"Prostaglandin E2 Binding Proteins And Uses Thereof"

Abstract: The present invention encompasses prostaglandin ET (PGE2) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E2 and neutralize prostaglandin E2 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E: and for inhibiting prostaglandin E2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E2 activity is detrimental.

Patent Information

Application #

Filing Date

27 December 2010

Publication Number

10/2012

Publication Type

INA

Invention Field

TRADITIONAL KNOWLEDGE BIOTECHNOLOGY

Status

Email

Parent Application

Applicants

ABBOTT LABORATORIES

100 ABBOTT PARK ROAD, ABBOTT PARK, IL 60064, U.S.A.

Inventors

1. GU JIJIE

12 TERN DRIVE, SHREWSBURY, MA 01545 U.S.A

2. HUTCHINS CHARLES W.

31005 PRARIE RIDGE ROAD, GREEN OAKS, IL 60048 U.S.A.

3. ZHU RONG-RONG

193 PARKERVILLE ROAD, SOUTHBOROUGH, MA 01772, U.S.A.

4. SHEN JIANWEI

12549 W. MEADOW CIRCLE, LAKE BLUFF, IL 60044 U.S.A.

5. HARRIS MARIA C.

55 TROWBRIDGE LANE, SHREWSBURY, MA 01545 U.S.A.

6. BELANGER EILEEN

520 OLIVIA DRIVE, NORTHBRIDGE, MA 01534 U.S.A.

7. MURTAZA ANWAR

30 TREETOP PARK, WESTBOROUGH, MA 01581 U.S.A.

8. TARCSA EDIT

1 ROBIN CIRCLE, WESTBOROUGH, MA 01581 U.S.A.

9. STINE WILLIAM B.

18 QUAIL HOLLOW DRIVE, SHREWSBURY, MA 01545 U.S.A.

10. HSIEH CHUNG-MIND

22 ODE FIELD ROAD, NEWTON, MA 02459 U.S.A.