FORM 2
THE PATENTS ACT 1970
(39 of 1970)
&
The Patents Rules  2003
COMPLETE SPECIFICATION
(See section 10 and rule 13)

1. SALTS OF SAXAGLIPTIN WITH ORGANIC ACIDS

2.

1. (A) APOTEX PHARMACHEM INDIA PVT. LTD.
(B) Indian
(C) Plot No. 1A  Bommasandra Industrial Area  4th Phase Jigani Link Road 
Bommasandra  BANGALORE - 560 099  INDIA

The following specification particularly describes the invention and the manner in which it is to be performed.

TECHNICAL FIELD
The invention relates to salts of Saxagliptin with organic acids (HA) represented by formula (I). The present invention also relates to the methods of making the salts of Saxagliptin with organic acids.

BACKGROUND
Saxagliptin [(1S 3S 5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)
acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile] and its hydrochloride salt are orally active reversible dipeptidyl peptidase-4 (DPP4) inhibitors  which are used as therapeutic agents for the treatment of type-2-diabetes mellitus  obesity  or related diseases. It is disclosed in example 60 of US 6 395 767.
PCT application WO 2001068603 A2 dislcoses Saxagliptin in the form of its trifluoroacetate salt  as described in Example 60.
The processes for the preparation of Saxagliptin benzoate salt (scheme VII  Example 41)  Saxagliptin free base and free base monohydrate (Example 42)  and Saxagliptin hydrochloride (scheme VIIB  Example 42) are disclosed in the PCT application WO 2004052850 A2.
WO 2008131149 A2 discloses Saxagliptin free base  specific acid addition salts of Saxagliptin such as hydrochloride  hydrobromide  hydroiodide  ammonium sulfate  nitrate  benzoate  tartrate  fumarate and trifluoroacetate salts  and certain polymorphs  and hydrates thereof.
Methods of preparation of Saxagliptin hydrochloride are described in US 7 214 702 B2 and in Organic Process Research & Development 2009  13(6)  1169-1176.
PCT application WO 2010115974 A1 describes certain polymorphic forms of Saxagliptin hydrochloride.
CN 102086172 A discloses mesylate  maleate  malate  succinate and citrate salts of Saxagliptin.
PCT application WO 2012017028 A1 describes the phosphoric acid salt of Saxagliptin and its polymorphic forms.
PCT application WO 2012017029 A1 discloses crystalline forms of Saxagliptin salts with organic diacids such as form A of Saxagliptin maleate  form B of Saxagliptin L-malate  and form C of Saxagliptin succinate.

SUMMARY
The invention is based  at least in part  on salts of Saxagliptin with organic acids (HA) represented by formula I. The present invention is also based  at least in part  on methods of making the salts of Saxagliptin with organic acids. The salts of the present invention may exhibit good filtration characteristics and may be isolated with high purity.

Provided are the compounds of formula Ia and Ib:


