The present invention relates to synergistic agrochemical combination comprising herbicide(s) and mixture thereof; and plant health additives for reducing phytotoxicity in crops on post herbicidal application. More particularly, the present invention relates to a herbicidal composition for weeds control in post emergence conditions comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof; and (C) a plant health additive(s) for reducing phytotoxicity in crops followed by application of a herbicide or mixture thereof. The present invention further relates to process of preparing said composition along with at least one inactive excipients and formulation thereof.
BACKGROUND OF THE INVENTION:
Weeds are a nuisance in most agricultural crops, orchards, plantation crops, landscapes and sometimes the herbicides used to control the weeds end up injuring crops, useful plants, some of ornamental plants. Herbicide injury is observed after application of herbicide in terms of stunting, yellowing, scorching, epinasty, hyponasty, germination loss, poor plant population stand in field and even loss of crop or plant yield. It normally happens while not following the directions on the label as carefully as one should. Farmers tend to use more herbicide than the label instructs or can be careless and spray during windy conditions or wave the wand around so that the spray drifts onto non-target plants.
Herbicides are pesticides useful for killing or controlling unwanted plants. Generally, there are two kinds of herbicides- selective and non-selective. Selective herbicides kill certain target weeds while leaving the desired crop relatively unharmed while non-selective herbicides kill both the weeds and crops. Profitable crop production depends on effective weed control. The weeds can reduce field crop yields by competing for water, sunlight and nutrients. In today’s crop production systems, starting off with a good burn-down program is a must as it helps to achieve maximum initial crop growth and reduce weed interference during early stages of the crop cycle. Since the weed-crop competition is critical during the early stages of crop cycle, the weed interference at early stage has a direct impact on the yield of the crop.
The term for plant damage is “phytotoxicity” and it can be caused by pesticides,
nutrients, or physical and environmental damage (wind, sun, hail, etc.). Often the
identity of the herbicide can be determined by the injury symptoms on the plants.
Symptoms can be divided into 5 main categories: leaf and shoot malformations,
root and shoot stunting, leaf spotting, leaf chlorosis (yellowing), and leaf necrosis
(death).
An effective weed control can be achieved by usage of herbicides appropriately. The activity of herbicides can be enhanced in various ways to achieve the maximum benefit. One of the ways is to use combinations. However, identifying appropriate combinations, which will reduce the toxicity at the same time due to the application of herbicides on crop, their agrochemical application rates and ratio of the combinations is essential to achieve efficacious control, which is not straight forward. The selection of a particular formulation type is more cumbersome for an agrochemical combination.
The efficacy of these herbicides against harmful weeds in the crop plants depends on the application rate, the formulation ingredients, the harmful weeds to be controlled, the climatic conditions and the soil conditions.
Farmers are applying more than one active ingredients or applying high use rate to control different types of weeds at a time, to control multiple generations of weeds in fields, to control troublesome weeds and to get residual control. Such practices increases the chances of herbicidal injury or phytotoxicity to the target crops.
There are many herbicides which used in combination creates characteristic phytotoxic injuries in plants like malformed, distorted leaves and shoots, stunted shoots and roots, chlorotic, necrotic, or spotted leaves.
However, there remains a great need for improved broadleaf and grassy weed control compositions and a method of controlling such noxious vegetation in pre and post emergence without adversely affecting desirable plants and which reduces the amount of chemical herbicidal agent necessary to obtain the acceptable weed control along with reducing the undesirable post treatment toxic effect or injury of the herbicides on crops.
There are many combinations of herbicides known in the art for the control of weeds. For example, CN103636647A relates to agricultural insecticide composition, a kind of composition that contains benzene azoles humulone and rimsulfuron specifically, is that to take benzene azoles humulone and rimsulfuron be active ingredient, for control of maize field annual weed.
US20180368400A1 relates to a synergistic herbicidal composition and a method of controlling the growth of undesirable plants. A synergistic herbicidal composition comprising Pyroxasulfone, Topramezone and Atrazine as the active components, wherein the weight ratio of Pyroxasulfone, Topramezone and Atrazine ranges from 1 to 10:1 to 10:1 to 100, is provided. Use of the synergistic herbicidal composition for controlling the growth of undesirable plants is also provided. A method of controlling the growth of undesirable plants, which comprises applying the active components Pyroxasulfone, Topramezone and Atrazine of the synergistic herbicidal composition to the undesirable plants or their growing locus or separately is also provided.
AU2010334815B2 to nucleic acid sequences encoding a hydroxyl phenyl pyruvate dioxygenase (EC 1.13.11.27, abbreviated herein as HPPD) obtained from bacteria belonging to the genus Kordia, as well as the proteins encoded thereby, and to a chimeric gene which comprises such nucleic acid sequence, and to the use of such nucleic acid sequences, proteins or chimeric genes for obtaining plants which are tolerant to HPPD inhibitor herbicides. The patent further claims herbicides Topramezone, Bicyclopyrone along with other group of herbicides.
There is however a need for improvement of these combinations. Further there is a need of a safener in the herbicidal composition which will reduce the unwanted phytotoxic effect on crops on post herbicidal application. Plant health additives play a significant role in development of crop and reduces the phytotoxic effect. Single active combinations used over a long period of time has resulted in resistance. With the onset of resistance to certain weeds, there is a need in the art for a combination of actives that decreases chances of resistance and improves the spectrum of controlling grassy, broad leaf weeds and sedges with pre-emergence and post-emergence application.
However still there is a need of herbicidal composition comprises of a herbicide Topramezone; a one or more herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof; and a plant health additive(s) for reducing phytotoxicity in crops followed by application of a herbicide or mixture thereof, which overcomes some of the existing problems and can be prepared easily without much complex manufacturing process.
In general use, the herbicidal actives are used in the form of a dilute aqueous composition because it can attain a good interaction with the target weed. However, most active herbicidal compounds that are used as pesticides are only sparingly or even insoluble in water. The low solubility of such compounds present the challenges and difficulties to formulator in formulating herbicidal compounds in stable formulations that can be easily stored for a long time and which still have a high stability and effective activity until end use. This problem especially occurs and may get worsen if more than one active compound is present in the composition.
Therefore, one object of the present invention is to provide improved herbicidal combination for weeds control in pre and post emergence conditions along with plant health additives acting as a safener in the herbicidal composition which will reduce the unwanted phytotoxic effect on post herbicidal application. Another object of the present invention is to provide a method and a composition for controlling weeds in pre and post emergence conditions.
Yet another object of the present invention is to provide improved combinations of improved broadleaf and grassy weed control without adversely affecting desirable plants and reducing the unwanted effect by using plant health additives.
Embodiment of the present invention can ameliorate one or more of the above mentioned problems.
Inventors of the present invention have surprisingly found that a herbicide Topramezone; a one or more herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof; and a plant health additive(s) for reducing phytotoxicity in crops followed by application of a herbicide or mixture thereof, as described herein which can provide solution to the above mentioned problems.
SUMMARY OF THE INVENTION
Therefore an aspect of the present invention provides a synergistic herbicidal composition comprising plant health additive(s) for reducing phytotoxicity in crops on post herbicidal application.
Another aspect of the present invention provides composition comprises with various compounds and micronutrients as a plant health additive along with herbicides for reducing phytotoxicity in crops on post herbicidal application.
Therefore an aspect of the present invention provides a synergistic herbicidal composition comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof; and (C) a plant health additive(s) for reducing phytotoxicity in crops followed by application of a herbicide or mixture thereof.
Further aspect of the present invention provides a synergistic herbicidal composition comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor, Synthetic Auxin, Inhibitor of photosynthesis at photosystem II site A, Inhibitor of photosynthesis at photosystem II site B, Inhibitor of 1-deoxy-D-xyulose 5-phosphate synthatase (DOXP synthase), Inhibitor of protoporphyrinogen oxidase (Protox, PPO), Mitosis Inhibitor, Inhibitor of 7,8-dihydro-preroate synthetase (DHP), Inhibitor of indole acetic acid transport, Inhibitor of cell wall synthesis site C, Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD), Tyrosine Aminotransferase, Inhibition of dihydroorotate dehydrogenase(DHODH), HTS (homogentisate solanesyl transferase)-a downstream enzyme of HPPD, VLCAFE inhibitors, Inhibition of Solanesyl Diphosphate Synthase (SDS), or Herbicide with unknown mode of action or mixture thereof; and (C) a plant health additive(s) for reducing phytotoxicity in crops followed by application of a herbicide or mixture thereof.
In present aspect of the invention to provide a synergistic herbicidal composition comprising plant heath additives as a safener in composition for reducing phytotoxicity in crops on post herbicidal application present in the present herbicidal composition.
In further aspect of the present invention provides a synergistic herbicidal composition comprising plant heath additives to promote speedy recovery of the crop or plant from herbicidal injury. Thus accordingly reduces the stress due to abiotic factors and thus promotes overall plant or crop health and there by plant or crop yield.
Accordingly, in a further aspect, the present invention to provide a combination and a method of controlling pre-emergence and post-emergence weeds and provide a herbicidal combination for improved broadleaf and grassy weed control without adversely affecting desirable plants by reducing phytotoxicity in crops on post herbicidal application present in the present herbicidal composition.
Yet another aspect, the present invention provides to provide a herbicidal combination which reduces the amount of chemical herbicidal agent necessary to obtain the acceptable weed control.
Accordingly, the present invention relates to method which provides a broader spectrum of controlling weeds that helps in resistance management, thus preventing the weed from becoming resistant to either of the herbicides while providing a broader spectrum of control at lower use rates.
As per one embodiment formulation for the herbicidal composition is selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Jambo balls or bags (bags in water soluble pouch), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion (SE), Soluble concentrate (SL), Water dispersible granule (WG or WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), A mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), Controlled release granules (CR); and and one or more customary formulation adjuvants such as a) dispersant b) wetting agent c) anti-foaming agent d) biocides e) anti-freezing agent f) suspending agent g) thickener h) coating agent and i) buffering agent.
The remainder of the aqueous formulation is preferably wholly water but may comprise other materials, such as inorganic salts. The formulation is preferably, completely free from organic solvents.
Accordingly, in a first aspect, the present invention provides a synergistic herbicidal compositions comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor, Synthetic Auxin, Inhibitor of photosynthesis at photosystem II site A, Inhibitor of photosynthesis at photosystem II site B, Inhibitor of 1-deoxy-D-xyulose 5-phosphate synthatase (DOXP synthase), Inhibitor of protoporphyrinogen oxidase (Protox, PPO), Mitosis Inhibitor, Inhibitor of 7,8-dihydro-preroate synthetase (DHP), Inhibitor of indole acetic acid transport, Inhibitor of cell wall synthesis site C, Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD), Tyrosine Aminotransferase, Inhibition of dihydroorotate dehydrogenase(DHODH), HTS (homogentisate solanesyl transferase)-a downstream enzyme of HPPD, VLCAFE inhibitors, Inhibition of Solanesyl Diphosphate Synthase (SDS), or Herbicide with unknown mode of action or mixture thereof; and (C) a plant health additive(s) for reducing phytotoxicity in crops followed by application of a herbicide or mixture thereof and one or more customary formulation adjuvants; shows synergistic activity.

DETAILED DESCRIPTION OF THE INVENTION:

