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Self Renewing Embryonic Like Pluripotent Stem Cells From Corneal Limbus For Use In Regenerative Therapy And Method Of Producing The Same

Abstract: The present invention provides pluripotent corneal stem cells from limbal biopsies, cultured ex vivo, and purified by magnetic affinity cell sorting (MACS). These cells possess multilineage differentitation potential and self-renewing capability. They could be propagated in culture, where they continuously produce corneal epithelial cells and other cell lineages from ecotodermal origin, neurons, skin mesodermal origin; osteoblasts, chondrocytes, myocytes, skeletal muscle cells, adipocytes, cardiomyocytes, endodermal origin, beta islet cells and hepatocytes, and endothelial cells. This data indicates that self-renewing multipotent stem cells persists in limbus of the cornea and that such cells can be induced to become cells of other organs of all lineages. The mutipotential capacity of these cells, their easy isolation and culture as well as their high ex vivo proliferation capacity makes these cells a promising therapeutic tool. Hence, these pluripotent stem cells may provide new insight into therapy of various degenerative diseases.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
26 February 2004
Publication Number
31/2006
Publication Type
INA
Invention Field
BIOTECHNOLOGY
Status
Email
Parent Application

Applicants

RELIANCE LIFE SCIENCES PRIVATE LIMITED
RELIANCE LIFE SCIENCES PRIVATE LIMITED CHITRAKOOT, 2nd FLOOR, SHREE RAM MILLS COMPOUND, GANPATRAO KADAM MARG, WORLI, MUMBAI-400013

Inventors

1. TOTEY SATISH MAHADEORAO
FLAT NO. 72, 7th FLOOR, A WING, NAPEROL TOWER, R A KIDWAI ROAD, WADALA, MUMBAI-400031
2. KASHYAP SUBHADRA DEVI
B-34, BOMBAY LINKS, SECTOR-17, VASHI, NAVI MUMBAI-400709
3. KHAN FIRDOS ALAM
9/502, NRI COMPLEX, SEAWOOD ESTATE, SECTOR 54-56, NERUL, NAVI MUMBAI-400709
4. PAL RAJARSHI
FLAT NO. 102, PLOT 40, POONAM CHS, SECTOR-14, KOPAR KHAIRANE, NAVI MUMBAI-400709
5. KHANNA APARNA
31/701 SEAWOODS ESTATE, PALMS BEACH ROAD, NERUL, NAVI MUMBAI-400706

Specification

Documents

Application Documents

# Name Date
1 241-mum-2004-abstract(26-2-2004).pdf 2018-08-09
1 241-mum-2004-specification(amanded)-(18-10-2007).pdf 2007-10-18
2 241-mum-2004-cancelled pages(26-2-2004).pdf 2018-08-09
2 241-mum-2004-form 5(18-10-2007).pdf 2007-10-18
3 241-mum-2004-form 3(18-10-2007).pdf 2007-10-18
3 241-mum-2004-claims(26-2-2004).pdf 2018-08-09
4 241-mum-2004-drawing(18-10-2007).pdf 2007-10-18
4 241-mum-2004-correspondence(7-4-2008).pdf 2018-08-09
5 241-MUM-2004-CORRESPONDENCE(IPO)(29-4-2009).pdf 2018-08-09
5 241-MUM-2004-CLAIMS(AMENDED)(18-10-2007).pdf 2007-10-18
6 241-mum-2004-description(complete)-(26-2-2004).pdf 2018-08-09
6 241-MUM-2004-CLAIMS(AMENDED)(14-11-2007).pdf 2007-11-14
7 241-mum-2004-other document(16-11-2007).pdf 2007-11-16
7 241-MUM-2004-DRAWINGS(26-2-2004).pdf 2018-08-09
8 241-mum-2004-form 1(26-2-2004).pdf 2018-08-09
8 241-mum-2004-correspondence(ipo)-(18-11-2008).pdf 2008-11-18
9 241-MUM-2004-CORRESPONDENCE(24-12-2008).pdf 2008-12-24
9 241-mum-2004-form 19(26-2-2004).pdf 2018-08-09
10 241-MUM-2004-CLAIMS(AMENDED)-(24-12-2008).pdf 2008-12-24
10 241-mum-2004-form 2(26-2-2004).pdf 2018-08-09
11 241-MUM-2004-CLAIMS(AMENDED) (24-12-2008).pdf 2008-12-24
11 241-mum-2004-form 2(title page)-(26-2-2004).pdf 2018-08-09
12 241-MUM-2004-CLAIMS(24-12-2008).pdf 2008-12-24
12 241-mum-2004-form 24(28-2-2008).pdf 2018-08-09
13 241-MUM-2004-CANCELLED PAGE(24-12-2008).pdf 2008-12-24
13 241-MUM-2004-FORM 3 (26-2-2004).pdf 2018-08-09
14 241-mum-2004-form 4(28-2-2008).pdf 2018-08-09
14 241-mum-2004-form 5(26-2-2004).pdf 2018-08-09
15 241-mum-2004-form 4(28-2-2008).pdf 2018-08-09
15 241-mum-2004-form 5(26-2-2004).pdf 2018-08-09
16 241-MUM-2004-CANCELLED PAGE(24-12-2008).pdf 2008-12-24
16 241-MUM-2004-FORM 3 (26-2-2004).pdf 2018-08-09
17 241-mum-2004-form 24(28-2-2008).pdf 2018-08-09
17 241-MUM-2004-CLAIMS(24-12-2008).pdf 2008-12-24
18 241-MUM-2004-CLAIMS(AMENDED) (24-12-2008).pdf 2008-12-24
18 241-mum-2004-form 2(title page)-(26-2-2004).pdf 2018-08-09
19 241-MUM-2004-CLAIMS(AMENDED)-(24-12-2008).pdf 2008-12-24
19 241-mum-2004-form 2(26-2-2004).pdf 2018-08-09
20 241-MUM-2004-CORRESPONDENCE(24-12-2008).pdf 2008-12-24
20 241-mum-2004-form 19(26-2-2004).pdf 2018-08-09
21 241-mum-2004-correspondence(ipo)-(18-11-2008).pdf 2008-11-18
21 241-mum-2004-form 1(26-2-2004).pdf 2018-08-09
22 241-MUM-2004-DRAWINGS(26-2-2004).pdf 2018-08-09
22 241-mum-2004-other document(16-11-2007).pdf 2007-11-16
23 241-MUM-2004-CLAIMS(AMENDED)(14-11-2007).pdf 2007-11-14
23 241-mum-2004-description(complete)-(26-2-2004).pdf 2018-08-09
24 241-MUM-2004-CLAIMS(AMENDED)(18-10-2007).pdf 2007-10-18
24 241-MUM-2004-CORRESPONDENCE(IPO)(29-4-2009).pdf 2018-08-09
25 241-mum-2004-drawing(18-10-2007).pdf 2007-10-18
25 241-mum-2004-correspondence(7-4-2008).pdf 2018-08-09
26 241-mum-2004-form 3(18-10-2007).pdf 2007-10-18
26 241-mum-2004-claims(26-2-2004).pdf 2018-08-09
27 241-mum-2004-form 5(18-10-2007).pdf 2007-10-18
27 241-mum-2004-cancelled pages(26-2-2004).pdf 2018-08-09
28 241-mum-2004-specification(amanded)-(18-10-2007).pdf 2007-10-18
28 241-mum-2004-abstract(26-2-2004).pdf 2018-08-09