Pyrrolidine Derivatives, Their Preparation And Their Use As Inhibitors

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Pyrrolidine Derivatives, Their Preparation And Their Use As Inhibitors Of Neuraminidases

Abstract: Enantiomerically enriched compounds having the absolute stereochemistry of the formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

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Notices, Deadlines & Correspondence

Patent Information

Application #

Filing Date

10 April 2002

Publication Number

37/2007

Publication Type

INA

Invention Field

PHARMACEUTICALS

Status

Parent Application

Applicants

ABBOTT LABORATORIES

Dept. 377, Bldg. AP6D-2, 100 Abbott Park Road, Abbott Park, IL 60064-6050

Inventors

1. MARING, Clarence, J

1228 Borders, Palatine, IL 60067

2. GIRANDA, Vincent, L

272 S. Fork Drive, Gurnee, IL 60031

3. KEMPF, Dale, J

256 Tyler Court, Libertyville, IL 60048

4. STOLL, Vincent, S.

218 E. Winchester Road, Libertyville, IL 60048

5. SUN, Minghua

1733 Cedar Glen Drive, Libertyville, IL 60048

6. ZHAO, Chen

1417 Castleton Road, Libertyville, IL 60048

7. GU, Yu, Gui

1221 Virginia Ave., Libertyville, IL 60048

8. HANESSIAN, Stephen

65 Gables Court, Beaconsfield, Québec H9W 5H3

9. WANG, Gary, T

8602 Osceola Avenue, Niles, IL 60714

10. KRUEGER, Allan, C

7260 Presidential Drive, Gurnee, IL 60031

11. CHEN, Hui-Ju

4 Crows Nest Court, Grayslake, IL 60030

12. CHEN, Yuanwei

15 Blueridge, North Haven, CT 06473

13. DEGOEY, David, A

6501 43rd Avenue, Kenosha, WI 53142

14. FLOSI, William, J

1461 Wicke Avenue, Des Plaines, IL 60018

15. GRAMPOVNIK, David, J

2500 Walnut Street, Waukegan, IL 60087

16. KATI, Warren, M

152 Knobb Hill Lane, Gurnee, IL 60031

17. KENNEDY, April, L

4530 Martin Drive, Boulder, CO 80303

18. KLEIN, Larry, L

26 Washington Road, Lake Forest, IL 60045

19. LIN, Zhen

1138 Tyme Court, Gurnee, IL 60031

20. MADIGAN, Darold, L

908 Wisconsin, Elk Grove Village, IL 60007

21. MCDANIEL, Keith, F

26029 W. Laurel Ct., Wauconda, IL 60084

22. MUCHMORE, Steven, W

1168 Tamarack Lane, Libertyville, IL 60048

23. SHAM, Hing, L

1666 N. St. Andrews Dr., Vernon Hills, IL 60061

24. STEWART, Kent, D

4715 King's Way North, Gurnee, IL 60031

25. TU, Noah, P

1496 Vineyard Drive, Gurnee, IL 60031

26. WAGENAAR, Frank, L

586 Lexington Sq. E., Gurnee, IL 60031

27. WANG, Sheldon

14066 Honey Tree Drive, Carmel, IN 46032

28. WIEDEMAN, Paul, E

1040 Sheridan Avenue, Deerfield, IL 60015

29. XU, Yibo

17 Cedar Vale Drive, New Milford, CT 06776

30. YEUNG, Ming, C

34422 N. Tangueray Drive, Grayslake, IL 60030

31. BAYRAKDARIAN, Malken

228 Darwin, 407, Ile-des-Souers, Verdun, Québec H3E 1C6

32. LUO, Xuehong

3540 Cote Ste-Catherine, Apt. 4, Montreal, Québec H3T 1C9