PREAMBLE TO TH E DESCRIPTION
The present invention is the specific formulation ofthe extract and nanoemulsion for cancer
treatment.
DESCRIPTION
Background ofthc Invention
Cancer is a condition brought on by aberrant cells growing and dividing out of control‘
It is a kind ofdiseasc were can attack any organ, or tissue in the body where the malignant cells
grow recklessly, beyond their customaly limiKs to infiltrate surrounding bodily regions and/or
extend to alternative organs. The latter phase, known as metastasizing, is a primary contributor
to cancer-related deaths
Cancer is the second most widely causing death worldwide, in recent studies cancer is
the biggest factor for monality worldwide, accounting for around 10 million fatalities There
were 2.26 million instances ofbreasl cancer, 2.2l million cases oflung cancer, I .93 million of
colon and rectum, l.4l million cases of prostate cancer, and 1.20 million cases of skin cancer‘
Compared to other diseases cancer causes more mortality. Lung cancer causes LS million
deaths, 0.9 million deaths from colon and rectum cancer, "083 million deaths due to liver
cancer: 0.76 million deaths due to stomach cancer, and 0.68 million deaths due to breast cancer,
Nearly 0.4 million kids and youngsters are diagnosed with cancer evmy yea]: The most
prevalent malignancies differ worldwide, nearly 23 nations have cervical cancer diagnosed
commonly. Mostly the cancer is caused by the mutation of genes. It is caused by exposure to
chemicals, radiation, or other substances as well as our lifestyle behavior like dict, physical
' 4 activity, obesity, drugs, and alcohol consumption, not properly diagnosing the disease. Mostly
it causes pain and fatigue, anemia, mouth problems, nausea/weight change/dicta“)! issues, and
hair, skin, nail problems, and pain. To prevent the disease one should follow a healthy diet,
avoid excessive sun exposure, eat a healthy diet, do physical activity, and avoid alcohol. Here
to propose a solution to the cancer, made formulations using the Parmotrema perlamm, a fungi
group that is commonly known in Tamil as Kalpasi. Most Indian spices can control tumor cells.
So by using it made a microemulsion and a nanoemulsion to cure the cancer.
DISCLOSURE OF THE INVENTION:
Reference may be made to patent number W02008016664A2 by UNIVERSITY OF
MASSACHUSETTS LOWELL; NICOLOSI, ROBERT; TAGNE, JEAN—BOSCO titled
“COMPOSITIONS AND METHODS FOR TREATING CANCER WITH DACARBAZINE
NANOEMULSIONS”. The present invention refers to a uniform microfluidizcd nanoemulsion
is disclosed containing an anti-cancer agent, such as dacarbazine. The microfluidized
nanoemulsion improves the combination's cell membrane permeability by at least four—fold
over conventional nanoemulsion compositions, which significantly increases the intracellular
concentration ofanti—cancer agents. As a nanoemulsion, dacarbazine has a greater anti-cancer
efficacy than when applied as a free solution.
Reference may be made lo patent number CNI |40|067|A by UNIVERSITY OF
MASSACHUSETTS LOWELL; NICOLOSI, ROBERT; ’I‘AGNE, JEAN—BOSCO titled
“Black ginseng nano—emulsion for treating melanoma us well as preparation method and
application of black ginseng nano-cmulsion". Tb; present invention belongs to the technical
field ofexternal medicines for treating melanoma, and discloses a black ginseng nanoemulsion
for treating melanoma as well as a preparation method and application of the black ginseng
nanoemulsion. Comprising the following steps: preparing black ginseng paste by using
ullrapurc water; adding the oil phase, the emulsifier and the co-emulsifier into ajaw bottle, and
stirring; adding the black ginseng paste solution, and stifling; and homogenizing by using an
ultrahigh-pressure homogenizcr to enable the medicine to achieve dissolution balance, thercby
obtaining the medicine. According to the invention, on the basis ofrescarch on the composirion
and activity of the scrophularia ningpoensis, the product is preparcd into a scrophularia
ningpoensis nanoemulsion preparation, so that the aim of slow release of the medicine is
Fulfilled; a malignant melanoma mouse model is built; the research and development work of
new drugs and novel functional foods of effective componems is carried out by utilizing
corresponding research results, so that the inherent quality ofthc product is controlled, and a
theoretical basis is provided for cffcctivc; reasonable and safe use oflhc product. According to
the black ginseng nanocmulsion prepared by the invention, the content of Rg3 is measured to
be 84.25 mu g/mL, the content of RgS is measured to be 22.75 mu g/mL, and the anti-cancer
effect is greatly improved.
Reference may be made to patent number KRIOI442 l 4] Bl by KIM TAE JIN titled “HERBAL
MEDICINE COMPOSITION FOR ANTI-CANCER AND FORMS THEREOF? The present
invention disclosed are an anti—cancer herbal medicine composition and a herbal medicine
fonnulalion for mitigating cancer and improving tremment. The herbal medicine composition,
according to an embodiment of the present invention, comprises Astragalus membranaccus,
Smilacis chinae, Euphoria longana, Akebia quinula, gastrodia, betel nut, sanguisorba r001;
amana root, portulaca, pyrrosia, taraxacum herb, licorice, canhworms, toad, and lonicer
aflower for anti—cancer, mitigating cancer, and improving treatment for lung cancer, stomach
cancer, colon cancer, liver cancer, pancreatic cancer, breast cancer, cervical cancer, and blood
cancer.
Reference may be made to patent number EP32|6869A1 by ClRlLLO, Marco; GALGANI,
Andrea; DEL GALLO DI ROCCAGIOVINE= Flavia; KENZO, Maurice; MINUTOLO,
Antonella; MONTESANO, Carla; MULEO, Rosario; PIRRO, Stefano; POTESTA, Marina;
MATIC, Ivana titled “NU'I‘RACEUTICAL PLANT DERIVED MICRORNA ELEMENTS
FOR TREATMENT OF LEUKEMIA”. The present invention is a use of plant—(lcrivcd miRNA
molecule or its synthetic equivalent, selected from amongst plant—miR—ZO, plant-miR—27, plantaR-
34 or plant-miR-I6Sa, for decreasing tumor proliferation by regulating expression of
cancer-related proteins in humans. An isolated plant-functional microRNA or an extract
containing said plant-functional microRNA, a preparation method therefore, and an application
thereof are provided. More particularly, the invention concems the use of an water-soluble
extract oft Moninga oleifcra plant seeds, as active principle, on its own or combined with at
least another active principle, for preparing a nutraceutical composition used for treating or
preventing cancer. The composition is easily absorbed in the cells, and has beneficial
advantages selectively toxic for cancer but not normal cells. The invention therefore delivers a
novel therapeutic method based on endogenous or synthetic plant-functional microRNAs
capable of regulating mammalian SlRT-I pathway associated non—plant (angel—genes and
decreasing proliferation of human cancer cells.
CLAIMS :
Preparation of extract using Parmotrcma perlatum
2. According to claim I, the Parmotrema perlatum has made into powder and extract is
prepared using ethanol, then subjected to various assay and to leam its property.
3. The formulation of nano emulsion was prepared.
4. According to claim 3, the Parmotrema perlamm solvent is prepared and dried.
5. According to claims 4, then it is added to oil in water emulsion.
6. The prepared emulsion from claim 3 will be in uln‘asonication process for 30 mins.
7‘ The prepared nano-emulsion from claim 6, was then subjected to various assay and to
learn its property.