N35" by BASF;
Benzylidene camphor derivatives:
3-Benzylidene camphor manufactured under the name "MEXORYL SD" by CHIMEX;
Methylbenzylidene camphor sold under the name "EUSOLEX 6300" by MERCK;
Polyacrylamidomethyl Benzylidene Camphor manufactured under the name "MEXORYL
SW" by CHIMEX;
Triazine derivatives:
Ethylhexyl triazone particularly sold under the trade name "UVINUL T150" by BASF;
Diethylhexyl Butamido Triazone particularly sold under the trade name "UVASORB
HEB" by SIGMA 3V;
2,4,6-tris(dineopentyl 4'-amino benzalmalonate)-s-triazine;
2,4,6-tris(diisobutyl 4'-amino benzalmalonate)-s- triazine;
2,4-bis(dineopentyl 4'-amino benzalmalonate)-6-(n-butyl 4'-aminobenzoate)-s-triazine;
2,4-bis(n-butyl 4'-amino benzoate)-6-(aminopropyltrisiloxane)-s-triazine;
the symmetrical triazine filters described in the patent US 6,225,467, the application WO
2004/085412 (see compounds 6 and 9) or the document "Symmetrical Triazine
Derivatives" IP.COM Journal, IP.COM INC WEST HENRIETTA, NY,
US (September 20, 2004) particularly 2,4,6-tris-(biphenyl)-1 ,3,5-triazine (particularly
2,4,6-tris(biphenyl-4-yl-1 ,3,5-triazine) and 2,4,6-tris(terphenyl)-1 ,3,5-triazine, the latter
two filters being described in the BEIERSDORF applications WO 06/035000, WO
06/034982, WO 06/034991 ,WO 06/035007, WO 2006/034992, WO 2006/034985).
Imidazoline derivatives:
Ethylhexyl Dimethoxybenzylidene Dioxoimidazoline Propionate,
Benzalmalonate derivatives:
Polyorganosiloxanes with a benzalmalonate function such as Polysilicone-15
particularly sold under the trade name "PARSOL SLX" by DSM Nutritional Products,
Inc.;
Di-neopentyl 4'-methoxybenzalmalonate;
Within the scope of the invention, and according to one particular embodiment, the
following lipophilic UV-B filters are used in the composition according to the invention:
Ethylhexylsalicylate;
Octocrylene;
Ethylhexyl triazone.
IV/ Hvdrophilic UV-B filters
The following p-aminobenzoic acid (PABA) derivatives:
PABA,
Glyceryl PABA and
PEG-25 PABA particularly sold under the trade name "UVINUL P25" by BASF.
Phenylbenzimidazole Sulfonic Acid particularly sold under the trade name
"EUSOLEX 232" by MERCK,
ferulic acid,
salicylic acid,
DEA methoxycinnamate,
Benzylidene Camphor Sulfonic Acid manufactured under the name "MEXORYL SL" by
CHIMEX,
Camphor Benzalkonium Methosulfate manufactured under the name "MEXORYL SO"
by CHIMEX,
The preferred hydrophilic UVB filter is Phenylbenzimidazole Sulfonic Acid.
V/ Combined lipophilic UVA and UVB filters
Benzophenone derivatives
Benzophenone-1 particularly sold under the trade name "UVINUL 400" by BASF;
Benzophenone-2 particularly sold under the trade name "UVINUL D50" by BASF;
Benzophenone-3 or Oxybenzone particularly sold under the trade name "UVINUL M40"
by BASF;
Benzophenone-6 particularly sold under the trade name "Helisorb 11" by Norquay;
Benzophenone-8 particularly sold under the trade name "Spectra-Sorb UV-24" by
American Cyanamid;
Benzophenone-10;
Benzophenone-1 1;
Benzophenone-12;
Phenyl benzotriazole derivatives:
Drometrizole Trisiloxane particularly sold under the name "Silatrizole" by RHODIA
CHIMIE or manufactured under the name "Meroxyl XL" by CHIMEX;
Methylene bis-Benzotriazolyl Tetramethylbutylphenol, sold in solid form particularly
under the trade name "MIXXIM BB/100" by FAIRMOUNT CHEMICAL or in micronized
form in aqueous dispersion particularly under the trade name "TINOSORB M" by CIBA
SPECIALTY CHEMICALS;
Benzoxazole derivatives:
2,4-bis-[5-1(dimethylpropyl)benzoxazol-2-yl-(4-phenyl)-imino]-6-(2-ethylhexyl)-imino-
1,3,5-triazine particularly sold under the name Uvasorb K2A by Sigma 3V.
The preferential lipophilic organic UVA and UVB filters are selected from:
Drometrizole Trisiloxane;
Methylene bis-Benzotriazolyl Tetramethylbutylphenol;
Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine.
VI/ Combined hydrophilic UVA and UVB filters
Benzophenone derivatives comprising at least one sulfonic radical such as
Benzophenone-4 particularly sold under the trade name "UVINUL MS 40" by BASF,
Benzophenone-5 and
Benzophenone-9.
The composition according to the invention may also comprise mineral filters which are
pigments. The pigments may be coated or uncoated.
The coated pigments are pigments which have undergone one or a plurality of chemical,
electronic, mechanochemical and/or mechanical surface treatments with compounds as
described for example in Cosmetics & Toiletries, February 1990, Vol. 105, p. 53-64,
such as amino acids, beeswax, fatty acids, fatty alcohols, anionic surfactants, lecithins,
sodium, potassium, zinc, iron or aluminum salts of fatty acids, metal (titanium or
aluminum) alkoxides, polyethylene, silicones, proteins (collagen, elastin),
alkanolamines, silicon oxides, metal oxides or sodium hexametaphosphate.
According to the prior art, the silicones are organosilicate polymers or oligomers with a
linear or cyclic, branched or cross-linked structure, with a variable molecular weight,
obtained by polymerization and/or polycondensation of suitably functionalized silanes,
and essentially consisting of a repetition of primary structural units wherein the silicon
atoms are interconnected by oxygen atoms (siloxane bond), optionally substituted
hydrocarbon radicals being directly bound via a carbon atom on said silicon atoms.
The term "silicones" also covers the silanes required for the preparation thereof,
particularly, alkyl silanes.
The silicones used for coating pigments suitable for the present invention are preferably
selected from the group containing alkyl silanes, polydialkylsiloxanes, and
polyalkylhydrogen siloxanes. More preferentially, the silicones are selected from the
group containing octyl trimethyl silane, polydimethylsiloxanes and polymethylhydrogen
siloxanes.
Obviously, prior to the treatment thereof with silicone, the metal oxide pigments may
have been treated with other surface agents, particularly cerium oxide, alumina, silica,
aluminum compounds, silicon compounds, or mixtures thereof.
