Abstract: The present application relates to a series of substituted imidazo[l 2 a]pyridine compounds of formula (I) pharmaceutically acceptable salts pharmaceutically acceptable solvates or stereoisomers thereof their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors method of making and pharmaceutical compositions comprising such compounds.
What is claimed is
1. A compound having the formula (I),
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable
solvates thereof or stereoisomers thereof,
wherein,
R1 is -Xa-Ra;
R2 is -Xb-Rb;
Xa is a 3-7 membered heterocyclyl selected from aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, azepanyl, thiomorpholinyl, 1,1-dioxo-thiomorphonyl and morpholinyl, any of which is optionally substituted with 1-3 times with R3;
R3, in each occurrence is selected independently from halogen, hydroxy, -(C1-C6)alkyl, -(C1-C6)alkoxy and halo(C1-C6)alkoxy;
Ra is a phenyl ring optionally substituted 1-3 times with R4;
R4, in each occurrence is selected independently from halogen, -(C1-C6)alkyl and -O-R5;
Alternatively, two R4, on adjacent carbon atoms, together with the carbon atoms to which they are attached may form a 5-6 membered heterocyclyl or a 5-6 membered heteroaryl ring;
R5 is selected from -(C1-C6)alkyl, halo(C1-C6)alkyl and 5-6 membered heterocyclyl;
Xb is selected from -CO-, -CONR6-, -NR6CO-, -C(=N-OR6)-, -CONR6-SO2-, -CONR6-SO2-NR6-, and -R6N-CO-NR6;
Rb is selected from
(i) alkyl, optionally substituted with 1-3 substituents selected independently from halogen, -(C1-C6)alkoxy, hydroxyl and -CO-(CR7R8)p-OR9;
(ii) aryl, heteroaryl or cycloalkyl, any of which is optionally substituted with 1-3 substituents selected independently from halogen, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, -(C1-C6)alkoxy, hydroxyl, -(C1-C6)alkyl and -R10;
(iii) heterocyclyl, optionally substituted with 1-3 substituents selected independently from halogen, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, -(C1-C6)alkoxy, hydroxyl, -(C1-C6)alkyl, and N(Ri)2,. wherein Ri, in each occurrence, independently selected from hydrogen, -(C1-C6)alkyl or -(C3-C6)alkyl;
Alternatively, R6 and Rb together with Nitrogen atom to which they are attached, may form a 3-10 membered heterocyclic ring optionally substituted 1-3 times with R11;
R6, in each occurrence, is independently selected from hydrogen, -(C1-C6)alkyl and -(C1-C6)alkyl-(C3-C6)cycloalkyl;
R7, R8 or R9, in each occurrence, is independently selected from hydrogen and -(C1-C6)alkyl;
R10 is a 5-6 membered heterocyclyl or a 5-6 membered heteroaryl, any of which is optionally substituted with 1-2 substituents selected independently from -(C1-C6)alkyl, halogen, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, -(C1-C6)alkoxy and hydroxyl;
R11 is selected from halogen, hydroxyl, alkyl and –NH2; and
p is 0, 1, 2 or 3.
2. The compound according to claim 1, having the formula (Ia):
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof, wherein
‘n’ is 1, 2 or 3;
‘m’ is 1, 2 or 3;
‘q’ is 0, 1, 2 or 3;
R2, R3, and R4 are as described in claim 1.
3. The compound according to claim 1, having the formula (Id):
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof, wherein
‘m’ is 1 or 2;
‘n’ is 1, 2 or 3;
‘q’ is 0 or 1;
R2, R3, and R4 are as described in claim 1.
4. The compound according to claim 1, having the formula (Ie):
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof, wherein
‘m’ is 1 or 2;
‘n’ is 1, 2 or 3;
‘q’ is 0 or 1;
R2, R3, and R4 are as described in claim 1.
5. The compound according to claim 1, having the formula (Ig):
F
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof, wherein
R3 is halogen; ‘q’ is 0 or 1; R2 and R4 are as described in claim 1.