The nicotinate salt (compound of formula Ia) and the salicylate (compound of formula Ib)  are suitable for use as intermediates in the isolation of Saxagliptin in high purity and to prepare other pharmaceutically acceptable salts such as the hydrochloride. They may also be useful in Saxagliptin compositions.
In illustrative embodiments  there is provided  a salt of Saxagliptin of formula (I): (I) wherein HA is or .
In illustrative embodiments  there is provided a salt of Saxagliptin described herein wherein the salt is crystalline.
In illustrative embodiments  there is provided a sSaxagliptin nicotinate of formula (Ia): .
In illustrative embodiments  there is provided a Saxagliptin nicotinate (Ia) described herein in a crystalline monohydrate form.
In illustrative embodiments  there is provided a Saxagliptin nicotinate (Ia) described herein characterized by a XRPD diffractogram having peaks  expressed in degrees 2 theta  at approximately 7.3  10.9  16.3  19.2  and 20.6.
In illustrative embodiments  there is provided a Saxagliptin nicotinate (Ia) described herein characterized by a XRPD diffractogram substantially similar to the XRPD diffractogram in Figure 1.
In illustrative embodiments  there is provided a Saxagliptin nicotinate (Ia) described herein characterized by a DSC thermogram having two endothermic peaks with peak maxima at approximately 88°C and approximately 235°C and two exothermic peaks with peak maxima at approximately 140°C and approximately 160°C.
In illustrative embodiments  there is provided a Saxagliptin nicotinate (Ia) described herein characterized by a DSC thermogram substantially similar to the DSC thermogram in Figure 3.
In illustrative embodiments  there is provided a Saxagliptin nicotinate (Ia) described herein characterized by an IR spectrum having one or more adsorption peaks  expressed in cm-1  at approximately 3336  3046  2134 and 1647.
In illustrative embodiments  there is provided a Saxagliptin nicotinate (Ia) described herein characterized by an IR spectrum substantially similar to the IR spectrum in Figure 5.
In illustrative embodiments  there is provided a Saxagliptin salicylate of formula (Ib): .
In illustrative embodiments  there is provided a Saxagliptin salicylate (Ib) described herein in an anhydrous crystalline form.
In illustrative embodiments  there is provided a Saxagliptin salicylate (Ib) described herein characterized by a XRPD diffractogram having peaks  expressed in degrees 2 theta  at approximately 6.7  8.4  13.4  15.1  17.5  and 21.1.
In illustrative embodiments  there is provided a Saxagliptin salicylate (Ib) described herein characterized by a XRPD diffractogram substantially similar to the XRPD diffractogram in Figure 2.
In illustrative embodiments  there is provided a Saxagliptin salicylate (Ib) described herein characterized by a DSC thermogram having an exothermic peak with a peak maximum at approximately 210°C and an endothermic peak with a peak maximum at approximately 263°C.
In illustrative embodiments  there is provided a Saxagliptin salicylate (Ib) described herein characterized by a DSC thermogram substantially similar to the DSC thermogram in Figure 4.
In illustrative embodiments  there is provided a Saxagliptin salicylate (Ib) described herein characterized by an IR spectrum having one or more adsorption peaks  expressed in cm-1  at approximately 3584  3455  3041.8  2112  1669 and 1630.
In illustrative embodiments  there is provided a Saxagliptin salicylate (Ib) described herein characterized by an IR spectrum substantially similar to the IR spectrum in Figure 6.
In illustrative embodiments  there is provided a process for the preparation of salts of Saxagliptin of formula I: (I) wherein HA is or   the process comprising: (a) treating  at a temperature of about 40oC to about 65oC  (S)-N-Boc-3-hydroxyadamantylglycine-L-cis-4 5-methanoprolinenitrile with either: (i) a mineral acid in water or (ii) a mixture of water and an alcoholic solvent  thereby forming a solution; (b) adding a water-immiscible solvent to the solution  thereby forming a bi-phasic solution; (c) basifying the bi-phasic solution by adjusting the pH to about 9 to about 9.5  thereby forming a basified bi-phasic solution; (d) separating an organic phase from the basified bi-phasic solution; (e) treating the organic phase with an organic acid  thereby forming a treated organic phase; and (f) isolating the salt of Saxagliptin from the treated organic phase.
In illustrative embodiments  there is provided a process described herein wherein the mineral acid is hydrochloric acid.
In illustrative embodiments  there is provided a process described herein wherein the alcoholic solvent is a C1-C3 alkanol selected from the group consisting of methanol  ethanol  and isopropanol.
In illustrative embodiments  there is provided a process described herein wherein the water-immiscible solvent is dichloromethane or ethyl acetate.
In illustrative embodiments  there is provided a process described herein wherein the organic acid is selected from the group consisting of nicotinic acid and salicylic acid.
Other aspects and features of the present invention will become apparent to those ordinarily skilled in the art upon review of the following description of specific embodiments of the invention in conjunction with the accompanying figures.

BRIEF DESCRIPTION OF THE DRAWINGS
In drawings which illustrate embodiments of the invention 
Figure 1: is a X-ray powder diffraction pattern (XRPD) of Saxagliptin nicotinate as per Example 1.
Figure 2: is a X-ray powder diffraction pattern of Saxagliptin salicylate as per Example 3.
Figure 3: is a DSC of Saxagliptin nicotinate as per Example 1.
Figure 4: is a DSC of Saxagliptin salicylate as per Example 3.
Figure 5: is an IR absorption spectrum of Saxagliptin nicotinate as per Example 1.
Figure 6: is an IR absorption spectrum of Saxagliptin salicylate as per Example 3.