The term "synergistic", as used herein, refers the combined action of two or more active agents blended together and administered conjointly that is greater than the sum of their individual effects.
"Bioactive amounts” as mentioned herein means that amount which, when applied treatment of crops, is sufficient to effect such treatment.
For the purposes of the present invention, plant health additive is used as ‘safener’ and the term ‘safener’ in present context is defined as substances which reduce or prevent the phytotoxic effect of crop protectants specifically herbicide, on plants treated therewith and/or on plants whose seeds and/or growth substrate have been treated or are treated therewith.
The term ‘herbicide’ is used herein to mean an active ingredient that kills, controls or otherwise adversely modifies the growth of unwanted plants. An herbicidally effective or vegetation controlling amount is an amount of active ingredient which causes an adversely modifying effect and includes deviations from natural development, killing, regulation, desiccation, retardation, and the like.
The term “phytotoxicity” as used herein means unintended herbicidal effect on a plant of interest resulting in significant damage to the plant. In an embodiment the present invention relates to use of a pyrethroid insecticide for reducing phytotoxicity in crops on post herbicidal application.
Therefore an aspect of the present invention provides a synergistic herbicidal composition comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof; and (C) a plant health additive(s) for reducing phytotoxicity in crops followed by application of a herbicide or mixture thereof.
Further aspect of the present invention provides a synergistic herbicidal composition comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor, Synthetic Auxin, Inhibitor of photosynthesis at photosystem II site A, Inhibitor of photosynthesis at photosystem II site B, Inhibitor of 1-deoxy-D-xyulose 5-phosphate synthatase (DOXP synthase), Inhibitor of protoporphyrinogen oxidase (Protox, PPO), Mitosis Inhibitor, Inhibitor of 7,8-dihydro-preroate synthetase (DHP), Inhibitor of indole acetic acid transport, Inhibitor of cell wall synthesis site C, Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD), Tyrosine Aminotransferase, Inhibition of dihydroorotate dehydrogenase(DHODH), HTS (homogentisate solanesyltransferase)-a downstream enzyme of HPPD, VLCAFE inhibitors, Inhibition of Solanesyl Diphosphate Synthase (SDS), or Herbicide with unknown mode of action or mixture thereof; and (C) a plant health additive(s) for reducing phytotoxicity in crops followed by application of a herbicide or mixture thereof.
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In an embodiment of the present invention herbicide of Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor from Sulfonylurea group is selected from chlorimuron ethyl, flazasulfuron, halosulfuron methyl, metsulfuron mehtyl, nicosufulfuron, primisulfuron methyl, pyrazosulfuron ehtyl, rimsulfuron, thifensulfuron-methyl, tribenuron methyl.
In an embodiment of the present invention herbicide from Acetoacetate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor from Pyrimidinyl(thio)benzoate group is pyrithiobac sodium; from Triazolopyrimidine group selected from diclosulam, florasulam, flumetsulam,
In an embodiment of the present invention herbicide from Acetoacetate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor of Sulfonylaminocarbonyl group is selected from thiencarbazone-methyl; from Imidazolinone group such as imazamox, imazapic, imazapyr, imazaquin, imazethapyr; from Sulfonanilides group is triafamone.
In an embodiment of the present invention herbicide from Synthetic Auxin of Phenoxy carboxylic acid group is selected from 2,4-D, MCPA, MCPB; of Pyridine carboxylic acid group is selected from aminopyralid, clopyralid, florpyrauxifen benzyl, fluroxypyr, picloram, triclopyr; of Benzoic acid group is dicamba; of Quinoline carboxylic acid group is quinclorac; and halauxifen methyl.
In an embodiment of the present invention herbicide from Inhibitor of photosynthesis at photosystem II site A of Triazine group is selected from ametryn, atrazine, simazine; of Triazinone group is selected from hexazione, metamitron, metribuzin.
In an embodiment of the present invention herbicide from Inhibitor of photosynthesis at photosystem II site B of Benzothiadiazinone group is bentazone; of Nitrile group is selected from bromoxynil, ioxynil; of Phenyl-pyridazine group is pyridate.
In an embodiment of the present invention herbicide from Inhibitor of 1-deoxy-D-xyulose 5-phosphate synthatase (DOXP synthase) of Isoxazolidinone group is clomazone.
In an embodiment of the present invention herbicide from Inhibitor of protoporphyrinogen oxidase (Protox, PPO) of Dipheylether group is selected from aclifluorfen, bifenox, fluoroglycofen, fomesafen, lactofen, oxyfluorfen; of Triazolinone group is selected from azafenidin, carfentrazone-ethyl, flufenpyr-ethyl, sulfentrazone; of Pyrimidinedione group is selected from butafenacil, saflufenacil; of N-phenylphthalimide group is selected from flumiclorac, flumioxazin; of N-Phenyl-imide group is trifludimoxazin; of Thiadiazole group is fluthiacet-methyl; of Oxadiazole group is selected from oxadiargyl, oxadiazon; of Phenylpyrazole group is pyraflufen-ethyl, of other group is pyraclonil; of Uracil group is tiafenacil; of Pyrazole group is cyclopyranil.
In an embodiment of the present invention herbicide from Mitosis Inhibitor of Chloroacetamide group is selected from acetochlor, alachlor, butachlor, dimethenamid, metazachlor, pretilachlor, propachlor, S-metolachlor; of Tetrazolinone group is fentrazamide; of Oxyacetamide group is selected from flufenacet, mefenacet; of Acetamide group is napropamide; of Carbamate group is carbetamide.
In an embodiment of the present invention herbicide from Inhibitor of 7,8-dihydro-preroate synthetase (DHP) of Carbamate group is asulam.
In an embodiment of the present invention herbicide from Inhibitor of indole acetic acid transport of Phthalamate semicarbazone group is selected from diflufenzopyr, naptalam.
In an embodiment of the present invention herbicide from Inhibitor of cell wall synthesis site C of Alkylazines group is selected from indaziflam, triaziflam.
In an embodiment of the present invention herbicide from Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD) of Pyrazole group is selected from benzofenap, pyrasulfotole, pyrazolynate, pyrazoxyfen, tolpyralate; of Benzoylbicyclooctanedione group is benzobicyclon; Triketone group is selected from mesotrione, tembotrione, sulcotrione, tefuryltrione, fenquinotrione, lancotrione sodium; of Isoxazoles group is selected from isoxaflutole; bicyclo ring compound group is bicyclopyrone.
In an embodiment of the present invention herbicide from Inhibitors of dihydroorotate dehydrogenase (DHODH) is tetflupyrolimet.
In an embodiment of the present invention herbicide from HTS (homogentisate solanesyltransferase)-a downstream enzyme of HPPD is cyclopyrimorate.
In an embodiment of the present invention herbicide from VLCAFE inhibitors of Isoxazoline group is pyroxasulfone, of Triazolinone group is ipfencarbazone, of Trifluoromethansulfonanilides group is dimesulfazet, and other compounds such as fenoxasulfone.
In an embodiment of the present invention herbicide from Inhibitors of Solanesyl Diphosphate Synthase (SDS) is aclonifen.
In an embodiment of the present invention herbicide with unknown mode of action is selected from diphenamid, naproanilide, napropamide, cacodylic acid, epyrifenacil, bixzolone.
In an embodiment of the present invention Plant health additive for reducing phytotoxicity in crops on post herbicidal application is selected from humic acid (salts), fulvic acid (salts), amino acids (alanine, arginine, aspartic acid, cysteine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine or mixture thereof), protein hydrolysates, peptides, organic acid, acetylthioproline, thiazolidine carboxylic acid, jasmonic acid, methyl jasmonate, chitosan, chitin, seaweed extract (Ascophyllum nodosum), polyamines, silicic acid (salts)-orthosilicic acid (H4Si04), silica nanoparticles (10-100 nm), calcium silicate, potassium silicate, sodium silicate), silicyclic acid, lactic acid, phenyllactic acid, fumaric acid, acibenzolar-s-methyl, gibberellic acid, GA3, brassinolide, forchlorfenuron, triacontanol, silicyclic acid, Nitrophenolate (sodium para-nitrophenolate, ortho-nitrophenolate, sodium-5-nitroguaiacolate), nitrobenzene or mixture thereof.
In an embodiment of the present invention plant health additive for reducing phytotoxicity in crops on post herbicidal application from group of micronutrients is selected from Zinc (zinc sulphate heptahydrate ZnSO47H2O, zinc sulphate mono hydrate ZnSO4.H2O, chelated zinc as Zn-EDTA, zinc oxide, Zinc Lactate Gluconate, Zinc Polyflavonoid), Boron (borax-sodium tetraborate, boric acid (H3BO3), di-sodium octa borate tetra hydrate (Na2B8O13.4H2O), di-sodium tetra borate penta hydrate, anhydrous borax, ), Manganese (manganese sulphate), Copper (copper sulphate), Iron (ferrous sulphate, chelated iron as Fe-EDTA), Molybdanum (ammonium molybdate), Magnesium (Magnesium sulphate) or Sulphur (elemental sulphur, boronated sulphur) and mixture thereof.
Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor:
Sulfonylurea:
Halosulfuron methyl is a herbicide used on maize, sugarcane and ric. It has IUPAC name as methyl-3-chloro-5-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoyl]-1-methyl pyrazole-4-carboxylate.
Nicosufulfuron is a N-sulfonylurea that is 2-(carbamoylsulfamoyl)-N,N-dimethylpyridine-3-carboxamide substituted by a 4,6-dimethoxypyrimidin-2-yl group at the amino nitrogen. It has a role as an environmental contaminant, a xenobiotic and a herbicide. It is a member of pyridines, a N-sulfonylurea and a member of pyrimidines. It has IUPAC name as 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoyl]-N,N-dimethylpyridine-3-carboxamide.
Primisulfuron methyl is belongs to the class of sulfonylurea herbicides. It has IUPAC name as methyl 2-[[4,6-bis(difluoromethoxy)pyrimidin-2-yl]carbamoyl sulfamoyl] benzoate.
Rimsulfuron is a N-sulfonylurea that is N-carbamoyl-3-(ethylsulfonyl) pyridine-2-sulfonamide substituted by a 4,6-dimethoxypyrimidin-2-yl group at the amino nitrogen atom. It has a role as an environmental contaminant, a xenobiotic and a herbicide. It is a member of pyridines, a N-sulfonylurea, a member of pyrimidines, a sulfone and an aromatic ether. It has IUPAC name as 1-(4,6-dimethoxypyrimidin-2-yl)-3-(3-ethylsulfonylpyridin-2-yl)sulfonylurea. It blocks branched-chain amino acid synthesis by inhibiting the plant enzyme, acetolactate synthase.
Thifensulfuron-methyl is a methyl ester resulting from the formal condensation of the carboxy group of thifensulfuron with methanol. It is used as a post-emergence herbicide for the control of grass and broad-leaved weeds. It has a role as an environmental contaminant, a xenobiotic, a herbicide and an agrochemical. It is a N-sulfonylurea, a member of thiophenes, a member of 1,3,5-triazines and a methyl ester. It derives from a thifensulfuron. It has IUPAC name as methyl 3-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoylsulfamoyl]thiophene-2-carboxylate.
Triazolopyrimidine:
Flumetsulam is a sulfonamide. It has IUPAC name as N-(2,6-difluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide. It inhibits of acetolactate synthase ALS (acetohydroxyacid synthase AHAS).
Sulfonylaminocarbonyl:
Thiencarbazone-methyl is an N-sulfonylurea in which the sulfur atom is attached to a 4-(methoxycarbonyl)-2-methylthiophen-3-yl group and in which the non-sulfonated nitrogen is substituted by a 3-methoxy-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl group. It is a herbicide used for the selective control of grasses and broadleaf weeds primarily in corn. It has a role as an EC 2.2.1.6 (acetolactate synthase) inhibitor, a herbicide and an agrochemical. It is a member of thiophenes, a methyl ester, a member of triazoles, a N-sulfonylurea and an ether. It derives from a thiencarbazone. It has IUPAC name as methyl 4-[(3-methoxy-4-methyl-5-oxo-1,2,4-triazole-1-carbonyl)sulfamoyl]-5-methylthiophene-3-carboxylate.
Synthetic Auxin:
Phenoxy carboxylic acid:
2, 4-D is a member of the phenoxy family of herbicides, which include:; 2, 4-D is a synthetic auxin, which is a class of plant hormones. It is absorbed through the leaves and is translocated to the meristems of the plant. Uncontrolled, unsustainable growth ensues, causing stem curl-over, leaf withering, and eventual plant death. 2, 4-D is typically applied as an amine salt, but more potent ester versions exist as well. 2, 4-Dichlorophenoxyacetic acid (usually referred to by its abbreviation, 2, 4-D) is a common systemic pesticide/herbicide used in the control of broadleaf weeds. It is one of the most widely used herbicide in the world, and the third most commonly used in North America. 2, 4-D is a synthetic auxin (plant hormone), and as such it is often used in laboratories for plant research and as a supplement in plant cell culture media such as MS medium. It was a major ingredient in Agent Orange alongside its chemically similar relative, 2, 4, 5-T (2, 4, 5-trichlorophenoxyacetic acid).
Pyridine carboxylic acid:
Clopyralid is an organochlorine pesticide having a 3,6-dichlorinated picolinic acid structure. It has a role as a herbicide. It is a member of pyridines and an organochlorine pesticide. It derives from a picolinic acid. It has IUPAC name as 3,6-dichloropyridine-2-carboxylic acid. It acts as a Selective systemic herbicide, absorbed by the leaves and roots, with translocation both acropetally and basipetally, and accumulation in meristematic tissue. Exhibits an auxin type reaction. Acts on cell elongation and respiration.
Fluroxypyr is an aminopyridine that is pyridin-4-amine substituted by chloro groups at positions 3 and 5, a fluoro group at position 6 and a carboxymethoxy group at position 2. It has a role as a xenobiotic, an environmental contaminant and a herbicide. It is an aminopyridine, an organochlorine compound, an aromatic ether, a monocarboxylic acid and an organofluorine compound. It has IUPAC name as 2-(4-amino-3,5-dichloro-6-fluoropyridin-2-yl)oxyacetic acid
Benzoic acid:
Dicamba is a white solid dissolved in a liquid carrier. The carrier is water emulsifiable. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Since it is a liquid it can easily penetrate the soil and contaminate groundwater and nearby streams. It can cause illness by inhalation, skin absorption and/or ingestion. It is used as a herbicide. It has IUPAC name as 3,6-dichloro-2-methoxybenzoic acid. In plants, dicamba mimics auxin plant growth hormones and causes uncontrolled growth. This hormonal mode of action is specific to plants and does not affect animals.
Inhibitor of photosynthesis at photosystem II site A:
Triazine:
Atrazine is an herbicide that does not occur naturally. Pure atrazine is an odorless, white powder that is not very volatile, reactive, or flammable and that will dissolve in water. Atrazine is used to kill weeds, primarily on farms, but has also been used on highway and railroad rights-of-way. The EPA now restricts how atrazine can be used and applied; only trained people are allowed to spray it.
Triazinone:
Metribuzin is a member of the class of 1,2,4-triazines that is 1,2,4-triazin-5(4H)-one substituted by an amino group at position 4, tert-butyl group at position 6 and a methylsulfanyl group at position 3. It has a role as a xenobiotic, an environmental contaminant, a herbicide and an agrochemical. It is a member of 1,2,4-triazines, an organic sulfide and a cyclic ketone. It has an IUPAC name as 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one. It acts as a photosynthesis inhibitor.
Inhibitor of protoporphyrinogen oxidase (Protox, PPO):
Triazolinone:
Carfentrazone-ethyl, is a Ethyl 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-4-fluorophenyl}propanoate is an ethyl ester resulting from the formal condensation of the carboxy group of 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-4-fluorophenyl} propanoic acid with ethanol. It has a role as a proherbicide.
Pyrimidinedione:
Saflufenacil is a member of the class of sulfamides that is sulfamide in which one of the amino groups has been substituted by a methyl group an an isopropyl group, while the other has been substituted by a 2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]benzoyl group. An important BASF herbicide, not registered in Europe but sold in USA, Canada and several other countries to control weeds in a wide range of food crops. Often mixed with other products such as glyphosate. It has a role as an EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor, a herbicide and an agrochemical. It is a member of monochlorobenzenes, a member of monofluorobenzenes and a member of sulfamides. It derives from a uracil.

