DESC:FIELD OF THE INVENTION
[0001] The present disclosure generally relates to the field of agro-chemicals. Specifically, the present disclosure discloses a composition for the protection of plants. More specifically, the present disclosure relates to an herbicidal composition comprising 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole; at least one sulfonylurea herbicide; and at least one additional herbicide.

BACKGROUND OF THE INVENTION
[0002] Background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the present invention, or that any publication specifically or implicitly referenced is prior art.
[0003] Weeds are undesired plants that tend to grow along with crops or pastures. These plants can grow faster than crops and compete with them for light, nutrients, water and space thereby diminishing their growth. Weeds eventually increase production costs and farmers end up wasting their resources on unfruitful plant species. Controlling such undesired weeds is an activity that has thus become essential for all farming practices. Methods of controlling weeds include physical disruption of their growth with equipments including mowing, weed pulling or mulching. Chemical weed control however remains the most effective form of control. In chemical weed control herbicides are applied to weeds or soils to control the growth of weeds.
[0004] Researchers have invented a number of synthetic chemicals and agents that are effective in controlling weeds. Activity of herbicides depends upon the climate, types of weeds, application rate etc. Individual herbicides have a limited scope of activity in terms of weed control. More often, farmers use multiple herbicides in various rounds with different application rates to control the vast spectrum of weeds that may be growing along with the crop. Combination of herbicidal active ingredients can offer a more effective solution for weed control than individual herbicides. However, development of combinations of herbicidal active ingredients is a complex and challenging process. It is essential to establish the biological compatibility of the active ingredients, avoid phyto-toxicity of the crop plants, ensure stability of the combination and avoid herbicide antagonism.
[0005] Thus, there is a need to develop new and improved compositions of herbicidal active ingredients that are compatible, non-phytotoxic for crop plants and provide effective weed control.

OBJECTS OF THE INVENTION
[0006] An object of the present disclosure is to provide an herbicidal composition for weed or undesired plant control.
[0007] An object of the present disclosure is to provide an herbicidal composition that has a broad spectrum of activity against weeds.
[0008] An object of the present disclosure is to provide an herbicidal composition that has synergistic activity.
[0009] An object of the present disclosure is to provide an herbicidal composition that may be employed for weed resistance management.
[0010] An object of the present disclosure is to provide an herbicidal composition that is non-phyto-toxic to crop plants and can improve tiller and shoot count.

SUMMARY OF THE INVENTION
[0011] This summary is provided to introduce a selection of concepts in a simplified form that are further described below in Detailed Description section. This summary is not intended to identify key features or essential features of the subject matter of the present invention, nor is it intended to be used as an aid in determining the scope of the subject matter disclosed herein.
[0012] The present disclosure relates to herbicidal compositions comprising active ingredients with synergistic herbicidal effect against undesirable plants and vegetation.
[0013] In an aspect, the present disclosure provides an herbicidal composition comprising 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole or Pyroxasulfone; at least one sulfonylurea herbicide; and at least one additional herbicide.
[0014] In an embodiment, the sulfonylurea herbicide may be selected from the group comprising of pyrazosulfuron-ethyl, metsulfuron-methyl, halosulfuron-methyl, chlorimuron-ethyl, sulfosulfuron, trifloxysulfuron-sodium or combinations thereof.
[0015] In an embodiment, the additional herbicide may be selected from the group comprising of isoxaflutole, clomazone, sulfentrazone, metribuzin, ametryn, atrazine, diuron, mesotrione, tembotrione, sulcotrione, topramezone, flumioxazin, trifludimoxazin, bicyclopyrone, tolpyralate, 2,4-dichlorophenoxyacetic acid, flufenacet, penoxsulam, diclosulam, pyroxsulam, prosulfocarb, (S)-metolachlor, pendimethalin, or combinations thereof.
[0016] In an aspect, the present disclosure provides an herbicidal formulation comprising 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole; at least one sulfonylurea herbicide; and at least one additional herbicide and one or more auxiliary agent(s), additives recognized in the art of crop protection.
[0017] In an aspect, the present disclosure relates to a process of preparing an herbicidal composition comprising 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole; at least one sulfonylurea herbicide; and at least one additional herbicide.
[0018] In another aspect, the present disclosure relates to a method of controlling growth of undesired plants by application of a herbicidally effective amount of an herbicidal composition or formulation comprising 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole; at least one sulfonylurea herbicide; and at least one additional herbicide.
[0019] In still another aspect, the present disclosure relates to a method of preventing undesired plants to emerge or if they germinate, stop growing and eventually perish by applying a herbicidally effective amount of an herbicidal composition or formulation comprising 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole; at least one sulfonylurea herbicide; and at least one additional herbicide.
[0020] In yet another aspect, the present disclosure relates to use of an herbicidal composition or formulation on unwanted vegetation or plants comprising 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole; at least one sulfonylurea herbicide; and at least one additional herbicide.
[0021] Other aspects of the invention will be set forth in the description which follows, and in part will be apparent from the description, or may be learnt by the practice of the invention.

DETAILED DESCRIPTION OF THE INVENTION
[0022] The following is a detailed description of embodiments of the disclosure. The embodiments are in such detail as to clearly communicate the disclosure. However, the amount of detail offered is not intended to limit the anticipated variations of embodiments; on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the scope of the present disclosure.
[0023] All publications herein are incorporated by reference to the same extent as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. Where a definition or use of a term in an incorporated reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein applies and the definition of that term in the reference does not apply.
[0024] Reference throughout this specification to “one embodiment” or “an embodiment” means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of the phrases “in one embodiment” or “in an embodiment” in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
[0025] In some embodiments, numbers have been used for quantifying weights, percentages, ratios, and so forth, to describe certain embodiments of the invention and are to be understood as being modified in some instances by the term “about.” Accordingly, in some embodiments, the numerical parameters set forth in the written description are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable. The numerical values presented in some embodiments of the invention may contain certain errors necessarily resulting from the standard deviation found in their respective testing measurements.
[0026] Various terms as used herein are shown below. To the extent a term used is not defined below, it should be given the broadest definition persons in the pertinent art have given that term as reflected in printed publications and issued patents at the time of filing.
[0027] As used in the description herein that follow, the meaning of “a,” “an,” and “the” includes plural reference unless the context clearly dictates otherwise. Also, as used in the description herein, the meaning of “in” includes “in” and “on” unless the context clearly dictates otherwise.
[0028] Unless the context requires otherwise, throughout the specification which follow, the word “comprise” and variations thereof, such as, “comprises” and “comprising” are to be construed in an open, inclusive sense that is as “including, but not limited to.”
[0029] The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein.
[0030] All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g. “such as”) provided with respect to certain embodiments herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention.
[0031] Groupings of alternative elements or embodiments of the invention disclosed herein are not to be construed as limitations. Each group member can be referred to individually or in any combination with other members of the group or other elements found herein. One or more members of a group can be included in, or deleted from, a group for reasons of convenience and/or patentability. When any such inclusion or deletion occurs, the specification is herein deemed to contain the group as modified.
[0032] The description that follows, and the embodiments described therein, is provided by way of illustration of an example, or examples, of particular embodiments of the principles and aspects of the present disclosure. These examples are provided for the purposes of explanation, and not of limitation, of those principles and of the disclosure.
[0033] It should also be appreciated that the present disclosure can be implemented in numerous ways, including as a system, a method or a device. In this specification, these implementations, or any other form that the invention may take, may be referred to as processes. In general, the order of the steps of the disclosed processes may be altered within the scope of the invention.
[0034] The headings and abstract of the invention provided herein are for convenience only and do not interpret the scope or meaning of the embodiments.
[0035] The following discussion provides many example embodiments of the inventive subject matter. Although each embodiment represents a single combination of inventive elements, the inventive subject matter is considered to include all possible combinations of the disclosed elements. Thus, if one embodiment comprises elements A, B, and C, and a second embodiment comprises elements B and D, then the inventive subject matter is also considered to include other remaining combinations of A, B, C, or D, even if not explicitly disclosed.
[0036] As described herein, the term ‘herbicidally effective amount of’ is used to imply the amount of the herbicidal composition or formulation that is necessary for the prevention or curb of growth of unwanted or undesired plants and vegetation without causing any toxicity in crop plants. It may be dependent on the time, soil, target weeds, crops and environmental conditions at the time of application.
[0037] The herbicidal composition of the present disclosure is a synergistic composition comprising active ingredients 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole; at least one sulfonylurea herbicide; and at least one additional herbicide.
[0038] 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole or Pyroxasulfone used as an active ingredient is a compound belonging to the family of isoxazolines, it is a pre-emergence grass and broad-leaved weed herbicide and has code ‘K3’as per Herbicide Resistance Action Committee(HRAC) wherein the weedicidal property is due to the inhibition of very long-chain fatty acid synthesis. It has the structure as per Formula I:

