Substituted 2 Chroman 6 Yloxy Thiazoles And Their Use As Pharmaceuticals

Abstract: The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.

100% Free

Patent Information

Applicants

Inventors

Specification

Documents

Application Documents

#	Name	Date
1	3127-CHE-2011 FORM-3 12-09-2011.pdf	2011-09-12
2	3127-CHE-2011 FORM-2 12-09-2011.pdf	2011-09-12
3	3127-CHE-2011 FORM-1 12-09-2011.pdf	2011-09-12
4	3127-CHE-2011 DESCRIPTION (COMPLETE) 12-09-2011.pdf	2011-09-12
5	3127-CHE-2011 DESCRIPTION (COMPLETE) 1 12-09-2011.pdf	2011-09-12
6	3127-CHE-2011 CORRESPONDENCE OTHERS 12-09-2011.pdf	2011-09-12
7	3127-CHE-2011 CLAIMS 12-09-2011.pdf	2011-09-12
8	3127-CHE-2011 ABSTRACT 12-09-2011.pdf	2011-09-12
9	3127-CHE-2011 FORM-1 21-02-2012.pdf	2012-02-21
10	3127-CHE-2011 CORRESPONDENCE OTHERS 21-02-2012.pdf	2012-02-21
11	abstract3127-CHE-2011.jpg	2012-11-23
12	Marked Copy [07-09-2015(online)].pdf	2015-09-07
13	Form 13 [07-09-2015(online)].pdf	2015-09-07
14	Description(Complete) [07-09-2015(online)].pdf	2015-09-07
15	3127-CHE-2011 FORM-13 07-09-2015.pdf	2015-09-07
16	3127-CHE-2011-Other Patent Document-070915.pdf	2015-11-23
17	3127-CHE-2011-FER.pdf	2019-01-29
18	3127-CHE-2011-AbandonedLetter.pdf	2019-07-31

Search Strategy

1	Search_27-12-2018.pdf