Subsituted Phenylsulfonamide Inhibitors Of Beta Amyloid Production

Abstract: Compounds of Formula I, wherein R1-R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and for the prevention and treatment of Alzheimer's Disease and Down's syndrome are described.

Patent Information

Application #

Filing Date

03 April 2007

Publication Number

29/2007

Publication Type

INA

Invention Field

PHARMACEUTICALS

Status

Email

Parent Application

Applicants

WYETH

FIVE GIRALDA FARMS, MADISON, NJ

ARQULE, INC.

19 PRESIDENTIAL WAY, WOBURN, MA

Inventors

1. KREFT ANTHONY FRANK

43 BARLEY COURT, LANGHORNE, PA 19047

2. COLE DEREK CECIL

14 RENFREW ROAD, NEW CITY, NY 10956

3. WOLLER KEVIN ROGER

2 AMANDREY WAY, AYER, MA 01432

4. STOCK JOSEPH RAYMOND

439 HIGH STREET, MONROE, NY 10950

5. KUTTERER KRISTINA MARTHA

624 CAMBELL PLACE, WESTWOOD, NJ 07675

6. KUBRAK DENNIS MARTIN

3231 GAUL STREET, PHILADELPHIA, PA 19134

7. MANN CHARLES WILLIAM

122 SOUTH FIFTH STREET, NORTH WALES, PA 19454

8. MOORE WILLIAM JAY

108 FOX RUN DRIVE, COLLEGEVILLE, PA 19426

9. CASEBIER DAVID SCOTT

161 EMBER LANE, CARLISLE, MA 01741

Specification

Compounds of Formula I, wherein R1-R8 are defined herein are provided, together with
pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these
compounds for inhibiting beta amyloid production and for the prevention and treatment of
Alzheimer's Disease and Down's syndrome are described.

Documents

Application Documents

#	Name	Date
1	abstract-01149-kolnp-2007.jpg	2011-10-07
2	1149-KOLNP-2007-CORRESPONDENCE.pdf	2011-10-07
3	01149-kolnp-2007-gpa.pdf	2011-10-07
4	01149-kolnp-2007-form 5.pdf	2011-10-07
5	01149-kolnp-2007-form 3.pdf	2011-10-07
6	01149-kolnp-2007-form 2.pdf	2011-10-07
7	01149-kolnp-2007-form 18.pdf	2011-10-07
8	01149-kolnp-2007-form 1.pdf	2011-10-07
9	01149-kolnp-2007-description complete.pdf	2011-10-07
10	01149-kolnp-2007-correspondence others.pdf	2011-10-07
11	01149-kolnp-2007-correspondence others 1.2.pdf	2011-10-07
12	01149-kolnp-2007-correspondence others 1.1.pdf	2011-10-07
13	01149-kolnp-2007-claims.pdf	2011-10-07
14	01149-kolnp-2007-assignment.pdf	2011-10-07
15	01149-kolnp-2007-abstract.pdf	2011-10-07
16	1149-KOLNP-2007_EXAMREPORT.pdf	2016-06-30
17	1149-KOLNP-2007-ABANDONED LETER.pdf	2017-06-22
18	1149-KOLNP-2007-FIRST EXAMINATION REPORT.pdf	2018-07-03
19	01149-kolnp-2007-priority document.pdf	2018-07-04