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A process for the preparation of 2-(4-ethoxyphenyl)-2-methyl propylalcohol comprising the steps of:(a) acylating phenol to give phenyl isobutyrate;wherein the said acylation step is carried out with isobutyryl halide in the presence of a suitable an aprotic organic solvent and any tertiary amine base or any inorganic base at a low temperature preferably between -15°C to 50°C;(b) subjecting said phenyl isobutyrate to Fries rearrangement togive 4-hydroxyphenyl-x-methyl ethyl ketone;wherein the Fries rearrangement step is carried out in the presence of a Lewis acid such as AICI3, ZnCb, FeCk, BF3-etherate, TiCU, or the like and a solvent such as CCU, ethylene dichloride, chloroform, tetrachloro ethane or the like;(c) ethylating said 4-hydroxyphenyl-x-methyl ethyl ketone to give4-ethoxyphenyl-x-methyl ethyl ketone;wherein the ethylation step (c) is carried out in the presence of a suitable organic or inorganic base and an ethylating agent at temperature between 45°C - 100°C;(d) halogenating said 4-ethoxyphenyl-x-methyl ethyl ketone to give4-ethoxyphenyl ..x-halo-x-methyl ethyl ketone;wherein the halogenation step (d) is bromination, using a source of bromine such as liquid bromine, N-bromo succinimide or the like, in the presence of a halogenated aliphatic 02 -hydrocarbon such as carbontetrachloride, ethylyene dichloride, tetrachloroethane, or the like;(e) converting said halo ketone to halo ketal, subjecting said ketalto rearrangement to obtain an intermediate and hydrolysing thesaid intermediate to obtain 2-(4-ethoxyphenyl)-2-methylpropionic acid;wherein said step comprises treating 4-(ethoxyphenyl) -x- halo-x-methyl ethyl ketone with mono ethylene glycol in the presence of a Lewis acid, at 95-105°C, treating the halo ketal formed with a zinc salt such as zinc chloride, zinc oxide, zinc acetate, or zinc bromide in the presence of an aromatic hydrocarbon such as toluene, benzene or xylene, hydrolyzing the ester formed with methanolic alkali followed by acidification with a mineral acid such as HC1, H2SO4 or glacial acetic acid, and isolating the 2-(4-ethoxyphenyl)-2-methyl propionic acid formed.(f) converting said 2-(4-ethoxyphenyl)-2-methyl propionic acid to 2-(4-ethoxyphenyl)-2-methyl propionic acid alkyl ester, wherein said step (f) comprises treating 2-(4-ethoxyphenyl)-2-methyl propionic acid with an alcohol such as methanol, ethanol, propanol, butanol or the like, in the presence of an acid such as sulphuric acid, hydrochloric acid, phosphoric acid or the like, at 60°C to 70°C to give 2-(4-ethoxyphenyl)-2-methyl propionic acid alkyl ester, and(g) treating said alkyl ester with an alkali metal in the presence of an alcohol to give 2-(4-ethoxyphenyl)-2-methyl propyl alcohol, wherein said step (g) comprises treating 2-(4-ethoxyphenyl)-2-methyl propionic acid alkyl ester with an alkali metal such as sodium, potassium or lithium, in the presence of an alcohol.
Notices, Deadlines & Correspondence
Patent Information
Applicants
ISAGRO (ASIA) AGROCHEMICALS PRIVATE LIMITED
Inventors
1. RPG LIFE SCIENCES LIMITED
2. SHRIKANT SADANAND SAKHALKAR
3. CHETAN RAMA SHANBHAG
4. TARUR VENKATASUBRAMANIAM RADHAKRISHNAN
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | in-pct-2002-00812-mum-form 19(28-11-2004).pdf | 2004-11-28 |
| 2 | in-pct-2002-00812-mum-form 2(granted)-(11-05-2005).doc | 2005-05-11 |
| 4 | IN-PCT-2002-00812-MUM-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(06-12-2006).pdf | 2006-12-06 |
| 5 | IN-PCT-2002-00812-MUM-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(19-11-2008).pdf | 2008-11-19 |
| 6 | IN-PCT-2002-00812-MUM-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(12-12-2011).pdf | 2011-12-12 |
| 7 | IN-PCT-2002-00812-MUM-CORRESPONDENCE-(13-12-2013).pdf | 2013-12-13 |
| 8 | IN-PCT-2002-00812-MUM-CORRESPONDENCE(10-12-2014).pdf | 2014-12-10 |
| 9 | IN-PCT-2002-00812-MUM-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(08-12-2015).pdf | 2015-12-08 |
| 10 | IN-PCT-2002-00812-MUM-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(13-12-2016).pdf | 2016-12-13 |
| 11 | 196179-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-07-12-2017.pdf | 2017-12-07 |
| 12 | in-pct-2002-00812-mum-power of authority(17-5-2005).pdf | 2018-08-08 |
| 13 | in-pct-2002-00812-mum-petition under rule 138(19-5-2005).pdf | 2018-08-08 |
| 14 | in-pct-2002-00812-mum-form-pct-isr-210(11-5-2005).pdf | 2018-08-08 |
| 15 | in-pct-2002-00812-mum-form-pct-ipea-409(11-5-2005).pdf | 2018-08-08 |
| 16 | in-pct-2002-00812-mum-form 3(17-6-2002).pdf | 2018-08-08 |
| 17 | in-pct-2002-00812-mum-form 2(granted)-(11-5-2005).pdf | 2018-08-08 |
| 18 | in-pct-2002-00812-mum-form 1a(17-6-2002).pdf | 2018-08-08 |
| 19 | in-pct-2002-00812-mum-drawing(11-5-2005).pdf | 2018-08-08 |
| 20 | in-pct-2002-00812-mum-correspondence(ipo)-(30-9-2005).pdf | 2018-08-08 |
| 21 | in-pct-2002-00812-mum-correspondence(18-5-2005).pdf | 2018-08-08 |
| 22 | in-pct-2002-00812-mum-claims(granted)-(11-5-2005).pdf | 2018-08-08 |
| 23 | in-pct-2002-00812-mum-cancelled pages(11-5-2005).pdf | 2018-08-08 |
| 24 | abtract1.jpg | 2018-08-08 |