Abstract: ABSTRACT Title: PORTABLE SEIZURE PREDICTION AND COMMUNICATION SYSTEM The present invention relates to methods and devices for predicting and intimating the seizure (a symptom of neurological disease) attack to user and caretakers. The present invention includes analyzing the EEG signals of the user/patient through the signal processor and warns the user about seizure attack by alarm and intimates the current location of the user to the group of people (caretakers) for assistance to the user from nearest location people. The intimation is by sending SMS to the group of people simultaneously from the user mobile by POO (Push to talk Over Cellular) facility for the users of the same network. For users of the different networks the transmission is through different wired (Internet Protocol etc.) and wireless networks (short range, broadband, cellular etc.)
INTRODUCTION
Approximately one in every 100 persons will experience a neurological seizure (A sudden occurrence of a disease) at some time in their life. Epileptic seizures are the result of transient and unexpected electrical disturbance of the brain. On analyzing the electrical activity of the brain the present invention predicts the seizure attack and communicates to user and his/her well wisher/the medical practitioner. The present invention warns the user of his neurological disease and in parallel this system communicates to the caretakers of his current location (GPS information). The alarm signal/lED is used for intimating the user and cell phone is used to send the SMS to the caretakers of his location. Here this system uses Electroencephalogram (EEG) to find the neurological disease of the user/patient. The signal processor of the seizure prediction system processes the EEG signals. The abnormality in the brain activity enables the alarm for user's attention. At the same moment the Bluetooth GPS receiver sends the current location of the user to user's mobile and the software of the mobile sends this message to the list of his caretakers/medical practitioner. The user's location is forwarded to care takers group by the PTT (Push To Talk) or through mobile software. If any changes in the user's neurological status this system suddenly activates the alarm and it sends the message to his friends/well-wishers through his mobile. This present invention has the Global positioning system receiver. So using this GPS, the system detects the user's current place, direction and time and sends this information to the caretakers. The neurological disorder patients can use this system at the time of traveling, sleeping and working time also to analyze his neurological status every time and intimating his status to his doctor or well-wishers.
BACKGROUND OF THE INVENTION
More than 40 million people have Neurological disease worldwide. Approximately one in every 100 persons will experience a neurological seizure (A sudden
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occurrence of a disease) at some time in their life. One of tlie most disabling aspects of epilepsy is the seemingly unpredictable nature of seizures. Until recently the interictal-ictal transition was believed to be an abrupt phenomenon, occurring without warning. It's very useful to predict the seizure for many reasons like,
1. Possible to reduce the side affects of antiepileptic drugs by just electrical stimulation or drug infusion activated only during the pre-seizure period instead of for the whole course duration for users who are controlled by antiepileptic drugs.
2. Patients who cannot be controlled by medications or who are not the candidates suitable for epilepsy surgery might be helped by new therapies.
This invention improves the quality of life for epilepsy patients. The neurological patients should be careful while traveling, doing electrical work, and working with machinery and while driving.
The patent US2006/020038 focused mainly on the prediction of the seizure. The communication to the caretakers is not covered in that patent. This invention concentrates on communicating the user's location to the caretakers in his pre-seizure state. At the time of traveling also, this system is easier to carry and useful to warn the user as well as gets the attention of the surrounding people. So the user can use the antiepileptic drugs to prevent the attack on reception of the warning signal.
Seizure Prediction Methods
1. Dynamical similarity index
2. Effective correlation dimension
3. Accumulated energy
The normal Electroencephalogram is used by these methods to analyze the Electrode signals. But those systems are all used in hospitals only. Those
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systems are not easy to carry and the doctor needs the help of the EEG graph technician for the end results. But this invention Is the only one to focus on automatic intimation to the caretakers of that patient and warns the user of his neurological disorder.
SUMMARY OF THE INVENTION
The present invention relates to the design of system and methods for analysis, prediction and intimation of the neurological disease to the user as well as to the caretakers. That is whenever the neurological patient is in pre-ictal state, this invention detects and sends his current location, time, direction to the caretakers group of user by using POC of the user's mobile or using software of user's mobile for forwarding the SMS (GPS location) from user's mobile.
The prediction of the neurological seizure is by the analysis of EEG graphs. After getting EEG signal, the palm size device having signal analyzer take care of the prediction and intimation of the seizure. If the signal analyzer predicts or detects abnormality means it sends the signal to alarm and GPS receiver to send the information to care takers mobile by activating the user mobile's POC (Push to talk Over Cellular) or through the mobile's software.
BRIEF DECRIPTION OF ACCOMPANYING DRAWINGS
FIG 1 & 2 represents the complete block diagram of this invention with some
different design aspects.
FIG 3 shows a diagrammatic representation of electrodes placed in a cap.
FIG 4 shows the electrodes used in the measurement of EEG.