DETAILED DESCRIPTION
When used in reference to a spectrum and/or data presented in a graph  the term “substantially” should be interpreted as encompassing a diffractogram within acceptable boundaries of experimentation.
When used in reference to a peak in the XRPD diffractogram  the term “approximately” generally means that the peak is within plus or minus 0.2 degrees 2 theta of the quoted value.
When used in reference to a peak in the FTIR spectrum  the term “approximately” generally means that the peak is within plus or minus 5 cm-1 of the quoted value.
When used in reference to a peak in the DSC thermogram  the term “approximately” generally means that the peak is within plus or minus 2 degrees of the quoted value.
As used herein when referring to a spectrum and/or to data presented in a graph  the term "peak" refers to a feature that one skilled in the art would recognize as not attributable to background noise.
Depending on the nature of the methodology applied and the scale selected to display results obtained from X-ray diffraction analysis  the peak intensities of peaks obtained may vary quite dramatically. For example  it is possible to obtain a relative peak intensity of 0.01% when analyzing one sample of a substance  but another sample of the same substance may show a much different relative intensity for a peak at the same position. This may be due  in part  to the preferred orientation of the sample and its deviation from the ideal random sample orientation  sample preparation and the methodology applied
The present invention encompasses the salts isolated in pure form or when admixed with other materials  for example other isomers and/or polymorphic forms and/or salt forms or any other material.
Hydrates have some variability in the exact molar ratio of their components depending on a variety of conditions understood to a person of skill in the art. For example  a molar ratio of components within a solvate provides a person of skill in the art information as to the general relative quantities of the components of the solvate and in many cases the molar ratio may vary by about plus or minus 20% from a stated range. For example  a molar ratio of 1:1 is understood to include the ratio 1:0.8 as well as 1:1.2 as well as all of the individual ratios in between.
Saxagliptin in the form of the salts with either nicotinic acid or salicylic acid is easier to isolate in high purity than the free base. These salt-forms reduce the propensity of the molecule to undergo decomposition. Saxagliptin is known to undergo intramolecular cyclization to produce the cyclic amidine impurity (compound of formula A) (Organic Process Research & Development 2009  13  1169–1176 (page 1173) and WO 2011/140328 A1 (page 29)) during crystallization and upon storage.

In one embodiment  the present invention provides a salt of Saxagliptin represented by formula (I).

In another embodiment  there is provided a Saxagliptin nicotinate salt of formula (Ia) 

Saxagliptin nicotinate of formula (Ia) has a crystalline nature and is found to be a monohydrate as indicated by a water content of about 4.3% as measured by the Karl-Fischer method.
An illustrative XRPD diffractogram of Saxagliptin nicotinate of formula (Ia) acquired according to the conditions given in Example 4 is shown in Figure 1. According to Figure 1  the Saxagliptin nicotinate of formula (Ia) may have a reflection (“peak”) at any one or more of the following values expressed in degrees 2? at approximately 7.3  10.9  16.3  19.2  and 20.6.
An illustrative FTIR spectrum of the Saxagliptin nicotinate of formula (Ia) acquired according to the conditions given in Example 5 is shown in Figure 5. According to Figure 5  the Saxagliptin nicotinate of formula (Ia) may have an absorption band (“peak”) at any one or more of the following values expressed in cm-1 of approximately 3336  3046  2134 and 1647.
An illustrative DSC thermogram of Saxagliptin nicotinate of formula (Ia) acquired according to the conditions given in Example 6 is shown in Figure 3. The DSC thermogram shown in Figure 3 may be illustrative of the type of results obtained when analysing Saxagliptin nicotinate of formula (Ia) by DSC. The DSC thermogram may be further characterized by two endothermic peaks with peak maxima at approximately 88°C and approximately 235°C and two exothermic peaks with peak maxima at approximately 140°C and approximately 160°C.
In another embodiment  there is provided a Saxagliptin salicylate salt of formula (Ib) 