N-phenylphthalimide:
Flumioxazin is a benzoxazine that is N-(prop-2-yn-1-yl)-2H-1,4-benzoxazin-3(4H)-one which is substituted at position 6 by a 1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl group and at position 7 by a fluorine. A protoporphyrinogen oxidase inhibitor, it is used for the control of weeds in soya, peanuts, and a variety of vegetable and fruit crops. It has a role as a herbicide, an agrochemical, an EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor and a teratogenic agent. It is a benzoxazine, a terminal acetylenic compound, a dicarboximide and an organofluorine compound. It has IUPAC name as 2-(7-fluoro-3-oxo-4-prop-2-ynyl-1,4-benzoxazin-6-yl)-4,5,6,7-tetrahydroisoindole-1,3-dione.
N-Phenyl-imide:
Trifludimoxazin is a member of the class of 1,3,5-triazinanes that is 6-sulfanylidene-1,3,5-triazinane-2,4-dione in which the hydrogens attached to the nitrogens adjacent to the thioxo group have been replace by methyl groups and in which the hydrogen attached to the remaining nitrogen has replaced by a 2,2,7-trifluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-1,4-benzoxazin-6-yl group. A protoporphyrinogen oxidase inhibitor, it is used as a herbicide. It has a role as a herbicide, an EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor and an agrochemical. It is a benzoxazine, a member of 1,3,5-triazinanes and an organofluorine compound. It has IUPAC name as 1,5-dimethyl-6-sulfanylidene-3-(2,2,7-trifluoro-3-oxo-4-prop-2-ynyl-1,4-benzoxazin-6-yl)-1,3,5-triazinane-2,4-dione.
Thiadiazole:
Fluthiacet-methyl is a methyl ester resulting from the formal condensation of the carboxy group of fluthiacet with methanol. A proherbicide for fluthiacet, it is used for the control of broad-leaved weeds in crops such as maize and soya. It has a role as an agrochemical, an EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor and a proherbicide. It is an organic sulfide, a methyl ester, a member of monochlorobenzenes, a member of monofluorobenzenes and a thiadiazolopyridazine. It derives from a fluthiacet. It has IUPAC name as methyl 2-[2-chloro-4-fluoro-5-[(3-oxo-5,6,7,8-tetrahydro-[1,3,4]thiadiazolo[3,4-a]pyridazin-1-ylidene)amino]phenyl]sulfanylacetate.
Mitosis Inhibitor:
Chloroacetamide:
Acetochlor is a monocarboxylic acid amide that is N-phenylacetamide carrying an ethyl and a methyl group at positions 2 and 6 respectively on the benzene ring while one of the methyl hydrogens as well as the hydrogen attached to the nitrogen atom have been replaced by a chloro and an ethoxymethyl group respectively. It has a role as a herbicide, a xenobiotic and an environmental contaminant. It is a monocarboxylic acid amide, an organochlorine compound and an aromatic amide. It derives from a N-phenylacetamide. It has IUPAC name as 2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methylphenyl)acetamide.
Dimethenamid is a 2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-(1-methoxypropan-2-yl) acetamide is an organochlorine compound that is 2-chloroacetamide substituted by a 2,4-dimethylthiophen-3-yl and a 1-methoxypropan-2-yl group at the nitrogen atom. It is a member of thiophenes, an aromatic amide, an ether and an organochlorine compound. It has IUPAC name as 2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-(1-methoxypropan-2-yl) acetamide.
S-metolachlor is the (S)-enantiomer of 2-chloro-N-(2-ethyl-6-methylphenyl)-N-(1-methoxypropan-2-yl)acetamide. It is an enantiomer of a (R)-metolachlor. It has IUPAC name as 2-chloro-N-(2-ethyl-6-methylphenyl)-N-[(2S)-1-methoxypropan-2-yl] acetamide.
Inhibitor of indoleacetic acid transport:
Phthalamate semicarbazone:
Diflufenzopyr is an auxin-transport inhibitor that can increase the phytotoxicity of certain auxin-mimicking herbicides such as dicamba on broadleaf species. It has IUPAC name as 2-[(E)-N-[(3,5-difluorophenyl)carbamoylamino]-C-methyl carbo nimidoyl]pyridine-3-carboxylic acid.
Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD):
Pyrazole:
Tolpyralate is 1-({1-ethyl-4-[3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl) benzoyl]-1H-pyrazol-5-yl}oxy)ethyl methyl carbonate, that is 1H-pyrazole substituted by an ethyl, 3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl, and 1-[(methoxycarbonyl) oxy] ethoxy groups at positions 1, 4 and 5, respectively. It is an aromatic ether, a benzoylpyrazole, a carbonate ester, a member of toluenes, an aromatic ketone and a sulfone.
Triketone:
Mesotrione is an aromatic ketone that is cyclohexa-1,3-dione in which one of the hydrogens at position 2 is substituted by a 4-(methanesulfonyl)-2-nitrobenzoyl group. It has a role as a herbicide, an EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor, a xenobiotic, an environmental contaminant and a carotenoid biosynthesis inhibitor. It is a sulfone, a C-nitro compound, an aromatic ketone and a beta-triketone. It derives from a benzophenone. It has IUPAC name as 2-(4-methylsulfonyl-2-nitrobenzoyl)cyclohexane-1,3-dione. Mechanistic studies show that the toxic effects of /mesotrione/ are largely attributable to increased plasma tyrosine levels following 4-hydroxyphenyl pyruvate dioxygenase (HPPD) inhibition. Tyrosine levels are increased to a greater extent in rats (particularly males) due to differences in the activity of enzymes in the tyrosine catabolic pathway.
Tembotrione is an aromatic ketone that is 2-benzoylcyclohexane-1,3-dione in which the phenyl group is substituted at positions 2, 3, and 4 by chlorine, (2,2,2-trifluoroethoxy)methyl, and methylsulfonyl groups, respectively. It is a post-emergence herbicide used (particularly in conjunction with the herbicide safener cyprosulfamide) for the control of a wide range of broad-leaved and grassy weeds in corn and other crops. It has a role as a herbicide, an agrochemical, an EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor and a carotenoid biosynthesis inhibitor. It is a sulfone, a cyclic ketone, an aromatic ketone, a member of monochlorobenzenes, an organofluorine compound, an ether and a beta-triketone. It has IUPAC name as 2-[2-chloro-4-methylsulfonyl-3-(2,2,2-trifluoroethoxymethyl) benzoyl]cyclohexane-1,3-dione. Tembotrione is a broad-spectrum early and mid-postemergence herbicide that belongs to the triketone class of herbicides. It acts by inhibiting 4-hydroxyphenylpyruvate dioxygenase (HPPD), which leads to chlorophyll destruction by photooxidation and causes bleaching of emerging foliar tissue. In mammals, HPPD is a key enzyme in the catabolism of tyrosine. It catalyzes the conversion of 4-hydroxyphenylpyruvate (HPP) to homogentisate. Inhibition of HPPD leads to a reconversion of HPP to tyrosine and a consequent increase in blood tyrosine concentrations (tyrosinemia).
Sulcotrione is an aromatic ketone that is cyclohexane-1,3-dione substituted by a 2-chloro-4-(methylsulfonyl)benzoyl group at position 2. It has a role as an environmental contaminant, a xenobiotic, a herbicide and a carotenoid biosynthesis inhibitor. It is an aromatic ketone, a sulfone, a member of cyclohexanones and a beta-triketone. It has IUPAC name as 2-(2-chloro-4-methylsulfonylbenzoyl)cyclohexane-1,3-dione.
Isoxazoles:
Isoxaflutole is a member of the class of isoxazoles that is 1,2-oxazole substituted by a 2-(methanesulfonyl)-4-(trifluoromethyl)benzoyl group and a cyclopropyl group at positions 4 and 5, respectively. It is a 4-hydroxyphenylpyruvate dioxygenase inhibitor which is used as a herbicide for weed control in maize and sugarcane. It has a role as an EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor, a proherbicide and an agrochemical. It is a member of cyclopropanes, a member of isoxazoles, an aromatic ketone, a member of (trifluoromethyl)benzenes and a sulfone. It has IUPAC name as (5-cyclopropyl-1,2-oxazol-4-yl)-[2-methylsulfonyl-4-(trifluoromethyl) phenyl]methanone.
Bicyclo ring compound:
Bicyclopyrone is a member of the class of pyridines that is pyridine which is substituted at positions 2, 3, and 6 by (2-methoxyethoxy)methyl, (2-hydroxy-4-oxobicyclo[3.2.1]oct-2-en-3-yl)carbonyl, and trifluoromethyl groups, respectively. It is a broad-spectrum herbicide developed by Syngenta and used for the pre- and post-emergence control of weeds in corn. It has a role as a herbicide, an agrochemical and a carotenoid biosynthesis inhibitor. It is a member of pyridines, an aromatic ketone, a carbobicyclic compound, a beta-diketone, an organofluorine compound, an ether, an enol and an enone. It has IUPAC name as (1R,5S)-3-[hydroxy-[2-(2-methoxyethoxymethyl)-6-(trifluoromethyl)pyridin-3 yl]methylidene] bicycle [3.2.1] octane-2,4-dione.
VLCAFE inhibitors:
Isoxazoline:
Pyroxasulfone is a Isoxazoline group of VLCFA inhibitors. It has IUPAC name as 3-[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl) pyrazol-4-yl]methylsulfonyl]-5,5-di methyl -4H-1,2-oxazole.
The present inventors believe that the combination of the present invention surprisingly results in a synergistic action. The combination of the present invention allows for a broad spectrum of weed control and hence has surprisingly improved plant vigour and yield. The broad spectrum of the present combination of controlling weeds that also provides a solution for in resistance management, thus preventing the weed from becoming resistant to either of the herbicides while providing a broader spectrum of control at lower use rates.
The synergistic composition has very advantageous curative, preventive herbicidal properties for protecting cultivated plants. As has been mentioned, said active ingredient composition can be used to inhibit or destroy and effective management of the controlling pre-emergence and post-emergence weeds. The synergistic composition comprising herbicidal compounds for management and control of broad-leaved weeds and grasses in crops of useful plants.
The present synergistic herbicidal composition further comprises of plant health additives play very crucial role in protection of plant or crops of interest. The plant health additives in present composition reduces the phytotoxicity of herbicides and promotes speedy recovery of the crop or plant from herbicidal injury. Thus accordingly reduces the stress due to abiotic factors and thus promotes overall plant or crop health and there by plant or crop yield.
Therefor the aspect of the present invention provides the herbicidal compositions comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof; and (C) a plant health additive(s) for reducing phytotoxicity in crops followed by application of a herbicide or mixture thereof; are present in most preferred composition as below:
Compound A Compound B Herbicide(s) Compound C Plant health additives as safener
Topramezone Halosulfuron methyl Fulvic acid
Topramezone Nicosulfuron Fulvic acid
Topramezone Rimsulfuron Fulvic acid
Topramezone 2,4-D Fulvic acid
Topramezone Clopyralid Fulvic acid
Topramezone Fluroxypyr Fulvic acid
Topramezone Halauxifen methyl Fulvic acid
Topramezone Atrazine Fulvic acid
Topramezone Metribuzin Fulvic acid
Topramezone Clomazone Fulvic acid
Topramezone Carfentrazone ethyl Fulvic acid
Topramezone S-metolachlor Fulvic acid
Topramezone Tolpyralate Fulvic acid
Topramezone Mesotrione Fulvic acid
Topramezone Tembotrione Fulvic acid
Topramezone Sulcotrione Fulvic acid
Topramezone Isoxaflutole Fulvic acid
Topramezone Bicyclopyrone Fulvic acid
Topramezone Pyroxasulfone Fulvic acid
Topramezone Halosulfuron methyl Amino acid
Topramezone Nicosulfuron Amino acid
Topramezone Rimsulfuron Amino acid
Topramezone 2,4-D Amino acid
Topramezone Clopyralid Amino acid
Topramezone Fluroxypyr Amino acid
Topramezone Halauxifen methyl Amino acid
Topramezone Atrazine Amino acid
Topramezone Metribuzin Amino acid
Topramezone Clomazone Amino acid
Topramezone Carfentrazone ethyl Amino acid
Topramezone S-metolachlor Amino acid
Topramezone Tolpyralate Amino acid
Topramezone Mesotrione Amino acid
Topramezone Tembotrione Amino acid
Topramezone Sulcotrione Amino acid
Topramezone Isoxaflutole Amino acid
Topramezone Bicyclopyrone Amino acid
Topramezone Pyroxasulfone Amino acid
Topramezone Halosulfuron methyl Seaweed extract
Topramezone Nicosulfuron Seaweed extract
Topramezone Rimsulfuron Seaweed extract
Topramezone 2,4-D Seaweed extract
Topramezone Clopyralid Seaweed extract
Topramezone Fluroxypyr Seaweed extract
Topramezone Halauxifen methyl Seaweed extract
Topramezone Atrazine Seaweed extract
Topramezone Metribuzin Seaweed extract
Topramezone Clomazone Seaweed extract
Topramezone Carfentrazone ethyl Seaweed extract
Topramezone S-metolachlor Seaweed extract
Topramezone Tolpyralate Seaweed extract
Topramezone Mesotrione Seaweed extract
Topramezone Tembotrione Seaweed extract
Topramezone Sulcotrione Seaweed extract
Topramezone Isoxaflutole Seaweed extract
Topramezone Bicyclopyrone Seaweed extract
Topramezone Pyroxasulfone Seaweed extract
Topramezone Halosulfuron methyl Brassinolide
Topramezone Nicosulfuron Brassinolide
Topramezone Rimsulfuron Brassinolide
Topramezone 2,4-D Brassinolide
Topramezone Clopyralid Brassinolide
Topramezone Fluroxypyr Brassinolide
Topramezone Halauxifen methyl Brassinolide
Topramezone Atrazine Brassinolide
Topramezone Metribuzin Brassinolide
Topramezone Clomazone Brassinolide
Topramezone Carfentrazone ethyl Brassinolide
Topramezone S-metolachlor Brassinolide
Topramezone Tolpyralate Brassinolide
Topramezone Mesotrione Brassinolide
Topramezone Tembotrione Brassinolide
Topramezone Sulcotrione Brassinolide
Topramezone Isoxaflutole Brassinolide
Topramezone Bicyclopyrone Brassinolide
Topramezone Pyroxasulfone Brassinolide
Topramezone Mesotrione+Atrazine Fulvic acid
Topramezone Mesotrione+Atrazine Amino acid
Topramezone Mesotrione+Atrazine Seaweed extract
Topramezone Mesotrione+Atrazine Brassinolide
Topramezone Mesotrione+Atrazine Silicic acid
Topramezone Mesotrione+Atrazine Nitrobenzene
Topramezone Mesotrione+Atrazine Gibberellic acid
Topramezone Mesotrione+Atrazine Triacontanol
Topramezone Tembotrione+Atrazine Fulvic acid
Topramezone Tembotrione+Atrazine Amino acid
Topramezone Tembotrione+Atrazine Seaweed extract
Topramezone Tembotrione+Atrazine Brassinolide
Topramezone Tembotrione+Atrazine Silicic acid
Topramezone Tembotrione+Atrazine Nitrobenzene
Topramezone Tembotrione+Atrazine Gibberellic acid
Topramezone Tembotrione+Atrazine Triacontanol
Topramezone Mesotrione+Tolpyralate Fulvic acid
Topramezone Mesotrione+Tolpyralate Amino acid
Topramezone Mesotrione+Tolpyralate Seaweed extract
Topramezone Mesotrione+Tolpyralate Brassinolide
Topramezone Mesotrione+Tolpyralate Silicic acid
Topramezone Mesotrione+Tolpyralate Nitrobenzene
Topramezone Mesotrione+Tolpyralate Gibberellic acid
Topramezone Mesotrione+Tolpyralate Triacontanol
Topramezone Tembotrione+Tolpyralate Fulvic acid
Topramezone Tembotrione+Tolpyralate Amino acid
Topramezone Tembotrione+Tolpyralate Seaweed extract
Topramezone Tembotrione+Tolpyralate Brassinolide
Topramezone Tembotrione+Tolpyralate Silicic acid
Topramezone Tembotrione+Tolpyralate Nitrobenzene
Topramezone Tembotrione+Tolpyralate Gibberellic acid
Topramezone Tembotrione+Tolpyralate Triacontanol
Topramezone 2,4-D+Halosulfuron methyl Fulvic acid
Topramezone 2,4-D+Halosulfuron methyl Amino acid
Topramezone 2,4-D+Halosulfuron methyl Seaweed extract
Topramezone 2,4-D+Halosulfuron methyl Brassinolide
Topramezone 2,4-D+Halosulfuron methyl Silicic acid
Topramezone 2,4-D+Halosulfuron methyl Nitrobenzene
Topramezone 2,4-D+Halosulfuron methyl Gibberellic acid
Topramezone 2,4-D+Halosulfuron methyl Triacontanol
Topramezone Halosulfuron methyl Silicic acid
Topramezone Nicosulfuron Silicic acid
Topramezone Rimsulfuron Silicic acid
Topramezone 2,4-D Silicic acid
Topramezone Clopyralid Silicic acid
Topramezone Fluroxypyr Silicic acid
Topramezone Halauxifen methyl Silicic acid
Topramezone Atrazine Silicic acid
Topramezone Metribuzin Silicic acid
Topramezone Clomazone Silicic acid
Topramezone Carfentrazone ethyl Silicic acid
Topramezone S-metolachlor Silicic acid
Topramezone Tolpyralate Silicic acid
Topramezone Mesotrione Silicic acid
Topramezone Tembotrione Silicic acid
Topramezone Sulcotrione Silicic acid
Topramezone Isoxaflutole Silicic acid
Topramezone Bicyclopyrone Silicic acid
Topramezone Pyroxasulfone Silicic acid
Topramezone Halosulfuron methyl Nitrobenzene
Topramezone Nicosulfuron Nitrobenzene
Topramezone Rimsulfuron Nitrobenzene
Topramezone 2,4-D Nitrobenzene
Topramezone Clopyralid Nitrobenzene
Topramezone Fluroxypyr Nitrobenzene
Topramezone Halauxifen methyl Nitrobenzene
Topramezone Atrazine Nitrobenzene
Topramezone Metribuzin Nitrobenzene
Topramezone Clomazone Nitrobenzene
Topramezone Carfentrazone ethyl Nitrobenzene
Topramezone S-metolachlor Nitrobenzene
Topramezone Tolpyralate Nitrobenzene
Topramezone Mesotrione Nitrobenzene
Topramezone Tembotrione Nitrobenzene
Topramezone Sulcotrione Nitrobenzene
Topramezone Isoxaflutole Nitrobenzene
Topramezone Bicyclopyrone Nitrobenzene
Topramezone Pyroxasulfone Nitrobenzene
Topramezone Halosulfuron methyl Gibberellic acid
Topramezone Nicosulfuron Gibberellic acid
Topramezone Rimsulfuron Gibberellic acid
Topramezone 2,4-D Gibberellic acid
Topramezone Clopyralid Gibberellic acid
Topramezone Fluroxypyr Gibberellic acid
Topramezone Halauxifen methyl Gibberellic acid
Topramezone Atrazine Gibberellic acid
Topramezone Metribuzin Gibberellic acid
Topramezone Clomazone Gibberellic acid
Topramezone Carfentrazone ethyl Gibberellic acid
Topramezone S-metolachlor Gibberellic acid
Topramezone Tolpyralate Gibberellic acid
Topramezone Mesotrione Gibberellic acid
Topramezone Tembotrione Gibberellic acid
Topramezone Sulcotrione Gibberellic acid
Topramezone Isoxaflutole Gibberellic acid
Topramezone Bicyclopyrone Gibberellic acid
Topramezone Pyroxasulfone Gibberellic acid
Topramezone Halosulfuron methyl Triacontanol
Topramezone Nicosulfuron Triacontanol
Topramezone Rimsulfuron Triacontanol
Topramezone 2,4-D Triacontanol
Topramezone Clopyralid Triacontanol
Topramezone Fluroxypyr Triacontanol
Topramezone Halauxifen methyl Triacontanol
Topramezone Atrazine Triacontanol
Topramezone Metribuzin Triacontanol
Topramezone Clomazone Triacontanol
Topramezone Carfentrazone ethyl Triacontanol
Topramezone S-metolachlor Triacontanol
Topramezone Tolpyralate Triacontanol
Topramezone Mesotrione Triacontanol
Topramezone Tembotrione Triacontanol
Topramezone Sulcotrione Triacontanol
Topramezone Isoxaflutole Triacontanol
Topramezone Bicyclopyrone Triacontanol
Topramezone Pyroxasulfone Triacontanol
Topramezone Mesotrione+Pyroxasulfone Fulvic acid
Topramezone Mesotrione+Pyroxasulfone Amino acid
Topramezone Mesotrione+Pyroxasulfone Seaweed extract
Topramezone Mesotrione+Pyroxasulfone Brassinolide
Topramezone Mesotrione+Pyroxasulfone Silicic acid
Topramezone Mesotrione+Pyroxasulfone Nitrobenzene
Topramezone Mesotrione+Pyroxasulfone Gibberellic acid
Topramezone Mesotrione+Pyroxasulfone Triacontanol
Topramezone Tembotrione+Pyroxasulfone Fulvic acid
Topramezone Tembotrione+Pyroxasulfone Amino acid
Topramezone Tembotrione+Pyroxasulfone Seaweed extract
Topramezone Tembotrione+Pyroxasulfone Brassinolide
Topramezone Tembotrione+Pyroxasulfone Silicic acid
Topramezone Tembotrione+Pyroxasulfone Nitrobenzene
Topramezone Tembotrione+Pyroxasulfone Gibberellic acid
Topramezone Tembotrione+Pyroxasulfone Triacontanol
Topramezone Metribuzin+Pyroxasulfone Fulvic acid
Topramezone Metribuzin+Pyroxasulfone Amino acid
Topramezone Metribuzin+Pyroxasulfone Seaweed extract
Topramezone Metribuzin+Pyroxasulfone Brassinolide
Topramezone Metribuzin+Pyroxasulfone Silicic acid
Topramezone Metribuzin+Pyroxasulfone Nitrobenzene
Topramezone Metribuzin+Pyroxasulfone Gibberellic acid
Topramezone Metribuzin+Pyroxasulfone Triacontanol
Topramezone Tolpyralate+Atrazine Fulvic acid
Topramezone Tolpyralate+Atrazine Amino acid
Topramezone Tolpyralate+Atrazine Seaweed extract
Topramezone Tolpyralate+Atrazine Brassinolide
Topramezone Tolpyralate+Atrazine Silicic acid
Topramezone Tolpyralate+Atrazine Nitrobenzene
Topramezone Tolpyralate+Atrazine Gibberellic acid
Topramezone Tolpyralate+Atrazine Triacontanol
Topramezone Metribuzin+Halosulfuron methyl Fulvic acid
Topramezone Metribuzin+Halosulfuron methyl Amino acid
Topramezone Metribuzin+Halosulfuron methyl Seaweed extract
Topramezone Metribuzin+Halosulfuron methyl Brassinolide
Topramezone Metribuzin+Halosulfuron methyl Silicic acid
Topramezone Metribuzin+Halosulfuron methyl Nitrobenzene
Topramezone Metribuzin+Halosulfuron methyl Gibberellic acid
Topramezone Metribuzin+Halosulfuron methyl Triacontanol
The herbicidal combination of the present invention maybe used to control the target weeds among the crops such as GMO (Genetically Modified Organism) and Non GMO varieties of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Oat (Avena sativa), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum), Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus) , Mustard (Brassica juncea), Rape seed (Brassica napus), Linseed (Linum usitatissimum), Sesame (Sesamum indicum), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa subsp rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Litchi (Litchi chinensis), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum) , Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum), Ajwain (Trachyspermum ammi), Psyllium (Plantago ovate), Black Pepper (Piper nigrum), Stevia (Stevia rebaudiana), Safed musli (Chlorophytum tuberosum), Drum stick (Moringa oleifera), Coconut (Coco nucifera), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold (Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera (Gerbera jamesonii), Carnation (Dianthus caryophyllus).
The present invention of synergistic herbicidal combinations can be also used to control unwanted vegetation in plantation crops, orchards, fallow lands, water bodies, field bunds etc.
A herbicidal synergistic composition of present invention controls all kind of monocots, dicots and sedges weeds. The present synergistic herbicidal combinations also controls annual and perennial weeds. The most common weeds controlled by present inventions are Abutilon indicum, Acalypha indica, Acanthospermum hispidum, Achyranthes aspera, Aerva tomentosa, Ageratum conyzoides, Alhagi camelorum, Amaranthus hybridus, Amaranthus spinosus, Amaranthus viridis, Ammannia baccifera, Anagallis arvensis, Argemone mexicana, Artemisia nilagiricia, Asphodelus tenuifolius, Avena fatua, Avena ludoviciana, Bidens pilosa, Boerhaavia diffusa, Boerhavia repanda, Brachiaria mutica, Brassica kaber, Bromus tectorum, Calotropis gigantea, Cannabis sativa, Carthamus axyacantha, Cassia tora, Celosia argentea, Centella asiatica, Chenopodium album, Chenopodium murale, Chloris barbata, Chrozophora rottlerii, Cichorium intybus, Cirsium arvense, Clitoria ternatea, Cnicus arvensis, Commelina benghalensis, Commelina communis, Convolvulus arvensis, Conyza canadensis, Corchorus acutangulus, Coronopus didymus, Crotalaria serice, Cucumis callosus, Cuscuta campestris, Cuscuta chinensis, Cynodon dactylon, Cyanotis axillaris, Cyperus esculenthus, Cyperus iria, Cyperus rotundus, Dactyloctenium aegyptium, Datura stramonium, Daucus carota, Digera arvensis, Digitaria sanguinalis, Dinebra retroflexa, Echinochola colonum, Echinochola crusgalli, Eclipta alba, Eichhornia crassipes, Elephantopus scaber, Eleusine indica, Eragrostis major, Euphorbia geniculata, Euphorbia hirta, Fimbristylis miliacea, Fumaria indica, Gynandropsis gynandra, Heliotropium indicum, Indigofera glandulosa, Ipomea aquatica, Lantana camara, Lathyrus aphaca, Launaea asplenifolia, Launaea nudicaulis, Leucas aspera, Ludwigia parviflora, Marsilea quadrifoliata, Medicago denticulate, Mimosa pudica, Melilotus alba, Melilotus indica, Ocimum canum, Oenothera biennis, Opuntia dillenil, Orobanche ramosa, Oryza longistaminata, Oryza sativa, Oxalis corniculata, Oxalis latifolia, Parthenium hysterophorus, Paspalum sanguinale, Phalaris minor, Phyllanthus niruri, Physalis minima, Polypogon monspeliensis, Portulaca oleracea, Prosopis juliflora, Rumex dentatus, Saccharum spontaneum, Stearia glauca, Seteria viridis, Sida spinosa, Silene antirrhina, Sisymbrium irio, Solanum nigrum, Solanum surattense, Sonchus oleraceous, Sorghum halepense, Spergula arvensis, Sphenocleazeylanica Gaertn, Striga asiatica, Tagetes minuta, Trianthema monogyna, Trianthema portulacastrum, Tribulus terrestris, Trigonelia polycerata, Vernonia cinerea, Vicia sativa and Xanthium strumarium.
Formulation of the present invention can be in any of the formulations selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Jambo balls or bags (bags in water soluble pouch), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion (SE), Soluble concentrate (SL), Water dispersible granule (WG or WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), A mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), Controlled release granules (CR).
Further formulation for the present synergistic agrochemical composition comprises ‘crop safener’ for use especially in monocotyledonous crops (wheat, paddy/rice, corn/maize, sugarcane, sorghum, pearlmillet).
In an embodiment of the present invention any one of the crop safener for the monocotyledonous crops is selected from the cyprosulfamide, dietholate, isoxadifen / isoxadifen ethyl, dicyclonon, benoxacor, mefenpyr ethyl, fenchlorazole ethyl, cloquintocet / cloquintocet mexyl, oxabetrinil, naphthalic anhydride, mephenate, mefenpyr, furilazole, fluxofenim, flurazole, fenclorim, fenchlorazole, dichlormid, cyometrinil.
One or more of the active ingredients is encapsulated for various purposes, such as to increase the residual biological activity, or to reduce the acute toxicity, or to obtain a physical or chemically stable water-based formulation. The purpose determines whether the “free” active ingredient and the “release rate” are relevant properties of a specific product.
Further herbicidal compositions comprising bioactive amounts of (A) a herbicide Topramezone; (B) a one or more herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof; and (C) a plant health additive(s) for reducing phytotoxicity in crops followed by application of a herbicide or mixture thereof are present in the said composition in specific fixed ratio.
In further aspect the present invention relates to the synergistic herbicidal composition comprising bioactive amounts of (A) is 0.1 to 50% w/w of the composition; (B) is 0.1 to 50% w/w of the composition; and (C) is 0.001 to 30% w/w of the composition.
Active Ingredients Compound A Compound
B Compound
C
Examples Topramezone One or more herbicide(s) Plant Health additives as safener
% of active ingredients (w/w, w/v) 0.1 to 50% 0.1 to 50% 0.001 to 30%