Formula I
[0039] In one embodiment, exemplary sulfonylurea herbicide included in the composition is selected from ethyl 5-[(4,6-dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl]-1-methylpyrazole-4-carboxylate; methyl 2-(4-methoxy-6-methyl-1,3,5-triazin-2-ylcarbamoylsulfamoyl)benzoate; methyl 3-chloro-5-(4,6-dimethoxypyrimidin-2-ylcarbamoylsulfamoyl)-1-methylpyrazole-4-carboxylate; ethyl 2-[(4-chloro-6-methoxypyrimidin-2-yl)carbamoylsulfamoyl]benzoate; 1-(4,6-dimethoxypyrimidin-2-yl)-3-(2-ethylsulfonylimidazo[1,2-a]pyridin-3-yl)sulfonylurea; sodium N'-(4,6-dimethoxypyrimidin-2-yl)-N-[3-(2,2,2-trifluoroethoxy)-2-pyridylsulfonyl]imidocarbamate; or combinations thereof.
[0040] Ethyl 5-[(4,6-dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl]-1-methylpyrazole-4-carboxylate is commonly known as pyrazosulfuron-ethyl and inhibits broad-leaved weeds, grasses and sedges by a mode of action involving inhibition of acetolactate synthase. It is coded ‘B’ under HRAC.
[0041] Methyl2-(4-methoxy-6-methyl-1,3,5-triazin-2-ylcarbamoylsulfamoyl)benzoate is commonly known as metsulfuron-methyl and it is classified under the code name ‘B’ as per HRAC.
[0042] Ethyl 2-[(4-chloro-6-methoxypyrimidin-2-yl)carbamoylsulfamoyl]benzoate is commonly known as chlorimuron-ethyl. It is an EC 2.2.1.6 (acetolactate synthase) inhibitor and has a role as a pro-herbicide.
[0043] In one embodiment, at least one additional herbicide comprised in the composition of the present disclosure is selected from (5-cyclopropyl-1,2-oxazol-4-yl)(a,a,a-trifluoro-2-mesyl-p-tolyl)methanone; 2',4'-dichloro-5'-(4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl)methanesulfonanilide; 4-amino-6-tert-butyl-4,5-dihydro-3-methylthio-1,2,4-triazin-5-one; [3-(4,5-dihydro-1,2-oxazol-3-yl)-4-mesyl-o-tolyl](5-hydroxy-1-methylpyrazol-4-yl)methanone; (S)-enantiomer of 2-chloro-N-(2-ethyl-6-methylphenyl)-N-(1-methoxypropan-2-yl)acetamide; or combinations thereof.
[0044] In an embodiment, at least one additional herbicide compound can be selected from clomazone, ametryn, atrazine, diuron, mesotrione, tembotrione, sulcotrione, flumioxazin, trifludimoxazin, bicyclopyrone, tolpyralate, 2,4-dichlorophenoxyacetic acid (2,4 d salt), flufenacet, penoxsulam, diclosulam, pyroxsulam, prosulfocarb, pendimethalin, or combinations thereof.
[0045] (5-cyclopropyl-1,2-oxazol-4-yl)(a,a,a-trifluoro-2-mesyl-p-tolyl)methanone Isoxaflutole is commonly known as isoxazole belonging to the code ‘F2’ of HRAC Classification. It is a broad spectrum pre-emergence herbicide. Its herbicidal activity is because of the inhibition of 4-hydroxyphenyl pyruvate dioxygenase after systemic adsorption by roots and leaves.
[0046] 2',4'-dichloro-5'-(4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl)methanesulfonanilide is commonly known as sulfentrazone. It is a pre-emergence herbicide that has high solubility and volatility. Its mode of action is by inhibition of protoporphyrinogen oxidase and thus falls under code ‘E’ of HRAC classification.
[0047] 4-amino-6-tert-butyl-4,5-dihydro-3-methylthio-1,2,4-triazin-5-one is known as metribuzin. It is a pre and post-emergence herbicide that inhibits photosynthesis at PS II of the target plants and is thus categorized under code ‘C1’ by the HRAC.
[0048] [3-(4,5-dihydro-1,2-oxazol-3-yl)-4-mesyl-o-tolyl](5-hydroxy-1-methylpyrazol-4-yl)methanone is commonly known as topramezone having inhibitory action on hydroxyphenyl pyruvate dioxygenase and is classified under ‘F2’ as per HRAC.
[0049] (S)-enantiomer of 2-chloro-N-(2-ethyl-6-methylphenyl)-N-(1-methoxypropan-2-yl)acetamide is commonly known as S-Metolachlor. It can be used as a post-emergence herbicide on grasses and broadleaf weeds. It belongs to the ‘K3’ classification group of HRAC and shows inhibition of very long-chain fatty acid synthesis.
[0050] The components of the composition as disclosed above may include all their isomers including enantiomers, diastereomers; salts; derivatives and the like.
[0051] In an embodiment, the composition may comprise 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole known as pyroxasulfone in a weight range from about 0.001% to about 90% with respect to the composition. The weight range may be from about 0.001% to about 80%, about 0.001% to about 70%, about 0.01% to about 60%, or about 0.01% to about 50%.
[0052] In an embodiment, the composition may comprise sulfonylurea herbicide in a weight range from about 0.001% to about 90% with respect to the composition. Preferably, the weight range of sulfonylurea may be in the range of about 0.001% to about 80%, about 0.001% to about 70%, about 0.01% to about 60%, or about 0.01% to about 50%.
[0053] In an embodiment, the composition may comprise additional herbicide in a weight range from about 0.001% to about 90% with respect to the composition. Preferably, the weight range may be in the range of about 0.001% to about 80%, about 0.001% to about 70%, about 0.01% to about 60%, or about 0.01% to about 50%.
[0054] In an embodiment, the composition comprises about 0.01% to about 50% of 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole; about 0.01% to about 50% of at least one sulfonylurea herbicide; and about 0.01% to about 50% of at least one additional herbicide.
[0055] The components Pyroxasulfone; at least one sulfonylurea herbicide and at least one additional herbicide are compatible with each other and form stable compositions.
[0056] In an embodiment, the composition shows a synergistic effect in herbicidal activity, wherein the effect of the composition is over and above the effects of the individual components. The composition provides desirable residual control of weeds.
[0057] In an embodiment, the composition slows down the growth or kills the undesired plants.
[0058] In an embodiment, the herbicidal composition may be effective in the control of unwanted vegetation in plantation crops, orchards, fallow lands, water bodies, or field bunds.
[0059] In an embodiment, the herbicidal composition shows broad spectrum activity and upto 99% reduction in undesired plants. In an embodiment, the herbicidal composition shows at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 95% or at least 99% reduction in undesired plants.
[0060] In an embodiment, the composition does not show any significant phytotoxicity for crops, specifically wheat, sugarcane and soybean crop. The composition does not have any kind of negative impact on crop growth.
[0061] In an embodiment, the composition contributes to increase in crop yield, which may be characterized by increase in tiller and shoot counts, larger leaves, increased shoot growth, increased pigment, increased oil content, increased leaf index, plant height, weight or combinations thereof. In an embodiment, the quality of the plant is increased by the composition.
[0062] In an embodiment, the composition can delay, reduce and/or avoid the onset of herbicidal resistance. It can provide a one shot application for the inhibition of growth of undesired plants on a field. The composition even in a single shot application is an excellent control against tough-to-control weeds. This reduces the efforts for farmers.
[0063] In an embodiment, the composition lowers the application rate of active compounds on the undesired plants. Based on the formulation the way of application may be selected from spraying, dusting, scattering, or soaking.
[0064] In an embodiment, the composition has superior storage stability. No change or degradation maybe noted over time.
[0065] In an embodiment, the composition may further comprise one or more agro-chemically acceptable additives or auxiliary agents. The additives may be selected from dispersing agents, suspending agent, anti-freezing agent, fillers, wetting agents, wetting/spreading/penetrating agent, buffering agent, colorants, surfactants, tackifiers, pH regulators, anti-foaming agents, solvents, emulsifiers, solid carriers, disintegrating agents, stabilizer, preservatives, thickeners, humectants, and combinations thereof.
[0066] The composition of the present disclosure may also comprise other active components as additives including insecticides, fertilizers, fungicides, pesticides, or combinations thereof. The composition content of these additives is not particularly limiting and may be determined by a skilled technician in the art according to the conventional protocols.
[0067] In an embodiment, the present disclosure relates to a formulation comprising Pyroxasulfone; at least one sulfonylurea herbicide; at least one additional herbicide and one or more auxiliary agent(s), additives recognized in the art of crop protection.
[0068] The additives may be selected from dispersing agents, suspending agent, anti-freezing agent, fillers, wetting agents, wetting/spreading/penetrating agent, buffering agent, colorants, surfactants, tackifiers, pH regulators, anti-foaming agents, solvents, emulsifiers, solid carriers, disintegrating agents, stabilizer, preservatives, thickeners, humectants, and combinations thereof.
[0069] In an embodiment, the formulation may be a solid, liquid or semi-solid formulation. In an embodiment, the formulation may be selected from the group comprising of capsule suspension (CS), dispersible concentrate (DC), emulsifiable concentrate (EC), emulsion, water in oil (EO), emulsion, oil in water (EW), jambo balls or bags (bags in water soluble pouch), micro-emulsion (ME), oil dispersion (OD), oil miscible flowable concentrate (oil miscible suspension) (OF), oil miscible liquid (OL), suspension concentrate (SC), suspo-emulsion (SE), soluble concentrate (SL), water dispersible granule (WG or WDG), water soluble granule (SG), water soluble powder (SP), wettable powder (WP), a mixed formulation of CS and SC (ZC), a mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), and Controlled release granules (CR).
[0070] In a preferred embodiment, the formulation is a dry formulation selected from water dispersible granule (WG or WDG) or wettable powder (WP).
[0071] In an embodiment, the formulation is a Suspension Concentrate (SC) formulation. The suspension concentrate comprises one or more agro-chemically acceptable additives selected from wetting agent, dispersing agent, suspending agent, anti-foaming agent, anti-freezing agent, preservatives, thickeners, humectants, solvent, or combinations thereof.
[0072] In an embodiment, the wetting agent may be selected from ethylene oxide/propylene oxide block copolymer, polyarylphenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate, sodium dodecyl benzene sulfonate, alkyldiphenylsulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate, organosilicons surfactants (as a wetting-spreading-penetrating agent) includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, or mixtures thereof; each of which may or may not be in modified form, may be liquid or powder form or a mixture thereof.
[0073] In an embodiment, the dispersing agent may be selected from naphthalenesulfonic acid, sodium salt condensated with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide, or mixtures thereof.
[0074] In an embodiment, the suspending agent may be selected from aluminum magnesium silicate, bentonite clay, silica, attapulgite clay, or mixtures thereof.
[0075] In an embodiment, the anti-foaming agent may be selected from silicone oil, silicone compound, C10-C20 saturated fatty acid compounds or C8-C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide, modified polydimethylsiloxane, or mixtures thereof.
[0076] In an embodiment, the anti-freezing agent may be selected from ethylene glycol, propane diols, glycerin, urea, glycols (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, magnesium sulfate heptahydrate, sodium chloride, or mixtures thereof.
[0077] In an embodiment, the preservatives may be selected from 1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, or mixtures thereof.
[0078] In an embodiment, the thickeners may be selected from xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, or mixtures thereof.
[0079] In an embodiment, the humectants may be selected from urea, humic acid, glycerol, lactose, or mixtures thereof.
[0080] In a preferred embodiment, the formulation is a suspension concentrate formulation comprising Pyroxasulfone; at least one sulfonylurea herbicide; at least one additional herbicide; urea; copolymer butanol EO/PO; acrylic graft copolymer; tristryphenole with 16 moles EO; attapulgite clay; polydimethyl siloxane; 1,2- benzisothiazoline-3-one; 1,2-Propylene glycol; xanthan gum; and water.
[0081] In an embodiment, the formulation is a suspo emulsion (SE) formulation. The formulation comprises one or more agro-chemically acceptable additives selected from wetting agent, dispersing agent, suspending agent, anti-foaming agent, anti-freezing agent, buffering agent, wetting/spreading/penetrating agent, preservatives, stabilizers, emulsifier, solvent, thickeners, humectants, or combinations thereof.
[0082] In an embodiment, the solvent may be selected from water, water soluble alcohols, macromolecular alcohol and dihydroxy alcohol ethers. Water soluble alcohol or lower alcohol (1-4 carbon atoms) includes-methanol, ethanol, n-propanol, isopropanol, n-butanol, or tert-butanol. Macromolecular alcohol includes polyethylene glycol, sorbitol, or glucitol. Dihydroxy alcohol ethers include dihydroxy alcohol alkyl ether or dihydroxy alcohol aryl ethers. The examples of dihydroxy alcohol alkyl ether includes ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, di-propylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether, or di-propylene glycol ethyl ether. The dihydroxy alcohol aryl ethers include ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, or, di-propylene glycolphenyl ether. The solvent may also be selected from hydrocarbons including n-pentane, hexane(s), cyclohexane, methylcyclohexane, heptane, isooctane, benzene, toluene, xylene(s), isophorone and ester solvents such as methyloleate, dimethylamide and morpholine amide derivatives of C6-C16 fatty acids, and mono-alkylene carbonates such as ethylene carbonate, propylene carbonate and butylene carbonates, dimethylsulfoxide (DMSO), 2-ethylhexanol and n-butanol, n-alkylpyrrolidones, fatty acid dimethyl esters, fatty acid esters, dibasic esters, aromatic hydrocarbons and/or aliphatic hydrocarbons, one or more dimethylamides, such as C8-dimethylamide, C10-dimethylamide, C12-dimethylamide, ethylene glycol, propylene glycol, polyalkylene glycols, aromatic hydrocarbons, methylpyrrolidinone (NMP); dimethylformamide (DMF); dimethylisosorbide (DMI); isophorone; acetophenone; 1,3-dimethyl-2-imidazolidonone; lactate esters; dimethyl and diethylcarbonates; methyl L-lactate, 2-ethylhexyl L-lactate, ethyl L-lactate, n-butyl L-lactate, or octyl phenol ethoxylates. Any of the mentioned solvent can be used either alone or in combination.
[0083] In an embodiment, the emulsifier may be selected from emulsifiers containing salts of dodecylbenzene sulphonate, e.g. Ca-salts or amine salts, and sulphonates of other C11-C16 alkylbenzenes, alkylether sulphates, alkyl phenol ether phosphates and ester phosphates; non-ionic surfactants such as alkoxylated alcohols and alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, e.g. ethoxylated castor oil, fatty acid esters, e.g. sorbitol, and their ethoxylated derivatives, ethoxylated amines, and condensates of glycerol; and catanionic emulsifiers such as a cationic amine, optionally in combination with an alkylsulphonate or ether sulphonate or ether phosphate, alkoxylated alcohols; alkoxylated alkylphenols; ethoxylated fatty acids; ethoxylated vegetable oils; ethoxylated tristyrylphenol (tristyrlphenol with 16 moles EO), tristyrylphenol-polyglycolether-phosphate, fatty acid esters of sorbitol and ethoxylated derivatives thereof; ethoxylated amines and condensates of glycerol; sulfonated alkylbenzenes in the range C11-C16 and salts thereof; alkylether sulphates; alkyl ether phosphates; alkyl phenol ether phosphates; or combinations thereof; salts of phosphate esters of ethoxylated tristyrylphenol; salts of sulphated ethers of ethoxylated tristyrylphenol; or a catanionic system, wherein a cationic amine is present in combination with an alkyl sulphonate, an alkyl ether sulphonate, an ether sulphate, or an ether phosphate such as an alkyl ether phosphate, nonylphenol polyethoxyethanols, castor oil polyglycol ethers, polyadducts of ethylene oxide and polypropylene, tributyl phenoxy polyethoxy ethanol, octyl phenoxy polyethoxy ethanol, or mixtures thereof.
[0084] In an embodiment, the stabilizer may be selected from butylated hydroxytoluene (BHT), epoxidized soybean oil (ESBO), and epichlorhydrin.
[0085] In an embodiment, the anti-freezing agent may be selected from ethylene glycol, propane diols, glycerine, urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerine, urea, magnesium sulfate heptahydrate, sodium chloride, or mixtures thereof. In an embodiment, the anti-foaming agent may be selected from silicone oil, silicone compound, C10-C20 saturated fatty acid compounds or C8-C10 aliphatic alcohols, silicone antifoam emulsion, dimethylsiloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane, or mixtures thereof.
[0086] In an embodiment, the suspending agent may be selected from aluminum magnesium silicate, bentonite clay, silica, silicone dioxide, attapulgite clay, or mixtures thereof. In an embodiment, the wetting agent may be selected from ethylene oxide/propylene oxide block copolymer, polyarylphenyl ether phosphate, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulphate, sodium dodecyl benzene sulfonate, alkyl diphenylsulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate, octyl phenol ethoxylate, alkyl phenol ethoxylate, or combinations thereof.
[0087] In an embodiment, the wetting agent may be selected from organosilicone surfactants including trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, polyalkyleneoxide modified heptamethyl trisiloxane, heptamethyl trisiloxane ethoxylate, polyether modified polysiloxane, 10 mole ethylene oxide adduct of octylphenol, or mixtures thereof. Each of these may or may not be in modified form, may be liquid or powder form or mixture thereof.
[0088] In an embodiment, the preservative may be selected from propionic acid and its sodium salt, sorbic acid and its sodium or potassium salt, benzoic acid and its sodium salt, p-hydroxy benzoic acid sodium salt; methyl p-hydroxy benzoate; and biocide such as sodium benzoate, 1,2-benzisothiazoline-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2- methyl-4-isothiazolin-3-one, potassium sorbate, parahydroxy benzoates or mixtures thereof. In an embodiment, the thickeners may be selected from water-insoluble particulates and water-soluble polymers. It is possible to produce suspo-emulsion formulations using clays and silicas. Examples of these types of materials, include, but are limited to, montmorillonite, e.g. bentonite; magnesium aluminum silicate; and attapulgite. Water-soluble polysaccharides have been used as thickening-gelling agents for many years. The types of polysaccharides most commonly used are natural extracts of seeds and seaweeds are synthetic derivatives of cellulose or mixtures thereof. Examples of these types of materials include, but are not limited to, guar gum; locust bean gum; carrageenam; xanthan gum; alginates; methyl cellulose; sodium carboxymethyl cellulose (SCMC); hydroxyethyl cellulose (HEC) or mixtures thereof. Other types of thickeners are based on modified starches, polyacrylates, polyvinyl 20 alcohol and polyethylene oxide or mixtures.
[0089] In an embodiment, the buffering agent may be selected from the group comprising of calcium hydroxyapatite, potassium dihydrogen phosphate, sodium hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphates, carbonated calcium phosphates, amine monomers, lactate dehydrogenase and magnesium hydroxide. In an embodiment, the humectant may be selected from urea, humic acid, glycerol, lactose, or mixtures thereof.
[0090] In a preferred embodiment, the formulation is a suspo-emulsion formulation comprising Pyroxasulfone; at least one sulfonylurea herbicide; at least one additional herbicide; urea; octyl phenol ethoxylate; aromatic solvent; castor oil ethoxylate; copolymer butanol EO/PO; acrylic graft copolymer; tristryphenole with 16 moles EO; attapulgite clay; polydimethyl siloxane; 1,2- benzisothiazoline-3-one; 1,2-propylene glycol; xanthan gum; and water.
[0091] In an embodiment, the formulation is a Wettable Granule (WG) or Water Dispersible Granule (WDG) formulation. The wettable granule or water dispersible granule comprises one or more agro-chemically acceptable additives selected from wetting agent, dispersing agent, anti-foaming agent, carrier, disintegrating agent, humectants, natural products of vegetable origin, fertilizers, synthetic polymeric materials or combinations thereof.
[0092] In an embodiment, the wetting agent may be selected from sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonate, sodium salt, mixture of isomers of dibutylnaphthalene sulphonic acid sodium salt, sodium di-isopropylnaphthalene sulphonate, sodium lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulphosuccinates and non-ionic such as tridecyl alcohol ethoxylate, alkyl or alkaryl sulfonates such as alkylbenzene sulfonates, alpha olefin sulfonate and alkyl naphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphate esters, alkyl polysaccharide, di or mono alkyl sulfosuccinate derivatives, alpha olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulphosuccinates, butyl, dibutyl, isopropyl and di-isopropyl naphthalene sulfonate salts, C12 alkyl benzene sulfonate or C10-C16 alkyl benzene sulfonate, organosilicons surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, trisiloxaneheptamethyl, polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, or mixtures thereof. Each of these may or may not be in modified form, may be liquid or powder form or mixture thereof.
[0093] In an embodiment, the dispersing agent may be selected from alkylnaphthalene sulfonate sodium salt, sodium polycarboxylate, naphthalenesulfonic acid, sodium salt condensates with formaldehyde, polyalcoxylated alkylphenol, naphthalenesulfonic acid formaldehyde condensate, methylnaphthalene-formaldehyde-condensate sodium salt, naphthalene condensates, lignosulfonates, polyacrylates, phosphate esters, calcium lignosulfonate, lignin sulfonate sodium salt, or mixtures thereof.
[0094] In an embodiment, the anti-foaming agent may be polydimethylsiloxane. In an embodiment, the carrier may be selected from china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates, or silica gels; fertilizers such as, for example, ammonium sulphate, ammonium phosphate, ammonium nitrate and urea; natural products of vegetable origin such as, for example, grain meals and flours, bark meals, wood meals, nutshell meals and cellulosic powders; and synthetic polymeric materials such as, for example, ground or powdered plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers, or mixtures thereof. In an embodiment, the disintegrating agent may be selected from citric acid, succinic acid or the sodium bicarbonate. In an embodiment, the humectant may be urea, humic acid, glycerol, lactose, or mixtures thereof.
[0095] In a preferred embodiment, the formulation is a wettable granule (WG) formulation comprising Pyroxasulfone; at least one sulfonylurea herbicide; at least one additional herbicide; alkylated naphthalene sulfonate, sodium salt; polyacrylate polymer sodium salt, sodium alkyl naphthalene sulfonate blend, silicone antifoam, sodium sulfate anhydrous, corn starch, water, and china clay.
[0096] In a preferred embodiment, the formulation is a wettable powder (WP) formulation comprising Pyroxasulfone; at least one sulfonylurea herbicide; at least one additional herbicide; alkylated naphthalene sulfonate, sodium salt; polyacrylate polymer sodium salt; copolymer butanol EO/PO; sodium alkyl naphthalene sulfonate blend; silicone antifoam; sodium sulfate anhydrous; silica; water and china clay.
[0097] In an embodiment, the formulation may be a suspo-emulsion (SE) formulation comprising:
(a) Pyroxasulfone in a weight percentage of about 2.5%; Sulfosulfuron in a weight percentage of about 0.5%; and Pendimethalin in a weight percentage of about 15% of the formulation;
(b) Pyroxasulfone in a weight percentage of about 2.5%; Sulfosulfuron in a weight percentage of about 0.5%; and S-metolachlor in a weight percentage of about 15% of the formulation;
(c) Pyroxasulfone in a weight percentage of about 8%; Sulfosulfuron in a weight percentage of about 1.6%; and Metribuzin in a weight percentage of about 5% of the formulation;
(d) Pyroxasulfone in a weight percentage of about 8%; Sulfosulfuron in a weight percentage of about 1.6%; and Flufenacet in a weight percentage of about 8% of the formulation;
(e) Pyroxasulfone in a weight percentage of about 2.5%; Metsulfuron methyl in a weight percentage of about 0.1%; and Pendimethalin in a weight percentage of about 15% of the formulation;
(f) Pyroxasulfone in a weight percentage of about 2.5%; Metsulfuron methyl in a weight percentage of about 0.1%; and S-metolachlor in a weight percentage of about 15% of the formulation;
(g) Pyroxasulfone in a weight percentage of about 8%; Metsulfuron methyl in a weight percentage of about 0.32%; and Metribuzin in a weight percentage of about 5% of the formulation; or
(h) Pyroxasulfone in a weight percentage of about 8%; Metsulfuron methyl in a weight percentage of about 0.32%; and Flufenacet in a weight percentage of about 8% of the formulation.
[0098] In an embodiment, the formulation may be a wettable granule or water dispersible granule (WG) formulation comprising:
(a) Pyroxasulfone in a weight percentage of about 30%; Metsulfuron methyl in a weight percentage of about 1%; and Isoxaflutole in a weight percentage of about 30% of the formulation;
(b) Pyroxasulfone in a weight percentage of about 12%; Metsulfuron methyl in a weight percentage of about 0.4%; and Sulfentrazone in a weight percentage of about 50% of the formulation;
(c) Pyroxasulfone in a weight percentage of about 8%; Metsulfuron methyl in a weight percentage of about 0.24%; and Ametryn in a weight percentage of about 66.67% of the formulation;
(d) Pyroxasulfone in a weight percentage of about 8%; Metsulfuron methyl in a weight percentage of about 0.24%; and Atrazine in a weight percentage of about 66.67% of the formulation;
(e) Pyroxasulfone in a weight percentage of about 40%; Trifloxysulfuron sodium in a weight percentage of about 13.33%; and Diclosulam in a weight percentage of about 8% of the formulation;
(f) Pyroxasulfone in a weight percentage of about 24%; Trifloxysulfuron sodium in a weight percentage of about 8%; and Mesotrione in a weight percentage of about 20% of the formulation;
(g) Pyroxasulfone in a weight percentage of about 24%; Trifloxysulfuron sodium in a weight percentage of about 8%; and Tembotrione in a weight percentage of about 10% of the formulation;
(h) Pyroxasulfone in a weight percentage of about 24%; Trifloxysulfuron sodium in a weight percentage of about 8%; and Topramezone in a weight percentage of about 4% of the formulation;
(i) Pyroxasulfone in a weight percentage of about 24%; Trifloxysulfuron sodium in a weight percentage of about 8%; and Flumioxazin in a weight percentage of about 20% of the formulation;
(j) Pyroxasulfone in a weight percentage of about 40%; Chlorimuron ethyl in a weight percentage of about 3%; and Diclosulam in a weight percentage of about 8% of the formulation; or
(k) Pyroxasulfone in a weight percentage of about 4%; Chlorimuron ethyl in a weight percentage of about 0.3%; and Sulfentrazone in a weight percentage of about 20% of the formulation.
[0099] In an embodiment, the formulation may be a wettable powder (WP) formulation comprising Pyroxasulfone in a weight percentage of about 4%; Chlorimuron ethyl in a weight percentage of about 0.3%; and Clomazone in a weight percentage of about 20% of the formulation.
[00100] In an embodiment, the formulation may be a suspension concentrate (SC) formulation comprising:
(a) Pyroxasulfone in a weight percentage of about 10%; Halosulfuron methyl in a weight percentage of about 4%; and Mesotrione in a weight percentage of about 10% of the formulation;
(b) Pyroxasulfone in a weight percentage of about 10%; Halosulfuron methyl in a weight percentage of about 4%; and Tembotrione in a weight percentage of about 5% of the formulation;
(c) Pyroxasulfone in a weight percentage of about 10%; Halosulfuron methyl in a weight percentage of about 4%; and Topramezone in a weight percentage of about 2% of the formulation;
(d) Pyroxasulfone in a weight percentage of about 10%; Halosulfuron methyl in a weight percentage of about 4%; and Flumioxazin in a weight percentage of about 10% of the formulation; or
(e) Pyroxasulfone in a weight percentage of about 16.67%; Halosulfuron methyl in a weight percentage of about 6.67%; and Tolpyralate in a weight percentage of about 5% of the formulation.
[00101] In an embodiment, the formulation may be a mixed CS and SC (ZC) formulation comprising Pyroxasulfone in a weight percentage of about 4%; Metsulfuron methyl in a weight percentage of about 0.133%; and Clomazone in a weight percentage of about 20% of the formulation.
[00102] In a preferred embodiment, the formulation may be selected from one of the following:

