Process For The Preparation Of A Single Enantiomer Of 3

Process For The Preparation Of A Single Enantiomer Of 3 Aminopiperidine Dihydrochloride

Abstract: A process comprising: (a) reduction of N-acetyl-3-aminopyridine (2): or its salt in the presence of hydrogen and a palladium catalyst deposited on solid support; (b) converting racemic N-acetyl-3-aminopiperidine (3) or its salt produced in step (a) to rac-3-aminopiperidine (rac-4) or its salt; (c) resolution of the racemic 3-aminopiperidine (rac-4) or its salt produced in step (b) with a chiral acid.

Patent Information

Application #

Filing Date

07 December 2012

Publication Number

46/2015

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

Dr. Reddy’s Laboratories Limited

8-2-337 Road No. 3 Banjara Hills Hyderabad 500034 Andhra Pradesh India

Dr.Reddy’s Laboratories Inc.

200 Somerset Corporate Boulevard Seventh Floor Bridgewater New Jersey-08807 USA.

Inventors

1. Meek Graham Andrew

32 Tower Court Tower Road Ely Cambridgeshire CB7 4XS (GB)

2. Kunhimon Syam Kumar Unniaran Purakkal

Thanka Nivas P.O. Nattika Thrissur Kerala (IN)

3. Shankar R.

9/2 Tharamangalam Main Road Old Suramangalam Salem – 636 005

4. Dahanukar Vilas Hareshwar

Plot No. 11 Lalitha Bloomfield Nanakramguda Next to Oakridge School Khajaguda Hyderabad – 500008.

5. Mohan TH. Krishna

Custom Pharmaceutical Services Bollaram Road Miyapur Hyderabad – 500049 Andhra Pradesh (IN)

6. Wagh Manoj Balu

Matoshri Bunglow S. No. 908/33/B Wasan Nagar Nashik Maharashtra (IN)

7. Pal Abir Kumar

Vill – Jambuni P.O. Bolpur Dist. Birbhum 731 204 West Bengal (IN)

8. Meesala V. Madhu Babu

S.O. Gangadharararo Near Panchayath Office Gopalapuram RVPM East Godavari District 533274

9. Sonmit Shrivastava

G-1 Gokul Residency Jayanagar Colony Near St. Alphonsa’s School KPHB Kukatpally Hyderabad – 500 074 Andhra Pradesh (IN)

Specification

The following specification particularly describes the nature of the invention and the manner in which it is to be performed.

13. The process of claim 7 further comprising acid exchange directly from the partially resolved 3-aminopiperidine dibenzoyl-(D)-tartaric acid salt (5):

with hydrogen chloride in isopropyl alcohol/water as the solvent.
14. The process of claim 8 wherein the acetylating of 3-aminopyridine (1) is performed in the presence of acetic acid propionic acid or butanoic acid.
15. The process of claim 14 wherein the acetylating of 3-aminopyridine (1) is performed in the presence of acetic acid.
16. The process of claim 8 wherein the salt of N-acetyl-3-aminopyridine (2) is the acetate propionate or butanoate.
17. The process of claim 16 wherein the salt of N-acetyl-3-aminopyridine (2) is acetate salt.

Documents

Application Documents

#	Name	Date
1	10275-CHENP-2012-AbandonedLetter.pdf	2018-06-07
2	10275-CHENP-2012-FER.pdf	2017-11-27
3	abstract 10275-CHENP-2012.jpg	2014-12-19
4	ABSTRACT.pdf	2014-12-19
4	FORM-2.pdf	2014-12-19
5	ABSTRACT.pdf	2014-12-19
5	FORM-2.pdf	2014-12-19
6	abstract 10275-CHENP-2012.jpg	2014-12-19
7	10275-CHENP-2012-FER.pdf	2017-11-27
8	10275-CHENP-2012-AbandonedLetter.pdf	2018-06-07

Search Strategy

1	Search_Strategy_10275_CHENP_2012_17-11-2017.PDF