6. The compound according to claim 1, having the formula (Ij):
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof, wherein
‘q’ is 0 or 1;
R2 and R4 are as described in claim 1.
7. The compound according to claim 1, having the formula (Ik):
i- v ' (Ik)
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof, wherein
R2 and R5 are as described in claim 1.
8. The compound according to claim 1, having the formula (Il):
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof, wherein
R3 is halogen;
‘m’ is 1 or 2;
‘q’ is 0 or 1;
R2 is as described in claim 1.
9. The compound according to claim 1, wherein R2 is –CO-Rb, –CONH-Rb, – CONCH3-Rb, -NHCO-Rb, -C(=N-OH)-Rb, -CONH-SO2-Rb, -CON(CH3)-SO2-Rb, -CONH-SO2-NH-Rb, -CONH-SO2-N(CH3)-Rb, -CONH-SO2-N(CH2CH3)-Rb, -CONH-SO2-N(CH2CH2CH3)-Rb, -CONH-SO2-N(cyclopropylmethyl)-Rb or -NH-CO-NH-Rb.
10. The compound according to claim 1, wherein Rb is
(i) methyl, ethyl, propyl, tert-butyl, isobutyl, propan-2-yl or 2-methylpropan-2-yl, any of which is optionally substituted with 1-3 substituents independently selected from fluorine, methoxy, hydroxyl, -COOCH2CH3 and – COOH;
(ii) phenyl, pyridin-2-yl, pyridin-3-yl, pyrazin-2-yl, pyridazin-3-yl, thiazol-2-yl, 1,3,4-thiadiazol-2-yl, 1H-pyrazol-3-yl, cyclopropyl, cyclohexyl or amantan-1-yl, any of which is optionally substituted with 1-3 substituents independently selected from fluorine, fluoromethyl, difluoromethyl, trifluoromethyl, fluoromethoxy, methoxy, ethoxy, hydroxyl, methyl, 3-hydroxypyrrolidin-1-yl, piperidin-1-yl, 1,2,4-triazol-1-yl and 1H-imidazol-1-yl; or
(iii) pyrrolidin-1-yl, azetidin-1-yl, piperidin-1-yl, morpholino, piperazin-1-yl, azepan-1-yl or tetrahydro-2H-pyran-4-yl, optionally substituted with 1-3 substituents independently selected from fluorine, fluoromethyl, difluoromethyl, trifluoromethyl, fluoromethoxy, methoxy, hydroxyl, -NH2 and methyl.
11. The compound according to claim 1, wherein R4 is independently selected from
fluorine, methoxy, 2-fluoroethoxy, (tetrahydrofuranyl)oxy, (tetrahydropyranyl)oxy,
(tetrahydrofuran-3-yl)oxy, (tetrahydro-2H-pyran-4-yl)oxy or (R)-(tetrahydrofuran-
3-yl)oxy; or R4 on two carbon adjacent atoms, together with the carbon atoms to which they are attached form a 1,4-dioxine ring.
12. The compound according to claim 1, wherein
R1 is -Xa-Ra;
R2 is –CO-Rb, –CONH-Rb, –CONCH3-Rb, -NHCO-Rb, -C(=N-OH)-Rb, -CONH-SO2-Rb, -CON(CH3)-SO2-Rb, -CONH-SO2-NH-Rb, -CONH-SO2-N(CH3)-Rb, -CONH-SO2-N(CH2CH3)-Rb, -CONH-SO2-N(CH2CH2CH3)-Rb, -CONH-SO2-N(cyclopropylmethyl)-Rb or -NH-CO-NH-Rb;
Xa is pyrrolidinyl or piperidinyl ring, optionally substituted with fluorine;
Ra is a phenyl ring optionally substituted 2-3 times with R4;
R4 is independely selected from fluorine, methoxy, 2-fluoroethoxy, (tetrahydrofuranyl)oxy, (tetrahydropyranyl)oxy, (tetrahydrofuran-3-yl)oxy, (tetrahydro-2H-pyran-4-yl)oxy or (R)-(tetrahydrofuran-3-yl)oxy; or
R4 on two adjacent carbon atoms, together with the carbon atoms to which they are attached form a 1,4-dioxine ring.
