"Stable Antibody Compositions And Methods For Stabilizing Same"

Abstract: The invention provides compositions and methods for Inhibiting fractionation of immunoglobulins comprising a lambda light chain based on the observation that iron, in the presence of histidine, results in increased fragmentation of a recombinant fully human IgG molecule containing a lambda light chain due to cleavage in the hinge region. The invention further provides an aqueous pharmaceutical formulation comprising an antibody, or antigen-binding portion thereof, that binds the p40 subunit of IL-12/IL-23 and a buffer system comprising histidine, wherein the formulation has enhanced stability, including enhanced resistance to fragmentation.

Patent Information

Application #

Filing Date

04 May 2011

Publication Number

13/2012

Publication Type

INA

Invention Field

PHYSICS

Status

Email

Parent Application

Applicants

ABBOTT LABORATORIES

100 ABBOTT PARK ROAD, ABBOTT PARK, IL 60064-6008, U.S.A.

Inventors

1. CORREIA IVAN R.

55 POND STREET, WINCHESTER, MASSACHUSETTS 01890, U.S.A.

2. RADZIEJEWSKI CZESLAW H.

3 BLOSSOM COURT WESTBOROUGH, MA 01581, U.S.A.

3. FRAUNHOFER WOLFGANG

5 JOHN STREET SHREWSBURY, MA 01545, U.S.A.

4. WARNE NICHOLAS W.

27 FARRWOOD DRIVE ANDOVER, MA 01810, U.S.A.

5. KANTOR ANGELA

118 SOUTH ROAD PEPPERELL, MA 01463, U.S.A.