FIG 5 represents the signal analyzer, how it can connect with the electrode cap.
DETAIlED DESCRIPTION OF THE INVENTION WITH REFERENCE TO ACCOMPANYING DRAWINGS
Fig 1 represents the complete block view of the invention. The main components of this invention are electrodes, seizure prediction system, and users mobile and care takers mobile. The seizure prediction system constitutes signal processor,
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decision maker, Bluetooth street location navigator (GPS receiver), and warning alarm (14). Signal flow also represented in that diagram, that is the signal analyzer (13) analyzes the electrodes signal from the time the system gets switched on. In analysis if it predicts the seizure it warns the user by alarm and activates the GPS receiver (15) for transmission of user's current location to the user's mobile (16). From the user mobile this location information is forwarded to caretakers mobile (17) by using software for SMS forwarding and this transmission is possible simultaneously to the group of caretakers by the POC facility of the mobile. This invention is useful even with a normal mobile with bluetooth interface. In normal mobile the user has to add the people to the group and the software for SMS forward is used to send the SMS to those group of people in sequential order.
Fig 2 also represents the block view with some little bit changes in the design appears. That is GPS located inside the user mobile phone. So in this design the user needs to carry the GPS enabled mobile phone at the time of using this Seizure prediction System to predict the neurological disorder. The POC of the mobile is used to transmit the SMS to caretakers group simultaneously. If not it sends the SMS of his location to the group of caretakers in sequential order.
FIG 3 shows a diagrammatic representation of electrodes (11 & 12) placed in a cap. In this invention the total setup is encapsulated with in a device except the electrodes. Depends upon the signal analyzing methods two or more electrodes can be used to capture the electrical activity of the brain. This Electrode cap is easily wearable and lightweight too. As per the user requirement the manufacturer can design this cap as much as suitable and stylish.
FIG 4 shows the electrodes used in the measurement of EEG. So many models are there in electrodes. But the electrode with gel is best suited for this invention. The main part of the system is the electrodes. In this design the electrodes are encapsulated inside the cap, and sticked to the user's scalp. The electrodes in the cap are placed on the scalp of the user for prediction of the seizure. These
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electrodes one end is placed on the scalp and the other end are connected to the signal analyzer of the seizure prediction system. The normal EEG electrodes (1' & 12) are used here to get the Electroencephalogram signal from user Electroencephalogram (EEG) as a representative signal containing information of the electrical activity generated by the cerebral cortex nerve cells has been the most utilized signal to clinically assess brain activities, and the detection of epileptiform discharges in the EEG is an important component in the diagnosis of epilepsy. These electrodes connected to the signal analyzer of the seizure prediction system.
FIG 5 represents the signal analyzer (13), how it can connect with the electrode cap. Normally two electrodes are used to find the EEG, in this figure that two outputs of the electrodes are connected with the palm size seizure prediction system having signal analyzer. Here the signal analyzer, which is the part of seizure prediction system, takes the signals from two electrodes (11 & 12), into a signal processor. It processes the signals of those 2 electrodes for the prediction of seizure. That decision maker of the signal analyzer has the capability to send the signal to warning alarm (14) and Bluetooth GPS receiver (15). There is some signal analyzing methods already there to predict the seizure from electrode signals. This invention uses those well-known methods to predict the neurological seizure of the user.
The Seizure prediction system has bluetooth GPS receiver. It mentioned in figure 1. It Activates the user's mobile (16) through bluetooth (15) at the time of seizure prediction. The user's mobile should be with bluetooth interface and it should be in ON state to get the GPS information from the system. The user's mobile contain a list of caretakers. If the user mobile got signal from seizure detection system through bluetooth means it sends that GPS information with some stored message like "I'm getting neurological seizure at 'GPS info'. The caretakers get this information of his current location and the time of seizure attacked in his/her mobile (17). POO of user's mobile forwards this GPS information simultaneously to all caretakers in half duplex communication.
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like a cell phone, a GPS receiver relies on radio waves. But instead of using towers on the ground, it communicates with satellites that orbit the Earth. There are currently 27 GPS satellites in orbit, 24 are in active use and 3 act as a backup in case another satellite fails. Normally it weighs within 80g. In order to determine your location, a GPS receiver has to determine:
• The locations of at least three satellites above the user
• Where the user are in relation to those satellites
The receiver then uses trilateration to determine the user's exact location. Basically, it draws a sphere around each of three satellites it can locate. These three spheres intersect In two points - one is in space, and one is on the ground. The point on the ground at which the three spheres intersect is your location.
It takes the input power of 5V DC and has a operational power of 3.3V DC. Bluetooth is a wireless protocol utilizing short-range communications technology facilitating data transmissions over short distances from fixed and/or mobile devices, creating wireless personal area networks (PANs).