The composition of the present invention in addition to bioactive amounts of active ingredients further comprises inactive excipients including but not limited to wetting-spreading-penetrating agent, dispersant or dispersing agent, anti-freezing agent, anti-foam agent, suspension aid, disintegrating agent, thickener, preservative and carrier.
A wetting agent is a substance that when added to a liquid increases the spreading or penetration power of the liquid by reducing the interfacial tension between the liquid and the surface on which it is spreading. Wetting agents are used for two main functions in agrochemical formulations: during processing and manufacture to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates; and during mixing of a product with water in a spray tank or other vessel to reduce the wetting time of wettable powders and to improve the penetration of water into water-dispersible granules.
Examples of wetting-spreading-penetrating agent used herein for SC (Suspension concentrate) formulation include but not limited to ethylene oxide/propylene oxide block copolymer, polyarylphenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate, organosilicons surfactants (as a wetting-spreading-penetrating agent) includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof.
Examples of wetting-spreading-penetrating agent used herein for WG (Wettable Granule), WDG (Water Dispersible Granule) formulation includes but not limited to sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonate, sodium salt, mixture of isomers of dibutyl naphthalene sulphonic acid sodium salt, sodium di-isopropyl naphthalene sulphonate, sodium Lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulphosuccinates and non-ionic such as tridecyl alcohol ethoxylate, alkyl or alkaryl sulfonates such as alkylbenzene sulfonates, alpha olefin sulfonate and alkyl naphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphate esters, alkyl polysaccharide, di or mono alkyl sulfosuccinate derivatives, alpha olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulphosuccinates, butyl, dibutyl, isopropyl and di-isopropyl naphthalene sulfonate salts, C12 alkyl benzene sulfonate or C10-C16 alkyl benzene sulfonate, organosilicons surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, trisiloxane heptamethyl, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof.
A dispersant or a dispersing agent is a substance which adsorbs onto the surface of particles and helps to preserve the state of dispersion of the particles and prevents them from re-aggregating. Dispersants are added to agrochemical formulations to facilitate dispersion and suspension during manufacture, and to ensure the particles re-disperse into water in a spray tank. They are widely used in wettable powders, suspension concentrates and water-dispersible granules. Surfactants that are used as dispersants have the ability to adsorb strongly onto a particle surface and provide a charged or steric barrier to re-aggregation of particles. The most commonly used surfactants are anionic, non-ionic, or mixtures of the two types. For wettable powder formulations, the most common dispersants are sodium lingo sulphonates. In recent years, new types of very high molecular weight polymeric surfactants have been developed as dispersants. These have very long hydrophobic ‘backbones’ and a large number of ethylene oxide chains forming the ‘teeth’ of a ‘comb’ surfactant. These high molecular weight polymers can give very good long-term stability to suspension concentrates because the hydrophobic backbones have many anchoring points onto the particle surfaces.
Examples of dispersants or dispersing agent used herein for SC (Suspension concentrate) formulation include but not limited to alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium ploycarboxylate,EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide.
Examples of dispersants or dispersing agent used herein for WG (Wettable Granule), WDG (Water Dispersible Granule) formulation include but not limited to naphthalene sulfonic acid, sodium salt condensated with formaldehyde, polyalcoxylated alkylphenol, naphthalenesulfonic acid formaldehyde condensate, methylnaphtaline-formaldehyde-condensate sodium salt, napthalene condensates, lignosulfonates, polyacrylates and phosphate esters, calcium lignosulfonate,lignin sulfonate sodium salt;
Antifoaming agent for the present formulation is selected from various compounds and selectively used according to the formulation. Generally, there are two types of antifoam agents, namely silicones and non-silicones. Silicones are usually aqueous emulsions of dimethyl poly siloxane while the non-silicone anti-foam agents are water- insoluble oils, such as octanol and nonanol, or silica. In both cases, the function of the anti-foam agent is to displace the surfactant from the air-water interface.
Examples of Antifoaming agent used herein for SC (Suspension concentrate) formulation include but not limited to silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkylene oxide modified polydimethylsiloxane.
Examples of Antifoaming agent used herein for WG (Wettable Granule), WDG (Water Dispersible Granule) formulation includes but not limited to polydimethyl siolxane.
Anti-freezing agent for the present formulation is selected from various compounds and selectively used according to the formulation.
Examples of Anti-freezing agent used herein for SC (Suspension concentrate) formulation include but not limited to ethylene glycol, propane diols, glycerine or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerine, urea, magnesium sulfate heptahydrate, sodium chloride.
Disintegrating agent used herein for the WG (Wettable Granule), WDG (Water Dispersible Granule) formulation is selected from citric acid, succinic acid or the sodium bicarbonate.
Preservative used herein for the SC (Suspension concentrate) formulation and Oil dispersion (OD) formulation include but not limited to 1,2-benzisothiazolin-3(2H)-one, sodium salt, Sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, Formaldehyde, Sodium o-phenylphenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one.
Thickeners or gelling agents are used mainly in the formulation of suspension concentrates, emulsions and suspoemulsions to modify the rheology or flow properties of the liquid and to prevent separation and settling of the dispersed particles or droplets. Thickening, gelling, and anti-settling agents generally fall into two categories, namely water-insoluble particulates and water-soluble polymers.
Examples of thickeners used herein for SC (Suspension concentrate) formulation include but not limited to xanthan gum, PVK, carboxymethylcelluloses, polyvinyl alcohols,gelatin, sodium carboxymethylcellulose, hydroxyethylcellulose, sodium polyacrylate, modified starch;
Suspension aid or the suspending agent in the present description denotes a natural or synthetic, organic or inorganic material with which the active substance is combined in order to facilitate its application to the plant, to the seeds or to the soil. This carrier is hence generally inert, and it must be agriculturally acceptable, in particular to the plant being treated. The carrier may be solid (clays, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, and the like or mixtures thereof) or liquid (water, alcohols, ketones, petroleum fractions, aromatic or paraffinic hydrocarbons, chlorinated hydrocarbons, liquefied gases, and the like or mixtures thereof).
Examples of suspending agent used herein for SC (Suspension concentrate) formulation, include but not limited to Aluminum Magnesium Silicate, Bentonite clay, Silica, Attapulgite clay.
Certain vegetables/plant/seed oils as a carrier, increases the bioefficacy and residual control of products through increase in penetration of active ingredients into leaf surface, improves the retention of active ingredients on leaf surface especially on waxy leaf surface, improves the spreading properties and thereby improves the spray coverage.
Examples of Carrier used herein for WG (Wettable Granule), WDG (Water Dispersible Granule) formulation includes but not limited to china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulfate, sodium chloride, gypsum, calcium sulfate, pyrophyllite, silicates and silica gels; fertilizers such as, for example, ammonium sulfate, ammonium phosphate, ammonium nitrate and urea; natural products of vegetable origin such as, for example, grain meals and flours, bark meals, wood meals, nutshell meals and cellulosic powders; and synthetic polymeric materials such as, for example, ground or powdered plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers.
Examples of disintegrating agent used herein for WG (Wettable Granule), WDG (Water Dispersible Granule) formulation includes but not limited to citric acid, succinic acid or the sodium bicarbonate.
The process for preparing the present novel synergistic composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However all such variation and modification is still covered by the scope of present invention.
While the foregoing written description of the invention enables one of ordinary skill to make and use what is considered presently to be the best mode thereof, those of ordinary skill will understand and appreciate the existence of variations, combinations, and equivalents of the specific embodiment, method, and examples herein. The invention should therefore not be limited by the above described embodiment, method, and examples, but by all embodiments and methods within the scope and spirit of the invention. The invention shall now be described with reference to the following specific examples. It should be noted that the example(s) appended below illustrate rather than limit the invention, and that those skilled in the art will be able to design many alternative embodiments without departing from the scope of the present invention.
These and other aspects of the invention may become more apparent from the examples set forth herein below. These examples are provided merely as illustrations of the invention and are not intended to be construed as a limitation thereof.