Rb is methyl, ethyl, propyl, tert-butyl, -CH2C(O)OCH2CH3, -CH2C(O)OH, 2-hydroxyethyl, 1,3-dihydroxypropan-2-yl, 1,3-dihydroxy-2-methylpropan-2-yl, 1-hydroxy-2-methylpropan-2-yl, (S)-2,3-dihydroxypropyl, (S)-1-hydroxypropan-2-yl, 2-fluoroethyl, 2,2-difluoroethyl, 2-fluoro-2-methylpropyl, 2,2,2-trifluoroethyl, 2-methoxyethyl, 2-ethoxyethyl, cyclopropyl, 1-methylcyclopropyl, (1r,4r)-4-hydroxycyclohexyl, 3-hydroxyadamantan-1-yl, 3-hydroxyazetidin-1-yl, 3-hydroxy-3-methylazetidin-1-yl, (S)-3-aminopyrrolidin-1-yl), (S)-3-hydroxypyrrolidin-1-yl, piperidin-1-yl, 4-hydroxypiperidin-1-yl, morpholinyl, 4-methylpiperazinyl, tetrahydro-2H-pyran-4-yl, 4-hydroxyazepan-1-yl, thiazol-2-yl, 5-methyl-1,3,4-thiadiazol-2-yl, 1,3,4-thiadiazol-2-yl, 1H-1,2,4-triazol-1-yl, (1-methyl-1H-pyrazol-3-yl), 1H-imidazol-1-yl, 6-methylpyridazin-3-yl, pyridin-2-yl, pyridin-3-yl, pyrazin-2-yl, 4-fluorophenyl, ((S)-3-hydroxypyrrolidin-1-yl)phenyl or ((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl.
13. The compound according to claim 1, selected from
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(4-fluorophenyl)imidazo[1,2-
a]pyridine-3-carboxamide;
N-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)-3-hydroxypyrrolidine-1-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(3-hydroxypyrrolidin-1-yl)methanone;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(3-hydroxyazetidin-1-yl)methanone;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(1,3-dihydroxypropan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(morpholino)methanone;
N-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)morpholine-4-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N,N-dimethylimidazo[1,2-a]pyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(4-fluorophenyl)methanone;
3-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)-1,1-dimethylurea;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(3-hydroxypyrrolidin-1-yl)methanone;
N-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)acetamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(4-fluorophenyl)methanone oxime;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(4-fluorophenyl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(4-hydroxycyclohexyl)imidazo[1,2-a]pyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(4-hydroxypiperidin-1-yl)methanone;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(3-ethoxy-2-oxopropyl)imidazo[1,2-a]pyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carbonyl)glycine;
2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamido)acetic acid;
(3-aminopyrrolidin-1-yl)(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)methanone;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(2-hydroxyethyl)imidazo[ 1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(2-hydroxyethyl)imidazo[ 1,2-a]pyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)((S)-3-hydroxypyrrolidin-1 -yl)methanone;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(4-fluorophenyl)methanone oxime;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(4-fluorophenyl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1r,4R)-4-hydroxycyclohexyl)imidazo[1,2-a]pyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(4-hy droxypiperidin-1 -yl)methanone;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(3-ethoxy-2-oxopropyl)imidazo[1,2-a]pyridine-3-carboxamide;
Ethyl 2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-
carboxamido) acetate;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carbonyl)glycine;
2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamido)acetic acid;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(2-hydroxyethyl)imidazo[1,2-a]pyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(4-hydroxyazepan-1-yl)methanone;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1r,3S,5R,7S)-3-hydroxyadamantan-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(1,3-dihydroxy-2-methylpropan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((S)-2,3-dihydroxypropyl)imidazo[1,2-a]pyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(3-hydroxy-3-methylazetidin-1-yl)methanone;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((S)-1-hydroxypropan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(1-hydroxy-2-methylpropan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(tetrahydro-2H-pyran-4-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-ethyl-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-((4-(1H-1,2,4-triazol-1