Bluetooth(Figure1, 15) provides a way to connect and exchange information between devices such as mobile phones, telephones, laptops, personal computers, printers, video game consoles, digital cameras, and GPS Rceivers over a secure, globally unlicensed Industrial, Scientific, and Medical (ISM) 2.4 GHz short-range radio frequency bandwidth.
Bluetooth is a standard and communications protocol primarily designed for low power consumption, with a short range power-class-dependent: 1 meter, 10 meters, 100 meters) based on low-cost transceiver, microchips in each device. Bluetooth enables these devices to communicate with each other when they are in range. The devices use a radio communications system, so they do not have to be in line of sight of each other, and can even be in other rooms, as long as the received transmission is powerful enough.
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Here in this invention the bluetooth GPS Receiver (15) is the main component of the Seizure detection system. Whenever the neurological or epileptic seizure detected by the Signal Analyzer, it will send the GPS information as a SMS to user mobile via bluetooth, using NMEA-0183 protocol. The data Is being transmitted using the bluetooth serial port profile. The user mobile gets this GPS Information; and the mobile software (SMS Interceptor) In the user's mobile forwards this SMS to the predefined number/list of caretakers stored In the mobile. The SMS forwarder instantly catches all Incoming and outgoing SMS on the target device (where the software is Installed) and forwards them silently to the pre-defined numbers using POC (or PTT) for the first block diagram. For the second block diagram the forwarding software Is not needed, as GPS receiver Is encapsulated within the mobile. Only POC of the phone is used to send the message to caretakers.
This software of mobile for forwarding of SMS automatically sends an SMS (Short Message Service) to the predefined number/well-wisher list, stored by the user already. This software has to be activated by the user at the time of wearing the electrodes cap. He can deactivate that software when he does not need it. This Software silently starts up on phone boot or restart, If It is in active State. This software needs not to be installed on the caretakers mobile.
The other possibility is to activate and deactivate the SMS Interceptor software on the user's mobile remotely by the use of SMS also. The Bluetooth GPS receiver (15) sends the SMS to activate this software on the user's mobile when the receiver needs to transmit the GPS location information to user's mobile. Then it sends the GPS location Information to the users mobile. As the software to fonward the SMS is already activated on the mobile it forwards the GPS location information to the caretakers simultaneously by POC.
TERMINlOlOGY
Seizure
The brain is tine center that controls and regulates all voluntary and involuntary responses in the body. It consists of nerve cells that normally communicate with each other through electrical activity. A seizure occurs when part(s) of the brain receives a burst of abnormal electrical signals that temporarily interrupts normal electrical brain function. It's a symptom of epilepsy.
EEG (Electroencephalogram)
EEGs are non-invasive and do not involve any X-rays, radiation, or injections. EEGs have been used for many years and are considered very safe. The electrodes record activity without producing any sensation. Slight redness may occur in the locations where the electrodes were placed, but this will wear off after a few hours. EEG, or electroencephalogram, is a tool we use to image the brain while it is performing a cognitive task. This allows us to detect the location and magnitude of brain activity involved in the various types of cognitive functions. EEG allows us to view and record the changes in your brain activity during the time you are performing the task.
Electrode
An electrode is an electrical conductor used to make contact with a nonmetallic part of a circuit. An electrode in an electrochemical cell is referred to as either an anode or a cathode. The anode is now defined as the electrode at which electrons leave the cell and oxidation occurs, and the cathode as the electrode at which electrons enter the cell and reduction occurs. Each electrode may become either the anode or the cathode depending on the voltage applied to the cell. A bipolar electrode is an electrode that functions as the anode of one cell and the cathode of another cell. In medical field electrodes are used in ECG
GPS Receiver
It is an electronic device, which receives and decodes the GPS satellite broadcasts and displays the current location, direction, and speed of the particulars. Here GPS means Global Positioning System. It is the only fully functional Global Navigation Satellite System (GNSS). The GPS uses a constellation of 24 Medium Earth Orbit satellites that transmit precise microwave signals that enable GPS receivers to determine their location, speed, direction, and time.
Bluetooth
Bluetooth is a wireless protocol utilizing short-range communications technology facilitating data transmissions over short distances from fixed and/or mobile devices.
Personal Area Network (PAN)
A personal area network (PAN) is the interconnection of information technology devices within the range of an individual person, typically within a range of 10 meters. For typically, this kind of personal area network could also be interconnected without wires to the Internet or other networks. The IEEE 802.15 family of "Home Wireless" standards embodies PAN standards.
ISM (Industrial Scientific and Medical) band
This frequency band refers to the frequency range from 2.4 to 2.4835 GHz which is unlicensed and used for many communications applications, including Bluetooth and Wi-Fi.
Wavelet
A wavelet is a kind of mathematical function used to divide a given function or continuous-time signal into different frequency components and study each component with a resolution that matches its scale.