The coated pigments are, for example, titanium oxides coated with:
- silica such as the product "SUNVEIL" from IKEDA and the product "Eusolex T-AVO"
from MERCK
- silica and iron oxide such as the product "SUNVEIL F" from IKEDA,
- silica and alumina such as the products "MICROTITANIUM DIOXIDE MT 500 SA" and
"MICROTITANIUM DIOXIDE MT 100 SA" from TAYCA, "TIOVEIL" from TIOXIDE, and
"Mirasun TiW 60" from Rhodia,
- alumina such as the products "TIPAQUE TTO-55 (B)" and "TIPAQUE TTO-55 (A)"
from ISHIHARA, and "UVT 14/4" from KEMIRA,
- alumina and aluminum stearate such as the product "MICROTITANIUM DIOXIDE
MT 100 TV, MT 100 TX, MT 100 Z, MT-01" from TAYCA, the products "Solaveil CT-10
W", "Solaveil CT 100" and "Solaveil CT 200" from UNIQEMA,
- silica, alumina and alginic acid such as the product "MT-100 AQ" from TAYCA,
- alumina and aluminum laurate such as the product "MICROTITANIUM DIOXIDE MT
100 S" from TAYCA,
- iron oxide and iron stearate such as the product "MICROTITANIUM DIOXIDE MT 100
F" from TAYCA,
- zinc oxide and zinc stearate such as the product "BR351" from TAYCA,
- silica and alumina and treated with a silicone such as the products "MICROTITANIUM
DIOXIDE MT 600 SAS", "MICROTITANIUM DIOXIDE MT 500 SAS" or
"MICROTITANIUM DIOXIDE MT 100 SAS" from TAYCA,
- silica, alumina, aluminum stearate and treated with a silicone such as the product
"STT-30-DS" from TITAN KOGYO,
- silica and treated with a silicone such as the product "UV-TITAN X 195" from KEMIRA,
or the product SMT-100 WRS from TAYCA.
- alumina and treated with a silicone such as the products "TIPAQUE TTO-55 (S)" from
ISHIHARA, or "UV TITAN M 262" from KEMIRA,
triethanolamine such as the product "STT-65-S" from TITAN KOGYO,
- stearic acid such as the product "TIPAQUE TTO-55 (C)" from ISHIHARA,
- sodium hexametaphosphate such as the product "MICROTITANIUM DIOXIDE MT
150 W" from TAYCA.
Further titanium oxide pigments treated with a silicone are for example Ti0 2 treated with
octyl trimethyl silane such as that sold under the trade name "T 805" by DEGUSSA
SILICES, Ti0 2 treated with a polydimethylsiloxane such as that sold under the trade
name "70250 Cardre UF Ti02SI3" by CARDRE, anatase/rutile Ti0 2 treated with a
polydimethylhydrogen siloxane such as that sold under the trade name "MICRO
TITANIUM DIOXYDE USP GRADE HYDROPHOBIC" by COLOR TECHNIQUES.
The uncoated titanium oxide pigments are for example sold by TAYCA under the trade
names "MICROTITANIUM DIOXIDE MT 500 B" or "MICROTITANIUM DIOXIDE MT600
B", by DEGUSSA under the name "P 25", by WACKHER under the name "Oxyde de
titane transparent PW", by MIYOSHI KASEI under the name "UFTR", by TOMEN under
the name "ITS" and by TIOXIDE under the name "TIOVEIL AQ".
The uncoated zinc oxide pigments are for example
- those marketed under the name "Z-cote" by Sunsmart;
- those marketed under the name "Nanox" by Elementis;
- those marketed under the name "Nanogard WCD 2025" by Nanophase Technologies;
The coated zinc oxide pigments are for example
- those marketed under the name "Z-COTE HP1" by SUNSMART (ZnO coated with
dimethicone);
- those marketed under the name "CS-5 zinc oxide" by Toshibi (ZnO coated with
polymethylhydrogen siloxane);
- those marketed under the name "Nanogard Zinc Oxide FN" by Nanophase
Technologies (in 40% dispersion in Finsolv TN, C12-C15 alcohol benzoate);
- those marketed under the name "DAITOPERSION ZN-30" and "DAITOPERSION Zn-
50" by Daito (dispersions in cyclopolymethylsiloxane/oxyethylenated
polydimethylsiloxane, containing 30% or 50% zinc oxides coated with silica and
polymethylhydrogen siloxane);
- those marketed under the name "NFD Ultrafine ZnO" by Daikin (ZnO coated
perfluoroalkyl phosphate and perfluoroalkylethyl-based copolymer in dispersion in
cyclopentasiloxane);
- those marketed under the name "SPD-Z1" by Shin-Etsu (ZnO coated with siliconegrafted
acrylic polymer, dispersed in cyclodimethylsiloxane);
- those marketed under the name "Escalol Z100" by ISP (ZnO treated with alumina and
dispersed in the ethylhexyl methoxycinnamate / PVP-hexadecene copolymer /
methicone mixture);
- those marketed under the name "Fuji ZnO-SMS-10" by Fuji Pigment (ZnO coated with
silica and polymethylsilsesquioxane);
- those marketed under the name "Nanox Gel TN" by Elementis (ZnO in 55% dispersion
in C12-C15 alcohol benzoate with hydroxystearic acid polycondensate).
The uncoated cerium oxide pigments are sold for example under the name
"COLLOIDAL CERIUM OXIDE" by RHONE POULENC.
The uncoated iron oxide pigments are for example sold by ARNAUD under the names
"NANOGARD WCD 2002 (FE 45B)", "NANOGARD IRON FE 45 BL AQ",
"NANOGARD FE 45R AQ, "NANOGARD WCD 2006 (FE 45R)", or by MITSUBISHI
under the name "TY-220".
The coated iron oxide pigments are for example sold by ARNAUD under the names
"NANOGARD WCD 2008 (FE 45B FN)", "NANOGARD WCD 2009 (FE 45B 556)",
"NANOGARD FE 45 BL 345", "NANOGARD FE 45 BL", or by BASF under the name
"TRANSPARENT IRON OXIDE".
It is also possible to cite metal oxide mixtures, particularly of titanium dioxide and cerium
dioxide, including the mixture of equal weights of titanium dioxide and cerium dioxide
coated with silica, sold by IKEDA under the name "SUNVEIL A", and the mixture of
titanium dioxide and zinc dioxide coated with alumina, silica and silicone such as the
product "M 261" sold by KEMIRA or coated with alumina, silica and glycerin such as the
product "M 2 11" sold by KEMIRA.
The pigments may be introduced into the compositions according to the invention as is or
in pigment paste form, i.e. in a mixture with a dispersion agent, as described for example
in the document GB-A-2206339.
The additional UV filters are generally present in the compositions according to the
invention in proportions ranging from 0.01 to 20% by weight with respect to the total
weight of the composition, and preferably ranging from 0.1 to 10% by weight with
respect to the total weight of the composition.
The composition may further comprise at least one additional ingredient intended to
provide an immediate visual effect. This particularly includes fillers with a soft-focus
effect or agents promoting naturally pink skin color.
Agents promoting naturally pink skin color include, for example, self-tanning agents, i.e.
an agent which, applied on the skin, particularly on the face, makes it possible to obtain
a tanning effect more or less similar to that liable to result from prolonged exposure to
the sun (natural tan) or a UV lamp;
Examples of self-tanning agents particularly include:
dihydoxyacetone (DHA),
erythrulose, and
the association of a catalytic system formed from:
manganese and/or zinc salts and oxides, and
alkaline and/or alkaline earth hydrogen carbonates.