Pyroxasulfone (A) Sulfonylurea herbicide
(B) Additional herbicide
(C) Active ingredients (%) Formulation
A B C Strength (%) Type
Pyroxasulfone Sulfosulfuron Pendimethalin 2.5 0.5 15 18.00 SE
Pyroxasulfone Sulfosulfuron S-metolachlor 2.5 0.5 15 18.00 SE
Pyroxasulfone Sulfosulfuron Metribuzin 8 1.6 5 14.60 SE
Pyroxasulfone Sulfosulfuron Flufenacet 8 1.6 8 17.60 SE
Pyroxasulfone Metsulfuron methyl Pendimethalin 2.5 0.1 15 17.60 SE
Pyroxasulfone Metsulfuron methyl S-metolachlor 2.5 0.1 15 17.60 SE
Pyroxasulfone Metsulfuron methyl Metribuzin 8 0.32 5 13.32 SE
Pyroxasulfone Metsulfuron methyl Flufenacet 8 0.32 8 16.32 SE
Pyroxasulfone Metsulfuron methyl Pyroxsulam 40 1.6 4 45.60 WG
Pyroxasulfone Metsulfuron methyl Penoxsulam 40 1.6 4 45.60 WG
Pyroxasulfone Metsulfuron methyl Diclosulam 40 1.6 4 45.60 WG
Pyroxasulfone Metsulfuron methyl Isoxaflutole 30 1 30 61.00 WG
Pyroxasulfone Metsulfuron methyl Clomazone 4 0.133 20 24.13 ZC
Pyroxasulfone Metsulfuron methyl Sulfentrazone 12 0.4 50 62.40 WG
Pyroxasulfone Metsulfuron methyl Ametryn 8 0.24 66.67 74.91 WG
Pyroxasulfone Metsulfuron methyl Atrazine 8 0.24 66.67 74.91 WG
Pyroxasulfone Metsulfuron methyl Diuron 8 0.24 66.67 74.91 WG
Pyroxasulfone Metsulfuron methyl Mesotrione 24 0.8 20 44.80 WG
Pyroxasulfone Metsulfuron methyl Tembotrione 24 0.8 20 44.80 WG
Pyroxasulfone Metsulfuron methyl Topramezone 24 0.8 4 28.80 WG
Pyroxasulfone Metsulfuron methyl Flumioxazin 24 0.8 20 44.80 WG
Pyroxasulfone Metsulfuron methyl Trifludimoxazin 24 0.8 20 44.80 WG
Pyroxasulfone Metsulfuron methyl 2,4-D salt 6 0.2 50 56.20 WG
Pyroxasulfone Metsulfuron methyl Prosulfocarb 4 0.133 50 54.13 EC
Pyroxasulfone Metsulfuron methyl Bicyclopyrone 4 0.133 30 34.13 EC
Pyroxasulfone Pyrazosulfuron ethyl Flufenacet 20 8 30 58.00 WG
Pyroxasulfone Pyrazosulfuron ethyl Pyroxsulam 40 16 4 60.00 WG
Pyroxasulfone Pyrazosulfuron ethyl Penoxsulam 40 16 4 60.00 WG
Pyroxasulfone Pyrazosulfuron ethyl Diclosulam 40 16 4 60.00 WG
Pyroxasulfone Pyrazosulfuron ethyl Isoxaflutole 24 8 25 57.00 WG
Pyroxasulfone Pyrazosulfuron ethyl Clomazone 12 4 50 66.00 WG
Pyroxasulfone Pyrazosulfuron ethyl Sulfentrazone 12 4 50 66.00 WG
Pyroxasulfone Pyrazosulfuron ethyl Ametryn 8 2.67 66.67 77.34 WG
Pyroxasulfone Pyrazosulfuron ethyl Atrazine 8 2.67 66.67 77.34 WG
Pyroxasulfone Pyrazosulfuron ethyl Diuron 8 2.67 2.67 13.34 WG
Pyroxasulfone Pyrazosulfuron ethyl Mesotrione 24 8 20 52.00 WG
Pyroxasulfone Pyrazosulfuron ethyl Tembotrione 24 8 20 52.00 WG
Pyroxasulfone Pyrazosulfuron ethyl Topramezone 24 8 4 36.00 WG
Pyroxasulfone Pyrazosulfuron ethyl Flumioxazin 24 8 20 52.00 WG
Pyroxasulfone Pyrazosulfuron ethyl Trifludimoxazin 24 8 20 52.00 WG
Pyroxasulfone Pyrazosulfuron ethyl 2,4-D salt 6 2 50 58.00 WG
Pyroxasulfone Pyrazosulfuron ethyl Prosulfocarb 4 1.33 50 55.33 EC
Pyroxasulfone Pyrazosulfuron ethyl Bicyclopyrone 4 1.33 30 35.33 EC
Pyroxasulfone Halosulfuron methyl Flufenacet 20 8 30 58.00 WG
Pyroxasulfone Halosulfuron methyl Pyroxsulam 40 16 4 60.00 WG
Pyroxasulfone Halosulfuron methyl Penoxsulam 40 16 4 60.00 WG
Pyroxasulfone Halosulfuron methyl Diclosulam 40 16 4 60.00 WG
Pyroxasulfone Halosulfuron methyl Isoxaflutole 24 8 25 57.00 WG
Pyroxasulfone Halosulfuron methyl Clomazone 12 4 50 66.00 WG
Pyroxasulfone Halosulfuron methyl Sulfentrazone 12 4 50 66.00 WG
Pyroxasulfone Halosulfuron methyl Ametryn 8 2.67 66.67 77.34 WG
Pyroxasulfone Halosulfuron methyl Atrazine 8 2.67 66.67 77.34 WG
Pyroxasulfone Halosulfuron methyl Diuron 8 2.67 2.67 13.34 WG
Pyroxasulfone Halosulfuron methyl Mesotrione 10 4 10 24.00 SC
Pyroxasulfone Halosulfuron methyl Tembotrione 10 4 5 19.00 SC
Pyroxasulfone Halosulfuron methyl Topramezone 10 4 2 16.00 SC
Pyroxasulfone Halosulfuron methyl Flumioxazin 10 4 10 24.00 SC
Pyroxasulfone Halosulfuron methyl Trifludimoxazin 24 8 20 52.00 WG
Pyroxasulfone Halosulfuron methyl Tolpyralate 16.67 6.67 5 28.34 SC
Pyroxasulfone Halosulfuron methyl 2,4-D salt 6 2 50 58.00 WG
Pyroxasulfone Halosulfuron methyl Prosulfocarb 4 1.33 50 55.33 EC
Pyroxasulfone Halosulfuron methyl Bicyclopyrone 4 1.33 30 35.33 EC
Pyroxasulfone Trifloxysulfuron sodium Flufenacet 20 8 30 58.00 WG
Pyroxasulfone Trifloxysulfuron sodium Pyroxsulam 40 16 4 60.00 WG
Pyroxasulfone Trifloxysulfuron sodium Penoxsulam 40 16 4 60.00 WG
Pyroxasulfone Trifloxysulfuron sodium Diclosulam 40 13.33 8 61.33 WG
Pyroxasulfone Trifloxysulfuron sodium Isoxaflutole 24 8 25 57.00 WG
Pyroxasulfone Trifloxysulfuron sodium Clomazone 12 4 50 66.00 WG
Pyroxasulfone Trifloxysulfuron sodium Sulfentrazone 12 4 50 66.00 WG
Pyroxasulfone Trifloxysulfuron sodium Ametryn 8 2.67 66.67 77.34 WG
Pyroxasulfone Trifloxysulfuron sodium Atrazine 8 2.67 66.67 77.34 WG
Pyroxasulfone Trifloxysulfuron sodium Diuron 8 2.67 2.67 13.34 WG
Pyroxasulfone Trifloxysulfuron sodium Mesotrione 24 8 20 52.00 WG
Pyroxasulfone Trifloxysulfuron sodium Tembotrione 24 8 10 42.00 WG
Pyroxasulfone Trifloxysulfuron sodium Topramezone 24 8 4 36.00 WG
Pyroxasulfone Trifloxysulfuron sodium Flumioxazin 24 8 20 52.00 WG
Pyroxasulfone Trifloxysulfuron sodium Trifludimoxazin 24 8 20 52.00 WG
Pyroxasulfone Trifloxysulfuron sodium 2,4-D salt 6 2 50 58.00 WG
Pyroxasulfone Trifloxysulfuron sodium Prosulfocarb 4 1.33 50 55.33 EC
Pyroxasulfone Trifloxysulfuron sodium Bicyclopyrone 4 1.33 30 35.33 EC
Pyroxasulfone Chlorimuron ethyl Flufenacet 20 1.5 30 51.50 WG
Pyroxasulfone Chlorimuron ethyl Pyroxsulam 40 3 4 47.00 WG
Pyroxasulfone Chlorimuron ethyl Penoxsulam 40 3 4 47.00 WG
Pyroxasulfone Chlorimuron ethyl Diclosulam 40 3 8 51.00 WG
Pyroxasulfone Chlorimuron ethyl Isoxaflutole 20 1.5 25 46.50 WG
Pyroxasulfone Chlorimuron ethyl Clomazone 4 0.3 20 24.30 WP
Pyroxasulfone Chlorimuron ethyl Sulfentrazone 4 0.3 20 24.30 WG
Pyroxasulfone Chlorimuron ethyl Ametryn 8 0.6 66.67 75.27 WG
Pyroxasulfone Chlorimuron ethyl Atrazine 8 0.6 66.67 75.27 WG
Pyroxasulfone Chlorimuron ethyl Diuron 8 0.6 2.67 11.27 WG
Pyroxasulfone Chlorimuron ethyl Mesotrione 24 1.8 20 45.80 WG
Pyroxasulfone Chlorimuron ethyl Tembotrione 24 1.8 20 45.80 WG
Pyroxasulfone Chlorimuron ethyl Topramezone 24 1.8 4 29.80 WG
Pyroxasulfone Chlorimuron ethyl Flumioxazin 24 1.8 20 45.80 WG
Pyroxasulfone Chlorimuron ethyl Trifludimoxazin 24 1.8 20 45.80 WG
Pyroxasulfone Chlorimuron ethyl 2,4-D salt 6 0.45 50 56.45 WG
Pyroxasulfone Chlorimuron ethyl Prosulfocarb 4 0.3 50 54.30 EC
Pyroxasulfone Chlorimuron ethyl Bicyclopyrone 4 0.3 30 34.30 EC

