Rna Molecule, Chimeric Na Molecule, Double Stranded Rna Molecule, And

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Rna Molecule, Chimeric Na Molecule, Double Stranded Rna Molecule, And Double Stranded Chimeric Na Molecule

Abstract: The purpose of the present invention is to provide a novel RNA molecule. An RNA molecule for RNA interference for which the target gene is a mutant allele that has a point mutation. The RNA molecule (1) has a base sequence that is complementary to a coding region of the mutant allele, and (2) counting from the base that is furthest to the 5' side of the base sequence that is complementary to the mutant allele, (2-1) the 5th or 6th base is mismatched with the base of the mutant allele, (2-2) the 10th or 11th base corresponds to the location of the point mutation, and (2-3) at the 6th-8th bases or the 7th and 8th bases, the pentose is modified with OCH3 or the like at the 2' position. The ribonucleotides of the RNA molecule may be replaced with deoxyribonucleotides or the like, and the RNA molecule may form a double-stranded RNA with a complementary strand.

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Notices, Deadlines & Correspondence

Patent Information

Application #

Filing Date

11 August 2023

Publication Number

48/2023

Publication Type

INA

Invention Field

BIOTECHNOLOGY

Status

Email

Parent Application

Applicants

THE UNIVERSITY OF TOKYO

3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654

Inventors

1. UI-TEI, Kumiko

c/o THE UNIVERSITY OF TOKYO, 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654

2. KOBAYASHI, Yoshiaki

c/o THE UNIVERSITY OF TOKYO, 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654

3. SATO, Atsushi

c/o THE UNIVERSITY OF TOKYO, 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654

4. ASANO, Yoshimasa

c/o THE UNIVERSITY OF TOKYO, 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654

5. SUZUKI, Yuria

c/o THE UNIVERSITY OF TOKYO, 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654

6. LEDEY, Naomi

c/o THE UNIVERSITY OF TOKYO, 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654

7. SAIGO, Kaoru

4-31-7 Izumi, Suginami-ku, Tokyo 1680063

8. NATORI, Yukikazu

4-10-1-E1706 Minatomirai, Nishi-ku, Yokohama-shi, Kanagawa 2200012

Specification

Documents

Application Documents

#	Name	Date
1	202317053942-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [11-08-2023(online)].pdf	2023-08-11
2	202317053942-STATEMENT OF UNDERTAKING (FORM 3) [11-08-2023(online)].pdf	2023-08-11
3	202317053942-Sequence Listing in txt [11-08-2023(online)].txt	2023-08-11
4	202317053942-Sequence Listing in PDF [11-08-2023(online)].pdf	2023-08-11
5	202317053942-REQUEST FOR EXAMINATION (FORM-18) [11-08-2023(online)].pdf	2023-08-11
6	202317053942-PRIORITY DOCUMENTS [11-08-2023(online)].pdf	2023-08-11
7	202317053942-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [11-08-2023(online)].pdf	2023-08-11
8	202317053942-FORM FOR SMALL ENTITY(FORM-28) [11-08-2023(online)].pdf	2023-08-11
9	202317053942-FORM 18 [11-08-2023(online)].pdf	2023-08-11
10	202317053942-FORM 1 [11-08-2023(online)].pdf	2023-08-11
11	202317053942-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [11-08-2023(online)].pdf	2023-08-11
12	202317053942-DRAWINGS [11-08-2023(online)].pdf	2023-08-11
13	202317053942-DECLARATION OF INVENTORSHIP (FORM 5) [11-08-2023(online)].pdf	2023-08-11
14	202317053942-COMPLETE SPECIFICATION [11-08-2023(online)].pdf	2023-08-11
15	202317053942-Proof of Right [27-10-2023(online)].pdf	2023-10-27
16	202317053942-FORM-26 [27-10-2023(online)].pdf	2023-10-27
17	202317053942-FORM 3 [31-01-2024(online)].pdf	2024-01-31