The self-tanning agents are generally selected from mono or polycarbonyl compounds
such as for example isatin, alloxan, ninhydrin, glyceraldehyde, mesotartaric aldehyde,
glutaraldehyde, erythrulose, pyrazolin-4,5-dione derivatives as described in the patent
application FR 2 466 492 and WO 97/35842, dihydroxyacetone (DHA), 4,4-
dihydroxypyrazolin-5-one derivatives as described in the patent application EP 903 342.
DHA is preferably used.
DHA may be used in free and/or encapsulated form for example in lipid vesicles such as
liposomes, particularly described in the application WO 97/25970.
As a general rule, the self-tanning agent, particularly DHA, is present in an amount
ranging from 0.01 to 20 % by weight, and preferably in an amount between 0.1 and 10%
of the total weight of the composition.
Further colorants suitable for modifying the color produced by the self-tanning agent
may be used.
These colorants may be selected from synthetic or natural direct colorants.
These colorants may be selected for example from red or orange fluorane type
colorants such as those described in the patent application FR2840806. For example,
this includes the following colorants:
- tetrabromofluoroscein or eosin known as the CTFA name: CI 45380 or Red 2 1
- phloxine B known as the CTFA name: CI 45410 or Red 27
- diiodofluorescein known as the CTFA name CI 45425 or Orange 10;
- dibromofluorescein known as the CTFA name: CI 45370 or Orange 5.
- tetrabromofluoroscein sodium salt known as the CTFA name: CI 45380 (Na salt) or
Red 22
- phloxine B sodium salt known as the CTFA name: CI 45410 (Na salt) or Red 28
- diiodofluorescein sodium salt known as the CTFA name: CI 45425 (Na salt) or Orange
11;
- erythrosine known as the CTFA name: CI 45430 or Acid Red 5 1.
- phloxine known as the CTFA name: CI 45405 or Acid Red 98.
These colorants may also be selected from anthraquinones, caramel, carmine, carbon
black, azulene blues, methoxalene, trioxalene, guajazulene, chamuzulene, rose bengal,
cosine 10B, cyanosin, daphinin.
These colorants may also be selected from indole derivatives such as
monohydroxyindoles as described in the patent FR2651 126 (i.e.: 4-, 5-, 6- or 7-
hydroxyindole) or di-hydroxyindoles as described in the patent EP-B-0425324 (i.e.: 5,6-
dihydroxyindole, 2-methyl 5,6-dihydroxyindole, 3-methyl 5,6-dihydroxyindole, 2,3-
dimethyl 5,6-dihydroxyindole).
The compositions according to the present invention may further comprise conventional
cosmetic adjuvants particularly selected from fatty substances, particularly oils, waxes,
organic solvents, ionic or non-ionic thickeners, hydrophilic or lipophilic, softeners,
moistening agents, opacifiers, stabilizers, emollients, silicones, anti-foaming agents,
perfumes, preservatives, anionic, cationic, non-ionic, zwitterionic or amphoteric
surfactants, active substances, fillers, polymers, propellants, alkalinizing or acidifying
agents or any other ingredient routinely used in the cosmetic and/or dermatological field.
The fatty substances may consist of an oil or a wax or mixtures thereof. The term oil
refers to a liquid compound at ambient temperature. The term wax refers to a solid or
substantially solid compound at ambient temperature, wherein the melting point is
generally greater than 35.
The oils include, for example mineral oils (paraffin oil); vegetable oils (sweet almond,
macadamia, blackcurrant seed, jojoba); synthetic oils such as perhydrosqualene, fatty
alcohols, fatty amides (such as isopropyl lauroyi sarcosinate sold under the name
"Eldew SL-205" by Ajinomoto), fatty acids or esters such as C12-C15 alcohol benzoate
sold under the trade name "Finsolv TN" or "Witconol TN" by WITCO, 2-ethylphenyl
benzoate such as the commercial product sold under the name X-TEND 226 ® by ISP,
octyl palmitate, isopropyl lanolate, triglycerides including those of capric/caprylic acids,
dicaprylyl carbonate sold under the name "Cetiol CC" by Cognis), oxyethylene or
oxypropylene fatty esters and ethers; silicone oils (cyclomethicone,
polydimethysiloxanes or PDMS) or fluorinated oils, polyalkylenes, trialkyl trimellitates
such as tridecyl trimellitate.
The waxes include, for example, carnauba wax, beeswax, hydrogenated castor oil,
polyethylene waxes and polymethylene waxes such as that sold under the name
Cirebelle 303 by SASOL.
The organic solvents include, for example lower alcohols and polyols. These may be
selected from glycols and glycol ethers such as ethylene glycol, propylene glycol,
butylene glycol, dipropylene glycol or diethylene glycol.
The hydrophilic thickeners include, for example, carboxyvinyl polymers such as
Carbopols (Carbomers) and Pemulens (acrylate/C10-C30-alkylacrylate copolymer);
polyacrylamides such as for example cross-linked copolymers sold under the names
Sepigel 305 (C.T.F.A. name: polyacrylamide/C13-14 isoparaffin/Laureth 7) or Simulgel
600 (C.T.F.A. name: acrylamide / sodium acryloyldimethyltaurate copolymer /
isohexadecane / polysorbate 80) by Seppic; 2-acrylamido 2-methylpropane sulfonic acid
polymers and copolymers, optionally cross-linked and/or neutralized, such as poly(2-
acrylamido 2-methylpropane sulfonic acid) marketed by Hoechst under the trade name
"Hostacerin AMPS" (CTFA name: ammonium polyacryloyldimethyl taurate or
SIMULGEL 800 marketed by SEPPIC (CTFA name: sodium polyacryolyldimethyl
taurate / polysorbate 80 / sorbitan oleate); 2-acrylamido 2-methylpropane sulfonic acid
and hydroxyethyl acrylate copolymers such as SIMULGEL NS and SEPINOV EMT 10
marketed by SEPPIC; cellulose derivatives such as hydroxyethylcellulose;
polysaccharides and particularly gums such as Xanthan gum; hydrophilic or hydrodispersible
silicone derivatives such as acrylic silicones, silicone polyethers and cationic
silicones and mixtures thereof.
The lipophilic thickeners include, for example, synthetic polymers such as poly C10-C30
alkyl acrylates sold under the name "INTELIMER IPA 13-1" and "INTELIMER IPA 13-6"
by Landec or modified clays such as hectorite and derivatives thereof, such as the
products marketed under the names of Bentone.
Obviously, those skilled in the art would take care to select the optional complementary
compound(s) cited above and/or the amounts thereof such that the advantageous
properties intrinsically associated with the compositions according to the invention are
not, or substantially not, impaired by the envisaged addition(s), particularly the
enhancement in the protection of the skin and/or hair and/or lips against sun rays.
The compositions according to the invention may be prepared according to techniques
well-known to those skilled in the art. They may particularly be in the form of a simple or
complex emulsion (O/W, W/O, 0/W/O or W/O/W) such as a cream, milk or cream gel; in
the form of an aqueous gel; in the form of a lotion. They may optionally be packaged in
an aerosol and be presented in the form of a foam or spray.
The compositions according to the invention may be presented in the form of an oil-inwater
or water-in-oil emulsion.
The emulsification methods suitable for use are of the blade or impeller, rotor-stator and
HHP type.
It is also possible, by means of HHP (between 50 and 800 bar), to obtain stable
dispersions with droplet sizes as small as 100 nm.