[00103] In an embodiment, the present disclosure relates to a process of preparing the herbicidal composition comprising Pyroxasulfone; at least one sulfonylurea herbicide; and at least one additional herbicide. Any process well known to a person of skill in the art may be employed to prepare the composition.
[00104] In an embodiment, the process may comprise the steps of milling, blending, grinding, drying, packaging, extruding, and combinations thereof.
[00105] In an embodiment, the process comprises the steps of: (a) homogenizing by mixing Pyroxasulfone, sulfonylurea herbicide; and additional herbicide; (b) grinding the mixture of step (a); (c) optionally extruding the ground mixture; and (d) formulating into desired formulation.
[00106] In an embodiment, the composition is a water dispersible granule (WG) formulation and is prepared by extrusion or spray drying.
[00107] In an embodiment, preparation by extrusion comprises the steps of: (a) charging and homogenizing required quantity of filler(s), wetting agent(s), dispersing agent(s), suspending agent(s), Pyroxasulfone, sulfonylurea herbicide and additional herbicide in premixing blender; (b) grinding through a jet mill or air classifier mill followed by blending in a post blender to get homogenous mixture; (c)mixing with water to form an extrudable dough; (d) extruding through an extruder to give wet granules; and (e)passing wet granules through fluidized bed drier followed by grading using screens to give the formulation.
[00108] In an embodiment, preparation by spray drying comprises the steps of: (a) homogenizing water, wetting agent, dispersing agent, antifoam and suspending agents in a high shear homogenizer; (b) adding Pyroxasulfone, sulfonylurea herbicide and additional herbicide to get a uniform slurry; (c) grinding in a bead mill till desired size is achieved; and (d) spraying drying at a set temperature to give the formulation.
[00109] In another embodiment, the present disclosure relates to a method of controlling growth of undesired plants by application of a herbicidally effective amount of an herbicidal composition or formulation comprising Pyroxasulfone; at least one sulfonylurea herbicide; and at least one additional herbicide.
[00110] In still another embodiment, the present disclosure relates to a method of preventing undesired plants from infecting crops by applying a herbicidally effective amount of an herbicidal composition or formulation comprising Pyroxasulfone; at least one sulfonylurea herbicide; and at least one additional herbicide.
[00111] In yet another embodiment, the present disclosure relates to use of an herbicidal composition or formulation on unwanted vegetation or plants comprising Pyroxasulfone; at least one sulfonylurea herbicide; and at least one additional herbicide.
[00112] In an embodiment, the composition or formulation may be used for the control of the growth, proliferation or germination of weeds. The synergistic composition broadens the spectrum of undesired plants controlled. In an embodiment, the herbicidal composition of present disclosure controls all kinds of monocots, dicots and sedges weeds. The composition also controls annual and perennial weeds. The most common weeds controlled by the composition include, but are not limited to, Abutilon indicum, Acalypha indica, Acanthospermum hispidum, Achyranthes aspera, Aerva tomentosa, Ageratum conyzoides, Alhagi camelorum, Amaranthus hybridus, Amaranthus spinosus, Amaranthus viridis, Ammannia baccifera, Anagallis arvensis, Argemone mexicana, Artemisia nilagiricia, Asphodelus tenuifolius, Avena fatua, Avena ludoviciana, Bidens pilosa, Boerhaavia diffusa, Boerhavia repanda, Brachiaria mutica, Brassica kaber, Bromus tectorum, Calotropis gigantea, Cannabis sativa, Carthamus axyacantha, Cassia tora, Celosia argentea, Centella asiatica, Chenopodium album, Chenopodium murale, Chloris barbata, Chrozophora rottlerii, Cichorium intybus, Cirsium arvense, Clitoria ternatea, Cnicus arvensis, Commelina benghalensis, Commelina communis, Convolvulus arvensis, Conyza canadensis, Corchorus acutangulus, Coronopus didymus, Crotalaria serice, Cucumis callosus, Cuscuta campestris, Cuscuta chinensis, Cynodon dactylon, Cyanotis axillaris, Cyperus esculenthus, Cyperus iria, Cyperus rotundus, Dactyloctenium aegyptium, Datura stramonium, Daucus carota, Digera arvensis, Digitaria sanguinalis, Dinebra retroflexa, Echinochola colonum, Echinochola crus galli, Eclipta alba, Eichhornia crassipes, Elephantopus scaber, Eleusine indica, Eragrostis major, Euphorbia geniculata, Euphorbia hirta, Fimbristylis miliacea, Fumaria indica, Gynandropsis gynandra, Heliotropium indicum, Indigofera glandulosa, Ipomea aquatica, Lantana camara, Lathyrus aphaca, Launaea asplenifolia, Launaea nudicaulis, Leucas aspera, Ludwigia parviflora, Marsilea quadrifoliata, Medicago denticulate, Mimosa pudica, Melilotus alba, Melilotus indica, Ocimum canum, Oenothera biennis, Opuntia dillenil, Orobanche ramosa, Oryza longistaminata, Oryza sativa, Oxalis corniculata, Oxalis latifolia, Parthenium hysterophorus, Paspalum sanguinale, Phalaris minor, Phyllanthus niruri, Physalis minima, Polypogon monspeliensis, Portulaca oleracea, Prosopis juliflora, Rumex dentatus, Saccharum spontaneum, Stearia glauca, Seteria viridis, Sida spinosa, Silene antirrhina, Sisymbrium irio, Solanum nigrum, Solanum surattense, Sonchus oleraceous, Sorghum halepense, Spergula arvensis, Sphenoclea zeylanica Gaertn, Striga asiatica, Tagetes minuta, Trianthema monogyna, Trianthema portulacastrum, Tribulus terrestris, Trigonelia polycerata, Vernonia cinerea, Vicia sativa, or Xanthium strumarium.
[00113] In an embodiment, the composition or formulation comprising the same slows down the growth or kills the undesired plants.
[00114] In an embodiment, the composition or formulation comprising the same may be suitable for use against a host of crop plants. In an embodiment, the composition or formulation comprising the same may be used to control the target weeds among the field crops GMO (Genetically Modified Organism) and Non GMO varieties of, including but not limited to, Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor),Oat (Avena sativa), Pearl millet (Pennisetum glaucum),Sugarcane (Saccharum officinarum), Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus) , Mustard (Brassica juncea), Rape seed (Brassica napus), Linseed (Linum usitatissimum), Sesame (Sesamum indicum), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.),Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapasubsprapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Litchi (Litchi chinensis), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum) , Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum), Ajwain (Trachyspermum ammi), Psyllium (Plantago ovate), Black Pepper (Piper nigrum), Stevia (Stevia rebaudiana), Safed musli (Chlorophytum tuberosum), Drum stick (Moringa oleifera), Coconut (Coco nucifera), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold (Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera (Gerbera jamesonii), or Carnation (Dianthus caryophyllus).
[00115] In an embodiment, the herbicidal composition or formulation comprising the same may be effective in the control of unwanted vegetation in plantation crops, orchards, fallow lands, water bodies, and field bunds. The composition or formulation is non-phyto-toxic to crop plants.
[00116] In an embodiment, the composition or formulation in accordance with the present disclosure may be applied via tank mix method or sequential application. The composition may be used pre-emergence or post-emergence of undesired plants. It may be applied on the locus of the plant, including all plant parts, or on the soil or turf of growth. It may be applied before or after the crop seeds are planted.
[00117] While the foregoing describes various embodiments of the disclosure, other and further embodiments of the disclosure may be devised without departing from the basic scope thereof. The invention is not limited to the described embodiments, versions or examples, which are included to enable a person having ordinary skill in the art to make and use the invention when combined with information and knowledge available to the person having ordinary skill in the art.
EXAMPLES
[00118] The disclosure will now be illustrated with working examples, which is intended to illustrate the working of disclosure and not intended to take restrictively to imply any limitations on the scope of the present disclosure. Although methods and materials similar or equivalent to those described herein can be used in the practice of the disclosed methods and compositions, the exemplary methods, devices and materials are described herein. It is to be understood that this disclosure is not limited to particular methods, and experimental conditions described, as such methods and conditions may vary.
[00119] EXAMPLE 1 – A suspo-emulsion(SE) formulation
[00120] A 100L suspo-emulsion formulation was prepared with components as per Table 1. 2% gum solution was prepared by charging 2 kg xanthan gum and 2 kg 1,2-benzisothiazoline-3-one into 96 kg water and homogenizing 12-18 hours prior to use. Charged 30 kg of DM water, 5 kg of 1,2-propylene glycol and 5 kg of urea into designated vessel and mixed thoroughly. Added 1 kg of Attapulgite clay, 1.5 kg of copolymer butanol EO/PO, 2.0 kg of acrylic graft copolymer and 0.15 kg of polydimethylsiloxane into the vessel having water and homogenized the contents for 45 – 60 minutes using high shear homogenizer. Then added 2.5 kg of Pyroxasulfone technical and 0.50 kg of Sulfosulfuron technical to this premix slowly and homogenized to get uniform slurry ready for grinding. Before grinding half the quantity of antifoam was added and then material was subjected to grinding in Dyno mill till desired particle size was achieved. Added remaining 0.15 kg of polydimethyl siloxane antifoam after grinding process completed and before sampling for in process analysis to give SC premix. Charged 15 kg of Pendimethalin technical into 10 kg C10-13 aromatic hydrocarbon and 10 kg of octyl phenol ethoxylate and heated at 60 degree and then added 3 kg of tristyrylphenol with 16 moles of EO and mixed properly to give EC premix.
[00121] Then mixed SC and EC premix slowly into other vessel and finally added 8.9 kg of 2% gum solution to this formulation to give the suspo-emulsion formulation.
Table 1: Suspo-emulsion (SE) formualtion
Ingredients Percent (w/w)
Pyroxasulfone a.i. 2.50
Sulfosulfuron a.i. 0.50
Pendimethalin a.i. 15.00
Urea 5.00 Humectant
Octyl phenol ethoxylate 10.00 Solvent
Aromatic solvent 10.00 Co-Solvent
Castor oil ethoxylate 40 moles 5.00 Emulsifier
Copolymer butanol EO/PO 1.50 Wetting agent
Acrylic graft copolymer 2.00 Dispersing agent 1
Tristyrylphenol with 16 moles EO 3.00 Dispersing agent 2
Attapulgite clay 1.00 Suspending agent
Polydimethyl siloxane 0.30 Antifoaming agent
1,2- benzisothiazoline-3-one 0.15 Preservative
1,2-Propylene glycol 5.00 Antifreezing agent
Xanthan gum 0.15 Thickener
Water 38.90 Diluent Water
Total 100.00

