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Process For The Modulation Of The Antagonistic Activity Of A Monoclonal Antibody
Abstract: The present disclosure relates to the antibody engineering field and, more particularly, to a process for the screening of antibodies and/or the modulation of the agonistic/antagonistic activity of antibodies. More particularly, the disclosure concerns a process of improving the antagonistic activity of a monoclonal antibody directed against a specific target molecule, or a divalent functional fragment or derivative thereof, said antibody being capable of inhibiting one or more of the biological activities of said target molecule, wherein said process comprises a stage of reconfiguration of the hinge region consisting of a modification of the amino acid sequence of said hinge region by the deletion, the addition or the substitution of at least one amino acid. The disclosure also relates to polypeptides useful for such a modulation method and the obtained antibodies.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
20 May 2011
Publication Number
13/2012
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2019-06-28
Renewal Date
Applicants
PIERRE FABRE MEDICAMENT
45, PLACE ABEL GANCE, F-92100 BOULOGNE-BILLANCOURT, FRANCE,
Inventors
1. GOETSCH, LILIANE
15, ROUTE DE CLUSES, F-74130 AYZE, FRANCE,
2. WURCH, THIERRY
7 ROUTE DES ETOLES, LE CLOS BELLEVUE, F-74140 MACHILLY, FRANCE,
Specification
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
| 15 | Sapna Narvariya | 2019-06-28 |
| 15 | Sapna Narvariya | 2019-06-28 |
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 3806-delnp-2011-GPA-(06-06-2011).pdf | 2011-06-06 |
| 2 | 3806-delnp-2011-Correspondence Others-(06-06-2011).pdf | 2011-06-06 |
| 3 | 3806-delnp-2011-Form-1-(22-06-2011).pdf | 2011-06-22 |
| 4 | 3806-delnp-2011-Correspondence Others-(22-06-2011).pdf | 2011-06-22 |
| 5 | 3806-delnp-2011-Form-3-(06-09-2011).pdf | 2011-09-06 |
| 6 | 3806-delnp-2011-Correspondence-Others-(06-09-2011).pdf | 2011-09-06 |
| 7 | 3806-delnp-2011-Form-5.pdf | 2012-01-27 |
| 8 | 3806-delnp-2011-Form-3.pdf | 2012-01-27 |
| 9 | 3806-delnp-2011-Form-2.pdf | 2012-01-27 |
| 10 | 3806-delnp-2011-Form-1.pdf | 2012-01-27 |
| 11 | 3806-delnp-2011-Drawings.pdf | 2012-01-27 |
| 12 | 3806-delnp-2011-Description (Complete).pdf | 2012-01-27 |
| 13 | 3806-delnp-2011-Correspondence Others.pdf | 2012-01-27 |
| 14 | 3806-delnp-2011-Claims.pdf | 2012-01-27 |
| 15 | 3806-delnp-2011-Abstract.pdf | 2012-01-27 |
| 16 | 3806-delnp-2011-Form-18-(22-11-2012).pdf | 2012-11-22 |
| 17 | 3806-delnp-2011-Correspondence Others-(22-11-2012).pdf | 2012-11-22 |
| 18 | 3806-DELNP-2011-FER.pdf | 2017-08-28 |
| 19 | 3806-delnp-2011-Retyped Pages under Rule 14(1) (MANDATORY) [26-02-2018(online)].pdf | 2018-02-26 |
| 20 | 3806-delnp-2011-OTHERS [26-02-2018(online)].pdf | 2018-02-26 |
| 21 | 3806-delnp-2011-Information under section 8(2) (MANDATORY) [26-02-2018(online)].pdf | 2018-02-26 |
| 22 | 3806-DELNP-2011-FORM 3 [26-02-2018(online)].pdf | 2018-02-26 |
| 23 | 3806-delnp-2011-FER_SER_REPLY [26-02-2018(online)].pdf | 2018-02-26 |
| 24 | 3806-delnp-2011-CLAIMS [26-02-2018(online)].pdf | 2018-02-26 |
| 25 | 3806-delnp-2011-2. Marked Copy under Rule 14(2) (MANDATORY) [26-02-2018(online)].pdf | 2018-02-26 |
| 26 | 3806-DELNP-2011-HearingNoticeLetter.pdf | 2019-03-08 |
| 27 | 3806-DELNP-2011-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [04-04-2019(online)].pdf | 2019-04-04 |
| 28 | 3806-DELNP-2011-ExtendedHearingNoticeLetter_07May2019.pdf | 2019-04-04 |
| 29 | 3806-DELNP-2011-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [03-05-2019(online)].pdf | 2019-05-03 |
| 30 | 3806-DELNP-2011-ExtendedHearingNoticeLetter_06Jun2019.pdf | 2019-05-06 |
| 31 | 3806-DELNP-2011-ExtendedHearingNoticeLetter_14Jun2019.pdf | 2019-05-24 |
| 32 | 3806-DELNP-2011-FORM-26 [12-06-2019(online)].pdf | 2019-06-12 |
| 33 | 3806-DELNP-2011-Correspondence to notify the Controller (Mandatory) [12-06-2019(online)].pdf | 2019-06-12 |
| 34 | 3806-DELNP-2011-Written submissions and relevant documents (MANDATORY) [26-06-2019(online)].pdf | 2019-06-26 |
| 35 | 3806-delnp-2011-Sequence listing [26-06-2019(online)].txt | 2019-06-26 |
| 36 | 3806-DELNP-2011-Retyped Pages under Rule 14(1) (MANDATORY) [26-06-2019(online)].pdf | 2019-06-26 |
| 37 | 3806-delnp-2011-Response to office action (Mandatory) [26-06-2019(online)].pdf | 2019-06-26 |
| 38 | 3806-DELNP-2011-PETITION UNDER RULE 137 [26-06-2019(online)].pdf | 2019-06-26 |
| 39 | 3806-DELNP-2011-FORM 3 [26-06-2019(online)].pdf | 2019-06-26 |
| 40 | 3806-DELNP-2011-Annexure (Optional) [26-06-2019(online)].pdf | 2019-06-26 |
| 41 | 3806-DELNP-2011-2. Marked Copy under Rule 14(2) (MANDATORY) [26-06-2019(online)].pdf | 2019-06-26 |
| 42 | 3806-DELNP-2011-PatentCertificate28-06-2019.pdf | 2019-06-28 |
| 43 | 3806-DELNP-2011-IntimationOfGrant28-06-2019.pdf | 2019-06-28 |
| 44 | 3806-DELNP-2011-Power of Attorney-130619.pdf | 2019-07-02 |
| 45 | 3806-DELNP-2011-Correspondence-130619.pdf | 2019-07-02 |
| 46 | 3806-DELNP-2011-RELEVANT DOCUMENTS [17-03-2020(online)].pdf | 2020-03-17 |
| 47 | 3806-DELNP-2011-RELEVANT DOCUMENTS [27-08-2021(online)].pdf | 2021-08-27 |
| 48 | 3806-DELNP-2011-RELEVANT DOCUMENTS [28-07-2022(online)].pdf | 2022-07-28 |
| 49 | 3806-DELNP-2011-RELEVANT DOCUMENTS [06-09-2023(online)].pdf | 2023-09-06 |
Search Strategy
| 1 | 3806-DELNP-2011_21-08-2017.pdf |