The emulsions generally contain at least one emulsifying surfactant selected from
amphoteric, anionic, cationic or non-ionic emulsifying surfactants, used alone or in a
mixture. The emulsifiers are suitably selected according to the emulsion to be obtained
(W/O or O/W).
The emulsifying surfactants suitable for use for preparing W/O emulsions include, for
example, alkyl esters or sorbitan, glycerol or sugar ethers; silicone surfacants such as
dimethicone copolyols such as the mixture of cyclomethicone and dimethicone copolyol,
sold under the name "DC 5225 C" by Dow Corning, and alkyl-dimethicone copolyols
such as Laurylmethicone copolyol sold under the name "Dow Corning 5200 Formulation
Aid" by Dow Corning; Cetyl dimethicone copolyol such as the product sold under the
name Abil EM 90R by Goldschmidt and the mixture of cetyl dimethicone copolyol,
polyglycerol isostearate (4 moles) and hexyl laurate under the name ABIL WE 0 9 by
Goldschmidt. It is also possible to add one or a plurality of co-emulsifiers, which,
advantageously, may be selected from the group comprising polyol alkyl esters.
The polyol alkyl esters particularly include polyethyleneglycol esters such as PEG-30
Dipolyhydroxystearate such as the product marketed under the name Arlacel P135 by
ICI.
The glycerol and/or sorbitan esters include, for example, polyglycerol isostearate, such
as the product marketed under the name Isolan Gl 34 by Goldschmidt; sorbitan
isostearate, such as the product marketed under the name Arlacel 987 by ICI; sorbitan
isostearate and glycerol, such as the product marketed under the name Arlacel 986 by
ICI, and mixtures thereof.
For the O/W emulsions, the emulsifying surfactants include, for example, non-ionic
emulsifiers such as oxyalkylene (more specifically polyoxyethene) fatty acid and glycerol
esters; oxyalkylene fatty acid and sorbitan esters; oxyalkylene (oxyethylene and/or
oxypropylene) fatty acid esters such as the PEG-100 Stearate/Glyceryl Stearate mixture
marketed for example by ICI under the name Arlacel 165; oxyalkylene (oxyethylene
and/or oxypropylene) fatty alcohol ethers; sugar esters such as sucrose stearate; fatty
alcohol and sugar ethers, particularly alkylpolyglucosides (APG) such as decylglucoside
and laurylglucoside marketed for example by Henkel under the respective names
Plantaren 2000 and Plantaren 1200, cetostearylglucoside optionally in a mixture with
cetostearyl alcohol, marketed for example under the name Montanov 68 by Seppic,
under the name Tegocare CG90 by Goldschmidt and under the name Emulgade
KE3302 by Henkel, and arachidyl glucoside, for example in the form of the mixture of
arachidic and behenic alcohols and arachidylglucoside marketed under the name
Montanov 202 by Seppic. According to one particular embodiment of the invention, the
alkylpolyglucoside mixture as defined above with the corresponding fatty alcohol may be
in the form of a self-emulsifying composition, as described for example in the document
WO-A-92/06778.
In the case of an emulsion, the aqueous phase thereof may comprise a non-ionic
vesicular dispersion prepared according to known methods (Bangham, Standish and
Watkins. J. Mol. Biol. 13, 238 (1965), FR 2 315 991 and FR 2 416 008).
The compositions according to the invention may be applied in a large number of
treatments, particularly cosmetic treatments, of the skin, lips and/or hair, including the
scalp, particularly for protecting and/or treating the skin, lips and/or hair, and/or for
makeup for the skin and/or lips.
The cosmetic compositions according to the invention may for example by used as a
makeup product.
The cosmetic compositions according to the invention may for example be used as a
treatment and/or sun protection product for the face and/or body with a liquid to semiliquid
consistency, such as milks, more or less unctuous creams, cream gels, pastes.
They may optionally be packaged in an aerosol and be presented in the form of a foam
or spray.
The compositions according to the invention in the form of fluid lotions suitable for
vaporization according to the invention are applied on the skin or hair in the form of fine
particles by means of pressurization devices. The devices suitable for the invention are
well known to those skilled in the art and comprise non-aerosol pumps or "atomizers",
aerosol containers comprising a propellant and aerosol pumps using compressed air as
a propellant. The latter are described in the patents US 4,077,441 and US 4,850,517
(an integral part of the content of the description).
The compositions packaged in an aerosol suitable for the invention generally contain
conventional propellants such as for example the hydrofluorinated compounds
dichlorodifluoromethane, difluoroethane, dimethylether, isobutane, n-butane, propane,
trichlorofluoromethane. They are preferably present in amounts ranging from 15 to 50%
by weight with respect to the total weight of the composition.
The compositions packaged in an aerosol suitable for the invention generally contain
conventional propellants such as for example the hydrofluorinated compounds
dichlorodifluoromethane, difluoroethane, dimethylether, isobutane, n-butane, propane,
trichlorofluoromethane. They are preferably present in amounts ranging from 15 to 50%
by weight with respect to the total weight of the composition.
In the figures:
Figure 1 represents the absorption spectrum of the reference filter tested with, on
the x-axis, the wavelength in nanometers and, on the y-axis, the
absorbance (Abs);
Figure 2 represents a histogram of the fluorescence (%) as a function of the
compositions tested.
The concrete, but in no way limiting, examples illustrating the invention will now be given.
Furthermore, in the examples, all the percentages are given by weight, unless specified
otherwise, and the temperature is expressed in degrees Celsius unless specified
otherwise, and the pressure is atmospheric pressure, unless specified otherwise. In the
examples, the amounts of the ingredients of the compositions are given as a % by
weight with respect to the total weight of the composition.
Examples
Example 1: Study of skin protection under the effect of UVA by a composition according to
the invention
The purpose of this study was to express the protection performance with respect to
UVA stress. Baicalin is evaluated alone and according to the invention, in association
with a sunscreen composition 1 comprising a system filtering UVA comprising at least
one bis-resorcinyl triazine derivative.