-yl)phenyl)sulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-ethyl-N-(2-fluoroethyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(2,2,2-trifluoroethyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(pyridin-3-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-(cyclopropylmethyl)-N-(pyridin-3-yl)sulfamoyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(pyrazin-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-((6-(1H-imidazol-1-yl)pyridin-3-yl)sulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((4-(3-hydroxypyrrolidin-1-yl)phenyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N-(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(4-fluoro-2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-(2R)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-((2S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-(4-fluoro-2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-(N-ethyl-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
1-(6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)-N-(2-fluoroethyl)-N-methyl-1-oxomethanesulfonamide;
(tert-butylsulfonyl)(6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)methanone;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(pyrazin-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-((6-(1H-imidazol-1-yl)pyridin-3-yl)sulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N,N-diethylsulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-(( tetrahydrofuran-3-
yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-(2-fluoroethyl)sulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(6-methylpyridazin-3-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide
N-(tert-butylsulfonyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-(2-ethoxyethyl)-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(6-methylpyridazin-3-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N,N-diethylsulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-(2-fluoroethyl)sulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N,N-dimethylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-cyclopropyl-N-methylsulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-(2,2-difluoroethyl)-N-methylsulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide; and
N-(N,N-diethylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof or a stereoisomer thereof.
14. The compound according to claim 1, selected from
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(2-hydroxyethyl)imidazo[1,2-a]pyridine-3-carboxamide;
(S)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(2-hydroxyethyl)imidazo[1,2-a]pyridine-3-carboxamide;
(3S)-N-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)-3-hydroxypyrrolidine-1-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)((S)-3-hydroxypyrrolidin-1-yl)methanone;
(6-((S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)((S)-3-hydroxypyrrolidin-1-yl)methanone;
(6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)((S)-3-hydroxypyrrolidin-1-yl)methanone;
(Z/E)(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(4-fluorophenyl)methanone oxime;
(E/Z)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(4-fluorophenyl)methanone oxime;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(4-fluorophenyl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide;
(S)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(4-fluorophenyl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide;
6-((S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1r,4S)-4-hydroxycyclohexyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1r,4R)-4-hydroxycyclohexyl)imidazo[1,2-a]pyridine-3-carboxamide;
(S)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(4-hy droxypiperidin-1 -yl)methanone;
(R)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(4-hy droxypiperidin-1 -yl)methanone;
(S)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(3-ethoxy-2-oxopropyl)imidazo[1,2-a]pyridine-3-carboxamide;
Ethyl (S)-2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamido) acetate;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(3-ethoxy-2-oxopropyl)imidazo[1,2-a]pyridine-3-carboxamide;
Ethyl (R)-2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamido) acetate;
(S)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carbonyl)glycine;
(S)-2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamido)acetic acid;
(R)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carbonyl)glycine;
