Polymorphs Of Ibrutinib

Dr. Reddy’s Laboratories Limited
Withdrawn App No 201747034226 Chemical

Patent information

IP India · live record
Application number
201747034226
Filing date
27 September 2017
Status
Withdrawn
Publication number
41/2017
Publication type
INA
Invention field
Chemical

Abstract

The present invention provides crystalline forms of Ibrutinib and processes for their preparation.

Applicants

1
India
Dr. Reddy’s Laboratories Limited 8-2-337 Road No. 3 Banjara Hills, Telangana, Hyderabad 500 034.

Inventors

6
India
PEDDY VishweshwarPlot No. 341, Vasavi colony, Green Hills Road No: 1, Saroornagar post, Hyderabad- 500035
India
VELAGA Dharma Jagannadha RaoD. No: 9-4, Pallapu street, Munagapaka village, Vishakapatnam (Dist), Andhra Pradesh - 531033, India.
India
KANNIAH Sundara Lakshmi101, Periya Kalani Kattu Street, Velapadi, Vellore 632 001, Tamilnadu, India
India
CHENNURU RamanaiahVelagala Ponnuru Village Post, Sulluru Pet- 524121, Nellore, Andhra Pradesh, India.
India
RAMAKRISHNAN SrividyaH. No. 1005/2A, SMR Vinay city, Miyapur, Hyderabad, Andhra Pradesh, India 500 049
India
RANGINENI SrinivasMachinenipalli, Yenmenvetla, Kollapur, Mahabubnagar, Telangana – 509102, India.

Claims

6
1 Crystalline form D1 of Ibrutinib characterized by an X-ray Powder Diffraction Pattern (PXRD) having peaks at about 10.11, 11.45, 18.47 and 20.89 ± 0.20 degrees 2Ɵ.
2 Crystalline form D1 of Ibrutinib of claim 1, further characterized by PXRD pattern having additional peaks located at about 5.04, 10.79, 23.10 and 26.60 ± 0.20 degrees 2Ɵ.
3 Crystalline form D1 of Ibrutinib characterized by an X-ray Powder Diffraction Pattern (PXRD) as shown figure 18.
4 A process for preparing crystalline Form D1 of Ibrutinib, comprising the steps of: a. obtaining a solution of ibrutinib in an alcohol; b. combining the solution of step a) with an anti-solvent; and c. isolating crystalline form D1 of Ibrutinib.
5 The process of claim 4 wherein, the alcohol is selected from methanol, ethanol, propanol, isopropanol, butanol, iso-butanol and pentanol.
6 The process of claim 4 wherein, the anti-solvent is water.

Specification

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CLAIMS: We Claim: 1. Crystalline form D1 of Ibrutinib characterized by an X-ray Powder Diffraction Pattern (PXRD) having peaks at about 10.11, 11.45, 18.47 and 20.89 ± 0.20 degrees 2Ɵ. 2. Crystalline form D1 of Ibrutinib of claim 1, further characterized by PXRD pattern having additional peaks located at about 5.04, 10.79, 23.10 and 26.60 ± 0.20 degrees 2Ɵ. 3. Crystalline form D1 of Ibrutinib characterized by an X-ray Powder Diffraction Pattern (PXRD) as shown figure 18. 4. A process for preparing crystalline Form D1 of Ibrutinib, comprising the steps of: a. obtaining a solution of ibrutinib in an alcohol; b. combining the solution of step a) with an anti-solvent; and c. isolating crystalline form D1 of Ibrutinib. 5. The process of claim 4 wherein, the alcohol is selected from methanol, ethanol, propanol, isopropanol, butanol, iso-butanol and pentanol. 6. The process of claim 4 wherein, the anti-solvent is water.

Documents

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Application documents
1 201747034226-STATEMENT OF UNDERTAKING (FORM 3) [27-09-2017(online)].pdf 27 Sep 2017
2 201747034226-DRAWINGS [27-09-2017(online)].pdf 27 Sep 2017
3 201747034226-DECLARATION OF INVENTORSHIP (FORM 5) [27-09-2017(online)].pdf 27 Sep 2017
4 201747034226-COMPLETE SPECIFICATION [27-09-2017(online)].pdf 27 Sep 2017
5 201747034226.pdf 28 Sep 2017