Sunscreen composition 1
Phase Chemical name US INCI name Concentration
GLYCERYL MONO/DISTEARATE / POLYETHYLENE GLYCERYL STEARATE (and)
GLYCOL STEARATE MIXTURE (100 OE) PEG-100 STEARATE 1
POLY DIMETHYLSILOXANE (VISCOSITY: 350 CST) DIMETHICONE 0,5
POLYMETHYLENE WAX HAVING A MELTING
POINT OF APPROXIMATELY 64°C SYNTHETIC WAX 1
OCTANE-1 ,2 DIOL CAPRYLYL GLYCOL 0,4
ISOPROPYL N-LAUROYLSARCOSINATE ISOPROPYL LAUROYL SARCOSINATE 10
TRIAZINE DERIVATIVE (BEMT) = (2,4-BIS((4-(2-
ETHYL-HEXYL0XY)-2-HYDR0XY)-PHENYL)-6-(4- BIS-ETHYLHEXYLOXYPHENOL
METH0XYPHENYL)-(1 ,3,5)-TRIAZINE) METHOXYPHENYL TRIAZINE 1
2-ETHYL HEXYL 2-CYAN0-3.3-
DIPHENYLACRYLATE OCTOCRYLENE 5
4-TERTI OBUTYL-4 -METHOXYDIBENZOYLMETHANE
BUTYL METHOXYDIBENZOYLMETHANE 1,5
TRIETHANOLAMINE TRIETHANOLAMINE 0,2
PHENOXY-2 ETHANOL PHENOXYETHANOL 0,7
MICROBIOLOGICALLY CLEAN DEIONIZED WATER WATER 53,63
ETHYLENE DIAMINE TETRACETIC ACID,
DISODIUM SALT, 2 H20 DISODIUM EDTA 0,1
GLYCEROL GLYCERIN 6
PROPYLENE GLYCOL PROPYLENE GLYCOL 6
ACRYLIC ACID/STEARYL METHACRYLATE
COPOLYMER POLYMERIZED IN AN ETHYL ACRYLATES/C10-30 ALKYL ACRYLATE
ACETATE/CYCLOHEXANE MIXTURE CROSSPOLYMER 0,25
XANTHAN: POLYSACCHARIDES:
GLUCOSE/MANNOSE/GLUCURONIC ACID
(40/30/30) XANTHAN GUM 0,2
DEIONIZED WATER WATER 1
A 1 PLANT FATTY ACIDS (MAINLY STEARIC ACID) STEARIC ACID 1
CYCLOHEXA DIMETHYLSILOXANE (VISCOSITY: 8
A2 CST) CYCLOHEXASILOXANE 3
B-B'CAMPHOSULFONIC ACID [1-4 TEREPHTHALYLIDENE DICAMPHOR
B 1 DIVINYLBENZENE] IN AQUEOUS SOLUTION SULFONIC ACID 0,3
B 1 TRIETHANOLAMINE TRIETHANOLAMINE 0,05
NON-STABILIZED MONOPOTASSIUM MONOB2
CETYL PHOSPHATE POTASSIUM CETYL PHOSPHATE 1
C ISO-HEXADECANE ISOHEXADECANE 3
D TRIETHANOLAMINE TRIETHANOLAMINE 0,1 7
E DENATURED ABSOLUTE ETHYL ALCOHOL ALCOHOL DENAT. 3
Placebo composition 2
Phase Chemical name US INCI name Concentration
GLYCERYL MONO/DISTEARATE /
POLYETHYLENE GLYCOL STEARATE MIXTURE GLYCERYL STEARATE (and) PEG-100
(100 OE) STEARATE 1
POLY DIMETHYLSILOXANE (VISCOSITY: 350 CST) DIMETHICONE 0,5
POLYMETHYLENE WAX HAVING A MELTING
POINT OF APPROXIMATELY 64°C SYNTHETIC WAX 1
OCTANE-1 ,2 DIOL CAPRYLYL GLYCOL 0,4
ISOPROPYL N-LAUROYLSARCOSINATE ISOPROPYL LAUROYL SARCOSINATE 18,25
TRIETHANOLAMINE TRIETHANOLAMINE 0,2
PHENOXY-2 ETHANOL PHENOXYETHANOL 0,7
MICROBIOLOGICALLY CLEAN DEIONIZED WATER WATER 53, 18
ETHYLENE DIAMINE TETRACETIC ACID,
DISODIUM SALT, 2 H20 DISODIUM EDTA 0 ,1
GLYCEROL GLYCERIN 6
PROPYLENE GLYCOL PROPYLENE GLYCOL 6
ACRYLIC ACID/STEARYL METHACRYLATE
COPOLYMER POLYMERIZED IN AN ETHYL ACRYLATES/C10-30ALKYL
ACETATE/CYCLOHEXANEMIXTURE ACRYLATE CROSSPOLYMER 0,25
XANTHAN: POLYSACCHARIDES:
GLUCOSE/MANNOSE/GLUCURONIC ACID
(40/30/30) XANTHAN GUM 0,2
DEIONIZED WATER WATER 1
A 1 PLANT FATTYACIDS (MAINLY STEARIC ACID) STEARIC ACID 1
CYCLOHEXA DIMETHYLSILOXANE (VISCOSITY: 8
A2 CST) CYCLOHEXASILOXANE 3
B 1 TRIETHANOLAMINE TRIETHANOLAMINE 0,05
NON-STABILIZED MONOPOTASSIUM MONOB2
CETYL PHOSPHATE POTASSIUM CETYL PHOSPHATE 1
C ISO-HEXADECANE ISOHEXADECANE 3
D TRIETHANOLAMINE TRIETHANOLAMINE 0,1 7
E DENATURED ABSOLUTE ETHYL ALCOHOL ALCOHOL DENAT. 3
1.1. Method and protocols
Under our experimental conditions, exposure of NHF (Normal Human Fibroblasts) to UVA
induces the generation of activated oxygen species, measured using the DCFH-DA test.
The culture medium as follows:
- 500 ml of DMEM base medium with Glutamax 1,
- 50 ml of FCS,
- 5 ml of 250 mg/ml Fungizone Ampb B,
- 5 ml 200 mM L-glutamine
- 5 ml pennicilin-streptomycin
1.1.1. Conditions for evaluating protection against UVA radiation
The NHF cells are pretreated with the active substances for 24 hours before exposure to
UV. During the exposure of the fibroblasts to UVA, the reference formula ("Reference
filter" consisting of sunscreen composition 1) and the placebo formula (placebo
composition 2) are applied on a rough PMMA plate in the form of homogeneous and
regular deposition at a rate of 0.6mg/cm 2. The plate is then positioned over the culture
plate. The active substances (baicalin and/or system filtering UVA comprising at least one
bis-resorcinyl triazine derivative, referred to as the reference filter) under evaluation are
present during the solar simulation. The following combinations are evaluated:
- NHF + UVA + Placebo;
NHF + UVA + Placebo + baicalin;
NHF + UVA + Reference filter;
NHF + UVA + Reference filter + baicalin.
For the NHF cells treated with the active substance, a control plate is kept protected from
light.
The absorption spectrum of the reference filter (sunscreen composition 1) tested is shown
in figure 1. This filter comprises a bis-resorcinyl triazine derivative: TINOSORB S; and a
dibenzoylmethane derivative: Avobenzone; and a compound filtering UVA derived from
benzylidene camphor: Terephthalylidene Dicamphor Sulfonic Acid, associated with an
acrylate: octocrylene. This reference filter is already an optimal filter according to the
relevant prior art, per se, considered to be technically difficult to improve in respect to the
ability to protect the skin against UV.
1.1.2. Exposure conditions
The UVA are output with the Oriel solar simulator (Xenon lamp, 1000Watts), equipped
with a WG360/2mm filter. To obtain the entire UVA range, the UG1 1 visible section is not
used (however, it should be noted that the dichroic mirror of the solar simulator filters a
large portion of the visible range (85%)). The UVA emitted can be referred to as long UVA
as it is within the wavelengths of 340 to 400 nm.
1.1.3. DCFHDA test: Evaluation of UVA-induced oxidative stress
The protection against UVA stress is evaluated by means of a DCFH-DA test as a marker
of overall intracellular oxidative stress. This makes it possible to directly evaluate the
negative impact of UVA on a cellular level, and particularly on harmful oxidative stress for
the skin, hair and lips, particularly on skin tissue elasticity, promoting the appearance of
wrinkles giving rise to premature skin ageing.