EXAMPLE 1:
Topramezone 2.5%+Tolpyralate 5%+Fulvic acid 1.25% SC (Suspension concentrate)
Chemical composition % (w/w)
Topramezone a.i. 2.50
Tolpyralate a.i. 5.00
Fulvic acid a.i. 1.25
Trisiloxane ethoxylate 5.00
Naphthalenesulfonic acid, sodium salt condensated with formaldehyde 2.00
Tristyrylphenole with 16 moles EO 3.00
Bentonite clay 1.50
Polydimethyl siloxane 0.50
2-bromo-2-nitropropane-1,3-diol 0.20
Polypropylene glycol 5.00
Xanthan gum 0.15
Water 73.90
Total 100.00

Stability Study:
Study in laboratory (at 54±2 C & At 0±2 C temp. for 14 days) and at room temperature (for 12 months) shows that Topramezone 2.5%+Tolpyralate 5%+Fulvic acid 1.25% SC (Suspension Concentrate) formulation complies all the in-house parameters like active ingredients content, suspensibility, pH range, pourability, specific gravity, viscosity, particle size and anti-foaming.
Procedure: Manufacturing process for SC (Suspension Concentrate) formulation.
Step 1 2% Gel Preparation: Charge the required quantity of water to a vessel, equipped with a high shear stirrer and start the agitation. Add the required amount of preservative. Mix until homogenous. Add the required amount of thickener and mix vigorously until it is fully wetted.
Step 2 Charge the required quantity of water to a vessel, equipped with bulk agitator and a high shear homogenizer and start agitation. Add the required amount of ant freezing agent and mix until uniform. Add the antifoaming agent and ensure that it is well dispersed. Add the wetting and dispersing agent and mix until uniform. Ensure that the dispersing agent is fully dispersed.
Step 3 Now add the active ingredient and continue agitating the vessel contents until all components get dissolved. Mill this pre-mix through a Colloid mill and subsequently through a Dyno mill to meet the specified particle size.
Step 4 Now add remaining antifoaming agent to this SC mill base to a vessel, equipped with bulk agitator. Mix until uniform. Add the required amount of 2% aqueous pre-gel and suspending agent and continue agitation until the formulation is homogeneous and has the target viscosity is reached.
Step 5 Final product is sent for QC approval.
Step 6 After approval, material is packed in required pack sizes.