Saxagliptin salicylate of formula (Ib) has a crystalline nature and is essentially anhydrous as indicated by a water content of not more than approximately 0.5% as measured by the Karl-Fischer method.
An illustrative XRPD diffractogram of Saxagliptin salicylate salt of formula (Ib) acquired according to the conditions given in Example 4 is shown in Figure 2. According to Figure 2  the Saxagliptin salicylate salt of formula (Ib) may have a reflection (“peak”) at any one or more of the following values expressed in degrees 2 theta at approximately 6.7  8.4  13.4  15.1  17.5  and 21.1.
An illustrative FT spectrum of the Saxagliptin salicylate salt of formula (Ib) acquired according to the conditions given in Example 5 is shown in Figure 6. According to Figure 6  the Saxagliptin salicylate salt of formula (Ib) may have an absorption band (“peak”) at any one or more of the following values expressed in cm-1 of approximately 3584  3455  3041.8  2112  1669 and 1630.
An illustrative DSC thermogram of Saxagliptin salicylate salt of formula (Ib) acquired according to the conditions given in Example 6 is shown in Figure 4. The DSC thermogram shown in Figure 4 may be illustrative of the type of results obtained when analysing Saxagliptin salicylate salt of formula (Ib) by DSC. The DSC thermogram may be further characterized by an exothermic peak with a peak maximum at approximately 210°C and an endothermic peak with a peak maximum at approximately 263°C.
In an embodiment of the present invention  there is provided a process for the preparation of salts of Saxagliptin of formula (I):

comprising:
a) treating(S)-N-Boc-3-hydroxyadamantylglycine-L-cis-4 5-methanoprolinenitrile (II) with a mineral acid in water or a mixture of water and an alcoholic solvent at a temperature of about 40°C to about 65°C 
b) adding a water-immiscible solvent 
c) basifying the bi-phasic solution containing Saxagliptin free base by adjusting the pH to 9 to 9.5 
d) separating the organic phase 
e) treating the organic phase with an organic acid  and
f) isolating the organic acid salt of Saxagliptin.
The mineral acid used in step (a) may be selected from the group consisting of HCl or H2SO4. In an embodiment  the mineral acid is HCl.
The alcoholic solvent may be selected from the group consisting of C1-C3 alkanols such as methanol  ethanol  and isopropanol. In an embodiment  the alcoholic solvent is isopropanol.
The water-immiscible solvent in step (b) may be dichloromethane or ethyl acetate.
The organic acids used for the preparation of salts of Saxagliptin are nicotinic acid and salicylic acid. The organic acid used is about 1 to 1.1 equivalents relative to Saxagilptin.
In illustrative embodiments of the present invention  the salts of the invention may be prepared by an exemplary process as set out in Scheme 1. Exemplary reagents and conditions for these reactions are disclosed herein.
Scheme 1

EXAMPLES
The following examples are illustrative of some of the embodiments of the invention described herein. These examples should not be considered to limit the spirit or scope of the invention in any way.