The use of DCFH-DA as a marker of overall intracellular oxidative stress is based on the
physicochemical properties thereof. It consists of an apolar and non-ionic molecule
capable of diffusion via cell membranes. Once inside the cell, the DCFH-DA is hydrolyzed
by intracellular esterases to a non-fluorescent compound: DCFH or 2,7-dichlorofluorescin.
In the presence of activated oxygen species (H20 2; OH°), DCFH is rapidly oxidized to a
highly fluorescent compound: DCF or 2,7-dichlorofluorescein.
The fibroblasts, optionally in the presence of 10 mM Baicalin for 24 hours, are rinsed with
PBS+ and incubated in the presence of DCFH-DA [20mM] for 30 minutes at 37°C and
protected from light. After removing the probes and 2 rinses, the cells are again placed in
contact with the active substances (10 mM) in PBS+. PMMA plates whereon either
Vaseline (filter-free control) or the reference filtering formula have been applied are
deposited on top of the cells. Baicalin is introduced into the culture medium at a
concentration of 10 micromoles. They are then exposed to 20J/cm 2 of UVA (WG360 filter).
The fluorescence of DCF is evaluation immediately after exposure to UVA, by
spectrofluorimetry (Excitation 480nm; Emission 530nm).
1.2/ RESULTS
The evaluation of 10 mM Baicalin in the DCFH-DA test demonstrated the following results
(figure 2):
- sunscreen composition 1 partly protects fibroblasts against UVA-induced ROS
(Reactive Oxygen Species): 23-27% protection;
- associating sunscreen composition 1 with baicalin significantly improves the level of
biological protection provided to cells in the UVA range, with a 50% efficacy for the
"Baicalin + Reference filter" association.
In this way, these results demonstrate the surprisingly enhanced efficacy due to the
association of baicalin and a filtering system comprising a UVA filter comprising at least
one bis-resorcinyl triazine derivative, for protecting the skin and/or lips and/or hair
against solar radiation, particularly UV.
These results provide a means other than that consisting of using large amounts of UV
filters, particularly UVA filters, for combating premature ageing of the skin and/or lips
and/or hair effectively under conditions of use and in concentrations acceptable for
those skilled in the art.
Finally, these results particularly provide compositions, particularly cosmetic
compositions, for preventing and/or combating premature ageing of the skin and/or lips
due to UVA radiation and for protecting the skin and/or lips and/or hair against this form
of radiation and free radicals.
EXAMPLES OF FORMULATIONS
2 .1 FORMULATION A
MICROBIOLOGICALLY CLEAN DEIONIZED WATER AQUA 64,23
GLYCEROL GLYCERIN 6
PROPYLENE GLYCOL PROPYLENE GLYCOL 6
ISOPROPYL N-LAUROYLSARCOSINATE ISOPROPYL LAUROYL 5
SARCOSINATE
DENATURED ABSOLUTE ETHYL ALCOHOL ALCOHOL DENAT. 3
ISO-HEXADECANE ISOHEXADECANE 3
CYCLOHEXA DIMETHYLSILOXANE (VISCOSITY: 8 CST) CYCLOHEXASILOXANE 3
TRIAZINE DERIVATIVE (BEMT) = (2,4-BIS((4-(2-ETHYL- BIS-ETHYLHEXYLOXYPHENOL 1
HEXYLOXY)-2-HYDROXY)-PHENYL)-6-(4-METHOXYPHENYL)- METHOXYPHENYL TRIAZINE
( 1,3,5)-TRIAZINE)
NON-STABILIZED MONOPOTASSIUM MONO-CETYL POTASSIUM CETYL PHOSPHATE 1
PHOSPHATE
PLANT FATTY ACIDS (MAINLY STEARIC ACID) STEARIC ACID 1
GLYCERYL MONO/DISTEARATE / POLYETHYLENE GLYCOL GLYCERYL STEARATE ( ) PEG- 1
STEARATE MIXTURE (100 OE) 100 STEARATE
POLYMETHYLENE WAX HAVING A MELTING POINT OF SYNTHETIC WAX 1
APPROXIMATELY 64°C
DlISOPROPYL SEBACATE DIISOPROPYL SEBACATE 1
DEIONIZED WATER AQUA 1
PHENOXY-2 ETHANOL PHENOXYETHANOL 0,7
POLY DIMETHYLSILOXANE (VISCOSITY: 350 CST) DIMETHICONE 0,5
OCTANE-1.2 DIOL CAPRYLYL GLYCOL 0,4
ACRYLIC ACID/STEARYL METHACRYLATE COPOLYMER ACRYLATES/C10-30 ALKYL 0,25
POLYMERIZED IN AN ETHYL ACETATE/CYCLOHEXANE ACRYLATE CROSSPOLYMER
MIXTURE
BAICALIN (PURITY >95%) SCUTELLARIA BAICALENSIS ROOT SCUTELLARIA BAICALENSIS 0,2
EXTRACT EXTRACT
TRIETHANOLAMINE TRIETHANOLAMINE 0,2
XANTHAN: POLYSACCHARIDES: XANTHAN GUM 0,2
GLUCOSE/MANNOSE/GLUCURONIC ACID (40/30/30)
TRIETHANOLAMINE TRIETHANOLAMINE 0,17
ETHYLENE DIAMINE TETRACETIC ACID, DISODIUM SALT, 2 DISODIUM EDTA 0,1
H20
TRIETHANOLAMINE TRIETHANOLAMINE 0,05
2 .1 FORMULATION B
MICROBIOLOGICALLY CLEAN DEIONIZED WATER AQUA 62,73
GLYCEROL GLYCERIN 6
PROPYLENE GLYCOL PROPYLENE GLYCOL 6
ISOPROPYL N-LAUROYLSARCOSINATE ISOPROPYL LAUROYL SARCOSINATE 5
DENATURED ABSOLUTE ETHYL ALCOHOL ALCOHOL DENAT. 3
ISO-HEXADECANE ISOHEXADECANE 3
CYCLOHEXA DIMETHYLSILOXANE (VISCOSITY: 8 CST) CYCLOHEXASILOXANE 3
4-TERTIOBUTYL-4'-METHOXY-DIBENZOYLMETHANE BUTYL METHOXYDIBENZOYLMETHANE 1,5
TRIAZINE DERIVATIVE (BEMT) = (2,4-BIS((4-(2-ETHYL- BIS-ETHYLHEXYLOXYPHENOL 1
HEXYLOXY)-2-HYDROXY)-PHENYL)-6-(4- METHOXYPHENYL TRIAZINE
METHOXYPHENYL)-(1 ,3,5)-TRIAZINE)
NON-STABILIZED MONOPOTASSIUM MONO-CETYL POTASSIUM CETYL PHOSPHATE 1
PHOSPHATE
PLANT FATTY ACIDS (MAINLY STEARIC ACID) STEARIC ACID 1