EXAMPLE 2:
Topramezone 2.5%+Mesotrione 8%+Ortho silicic acid 1% SC (Suspension concentrate)
Chemical composition % (w/w)
Topramezone a.i. 2.50
Mesotrione a.i. 8.00
Ortho silicic acid a.i. 1.00
Trisiloxane ethoxylate 5.00
Naphthalenesulfonic acid, sodium salt condensated with formaldehyde 2.00
Tristyrylphenole with 16 moles EO 3.00
Bentonite clay 1.50
Polydimethyl siloxane 0.50
2-bromo-2-nitropropane-1,3-diol 0.20
Polypropylene glycol 5.00
Xanthan gum 0.15
Water 71.15
Total 100.00

Stability Study: Study in laboratory (at 54±2 C & At 0±2 C temp. for 14 days) and at room temperature (for 12 months) shows that Topramezone 2.5%+Mesotrione 8%+Ortho silicic acid 1% SC (Suspension Concentrate) formulation complies all the in-house parameters like active ingredients content, suspensibility, pH range, pourability, specific gravity, viscosity, particle size and anti-foaming
Procedure: Manufacturing process for SC (Suspension Concentrate) formulation as per Example 1.

EXAMPLE 3:
Topramezone 2.5%+Metribuzin 70%+Fulvic acid 1.25% WG (Water dispersible granule/Wettable Granule)
Chemical composition % (w/w)
Topramezone a.i. 2.50
Metribuzin a.i. 70.00
Fulvic acid a.i. 1.25
Trisiloxane heptamethyl 5.00
Alkylnaphthalene sulfonate sodium salt 6.00
Sodium Polycarboxylate 3.00
Sodium sulphate anhydrous 8.00
Polydimethyl siloxane 0.50
Corn starch 3.75
Total 100.00

Stability Study: Study in laboratory (at 54±2 0C & At 0±2 0C for 14 days) and at room temperature (for 12 months) shows that Topramezone 2.5%+Metribuzin 70&+Fulvic acid 1.25% WG formulation complies all the in-house parameters like active ingredients content, suspensibility, wettability, wet sieve percent by mass, pH range and moisture content.
Procedure: Manufacturing process for Water Dispersible Granules (WG) formulation:

Procedure: Manufacturing process of Water Dispersible Granules (WG):

Step 1 Before starting the process, check the cleanliness of all equipment’s in plant and get approval by QC dept.
Step 2 Check the electrical connection and standardize the weighing balance.
Step 3 Take exact weight of active ingredients (technical) in blender and then add required quantity of binder & surfactants and mix it till its complete homogenization.
Step 4 Mill this homogenized Mixture till required wet sieve and post blend again for homogeneity.
Step 5 Pass the above homogenous material through Extruder for granulation.
Step 6 Now transfer the granules through Fluid Bed Dryer to remove excess moisture.
Step 7 Transfer these granules to vibro shifter.
Step 8 Collect the final material from the vibro shifter into drum.
Step 9 Finally send the sample to QC for approval.
Step 10 After approval by QC, transfer the material into different size of drums.

EXAMPLE 4:
Most Preferred formulations:
Compound A Compound B Compound C Active ingredients (%) Formulation Strength (%) Formulation Type
A B C
Topramezone Halosulfuron methyl Fulvic acid 10 30 5 45.00 WG
Topramezone Pyrazosulfuron ethyl Fulvic acid 5 5 2.5 12.50 SC
Topramezone Nicosulfuron Fulvic acid 10 20 5 35.00 WG
Topramezone Isoxaflutole Fulvic acid 10 40 5 55.00 WG
Topramezone Tolpyralate Fulvic acid 2.5 5 1.25 8.75 SC
Topramezone Mesotrione Fulvic acid 2.5 8 1.25 11.75 SC
Topramezone Tembotrione Fulvic acid 2.5 8 1.25 11.75 SC
Topramezone Sulcotrione Fulvic acid 2.5 8 1.25 11.75 EC
Topramezone Atrazine Fulvic acid 2.5 70 1.25 73.75 WG
Topramezone Metribuzin Fulvic acid 2.5 70 1.25 73.75 WG
Topramezone Pyroxasulfone Fulvic acid 10 30 5 45.00 WG
Topramezone Halosulfuron methyl Ortho silicic acid 10 30 4 44.00 WG
Topramezone Pyrazosulfuron ethyl Ortho silicic acid 10 10 4 24.00 WG
Topramezone Nicosulfuron Ortho silicic acid 10 20 4 34.00 WG
Topramezone Isoxaflutole Ortho silicic acid 10 40 4 54.00 WG
Topramezone Tolpyralate Ortho silicic acid 2.5 5 1 8.50 SC
Topramezone Mesotrione Ortho silicic acid 2.5 8 1 11.50 SC
Topramezone Tembotrione Ortho silicic acid 2.5 8 1 11.50 SC
Topramezone Sulcotrione Ortho silicic acid 2.5 8 1 11.50 EC
Topramezone Atrazine Ortho silicic acid 0.7 20 0.28 20.98 SC
Topramezone Metribuzin Ortho silicic acid 0.7 20 0.28 20.98 SC
Topramezone Pyroxasulfone Ortho silicic acid 10 30 4 44.00 WG
Topramezone Halosulfuron methyl Triacontanol 5 15 0.2 20.20 SC
Topramezone Pyrazosulfuron ethyl Triacontanol 5 5 0.2 10.20 SC
Topramezone Nicosulfuron Triacontanol 5 10 0.2 15.20 SC
Topramezone Isoxaflutole Triacontanol 5 20 0.2 25.20 SC
Topramezone Tolpyralate Triacontanol 2.5 5 0.1 7.60 SC
Topramezone Mesotrione Triacontanol 2.5 8 0.1 10.60 SC
Topramezone Tembotrione Triacontanol 2.5 8 0.1 10.60 SC
Topramezone Sulcotrione Triacontanol 2.5 8 0.1 10.60 EC
Topramezone Atrazine Triacontanol 0.7 20 0.029 20.73 SC
Topramezone Metribuzin Triacontanol 0.7 20 0.029 20.73 SC
Topramezone Pyroxasulfone Triacontanol 10 30 0.4 40.40 WG
Topramezone Halosulfuron methyl Gibberellic acid 5 15 0.2 20.20 SC
Topramezone Pyrazosulfuron ethyl Gibberellic acid 5 5 0.2 10.20 SC
Topramezone Nicosulfuron Gibberellic acid 5 10 0.2 15.20 SC
Topramezone Isoxaflutole Gibberellic acid 5 20 0.2 25.20 SC
Topramezone Tolpyralate Gibberellic acid 2.5 5 0.1 7.60 SC
Topramezone Mesotrione Gibberellic acid 2.5 8 0.1 10.60 SC
Topramezone Tembotrione Gibberellic acid 2.5 8 0.1 10.60 SC
Topramezone Sulcotrione Gibberellic acid 2.5 8 0.1 10.60 EC
Topramezone Atrazine Gibberellic acid 0.7 20 0.029 20.73 SC
Topramezone Metribuzin Gibberellic acid 0.7 20 0.029 20.73 SC
Topramezone Pyroxasulfone Gibberellic acid 10 30 0.4 40.40 WG

BIOLOGICAL EXAMPLES:
The field experiments were carried out to judge the impact of plant health additives on crop safety and yield attributing parameters when applied with herbicidal compositions containing Topramezone as inbuilt formulation and tank mixes.
Phytotoxicity: The observations on crop safety i.e. phytotoxicity or adverse effect of treatments were recorded on 7th, 14th and 21st DAA (days after application). All the visual phytotoxicity symptoms like plant stunting, yellowing, leaf scorching, bleaching, necrosis, stunting, crinkling, epinasty, hyponasty recorded visually by rating (0 to 100%) the entire plot in comparison with untreated control (UTC) plot.

Weed control: Species wise weed count recorded at 14 DAA and 30 DAA (Days after Application) by using 0.25 m2 quadrant treatment wise in minimum 3 places randomly selected in the plot. The species wise weed count further grouped in to Grasses and Broad Leaf weeds (BLW) and sedges. The average of each variable was used together with the sum of all the variables per plot to calculate the percentage of control.

The % weed control data used in Colby’s formula to calculate the synergism.
A synergistic effect exists wherever the action of a combination of active ingredient is greater than the sum of the action of each of the components alone. Therefore, a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticidal activity than the sum of the pesticidal activities of the individual components.

Example 5: Crop safety and weed control in maize, Zea mays
The field experiment were conducted in maize/corn crop and the experimental details are as below:
Crops: Maize
No. of Treatments: As per treatment details
Plot size: 24 sq. mt.
Application Time: At 3 to 4 leaf stage of weed. 20 DAS (Days after sowing)
Spray Volume: 375 liter water per hectare
Application Equipment: Manually operated knapsack sprayer fitted with flat fat nozzle
Agronomic practices: All the required agronomic practices followed except herbicidal application.

Table 1: Treatment details for crop safety study
Treatment number Treatment details Rate (gai/h)
T1 Topramezone 10%+Halosulfuron methyl 30%+Fulvic acid 5% WG+Adjuvant @2 ml/l 25+75+12.5
T2 Topramezone 2.5%+Tolpyralate 5%+Fulvic acid 1.25% SC 25+50+12.5
T3 Topramezone 2.5%+Mesotrione 8%+Fulvic acid 1.25% SC 25+80+12.5
T4 Topramezone 2.5%+Tembotrione 8%+Fulvic acid 1.25% SC 25+80+12.5
T5 Topramezone 2.5%+Atrazine 70%+Fulvic acid 1.25% WG+Adjuvant @2 ml/l 25+700+12.5
T6 Topramezone 2.5%+Metribuzin 70%+Fulvic acid 1.25% WG+Adjuvant @2 ml/l 25+700+12.5
T7 Topramezone 33.6% SC+Halosulfuron methyl 75% WG+Adjuvant @ 2 ml/l 25+75
T8 Topramezone 33.6% SC+Tolpyralate 40% SC+Adjuvant @2 ml/l 25+50
T9 Topramezone 33.6% SC+Mesotrione 40% SC+Adjuvant @2ml/l 25+80
T10 Topramezone 33.6% SC+Tembotrione 34.4% SC+Adjuvant@2 ml/l 25+80
T11 Topramezone 33.6% SC+Atrazine 50% WP+Adjuvant @2 ml/l 25+700
T12 Topramezone 33.6% SC+Metribuzin 70% WP+Adjuvant @2ml/l 25+700
T13 Topramezone 33.6% SC+Adjuvant @2 ml/l 25
T14 Halosulfuron methyl 75% WG+Adjuvant @ 2 ml/l 75
T15 Tolpyralate 40% SC+Adjuvant @ 2 ml/l 50
T16 Mesotrione 40% SC+Adjuvant @ 2ml/l 80
T17 Tembotrione 34.4% SC+Adjuvant 2 ml/l 80
T18 Atrazine 50% WP 700
T19 Metribuzin 70% WP 700
T20 Fulvic acid 80% WP 12.5
T21 Untreated control (UTC) -

