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Pyridazinyl Thiazolecarboxamide Compound
Abstract: Provided is a compound that is useful as an active ingredient of a medicinal composition for treating cancer related to immunocyte activation or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy. The present inventors studied compounds being useful as an active ingredient of a medicinal composition for treating cancer related to immunocyte activation or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy and confirmed that a pyridazinyl thiazolecarboxamide compound has an effect of inhibiting DGK? (DGKzeta) to thereby complete the present invention. The pyridazinyl thiazolecarboxamide compound of the present invention has an effect of inhibiting DGK? and is usable as a therapeutic agent for cancer related to immunocyte activation or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
12 July 2022
Publication Number
29/2022
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
patent@depenning.com
Parent Application
Patent Number
Legal Status
Grant Date
2024-09-25
Renewal Date
Applicants
ASTELLAS PHARMA INC.
5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo
1038411
KOTOBUKI PHARMACEUTICAL CO., LTD.
6351, Oaza-Sakaki, Sakaki-machi, Hanishina-gun, Nagano
3890697
Inventors
1. WATANABE, Hideyuki
c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo
1038411
2. SEKI, Yohei
c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo
1038411
3. OKUYAMA, Keiichiro
c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo
1038411
4. KUROSAWA, Kazuo
c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo
1038411
5. IKEDA, Osamu
c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo
1038411
6. TOMIYAMA, Hiroshi
c/o Kotobuki Pharmaceutical Co., Ltd., 198, Aza-Higashikawahara, Oaza-Kamigomyo, Sakaki-machi, Hanishina-gun, Nagano
3890697
7. IWAI, Yoshinori
c/o Kotobuki Pharmaceutical Co., Ltd., 198, Aza-Higashikawahara, Oaza-Kamigomyo, Sakaki-machi, Hanishina-gun, Nagano
3890697
8. NAKAMURA, Akihiko
c/o Kotobuki Pharmaceutical Co., Ltd., 198, Aza-Higashikawahara, Oaza-Kamigomyo, Sakaki-machi, Hanishina-gun, Nagano
3890697
9. MIYASAKA, Kozo
c/o Kotobuki Pharmaceutical Co., Ltd., 198, Aza-Higashikawahara, Oaza-Kamigomyo, Sakaki-machi, Hanishina-gun, Nagano
3890697
Specification
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202247039978-IntimationOfGrant25-09-2024.pdf | 2024-09-25 |
| 1 | 202247039978.pdf | 2022-07-12 |
| 2 | 202247039978-PatentCertificate25-09-2024.pdf | 2024-09-25 |
| 2 | 202247039978-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [12-07-2022(online)].pdf | 2022-07-12 |
| 3 | 202247039978-STATEMENT OF UNDERTAKING (FORM 3) [12-07-2022(online)].pdf | 2022-07-12 |
| 3 | 202247039978-2. Marked Copy under Rule 14(2) [11-09-2024(online)].pdf | 2024-09-11 |
| 4 | 202247039978-PROOF OF RIGHT [12-07-2022(online)].pdf | 2022-07-12 |
| 4 | 202247039978-Annexure [11-09-2024(online)].pdf | 2024-09-11 |
| 5 | 202247039978-Retyped Pages under Rule 14(1) [11-09-2024(online)].pdf | 2024-09-11 |
| 5 | 202247039978-PRIORITY DOCUMENTS [12-07-2022(online)].pdf | 2022-07-12 |
| 6 | 202247039978-Written submissions and relevant documents [11-09-2024(online)].pdf | 2024-09-11 |
| 6 | 202247039978-FORM 1 [12-07-2022(online)].pdf | 2022-07-12 |
| 7 | 202247039978-DECLARATION OF INVENTORSHIP (FORM 5) [12-07-2022(online)].pdf | 2022-07-12 |
| 7 | 202247039978-Correspondence to notify the Controller [23-08-2024(online)].pdf | 2024-08-23 |
| 8 | 202247039978-FORM-26 [23-08-2024(online)].pdf | 2024-08-23 |
| 8 | 202247039978-COMPLETE SPECIFICATION [12-07-2022(online)].pdf | 2022-07-12 |
| 9 | 202247039978-RELEVANT DOCUMENTS [26-07-2022(online)].pdf | 2022-07-26 |
| 9 | 202247039978-US(14)-HearingNotice-(HearingDate-29-08-2024).pdf | 2024-08-08 |
| 10 | 202247039978-CLAIMS [08-07-2024(online)].pdf | 2024-07-08 |
| 10 | 202247039978-MARKED COPIES OF AMENDEMENTS [26-07-2022(online)].pdf | 2022-07-26 |
| 11 | 202247039978-FER_SER_REPLY [08-07-2024(online)].pdf | 2024-07-08 |
| 11 | 202247039978-FORM 13 [26-07-2022(online)].pdf | 2022-07-26 |
| 12 | 202247039978-Annexure [26-07-2022(online)].pdf | 2022-07-26 |
| 12 | 202247039978-FORM-26 [08-07-2024(online)].pdf | 2024-07-08 |
| 13 | 202247039978-AMMENDED DOCUMENTS [26-07-2022(online)].pdf | 2022-07-26 |
