Process For The Preparation Of Clopidogrel Hydrochloride

Abstract: The present invention provides a process for a preparation of clopidogrel hydrochloride from clopidogrel chiral auxiliary, wherein the said process comprises of, a) Converting salt of clopidogrel chiral auxiliary to clopidogrel base in organic solvent b) to the reaction mixture of step a) added alcoholic hydrochloride c) isolating clopidogrel hydrochloride from the reaction mass thereof

Patent Information

Application #

Filing Date

01 December 2006

Publication Number

31/2008

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

WOCKHARDT LIMITED

WOCKHARDT TOWERS, BANDRA-KURLA COMPLEX, BANDRA (EAST), MUMBAI 400 051,

Inventors

1. KHAN ANJUM REYAZ

FLAT NO. 7, CRYSTAL OPP. COLLECTOR'S OFFICE, MOHANLAL NAGAR, AURANGABAD 431001,

2. SHUKLA JAGDISH DATTOPANT

Appol-Z.P. Girl's High School Station Road, Parbhani 431001

3. MERWADE ARVIND YEKANATHSA

C/o. Y.K.Merwade, Rajendra Prasad Road, Gadag, Betgeri 582102

4. SIDDIQUI MOHAMMED JAWEED MUKARRAM

H. No. 4-8-65, Nawabpura, Near Nagina Masjid, Aurangabad 431 001

Specification

FORM 2
THE PATENT ACT 1970
(39 of 1970)
&
The Patents Rules, 2003
COMPLETE SPECIFICATION
(See section 10 and rulel3)
1. TITLE OF THE INVENTION:
PROCESS FOR THE PREPARATION OF CLOPIDOGREL
HYDROCHLORIDE
2. APPLICANT (S)
(a) NAME: WOCKHARDT LTD.
(b) NATIONALITY: INDIAN
(c) ADDRESS: Wockhardt Towers, Bandra-Kurla Complex, Bandra (East),
Mumbai - 400 051.
3. PREAMBLE TO THE DESCRIPTION
The present invention provides a process for the preparation of clopidogrel
hydrochloride.
The following specification particularly describes the invention and the manner
in which it is to be performed.
1

4. DESCRIPTION
The present invention provides a process for the preparation of clopidogrel hydrochloride.
Clopidogrel hydrochloride of formula I is chemically known as, methyl (+)-(S)-