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Process For Preparation Of Pharmaceutical Composition Containing Antiretroviral Protease Inhibitor With Improved Bioavailability
Abstract: PROCESS FOR MANUFACTURING PHARMACEUTICAL COMPOSITION CONTAINING ANTIRETROVIRAL PROTEASE INHIBITOR WITH IMPROVED BIOAVAILABILITY The present invention relates to a process for manufacturing pharmaceutical composition containing antiretroviral inhibitor with improved bioavailability.According to present invention it is possible to improve bioavailability of protease inhibitors like Saquinavir,Indinavir,Lopinavir,Amprewnavir but it is not possible to improve bioavailability of Ritanovir.The incorportion of Piperine,its metabolites or structural analogues or isomers thereof with antiretoviral protease inhibitor/s results in a synergistic composition having unexpected increased bioavailability of antireetroviral protease inhibitor/s.It is also to be noted that Piperine or its metaboilites or structural analogues or isomers thereof has no pharmacological properties.The quantity of Piperine typically requried for this ranges up to 30 mgm per dosage from to be administered.Increasing the amount of Piperine beyond this does not improve the bioavailability of the drug further.Like excipients used in pharamaceutical composition,Piperine is not found to have any therapeutic effect in management of HIV when used in this amount.It is also not found to affect chemical composition of a drug when combind with it in a singal pharmaceutical composition. The pharamaceutical composition incorporating may be prepared in the form of liquid,powder,capsule or tablet or any other desired dosage form. The improved bioavailability of the drug is heplful in reducing the amount of the drug to be consumed as well as no and or frequency of dosage from to be consumed.This is a much desired effect and helps in improving compliance of patient.
Notices, Deadlines & Correspondence
Patent Information
Applicants
CADILA PHARMACEUTICAL LTD
Inventors
1. Indravadan A Modi
2. Bakulesh Mafatlal Khamar,
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 325-mum-2002-claims(amended)-(14-12-2007).pdf | 2007-12-14 |
| 2 | 325-mum-2002-cancelled pages(14-12-2007).pdf | 2007-12-14 |
| 3 | 325-mum-2002-correspondence(ipo)-(20-12-2007).pdf | 2007-12-20 |
| 4 | 325-mum-2002-wo international publication report(4-4-2003).pdf | 2018-08-08 |
| 5 | 325-mum-2002-form 5(4-4-2003).pdf | 2018-08-08 |
| 6 | 325-mum-2002-form 3(6-2-2006).pdf | 2018-08-08 |
| 7 | 325-mum-2002-form 3(4-4-2003).pdf | 2018-08-08 |
| 8 | 325-mum-2002-form 3(4-4-2002).pdf | 2018-08-08 |
| 9 | 325-mum-2002-form 2(title page)-(provisional)-(4-4-2002).pdf | 2018-08-08 |
| 10 | 325-mum-2002-form 2(title page)-(complete)-(4-4-2003).pdf | 2018-08-08 |
| 11 | 325-mum-2002-form 2(provisional)-(4-4-2002).pdf | 2018-08-08 |
| 12 | 325-mum-2002-form 2(complete)-(4-4-2003).pdf | 2018-08-08 |
| 13 | 325-mum-2002-form 18(28-2-2006).pdf | 2018-08-08 |
| 14 | 325-mum-2002-form 1(4-4-2003).pdf | 2018-08-08 |
| 15 | 325-mum-2002-form 1(4-4-2002).pdf | 2018-08-08 |
| 16 | 325-mum-2002-form 1(3-4-2003).pdf | 2018-08-08 |
| 17 | 325-mum-2002-form 1(1-7-2002).pdf | 2018-08-08 |
| 18 | 325-mum-2002-drawing(provisional)-(4-4-2002).pdf | 2018-08-08 |
| 19 | 325-mum-2002-description(provisional)-(4-4-2002).pdf | 2018-08-08 |
| 20 | 325-mum-2002-description(complete)-(4-4-2003).pdf | 2018-08-08 |
| 21 | 325-mum-2002-correspondence(ipo)-(31-3-2011).pdf | 2018-08-08 |
| 22 | 325-mum-2002-correspondence(3-4-2003).pdf | 2018-08-08 |
| 23 | 325-mum-2002-correspondence(1)-(1-8-2008).pdf | 2018-08-08 |
| 24 | 325-mum-2002-claims(4-4-2003).pdf | 2018-08-08 |
| 25 | 325-mum-2002-abstract(4-4-2003).pdf | 2018-08-08 |