Wavelet Transform
Wavelet transform is the representation of a function by wavelets
DWT (Discrete Wavelet Transform)
The wavelets in this transform are discretely sampled.
NMEA-0183 (National Marine Electronics Association)
This protocol used for accessing the GPS receiver from mobile phone through the Bluetooth.
Pre-seizure Period
This phase may be defined as a functional state in which epileptic brain will evolve into a seizure unless some kind of intervention takes place.
POC (Push to talk Over Cellular)
Push-to-talk (PTT), also known as Press-to-Transmit, is a method of conversing on half-duplex communication lines, including two-way radio, using a momentary button to switch from voice reception mode to transmit mode. PTT PoC or Push to Talk over Cellular is a feature similar to walkie-talkie that is provided over a cellular phone network. A typical Push to Talk connection connects almost instantly. One significant advantage of PoC is allowing a single person to reach an active talk group at a button press, thus users no longer need to make several calls to coordinate with a group. Push-to-talk calls are half duplex communication while one person speaks, the other(s) listen(s).
Two-way radio
A two-way radio is a radio that can both transmit and receive. An example of a two-way radio that both transmits and receives at the same time (or full-duplex) is a mobile phone or cellular telephone, which uses two different radio frequencies to carry the two directions of the conversation simultaneously.
Half Duplex Communication
A half-duplex system provides for communication in both directions, but only one direction at a time (not simultaneously). Typically, once a party begins receiving a signal, it must wait for the transmitter to stop transmitting, before replying.
Full Duplex Communication
A full-duplex, or sometimes double-duplex system allows communication in both directions, and unlike half-duplex, allows this to happen simultaneously. Land-line telephone networks are full-duplex since they allow both callers to speak and be heard at the same time. Examples: Telephone, Mobile Phone, etc.
INDUSTRIAL APPLICABILITY
1. Medical Instrumentation
2. Current location navigator
CLAIMS
1 The System Claims
a. In this invention, the neurological seizure predictor is easily transportable
device anywhere, anytime to monitor the brain activity.
b. In this invention, at the time of patient getting the seizure attack the GPS
information like Name of that particular location, Direction, Time of that
particular place where patient/user is there is transmitted to the user
mobile via bluetooth from Bluetooth GPS receiver.
c. In this invention, the GPS information gets transmitted to the user (The
person/patient is using this invention system) at the same time it activates
the Application software, which is installed in user mobile for automatic
transmission of SMS to caretakers list using POC for the caretakers of the
same network.
d. In this invention, through POC the GPS information and some stored
information of the user are transmitted to caretakers, from users mobile.
e. For the GPS mobile the user location is transmitted to caretakers through
POC for the users of the same network. For the users of different
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networks the transmission of SMS is through different wired networks etc.) and wireless networks (short range, broadband, cellular etc.)
2.
a. The software of users mobile is the Message Interceptor for forwarding the
SMS to group of caretakers.
b. The Protocol NMEA is used for communication between the Bluetooth
street location navigator and user's mobile.
Dated : 15th Aug 2008,
| # | Name | Date |
|---|---|---|
| 1 | 2037-CHE-2008 FORM-18 25-03-2010.pdf | 2010-03-25 |
| 1 | 2037-CHE-2008-AbandonedLetter.pdf | 2017-08-07 |
| 2 | 2037-che-2008 form-5.pdf | 2011-09-04 |
| 2 | 2037-CHE-2008-FER.pdf | 2017-01-27 |
| 3 | 2037-che-2008 abstract.pdf | 2011-09-04 |
| 3 | 2037-che-2008 form-3.pdf | 2011-09-04 |
| 4 | 2037-che-2008 claims.pdf | 2011-09-04 |
| 4 | 2037-che-2008 form-1.pdf | 2011-09-04 |
| 5 | 2037-che-2008 drawings.pdf | 2011-09-04 |
| 5 | 2037-che-2008 description (complete).pdf | 2011-09-04 |
| 6 | 2037-che-2008 description (complete).pdf | 2011-09-04 |
| 6 | 2037-che-2008 drawings.pdf | 2011-09-04 |
| 7 | 2037-che-2008 claims.pdf | 2011-09-04 |
| 7 | 2037-che-2008 form-1.pdf | 2011-09-04 |
| 8 | 2037-che-2008 abstract.pdf | 2011-09-04 |
| 8 | 2037-che-2008 form-3.pdf | 2011-09-04 |
| 9 | 2037-che-2008 form-5.pdf | 2011-09-04 |
| 9 | 2037-CHE-2008-FER.pdf | 2017-01-27 |
| 10 | 2037-CHE-2008-AbandonedLetter.pdf | 2017-08-07 |
| 10 | 2037-CHE-2008 FORM-18 25-03-2010.pdf | 2010-03-25 |
| 1 | 2037CHE2008search_19-12-2016.pdf |