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"Solid Dispersions Containing An Apoptosis Promoting Agent"
Abstract: A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound, e.g., ABT-263, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
08 December 2011
Publication Number
39/2013
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Applicants
ABBOTT LABORATORIES
100 ABBOTT PARK ROAD, ABBOTT PARK ILLINOIS 60064, USA
Inventors
1. SCHMITT ERIC A.
319 EVERGREEN COURT, LIBERTYVILLE, ILLINOIS 60048, USA
2. TONG PING
6152 INDIAN TRAIL, GURNEE, ILLINOIS 60031, USA
3. HEEMSTRA KATHERINE
641 W. GRAND AVENUE, APT. 4, CHICAGO, ILLINOIS 60654, USA
4. FISCHER CRISTINA M.
2821 N. AUGUSTA DRIVE, LONG GROVE, ILLINOIS 60047, USA
5. WU HUAILIANG
8094 RFD BRECKENRIDGE DRIVE, LONG GROVE, ILLINOIS 60047, USA
6. MILLER JONATHAN MARK
1228 MEADE COURT, LINDENHURST, ILLINOIS 60046, USA
7. LI YANXIA
34056 SULKEY DRIVE, GRAYSLAKE, ILLINOIS, 60030, USA
8. LAFOUNTAINE JUSTIN S.
659 W. RANDOLPH STREET, UNIT 913, CHICAGO, ILLINOIS 60661, USA
Specification
NA
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 9655-DELNP-2011-AbandonedLetter.pdf | 2018-08-10 |
| 1 | 9655-delnp-2011-Correspondence-Others-(09-02-2012).pdf | 2012-02-09 |
| 2 | 9655-delnp-2011-Assignment-(09-02-2012).pdf | 2012-02-09 |
| 2 | 9655-DELNP-2011-FER.pdf | 2017-09-06 |
| 3 | 9655-delnp-2011-Form-3-(08-05-2012).pdf | 2012-05-08 |
| 3 | 9655-delnp-2011-Correspondence Others-(02-05-2016).pdf | 2016-05-02 |
| 4 | 9655-delnp-2011-Form-3-(02-05-2016).pdf | 2016-05-02 |
| 4 | 9655-delnp-2011-Correspondence Others-(08-05-2012).pdf | 2012-05-08 |
| 5 | 9655-delnp-2011-GPA.pdf | 2012-06-15 |
| 5 | 9655-DELNP-2011-Correspondence-Others-(07-11-2014).pdf | 2014-11-07 |
| 6 | 9655-delnp-2011-Form-5.pdf | 2012-06-15 |
| 6 | 9655-DELNP-2011-Form-1-(07-11-2014).pdf | 2014-11-07 |
| 7 | 9655-DELNP-2011-Form-6-(07-11-2014).pdf | 2014-11-07 |
| 7 | 9655-delnp-2011-Form-3.pdf | 2012-06-15 |
| 8 | 9655-delnp-2011-Form-2.pdf | 2012-06-15 |
| 8 | 9655-delnp-2011-Assignment-(13-08-2013).pdf | 2013-08-13 |
| 9 | 9655-delnp-2011-Correspondence-Others-(13-08-2013).pdf | 2013-08-13 |
| 9 | 9655-delnp-2011-Form-1.pdf | 2012-06-15 |
| 10 | 9655-delnp-2011-Drawings.pdf | 2012-06-15 |
| 10 | 9655-delnp-2011-Form-2-(13-08-2013).pdf | 2013-08-13 |
| 11 | 9655-delnp-2011-Description (Complete).pdf | 2012-06-15 |
| 11 | 9655-delnp-2011-GPA-(13-08-2013).pdf | 2013-08-13 |
| 12 | 9655-delnp-2011-Correspondence Others.pdf | 2012-06-15 |
| 12 | 9655-delnp-2011-Correspondence-Others-(15-07-2013).pdf | 2013-07-15 |
| 13 | 9655-delnp-2011-Claims.pdf | 2012-06-15 |
| 13 | 9655-delnp-2011-Form-3-(15-07-2013).pdf | 2013-07-15 |
| 14 | 9655-delnp-2011-Abstract.pdf | 2012-06-15 |
| 15 | 9655-delnp-2011-Claims.pdf | 2012-06-15 |
| 15 | 9655-delnp-2011-Form-3-(15-07-2013).pdf | 2013-07-15 |
| 16 | 9655-delnp-2011-Correspondence Others.pdf | 2012-06-15 |
| 16 | 9655-delnp-2011-Correspondence-Others-(15-07-2013).pdf | 2013-07-15 |
| 17 | 9655-delnp-2011-GPA-(13-08-2013).pdf | 2013-08-13 |
| 17 | 9655-delnp-2011-Description (Complete).pdf | 2012-06-15 |
| 18 | 9655-delnp-2011-Form-2-(13-08-2013).pdf | 2013-08-13 |
| 18 | 9655-delnp-2011-Drawings.pdf | 2012-06-15 |
| 19 | 9655-delnp-2011-Correspondence-Others-(13-08-2013).pdf | 2013-08-13 |
| 19 | 9655-delnp-2011-Form-1.pdf | 2012-06-15 |
| 20 | 9655-delnp-2011-Assignment-(13-08-2013).pdf | 2013-08-13 |
| 20 | 9655-delnp-2011-Form-2.pdf | 2012-06-15 |
| 21 | 9655-delnp-2011-Form-3.pdf | 2012-06-15 |
| 21 | 9655-DELNP-2011-Form-6-(07-11-2014).pdf | 2014-11-07 |
| 22 | 9655-DELNP-2011-Form-1-(07-11-2014).pdf | 2014-11-07 |
| 22 | 9655-delnp-2011-Form-5.pdf | 2012-06-15 |
| 23 | 9655-DELNP-2011-Correspondence-Others-(07-11-2014).pdf | 2014-11-07 |
| 23 | 9655-delnp-2011-GPA.pdf | 2012-06-15 |
| 24 | 9655-delnp-2011-Correspondence Others-(08-05-2012).pdf | 2012-05-08 |
| 24 | 9655-delnp-2011-Form-3-(02-05-2016).pdf | 2016-05-02 |
| 25 | 9655-delnp-2011-Form-3-(08-05-2012).pdf | 2012-05-08 |
| 25 | 9655-delnp-2011-Correspondence Others-(02-05-2016).pdf | 2016-05-02 |
| 26 | 9655-DELNP-2011-FER.pdf | 2017-09-06 |
| 26 | 9655-delnp-2011-Assignment-(09-02-2012).pdf | 2012-02-09 |
| 27 | 9655-delnp-2011-Correspondence-Others-(09-02-2012).pdf | 2012-02-09 |
| 27 | 9655-DELNP-2011-AbandonedLetter.pdf | 2018-08-10 |
Search Strategy
| 1 | 9655DELNP2011searchstrategy_05-09-2017.pdf |