Prostaglandin Endoperoxide H Synthase Biosynthesis Inhibitors

Abstract: The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important 'housekeeping' enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectively of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).

Patent Information

Application #

Filing Date

23 April 2001

Publication Number

37/2007

Publication Type

INA

Invention Field

PHARMACEUTICALS

Status

Email

Parent Application

Applicants

ABBOTT LABORATORIES

CHAD 0377/AP6D-2 100 Abbott Park Road Abbott Park, IL 60064-6050,

Inventors

1. BLACK, Lawrence, A.

1173 Tamarack Lane Libertyville, IL 60048,

2. BASHA, Anwer

41 Heron Road Lake Forest, IL 60045

3. KOLASA, Teodozyj

118 Walden Lake Villa, IL 60046

4. KORT, Michael, E

507 N. Green Avenue Lake Bluff, IL 60044

5. LIU, Huaqing

2230 Apple Hill Court S Buffalo Grove, IL 60089

6. MCCARTY, Catherine, M.

430 Park Avenue Highland Park, IL 60035

7. PATEL, Meena, V.

605 W. Madison Street Chicago, IL 60661

8. ROHDE, Jeffrey, J.

1621 Ridge Avenue Evanston, IL 60201

9. COGHLAN, Michael, J.

307 Fairfax Lane Grayslake, IL 60030

10. STEWART, Andrew, O.

1289 Thornbury Lane Libertyville, IL 60048

Specification

Documents

Application Documents

#	Name	Date
1	IN-PCT-2001-00450-MUM-FORM 19 (17-05-2004).pdf	2004-05-17
2	in-pct-2001-00450-mum-form 1(17-5-2004).pdf	2018-08-08
3	in-pct-2001-00450-mum-correspondence(ipo)-(22-4-2010).pdf	2018-08-08
4	in-pct-2001-00450-mum-correspondence(10-5-2004).pdf	2018-08-08
5	abstract1.jpg	2018-08-08