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Substituted Pyrrolidinones As Inhibitors Of 11 Beta Hydroxysteroid Dehydrogenase 1
Abstract: The present invention discloses novel compounds of Formula I: ( I ) possessing 11β -HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11 β -HSD type 1 activity.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
01 October 2008
Publication Number
46/2008
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2012-01-11
Renewal Date
Applicants
ELI LILLY AND COMPANY
LILLY CORPORATE CENTER, CITY OF INDIANAPOLIS, STATE OF INDIANA 46285,
Inventors
1. ALLEN, JOHN, GORDON
5255 Via Capote Newbury Park California 91320 United States of America.
2. KRASUTSKY, ALEXEI, PAVLOVYCH
6787 Woodcliff Circle Zionsville Indiana 46077 United States of America.
3. WALLACE, OWEN, BRENDAN
13297 Mink Lane Westfield Indiana 46074 United States of America.
4. XU, YANPING
6676 Pennan Court Noblesville Indiana 46062 United States of America.
5. YORK, JEREMY, SCHULENBURG
16095 Tenor Way Noblesville Indiana 46060 United States of America.
Specification
PLEASE SEE THE SPECIFICATION ATTACHED.
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 2107-mumnp-2008 form 13 (3-10-2008).pdf | 2018-08-09 |
| 1 | 2107-MUMNP-2008-FORM 3(16-10-2008).pdf | 2008-10-16 |
| 2 | 2107-mumnp-2008-abstract(1-10-2008).pdf | 2018-08-09 |
| 2 | 2107-MUMNP-2008-CORRESPONDENCE(16-10-2008).pdf | 2008-10-16 |
| 3 | Form-5.doc | 2018-08-09 |
| 3 | 2107-MUMNP-2008-ASSIGNMENT(31-5-2011).pdf | 2018-08-09 |
| 4 | 2107-mumnp-2008-claims(1-10-2008).pdf | 2018-08-09 |
| 5 | Form-1.pdf | 2018-08-09 |
| 5 | 2107-MUMNP-2008-CLAIMS(AMENDED)-(13-5-2011).pdf | 2018-08-09 |
| 6 | abstract1.jpg | 2018-08-09 |
| 6 | 2107-MUMNP-2008-CLAIMS(AMENDED)-(3-10-2008).pdf | 2018-08-09 |
| 7 | 2107-MUMNP2008-PETITION UNDER RULE 137(31-5-2011).pdf | 2018-08-09 |
| 7 | 2107-MUMNP-2008-CLAIMS(MARKED COPY)-(13-5-2011).pdf | 2018-08-09 |
| 8 | 2107-MUMNP2008-PETITION UNDER RULE 137(31-5-2011)-.pdf | 2018-08-09 |
| 8 | 2107-MUMNP-2008-CLAIMS(PCT)-(3-10-2008).pdf | 2018-08-09 |
| 9 | 2107-MUMNP-2008-CORRESPONDENCE(1-12-2008).pdf | 2018-08-09 |
| 9 | 2107-MUMNP-2008_EXAMREPORT.pdf | 2018-08-09 |
| 10 | 2107-MUMNP-2008-CORRESPONDENCE(12-4-2013).pdf | 2018-08-09 |
| 10 | 2107-MUMNP-2008-US & EP PATENT(13-5-2011).pdf | 2018-08-09 |
| 11 | 2107-MUMNP-2008-CORRESPONDENCE(3-10-2008).pdf | 2018-08-09 |
| 11 | 2107-MUMNP-2008-REPLY TO EXAMINATION REPORT(13-5-2011).pdf | 2018-08-09 |
| 12 | 2107-MUMNP-2008-CORRESPONDENCE(31-5-2011).pdf | 2018-08-09 |
| 12 | 2107-MUMNP-2008-PCT-OTHER(1-12-2008).pdf | 2018-08-09 |
| 13 | 2107-mumnp-2008-description(complete)-(1-10-2008).pdf | 2018-08-09 |