(R)-2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamido)acetic acid;
((S)-3-aminopyrrolidin-1-yl)(6-((S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)methanone;
((S)-3-aminopyrrolidin-1-yl)(6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)methanone;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(2-hydroxyethyl)imidazo[1,2-a]pyridine-3-carboxamide;
(S)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(2-hydroxyethyl)imidazo[1,2-a]pyridine-3-carboxamide;
(6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(4-hy droxy azepan-1 -yl)methanone;
6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1r,3S,5R,7S)-3-hydroxyadamantan-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(1,3-dihydroxy-2-methylpropan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((S)-2,3-dihydroxypropyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(3-hydroxy-3-methylazetidin-1-yl)methanone;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1 -yl)-N-(piperidin-1 -yl)imidazo[ 1,2-a]pyridine-3-carboxamide;
6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((S)-1-hydroxypropan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(1-hydroxy-2-methylpropan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(tetrahydro-2H-pyran-4-yl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-N-(tert-butylsulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-ethyl-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-N-((4-(1H-1,2,4-triazol-1-yl)phenyl)sulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-ethyl-N-(2-fluoroethyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(2,2,2-trifluoroethyl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(pyridin-3-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-N-(N-(cyclopropylmethyl)-N-(pyridin-3-yl)sulfamoyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(pyrazin-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-N-((6-(1H-imidazol-1-yl)pyridin-3-yl)sulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N-(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-N-(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1 -yl)-N-((1 -methylcyclopropyl)sulfonyl)imidazo[ 1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1 -yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo [1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1 -yl)imidazo[ 1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-N-(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-N-(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
1-(6-((2S,4R)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1 -yl)imidazo [ 1,2-a] pyridin-3 -yl)-N-(2-fluoroethyl)-N-methyl-1 -oxomethanesulfonamide;
(tert-butylsulfonyl)(6-((2S,4R)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)methanone;
(S)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(3-hydroxyazetidin-1 -yl)methanone;
(R)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridin-3-yl)(3-hydroxyazetidin-1 -yl)methanone;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(pyrazin-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-N-((6-(1H-imidazol-1-yl)pyridin-3-yl)sulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N,N-diethylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1 -yl)imidazo[ 1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-(2-fluoroethyl)sulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1 -yl)imidazo[ 1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1 -yl)-N-(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo[ 1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1 -yl)-N-(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo[ 1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(6-methylpyridazin-3-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide
(R)-N-(tert-butylsulfonyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-N-(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy) phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-N-(N-(2-ethoxyethyl)-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(6-methylpyridazin-3-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1 -yl)-N-(N-methyl-N-propylsulfamoyl)imidazo [ 1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1 -yl)-N-(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo[ 1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N,N-diethylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-(2-fluoroethyl)sulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N,N-dimethylsulfamoyl)-6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-cyclopropyl-N-methylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-(2,2-difluoroethyl)-N-methylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N,N-diethylsulfamoyl)-6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-((2S,4R)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide;
