Claims:WE CLAIM:

1. An improved process for the preparation of 4-Phenylmorpholin-3-one by reacting 2-(phenyl amino) ethanol in methanolic solution with 2 equivalents of 2-chloroacetyl chloride and 4 equivalents of base.

2. The process as claimed in claim 1, the base is selected from such as sodium hydroxide and potassium hydroxide.
3. The process as claimed in claim 1, the methanolic solution selected from such as mixture of methanol and water.
4. The process as claimed in claim 1, 2-(phenylamino)ethanol is charged in aqueous mthanolic solution from methanol and water, 1.5 to 2 equivalents of chloroacetylchloride and 3 to 4 equivalents of base.
5. The process as claimed in claim 1, wherein chloroacetylchloride and base solution are added at an internal temperature of 25-30ºC and while maintain a pH of the reaction solution between 9-10.
6. The process as claimed in Claim 1, where the reaction is carried over at 25 to 30°C.

, Description:DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to an improved process for the preparation of process for the preparation of 4-Phenylmorpholin-3-one.

In one embodiment of the present invention, provides an process for the preparation of 4-Phenylmorpholin-3-one by reacting 2-(phenyl amino) ethanol in methanolic solution (methanol and water) with 2 equivalents of 2-chloroacetyl chloride and 4 equivalents of base.

According to the embodiment of the present invention process for the preparation of 4-phenylmorpholin-3-one, which comprises 2-(phenylamino)ethanol was dissolved in methanol and water at room temperature. The reaction mass was heated to 25-32ºC. 1.5 to 2 equivalents of chloroacetyl chloride and 3 to 4 equivalents 45% sodium hydroxide solution are then added simultaneously at an internal temperature of 25 to 30°C for 40 to 60 minutes. The obtain filtrate pH 9 to 10.5 was adjusted with aq. sodium hydroxide, then cooled to 2ºC and stirred at this temperature for 20 minutes. The resultant precipitate was filtered, washed with water to afford a 4-Phenylmorpholin-3-one

According to the embodiment of the present invention provides, wherein the base is selected from such as sodium hydroxide and potassium hydroxide.

According to the embodiment of the present invention provides, wherein the methanolic solution selected from such as mixture of methanol and water.

According to the embodiment of the present invention provides, wherein the process 2-(phenylamino)ethanol is charged in aqueous mthanolic solution from methanol and water, 1.5 to 2 equivalents of chloroacetylchloride and 3 to 4 equivalents of base.

According to the embodiment of the present invention provides, wherein chloroacetylchloride and base solution are added at an internal temperature of 25-30ºC and while maintain a pH of the reaction solution between 9-10. The entire reaction is carried out at 25 to 32 °C

The following examples illustrate the present invention, but should not be construed as limiting the scope of the invention.