"Stable Nanoparticulate Drug Suspension"

Abstract: A liquid pharmaceutical composition comprises an aqueous medium having suspended therein a solid particulate Bcl-2 family protein inhibitory compound such as ABT-263, having a D90 particle size not greater than about 3 µm; wherein the aqueous medium further comprises at least one pharmaceutically acceptable surfactant and at least one pharmaceutically acceptable basifying agent such as sodium bicarbonate in amounts that are effective together to inhibit particle size increase. The composition is suitable for oral or parenteral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

Patent Information

Application #

Filing Date

13 December 2011

Publication Number

08/2013

Publication Type

INA

Invention Field

TRADITIONAL KNOWLEDGE BIOTECHNOLOGY

Status

Email

Parent Application

Applicants

ABBOTT LABORATORIES

100 ABBOTT PARK ROAD, ABBOTT PARK, ILLINOIS 60064, USA

Inventors

1. GOKHALE RAJEEV

2250 HANLON ROAD, LIBERTYVILLE, ILLINOIS 60048, USA

2. MARSH KENNAN C.

1499 MCKINLEY ROAD, LAKE FOREST, ILLINOIS 60045, USA

3. SHI YI

1404 JAMES COURT, LIBERTYVILLE, ILLINOIS 60048, USA

Specification

NA

Documents

Application Documents

#	Name	Date
1	9817-delnp-2011-Assignment-(13-08-2013).pdf	2013-08-13
1	9817-delnp-2011-Correspondence-Others-(09-02-2012).pdf	2012-02-09
2	9817-delnp-2011-Assignment-(09-02-2012).pdf	2012-02-09
2	9817-delnp-2011-Correspondence-Others-(13-08-2013).pdf	2013-08-13
3	9817-delnp-2011-Form-3-(08-05-2012).pdf	2012-05-08
3	9817-delnp-2011-Form-2-(13-08-2013).pdf	2013-08-13
4	9817-delnp-2011-GPA-(13-08-2013).pdf	2013-08-13
4	9817-delnp-2011-Correspondence Others-(08-05-2012).pdf	2012-05-08
5	9817-delnp-2011-GPA.pdf	2012-07-20
5	9817-delnp-2011-Abstract.pdf	2012-07-20
6	9817-delnp-2011-Form-5.pdf	2012-07-20
6	9817-delnp-2011-Claims.pdf	2012-07-20
7	9817-delnp-2011-Form-3.pdf	2012-07-20
7	9817-delnp-2011-Correspondence Others.pdf	2012-07-20
8	9817-delnp-2011-Form-2.pdf	2012-07-20
8	9817-delnp-2011-Description (Complete).pdf	2012-07-20
9	9817-delnp-2011-Drawings.pdf	2012-07-20
9	9817-delnp-2011-Form-1.pdf	2012-07-20
10	9817-delnp-2011-Drawings.pdf	2012-07-20
10	9817-delnp-2011-Form-1.pdf	2012-07-20
11	9817-delnp-2011-Description (Complete).pdf	2012-07-20
11	9817-delnp-2011-Form-2.pdf	2012-07-20
12	9817-delnp-2011-Correspondence Others.pdf	2012-07-20
12	9817-delnp-2011-Form-3.pdf	2012-07-20
13	9817-delnp-2011-Claims.pdf	2012-07-20
13	9817-delnp-2011-Form-5.pdf	2012-07-20
14	9817-delnp-2011-Abstract.pdf	2012-07-20
14	9817-delnp-2011-GPA.pdf	2012-07-20
15	9817-delnp-2011-Correspondence Others-(08-05-2012).pdf	2012-05-08
15	9817-delnp-2011-GPA-(13-08-2013).pdf	2013-08-13
16	9817-delnp-2011-Form-2-(13-08-2013).pdf	2013-08-13
16	9817-delnp-2011-Form-3-(08-05-2012).pdf	2012-05-08
17	9817-delnp-2011-Assignment-(09-02-2012).pdf	2012-02-09
17	9817-delnp-2011-Correspondence-Others-(13-08-2013).pdf	2013-08-13
18	9817-delnp-2011-Correspondence-Others-(09-02-2012).pdf	2012-02-09
18	9817-delnp-2011-Assignment-(13-08-2013).pdf	2013-08-13