[00122] Storage stability of the suspo-emulsion formulation was also studied and the results are provided in Table 2 below. Results indicate the formulation is stable over long periods of time.
Table 2: Storage stability of suspo-emulsion formulation
Laboratory storage for 14 days
Parameters Specification (in house) Initial At 54±2 0C At 0±2 0C
Pyroxasulfone content percent by mass 2.375 to 2.75 2.55 2.52 2.55
Sulfosulfuron content percent by mass 0.475 to 0.55 0.52 0.51 0.52
Pendimethalin content percent by mass 14.25 to 15.75 15.50 15.30 15.49
Pyroxasulfone suspensibility percent min. 80 97.50 96.50 97.30
Sulfosulfuron suspensibility precent min. 80 98.50 97.50 98.30
Pendimethalin suspensibility precent min. 80 98.50 97.70 98.40
pH range (1% aq. Suspension) 7.0 to 10.0 7.25 7.35 7.25
Pourability 95% min. 98.00 97.10 97.20
Specific gravity 1.00-1.10 1.05 1.05 1.05
Viscosity at spindle no. 62, 20 rpm 350-800 cps 650 660 675
Particle size (micron) D50<3, D90<10 2.2,8.6 2.4,8.8 2.5,8.9
Persistent foam ml (after 1 minute) max. 60 nil 3 Nil
Room temperature storage
Parameters Specification (in house) 1 month 6 months 12 months
Pyroxasulfone content percent by mass 2.375 to 2.75 2.55 2.55 2.55
Sulfosulfuron content percent by mass 0.475 to 0.55 0.52 0.52 0.52
Pendimethalin content percent by mass 14.25 to 15.75 15.50 15.50 15.49
Pyroxasulfone suspensibility percent min. 80 97.50 96.50 97.30
Sulfosulfuron suspensibility precent min. 80 98.50 97.50 98.30
Pendimethalin suspensibility precent min. 80 98.50 97.70 98.40
pH range (1% aq. Suspension) 7.0 to 10.0 7.25 7.35 7.25
Pourability 95% min. 98.00 97.50 97.00
Specific gravity 1.00-1.10 1.05 1.05 1.05
Viscosity at spindle no. 62, 20 rpm 350-800 cps 650 660 675
Particle size (micron) D50<3, D90<10 2.2,8.6 2.4,8.8 2.5,8.9
Persistent foam ml (after 1 minute) max. 60 nil 3 Nil

[00123] EXAMPLE 2 – A suspension concentrate(SC) formulation
[00124] A 100L suspension concentrate formulation was prepared with components as per Table 3. 2% gum solution was prepared by charging 2 kg xanthan gum and 2 kg 1,2-benzisothiazoline-3-one into 96 kg water and homogenized 12-18 hours prior to use. Charged 54.4 kg of DM water, 5 kg of 1,2-propylene glycol and 5 kg of urea into designated vessel and mixed thoroughly. Added 2 kg of attapulgite clay, 3.5 kg of copolymer butanol EO/PO, 1.5 kg of acrylic graft copolymer, 2 kg of Tristyrylphenol with 16 moles EO and 0.15 kg of polydimethylsiloxane into the vessel having water and homogenized the contents for 45 – 60 minutes using high shear homogenizer. Then added 10 kg of Pyroxasulfone technical, 4 kg of Halosulfuron methyl technical and 2 kg of Topramezone technical to this premix slowly and homogenized to get uniform slurry ready for grinding. Before grinding half the quantity of antifoam was added and then material was subjected to grinding in Dyno mill till desired particle size was achieved. Added remaining 0.15 kg of Polydimethyl siloxane antifoam after grinding process completed and before sampling for in process analysis. Finally added 10 kg of 2% gum solution to this formulation to give the final SC formulation.
Table 3: A suspension concentrate (SC) formulation
Ingredients Percent (w/w)
Pyroxasulfone a.i. 10.00
Halosulfuron methyl a.i. 4.00
Topramezone a.i. 2.00
Urea 5.00 Humectant
Copolymer butanol EO/PO 3.50 Wetting agent
Acrylic graft copolymer 1.50 Dispersing agent 1
Tristryphenole with 16 moles EO 2.00 Dispersing agent 2
Attapulgite clay 2.00 Suspending agent
Polydimethyl siloxane 0.30 Antifoaming agent
1,2- benzisothiazoline-3-one 0.15 Preservative
1,2-Propylene glycol 5.00 Antifreezing agent
Xanthan gum 0.15 Thickener
Water 64.40 Diluent Water
Total 100.00

[00125] Storage stability of the formulation under lab and normal room conditions was also studied and the results are provided in the Table 4 below.
Table 4: Storage stability of suspension concentrate formulation
Laboratory storage for 14 days
Parameters Specification (in house) Initial At 54±2 0C At 0±2 0C
Pyroxasulfone content percent by mass 9.50 to 10.50 10.50 10.35 10.50
Halosulfuron methyl content percent by mass 3.80 to 4.40 4.25 4.15 4.25
Topramezone content percent by mass 1.90 to 2.20 2.25 2.20 2.25
Pyroxasulfone suspensibility percent mini. 80 98.55 95.65 96.25
Halosulfuron methyl suspensibility percent mini. 80 98.14 94.56 97.91
Topramezone suspensibility percent mini. 80 97.13 94.25 96.10
pH range (1% aq. Suspension) 5.0 to7.5 6.50 6.55 6.50
Pourability 95 % min 98.70 97.70 97.60
Specific gravity 1.05 – 1.15 1.09 1.09 1.09
Viscosity at spindle no.62, 20 rpm 350 -800 cps 510 520 530
Particle size (micron) D50 <3, D90 <10 2.2, 7.9 2.6, 8.5 2.7, 8.5
Persistent foam ml (after 1 minute) max. 60 nil nil nil
Room temperature storage
Parameters Specification (in house) 1 month 6 months 12 months
Pyroxasulfone content percent by mass 9.50 to 10.50 10.50 10.50 10.50
Halosulfuron methyl content percent by mass 3.80 to 4.40 4.25 4.25 4.25
Topramezone content percent by mass 1.90 to 2.20 2.25 2.25 2.25
Pyroxasulfone suspensibility percent mini. 80 97.85 97.61 97.19
Halosulfuron methyl suspensibility percent mini. 80 97.62 97.14 96.33
Topramezone suspensibility percent mini. 80 96.15 96.56 95.65
pH range (1% aq. Suspension) 5.0 to7.5 6.50 6.55 6.50
Pourability 95 % min 98.70 98.60 98.30
Specific gravity 1.05 – 1.15 1.09 1.09 1.09
Viscosity at spindle no.62, 20 rpm 350 -800 cps 510 510 515
Particle size (micron) D50 <3, D90 <10 2.2, 8 2.2, 8.1 2.3, 8.2
Persistent foam ml (after 1 minute) max. 60 nil nil Nil

[00126] EXAMPLE 3 – A wettable granule or water dispersible granule (WG) formulation
[00127] A 100kg wettable granule formulation was prepared with components as per Table 5. Charged 5 kg corn starch, 5 kg sodium sulfate, 2.09 kg China clay, 0.5 kg silicone antifoam, 2 kg sodium alkyl napthalene sulfonate blend, 3kg Polyacrylate polymer sodium salt, 7 kg alkylated napthalene sulfonate, sodium salt into a ribbon or premix blender and homogenized for 30 minutes. Then charged 66.67 kg Atrazine, 8 kg Pyroxasulfone and 0.24 kg Metsulfuron methyl and again homogenized for 30 minutes and then this pre-blended material was ground through jet mill/ air classifier mills. Finely ground material was blended in post blender (for approx 1.5 hr) till it became homogeneous. Finely ground powder was mixed with 5 kg of water having 0.5 kg silicone antifoam to form extrudable dough. Dough was passed through extruder to get granules of required size. Wet granules were passed through fluidized bed drier to remove 5 kg extra water added and further graded using vibrating screens.
Table 5: A wettable granule (WG) formulation
Ingredients Percent (w/w)
Pyroxasulfone a.i. 8.00
Metsulfuron methyl a.i. 0.24
Atrazine a.i. 66.67
Alkylated naphthalene sulfonate, sodium salt 7.00
Polyacrylate polymer sodium salt 3.00
Sodium alkyl naphthalene sulfonate blend 2.00
Silicone antifoam 1.00
Sodium sulfate anhydrous 5.00
Corn starch 5.00
China Clay 2.09
Total 100.00

[00128] Storage stability of the wettable granule formulation was also studied and the results are provided in Table 6 below.
Table 6: Storage stability of wettable granule formulation
Laboratory storage for 14 days
Parameters specification (in house) Initial At 54±2 0C At 0±2 0C
Pyroxasulfone content percent by mass 7.60 to 8.80 8.25 8.2 8.25
Metsulfuron methyl content percent by mass 0.23 to 0.26 0.26 0.25 0.26
Atrazine content percent by mass 63.34 to 70.00 67.00 66.85 67.00
Pyroxasulfone suspensibility percent min. 70 97.15 95.02 97.52
Metsulfuron methyl suspensibility percent min. 70 95.36 91.15 94.56
Atrazine suspensibility percent min. 70 95.75 93.11 94.25
pH range (1% aq. Suspension) 5.5 to 7.5 7.03 7.01 7.03
wettability sec. max. 60 8 9 9
wet sieve (45 micron) percent by mass min. 98.5 99.5 99.2 99.3
bulk density (g/ml) 0.45 to 0.75 0.47 0.46 0.47
moisture content percent by mass max. max. 2% 1.1 0.8 1
Room temperature storage stability up to 12 months
Parameters Specification (in house) 1 month 6 months 12 months
Pyroxasulfone content percent by mass 7.60 to 8.80 8.25 8.25 8.25
Metsulfuron methyl content percent by mass 0.23 to 0.26 0.26 0.26 0.26
Atrazine content percent by mass 63.34 to 70.00 67.00 67.00 67.00
Pyroxasulfone suspensibility percent min. 70 96.98 96.85 96.14
Metsulfuron methyl suspensibility percent min. 70 95.12 94.46 94.16
Atrazine suspensibility percent min. 70 95.24 95.02 94.58
pH range (1% aq. Suspension) 5.5 to 7.5 7.03 7.03 7.02
wettability sec. max. 60 8 8 9
wet sieve (45 micron) percent by mass min. 98.5 99.30 99.30 99.20
bulk density (g/ml) 0.45 to 0.75 0.47 0.46 0.46
moisture content percent by mass max. max. 2% 1.10 1.00 0.90

[00129] EXAMPLE 4 – A wettable powder (WP) formulation
[00130] A 100kg wettable powder formulation was prepared with components as per Table 7. Charged 30kg silica, 10kg sodium sulfate, 14.25kg China clay, 1kg silicone antifoam, 2kg sodium alkyl napthalene sulfonate blend, 3kg polyacrylate polymer sodium salt,7kg alkylated napthalene sulfonate, sodium salt, 10kg Pyroxasulfone and 0.75kg Chlorimuron ethyl into a ribbon or premix blender and homogenized for 30 minutes. 20 kg melted Clomazone at 40 degrees and added 2 kg of copolymer butanol EO/PO into a vessel and blended for 10 minutes. This was then sprayed on preblend powder ready for milling and homogenized for 30 more minutes. Pre-blended material was then ground through Jet mill/ air classifier mills. Finely ground material was blended in post blender till it became homogeneous (for approx 1.5 hr).
Table 7: A wettable powder (WP) formulation
Ingredients Percent (w/w)
Pyroxasulfone a.i. 10.00
Chlorimuron ethyl a.i. 0.75
Clomazone a.i. 20.00
Alkylated naphthalene sulfonate, sodium salt 7.00
Polyacrylate polymer sodium salt 3.00
Copolymer butanol EO/PO 2.00
Sodium alkyl naphthalene sulfonate blend 2.00
Silicone antifoam 1.00
Sodium sulfate anhydrous 10.00
Silica 30.00
China Clay 14.25
Total 100.00

[00131] Storage stability of the wettable powder formulation prepared above was also studied and the results are provided in the Table 8 below.
Table 8: Storage stability of wettable powder formulation
Laboratory storage stability for 14 days
Parameters specification (in house) Initial At 54±2 0C At 0±2 0C
Pyroxasulfone content percent by mass 9.50 to 10.50 10.35 10.25 10.35
Chlorimuron ethyl content percent by mass 0.71 to 0.83 0.80 0.79 0.8
Clomazone content percent by mass 19.00 to 21.00 20.50 20.4 20.5
Pyroxasulfone suspensibility percent min. 70 97.15 95.02 97.52
Chlorimuron ethyl suspensibility percent min. 70 95.36 91.15 94.56
Clomazone suspensibility percent min. 70 95.75 93.11 94.25
pH range (1% aq. Suspension) 5.5 to 8.5 7.03 7.01 7.03
wettability sec. max. 60 8 9 9
wet sieve (45 micron) percent by mass min. 98.5 99.5 99.2 99.3
bulk density (g/ml) 0.45 to 0.75 0.47 0.46 0.47
moisture content percent by mass max. max. 2% 1.1 0.8 1
Room temperature storage stability up to 12 months
Parameters Specification (in house) 1 month 6 months 12 months
Pyroxasulfone content percent by mass 9.50 to 10.50 10.35 10.35 10.35
Chlorimuron ethyl content percent by mass 0.71 to 0.83 0.80 0.80 0.80
Clomazone content percent by mass 19.00 to 21.00 20.50 20.50 20.50
Pyroxasulfone suspensibility percent min. 70 96.98 96.85 96.14
Chlorimuron ethyl suspensibility percent min. 70 95.12 94.46 94.16
Clomazone suspensibility percent min. 70 95.24 95.02 94.58
pH range (1% aq. Suspension) 5.5 to 8.5 7.03 7.01 7.03
wettability sec. max. 60 8 8 9
wet sieve (45 micron) percent by mass min. 98.5 99.30 99.30 99.20
bulk density (g/ml) 0.45 to 0.75 0.47 0.46 0.46
moisture content percent by mass max. max. 2% 1.10 1.00 0.90

[00132] EXAMPLE 5: BIOLOGICAL STUDIES
[00133] Field experiments were carried out to study the bioefficacy, phyto-toxicity and synergism of the formulations as per the present disclosure.
[00134] Bioefficacy (Weed control %): Weed count was recorded at 30 and 45 DAA (Days after Application) by using (50 cm x 50 cm) quadrant treatment wise at 4 places randomly selected covering entire treatment. The weed control (%) was calculated by using the formula:

The weed control (as observed weed control %) data is used in Colby’s formula to calculate the expected weed control (%) and synergism.
[00135] A synergistic effect exists wherever the action of a combination of active ingredient is greater than the sum of the action of each of the components alone. Therefore, a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticidal activity than the sum of the pesticidal activities of the individual components.