Table 2: Crop safety observations
Treatment number Weed control (%) on 14 DAA
Observed Value Calculated Value Colby's ratio Synergism (Y/N)
T1 96.4 91.92 1.05 Y
T2 98.2 94.61 1.04 Y
T3 97.6 93.63 1.04 Y
T4 98.2 94.31 1.04 Y
T5 97.2 90.68 1.07 Y
T6 97.4 92.77 1.05 Y
T7 94.6 91.84 1.03 Y
T8 96.2 94.56 1.02 Y
T9 95.4 93.56 1.02 Y
T10 96.2 94.25 1.02 Y
T11 94.6 90.58 1.04 Y
T12 95.2 92.70 1.03 Y
T13 78.4
T14 62.2
T15 74.8
T16 70.2
T17 73.4
T18 56.4
T19 66.2
T20 1.0
T21 0.0
Weed flora present in trials plots were Grassy weeds-Echinochloa spp., Dactyloctenium spp., Eragrostis spp., Broad leaf weeds-Amaranthus viridis, Digera arvensis and Euphorbia hirta.
The treatments of Topramezone+herbicide+fulvic acid (T1 to T6) provides synergistic weed control.
Table 3: Crop safety with treatments of Topramezone+Herbicide+Fulvic acid
Treatment number Yellowing (%) Plant height (cm) Increase(%) in plant height over
7 DAA 14 DAA 21 DAA 7 DAA 14 DAA 21 DAA
T1 5.0 0.0 0.0 21.17 29.08 40.28 6.39 (over T7)
T2 5.0 0.0 0.0 20.96 28.87 40.82 10.50 (over T8)
T3 5.0 0.0 0.0 21.26 29.68 40.75 6.84 (over T9)
T4 5.0 0.0 0.0 21.08 29.31 40.75 8.26 (over T10)
T5 5.0 0.0 0.0 20.89 28.96 40.16 6.89 (over T11)
T6 10.0 5.0 0.0 20.94 29.19 40.52 10.05 (over T12)
T7 20.0 10.0 5.0 19.26 26.89 37.86
T8 25.0 15.0 5.0 18.92 26.54 36.94
T9 20.0 10.0 5.0 19.46 27.10 38.14
T10 20.0 10.0 5.0 18.88 26.24 37.64
T11 10.0 5.0 0.0 19.10 26.57 37.57
T12 30.0 20.0 10.0 18.78 26.32 36.82
T13 10.0 5.0 0.0 19.58 27.10 38.10
T14 15.0 10.0 5.0 19.20 26.78 37.86
T15 15.0 10.0 5.0 19.86 27.34 38.24
T16 10.0 5.0 0.0 19.36 26.89 37.86
T17 10.0 5.0 0.0 19.16 26.92 37.43
T18 5.0 0.0 0.0 20.21 28.14 38.25
T19 20.0 15.0 10.0 18.62 26.62 36.87
T20 0.0 0.0 0.0 21.35 29.24 40.57
T21 0.0 0.0 0.0 21.16 29.18 40.68

The treatments of Topramezone+herbicide+fulvic acid (T1 to T6) shows excellent crop safety with minimal yellowing symptoms and also increase plant height. The other visual observations shows higher plant biomass in the treatments of Topramezone+herbicide+fulvic acid (T1 to T6).

Example 6: Crop safety and weed control in Sugarcane, Saccharum officinarum
Crops: Sugarcane
No. of Treatments: As per treatment details
Plot size: 40 sq. mt.
Application Time: At 3 to 4 leaf stage of weed. 32 DAP (Days after planting)
Spray Volume: 400 liter water per hectare
Application Equipment: Manually operated knapsack sprayer fitted with flat fat nozzle
Agronomic practices: All the required agronomic practices followed except herbicidal application.
Table 4: Treatment details
Treatment number Treatment details Rate (gai/h)
T1 Topramezone 10%+Halosulfuron methyl 30%+Ortho silicic acid 4% WG+Adjuvant @2 ml/l 25+75+10
T2 Topramezone 10%+Pyrazosulfuron ethyl 10%+Ortho silicic acid 4% WG+Adjuvant @2ml/l 25+25+10
T3 Topramezone 10%+Nicosulfuron 20%+Ortho silicic acid 4% WG+Adjuvant @2ml/l 25+50+10
T4 Topramezone 10%+Isoxaflutole 40%+Ortho silicic acid 4% WG+Adjuvant @2 ml/l 25+100+10
T5 Topramezone 2.5%+Mesotrione 8%+Ortho silicic acid 1% SC 25+80+10
T6 Topramezone 2.5%+Tembotrione 8%+Ortho silicic acid 1% SC 25+80+10
T7 Topramezone 33.6% SC+Halosulfuron methyl 75% WG+Adjuvant @ 2 ml/l 25+75
T8 Topramezone 33.6% SC+Pyrazosulfuron ethyl 10% WP+Adjuvant @2 ml/l 25+25
T9 Topramezone 33.6% SC+Nicosulfuron 75% WG+Adjuvant @2ml/l 25+50
T10 Topramezone 33.6% SC+Isoxaflutole 75% WG+Adjuvant@2 ml/l 25+100
T11 Topramezone 33.6% SC+Mesotrione 40% SC+Adjuvant @2ml/l 25+80
T12 Topramezone 33.6% SC+Tembotrione 34.4% SC+Adjuvant@2 ml/l 25+80
T13 Topramezone 33.6% SC+Adjuvant @2 ml/l 25
T14 Halosulfuron methyl 75% WG+Adjuvant @ 2 ml/l 75
T15 Pyrazosulfuron ethyl 10% WP+Adjuvant @ 2 ml/l 50
T16 Nicosulfuron 75% WG+Adjuvant @2ml/l 50
T17 Isoxaflutole 75% WG+Adjuvant @2 ml/l 100
T18 Mesotrione 40% SC+Adjuvant @ 2ml/l 80
T19 Tembotrione 34.4% SC+Adjuvant 2 ml/l 80
T20 Ortho silicic acid 2% WP 10
T21 Untreated control (UTC) -

Table 5: Weed control in sugarcane
Treatment number Weed control (%) on 30 DAA
Observed Value Calculated Value Colby's ratio Synergism (Y/N)
T1 95.6 84.74 1.13 Y
T2 93.2 83.20 1.12 Y
T3 98.2 87.52 1.12 Y
T4 98.8 89.82 1.10 Y
T5 97.6 88.92 1.10 Y
T6 96.2 87.87 1.09 Y
T7 92.4 84.58 1.09 Y
T8 90.4 83.03 1.09 Y
T9 95.4 87.40 1.09 Y
T10 94.8 89.72 1.06 Y
T11 93.6 88.81 1.05 Y
T12 93.4 87.75 1.06 Y
T13 64.8
T14 56.2
T15 51.8
T16 64.2
T17 70.8
T18 68.2
T19 65.2
T20 1.0
T21 0.0

Major weed flora present in trials plots were Grassy weeds-Brachiaria mutica, Echinochloa colonum, Eleusine indica, Broad leaf weeds-Trianthema mongyna, Amaranthus spinosus, Physalis minima, Sedges-Cyperus rotundus.
The treatments of Topramezone + herbicide + Ortho silicic acid (T1 to T6) provides synergistic weed control.
Table 6: Crop safety
Treatment number Yellowing (%) Stunting (%) Number of tillers/mrl Increase(%) in tillers over
7 DAA 14 DAA 21 DAA 7 DAA 14 DAA 21 DAA
T1 5.0 0.0 0.0 5.0 0.0 0.0 82.90 8.79 (over T7)
T2 5.0 0.0 0.0 5.0 0.0 0.0 83.70 8.56 (over T8)
T3 5.0 0.0 0.0 5.0 0.0 0.0 81.70 8.50 (over T9)
T4 5.0 0.0 0.0 5.0 0.0 0.0 84.20 9.78 (over T10)
T5 5.0 0.0 0.0 5.0 0.0 0.0 82.70 9.83 (over T11)
T6 5.0 0.0 0.0 10.0 10.0 5.0 81.90 9.64 (over T12)
T7 10.0 5.0 0.0 10.0 10.0 5.0 76.20
T8 10.0 5.0 0.0 10.0 10.0 5.0 77.10
T9 10.0 5.0 0.0 10.0 10.0 5.0 75.30
T10 10.0 5.0 0.0 10.0 10.0 5.0 76.70
T11 10.0 5.0 0.0 10.0 10.0 5.0 75.30
T12 10.0 5.0 0.0 10.0 10.0 5.0 74.70
T13 5.0 0.0 0.0 5.0 0.0 0.0 72.70
T14 5.0 0.0 0.0 5.0 0.0 0.0 71.80
T15 5.0 0.0 0.0 5.0 0.0 0.0 72.70
T16 5.0 0.0 0.0 5.0 0.0 0.0 70.80
T17 5.0 0.0 0.0 5.0 0.0 0.0 71.30
T18 5.0 0.0 0.0 5.0 0.0 0.0 70.50
T19 5.0 0.0 0.0 5.0 0.0 0.0 71.90
T20 0.0 0.0 0.0 0.0 0.0 0.0 62.80
T21 0.0 0.0 0.0 0.0 0.0 0.0 59.20

The treatments of Topramezone + herbicide + ortho silicic acid (T1 to T6) shows excellent crop safety to sugarcane crop with minimal leaves yellowing and plant stunting symptoms with increase in number of tillers per 1 meter row length (mrl). The other visual observations shows higher plant biomass in the treatments of Topramezone + herbicide + ortho silicic acid (T1 to T6).

Summary of the biological experiments:
• Addition of plant health additives improves crop safety. If phytotoxicity symptoms appears, they were very mild and crop recovers very fast without loosing potential parameters for plant growth and yield.
• Provides better weed control i.e. increases weed control efficiency of herbicides.
• Increases yield.

CLAIMS:CLAIMS
We claim;
[CLAIM 1]. A synergistic agrochemical composition for reducing phytotoxicity comprises:
a. a herbicide Topramezone present in an amount of 0.1 to 50 % by weight or mixture thereof;
b. at least one herbicide(s) selected from the group of various class of compounds for control of broad-leaved weeds and grassy weeds and sedges in economical crops or mixture thereof present in an amount of 0.1 to 50% by weight or mixture thereof;
c. a plant health additive(s) for reducing phytotoxicity in crops followed by application of a herbicide or mixture thereof present in an amount of 0.001 to 30% by weight or mixture thereof.
d. inactive formulation excipients.

[CLAIM 2]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 1, wherein a herbicide of
Acetolactate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor from Sulfonylurea group is selected from chlorimuron ethyl, flazasulfuron, halosulfuron methyl, metsulfuron mehtyl, nicosufulfuron, primisulfuron methyl, pyrazosulfuron ehtyl, rimsulfuron, thifensulfuron-methyl, tribenuron methyl;
Acetoacetate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor from Pyrimidinyl(thio)benzoate group is selected from pyrithiobac sodium; from Triazolopyrimidine group is selected from diclosulam, florasulam, flumetsulam;
Acetoacetate Synthase (ALS) or Acetohydroxy Acid Synthase (AHAS) inhibitor of Sulfonylaminocarbonyl group is selected from thiencarbazone-methyl; from Imidazolinone group is selected from imazamox, imazapic, imazapyr, imazaquin, imazethapyr; from Sulfonanilides group is triafamone;
Synthetic Auxin of Phenoxy carboxylic acid group is selected from 2,4-D, MCPA, MCPB; of Pyridine carboxylic acid group is selected from aminopyralid, clopyralid, florpyrauxifen benzyl, fluroxypyr, picloram, triclopyr; of Benzoic acid group is selected from dicamba; of Quinoline carboxylic acid group is quinclorac; and halauxifen methyl;
Inhibitor of photosynthesis at photosystem II site A of Triazine group is selected from ametryn, atrazine, simazine; of Triazinone group is selected from hexazione, metamitron, metribuzin;
Inhibitor of photosynthesis at photosystem II site B of Benzothiadiazinone group is selected from bentazone; of Nitrile group is selected from bromoxynil, ioxynil; of Phenyl-pyridazine group is pyridate;
Inhibitor of 1-deoxy-D-xyulose 5-phosphate synthatase (DOXP synthase) of Isoxazolidinone group is clomazone;
from Inhibitor of protoporphyrinogen oxidase (Protox, PPO) of Dipheylether group is selected from aclifluorfen, bifenox, fluoroglycofen, fomesafen, lactofen, oxyfluorfen; of Triazolinone group is selected from azafenidin, carfentrazone-ethyl, flufenpyr-ethyl, sulfentrazone; of Pyrimidinedione group is selected from butafenacil, saflufenacil; of N-phenylphthalimide group is selected from flumiclorac, flumioxazin; of N-Phenyl-imide group is trifludimoxazin; of Thiadiazole group is fluthiacet-methyl; of Oxadiazole group is selected from oxadiargyl, oxadiazon; of Phenylpyrazole group is pyraflufen-ethyl, of other group is pyraclonil; of Uracil group is tiafenacil; of Pyrazole group is cyclopyranil;
Mitosis Inhibitor of Chloroacetamide group is selected from acetochlor, alachlor, butachlor, dimethenamid, metazachlor, pretilachlor, propachlor, S-metolachlor; of Tetrazolinone group is fentrazamide; of Oxyacetamide group is selected from flufenacet, mefenacet; of Acetamide group is napropamide; of Carbamate group is carbetamide;
Inhibitor of 7,8-dihydro-preroate synthetase (DHP) of Carbamate group is asulam;
Inhibitor of indoleacetic acid transport of Phthalamate semicarbazone group is selected from diflufenzopyr, naptalam;
Inhibitor of cell wall synthesis site C of Alkylazines group is selected from indaziflam, triaziflam;
Inhibitor of Hydroxyphenyl Pyruvate Dioxygenase (4-HPPD) of Pyrazole group is selected from benzofenap, pyrasulfotole, pyrazolynate, pyrazoxyfen, tolpyralate; of Benzoylbicyclooctanedione group is benzobicyclon; Triketone group is selected from mesotrione, tembotrione, sulcotrione, tefuryltrione, fenquinotrione, lancotrione sodium; of Isoxazoles group is selected from isoxaflutole; bicyclo ring compound group is bicyclopyrone;
Inhibitors of dihydroorotate dehydrogenase (DHODH) is tetflupyrolimet;
HTS (homogentisate solanesyltransferase)-a downstream enzyme of HPPD is cyclopyrimorate;
VLCAFE inhibitors of Isoxazoline group is pyroxasulfone, of Triazolinone group is ipfencarbazone, of Trifluoromethansulfonanilides group is dimesulfazet, and other compounds such as fenoxasulfone;
Inhibitors of Solanesyl Diphosphate Synthase (SDS) is aclonifen;
unknown mode of action is selected from diphenamid, naproanilide, napropamide, cacodylic acid, epyrifenacil, bixzolone.