6-((2S,4R)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo[1,2-a]pyridine-3-carboxamide;
N-(N-ethyl-N-methylsulfamoyl)-6-((2S,4R)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide; and
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N-methyl-N-propylsulfamoyl)imidazo[1,2-a]pyridine-3-carboxamide;
or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof or a stereoisomer thereof.
15. A pharmaceutical composition comprising at least one compound as claimed in the claim 1 and at least one pharmaceutically acceptable excipient.
| # | Name | Date |
|---|---|---|
| 1 | 201647042606-RELEVANT DOCUMENTS [16-03-2020(online)].pdf | 2020-03-16 |
| 1 | Form 5 [14-12-2016(online)].pdf | 2016-12-14 |
| 2 | 201647042606-IntimationOfGrant30-04-2019.pdf | 2019-04-30 |
| 2 | Form 3 [14-12-2016(online)].pdf | 2016-12-14 |
| 3 | Form 18 [14-12-2016(online)].pdf | 2016-12-14 |
| 3 | 201647042606-PatentCertificate30-04-2019.pdf | 2019-04-30 |
| 4 | Description(Complete) [14-12-2016(online)].pdf_100.pdf | 2016-12-14 |
| 4 | Abstract_Granted 312057_30-04-2019.pdf | 2019-04-30 |
| 5 | Description(Complete) [14-12-2016(online)].pdf | 2016-12-14 |
| 5 | Claims_Granted 312057_30-04-2019.pdf | 2019-04-30 |
| 6 | Description_Granted 312057_30-04-2019.pdf | 2019-04-30 |
| 6 | 201647042606.pdf | 2016-12-16 |
| 7 | Marked Up Claims_Granted 312057_30-04-2019.pdf | 2019-04-30 |
| 7 | Form 3 [17-02-2017(online)].pdf | 2017-02-17 |
| 8 | Marked Copy [26-04-2017(online)].pdf | 2017-04-26 |
| 8 | 201647042606-ABSTRACT [29-04-2019(online)].pdf | 2019-04-29 |
| 9 | 201647042606-CLAIMS [29-04-2019(online)].pdf | 2019-04-29 |
| 9 | Form 13 [26-04-2017(online)].pdf | 2017-04-26 |
| 10 | 201647042606-COMPLETE SPECIFICATION [29-04-2019(online)].pdf | 2019-04-29 |
| 10 | Description(Complete) [26-04-2017(online)].pdf_115.pdf | 2017-04-26 |
| 11 | 201647042606-CORRESPONDENCE [29-04-2019(online)].pdf | 2019-04-29 |
| 11 | Description(Complete) [26-04-2017(online)].pdf | 2017-04-26 |
| 12 | 201647042606-FER_SER_REPLY [29-04-2019(online)].pdf | 2019-04-29 |
| 12 | Form1_After Filing_28-04-2017.pdf | 2017-04-28 |
| 13 | 201647042606-OTHERS [29-04-2019(online)].pdf | 2019-04-29 |
| 13 | Correspondence by Agent_Form1_28-04-2017.pdf | 2017-04-28 |
| 14 | 201647042606-FER.pdf | 2018-10-31 |
| 14 | Form 3 [07-06-2017(online)].pdf | 2017-06-07 |
| 15 | 201647042606-FER.pdf | 2018-10-31 |
| 15 | Form 3 [07-06-2017(online)].pdf | 2017-06-07 |
| 16 | 201647042606-OTHERS [29-04-2019(online)].pdf | 2019-04-29 |
| 16 | Correspondence by Agent_Form1_28-04-2017.pdf | 2017-04-28 |
| 17 | Form1_After Filing_28-04-2017.pdf | 2017-04-28 |
| 17 | 201647042606-FER_SER_REPLY [29-04-2019(online)].pdf | 2019-04-29 |
| 18 | 201647042606-CORRESPONDENCE [29-04-2019(online)].pdf | 2019-04-29 |
| 18 | Description(Complete) [26-04-2017(online)].pdf | 2017-04-26 |
| 19 | 201647042606-COMPLETE SPECIFICATION [29-04-2019(online)].pdf | 2019-04-29 |
| 19 | Description(Complete) [26-04-2017(online)].pdf_115.pdf | 2017-04-26 |
| 20 | 201647042606-CLAIMS [29-04-2019(online)].pdf | 2019-04-29 |
| 20 | Form 13 [26-04-2017(online)].pdf | 2017-04-26 |
| 21 | 201647042606-ABSTRACT [29-04-2019(online)].pdf | 2019-04-29 |
| 21 | Marked Copy [26-04-2017(online)].pdf | 2017-04-26 |
| 22 | Form 3 [17-02-2017(online)].pdf | 2017-02-17 |
| 22 | Marked Up Claims_Granted 312057_30-04-2019.pdf | 2019-04-30 |
| 23 | 201647042606.pdf | 2016-12-16 |
| 23 | Description_Granted 312057_30-04-2019.pdf | 2019-04-30 |
| 24 | Claims_Granted 312057_30-04-2019.pdf | 2019-04-30 |
| 24 | Description(Complete) [14-12-2016(online)].pdf | 2016-12-14 |
| 25 | Description(Complete) [14-12-2016(online)].pdf_100.pdf | 2016-12-14 |
| 25 | Abstract_Granted 312057_30-04-2019.pdf | 2019-04-30 |
| 26 | Form 18 [14-12-2016(online)].pdf | 2016-12-14 |
| 26 | 201647042606-PatentCertificate30-04-2019.pdf | 2019-04-30 |
| 27 | Form 3 [14-12-2016(online)].pdf | 2016-12-14 |
| 27 | 201647042606-IntimationOfGrant30-04-2019.pdf | 2019-04-30 |
| 28 | Form 5 [14-12-2016(online)].pdf | 2016-12-14 |
| 28 | 201647042606-RELEVANT DOCUMENTS [16-03-2020(online)].pdf | 2020-03-16 |
| 1 | 201647042606SS_25-10-2018.pdf |