[00136] Phyto-toxicity: The observations on crop safety i.e. phyto-toxicity or adverse effect of treatments were recorded for symptoms visible. All the visual phyto-toxicity symptoms like plant yellowing, leaf scorching, bleaching, necrosis, stunting, crinkling, epinasty, and hyponasty were recorded on the basis of entire plot in comparison with untreated control (UTC) plot. Each individual visual symptom was recorded on the basis of severity of injury i.e. from 0 to 100%. The observations on productive tillers were recorded from 4 spots, each spot of 1m x 1m size and represented as number of productive tillers per 1 sq. m. area. Plant heights (in cm) were also recorded.
[00137] 5.1 Bioefficacy against mixed weedflora in wheat, Triticum aestivum
Experiment: Crop: Wheat
No. of Treatments: As per treatment details;
Plot size: 25 sq.m.;
Application Time: 2 DAS (Days after sowing);
Spray Volume: 500L water per hectare;
Application Equipment: Manually operated knapsack sprayer fitted with flat fat nozzle;
Agronomic practices: All the required agronomic practices were followed except herbicidal application.
Observations: Twenty formulations were prepared for the experiment of which T1-T4 were as per the present disclosure.

Table 9: Treatment details for weed control and crop safety studies
Treatment number Treatments Application Rate (gai/h)
T1 Pyroxasulfone 2.5%+Sulfosulfuron 0.5% + Pendimethalin 15% SE (EXAMPLE 1) 100+20+600
T2 Pyroxasulfone 2.5%+Sulfosulfuron 0.5%+S-metolachlor 15% SE 100+20+600
T3 Pyroxasulfone 8%+Sulfosulfuron 1.6%+Metribuzin 5% SE 100+20+62.5
T4 Pyroxasulfone 8%+Sulfosulfuron 1.6%+Flufenacet 8% SE 100+20+100
T5 Pyroxasulfone 85% WG+Sulfosulfuron 75% WG 100+20
T6 Pyroxasulfone 85% WG+Pendimethalin 30% EC 100+600
T7 Pyroxasulfone 85% WG+S-metolachlor 30% EC 100+600
T8 Pyroxasulfone 85% WG+Metribuzin 70% WP 100+62.5
T9 Pyroxasulfone 85% WG+Flufenacet 60% DF 100+100
T10 Sulfosulfuron 75% WG+Pendimethalin 30% EC 20+600
T11 Sulfosulfuron 75% WG+S-metolachlor 30% EC 20+600
T12 Sulfosulfuron 75% WG+Metribuzin 70% WP 20+62.5
T13 Sulfosulfuron 75% WG+Flufenacet 60% DF 20+100
T14 Pyroxasulfone 85% WG 100
T15 Sulfosulfuron 75% WG 20
T16 Pendimethalin 30% EC 600
T17 S-metolachlor 30% EC 600
T18 Metribuzin 70% WP 62.5
T19 Flufenacet 60% DF 100
T20 UTC (Untrated Check) 0
T1, T2, T3 and T4 were ready-to-mix compositions as per the present disclosure.T5 to T13 were conventional tank mix compositions. (SE- suspo-emulsion, WG- Wettable Granule, WP-Wettable powder, EC-emulsifiable concentrate, DF-dry flowable and Gai/h is gram active per hectare.)
[00138] The bioefficacy of these twenty treatments were studied against a mixed set of weedflora in wheat crop and Table 10 below provides the results. Weed flora observed in trial plots were Grasses-Phalaris minor, Avena fatua, broad leaf weeds-Chenopodium album, Melilotus spp., Medicago spp., and Rumex spp.

Table 10: Bioefficacy against mixed weedflora in wheat crop
Treatment number % Weed control Synergism (Y/N) Average number of productive tillers/sq.mt. Plant height (cm)
30 DAA 45 DAA
OV EV Colby's ratio OV EV Colby's ratio
T1 98.6 92.29 1.07 94.8 85.93 1.10 Y 300.6 90.2
T2 98.2 91.59 1.07 92.6 84.85 1.09 Y 301.2 90.8
T3 99.0 92.33 1.07 93.6 85.87 1.09 Y 303.4 91.2
T4 98.4 91.43 1.08 95.8 83.60 1.15 Y 302.2 91.4
T5 79.8 80.34 0.99 67.4 71.63 0.94 N 291.2 86.2
T6 83.8 84.40 0.99 72.4 75.40 0.96 N 294.6 85.4
T7 82.2 82.97 0.99 70.8 73.51 0.96 N 295.2 85.2
T8 84.0 84.48 0.99 69.8 75.30 0.93 N 296.6 86.0
T9 82.2 82.65 0.99 67.6 71.33 0.95 N 296.8 85.8
T10 79.8 80.64 0.99 65.2 71.63 0.91 N 288.4 86.2
T11 78.4 78.86 0.99 64.4 69.46 0.93 N 289.2 86.8
T12 80.0 80.73 0.99 67.2 71.51 0.94 N 287.6 87.2
T13 78.0 78.46 0.99 62.4 66.94 0.93 N 285.6 87.4
T14 60.2 50.4 278.4 84.2
T15 50.6 42.8 276.0 83.8
T16 60.8 50.4 277.8 84.4
T17 57.2 46.6 275.2 83.6
T18 61.0 50.2 277.4 84.0
T19 56.4 42.2 278.2 83.2
T20 0.0 0.0 268.4 79.6
DAA - days after application. OV- observed value, EV- expected value.

[00139] The compositions of the present disclosure comprising pyroxasufone + sulfosulfuron + herbicide (i.e., T1 to T4) provided excellent synergistic control of all weeds in wheat crop and also produced higher number of productive tillers compared to all conventional tank mix compositions (T5 to T13). None of the treatments show any kind of phyto-toxicity symptoms in wheat crop.
[00140] 5.2: Weed control and crop safety in Wheat crop
Experiment: Crops: Wheat
No. of Treatments: As per treatment details
Plot size: 30 sq.m.
Application Time: 5 DAS (Days after sowing)
Spray Volume: 500 liter water per hectare
Application Equipment: Manually operated knapsack sprayer fitted with flat fat nozzle
Agronomic practices: All the required agronomic practices were followed except herbicidal application.
Observations: Same parameters were determined as given in part 5.1.
[00141] Twenty formulations were prepared for the experiment of which T1-T4 were as per the present disclosure, as disclosed in Table 11.
Table 11: Treatment details for weed control and crop safety study
Treatment number Treatments Application Rate (gai/h)
T1 Pyroxasulfone 2.5%+Metsulfuron methyl 0.1%+Pendimethalin 15% SE 100+4+600
T2 Pyroxasulfone 2.5%+Metsulfuron methyl 0.1%+S-metolachlor 15% SE 100+4+600
T3 Pyroxasulfone 8%+Metsulfuron methyl 0.32%+Metribuzin 5% SE 100+4+62.5
T4 Pyroxasulfone 8%+Metsulfuron methyl 0.32%+Flufenacet 8% SE 100+4+100
T5 Pyroxasulfone 85% WG+Metsulfuron methyl 20% WG 100+4
T6 Pyroxasulfone 85% WG+Pendimethalin 30% EC 100+600
T7 Pyroxasulfone 85% WG+S-metolachlor 30% EC 100+600
T8 Pyroxasulfone 85% WG+Metribuzin 70% WP 100+62.5
T9 Pyroxasulfone 85% WG+Flufenacet 60% DF 100+100
T10 Metsulfuron methyl 20% WG+Pendimethalin 30% EC 4+600
T11 Metsulfuron methyl 20% WG+S-metolachlor 30% EC 4+600
T12 Metsulfuron methyl 20% WG+Metribuzin 70% WP 4+62.5
T13 Metsulfuron methyl 20% WG+Flufenacet 60% DF 4+100
T14 Pyroxasulfone 85% WG 100
T15 Metsulfuron methyl 20% WG 4
T16 Pendimethalin 30% EC 600
T17 S-metolachlor 30% EC 600
T18 Metribuzin 70% WP 62.5
T19 Flufenacet 60% DF 100
T20 UTC (Untrated Check) 0
T1, T2, T3 and T4 were ready-to-mix formulations as per the present disclosure and T5 to T13 were conventional tank mix combinations.
[00142] The bioefficacy of these twenty treatments were studied against a mixed set of weedflora in wheat crop and Table 12 below provides the results. Weed flora observed in trial plots were Grasses-Avena fatua, broad leaf weeds-Solanum nigrum, Chenopodium murale, Anagallis arvensis, and Fumaria parviflora.
Table 12: Bioefficacy against mixed weedflora in wheat crop
Treatment number % Weed control Synergism (Y/N) Average number of productive tillers/sq.mt. Plant height (cm)
30 DAA 45 DAA
OV EV Colby's ratio OV EV Colby's ratio
T1 94.6 86.40 1.09 88.6 77.74 1.14 Y 310.4 91.4
T2 96.2 86.02 1.12 85.2 77.51 1.10 Y 311.5 92.2
T3 97.2 88.48 1.10 89.2 81.53 1.09 Y 312.2 91.6
T4 96.4 87.00 1.11 86.4 79.75 1.08 Y 318.6 92.4
T5 72.00 72.70 0.99 60.2 62.77 0.96 N 294.1 87.4
T6 77.6 78.49 0.99 64.4 67.83 0.95 N 299.4 88.6
T7 77.2 77.88 0.99 63.8 67.50 0.95 N 298.4 89.2
T8 80.6 81.77 0.99 70.8 73.32 0.97 N 297.7 88.7
T9 77.8 79.44 0.98 67.4 70.73 0.95 N 298.3 89.4
T10 67.4 68.53 0.98 54.2 58.62 0.92 N 290.2 87.6
T11 66.2 67.64 0.98 53.6 58.20 0.92 N 291.5 88.3
T12 72.8 73.33 0.99 61.2 65.68 0.93 N 292.7 89.5
T13 68.8 69.92 0.98 57.4 62.36 0.92 N 289.8 89.2
T14 56.8 46.2 285.3 86.2
T15 36.8 30.8 280.4 87.3
T16 50.2 40.2 286.2 87.6
T17 48.8 39.6 284.6 87.8
T18 57.8 50.4 287.3 87.2
T19 52.4 45.6 286.2 87.4
T20 0.0 0.0 272.7 81.4

[00143] The formulations of the present disclosure comprising of Pyroxasufone + metsulfuron methyl + herbicide (T1 to T4) provided excellent synergistic control of all weeds in wheat crop as compared to all the conventional tank mix combinations (T5 to T13). The formulations T1 to T4 were also observed to be safer for crop, as can be seen from the plant height and number of productive tillers. The productive tillers directly contribute to the grain yield.
[00144] 5.3 Weed control and crop safety in sugarcane, Saccharum officinarum
[00145] Experiment: Crops: Sugarcane
No. of Treatments: As per treatment details
Plot size: 40 sq. mt.
Application Time: 15 DAP (Days after planting)
Spray Volume: 500L water per hectare
Application Equipment: Manually operated knapsack sprayer fitted with flat fat nozzle
Agronomic practices: All the required agronomic practices were followed except herbicidal application.
[00146] Observations: Same parameters were determined as given in part 5.1. Shoot count, was also determined which is the count of the number of shoots per 1 meter row length (mrl). Recorded such observations from 5 spots per plot and presented the data as number of shoots per mrl. 24 formulations were prepared for the experiment, of which T1-T5 were as per the present disclosure, as disclosed in Table 13.

Table 13: Treatment details for weed control and crop safety study
Treatment Number Treatments details Application Rate (gai/h)
T1 Pyroxasulfone 30%+Metsulfuron methyl 1%+Isoxaflutole 30% WG 120+4+120
T2 Pyroxasulfone 4%+Metsulfuron methyl 0.133%+Clomazone 20% ZC 120+4+600
T3 Pyroxasulfone 12%+Metsulfuron methyl 0.4%+Sulfentrazone 50% WG 120+4+500
T4 Pyroxasulfone 8%+Metsulfuron methyl 0.24%+Ametryn 66.67% WG 120+4+1000
T5 Pyroxasulfone 8%+Metsulfuron methyl 0.24%+Atrazine 66.67% WG (EXAMPLE 3) 120+4+1000
T6 Pyroxasulfone 85% WG+Metsulfuron methyl 20% WG 120+4
T7 Pyroxasulfone 85% WG+Isoxaflutole 75% WG 120+120
T8 Pyroxasulfone 85% WG+Clomazone 50% EC 120+600
T9 Pyroxasulfone 85% WG+Sulfentrazone 40% SC 120+500
T10 Pyroxasulfone 85% WG+Ametryn 80% WG 120+1000
T11 Pyroxasulfone 85% WG+Atrazine 50% WP 120+1000
T12 Metsulfuron methyl 20% WG+Isoxaflutole 75% WG 4+120
T13 Metsulfuron methyl 20% WG+Clomazone 50% EC 4+600
T14 Metsulfuron methyl 20% WG+Sulfentrazone 40% SC 4+500
T15 Metsulfuron methyl 20% WG+Ametryn 80% WG 4+1000
T16 Metsulfuron methyl 20% WG+Atrazine 50% WP 4+1000
T17 Pyroxasulfone 85% WG 120
T18 Metsulfuron methyl 20% WG 4
T19 Isoxaflutole 75% WG 120
T20 Clomazone 50% EC 600
T21 Sulfentrazone 40% SC 500
T22 Ametryn 80% WG 1000
T23 Atrazine 50% WP 1000
T24 UTC (Untrated Check) 0
T1, T2, T3, T4 and T5 were ready-to-mix compositions as per the present disclosure.T6 to T16 were conventional tank mix combinations. NIS (Non ionic surfactant) was added in all treatments @ 2 ml/liter of water.
[00147] The bioefficacy of these twenty four treatments were studied against a mixed set of weedflora in sugarcane crop and Table 14 below provides the results. Weed flora observed in trial plots were Grassy weeds (Echinochloa colonum, Eluesine indica), Broad leaf weeds (Trianthemamonogyna, Digera arvensis, Amaranthus viridis), and Sedges (Cyperus rotundus).
Table 14: Synergistic weed control in sugarcane
Treatment Number % Weed control Synergism (Y/N) Average number of shoots/mrl at 60 DAA
30 DAA 60 DAA
OV EV Colby's ratio OV EV Colby's ratio
T1 98.4 81.76 1.20 89.4 77.22 1.16 Y 70.6
T2 99.4 82.19 1.21 90.2 77.50 1.16 Y 71.8
T3 97.4 82.75 1.18 85.8 78.42 1.09 Y 72.7
T4 96.8 81.82 1.18 85.2 77.85 1.09 Y 70.8
T5 98.2 83.81 1.17 88.6 79.69 1.11 Y 74.2
T6 68.2 68.98 0.99 63.8 64.73 0.99 N 67.8
T7 69.0 69.19 1.00 60.2 63.95 0.94 N 65.2
T8 68.8 69.92 0.98 58.6 64.40 0.91 N 66.8
T9 70.2 70.87 0.99 59.2 65.85 0.90 N 65.9
T10 68.8 69.29 0.99 60.2 64.96 0.93 N 64.7
T11 71.8 72.65 0.99 62.4 67.86 0.92 N 63.6
T12 64.6 65.19 0.99 53.4 59.17 0.90 N 63.6
T13 65.2 66.02 0.99 53.6 59.68 0.90 N 62.6
T14 66.2 67.08 0.99 55.6 61.32 0.91 N 64.5
T15 64.6 65.31 0.99 54.4 60.31 0.90 N 59.8
T16 68.4 69.10 0.99 57.2 63.60 0.90 N 58.7
T17 47.6 44.2 57.3
T18 40.8 36.8 56.9
T19 41.2 35.4 53.7
T20 42.6 36.2 54.1
T21 44.4 38.8 52.7
T22 41.4 37.2 48.7
T23 47.8 42.4 49.1
T24 0.0 0.0 34.6