Example 1: Preparation of Saxagliptin nicotinate (Ia)
To a well-stirred mixture of 5g of (S)-N-Boc-3-hydroxyadamantylglycine-L-cis-4 5-methanoprolinenitrile (II) in water (5mL) was added isopropyl alcohol (5mL) at 30oC  followed by 1.4 equivalents of conc. HCl  and the reaction mixture was heated to 60-65oC. The reaction mass was maintained at this temperature for 1.5-2h. The reaction was monitored for completion by TLC. After completion of the reaction  the reaction mixture was diluted with water (10mL) and cooled to 20-30oC. To the clear solution  dichloromethane (30mL) was added and the mixture was stirred well at 20-30oC. 10N NaOH (1.2g) solution was added and the bi-layer pH was adjusted to 9-9.5 using 25% potassium carbonate solution (final pH 9.45) at 20-30oC. The reaction mass was saturated with sodium chloride (6.25g) and stirred well for 15-20min. The layers were separated and the aqueous layer was extracted with dichloromethane (30mL). To the combined dichloromethane layer  1.05 eq of nicotinic acid (1.56g) was added and the reaction mixture was stirred well at 20-30oC for 0.5 to 1h whereupon 1.5 eq of water was charged to the reaction mass and it was stirred for a further 3-5h at 20-30oC. The solid Saxagliptin nicotinate was filtered  washed with dichloromethane (10mL)  and dried. The damp material was dried in an oven at NMT 45oC under vacuum for 4-5h. (Yield: 69%; HPLC Purity = 99.39%)
1H NMR (CD3OD  300MHz) d (ppm): 0.85-0.87 (m  1H)  0.93-1.02 (q  1H  J=6Hz)  1.51-1.73 (m  12H)  1.80-1.94 (m  1H)  2.17-2.24 (m  3H)  2.36-2.50 (m  1H)  3.76-3.85 (m  1H)  4.17 (s  1H)  5.04-5.08 (dd  1H  J=9Hz  3Hz)  7.36-7.41 (m  1H)  8.19-8.26 (2t  1H  J=3Hz)  8.49-8.51 (dd  1H  J=6Hz  3Hz)  8.96-8.97 (m  1H).
13C NMR (CD3OD  75MHz) d (ppm): 14.4  19.2  31.4  31.5  31.5  36.0  38.2  38.2  39.3  41.0  44.8  44.9  46.7  46.9  60.1  68.7  120.5  124.8  133.4  138.9  151.1  151.7  168.3  171.3.
Moisture content (by Karl-Fischer method): 4.3%.

Example 2: Preparation of Saxagliptin nicotinate (Ia)
To a well-stirred mixture of 10g of (S)-N-Boc-3-hydroxyadamantylglycine-L-cis-4 5-methanoprolinenitrile (II) in 30 mL water  1.4eq of conc. HCl was added at NMT 30°C and the reaction mixture was heated to 60-65°C. The reaction mass was maintained at this temperature for 2-3h. After reaction completion (TLC)  the reaction mixture was diluted with 20mL water and cooled to 20-30°C. Dichloromethane (60mL) was added to the solution which was stirred well at 20-30°C. 10N NaOH solution was added and the bi-layer pH adjusted to 9-9.5 using 25% potassium carbonate solution (final pH 9.3) at 20-30°C. The reaction mass was saturated with 12.5g of sodium chloride and stirred well for 15-20min. The layers were separated and the aqueous layer extracted with 60mL of dichloromethane. To the combined dichloromethane layer  1.05eq of nicotinic acid (3.12g) was added and the reaction mixture was stirred at 20-30°C for 0.5 to 1h. 1.5 eq of water was charged to the reaction mass and stirred for 3-5h at 20-30oC. The solid Saxagliptin nicotinate was filtered and washed with 20mL of dichloromethane and suction dried. The damp material dried in oven at NMT 45°C under vacuum for 4-5hrs. (Yield: 80%; purity: HPLC purity = 99.51%).
The Saxagliptin nicotinate obtained in this example is substantially the same as the sample obtained in Example-1 above.

