Rna Trans Splicing Molecule

Abstract: This invention relates to an RNA trans- splicing molecule (RTM) that targets human endogenous retrovirus (HERV) pre-mRNA. The RTM comprises (i) a binding region specific for a HERV pre-mRNA, (ii) a trans- splicing splice domain and (ill) a coding sequence for a suicide protein. The binding region of the RTM binds to HERV pre-mRNA in a cell, such that the coding sequence is trans- spliced through the trans- splicing domain with the HERV pre-mRNA, resulting in a chimeric mRNA causing the suicide protein to be expressed in the cell. RTMs of the invention may be useful in selectively killing cells that express HERV genes, for example cancer cells. RTMs, encoding nucleic acids, methods of treatment and associated methods and uses are provided.

Patent Information

Application #

Filing Date

01 September 2023

Publication Number

40/2023

Publication Type

INA

Invention Field

BIOTECHNOLOGY

Status

Email

Parent Application

Applicants

CAMBRIDGE ENTERPRISE LIMITED

The Old Schools Trinity Lane Cambridge Cambridgeshire CB2 1TN

Inventors

1. INGEMARSDOTTER, Carin

c/o Spliceor Ltd Salisbury House Station Road Cambridge Cambridgeshire CB1 2LA

2. LEVER, Andrew

c/o Spliceor Ltd Salisbury House Station Road Cambridge Cambridgeshire CB1 2LA

Specification

Documents

Application Documents

#	Name	Date
1	202347058808-STATEMENT OF UNDERTAKING (FORM 3) [01-09-2023(online)].pdf	2023-09-01
2	202347058808-Sequence Listing in txt [01-09-2023(online)].txt	2023-09-01
3	202347058808-Sequence Listing in PDF [01-09-2023(online)].pdf	2023-09-01
4	202347058808-PRIORITY DOCUMENTS [01-09-2023(online)].pdf	2023-09-01
5	202347058808-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [01-09-2023(online)].pdf	2023-09-01
6	202347058808-FORM 1 [01-09-2023(online)].pdf	2023-09-01
7	202347058808-DRAWINGS [01-09-2023(online)].pdf	2023-09-01
8	202347058808-DECLARATION OF INVENTORSHIP (FORM 5) [01-09-2023(online)].pdf	2023-09-01
9	202347058808-COMPLETE SPECIFICATION [01-09-2023(online)].pdf	2023-09-01
10	202347058808-Proof of Right [15-11-2023(online)].pdf	2023-11-15
11	202347058808-FORM-26 [15-11-2023(online)].pdf	2023-11-15
12	202347058808-FORM 3 [18-01-2024(online)].pdf	2024-01-18
13	202347058808-FORM 18 [29-01-2025(online)].pdf	2025-01-29