GLYCERYL MONO/DISTEARATE / POLYETHYLENE GLYCERYL STEARATE ( ) PEG-100 1
GLYCOL STEARATE MIXTURE (100 OE) STEARATE
POLYMETHYLENE WAX HAVING A MELTING POINT OF SYNTHETIC WAX 1
APPROXIMATELY 64°C
DlISOPROPYL SEBACATE DlISOPROPYL SEBACATE 1
DEIONIZED WATER AQUA 1
PHENOXY-2 ETHANOL PHENOXYETHANOL 0,7
POLY DIMETHYLSILOXANE (VISCOSITY: 350 CST) DIMETHICONE 0,5
OCTANE-1.2 DIOL CAPRYLYL GLYCOL 0,4
ACRYLIC ACID/STEARYL METHACRYLATE ACRYLATES/C10-30 ALKYL ACRYLATE 0,25
COPOLYMER POLYMERIZED IN AN ETHYL CROSSPOLYMER
ACETATE/CYCLOHEXANE MIXTURE
BAICALIN (PURITY >95%) SCUTELLARIA BAICALENSIS SCUTELLARIA BAICALENSIS EXTRACT 0,2
ROOT EXTRACT
TRIETHANOLAMINE TRIETHANOLAMINE 0,2
XANTHAN: POLYSACCHARIDES: XANTHAN GUM 0,2
GLUCOSE/MANNOSE/GLUCURONIC ACID (40/30/30)
TRIETHANOLAMINE TRIETHANOLAMINE 0,17
ETHYLENE DIAMINE TETRACETIC ACID, DISODIUM DISODIUM EDTA 0,1
SALT, 2 H20
TRIETHANOLAMINE TRIETHANOLAMINE 0,05
2 .1 FORMULATION C
MICROBIOLOGICALLY CLEAN DEIONIZED WATER AQUA 59,23
GLYCEROL GLYCERIN 6
PROPYLENE GLYCOL PROPYLENE GLYCOL 6
ISOPROPYL N-LAUROYLSARCOSINATE ISOPROPYL LAUROYL 5
SARCOSINATE
2-ETHYL HEXYL 2-CYANO-3,3-DIPHENYLACRYLATE OCTOCRYLENE 5
DENATURED ABSOLUTE ETHYL ALCOHOL ALCOHOL DENAT. 3
ISO-HEXADECANE ISOHEXADECANE 3
CYCLOHEXA DIMETHYLSILOXANE (VISCOSITY: 8 CST) CYCLOHEXASILOXANE 3
TRIAZINE DERIVATIVE (BEMT) = (2,4-BIS((4-(2-ETHYL- BIS-ETHYLHEXYLOXYPHENOL 1
HEXYLOXY)-2-HYDROXY)-PHENYL)-6-(4-METHOXYPHENYL)- METHOXYPHENYL TRIAZINE
( 1,3,5)-TRIAZINE)
NON-STABILIZED MONOPOTASSIUM MONO-CETYL POTASSIUM CETYL PHOSPHATE 1
PHOSPHATE
PLANT FATTY ACIDS (MAINLY STEARIC ACID) STEARIC ACID 1
GLYCERYL MONO/DISTEARATE / POLYETHYLENE GLYCOL GLYCERYL STEARATE ( ) PEG- 1
STEARATE MIXTURE (100 OE) 100 STEARATE
POLYMETHYLENE WAX HAVING A MELTING POINT OF SYNTHETIC WAX 1
APPROXIMATELY 64°C
DIISOPROPYL SEBACATE DIISOPROPYL SEBACATE 1
DEIONIZED WATER AQUA 1
PHENOXY-2 ETHANOL PHENOXYETHANOL 0,7
POLY DIMETHYLSILOXANE (VISCOSITY: 350 CST) DIMETHICONE 0,5
OCTANE-1.2 DIOL CAPRYLYL GLYCOL 0,4
ACRYLIC ACID/STEARYL METHACRYLATE COPOLYMER ACRYLATES/C10-30 ALKYL 0,25
POLYMERIZED IN AN ETHYL ACETATE/CYCLOHEXANE ACRYLATE CROSSPOLYMER
MIXTURE
BAICALIN (PURITY >95%) SCUTELLARIA BAICALENSIS ROOT SCUTELLARIA BAICALENSIS 0,2
EXTRACT EXTRACT
TRIETHANOLAMINE TRIETHANOLAMINE 0,2
XANTHAN: POLYSACCHARIDES: XANTHAN GUM 0,2
GLUCOSE/MANNOSE/GLUCURONIC ACID (40/30/30)
TRIETHANOLAMINE TRIETHANOLAMINE 0,17
ETHYLENE DIAMINE TETRACETIC ACID, DISODIUM SALT, 2 DISODIUM EDTA 0,1
H20
TRIETHANOLAMINE TRIETHANOLAMINE 0,05
2.4 FORMULATION D
MICROBIOLOGICALLY CLEAN DEIONIZED WATER AQUA 63,93
GLYCEROL GLYCERIN 6
PROPYLENE GLYCOL PROPYLENE GLYCOL 6
ISOPROPYL N-LAUROYLSARCOSINATE ISOPROPYL LAUROYL 5
SARCOSINATE
DENATURED ABSOLUTE ETHYL ALCOHOL ALCOHOL DENAT. 3
ISO-HEXADECANE ISOHEXADECANE 3
CYCLOHEXA DIMETHYLSILOXANE (VISCOSITY: 8 CST) CYCLOHEXASILOXANE 3
TRIAZINE DERIVATIVE (BEMT) = (2,4-BIS((4-(2-ETHYL- BIS-ETHYLHEXYLOXYPHENOL 1
HEXYLOXY)-2-HYDROXY)-PHENYL)-6-(4-METHOXYPHENYL)- METHOXYPHENYL TRIAZINE
( 1,3,5)-TRIAZINE)
NON-STABILIZED MONOPOTASSIUM MONO-CETYL POTASSIUM CETYL PHOSPHATE 1
PHOSPHATE
PLANT FATTY ACIDS (MAINLY STEARIC ACID) STEARIC ACID 1
GLYCERYL MONO/DISTEARATE / POLYETHYLENE GLYCOL GLYCERYL STEARATE ( ) PEG- 1
STEARATE MIXTURE (100 OE) 100 STEARATE
POLYMETHYLENE WAX HAVING A MELTING POINT OF SYNTHETIC WAX 1
APPROXIMATELY 64°C
DIISOPROPYL SEBACATE DIISOPROPYL SEBACATE 1
DEIONIZED WATER AQUA 1
PHENOXY-2 ETHANOL PHENOXYETHANOL 0,7
POLY DIMETHYLSILOXANE (VISCOSITY: 350 CST) DIMETHICONE 0,5
OCTANE-1.2 DIOL CAPRYLYL GLYCOL 0,4
B-B'CAMPHOSULFONIC ACID [1-4 DIVINYLBENZENE] IN TEREPHTHALYLIDENE DICAMPHOR 0,3
AQUEOUS SOLUTION SULFONIC ACID
ACRYLIC ACID/STEARYL METHACRYLATE COPOLYMER ACRYLATES/C10-30 ALKYL 0,25
POLYMERIZED IN AN ETHYL ACETATE/CYCLOHEXANE ACRYLATE CROSSPOLYMER
MIXTURE
BAICALIN (PURITY >95%) SCUTELLARIA BAICALENSIS ROOT SCUTELLARIA BAICALENSIS 0,2
EXTRACT EXTRACT
TRIETHANOLAMINE TRIETHANOLAMINE 0,2
XANTHAN: POLYSACCHARIDES: XANTHAN GUM 0,2
GLUCOSE/MANNOSE/GLUCURONIC ACID (40/30/30)
TRIETHANOLAMINE TRIETHANOLAMINE 0,17
ETHYLENE DIAMINE TETRACETIC ACID, DISODIUM SALT, 2 DISODIUM EDTA 0,1
H20
TRIETHANOLAMINE TRIETHANOLAMINE 0,05
2.5 FORMULATION E
MICROBIOLOGICALLY CLEAN DEIONIZED WATER AQUA 62,43
GLYCEROL GLYCERIN 6
PROPYLENE GLYCOL PROPYLENE GLYCOL 6
ISOPROPYL N-LAUROYLSARCOSINATE ISOPROPYL LAUROYL SARCOSINATE 5
DENATURED ABSOLUTE ETHYL ALCOHOL ALCOHOL DENAT. 3
ISO-HEXADECANE ISOHEXADECANE 3
CYCLOHEXA DIMETHYLSILOXANE (VISCOSITY: 8 CYCLOHEXASILOXANE 3
CST)
4-TERTIOBUTYL-4 -METHOXY- BUTYL METHOXYDIBENZOYLMETHANE 1,5
DIBENZOYLMETHANE
TRIAZINE DERIVATIVE (BEMT) = (2,4-BIS((4-(2- BIS-ETHYLHEXYLOXYPHENOL 1
ETHYL-HEXYLOXY)-2-HYDROXY)-PHENYL)-6-(4- METHOXYPHENYL TRIAZINE
METHOXYPHENYL)-(1 ,3,5)-TRIAZINE)
NON-STABILIZED MONOPOTASSIUM MONO- POTASSIUM CETYL PHOSPHATE 1
CETYL PHOSPHATE
PLANT FATTY ACIDS (MAINLY STEARIC ACID) STEARIC ACID 1