Example 3: Preparation of Saxagliptin salicylate (Ib)
To a well-stirred mixture of 5g of (S)-N-Boc-3-hydroxyadamantylglycine-L-cis-4 5-methanoprolinenitrile (II) in water (5mL) was added isopropyl alcohol (5mL) at 30oC  followed by 1.4 equivalents of conc. HCl and the reaction mixture was heated to 60-65oC. The reaction mixture was maintained at this temperature for 1.5-2h. After completion of the reaction (TLC)  the reaction mixture was diluted with water (10mL) and cooled to 20-30oC. Dichloromethane (25mL) was added to the solution which was stirred well at 20-30oC. 10N NaOH (1.2g) solution was added and the bi-layer pH was adjusted to 9-9.5 using 25% potassium carbonate solution at 20-30oC. The reaction mixture was saturated with sodium chloride (7.5g) and stirred well for 15-20min. The layers were separated and the aqueous layer was extracted with dichloromethane (30mL). To the combined dichloromethane layer  1.05 eq of salicylic acid was added and the reaction mixture was stirred well at 20-30oC for 2.5-3h. The solid Saxagliptin salicylate was filtered and washed with dichloromethane (20mL) and dried. (Yield: 77%; HPLC Purity = 99.20%)
1H NMR (DMSO-d6  300MHz) d (ppm): 0.72-0.75 (m  1H)  0.98-1.05 (q  1H  J=6Hz)  1.47-1.69 (m  12H)  1.81-1.89 (m  1H)  2.15-2.27 (m  3H)  2.35-2.45 (m  1H)  4.01-4.04 (m  1H)  4.23 (s  1H)  5.12-5.16 (dd  1H  J=9Hz  3Hz)  6.62-6.68 (m  2H)  7.16-7.22 (m  1H)  7.66-7.82 (dd  1H  J=9Hz  3Hz).
13C NMR (DMSO-d6  75MHz) d (ppm): 12.9  17.3  29.4  29.5  29.9  34.8  36.6  36.7  37.7  39.1  44.1  44.2  45.1  45.4  57.8  66.3  115.8  116.5  119.3  119.7  130.0  131.9  162.1  166.7  172.2.
Moisture content (by Karl-Fischer method): 0.13%.

Example 4: X-ray Powder Diffraction (XRPD) Analysis
The data were acquired on a PANanalytical X-pert Pro MPD diffractometer with fixed divergence slits and an X-Celerator RTMS detector. The diffractometer was configured in Bragg-Brentano geometry; data was collected over a 2? range of 5 to 35 using CuKa radiation at a power of 40mA and 45kV. CuKß radiation was removed using a divergent beam Nickel filter. A step size of 0.017 degrees was used. A step time of 20 seconds was used. Samples were rotated at 1Hz to reduce preferred orientation effects. The samples were prepared by the back-loading technique.

Example 5: FT-Infrared Spectroscopy Method
FT-IR spectroscopy was performed with a Perkin-Elmer FT-IR spectrometer. For the production of KBr compacts approximately 3mg of sample was powdered with 300mg of KBr. The spectra were recorded in transmission mode ranging from 4000 to 400cm-1.

Example 6: Differential Scanning Calorimetry (DSC) Analysis
The DSC thermograms were collected on a Mettler-Toledo 822e instrument. Samples (1 to 3mg) were weighed into a 40µL aluminum pan and were crimped closed with an aluminum lid. The samples were analyzed under a flow of nitrogen (ca. 50mL/min) at a scan rate of 10oC/minute  from 40 to 300oC.

Example 7: 1H Nuclear Magnetic Resonance Spectroscopy
The 1H NMR spectra were recorded on a Bruker 300MHz instrument. The sample (5-10 mg) was dissolved in deuterated solvent and the spectrum was recorded for 0-15 d value.

Example 8: 13C Nuclear Magnetic Resonance Spectroscopy
The 13C NMR spectra were recorded on a Bruker 300MHz instrument at a field of 75MHz. The sample (5-10 mg) was dissolved in deuterated solvent and the spectrum was recorded for 0-200 d value.

Although various embodiments of the invention are disclosed herein  many adaptations and modifications may be made within the scope of the invention in accordance with the common general knowledge of those skilled in this art. Such modifications include the substitution of known equivalents for any aspect of the invention in order to achieve the same result in substantially the same way. Numeric ranges are inclusive of the numbers defining the range. The word "comprising" is used herein as an open-ended term  substantially equivalent to the phrase "including  but not limited to"  and the word "comprises" has a corresponding meaning. As used herein  the singular forms "a"  "an" and "the" include plural referents unless the context clearly dictates otherwise. Thus  for example  reference to "a thing" includes more than one such thing. Citation of references herein is not an admission that such references are prior art to the present invention. Any priority document(s) are incorporated herein by reference as if each individual priority document were specifically and individually indicated to be incorporated by reference herein and as though fully set forth herein. The invention includes all embodiments and variations substantially as hereinbefore described and with reference to the examples and drawings.

We Claim:-

1. A salt of Saxagliptin of formula (I):

(I)
wherein HA is or .