[CLAIM 3]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 1, wherein a plant health additives is selected from humic acid (salts), fulvic acid (salts), amino acids (alanine, arginine, aspartic acid, cysteine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine or mixture thereof), protein hydrolysates, peptides, organic acid, acetylthioproline, thiazolidine carboxylic acid, jasmonic acid, methyl jasmonate, chitosan, chitin, seaweed extract (Ascophyllum nodosum), polyamines, silicic acid (salts)-orthosilicic acid (H4Si04), silica nanoparticles (10-100 nm), calcium silicate, potassium silicate, sodium silicate), silicyclic acid, lactic acid, phenyllactic acid, fumaric acid, acibenzolar-s-methyl, gibberellic acid, GA3, brassinolide, forchlorfenuron, triacontanol, silicyclic acid, Nitrophenolate (sodium para-nitrophenolate, ortho-nitrophenolate, sodium-5-nitroguaiacolate), nitrobenzene or mixture thereof; from group of micronutrients is selected from Zinc (zinc sulphate heptahydrate ZnSO47H2O, zinc sulphate mono hydrate ZnSO4.H2O, chelated zinc as Zn-EDTA, zinc oxide, Zinc Lactate Gluconate, Zinc Polyflavonoid), Boron (borax-sodium tetraborate, boric acid (H3BO3), di-sodium octa borate tetra hydrate (Na2B8O13.4H2O), di-sodium tetra borate penta hydrate, anhydrous borax, ), Manganese (manganese sulphate), Copper (copper sulphate), Iron (ferrous sulphate, chelated iron as Fe-EDTA), Molybdanum (ammonium molybdate), Magnesium (Magnesium sulphate) or Sulphur (elemental sulphur, boronated sulphur) and mixture thereof.

[CLAIM 4]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 1, wherein the formulation for the said composition is selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Jambo balls or bags (bags in water soluble pouch), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion (SE), Soluble concentrate (SL), Water dispersible granule (WG or WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), A mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), Controlled release granules (CR).

[CLAIM 5]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 1-claim 4, wherein the preferred composition for the Suspension Concentrate (SC) formulation comprises:
i. Topramezone 5 % + Pyrazosulfuron ethyl 5 % + Fulvic acid 2.5 %
ii. Topramezone 2.5 % + Tolpyralate 5 % + Fulvic acid 1.25 %
iii. Topramezone 2.5 % + Mesotrione 8 % + Fulvic acid 1.25 %
iv. Topramezone 2.5 % + Tembotrione 8 % + Fulvic acid 1.25 %
v. Topramezone 2.5 % + Tolpyralate 5 % + Ortho silicic acid 1 %
vi. Topramezone 2.5 % + Mesotrione 8 % + Ortho silicic acid 1 %
vii. Topramezone 2.5 % + Tembotrione 8 % + Ortho silicic acid 1 %
viii. Topramezone 0.7 % + Atrazine 20 % + Ortho silicic acid 0.28 %
ix. Topramezone 0.7 % + Metribuzin 20 % + Ortho silicic acid 0.28 %
x. Topramezone 5% + Halosulfuron methyl 15% +Triacontanol 0.2 %
xi. Topramezone 5 % + Pyrazosulfuron ethyl 5 %+Triacontanol 0.2 %
xii. Topramezone 5 % + Nicosulfuron 10 % + Triacontanol 0.2 %
xiii. Topramezone 5 % + Isoxaflutole 20 % + Triacontanol 0.2 %
xiv. Topramezone 2.5 % + Tolpyralate 5 % + Triacontanol 0.1 %
xv. Topramezone 2.5 % + Mesotrione 8 % + Triacontanol 0.1 %
xvi. Topramezone 2.5 % + Tembotrione 8 % + Triacontanol 0.1 %
xvii. Topramezone 0.7 % + Atrazine 20 % + Triacontanol 0.029 %
xviii. Topramezone 0.7 % + Metribuzin 20 % + Triacontanol 0.029 %
xix. Topramezone 5% + Halosulfuron methyl 15% + Gibberellic acid 0.2 %
xx. Topramezone5%+Pyrazosulfuron ethyl 5%+Gibberellic acid 0.2 %
xxi. Topramezone 5 % + Nicosulfuron 10 % + Gibberellic acid 0.2 %
xxii. Topramezone 5 % + Isoxaflutole 20 % + Gibberellic acid 0.2 %
xxiii. Topramezone 2.5 % + Tolpyralate 5 % + Gibberellic acid 0.1 %
xxiv. Topramezone 2.5 % + Mesotrione 8 % + Gibberellic acid 0.1 %
xxv. Topramezone 2.5 % + Tembotrione 8 % + Gibberellic acid 0.1 %
xxvi. Topramezone 0.7 % + Atrazine 20 % + Gibberellic acid 0.029 %
xxvii. Topramezone 0.7 % + Metribuzin 20 % + Gibberellic acid 0.029%

[CLAIM 6]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 1 and claim 5, wherein the Suspension Concentrate (SC) formulation comprises:
i. a herbicide Topramezone present in an amount of 0.1 to 50 % by weight or mixture thereof;
ii. at least one herbicide(s) selected from Pyrazosulfuron ethyl, Tolpyralate, Mesotrione, Tembotrione, Atrazine, Metribuzin, Pyrazosulfuron ethyl, Nicosulfuron, Isoxaflutole or mixture thereof present in an amount of 0.1 to 50% by weight or mixture thereof;
iii. a plant health additive(s) is selected from Fulvic acid, Ortho silicic acid, Triacontanol, Gibberellic acid or mixture thereof present in an amount of 0.001 to 30% by weight or mixture thereof.
iv. Wetting-spreading-penetrating agent present in an amount of 4 to 10% by weight;
v. Dispersing agent I present in an amount of 2 to 10 % by weight;
vi. Dispersing agent II present in an amount of 2 to 5 % by weight;
vii. Disintegrating agent present in an amount of 4 to 10 % by weight;
viii. Antifoaming agent present in an amount of 0.1 to 1 % by weight;
ix. Anti-freezing agent present in an amount of 0.1 to 1 % by weight;
x. Suspending agent present in an amount of 0.1 to 1 % by weight;
xi. Thickener present in an amount of 5 to 30 % by weight;
xii. Diluent water.

[CLAIM 7]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 6, wherein Wetting-spreading-penetrating agent is selected from ethylene oxide/propylene oxide block copolymer, polyarylphenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate, organosilicons surfactants (as a wetting-spreading-penetrating agent) includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof.

[CLAIM 8]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 6, wherein dispersing agent is selected from alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium ploycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyryl phenol-polyglycol ether-phosphate, tristyryl phenole with 16 moles EO, tristyryl phenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide.

[CLAIM 9]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 6, wherein suspending agent is selected from aluminum magnesium silicate, bentonite clay, silica, attapulgite clay.

[CLAIM 10]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 6, wherein anti-freezing agent is selected from ethylene glycol, propane diols, glycerine or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerine, urea, magnesium sulfate heptahydrate, sodium chloride.

[CLAIM 11]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 6, wherein preservative is selected from 1,2-benzisothiazolin-3(2H)-one, sodium salt, Sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, Formaldehyde, Sodium o-phenylphenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one.

[CLAIM 12]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 6, wherein thickeners is selected xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch.

[CLAIM 13]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 1-claim 4 wherein, the preferred composition for the Water Dispersible Granule/Wettable Granule (WG) formulation comprises:
i. Topramezone 10%+ Halosulfuron methyl 30%+ Fulvic acid 5 %
ii. Topramezone 10 % + Nicosulfuron 20 % + Fulvic acid 5 %
iii. Topramezone 10 % + Isoxaflutole 40 % + Fulvic acid 5 %
iv. Topramezone 2.5 % + Atrazine 70 % + Fulvic acid 1.25 %
v. Topramezone 2.5 % + Metribuzin 70 % + Fulvic acid 1.25 %
vi. Topramezone 10 % + Pyroxasulfone 30 % + Fulvic acid 5 %
vii. Topramezonen 10 % + Halosulfuron methyl 30 % + Ortho silicic acid 4 %
viii. Topramezone 10% + Pyrazosulfuron ethyl 10 % +Ortho silicic acid 4%
ix. Topramezone 10%+ Nicosulfuron 20 % + Ortho silicic acid 4%
x. Topramezone 10% + Isoxaflutole 40 % + Ortho silicic acid 4 %
xi. Topramezone 10% + Pyroxasulfone 30% + Ortho silicic acid 4 %
xii. Topramezone 10% + Pyroxasulfone 30 % + Triacontanol 0.4 %
xiii. Topramezone10%+ Pyroxasulfone 30%+Gibberellic acid 0.4 %

[CLAIM 14]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 1 and claim 13, wherein the Water Dispersible Granule/Wettable Granule (WG) formulation comprises:
i. a herbicide Topramezone present in an amount of 0.1 to 50 % by weight or mixture thereof;
ii. at least one herbicide(s) selected from Halosulfuron methyl, Nicosulfuron, Isoxaflutole, Atrazine, Metribuzin, Pyroxasulfone, Halosulfuron methyl, Pyrazosulfuron ethyl or mixture thereof present in an amount of 0.1 to 50% by weight or mixture thereof;
iii. a plant health additive(s) is selected from Fulvic acid, Ortho silicic acid, Triacontanol, Gibberellic acid or mixture thereof present in an amount of 0.001 to 30% by weight or mixture thereof.
iv. Wetting-spreading-penetrating agent present in an amount of 4 to 10% by weight;
v. Dispersing agent I present in an amount of 2 to 10 % by weight;
vi. Dispersing agent II present in an amount of 2 to 5 % by weight;
vii. Disintegrating agent present in an amount of 4 to 10 % by weight;
viii. Antifoaming agent present in an amount of 0.1 to 1 % by weight;
ix. Carrier present in an amount of 5 to 30 % by weight to make quantity sufficient.

[CLAIM 15]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 14, wherein dispersing agent is selected from naphthalene sulfonic acid, sodium salt condensated with formaldehyde, polyalcoxylated alkylphenol, naphthalenesulfonic acid formaldehyde condensate, methylnaphtaline-formaldehyde-condensate sodium salt, napthalene condensates, lignosulfonates, polyacrylates and phosphate esters, calcium lignosulfonate,lignin sulfonate sodium salt.

[CLAIM 16]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 14, wherein Wetting-spreading-penetrating agent is selected from sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonate, sodium salt, mixture of isomers of dibutyl naphthalene sulphonic acid sodium salt, sodium di-isopropyl naphthalene sulphonate, sodium Lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulphosuccinates and non-ionic such as tridecyl alcohol ethoxylate, alkyl or alkaryl sulfonates such as alkylbenzene sulfonates, alpha olefin sulfonate and alkyl naphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphate esters, alkyl polysaccharide, di or mono alkyl sulfosuccinate derivatives, alpha olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulphosuccinates, butyl, dibutyl, isopropyl and di-isopropyl naphthalene sulfonate salts, C12 alkyl benzene sulfonate or C10-C16 alkyl benzene sulfonate, organosilicons surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, trisiloxane heptamethyl, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof.

[CLAIM 17]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 14, wherein disintegrating agent is selected from citric acid, succinic acid or the sodium bicarbonate.

[CLAIM 18]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 14, wherein carrier is selected from china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulfate, sodium chloride, gypsum, calcium sulfate, pyrophyllite, silicates and silica gels; fertilizers such as, for example, ammonium sulfate, ammonium phosphate, ammonium nitrate and urea; natural products of vegetable origin such as, for example, grain meals and flours, bark meals, wood meals, nutshell meals and cellulosic powders; and synthetic polymeric materials such as, for example, ground or powdered plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers.

[CLAIM 19]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 14, wherein anti-foaming agent is polydimethylsiloxane.

[CLAIM 20]. The synergistic agrochemical composition for reducing phytotoxicity as claimed in claim 1, wherein crop safener for the monocotyledonous crops is selected from the cyprosulfamide, dietholate, isoxadifen / isoxadifen ethyl, dicyclonon, benoxacor, mefenpyr ethyl, fenchlorazole ethyl, cloquintocet / cloquintocet mexyl, oxabetrinil, naphthalic anhydride, mephenate, mefenpyr, furilazole, fluxofenim, flurazole, fenclorim, fenchlorazole, dichlormid, cyometrinil.