GLYCERYL MONO/DISTEARATE / POLYETHYLENE GLYCERYL STEARATE (AND) PEG-100 1
GLYCOL STEARATE MIXTURE (100 OE) STEARATE
POLYMETHYLENE WAX HAVING A MELTING SYNTHETIC WAX 1
POINT OF APPROXIMATELY 64°C
DIISOPROPYL SEBACATE DIISOPROPYL SEBACATE 1
DEIONIZED WATER AQUA 1
PHENOXY-2 ETHANOL PHENOXYETHANOL 0,7
POLY DIMETHYLSILOXANE (VISCOSITY: 350 CST) DIMETHICONE 0,5
OCTANE-1 .2 DIOL CAPRYLYL GLYCOL 0,4
B-B'CAMPHOSULFONIC ACID [1-4 TEREPHTHALYLIDENE DICAMPHOR 0,3
DIVINYLBENZENE] IN AQUEOUS SOLUTION SULFONIC ACID
ACRYLIC ACID/STEARYL METHACRYLATE ACRYLATES/C10-30 ALKYL ACRYLATE 0,25
COPOLYMER POLYMERIZED IN AN ETHYL CROSSPOLYMER
ACETATE/CYCLOHEXANE MIXTURE
BAICALIN (PURITY >95%) SCUTELLARIA SCUTELLARIA BAICALENSIS EXTRACT 0,2
BAICALENSIS ROOT EXTRACT
TRIETHANOLAMINE TRIETHANOLAMINE 0,2
XANTHAN: POLYSACCHARIDES: XANTHAN GUM 0,2
GLUCOSE/MANNOSE/GLUCURONIC ACID
(40/30/30)
TRIETHANOLAMINE TRIETHANOLAMINE 0,1 7
ETHYLENE DIAMINE TETRACETIC ACID, DISODIUM EDTA 0,1
DISODIUM SALT, 2 H20
TRIETHANOLAMINE TRIETHANOLAMINE 0,05

CLAIMS
1. Photoprotective composition for topical use comprising baicalin or an extract
containing same, and at least one system filtering UVA radiation comprising at least one
bis-resorcinyl triazine derivative.
2. Composition according to claim 1, characterized in that said bis-resorcinyl triazine
derivative is selected from the group consisting of 2,4-bis {[4-(2-ethyl-hexyloxy)-2-
hydroxy]-phenyl}-6-(4-methoxy-phenyl)-1 ,3,5-triazine; 2,4-bis {[4-(tris (trimethyisiloxy)
silylpropyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1 ,3,5-triazine; 2,4-bis{[4-
( 1' ,1' ,1',3',5',5',5'-heptamethyltrisiloxy-2"-methylpropyloxy)-2-hydroxy]-phenyl}-6-(4-
methoxyphenyl)-1 ,3,5-triazine; and bis-ethylhexyloxyphenol methoxyphenyl triazine, and
preferably is bis-ethylhexyloxyphenol methoxyphenyl triazine.
3. Composition according to claim 1 or 2, characterized in that it further comprises at
least one other UVA filter selected from a dibenzoylmethane derivative, and preferably
Avobenzone (1-(4-Methoxyphenyl)-3-(4-fe/t-butylphenyl)propane-1 ,3-dione), and a
compound filtering UVA derived from benzylidene camphor, and preferably
Terephthalylidene Dicamphor Sulfonic Acid.
4. Composition according to any of claims 1 to 3, characterized in that it further
comprises at least one UVB filter and preferably a b ,b '-diphenylacrylate, and more
preferably octocrylene.
5. Composition according to claim 1, characterized in that said system filtering UVA
radiation comprises at least Bis-Ethylhexylphenol Methoxyphenyltriazine, Avobenzone,
and Terephthalylidene Dicamphor Sulfonic Acid, and characterized in that said
composition further comprises octocrylene.
6. Composition according to any of claims 1 to 5, characterized in that it further
comprises other compounds filtering UVA and/or UVB.
7. Composition according to any of claims 1 to 6, characterized in that it further
comprises cosmetically acceptable excipients.
8. Baicalin, or extract containing same, in association with at least one system filtering
UVA radiation comprising at least one bis-resorcinyl triazine for protecting the skin
and/or lips and/or hair against solar radiation.
9. Multi-constituent agent for the photoprotection of human keratin material (skin, lips,
hair, eyelashes, eyebrows, nails) comprising a composition A and a composition B
packaged separately;
said composition A comprising, in a cosmetically acceptable medium, at least baicalin or
an extract containing same as defined in the above claims;
said composition B comprising, in a cosmetically acceptable medium, at least one
system filtering UVA radiation comprising at least one bis-resorcinyl triazine derivative
as defined in the above claims;
said composition A and said composition B being applied either simultaneously or
sequentially on the surface of the keratin material.
10. Multi-constituent agent according to claim 9, where the application of composition A
and the application of composition B are sequential and where composition A
comprising baicalin is applied first.
11. Multi-constituent agent according to claim 10, where the time interval between the
applications of A and B varies from 1 hour to 48 hours and more preferentially from 1
hour to 24 hours; filtering composition B being suitable for application immediately prior
to exposure to UV particularly to solar radiation.
12. Composition, as defined in any of claims 1 to 7 or multi-constituent agent as defined
in any of claims 9 to 11, for combating or preventing photo-induced premature ageing of
the skin and/or lips and/or hair by topical application on the skin and/or lips and/or hair.
13. Composition, as defined in any of claims 1 to 7 or multi-constituent agent as defined
in any of claims 9 to 11, for protecting the skin and/or lips and/or hair against solar
radiation by topical application on the skin and/or lips and/or hair.