[00148] The formulations of the present disclosure comprising Pyroxasulfone + Metsulfuron methyl + herbicide (T1 to T5) provided synergistic control of weeds with residual control and did not show any kind of phyto-toxicity to the sugarcane crop. The treatment groups T1 to T5 also produced higher number of shoots per mrl which directly contributes to the sugarcane yield.
[00149] 5.4 Crop safety and weed control in sugarcane, Saccharum officinarum
Experiment: Crops: Sugarcane
No. of Treatments: As per treatment details
Plot size: 50 sq. m.
Application Time: 4 to 6 leaf stage of weed and crop as 40 DAP (Days after planting)
Spray Volume: 500 L water per hectare
Application Equipment: Manually operated knapsack sprayer fitted with flat fat nozzle
Agronomic practices: All the required agronomic practices were followed except herbicidal application.
[00150] Observations: The parameters determined were same as in previous parts. 24 formulations were prepared for the experiment, of which T1-T5 were as per the present disclosure, as disclosed in Table 15.

Table 15: Treatment details for weed control and crop safety study
Treatment Number Treatments details Application Rate (gai/h)
T1 Pyroxasulfone 10%+Halosulfuron methyl 4%+Mesotrione 10% SC 100+40+100
T2 Pyroxasulfone 10%+Halosulfuron methyl 4%+Tembotrione 5% SC 100+40+50
T3 Pyroxasulfone 10%+Halosulfuron methyl 4%+Topramezone 2% SC (Example 2) 100+40+20
T4 Pyroxasulfone 10%+Halosulfuron methyl 4%+Flumioxazine 10% SC 100+40+100
T5 Pyroxasulfone 16.67%+Halosulfuron methyl 6.67%+Tolpyralate 5% SC 100+40+30
T6 Pyroxasulfone 85% WG+Halosulfuron methyl 75% WG 100+40
T7 Pyroxasulfone 85% WG+Mesotrione 42% SC 100+100
T8 Pyroxasulfone 85% WG+Tembotrione 34.4% SC 100+50
T9 Pyroxasulfone 85% WG+Topramezone 33.6% SC 100+20
T10 Pyroxasulfone 85% WG+Flumioxazine 50% SC 100+100
T11 Pyroxasulfone 85% WG+Tolpyralate 40% SC 100+30
T12 Halosulfuron methyl 75% WG+Mesotrione 42% SC 40+100
T13 Halosulfuron methyl 75% WG+Tembotrione 34.4% SC 40+50
T14 Halosulfuron methyl 75% WG+Topramezone 33.6% SC 40+20
T15 Halosulfuron methyl 75% WG+Flumioxazine 50% SC 40+100
T16 Halosulfuron methyl 75% WG+Tolpyralate 40% SC 40+30
T17 Pyroxasulfone 85% WG 100
T18 Halosulfuron methyl 75% WG 40
T19 Mesotrione 42% SC 100
T20 Tembotrione 34.4% SC 50
T21 Topramezone 33.6% SC 20
T22 Flumioxazine 50% SC 100
T23 Tolpyralate 40% SC(35.7% w/w) 30
T24 UTC (Untrated Check) 0
T1, T2, T3, T4 and T5 were ready-to-mix formulations as per the present disclosure. T6 to T16 were conventional tank mix combinations. NIS (Non ionic surfactant) was added in all treatments @ 2.5 ml/liter of water.
[00151] The bioefficacy of these twenty four treatments were studied against a mixed set of weedflora in sugarcane crop and Table 16 below provides the results. Weed flora of trial plot- Grassy weeds (Dactyloctenium aegyptium, Brachiaria mutica, Panicum spp.), Broad leaf weeds (Trianthema mongyna, Parthenium hysterophorus), and Sedges (Cyprus rotundus).
Table 16: Synergistic weed control
Treatment number % Weed control Synergism (Y/N) Average number of shoots/mrl at 75 DAP
30 DAA 60 DAA
OV EV Colby's ratio OV EV Colby's ratio
T1 98.2 91.25 1.08 92.6 85.15 1.09 Y 76.4
T2 99.0 91.07 1.09 93.2 84.07 1.11 Y 78.6
T3 97.8 91.29 1.07 91.2 85.09 1.07 Y 75.2
T4 96.4 89.75 1.07 90.2 82.57 1.09 Y 75.6
T5 97.4 90.81 1.07 91.0 84.01 1.08 Y 76.8
T6 77.2 78.01 0.99 67.2 70.06 0.96 N 68.6
T7 81.6 82.57 0.99 70.6 74.31 0.95 N 67.4
T8 81.4 82.22 0.99 67.4 72.44 0.93 N 66.8
T9 80.8 82.66 0.98 70.6 74.20 0.95 N 65.2
T10 78.2 79.59 0.98 65.2 69.85 0.93 N 67.8
T11 80.6 81.69 0.99 68.4 72.34 0.95 N 68.4
T12 78.2 80.02 0.98 68.2 71.33 0.96 N 69.2
T13 77.4 79.62 0.97 66.4 69.25 0.96 N 68.8
T14 78.6 80.12 0.98 68.4 71.22 0.96 N 69.0
T15 75.0 76.61 0.98 63.8 66.36 0.96 N 68.4
T16 78.2 79.02 0.99 65.0 69.13 0.94 N 69.4
T17 56.2 48.2 62.0
T18 49.8 42.2 60.8
T19 60.2 50.4 63.4
T20 59.4 46.8 62.8
T21 60.4 50.2 62.6
T22 53.4 41.8 61.2
T23 58.2 46.6 63.4
T24 0.0 0.0 53.6

[00152] The formulations of the present disclosure comprising Pyroxasulfone + Halosulfuron methyl + herbicide (i.e., T1 to T5) provide synergistic control of weeds with residual control and do not show any kind of phyto-toxicity to the sugarcane crop. The treatments T1 to T5 also produce higher number of shoots per mrl which directly contributes to the cane yield.
[00153] 5.5 Synergistic weed control in sugarcane
Experiment: Crops: Sugarcane
No. of Treatments: As per treatment details
Plot size: 40 sq. m.
Application Time: 2 to 4 leaf stage of weed and crop as 22 DAP (Days after planting)
Spray Volume: 500 L water per hectare
Application Equipment: Manually operated knapsack sprayer fitted with flat fat nozzle
Agronomic practices: All the required agronomic practices were followed except herbicidal application.
[00154] Observations: The parameters determined were same as in previous parts. 24 formulations were prepared for the experiment, of which T1-T5 were as per the present disclosure, as disclosed in Table 17.
Table 17: Treatment details for weed control and crop safety study
Treatment Number Treatments details Application Rate (gai/h)
T1 Pyroxasulfone 24%+Trifloxysulfuron sodium 8%+Mesotrione 20% WG 120+40+100
T2 Pyroxasulfone 24%+Trifloxysulfuron sodium 8%+Tembotrione 10% WG 120+40+50
T3 Pyroxasulfone 24%+Trifloxysulfuron sodium 8%+Topramezone 4% WG 120+40+20
T4 Pyroxasulfone 24%+Trifloxysulfuron sodium 8%+Flumioxazine 20% WG 120+40+100
T5 Pyroxasulfone 40%+Trifloxysulfuron sodium 13.33%+Diclosulam 8% WG 120+40+24
T6 Pyroxasulfone 85% WG+Trifloxysulfuron sodium 75% WG 120+40
T7 Pyroxasulfone 85% WG+Mesotrione 42% SC 120+100
T8 Pyroxasulfone 85% WG+Tembotrione 34.4% SC 120+50
T9 Pyroxasulfone 85% WG+Topramezone 33.6% SC 120+20
T10 Pyroxasulfone 85% WG+Flumioxazine 50% SC 120+100
T11 Pyroxasulfone 85% WG+Diclosulam 84% WDG 120+24
T12 Trifloxysulfuron sodium 75% WG+Mesotrione 42% SC 40+100
T13 Trifloxysulfuron sodium 75% WG+Tembotrione 34.4% SC 40+50
T14 Trifloxysulfuron sodium 75% WG+Topramezone 33.6% SC 40+20
T15 Trifloxysulfuron sodium 75% WG+Flumioxazine 50% SC 40+100
T16 Trifloxysulfuron sodium 75% WG+Diclosulam 84% WDG 40+24
T17 Pyroxasulfone 85% WG 120
T18 Trifloxysulfuron sodium 75% WG 40
T19 Mesotrione 42% SC 100
T20 Tembotrione 34.4% SC 50
T21 Topramezone 33.6% SC 20
T22 Flumioxazine 50% SC 100
T23 Diclosulam 84% WDG 24
T24 UTC (Untreated Check) 0
T1, T2, T3, T4 and T5 were ready-to-mix compositions as per the present disclosure.T6 to T16 were conventional tank mix combinations. NIS (Non ionic surfactant) were added in all treatments @ 2.5 ml/liter of water
[00155] The bioefficacy of these twenty four treatments were studied against a mixed set of weedflora in sugarcane crop and Table 18 below provides the results. Weed flora of trial plot- Grassy weeds (Echinochloa colonum, Dactyloctenium aegyptium, Panicum spp.), Broad leaf weeds (Trianthema mongyna, Physalis minima), and Sedges (Cyprus rotundus).
Table 18: Synergistic weed control
Treatment number % Weed control Synergism (Y/N) Average number of shoots/mrl at 75 DAP
30 DAA 60 DAA
OV EV Colby's ratio OV EV Colby's ratio
T1 99.2 93.32 1.06 94.6 86.61 1.09 Y 68.4
T2 99.6 93.26 1.07 93.8 86.71 1.08 Y 69.2
T3 98.8 93.79 1.05 93.0 87.46 1.06 Y 68.4
T4 99.4 93.20 1.07 93.2 87.11 1.07 Y 69.2
T5 98.4 93.32 1.05 94.0 86.25 1.09 Y 67.8
T6 84.0 84.40 1.00 71.4 74.83 0.95 N 56.8
T7 82.4 83.05 0.99 69.8 72.44 0.96 N 57.2
T8 81.2 82.89 0.98 68.8 72.65 0.95 N 58.4
T9 82.8 84.24 0.98 70.4 74.20 0.95 N 57.4
T10 81.0 82.73 0.98 69.6 73.48 0.95 N 55.8
T11 81.6 83.05 0.98 68.2 71.72 0.95 N 56.4
T12 81.4 83.14 0.98 70.4 74.14 0.95 N 60.2
T13 80.6 82.98 0.97 69.2 74.34 0.93 N 59.8
T14 82.4 84.32 0.98 71.8 75.80 0.95 N 61.2
T15 80.4 82.82 0.97 71.2 75.12 0.95 N 60.8
T16 81.4 83.14 0.98 69.4 73.46 0.94 N 59.8
T17 60.4 48.2 47.8
T18 60.6 51.4 49.6
T19 57.2 46.8 50.4
T20 56.8 47.2 48.2
T21 60.2 50.2 49.2
T22 56.4 48.8 48.4
T23 57.2 45.4 46.8
T24 0.0 0.0 38.4

[00156] All the compositions of Pyroxasulfone + Trifloxysulfuron sodium + herbicide (T1 to T5) provided synergistic control of weeds with residual control and do not show any kind of phyto-toxicity to the sugarcane crop. The treatments T1 to T5 also produced higher number of shoots per mrl which directly contribute to the cane yield.
[00157] 5.6 Synergistic weed control in soybean, Glycine max
Experiment: Crops: Soybean
No. of Treatments: As per treatment details
Plot size: 30 sq. m.
Application Time: 1 day after sowing (as Pre-emergence)
Spray Volume: 500L water per hectare
Application Equipment: Manually operated knapsack sprayer fitted with flat fat nozzle
Agronomic practices: All the required agronomic practices were followed except herbicidal application.
[00158] Observations: The parameters determined were same as in previous parts. 16 formulations were prepared for the experiment, of which T1-T3 were as per the present disclosure, as disclosed in Table 19.
Table 19: Treatment details for weed control and crop safety study
Treatment Number Treatments details Application Rate (gai/h)
T1 Pyroxasulfone 40%+Chlorimuron ethyl 3%+Diclosulam 8% WG 100+7.5+20
T2 Pyroxasulfone 4%+Chlorimuron ethyl 0.3%+Clomazone 20% WP 100+7.5+500
T3 Pyroxasulfone 4%+Chlorimuron ethyl 0.3%+Sulfentrazone 20% WG 100+7.5+500
T4 Pyroxasulfone 85% WG+Chlorimuron ethyl 25% WP 100+7.5
T5 Pyroxasulfone 85% WG+Diclosulam 84% WDG 100+20
T6 Pyroxasulfone 85% WG+Clomazone 50% EC 100+500
T7 Pyroxasulfone 85% WG+Sulfentrazone 39.6% SC 100+500
T8 Chlorimuron ethyl 25% WP+Diclosulam 84% WDG 7.5+20
T9 Chlorimuron ethyl 25% WP+Clomazone 50% EC 7.5+500
T10 Chlorimuron ethyl 25% WP+Sulfentrazone 39.6% SC 7.5+500
T11 Pyroxasulfone 85% WG 100
T12 Chlorimuron ethyl 25% WP 7.5
T13 Diclosulam 84% WDG 20
T14 Clomazone 50% EC 500
T15 Sulfentrazone 39.6% SC 500
T16 UTC (Untrated Check) 0