2. The salt of claim 1 wherein the salt is crystalline.

3. Saxagliptin nicotinate of formula (Ia):
.

4. The Saxagliptin nicotinate (Ia) according to claim 3 in a crystalline monohydrate form.

5. The Saxagliptin nicotinate (Ia) according to claim 3 or 4 characterized by a XRPD diffractogram having peaks  expressed in degrees 2 theta  at approximately 7.3  10.9  16.3  19.2  and 20.6.

6. The Saxagliptin nicotinate (Ia) according to claim 3 or 4 characterized by a XRPD diffractogram substantially similar to the XRPD diffractogram in Figure 1.

7. The Saxagliptin nicotinate (Ia) according to any one of claims 3 to 6 characterized by a DSC thermogram having two endothermic peaks with peak maxima at approximately 88°C and approximately 235°C and two exothermic peaks with peak maxima at approximately 140°C and approximately 160°C.

8. The Saxagliptin nicotinate (Ia) according to any one of claims 3 to 6 characterized by a DSC thermogram substantially similar to the DSC thermogram in Figure 3.

9. The Saxagliptin nicotinate (Ia) according to any one of claims 3 to 8 characterized by an IR spectrum having one or more adsorption peaks  expressed in cm-1  at approximately 3336  3046  2134 and 1647.

10. The Saxagliptin nicotinate (Ia) according to any one of claims 3 to 8 characterized by an IR spectrum substantially similar to the IR spectrum in Figure 5.

11. Saxagliptin salicylate of formula (Ib):
.

12. The Saxagliptin salicylate (Ib) according to claim 11 in an anhydrous crystalline form.

13. The Saxagliptin salicylate (Ib) according to claim 10 or 11 characterized by a XRPD diffractogram having peaks  expressed in degrees 2 theta  at approximately 6.7  8.4  13.4  15.1  17.5  and 21.1.

14. The Saxagliptin salicylate (Ib) according to claim 10 or 11 characterized by a XRPD diffractogram substantially similar to the XRPD diffractogram in Figure 2.

15. The Saxagliptin salicylate (Ib) according to any one of claims 10 to 14 characterized by a DSC thermogram having an exothermic peak with a peak maximum at approximately 210°C and an endothermic peak with a peak maximum at approximately 263°C.

16. The Saxagliptin salicylate (Ib) according to any one of claims 10 to 14 characterized by a DSC thermogram substantially similar to the DSC thermogram in Figure 4.

17. The Saxagliptin salicylate (Ib) according to any one of claims 10 to 16 characterized by an IR spectrum having one or more adsorption peaks  expressed in cm-1  at approximately 3584  3455  3041.8  2112  1669 and 1630.

18. The Saxagliptin salicylate (Ib) according to any one of claims 10 to 16 characterized by an IR spectrum substantially similar to the IR spectrum in Figure 6.

19. A process for the preparation of salts of Saxagliptin of formula I:

(I)
wherein HA is or  
the process comprising:
(a) treating  at a temperature of about 40oC to about 65oC  (S)-N-Boc-3-hydroxyadamantylglycine-L-cis-4 5-methanoprolinenitrile with either: (i) a mineral acid in water or (ii) a mixture of water and an alcoholic solvent  thereby forming a solution;
(b) adding a water-immiscible solvent to the solution  thereby forming a bi-phasic solution;
(c) basifying the bi-phasic solution by adjusting the pH to about 9 to about 9.5  thereby forming a basified bi-phasic solution;
(d) separating an organic phase from the basified bi-phasic solution;
(e) treating the organic phase with an organic acid  thereby forming a treated organic phase; and
(f) isolating the salt of Saxagliptin from the treated organic phase.

20. The process according to claim 19 wherein the mineral acid is hydrochloric acid.

21. The process according to claim 19 or 20 wherein the alcoholic solvent is a C1-C3 alkanol selected from the group consisting of methanol  ethanol  and isopropanol.

22. The process according to any one of claims 19 to 21 wherein the water-immiscible solvent is dichloromethane or ethyl acetate.

23. The process according to claim 21 wherein the organic acid is selected from the group consisting of nicotinic acid and salicylic acid.

Dated this 24th day of May 2012.