| 13 | 2107-MUMNP-2008-PCT-ISA-237(1-12-2008).pdf | 2018-08-09 |
| 14 | 2107-mumnp-2008-form 1(1-10-2008).pdf | 2018-08-09 |
| 14 | 2107-MUMNP-2008-PCT-IB-373(1-12-2008).pdf | 2018-08-09 |
| 15 | 2107-mumnp-2008-form 13(3-10-2008).pdf | 2018-08-09 |
| 15 | 2107-MUMNP-2008-FORM 3(31-5-2011).pdf | 2018-08-09 |
| 16 | 2107-MUMNP-2008-FORM 26(13-5-2011).pdf | 2018-08-09 |
| 16 | 2107-MUMNP-2008-FORM 18(3-10-2008).pdf | 2018-08-09 |
| 17 | 2107-mumnp-2008-form 2(title page)-(1-10-2008).pdf | 2018-08-09 |
| 17 | 2107-mumnp-2008-form 2(1-10-2008).pdf | 2018-08-09 |
| 18 | 2107-mumnp-2008-form 2(1-10-2008).pdf | 2018-08-09 |
| 18 | 2107-mumnp-2008-form 2(title page)-(1-10-2008).pdf | 2018-08-09 |
| 19 | 2107-MUMNP-2008-FORM 18(3-10-2008).pdf | 2018-08-09 |
| 19 | 2107-MUMNP-2008-FORM 26(13-5-2011).pdf | 2018-08-09 |
| 20 | 2107-mumnp-2008-form 13(3-10-2008).pdf | 2018-08-09 |
| 20 | 2107-MUMNP-2008-FORM 3(31-5-2011).pdf | 2018-08-09 |
| 21 | 2107-mumnp-2008-form 1(1-10-2008).pdf | 2018-08-09 |
| 21 | 2107-MUMNP-2008-PCT-IB-373(1-12-2008).pdf | 2018-08-09 |
| 22 | 2107-mumnp-2008-description(complete)-(1-10-2008).pdf | 2018-08-09 |
| 22 | 2107-MUMNP-2008-PCT-ISA-237(1-12-2008).pdf | 2018-08-09 |
| 23 | 2107-MUMNP-2008-CORRESPONDENCE(31-5-2011).pdf | 2018-08-09 |
| 23 | 2107-MUMNP-2008-PCT-OTHER(1-12-2008).pdf | 2018-08-09 |
| 24 | 2107-MUMNP-2008-CORRESPONDENCE(3-10-2008).pdf | 2018-08-09 |
| 24 | 2107-MUMNP-2008-REPLY TO EXAMINATION REPORT(13-5-2011).pdf | 2018-08-09 |
| 25 | 2107-MUMNP-2008-CORRESPONDENCE(12-4-2013).pdf | 2018-08-09 |
| 25 | 2107-MUMNP-2008-US & EP PATENT(13-5-2011).pdf | 2018-08-09 |
| 26 | 2107-MUMNP-2008-CORRESPONDENCE(1-12-2008).pdf | 2018-08-09 |
| 26 | 2107-MUMNP-2008_EXAMREPORT.pdf | 2018-08-09 |
| 27 | 2107-MUMNP-2008-CLAIMS(PCT)-(3-10-2008).pdf | 2018-08-09 |
| 27 | 2107-MUMNP2008-PETITION UNDER RULE 137(31-5-2011)-.pdf | 2018-08-09 |
| 28 | 2107-MUMNP-2008-CLAIMS(MARKED COPY)-(13-5-2011).pdf | 2018-08-09 |
| 28 | 2107-MUMNP2008-PETITION UNDER RULE 137(31-5-2011).pdf | 2018-08-09 |
| 29 | 2107-MUMNP-2008-CLAIMS(AMENDED)-(3-10-2008).pdf | 2018-08-09 |
| 29 | abstract1.jpg | 2018-08-09 |
| 30 | Form-1.pdf | 2018-08-09 |
| 30 | 2107-MUMNP-2008-CLAIMS(AMENDED)-(13-5-2011).pdf | 2018-08-09 |
| 31 | 2107-mumnp-2008-claims(1-10-2008).pdf | 2018-08-09 |
| 32 | 2107-MUMNP-2008-ASSIGNMENT(31-5-2011).pdf | 2018-08-09 |
| 33 | 2107-MUMNP-2008-CORRESPONDENCE(16-10-2008).pdf | 2008-10-16 |
| 33 | 2107-mumnp-2008-abstract(1-10-2008).pdf | 2018-08-09 |
| 34 | 2107-MUMNP-2008-FORM 3(16-10-2008).pdf | 2008-10-16 |
| 34 | 2107-mumnp-2008 form 13 (3-10-2008).pdf | 2018-08-09 |