Sign In to Follow Application
View All Documents & Correspondence

Process For Refining Impure Silver Bullion .

Abstract: Disclosed is a method for quality control of an attenuated varicella live vaccine, which comprises analyzing the genomic DNA of a sample varicella vaccine virus, wherein the sample varicella vaccine virus is a virus for use as an active ingredient of an attenuated varicella live vaccine; and confirming that the genomic DNA of the sample varicella vaccine virus conserves the 5,745th G, the 105,356th C, the 105,544th G, the 106,262nd C and the 107,252nd C without suffering mutation, wherein the nucleotide numbers are in accordance with the nucleotide numbering system of the nucleotide sequence of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO: 1.

Get Free WhatsApp Updates!
Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
02 July 2002
Publication Number
20/2008
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2009-04-01
Renewal Date

Applicants

UMICORE
RUE DU MARAIS 31, B-1000 BRUSSELS

Inventors

1. VANHOUTTE DIRK
C/O UMICORE (FORMERLY N. V. UNION MINIERE S. A.) PATENT DEPARTMENT KASTEELSTRAAT 7, B-2250 OLEN
2. BROUWER SYBOLT
C/O UMICORE (FORMERLY N. V. UNION MINIERE S. A.) PATENT DEPARTMENT KASTEELSTRAAT 7, B-2250 OLEN

Specification

TITLE OF THE INVENTION Method for quality control of an attenuated varicella live vaccine BACKGROUND OF THE INVENTION Field of the Invention The present invention relates to a method for quality control of an attenuated varicella live vaccine. More particularly, the present invention relates to a method for quality control of an attenuated varicella live vaccine, which comprises subjecting the genomic DNA of a sample varicella vaccine virus to sequence analysis and confirming that the genomic DNA of the sample varicella vaccine virus conserves the specific nucleotides without suffering mutation. By the use of the method of the present invention, it has become pos- sible to determine very accurately the qualification of an attenuated varicella virus as an active ingredient of an attenuated varicella live vaccine and, conse- quently, to conduct an exact quality control of the vaccines. Prior Art As is well known, attenuated varicella live vac- cines used today are produced from a seed strain of varicella virus which is derived from the attenuated varicella virus Oka strain (see Examined Japanese Pat- ent Application Publication No. 53-41202 and U.S. Pat- ent No. 3,985,615), and the attenuated live vaccines are used widely throughout the world (Requirements for Varicella Vaccine (Live) Adopted 1984; Revised 1993: WHO Technical Report Series, No. 848, pp. 22-38, 1994). To ensure the safety and effectiveness of the vaccine, the number of passages of a virus used for producing the vaccine is restricted under the control of a seed lot system, taking into consideration the potential ge- netic mutation which is likely to occur during the pas- sage. That is, the manufacturers are under an obliga- tion to produce varicella vaccines only from the virus derived from the approved seed virus for the live vari- cella vaccine, wherein the number of passages of the virus is not more than 10 as counted from the approved seed virus which is counted as 0 passage. In other words, the quality control and quality assurance of the attenuated varicella live vaccine rely upon the ful- fillment of the seed lot system by the manufacturers, and such a method for the quality control and quality assurance is not a method which can be traced and ana- lyzed by a person skilled in the art. Further, from the viewpoint of epidemiology which involves a tracing of the effects of the varicella vac- cine and a post-market surveillance (PMS), the vi- rological difference between the fresh wild-type strains isolated from the naturally infected varicella patients and the vaccine virus strains derived from the above-mentioned Oka strain needs to be determined, and various analyses, such as those utilizing immunological techniques and genetic engineering techniques, have been attempted for determination of the virological difference. For example, the following analyses have been reported: the difference in DNA sequence between the various VZV strains (Journal of Virology, 59, 660- 668, 1986; and

Documents

Application Documents

# Name Date
1 in-pct-2002-888-kol-granted-specification.pdf 2011-10-08
2 in-pct-2002-888-kol-granted-reply to examination report.pdf 2011-10-08
3 in-pct-2002-888-kol-granted-gpa.pdf 2011-10-08
4 in-pct-2002-888-kol-granted-form 5.pdf 2011-10-08
5 in-pct-2002-888-kol-granted-form 3.pdf 2011-10-08
6 in-pct-2002-888-kol-granted-form 2.pdf 2011-10-08
7 in-pct-2002-888-kol-granted-form 18.pdf 2011-10-08
8 in-pct-2002-888-kol-granted-form 1.pdf 2011-10-08
9 in-pct-2002-888-kol-granted-examination report.pdf 2011-10-08
10 in-pct-2002-888-kol-granted-description (complete).pdf 2011-10-08
11 in-pct-2002-888-kol-granted-correspondence.pdf 2011-10-08
12 in-pct-2002-888-kol-granted-claims.pdf 2011-10-08
13 in-pct-2002-888-kol-granted-assignment.pdf 2011-10-08
14 in-pct-2002-888-kol-granted-abstract.pdf 2011-10-08
15 IN-PCT-2002-888-KOL-FORM 27.pdf 2011-10-08
16 IN-PCT-2002-888-KOL-FORM 27 1.1.pdf 2011-10-08
17 IN-PCT-2002-888-KOL-CORRESPONDENCE 1.1.pdf 2011-10-08
18 IN-PCT-2002-888-KOL-FORM-27.pdf 2013-04-12
19 IN-PCT-2002-888-KOL-(28-03-2016)-FORM-27.pdf 2016-03-28
20 Form 27 [20-03-2017(online)].pdf 2017-03-20
21 IN-PCT-2002-888-KOL-RELEVANT DOCUMENTS [19-03-2018(online)].pdf 2018-03-19
22 IN-PCT-2002-888-KOL-RELEVANT DOCUMENTS [27-03-2019(online)].pdf 2019-03-27
23 IN-PCT-2002-888-KOL-RELEVANT DOCUMENTS [21-03-2020(online)].pdf 2020-03-21
24 IN-PCT-2002-888-KOL-04-01-2023-ALL DOCUMENTS.pdf 2023-01-04

ERegister / Renewals

3rd: 01 Jun 2009

From 17/01/2003 - To 17/01/2004

4th: 01 Jun 2009

From 17/01/2004 - To 17/01/2005

5th: 01 Jun 2009

From 17/01/2005 - To 17/01/2006

6th: 01 Jun 2009

From 17/01/2006 - To 17/01/2007

7th: 01 Jun 2009

From 17/01/2007 - To 17/01/2008

8th: 01 Jun 2009

From 17/01/2008 - To 17/01/2009

9th: 01 Jun 2009

From 17/01/2009 - To 17/01/2010

10th: 04 Jan 2010

From 17/01/2010 - To 17/01/2011

11th: 28 Dec 2010

From 17/01/2011 - To 17/01/2012

12th: 28 Dec 2011

From 17/01/2012 - To 17/01/2013

13th: 07 Dec 2012

From 17/01/2013 - To 17/01/2014

14th: 06 Dec 2013

From 17/01/2014 - To 17/01/2015

15th: 11 Dec 2014

From 17/01/2015 - To 17/01/2016

16th: 11 Dec 2015

From 17/01/2016 - To 17/01/2017

17th: 05 Dec 2016

From 17/01/2017 - To 17/01/2018

18th: 01 Dec 2017

From 17/01/2018 - To 17/01/2019

19th: 11 Dec 2018

From 17/01/2019 - To 17/01/2020

20th: 06 Dec 2019

From 17/01/2020 - To 17/01/2021