DESC:The following specification particularly describes the invention and the manner in which it is to be performed:

INTRODUCTION
Aspects of the present application relate to solid forms of Tafamidis and preparative processes thereof. Specific aspects relate to crystalline form TLP of Tafamidis and processes for their preparation.
The drug compound having the adopted name “Tafamidis” has chemical name: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid as below.

Tafamidis is a selective stabilizer of transthyretin developed by The Scripps Research Institute and marketed by Pfizer as VYNDAQEL® (Tafamidis meglumine) and VYNDAMAXTM (Tafamidis) oral capsule for the treatment of the cardiomyopathy of wild type or hereditary transthyretin-mediated amyloidosis in adults to reduce cardiovascular mortality and cardiovascular-related hospitalization.
US 7214695 B2 patent first disclosed Tafamidis and its use thereof for the treatment of transthyretin amyloid disease. It further discloses a general procedure for the preparation of benzoxazoles, particularly Tafamidis. US 9249112 B2 patent discloses the meglumine salt of Tafamidis along with its amorphous and crystalline forms. The US 9770441 B2 patent discloses amorphous and crystalline forms (Form 1, 2, 4 and 6) of Tafamidis.
The reported solid forms of Tafamidis are not viable at industrial scale and there remains a need for alternate solid forms of Tafamidis and their preparative processes.

SUMMARY
In an aspect, the present application provides a crystalline Form TLP of Tafamidis, characterized by a PXRD pattern comprising the peaks at about 7.1, 10.7, 11.6 and 12.8° ± 0.2° 2?.
In another aspect, the present application provides a process for the preparation of crystalline Form TLP of Tafamidis, comprising the step of crystallizing from a mixture comprising Tafamidis free acid and L-Proline in suitable solvent(s).
In another aspect, the present application provides a pharmaceutical composition comprising crystalline Form TLP of Tafamidis and atleast one pharmaceutically acceptable excipient.

BRIEF DESCRIPTION OF THE DRAWING
Figure 1 is an illustrative X-ray powder diffraction pattern of crystalline Form-TLP of Tafamidis, prepared by the method of Example 1.
Figure 2 is an illustrative X-ray powder diffraction pattern of crystalline Tafamidis, prepared by the method of Example 2.

DETAILED DESCRIPTION
Aspects of the present application relates to solid form of Tafamidis and the pharmaceutical compositions thereof. Specific aspect of present application relate to crystalline Form TLP of Tafamidis and their preparative processes.
In an aspect, the present application provides a crystalline Form TLP of Tafamidis, characterized by a PXRD pattern comprising the peaks at about 7.1, and 10.7 ± 0.2° 2?. In an embodiment, the crystalline Form TLP is characterized by one or more additional peaks at about 11.6 and 12.8° ± 0.2° 2?. In an embodiment, the present application provides crystalline Form-TLP of Tafamidis, characterized by a powder X-ray diffraction pattern, as illustrated by Figure 1.
In another aspect, the present application provides a process for the preparation of crystalline Form-TLP of Tafamidis, comprising the step of crystallizing from a mixture comprising Tafamidis free acid and L-Proline in suitable solvent(s).
In embodiments, Tafamidis used in this aspect may be obtained by any methods known in the art or a reaction mixture comprising Tafamidis may be used directly.
In embodiments, the crystalline Form TLP may be isolated by separating the solids from the solvent through suitable techniques known in the art such as evaporation, filtration, decantation and the like.
In embodiments, the isolated solid may be dried under suitable drying conditions such as aerial drying, drying under vacuum or inert gas at a suitable temperature of about 25°C or above.
In embodiments, the crystalline forms of Tafamidis of the present application are stable under thermal, humid and stress conditions. Further, the crystalline forms of present application exhibits superior solubility in solvents such as water, as compared to reported crystalline forms of Tafamidis.
In another aspect, the present application provides a crystalline Form TLP Tafamidis, and its the pharmaceutical compositions thereof, comprising Tafamidis with a chemical purity of atleast 99% by HPLC or atleast 99.5% by HPLC or atleast 99.9% by HPLC.
Certain specific aspects and embodiments of the present application will be explained in greater detail with reference to the following examples, which are provided only for purposes of illustration and should not be construed as limiting the scope of the application in any manner. Variations of the described procedures, as will be apparent to those skilled in the art, are intended to be within the scope of the present application.

Definitions
The term "about" when used in the present application preceding a number and referring to it, is meant to designate any value which lies within the range of ±10%, preferably within a range of ±5%, more preferably within a range of ±2%, still more preferably within a range of ±1 % of its value. For example "about 10" should be construed as meaning within the range of 9 to 11 , preferably within the range of 9.5 to 10.5, more preferably within the range of 9.8 to 10.2, and still more preferably within the range of 9.9 to 10.1.

Examples
Example-1: Preparation of crystalline Form TLP of Tafamidis.
A mixture of Tafamidis (100 mg) and L-Proline (75mg) was dissolved in 1:1v/v mixture isopropanol and acetonitrile (100 mL) followed by sonication. The mixture was subjected to evaporation at ~85oC followed by drying to afford the title crystalline Form TLP of Tafamidis.

Example-2: Preparation of crystalline Form of Tafamidis.
A mixture of Tafamidis (500 mg) was dissolved in 20mLTetrahydrofuran (THF) at ~75oC. The said mixture was added to a precooled 1:1 (v/v) mixture of ethanol and propylene glycol (50ml:50ml) at 0oC followed by stirring at the same temperature for about an hour. The mixture was cooled and the solid obtained was isolated followed by drying to afford the title crystalline Form of Tafamidis, having ethanol ~4.5% and THF ~0.9%.

Example-3: Preparation of crystalline Form TLP of Tafamidis.
A mixture of Tafamidis (20 mg) was dissolved in Tetrahydrofuran (600mL) at ~45-50oC. Then a solution of L-Proline (14.93 g) in methanol (100mL) was prepared at room temperature. Then, these two solutions were simultaneously charged to acetonitrile (400mL) at room temperature. The mixture was stirred for 5-6 hours at 20-25oC. The obtained solid was filtered under vacuum and dried in VTD at 60-65°C about 6-8 hours to afford the title compound.
,CLAIMS:We claim,

Claim 1: A crystalline Form TLP of Tafamidis, characterized by a PXRD pattern comprising the peaks at about 7.1, 10.7, 11.6 and 12.8° ± 0.2° 2?.

Claim 2: A process for the preparation of crystalline Form TLP of Tafamidis, comprising the step of crystallizing from a mixture comprising Tafamidis free acid and L-Proline in suitable solvent(s).

Claim 3: The process of claim 2, wherein solvents are selected from alcohols, ethers, esters, ketones, aromatic hydrocarbons, polar aprotic solvents and mixtures thereof.

Claim 4: The process of claim 3 wherein solvents are selected from methanol, ethanol, propylene glycol, Tetrahydrofuran, acetonitrile and mixtures thereof.

Claim 5: A pharmaceutical composition comprising crystalline Form TLP of Tafamidis and at least one pharmaceutically acceptable excipient.