[00159] The bioefficacy of these sixteen treatments were studied against a mixed set of weedflora in sugarcane crop and Table 20 below provides the results. Weed flora of trial plot- Grassy weeds (Echinochloa colonum, Eragrostic major), and Broad leaf weeds (Phyllanthus niruri, Commelina benghalensis, and Digera arvensis).
Table 20: Synergistic weed control
Treatment number % Weed control Synergism (Y/N)
15 DAA 30 DAA
OV EV Colby's ratio OV EV Colby's ratio
T1 98.2 91.25 1.08 93.2 87.03 1.07 Y
T2 99.0 91.37 1.08 94 87.40 1.08 Y
T3 97.4 91.20 1.07 92.4 87.08 1.06 Y
T4 77.2 78.85 0.98 70.2 73.41 0.96 N
T5 80.2 81.45 0.98 71.4 75.80 0.94 N
T6 79.8 81.72 0.98 72.2 76.49 0.94 N
T7 78.8 81.36 0.97 71.8 75.89 0.95 N
T8 77.4 80.46 0.96 70.4 73.84 0.95 N
T9 78.4 80.74 0.97 69.8 74.59 0.94 N
T10 79.2 80.36 0.99 69.6 73.95 0.94 N
T11 55.2 50.4
T12 52.8 46.4
T13 58.6 51.2
T14 59.2 52.6
T15 58.4 51.4
T16 0.0 0.0

[00160] All the compositions as per the present disclosure comprising Pyroxasulfone + chlorimuron ethyl + herbicide (T1, T2, T3) provided synergistic control of weeds with residual control and did not show any significant phyto-toxicity to soybean crop. Mild yellowing was observed in all the treatments which was completely recovered without affecting crop growth.
[00161] From the above results it can be clearly seen that the composition as per the present disclosure comprising Pyroxasulfone, sulfonylurea herbicide and an additional herbicide provides surprising synergistic weed control, and desirable residual control of weeds. The composition shows excellent control of tough-to-control weeds in a single shot application and does not show any significant phytotoxicity to wheat, sugarcane and soybean crop and does not have any kind of negative impact on crop growth. The composition was also shown to increase tillers counts and shoot counts which directly contribute to the crop yield.
[00162] From the foregoing, it will be appreciated that, although specific embodiments of the invention have been described herein merely for purposes of illustration, various modifications may be made without deviating from the spirit and scope of the invention and should not be construed so as to limit the scope of the invention or the appended claims in any way.

ADVANTAGES OF THE INVENTION
[00163] The present disclosure provides a synergistic herbicidal composition with broad spectrum activity and can delay the onset of herbicidal resistance.
[00164] The present disclosure provides an herbicidal composition that can be applied in a single shot reducing the burden on farmers.
[00165] The present disclosure provides an herbicidal composition which increases shoot and tiller counts which directly contribute to the crop yield.
[00166] The present disclosure provides an herbicidal composition that shows effective treatment and prevention of growth or germination of weeds.
[00167] The present disclosure provides an herbicidal composition that is non-phyto-toxic to crop plants.

,CLAIMS:1. An herbicidal composition comprising Pyroxasulfone; at least one sulfonylurea herbicide; and at least one additional herbicide.
2. The composition as claimed in claim 1, wherein the sulfonylurea herbicide is selected from the group comprising of pyrazosulfuron-ethyl, metsulfuron-methyl, halosulfuron-methyl, chlorimuron-ethyl, sulfosulfuron, trifloxysulfuron-sodium or combinations thereof.
3. The composition as claimed in claim 1, wherein the additional herbicide compound is selected from isoxaflutole, clomazone, sulfentrazone, metribuzin, ametryn, atrazine, diuron, mesotrione, tembotrione, sulcotrione, topramezone, flumioxazin, trifludimoxazin, bicyclopyrone, tolpyralate, 2,4-dichlorophenoxyacetic acid, flufenacet, penoxsulam, diclosulam, pyroxsulam, prosulfocarb, (S)-metolachlor, pendimethalin, or combinations thereof.
4. The composition as claimed in claim 1, wherein the Pyroxasulfone is present in a weight range from 0.001% to 90% with respect to the composition.
5. The composition as claimed in claim 1, wherein the sulfonylurea herbicide is present in a weight range from 0.001% to 90% with respect to the composition.
6. The composition as claimed in claim 1, wherein the additional herbicide is present in a weight range from 0.001% to 90% with respect to the composition.
7. The composition as claimed in claim 1, wherein the composition comprises 0.01% to 50% of Pyroxasulfone; 0.01% to 50% of the sulfonylurea herbicide; and 0.01% to 50% of the additional herbicide.
8. A formulation comprising Pyroxasulfone; at least one sulfonylurea herbicide; at least one additional herbicide and one or more auxiliary additives.
9. The formulation as claimed in claim 8, wherein the formulation is selected from the group comprising of capsule suspension (CS), dispersible concentrate (DC), emulsifiable concentrate (EC), emulsion, water in oil (EO), emulsion, oil in water (EW), jambo balls or bags (bags in water soluble pouch), micro-emulsion (ME), oil dispersion (OD), oil miscible flowable concentrate (oil miscible suspension) (OF), oil miscible liquid (OL), suspension concentrate (SC), suspo-emulsion (SE), soluble concentrate (SL), water dispersible granule (WG or WDG), water soluble granule (SG), water soluble powder (SP), wettable powder (WP), a mixed formulation of CS and SC (ZC), a mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), and Controlled release granules (CR).
10. The formulation as claimed in claim 8, wherein the additives are selected from dispersing agents, suspending agent, anti-freezing agent, fillers, wetting agents, wetting/spreading/penetrating agent, buffering agent, colorants, surfactants, tackifiers, pH regulators, anti-foaming agents, solvents, emulsifiers, solid carriers, disintegrating agents, stabilizer, preservatives, thickeners, humectants, and combinations thereof.
11. The formulation as claimed in claim 8, wherein the formulation is a suspension concentrate (SC) formulation comprising Pyroxasulfone; at least one sulfonylurea herbicide; at least one additional herbicide; urea; copolymer butanol EO/PO; acrylic graft copolymer; tristryphenole with 16 moles EO; attapulgite clay; polydimethyl siloxane; 1,2- benzisothiazoline-3-one; 1,2-Propylene glycol; xanthan gum; and water.
12. The formulation as claimed in claim 8, wherein the formulation is a suspo-emulsion (SE) formulation comprising Pyroxasulfone; at least one sulfonylurea herbicide; at least one additional herbicide; urea; octyl phenol ethoxylate; aromatic solvent; castor oil ethoxylate; copolymer butanol EO/PO; acrylic graft copolymer; tristryphenole with 16 moles EO; attapulgite clay; polydimethyl siloxane; 1,2- benzisothiazoline-3-one; 1,2-propylene glycol; xanthan gum; and water.
13. The formulation as claimed in claim 8, wherein the formulation is a wettable granule or water dispersible (WG) formulation comprising Pyroxasulfone; at least one sulfonylurea herbicide; at least one additional herbicide; alkylated naphthalene sulfonate, sodium salt; polyacrylate polymer sodium salt, sodium alkyl naphthalene sulfonate blend, silicone antifoam, sodium sulfate anhydrous, corn starch, water, and china clay.

14. The formulation as claimed in claim 8, wherein the formulation is a wettable powder (WP) formulation comprising Pyroxasulfone; at least one sulfonylurea herbicide; at least one additional herbicide; alkylated naphthalene sulfonate, sodium salt; polyacrylate polymer sodium salt; copolymer butanol EO/PO; sodium alkyl naphthalene sulfonate blend; silicone antifoam; sodium sulfate anhydrous; silica; water and china clay.
15. The formulation as claimed in claim 8, wherein the formulation is a suspo-emulsion (SE) formulation comprising:
(a) Pyroxasulfone in a weight percentage of 2.5%; Sulfosulfuron in a weight percentage of 0.5%; and Pendimethalin in a weight percentage of 15% of the formulation;
(b) Pyroxasulfone in a weight percentage of 2.5%; Sulfosulfuron in a weight percentage of 0.5%; and S-metolachlor in a weight percentage of 15% of the formulation;
(c) Pyroxasulfone in a weight percentage of 8%; Sulfosulfuron in a weight percentage of 1.6%; and Metribuzin in a weight percentage of 5% of the formulation;
(d) Pyroxasulfone in a weight percentage of 8%; Sulfosulfuron in a weight percentage of 1.6%; and Flufenacet in a weight percentage of 8% of the formulation;
(e) Pyroxasulfone in a weight percentage of 2.5%; Metsulfuron methyl in a weight percentage of 0.1%; and Pendimethalin in a weight percentage of 15% of the formulation;
(f) Pyroxasulfone in a weight percentage of 2.5%; Metsulfuron methyl in a weight percentage of 0.1%; and S-metolachlor in a weight percentage of 15% of the formulation;
(g) Pyroxasulfone in a weight percentage of 8%; Metsulfuron methyl in a weight percentage of 0.32%; and Metribuzin in a weight percentage of 5% of the formulation; or
(h) Pyroxasulfone in a weight percentage of 8%; Metsulfuron methyl in a weight percentage of 0.32%; and Flufenacet in a weight percentage of 8% of the formulation.
16. The formulation as claimed in claim 8, wherein the formulation is a wettable granule or water dispersible granule (WG) formulation comprising:
(a) Pyroxasulfone in a weight percentage of 30%; Metsulfuron methyl in a weight percentage of 1%; and Isoxaflutole in a weight percentage of 30% of the formulation;
(b) Pyroxasulfone in a weight percentage of 12%; Metsulfuron methyl in a weight percentage of 0.4%; and Sulfentrazone in a weight percentage of 50% of the formulation;
(c) Pyroxasulfone in a weight percentage of 8%; Metsulfuron methyl in a weight percentage of 0.24%; and Ametryn in a weight percentage of 66.67% of the formulation;
(d) Pyroxasulfone in a weight percentage of 8%; Metsulfuron methyl in a weight percentage of 0.24%; and Atrazine in a weight percentage of 66.67% of the formulation;
(e) Pyroxasulfone in a weight percentage of 40%; Trifloxysulfuron sodium in a weight percentage of 13.33%; and Diclosulam in a weight percentage of 8% of the formulation;
(f) Pyroxasulfone in a weight percentage of 24%; Trifloxysulfuron sodium in a weight percentage of 8%; and Mesotrione in a weight percentage of 20% of the formulation;
(g) Pyroxasulfone in a weight percentage of 24%; Trifloxysulfuron sodium in a weight percentage of 8%; and Tembotrione in a weight percentage of 10% of the formulation;
(h) Pyroxasulfone in a weight percentage of 24%; Trifloxysulfuron sodium in a weight percentage of 8%; and Topramezone in a weight percentage of 4% of the formulation;
(i) Pyroxasulfone in a weight percentage of 24%; Trifloxysulfuron sodium in a weight percentage of 8%; and Flumioxazin in a weight percentage of 20% of the formulation;
(j) Pyroxasulfone in a weight percentage of 40%; Chlorimuron ethyl in a weight percentage of 3%; and Diclosulam in a weight percentage of 8% of the formulation; or
(k) Pyroxasulfone in a weight percentage of 4%; Chlorimuron ethyl in a weight percentage of 0.3%; and Sulfentrazone in a weight percentage of 20% of the formulation.
17. The formulation as claimed in claim 8, wherein the formulation is a wettable powder (WP) formulation comprising Pyroxasulfone in a weight percentage of 4%; Chlorimuron ethyl in a weight percentage of 0.3%; and Clomazone in a weight percentage of 20% of the formulation.
18. The formulation as claimed in claim 8, wherein the formulation is a suspension concentrate (SC) formulation comprising:
(a) Pyroxasulfone in a weight percentage of 10%; Halosulfuron methyl in a weight percentage of 4%; and Mesotrione in a weight percentage of 10% of the formulation;
(b) Pyroxasulfone in a weight percentage of 10%; Halosulfuron methyl in a weight percentage of 4%; and Tembotrione in a weight percentage of 5% of the formulation;
(c) Pyroxasulfone in a weight percentage of 10%; Halosulfuron methyl in a weight percentage of 4%; and Topramezone in a weight percentage of 2% of the formulation;
(d) Pyroxasulfone in a weight percentage of 10%; Halosulfuron methyl in a weight percentage of 4%; and Flumioxazin in a weight percentage of 10% of the formulation; or
(e) Pyroxasulfone in a weight percentage of 16.67%; Halosulfuron methyl in a weight percentage of 6.67%; and Tolpyralate in a weight percentage of 5% of the formulation.

19. The formulation as claimed in claim 8, wherein the formulation is a mixed CS and SC (ZC) formulation comprising Pyroxasulfone in a weight percentage of 4%; Metsulfuron methyl in a weight percentage of 0.133%; and Clomazone in a weight percentage of 20% of the formulation.
20. A process of preparing an herbicidal composition comprising Pyroxasulfone; at least one sulfonylurea herbicide; and at least one additional herbicide; wherein the process comprises the steps of: (a) homogenizing by mixing Pyroxasulfone, sulfonylurea herbicide; and additional herbicide; (b) grinding the mixture of step (a); (c) optionally extruding the ground mixture; and (d) formulating into desired formulation.
21. A method of controlling growth of undesired plants by application of a herbicidally effective amount of an herbicidal composition or formulation comprising Pyroxasulfone; at least one sulfonylurea herbicide; and at least one additional herbicide.
22. A method of preventing undesired plants from infecting crops by applying a herbicidally effective amount of an herbicidal composition or formulation comprising Pyroxasulfone; at least one sulfonylurea herbicide; and at least one additional herbicide.