| 13 | 202247039978-OTHERS [08-07-2024(online)].pdf | 2024-07-08 |
| 14 | 202247039978-FORM-26 [07-10-2022(online)].pdf | 2022-10-07 |
| 14 | 202247039978-PETITION UNDER RULE 137 [08-07-2024(online)].pdf | 2024-07-08 |
| 15 | 202247039978-FORM-26 [13-10-2022(online)].pdf | 2022-10-13 |
| 15 | 202247039978-Information under section 8(2) [10-04-2024(online)].pdf | 2024-04-10 |
| 16 | 202247039978-FORM 3 [28-12-2022(online)].pdf | 2022-12-28 |
| 16 | 202247039978-Response to office action [10-04-2024(online)].pdf | 2024-04-10 |
| 17 | 202247039978-FORM 3 [30-01-2024(online)].pdf | 2024-01-30 |
| 17 | 202247039978-Correspondence_Form 1 And Form 26_18-01-2023.pdf | 2023-01-18 |
| 18 | 202247039978-FER.pdf | 2024-01-16 |
| 18 | 202247039978-RELEVANT DOCUMENTS [22-08-2023(online)].pdf | 2023-08-22 |
| 19 | 202247039978-AMMENDED DOCUMENTS [22-08-2023(online)].pdf | 2023-08-22 |
| 19 | 202247039978-MARKED COPIES OF AMENDEMENTS [22-08-2023(online)].pdf | 2023-08-22 |
| 20 | 202247039978-Annexure [22-08-2023(online)].pdf | 2023-08-22 |
| 20 | 202247039978-FORM 18 [22-08-2023(online)].pdf | 2023-08-22 |
| 21 | 202247039978-FORM 13 [22-08-2023(online)].pdf | 2023-08-22 |
| 22 | 202247039978-Annexure [22-08-2023(online)].pdf | 2023-08-22 |
| 22 | 202247039978-FORM 18 [22-08-2023(online)].pdf | 2023-08-22 |
| 23 | 202247039978-AMMENDED DOCUMENTS [22-08-2023(online)].pdf | 2023-08-22 |
| 23 | 202247039978-MARKED COPIES OF AMENDEMENTS [22-08-2023(online)].pdf | 2023-08-22 |
| 24 | 202247039978-RELEVANT DOCUMENTS [22-08-2023(online)].pdf | 2023-08-22 |
| 24 | 202247039978-FER.pdf | 2024-01-16 |
| 25 | 202247039978-FORM 3 [30-01-2024(online)].pdf | 2024-01-30 |
| 25 | 202247039978-Correspondence_Form 1 And Form 26_18-01-2023.pdf | 2023-01-18 |
| 26 | 202247039978-FORM 3 [28-12-2022(online)].pdf | 2022-12-28 |
| 26 | 202247039978-Response to office action [10-04-2024(online)].pdf | 2024-04-10 |
| 27 | 202247039978-FORM-26 [13-10-2022(online)].pdf | 2022-10-13 |
| 27 | 202247039978-Information under section 8(2) [10-04-2024(online)].pdf | 2024-04-10 |
| 28 | 202247039978-FORM-26 [07-10-2022(online)].pdf | 2022-10-07 |
| 28 | 202247039978-PETITION UNDER RULE 137 [08-07-2024(online)].pdf | 2024-07-08 |
| 29 | 202247039978-AMMENDED DOCUMENTS [26-07-2022(online)].pdf | 2022-07-26 |
| 29 | 202247039978-OTHERS [08-07-2024(online)].pdf | 2024-07-08 |
| 30 | 202247039978-Annexure [26-07-2022(online)].pdf | 2022-07-26 |
| 30 | 202247039978-FORM-26 [08-07-2024(online)].pdf | 2024-07-08 |
| 31 | 202247039978-FER_SER_REPLY [08-07-2024(online)].pdf | 2024-07-08 |
| 31 | 202247039978-FORM 13 [26-07-2022(online)].pdf | 2022-07-26 |
| 32 | 202247039978-CLAIMS [08-07-2024(online)].pdf | 2024-07-08 |
| 32 | 202247039978-MARKED COPIES OF AMENDEMENTS [26-07-2022(online)].pdf | 2022-07-26 |
| 33 | 202247039978-RELEVANT DOCUMENTS [26-07-2022(online)].pdf | 2022-07-26 |
| 33 | 202247039978-US(14)-HearingNotice-(HearingDate-29-08-2024).pdf | 2024-08-08 |
| 34 | 202247039978-COMPLETE SPECIFICATION [12-07-2022(online)].pdf | 2022-07-12 |
| 34 | 202247039978-FORM-26 [23-08-2024(online)].pdf | 2024-08-23 |
| 35 | 202247039978-Correspondence to notify the Controller [23-08-2024(online)].pdf | 2024-08-23 |
| 35 | 202247039978-DECLARATION OF INVENTORSHIP (FORM 5) [12-07-2022(online)].pdf | 2022-07-12 |
| 36 | 202247039978-Written submissions and relevant documents [11-09-2024(online)].pdf | 2024-09-11 |
| 36 | 202247039978-FORM 1 [12-07-2022(online)].pdf | 2022-07-12 |
| 37 | 202247039978-Retyped Pages under Rule 14(1) [11-09-2024(online)].pdf | 2024-09-11 |
| 37 | 202247039978-PRIORITY DOCUMENTS [12-07-2022(online)].pdf | 2022-07-12 |
| 38 | 202247039978-PROOF OF RIGHT [12-07-2022(online)].pdf | 2022-07-12 |
| 38 | 202247039978-Annexure [11-09-2024(online)].pdf | 2024-09-11 |
| 39 | 202247039978-STATEMENT OF UNDERTAKING (FORM 3) [12-07-2022(online)].pdf | 2022-07-12 |
| 39 | 202247039978-2. Marked Copy under Rule 14(2) [11-09-2024(online)].pdf | 2024-09-11 |
| 40 | 202247039978-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [12-07-2022(online)].pdf | 2022-07-12 |
| 40 | 202247039978-PatentCertificate25-09-2024.pdf | 2024-09-25 |
| 41 | 202247039978.pdf | 2022-07-12 |
| 41 | 202247039978-IntimationOfGrant25-09-2024.pdf | 2024-09-25 |
Search Strategy
| 1 | SearchHistoryE_14-01-2024.pdf |